1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with triazoles in 717 studies
| Studies (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Trials (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Recent Studies (post-2010) (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Studies (triazoles) | Trials (triazoles) | Recent Studies (post-2010) (triazoles) |
|---|---|---|---|---|---|
| 9,156 | 187 | 552 | 25,808 | 2,252 | 13,501 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 56 (7.81) | 18.7374 |
| 1990's | 561 (78.24) | 18.2507 |
| 2000's | 81 (11.30) | 29.6817 |
| 2010's | 18 (2.51) | 24.3611 |
| 2020's | 1 (0.14) | 2.80 |
| Authors | Studies |
|---|---|
| Giessler, C; Mentz, G; Mentz, P; Mest, HJ | 1 |
| Porsius, AJ; Vleeming, W; Wemer, J | 1 |
| Kurachi, Y; McGregor, CG; Mutoh, H; Shimizu, T; Sugimoto, T; Tsuchimochi, H | 1 |
| Black, SC; Driscoll, EM; Lucchesi, BR | 1 |
| Braquet, P; Sagach, VF; Zhukova, AV | 1 |
| Andries, R; Bourgain, RH; Braquet, P; Esanu, A | 1 |
| Bonhomme, B; Braquet, P; Doly, M; Droy-Lefaix, MT; Millerin, M | 1 |
| Ono, S; Voelkel, NF | 2 |
| Esser, KM; Feuerstein, G; Hillegas, LM; Rabinovici, R; Renz, JF; Sofronski, MD; Vernick, J | 1 |
| Hakkert, BC; Hart, MH; Kuijpers, TW; Roos, D | 1 |
| Andrews, MJ; Cunningham, FM; Foster, AP; Lees, P | 2 |
| Böhm, M; Erdmann, E; La Rosée, K; Schwinger, RH | 1 |
| Bates, EJ; Ferrante, A; Kowanko, IC | 1 |
| de Lima, WT; Jancar, S; Sirois, P | 1 |
| Braquet, P; Filep, JG; Földes-Filep, E; Hermán, F; Schneider, F | 1 |
| Turner, NC; Wood, LJ | 1 |
| Auclair, E; Braquet, P; Broquet, C; Chabrier, PE; Domingo, MT; Piro, F | 1 |
| Carolan, EJ; Casale, TB | 2 |
| Bito, H; Honda, Z; Izumi, T; Nakamura, M; Shimizu, T | 1 |
| Donigi-Gale, D; Edwards, R; Norman, KE; Rossi, AG; Shoupe, TS; Williams, TJ | 1 |
| Ambruso, DR; Silliman, CC; Thurman, GW | 1 |
| Rui, YC; Shen, YA; Sun, DX; Zeng, GQ; Zhu, J | 1 |
| Müller, S; Nigam, S | 1 |
| Zhang, JN | 1 |
| Blank, B; Kempe, ER | 1 |
| Bienvenu, K; Granger, DN; Russell, J | 1 |
| Bozza, PT; Castro-Faria-Neto, HC; Cordeiro, RS; Lima, MC; Martins, MA; Silva, AR; Silva, PM; Vargaftig, BB | 1 |
| Asakura, K; Kataura, A; Kojima, T; Narita, S; Saitoh, H; Shirasaki, H | 1 |
| Bahr, T; Grupe, R; Labes, D; Lohde, C | 1 |
| Fisher, RA; Hines, KL | 1 |
| Barrachina, MD; Esplugues, JV; Martinez-Cuesta, MA; Piqué, JM; Whittle, BJ | 1 |
| Iwahisa, Y; Okamoto, H; Terasawa, M | 1 |
| Befus, AD; Davison, JS; Mathison, R | 1 |
| Ono, S; Voelkel, NF; Westcott, JY | 1 |
| Benyó, Z; Csáki, C; Kovách, AG; Szabó, C | 1 |
| Dodam, JR; Johnson, LW; Kruse-Elliott, KT; Olson, NC | 1 |
| Faden, AI; Tzendzalian, PA | 1 |
| Heuer, HO; Muacevic, G | 1 |
| Armstrong, ML; Densen, P; Heistad, DD; Lopez, JA; Mügge, A; Padgett, RC; Piegors, DJ | 1 |
| Levine, BA; McCollum, MO; Olson, MS; Zhou, W | 2 |
| Chao, W; Levine, BA; Olson, MS; Zhou, W | 1 |
| Bewtra, AK; Hopp, RJ; Miyagawa, H; Nabe, M; Okada, C; Townley, G | 1 |
| Shankar, G; Stern, PH | 1 |
| Creutzfeldt, W; Fayyazzi, A; Leonhardt, U; Seidensticker, F; Söling, HD; Stöckmann, F | 1 |
| Caramelo, C; Egido, J; Escanero, J; Gómez-Garre, D; González, E; Guerra, M; López-Farré, A; Riesco, A | 1 |
| Chakrabarty, S; Flores, NA; Fluck, DS; Sheridan, DJ | 1 |
| Chang, SW; Chen, CR; Voelkel, NF | 2 |
| Javors, MA; Olson, MS; Zhou, W | 1 |
| Leong, LL; Papadimitriou, JM; Stephens, CJ; Sturm, MJ; Taylor, RR | 1 |
| Krantz, S; Lefer, AM; Ma, XL; Weyrich, AS | 1 |
| Binnaka, T; Fujimura, K; Inoue, K; Kitagawa, S; Kubota, Y; Mizuno, T; Tani, K; Yamaguchi, T | 1 |
| Bergmann, R; Brecht, HM; Gokel, M; Hammer, C; Saumweber, DM; Zellner, C | 1 |
| Leong, LL; Stephens, CJ; Sturm, MJ; Taylor, RR | 1 |
| Alison, MR; Antoniw, JW; Garvey, B; Maseri, A; Tippins, JR | 1 |
| Bates, EJ; Ferrante, A; Harvey, DP | 1 |
| Blom, M; Koenderman, L; Kok, PT; Roos, D; Tool, AT; Verhoeven, AJ | 1 |
| Chand, N; Diamantis, W; Nolan, K; Sofia, RD | 1 |
| Cardillo, R; DiMuzio, J; Post, TJ; Raible, DG; Schulman, ES | 1 |
| Abraham, WM; Ahmed, T; Mansour, E | 1 |
| Lewis, SA; Raeburn, D; Underwood, SL | 1 |
| Faden, AI; Halt, P | 1 |
| Kawahara, T; Machida, Y; Miyazawa, S; Okano, K; Yamatsu, I | 1 |
| Braillon, A; Cailmail, S; Champigneulle, B; Gaudin, C; Kleber, G; Lebrec, D | 1 |
| Di Braccio, M; Grossi, GC; Leoncini, G; Maresca, M; Roma, G | 1 |
| Amorim, CZ; Cordeiro, RS; Martins, MA; Vargaftig, BB | 1 |
| Ahmed, A; Smith, SK | 1 |
| Braquet, C; Köpernik, W; Mest, HJ; Rein, T; Riedel, A | 1 |
| McIntyre, TM; Prescott, SM; Smiley, PL; Stremler, KE; Zimmerman, GA | 1 |
| Adamus, WS; Birke, FW; Brecht, HM; Heuer, HO; Kempe, ER | 1 |
| Coëffier, E; Joseph, D; Vargaftig, BB | 1 |
| Caplan, MS; Hsueh, W; Kelly, A; Zhang, C | 1 |
| Cavero, I; Floch, A; Sedivy, P; Tahraoui, L | 1 |
| Lim, WH; Stewart, AG | 1 |
| Balsinde, J; Mollinedo, F | 1 |
| Bernat, A; Gigo, V; Herbert, JM; Lale, A; LaPlace, MC; Le Fur, G; Lespy, L; Maffrand, JP; Savi, P; Valette, G | 1 |
| Burghardt, C; Crowley, HJ; Janero, DR; O'Donnell, M; Selig, WM; Welton, AF; Yaremko, B | 1 |
| Corfield, DR; Webber, SE; Widdicombe, JG | 1 |
| Bito, H; Honda, Z; Izumi, T; Matsumoto, T; Minami, M; Mutoh, H; Nakamura, M; Noma, M; Sakanaka, C; Seyama, Y | 1 |
| Durán, WN; Tomeo, AC | 1 |
| Busse, WW; Sedgwick, JB; Vrtis, RR; Zoratti, EM | 1 |
| Gaa, ST; Kohout, TA; Lederer, WJ; Massey, CV; Rogers, TB | 1 |
| Mayeux, PR; Shah, SV; Ueda, N; Walker, PD | 1 |
| Hofmann, B; Kertscher, HP; Lorenz, A; Ostermann, G | 1 |
| Hirafuji, M; Shinoda, H | 3 |
| Goldie, RG; Pedersen, KE; Rigby, PJ | 1 |
| Grigoriadis, G; Stewart, AG | 2 |
| Chan, WP; Levy, JV | 1 |
| Hu, WM; Man, RY | 1 |
| Filep, JG; Fournier, A; Rousseau, A; Sirois, MG; Sirois, P | 1 |
| Harris, T; Stewart, AG | 1 |
| Casals-Stenzel, J | 3 |
| Hara, H; Mase, T; Murase, K; Nagaoka, H; Saito, M; Tomioka, K; Yamada, T | 1 |
| Ammit, AJ; O'Neill, C | 2 |
| Amorim, CZ; Cordeiro, RS; Henriques, MG; Vargaftig, BB; Weg, VB | 1 |
| Brain, SD; Buckley, TL; Collins, PD; Williams, TJ | 1 |
| Cordeiro, RS; Watson, ML; Weg, VB; Williams, TJ | 1 |
| O'Neill, C; Ryan, JP; Spinks, NR | 1 |
| Chand, N; Diamantis, W; Nolan, K; Pillar, J; Sofia, RD | 1 |
| Gilfillan, AM; Hope, WC; Patel, BJ; Welton, AF; Wiggan, GA | 1 |
| Ahmad, Z; Baumann, G; Berdel, WE; Felix, SB; Hashemi, T; Niemczyk, M | 3 |
| Chao, W; Levine, BA; Olson, MS; Zhou, WG | 1 |
| Eliakim, R; Karmeli, F; Okon, E; Rachmilewitz, D | 1 |
| Anderson, BO; Banerjee, A; Bensard, DD; Harken, AH; Nelson, DW; Pitman, JM; Poggetti, RS; Shanley, PF; Whitman, GJ | 1 |
| Honda, Z; Kurokawa, K; Shimizu, T; Takano, T; Uchida, S; Watanabe, T | 1 |
| Ammit, AJ; Fleming, S; Korth, R; O'Neill, C; Wells, X | 1 |
| Beck, T; Bielenberg, GW; Wagener, G | 1 |
| Borst, HG; Fieguth, HG; Haverich, A; Hirt, SW; Jurmann, M; Wahlers, T | 1 |
| Imura, Y; Kawamura, M; Nishikawa, K; Takatani, M; Terashita, Z; Tsushima, S | 1 |
| Catto-Smith, AG; Gall, DG; MacNaughton, WK | 1 |
| Horvath, CJ; Kaplan, JE; Malik, AB | 1 |
| Brandt, R; Kanowski, U; Kempfert, C; Oddoy, A; Siewert, B | 1 |
| Benveniste, J; Bidault, J; Jurgens, P; Leyravaud, S; Ninio, E | 1 |
| Katayama, K; Katayama, S; Sakuma, Y; Shirato, M; Tsunoda, H; Yamatsu, I | 1 |
| Peskar, BA; Pritze, S; Simmet, T | 2 |
| Gall, DG; MacNaughton, WK | 1 |
| Franklin, R; Gelfand, EW; Mazer, BD; Sawami, H | 1 |
| Buckman, D; Iverson, L; Srivastava, A; Thomas, TK; Weis, W; Will, PC; Wilson, C | 1 |
| Bureau, M; Dry, J; Lefort, J; Vargaftig, BB; Vincent, D | 1 |
| Heuer, HO | 4 |
| Klee, A; Schmid-Schönbein, GW; Seiffge, D | 1 |
| Harada, K; Katayama, K; Katayama, S; Muramoto, K; Sakuma, Y; Tsunoda, H | 1 |
| Kulikov, VI; Muzia, GI | 1 |
| Korth, R; Middeke, M | 1 |
| Becker, K; Förster, W; Lueddeckens, G; Rappold, R | 1 |
| Asano, O; Clark, RS; Kawahara, T; Miyamoto, M; Miyazawa, S; Muramoto, K; Okano, K; Sakuma, Y; Shimomura, N; Yoshimura, H | 1 |
| Katayama, K; Katayama, S; Nagaoka, J; Obaishi, H; Ono, H; Sakuma, Y; Shirato, M; Tsunoda, H | 1 |
| Herbert, JM; Lespy, L; Maffrand, JP | 1 |
| Birke, FW; Ensinger, HA | 1 |
| Barnes, PJ; Chung, KF | 1 |
| Braquet, P; Ferreira, MG; Fonteles, MC | 1 |
| Caplan, MS; Hsueh, W; Sun, XM | 2 |
| Darius, H; Heuer, HO; Lohmann, HF; Meyer, J; Schierenberg, M; Treese, N | 1 |
| Braquet, P; Esanu, A; Hosford, D; Laurent, JP; Martin, C; Pommier, J; Rolland, A | 1 |
| Imura, Y; Maezaki, N; Nishikawa, K; Takatani, M; Terashita, Z; Tsushima, S | 1 |
| Bozza, PT; Castro-Faria-Neto, HC; Cordeiro, RS; Correia-Da-Silva, AC; Martins, MA; Morhy, L; Sousa, MV | 1 |
| Baba, I; Hayashi, Y; Katagiri, Y; Suzuki, H; Tanoue, K; Yamazaki, H | 1 |
| Feuerstein, G; Gleason, MM; Gu, JL; Hallenbeck, J; Lysko, PG; Yue, TL | 1 |
| Terasawa, M | 1 |
| Braquet, P; Esanu, A; Hosford, D; Koltai, M; Tosaki, A | 1 |
| Harada, K; Katayama, K; Machida, Y; Obaishi, H; Sakuma, Y; Shimomura, N; Shirato, M; Tsunoda, H; Yamada, K; Yamatsu, I | 1 |
| Calne, RY; Collier, DG; DaCosta, M; Friend, PJ; Luddington, R; Metcalfe, SM; Pollard, SG; Watson, CJ | 1 |
| Heuer, HO; Keller, B; Urich, K | 1 |
| Harvey, W; Hopps, RM; Murphy, CT; Wasil, M | 1 |
| Fenton, J; Gudewicz, PW; Kaplan, JE; Moon, DG; van der Zee, H | 1 |
| Keser, C; Kohl, J; Machleidt, W; Schweiberer, L; Siebeck, M; Spannagl, M; Weipert, J | 1 |
| Balmes, J; Fine, J; Gordon, T; Sheppard, D | 1 |
| Bradley, LM; Czaja, JF; Goldstein, RE; Stambouly, JJ | 1 |
| Gundel, RH; Letts, LG; Wegner, CD | 1 |
| Burrows, LJ; Lindley, ID; Piper, PJ; Westwick, J | 1 |
| Ban, C; Hasegawa, M; Ihara, Y; Inamori, K; Itoh, H; Li, XM; Mori, T; Okagaki, A; Sagawa, N | 1 |
| Abendschein, DR; Bergmann, SR; Haskel, EJ; Torr, SR; VonVoigtlander, PF | 1 |
| Bonne, C; Meynier, F; Muller, A | 1 |
| Goldie, RG; Paterson, JW; Pedersen, KE; Rigby, PJ | 1 |
| Mikashima, H; Muramoto, Y; Setoguchi, M; Tahara, T; Takehara, S; Terasawa, M | 1 |
| Giers, G; Janzarik, H; Kempe, ER; Mueller-Eckhardt, C | 2 |
| Bazan, NG; Braquet, PG; Emoto, SE; Esanu, A; Fitzpatrick, JH; Gilboe, DD; Kintner, D | 1 |
| Dive, C; Watson, JV; Workman, P | 1 |
| Donaldson, J; Lohmeyer, M; Workman, P | 1 |
| Bergmann, R; Brecht, HM; Gokel, M; Hammer, C; Saumweber, DM | 1 |
| Abbas, MK; Casale, TB | 1 |
| Crowley, H; Flynn, T; Maresca, C; Mason, C; O'Donnell, M; Walser, A; Yaremko, B | 1 |
| Heuer, H; Meade, CJ | 1 |
| Neugarten, J; Schlondorff, D; Yoo, J | 1 |
| Crowley, H; Flynn, T; Maresca, C; Mason, C; O'Donnell, M; Walser, A | 1 |
| Horie, M; Mase, T; Nagaoka, H; Sakurai, Y; Tomioka, K; Yamada, T | 1 |
| Hirasawa, N; Mue, S; Ohuchi, K; Omata, M; Tsurufuji, S; Watanabe, M; Yagi, M | 1 |
| Barnes, PJ; Chung, KF; Lötvall, JO; Tokuyama, K | 1 |
| Feuerstein, G; Gleason, MM; Hallenbeck, J; Yue, TL | 1 |
| Braquet, P; Friedrich, G; Giessler, J; Hirschelmann, R; Madi, S | 1 |
| Braquet, P; Esanu, A | 1 |
| Arima, M; Makino, S; Sagara, H; Terashi, Y; Yukawa, T | 1 |
| Barnes, PJ; Challiss, RA; Chilvers, ER; Giembycz, MA; Kroegel, C | 1 |
| Barnes, PJ; Chung, KF; Griffith, S; Hayes, JP; Ridge, SM | 1 |
| Barnes, PJ; Belvisi, MG; Stretton, CD | 1 |
| Barnes, PJ; Dijk, S; Rogers, DF | 1 |
| Clark, R; Harada, K; Horie, T; Katayama, S; Miyazawa, S; Muramoto, K; Okano, K; Sakuma, Y; Shimomura, N; Tsunoda, H | 2 |
| Harada, K; Katayama, S; Machida, Y; Miyazawa, S; Obaishi, H; Okano, K; Sakuma, Y; Shirato, M; Tsunoda, H; Yamada, K | 1 |
| Cordeiro, RS; e Silva, PM; Martins, MA; Pasquale, CP; Vargaftig, BB | 1 |
| Aratani, H; Setoguchi, M; Tahara, T; Terasawa, M | 1 |
| Evans, RW; Kochanek, PM; Magargee, MJ; Melick, JA; Nemoto, EM; Schoettle, RJ | 2 |
| Egan, RW; Fernandez, X; Gulbenkian, AR; Kreutner, W; Kung, T; Minnicozzi, M; Watnick, AS | 1 |
| Heuer, HO; Letts, G; Meade, CJ | 1 |
| Hauser, A; Heinroth-Hoffmann, I; Mest, HJ | 1 |
| Geissler, FT; Henderson, WR; Kuzan, FB | 1 |
| Aepfelbacher, M; Korth, R; Weber, PC | 1 |
| Barnes, PJ; Giembycz, MA; Kroegel, C | 1 |
| Barnes, PJ; Chanez, P; Dent, G; Sybrecht, GW; Ukena, D | 1 |
| Granger, DN; Ibbotson, G; Kubes, P; Russell, J; Wallace, JL | 1 |
| Bloom, JW; Gomez, J; Halonen, M; Yamamura, HI | 1 |
| Zhang, F | 1 |
| Blair, IA; Christman, BW; Lefferts, PL; Snapper, JR | 1 |
| Beckerman, RC; Bellan, JA; Braquet, P; Dyson, MC; Kadowitz, PJ; McNamara, DB; Minkes, RK; Wegmann, MJ | 1 |
| Collins, PD; Tannière-Zeller, M; Williams, FM; Williams, TJ | 1 |
| Esser, KM; Farhat, M; Feuerstein, G; Rabinovici, R; Slivjak, M; Smith, EF; Yue, TL | 1 |
| Feuerstein, G; Frerichs, KU; Hallenbeck, JM; Lindsberg, PJ; Yue, TL | 1 |
| Conklyn, M; Conyers, G; Cramer, E; Milks, L; Showell, H | 1 |
| Casals-Stenzel, J; Heuer, HO | 1 |
| Brendel, W; Conzen, PF; Gutmann, R; Habazettl, H; Hobbhahn, J; Peter, K; Vollmar, B; Yekebas, E | 1 |
| Conklyn, M; Showell, HJ; Watson, JW | 1 |
| Durham, SK; Selig, WM; Tocker, JE; Welton, AF | 1 |
| Barnes, PJ; Evans, TW; McCormack, DG | 2 |
| Bazill, GW; Dexter, TM | 1 |
| Jones, SB; Qi, M | 1 |
| Charlier, A; Keyeux, A; Pouleur, H; Raigoso, J; Schröder, E; Van Mechelen, H | 1 |
| Barton, PA; Mandel, DM; Matrosic, K; Warren, JS | 1 |
| Casals-Stenzel, J; Heuer, HO; Muacevic, G; Weber, KH | 1 |
| Befus, AD; Davison, JS; Mathison, R; Rimmer, C; Wallace, JL | 1 |
| Gerring, EL; King, JN | 1 |
| Conroy, DM; Piper, PJ; Samhoun, MN | 1 |
| Chang, SW; Fernyak, S; Voelkel, NF | 1 |
| Armour, CL; Black, JL; Johnson, PR | 1 |
| Finn, CA; Milligan, SR | 1 |
| Barnes, PJ; Chung, KF; Cole, PJ; Kroegel, C; Read, RC; Rutman, A; Wilson, R; Yukawa, T | 1 |
| Fenton, JW; Kaplan, JE; Krasodomski, JA; Moon, DG; Morton, KD; van der Zee, H | 1 |
| Handley, DA; Havill, AM; Van Valen, RG | 1 |
| Adamus, WS; Heuer, HO; Meade, CJ; Schilling, JC | 1 |
| Cordeiro, RS; Fernandes, PD; Henriques, MG; Martins, MA; Silva, PM; Vargaftig, BB; Weg, VB | 1 |
| Håkansson, L; Venge, P | 1 |
| Burton, DL; Cotter, JL; Sturm, MJ; Vandongen, R | 1 |
| Farhat, M; Feuerstein, G; Rabinovici, R; Yue, TL | 1 |
| Bassot, S; Chignard, M; Ferrer-Lopez, P; Laurent, P; Renesto, P; Schattner, M | 1 |
| Adi, S; Feingold, KR; Fiers, W; Grunfeld, C; Moser, A; Soued, M | 1 |
| Feuerstein, GZ; Frerichs, KU; Hallenbeck, JM; Lindsberg, PJ | 1 |
| Erjefält, I; O'Donnell, SR; Persson, CG | 1 |
| Hogaboam, CM; McKnight, GW; Wallace, JL | 1 |
| Desquand, S; Dumarey, C; Lefort, J; Vargaftig, BB | 1 |
| Halonen, M; Lohman, I | 1 |
| Calne, RY; Da Costa, M; Metcalfe, S | 1 |
| Bergmann, R; Brecht, HM; Hammer, C; Saumweber, DM | 1 |
| Farhat, M; Feuerstein, G; Perera, PY; Rabinovici, R; Vogel, SN; Yue, TL | 1 |
| Feuerstein, G; Rabinovici, R; Rudolph, AS; Yue, TL | 1 |
| Lefort, J; Pretolani, M; Vargaftig, BB | 1 |
| Dubbin, PN; Dusting, GJ; Harris, T; Stewart, AG | 1 |
| Piper, PJ; Yaacob, HB | 1 |
| Barnes, P; Chanez, P; Dent, G; Sybrecht, G; Ukena, D | 1 |
| Heuer, H; Weber, KH | 1 |
| Griffin, K; Hong, T; Levy, JV | 1 |
| Barnes, PJ; Chung, KF; Dent, G; Kroegel, C; Venge, P; Yukawa, T | 1 |
| Barnes, PJ; Dent, G; Krogel, C; Sybrecht, G; Ukena, D; Yukawa, T | 1 |
| Braquet, P; Cluzel, J; Doly, M; Meyniel, G; Thierry, A | 1 |
| Barnes, PJ; Kroegel, C; Westwick, J; Yukawa, T | 1 |
| Phillips, WA; Stewart, AG | 1 |
| Barnes, PJ; Dent, G; Sybrecht, GW; Ukena, D | 1 |
| Benveniste, J; Bidault, J; Delautier, D; Hirafuji, M; Keraly, CL; Korth, R | 1 |
| Bralet, J; Rochette, L; Tannière-Zeller, M | 1 |
| Bienenstock, J; Hanglow, AC; Perdue, MH | 1 |
| Koenderman, L; Roos, D; Tool, AT; Verhoeven, AJ | 1 |
| Braquet, P; Domingo, MT; Etienne, A; Martins, MA; Soulard, C | 1 |
| Casals-Stenzel, J; Heuer, H | 2 |
| Imura, Y; Iwasaki, K; Nishikawa, K; Shibouta, Y; Terashita, Z | 1 |
| Bitterman, H; Lefer, AM; Stahl, GL | 1 |
| Abraham, WM; Garrido, R; Stevenson, JS | 1 |
| Adamus, WS; Heuer, H; Meade, CJ | 1 |
| Petty, AC; Scrutton, MC | 1 |
| Benveniste, J; Brink, C; Brunelleschi, S; Fantozzi, R; Giotti, A; Ledda, F; Renzi, D | 1 |
| Antoniw, JW; Izumi, T; Piper, PJ; Stanton, AW | 1 |
| Dixon, EJ; Page, CP; Robertson, DN; Wilsoncroft, P | 1 |
| Abraham, WM; Sielczak, MW; Solèr, M | 1 |
| Heuer, H | 1 |
| Bahrami, S; Paul, E; Redl, H; Schiesser, A; Schlag, G; Thurnher, M; Vogl, C | 1 |
| Fauler, J; Frölich, JC; Sielhorst, G | 1 |
| Hoffmann, IH; Mentz, G; Mentz, P; Mest, HJ; Meyer, E; Riedel, A; Sperling, J; Tschorn, W | 1 |
| Chang, SW; Kuo, G; Ohara, N; Voelkel, NF | 1 |
| Barnes, PJ; Chung, KF; Evans, P; Fukuda, T; Kroegel, C; Yukawa, T | 1 |
| Dusting, GJ; Stewart, AG | 1 |
| Adamus, WS; Lohmann, HF; Meade, CJ | 1 |
| Adamus, WS; Brecht, HM; Heuer, H; Meade, CJ | 1 |
| Barnes, PJ; Chung, KF; Kroegel, C; Pleass, R; Westwick, J; Yukawa, T | 1 |
| Bozza, PT; Cordeiro, RS; Dias, PM; Faria Neto, HC; Lima, MC; Martins, MA; Silva, PM; Vargaftig, BB | 1 |
| Del Monte, M; Subissi, A | 1 |
| Fortes, ZB; Garcia-Leme, J; Lagente, V; Vargaftig, BB | 2 |
| Adamus, WS; Brecht, HM; Frey, G; Heuer, H; Meade, CJ | 1 |
| Griffin, KJ; Levy, JV | 1 |
| Barnes, PJ; Birke, FW; Dent, G; Robaut, C; Sybrecht, GW; Ukena, D | 1 |
| Aursudkij, B; Barnes, PJ; Chung, KF; Dent, G; Evans, TW; Rogers, DF | 1 |
| Barnes, PJ; Chanez, P; Chung, KF; Dent, G; Kroegel, C; Yukawa, T | 1 |
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| Bruyneel, E; Chastre, E; Gespach, C; Kotelevets, L; Mareel, M; Myssiakine, E; Noë, V | 1 |
| Shirasawa, E; Tsuji, F | 1 |
| Inoue, S; Kume, K; Ota, Y; Sato, S; Shimada, A; Shimizu, T; Sugiyama, Y | 1 |
| Akagawa, Y; Dohi, T; Imai, Y; Itadani, K; Kitayama, S; Morita, K; Yamaki, H | 1 |
| Coghe, J; da Silva, MB; David, JL; Dessy, C; Lekeux, P | 1 |
| Bazan, NG; Davis, RJ; DeCoster, MA; Mukherjee, PK | 1 |
| Bast, A; Buurman, WA; Kramer, K; Pennings, HJ; Wouters, EF | 1 |
| Chermat-Izard, V; Hilliquin, P; Menkes, CJ | 1 |
| Beyer, AJ; Cheung, LY; Shyr, YM; Smalley, DM; Wood, JG | 1 |
| Aizawa, H; Hara, N; Inoue, H; Koto, H; Matsumoto, K; Nakano, H; Shigyo, M; Takata, S | 1 |
| Hibler, S; Ibe, BO; Raj, JU | 1 |
| Knol, EF; Liu, L; Lutter, R; Mul, FP; Roos, D; Verhoeven, AJ; Zuurbier, AE | 1 |
| Cakici, I; Kanzik, I; Sariahmetoğlu, M | 1 |
| Chai, OH; Choi, IH; Ha, TY; Han, EH; Im, SY; Lee, HK; Lee, MS; Park, JS; Shin, YM | 1 |
| Jancar, S; Steil, AA; Tavares de Lima, W | 1 |
| Diefenbeck, M; Hammer, C; Linke, R; Seehofer, D | 1 |
| Kagoshima, M; Komatsu, H; Okumoto, T; Tomomatsu, N; Yamaguchi, S | 2 |
| Biancone, L; Bussolati, B; Cambi, V; Camussi, G; David, S; Foà, R; Mariano, F | 1 |
| Bazan, NG; Campbell, FZ; Davis, RJ; DeCoster, MA; Mukherjee, PK | 1 |
| Alexander, JS; Coe, L; Itoh, M; Okayama, N; Oshima, T | 1 |
| Baethmann, A; Pickelmann, S; Schürer, L; Uhl, E | 1 |
| Baethmann, A; Pickelmann, S; Röhrich, F; Schürer, L; Uhl, E | 1 |
| Battaglia, E; Brizzi, MF; Camussi, G; Del Sorbo, L; Dentelli, P; Garbarino, G; Montrucchio, G; Pegoraro, L | 1 |
| Chung, PS; Jeong, PS; Jung, TT; Kim, YH; Rhee, CK | 1 |
| Biancone, L; Bussolati, B; Camussi, G; Conaldi, PG; Del Sorbo, L; DeMartino, A; Toniolo, A | 1 |
| Backer, CL; Crawford, SE; Gonzalez-Crussi, F; Hsueh, W; Huang, L; Liu, H; Mavroudis, C; Mu, Y; Takami, H | 1 |
| Kulikov, VI; Muzya, GI | 1 |
| Bocheński, J; Chłopicki, S; Gryglewski, RJ | 1 |
| Barreiro, EJ; de Alencastro, RB; Fraga, CA; Rodrigues, CR | 1 |
| Dewhurst, S; Gelbard, HA; Maggirwar, SB; Ramirez, S; Tong, N | 1 |
| Aimbire, F; Cailleaux, S; Cordeiro, RS; Lopes-Martins, RA; Tibiriçá, E | 1 |
| Alloatti, G; Camussi, G; De Martino, A; Montrucchio, G; Penna, C | 1 |
| Brizzi, MF; Camussi, G; Del Sorbo, L; Dentelli, P; Garbarino, G; Molinar, A; Pegoraro, L; Rosso, A | 1 |
| Berliner, JA; Faull, KF; Leitinger, N; Shih, PT; Subbanagounder, G | 1 |
| Baker, KE; Curtis, MJ | 2 |
| Eura, M; Fukui, H; Ishikawa, T; Masuyama, K; Nakasaki, T; Ogino, S; Samejima, Y; Yumoto, E | 1 |
| Fonteles, MC; Lima, AA; Monteiro, HS | 1 |
| Bazan, NG; DeCoster, MA; Serou, MJ | 1 |
| Flickinger, BD; Mustafa, SB; Olson, MS | 1 |
| Albini, A; Biancone, L; Boccellino, M; Bussolati, B; Camussi, G; Cantaluppi, V; Conaldi, PG; Del Sorbo, L; Toniolo, A | 1 |
| Gebhart, GF; Ozaki, N; Sengupta, JN | 1 |
| Chłopicki, S; Olszanecki, R | 1 |
| Quinn, JV; Slotman, GJ | 1 |
| Akiyama, Y; Iwane, S; Komatsu, H; Mizuki, M; Tsuda, T | 1 |
| Barros, FS; Dutra, PM; Lopes, AH; Meyer-Fernandes, JR; Rodrigues, CO; Souto-Padrón, T | 1 |
| Battaglia, E; Biancone, L; Boccellino, M; Camussi, G; Del Sorbo, L; Emanuelli, G; Lupia, E; Montrucchio, G | 1 |
| Atuma, C; Engstrand, L; Holm, L | 1 |
| Bulkley, GB; Fuh, KC; Klein, AS; Maemura, K; Meneshian, A; Owaki, T; Takao, S; Wang, D | 1 |
| Chang, H; De Plaen, IG; Hsueh, W; Remick, DG; Tan, XD; Wang, L | 1 |
| Evanson, OA; Fagliari, JJ; McClenahan, DJ; Weiss, DJ | 1 |
| Berthou, C; Bourge, JF; Denizot, Y; Geromin, D; Sasportes, M; Sigaux, F; Soulié, A; Zhang, Y | 1 |
| Caplan, M; Chang, H; Gonzalez-Crussi, F; Hsueh, W; Qu, XW; Tan, XD | 1 |
| Howard, KM; Olson, MS | 1 |
| Ibe, BO; Raj, JU; Sander, FC | 1 |
| Boichot, E; Braquet, P; Carre, C; Guinot, P; Lagente, V; Mencia-Huerta, JM | 1 |
| Ahmed, A; Ahmed, Z; Dearn, S; Eggo, MC; Lewis, A; Rahman, M | 1 |
| Palmer, C; Roberts, RL; Viswanath, M | 1 |
| Komatsu, H; Kusuhara, H; Matsuyuki, H; Sugahara, K; Terasawa, M; Yamaguchi, S | 1 |
| Cho, HG; Cho, O; Hybertson, BM; Lee, YM; Repine, AJ; Repine, JE; Terada, LS | 1 |
| Sun, GY; Wang, JH | 1 |
| Choi, IW; Choi, JH; Chung, WJ; Han, SJ; Han, SS; IM, SY; Jang, KY; Lee, DG; Lee, HB; Lee, HK; Park, KH | 1 |
| Aksungar, FB; Bilsel, S; Bozkurt, A; Cetinel, U; Coşkun, T; Granger, DN; Haklar, G; Kurtel, H; Oktar, BK; Yegen, BC; Yüksel, M | 1 |
| Barreiro, EJ; de Miranda, AL; Fraga, AG; Fraga, CA; Rodrigues, CR | 1 |
| Dohi, T; Kitayama, S; Kurihara, H; Mizuno, N; Morita, K; Shibata, K; Shinohara, H; Yoshino, H | 1 |
| Biancone, L; Bussolati, B; Camussi, G; Cassoni, P; Montrucchio, G; Rola-Pleszczynski, M; Russo, S | 1 |
| Alloatti, G; Camussi, G; Mariano, F; Penna, C | 1 |
| Aizawa, H; Fukuyama, S; Hara, N; Inoue, H; Komori, M; Koto, H; Matsumoto, K | 1 |
| Arese, M; Biancone, L; Bussolino, F; Camussi, G; Del Sorbo, L; Giraudo, E; Tizzani, M | 1 |
| Balogh, I; Kecskeméti, V | 1 |
| Fujimura, A; Kawaguchi, A; Sugimoto, K | 1 |
| Ida, S; Ishizuka, S; Kamanaka, M; Nakayama, K; Sasaki, H; Sekizawa, K; Suzuki, T; Yamaya, M | 1 |
| Li, J; Tu, W; Zhu, W | 1 |
| Dutra, PM; Lopes, AH; Pereira, AF; Rosa , MS; Vieira, RB | 1 |
| Barks, JD; Eun, BL; Liu, XH | 1 |
| Chang, PY; Chen, CH; Henry, PD; Jiang, T; Lee, YT; Lu, SC; Luo, S | 1 |
| Chen, Y; Huang, H; Liu, Y | 1 |
| Fonteles, MC; Havt, A; Monteiro, HS | 1 |
| Li, J; Li, N; Tu, W; Zhu, W | 1 |
| Ichinowatari, G; Ohuchi, K; Tanimoto, A; Tsuyuki, K; Yaginuma, H; Yamada, M | 2 |
| Makiyama, Y; Mitsui, Y; Tanaka, Y | 1 |
| Evanson, OA; McClenahan, DJ; Weiss, DJ | 1 |
| Bianchi, L; Cellai, C; Della Malva, N; Laurenzana, A; Paoletti, F; Vannucchi, AM | 1 |
| Carlson, SL; Hostettler, ME | 1 |
| Carlson, SL; Hostettler, ME; Knapp, PE | 1 |
| Benito, E; Bosch, MA | 1 |
| Evanson, OA; Weiss, DJ | 1 |
| Gokorsch, S; Grimminger, F; Krüll, M; Lohmeyer, J; Mayer, K; Merfels, M; Muhly-Reinholz, M; Rosseau, S; Schwarzer, N; Seeger, W; Suttorp, N | 1 |
| Greischel, A; Leusch, A; Müller, G; Roth, W; Sauer, A; Volz, A; Wagner, A | 1 |
| Boyle, HL; Jauchem, JR; Ryan, KL; Tehrany, MR | 1 |
| Choi, EK; Choi, IW; Choi, JH; Han, SJ; Im, SY; Ko, HM; Lee, HK; Lee, HS; Seo, KH | 1 |
| Magnusson, JE; Teather, LA; Wurtman, RJ | 1 |
| Grandel, U; Grimminger, F; Hattar, K; Hoffmann, S; Mayer, K; Schenkel, A; Seeger, W; Sibelius, U | 1 |
| Cheung, LY; Childs, EW; Hunter, FA; Smalley, DM; Udobi, KF; Wood, JG | 1 |
| Cho, HG; Hybertson, BM; Lee, YM; Repine, JE | 1 |
| Rasheed, H; Saeed, SA | 1 |
| Dow, CS; Falcioni, G; Gabbianelli, R; Swoboda, B; Vince, FP | 1 |
| Biffl, WL; Carnaggio, R; Gonzalez, RJ; Moore, EE; Offner, PJ; Silliman, CC; West, KE | 1 |
| Casillan, AJ; Gonzalez, NC; Johnson, JS; Steiner, DR; Wood, JG | 1 |
| Kato, M; Kurose, T; Miyaji, S; Oda, T | 1 |
| Bussolati, B; Camussi, G; Deambrosis, I; Mariano, F; Russo, S | 1 |
| Alloatti, G; Altruda, F; Azzolino, O; Barberis, L; Bedendi, I; Bosco, O; Del Sorbo, L; Hirsch, E; Levi, R; Malan, D; Marcantoni, A; Montrucchio, G; Penna, C; Wymann, M | 1 |
| Rhee, CK | 1 |
| Jung, TT; Park, SK; Rhee, CK | 1 |
| Al-Salti, W; Booth, IW; Coney, AM; Ewer, AK; Marshall, JM; Ramani, P | 1 |
| John, EO; Jung, TT; Park, SK; Park, YS; Rhee, CK | 1 |
| Burgos, RA; Folch, H; Hancke, JL; Hermosilla, R; Hidalgo, MA; Matthei, SM | 1 |
| Chlopicki, S; Jakubowski, A; Olszanecki, R | 1 |
| Imoto, K; Kato, M; Miyaji, S; Miyake, H; Nakamura, M; Oda, T | 1 |
| Bazan, HE; Bazan, NG; Ma, X; Ottino, P | 1 |
| Alloatti, G; Berta, G; Cappello, S; Gattullo, D; Losano, G; Mognetti, B; Pagliaro, P; Penna, C | 1 |
| Hagiwara, K; Kanazawa, M; Kikuchi, I; Kikuchi, S; Kobayashi, T; Nagata, M; Sakamoto, Y | 1 |
| Caporale, R; Cellai, C; Di Lollo, S; Laurenzana, A; Paglierani, M; Pancrazzi, A; Paoletti, F; Vannucchi, AM | 1 |
| De Plaen, IG; Ghosh, S; Han, XB; Hsueh, W; Liu, X; May, MJ | 1 |
| Azambuja, P; Garcia, ES; Machado, EM | 1 |
| Calixto, JB; Kassuya, CA; Marotta, DM; Menezes-de-Lima, O; Rehder, VL; Silvestre, A | 1 |
| Calorini, L; Fallani, A; Gabellieri, S; Mannini, A; Mugnai, G; Ruggieri, S | 1 |
| Jancar, S; Machado, MC; Molan, NA; Shio, MT; Souza, LJ | 1 |
| Peng, K; Tang, YL; Wang, S; Xu, ZX; Yang, YZ | 1 |
| Chen, Z; Dupré, DJ; Larrivée, JF; Le Gouill, C; Rola-Pleszczynski, M; Rollin, S; Stanková, J; Thompson, C | 1 |
| Fukuda, J; Furukawa, Y; Kawano, Y; Matsumoto, H; Narahara, H; Yuge, A | 1 |
| Azambuja, P; Figueiredo, MB; Garcia, ES | 1 |
| Bailey, SR; Cunningham, FM; Elliott, J; Menzies-Gow, NJ; Sepulveda, MF | 1 |
| Abdallah, MF; Ibe, BO; Portugal, AM; Raj, JU | 1 |
| Bloechle, C; Izbicki, JR; Kaifi, J; Kluth, D; Mann, O; Schneider, C; Strate, T; Tiefenbacher, WJ; Yekebas, E | 1 |
| Anderson, R; Steel, HC; Tintinger, GR | 1 |
| Calixto, JB; Campos, MM; Costa, R; Fernandes, ES; Marotta, DM; Medeiros, R; Motta, EM; Quintão, NL | 1 |
| Anderson, R; Steel, HC; Theron, AJ; Tintinger, GR | 1 |
| Borgeat, P; Flamand, N; Lefebvre, JS; Lévesque, T; Marleau, S; Milot, V; Picard, S | 1 |
| Davoine, F; Druey, KM; Dyer, KD; Kim, JD; Lacy, P; Moqbel, R; Percopo, CM; Rosenberg, HF; Xie, Z; Yang, Z | 1 |
| Barbiéri, CL; de Souza Carmo, EV; Katz, S | 1 |
| Asaka, N; Kakuo, H; Kiniwa, M; Ohmori, K; Oka, T; Sasaki, E; Togawa, M; Yamada, S | 1 |
| Alviano, CS; Alviano, DS; Atella, GC; Folly, E; Gomes, MT; Lopes, AH; Silva-Filho, FC; Zimmermann, LT | 1 |
| Faez, S; Frimmel, SA; Garland, RC; Hafezi-Moghadam, A; Nakao, S; Schering, A; Sun, D; Tayyari, F; Xie, F; Zandi, S | 1 |
| Abdel-Al, M; Ditmyer, M; Howard, KM; Patel, N | 1 |
| Ajiro, Y; Giles, WR; Saegusa, N; Spitzer, KW; Stafforini, DM | 1 |
| Arteaga, A; Bae, R; Ibe, BO; Raj, JU | 1 |
| Demopoulos, CA; Papakyriakou, A; Philippopoulos, AI; Tsoupras, AB | 1 |
| Andréasson, E; Bylund, J; Christenson, K; Dahlgren, C; Forsman, H; Karlsson, A; Önnheim, K | 1 |
| Bessi, VL; Bitencourt, CS; Borgeat, P; Faccioli, LH; Hamdan, L; Huynh, DN; Lefebvre, JS; Lévesque, T; Marleau, S; Ménard, L; Sohouhenou, F | 1 |
| Albano, RM; Carvalho, S; da Conceição Costa, J; de Carvalho, L; de Oliveira Lima Santos, SA; Mallet de Lima, CD; Plotkowski, MC; Saliba, AM; Teixeira, MM | 1 |
| Almeida, IC; Gazos-Lopes, F; Gomes, MT; Hoelz, LV; Lopes, AH; Marques, AF; Monteiro, RQ; Nakayasu, ES; Oliveira, MM; Pascutti, PG; Salloum, NG; Souto-Padrón, T; Vieira, DP | 1 |
| Sahu, RP | 1 |
| Goto, S; Itoh, H; Nagai, M; Ohmori, K; Osada, H; Sasaki, K; Shimizu, S; Shimoda, M; Shirai, J; Watanabe, M | 1 |
| Abhilasha, KV; Chaithra, VH; Chen, CH; Jacob, SP; Kemparaju, K; Lakshmikanth, CL; Marathe, GK; McIntyre, TM; Sahu, RP; Sumanth, MS; Thyagarajan, A; Travers, JB | 1 |
| Cong, Q; Gao, T; Jiang, W; Sun, M; Wang, Y; Xu, C; Yao, L; Yu, Y | 1 |
| Liu, L; Liu, ZL; Zhang, F; Zhang, H | 1 |
14 review(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and triazoles
| Article | Year |
|---|---|
Platelet-activating factor receptor and signal transduction.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Azepines; Cloning, Molecular; GTP-Binding Proteins; Humans; Molecular Sequence Data; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Second Messenger Systems; Sequence Homology, Amino Acid; Signal Transduction; Triazoles | 1992 |
Thieno-triazolo-1,4-diazepines as antagonists of platelet-activating factor: present status.
Topics: Animals; Azepines; Central Nervous System; Flumazenil; Humans; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazolam; Triazoles | 1991 |
The effects of hetrazepine PAF antagonists in preclinical models of asthma.
Topics: Anaphylaxis; Animals; Antigens; Asthma; Azepines; Blood Platelets; Bronchi; Bronchoconstriction; Capillary Permeability; Cell Movement; Eosinophils; Lung; Platelet Activating Factor; Respiratory Hypersensitivity; Triazoles | 1991 |
[Phospholipid thrombocyte activating factor, its analogs and antagonists: prospects of their use in medicine].
Topics: Azepines; Diterpenes; Fibrinolytic Agents; Ginkgolides; Humans; In Vitro Techniques; Lactones; Lysophosphatidylcholines; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Thrombosis; Triazoles | 1991 |
Role for platelet-activating factor in asthma.
Topics: Animals; Asthma; Azepines; Eosinophils; Humans; Muscle, Smooth; Platelet Activating Factor; Respiratory Physiological Phenomena; Respiratory System; Triazoles | 1991 |
Hypoxia, PAF, and necrotizing enterocolitis.
Topics: Animals; Azepines; Enterocolitis; Humans; Hypoxia; Intestines; Necrosis; Platelet Activating Factor; Quinolinium Compounds; Triazoles | 1991 |
Involvement of platelet-activating factor (PAF) in septic shock and priming as indicated by the effect of hetrazepinoic PAF antagonists.
Topics: Animals; Azepines; Endotoxins; Humans; Models, Biological; Multiple Organ Failure; Platelet Activating Factor; Shock, Septic; Triazoles | 1991 |
From ginkgolides to N-substituted piperidino-thieno diazepines, a new series of highly potent dual antagonists.
Topics: Animals; Azepines; Diterpenes; Ginkgolides; Humans; Lactones; Piperidines; Plant Extracts; Platelet Activating Factor; Tetrazoles; Thienopyridines; Triazoles | 1991 |
PAF antagonism as an approach to the treatment of airway hyperreactivity.
Topics: Allergens; Animals; Asthma; Azepines; Bronchoconstriction; Diterpenes; Ginkgolides; Humans; Lactones; Platelet Activating Factor; Triazoles | 1991 |
New trends in PAF antagonist research: a new series of potent hetrapazine-derived PAF antagonists.
Topics: Animals; Azepines; Platelet Activating Factor; Tetrazoles; Thienopyridines; Triazoles | 1991 |
Clinical experience with platelet-activating factor antagonists. Past, present, and near future.
Topics: Animals; Azepines; Clinical Trials as Topic; Graft Rejection; Humans; Kidney Transplantation; Lactones; Plant Extracts; Platelet Activating Factor; Randomized Controlled Trials as Topic; Shock, Septic; Thienopyridines; Triazoles | 1994 |
PAF-cytokine autocatalytic feed-back network in septic shock: involvement in acute renal failure.
Topics: Acute Kidney Injury; Animals; Azepines; Cytokines; Diterpenes; Down-Regulation; Feedback; Ginkgolides; Humans; Lactones; Lipopolysaccharides; Platelet Activating Factor; Shock, Septic; Triazoles | 1994 |
Activation of the phospholipase/cyclooxygenase cascade in the rabbit cornea by platelet-activating factor is challenged by PAF receptor antagonists.
Topics: Animals; Arachidonic Acid; Azepines; Cornea; Enzyme Activation; Phospholipases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prostaglandin-Endoperoxide Synthases; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles | 1995 |
[PAF receptor antagonist in asthma therapy].
Topics: Animals; Asthma; Azepines; Humans; Platelet Activating Factor; Triazoles | 1996 |
10 trial(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and triazoles
| Article | Year |
|---|---|
Pharmacodynamics, pharmacokinetics and safety profile of the new platelet-activating factor antagonist apafant in man.
Topics: Adult; Azepines; Blood Cell Count; Blood Chemical Analysis; Blood Platelets; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Intestinal Absorption; Male; Middle Aged; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Binding; Random Allocation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1991 |
Inhibition of cutaneous and platelet responses to platelet-activating factor by oral WEB 2086 in man.
Topics: Administration, Oral; Adult; Azepines; Dose-Response Relationship, Drug; Double-Blind Method; Histamine; Humans; Injections, Intradermal; Male; Placebos; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Skin; Skin Tests; Triazoles | 1991 |
Inhibitory effects of the new PAF acether antagonist WEB-2086 on pharmacologic changes induced by PAF inhalation in human beings.
Topics: Administration, Inhalation; Administration, Oral; Adult; Airway Resistance; Azepines; Bronchi; Bronchial Provocation Tests; Double-Blind Method; Hemodynamics; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Reproducibility of Results; Triazines; Triazoles | 1990 |
Safety, tolerability, and pharmacologic activity of multiple doses of the new platelet activating factor antagonist WEB 2086 in human subjects.
Topics: Adult; Azepines; Blood Pressure; Double-Blind Method; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Pulse; Random Allocation; Respiration; Time Factors; Triazines; Triazoles | 1989 |
Effects of a PAF antagonist, Y-24180, on bronchial hyperresponsiveness in patients with asthma.
Topics: Adult; Analysis of Variance; Asthma; Azepines; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles | 1995 |
Quantitative measurement of BN50727 in human plasma and urine by combined liquid chromatography/negative ion chemical ionization mass spectrometry using a particle beam interface.
Topics: Adult; Azepines; Chromatography, High Pressure Liquid; Humans; Male; Mass Spectrometry; Platelet Activating Factor; Thienopyridines; Triazoles | 1994 |
The effect of the orally active platelet-activating factor antagonist WEB 2086 in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adult; Aged; Albuterol; Asthma; Azepines; Beclomethasone; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Peak Expiratory Flow Rate; Platelet Activating Factor; Triazoles | 1994 |
Effect of a platelet activating factor antagonist, WEB 2086, on allergen induced asthmatic responses.
Topics: Administration, Oral; Adult; Asthma; Azepines; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Platelet Activating Factor; Respiratory Hypersensitivity; Time Factors; Triazoles | 1993 |
Effect of a potent platelet-activating factor antagonist, WEB-2086, on asthma. A multicenter, double-blind placebo-controlled study in Japan.
Topics: Adolescent; Adult; Aged; Anti-Asthmatic Agents; Asthma; Azepines; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Activating Factor; Treatment Outcome; Triazoles | 1996 |
A double blind, placebo controlled study of a platelet activating factor antagonist in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Azepines; Double-Blind Method; Female; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Activating Factor; Platelet Aggregation Inhibitors; Thienopyridines; Treatment Outcome; Triazoles | 1998 |
693 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and triazoles
| Article | Year |
|---|---|
Interactions of prostanoids with the platelet activating factors.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Guinea Pigs; Heart; Iloprost; In Vitro Techniques; Indomethacin; Myocardial Contraction; Perfusion; Platelet Activating Factor; Prostaglandins; Sulfonamides; Thromboxane A2; Thromboxane B2; Triazoles | 1992 |
Modulation of antigen- and ischemia-induced effects by the platelet-activating factor antagonist WEB-2086 in isolated sensitized rat hearts.
Topics: Anaphylaxis; Animals; Antigens; Azepines; Chromatography, High Pressure Liquid; Chromones; Coronary Circulation; Heart; Histamine Release; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion; Platelet Activating Factor; Pressure; Rats; Rats, Wistar; Triazoles | 1992 |
Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart.
Topics: Amino Acid Sequence; Animals; Azepines; Base Sequence; Blotting, Northern; Cloning, Molecular; DNA; Electrophysiology; Gene Expression; Heart; Heart Ventricles; Humans; Male; Middle Aged; Molecular Sequence Data; Oligodeoxyribonucleotides; Oocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA; Triazoles; Xenopus | 1992 |
Inhibition of platelet-activating factor fails to limit ischemia and reperfusion-induced myocardial damage.
Topics: Animals; Azepines; Blood Pressure; Coronary Circulation; Dogs; Heart Rate; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Platelet Activating Factor; Platelet Aggregation; Triazoles | 1992 |
Endothelium-dependent effects of platelet-activating factor in the coronary circulation.
Topics: Animals; Azepines; Coronary Circulation; Coronary Vessels; Diterpenes; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Ginkgolides; Hemodynamics; Injections, Intra-Arterial; Injections, Intravenous; Lactones; Platelet Activating Factor; Saponins; Triazoles; Vascular Resistance; Vasoconstriction; Vasodilation | 1992 |
PAF-acether induced arterial thrombosis and the effect of specific antagonists.
Topics: Acetyltransferases; Animals; Azepines; Blood Platelets; Down-Regulation; Guinea Pigs; Hydrogen Peroxide; Hydrolases; Mesenteric Arteries; Phenylmethylsulfonyl Fluoride; Platelet Activating Factor; Thienopyridines; Thrombosis; Triazoles | 1992 |
Inhibition of vincristine-induced retinal impairments by a specific PAF antagonist.
Topics: Animals; Azepines; Electroretinography; Organ Culture Techniques; Perfusion; Photic Stimulation; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Retinal Diseases; Tetrazoles; Thienopyridines; Triazoles; Vincristine | 1992 |
PAF receptor blockade inhibits lung vascular changes in the rat monocrotaline model.
Topics: Animals; Azepines; Blood Pressure; Hydroxyproline; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pulmonary Artery; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thymidine; Triazoles | 1992 |
Platelet activating factor mediates interleukin-2-induced lung injury in the rat.
Topics: Animals; Azepines; Blood Pressure; Interleukin-2; Leukocyte Count; Lung Diseases; Male; Peroxidase; Platelet Activating Factor; Platelet Count; Rats; Rats, Inbred Strains; Thromboxane B2; Triazoles; Tumor Necrosis Factor-alpha | 1992 |
Neutrophil migration across monolayers of cytokine-prestimulated endothelial cells: a role for platelet-activating factor and IL-8.
Topics: Antigens, Surface; Azepines; Cell Adhesion; Cell Movement; Cells, Cultured; Endothelium, Vascular; Female; Furans; Humans; Interleukin-8; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pregnancy; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Stimulation, Chemical; Triazoles; Tumor Necrosis Factor-alpha; Umbilical Veins | 1992 |
Effects of WEB 2086, an antagonist to the receptor for platelet-activating factor (PAF), on PAF-induced responses in the horse.
Topics: Animals; Azepines; Capillary Permeability; Cell Migration Inhibition; Cell Movement; Dose-Response Relationship, Drug; Horses; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1992 |
Existence of PAF receptors in human platelets and human lung tissue but not in the human myocardium.
Topics: Azepines; Blood Platelets; Coronary Vessels; Depression, Chemical; Humans; In Vitro Techniques; Isometric Contraction; Lung; Middle Aged; Myocardial Contraction; Myocardium; Platelet Activating Factor; Platelet Membrane Glycoproteins; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1992 |
Platelet-activating factor inhibits proteoglycan synthesis and enhances neutrophil-mediated proteoglycan degradation in cartilage explants.
Topics: Animals; Azepines; Cartilage, Articular; Cattle; Cells, Cultured; Granulocyte-Macrophage Colony-Stimulating Factor; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteoglycans; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sulfur Radioisotopes; Triazoles; Tumor Necrosis Factor-alpha | 1992 |
Immune-complex alveolitis in the rat: evidence for platelet activating factor and leukotrienes as mediators of the vascular lesions.
Topics: Alveolitis, Extrinsic Allergic; Animals; Azepines; Bronchoalveolar Lavage Fluid; Dinoprostone; Diterpenes; Econazole; Ginkgolides; Hemoglobins; Hemorrhage; Indomethacin; Lactones; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Propionates; Quinolines; Rats; Rats, Inbred Strains; Thromboxanes; Triazoles | 1992 |
Dexamethasone-induced gastric mucosal damage in the rat: possible role of platelet-activating factor.
Topics: Animals; Azepines; Dexamethasone; Diterpenes; Gastric Mucosa; Ginkgolides; Lactones; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prostaglandins; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles | 1992 |
Characterization of the antagonist activity of the PAF antagonists RP 59227 and WEB 2086 on elicited guinea pig peritoneal macrophages. Evidence for variable affinities and kinetics.
Topics: Animals; Azepines; Guinea Pigs; Humans; Kinetics; Macrophages; Male; Neutrophils; Peritoneum; Platelet Activating Factor; Pyridines; Superoxides; Thiazoles; Triazoles | 1992 |
Reversible or irreversible modification of [3H]PAF binding on rabbit platelet membranes differentiates various PAF receptor antagonists.
Topics: Animals; Azepines; Blood Platelets; Cell Membrane; Dioxolanes; Diterpenes; Furans; Ginkgolides; Lactones; Molecular Structure; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridinium Compounds; Quinolinium Compounds; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Tritium | 1992 |
Effects of nedocromil sodium and WEB 2086 on chemoattractant-stimulated neutrophil migration through cellular and noncellular barriers.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Azepines; Cells, Cultured; Chemotaxis, Leukocyte; Endothelium, Vascular; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Nedocromil; Neutrophils; Platelet Activating Factor; Quinolones; Triazoles | 1992 |
The role of complement, platelet-activating factor and leukotriene B4 in a reversed passive Arthus reaction.
Topics: Animals; Arthus Reaction; Azepines; Complement System Proteins; Edema; Isoquinolines; Leukotriene B4; Platelet Activating Factor; Rabbits; Radioimmunoassay; Receptors, Complement; Tetrazoles; Triazoles; Zymosan | 1992 |
Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor.
Topics: Azepines; Blood Platelets; Enzyme Activation; Erythrocytes; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1992 |
Specific binding sites of platelet activating factor on the intact bovine cerebral microvascular endothelial cells and antagonism of drugs.
Topics: Animals; Azepines; Binding Sites; Brain; Capillaries; Cattle; Cells, Cultured; Endothelium, Vascular; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1992 |
Enhancement by staurosporine of platelet-activating factor formation in N-formyl peptide-challenged human neutrophils is mediated by intracellular platelet-activating factor binding sites.
Topics: Alkaloids; Azepines; Binding Sites; Calcium; Drug Synergism; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staurosporine; Triazoles | 1992 |
[Interference of platelet-activating factor antagonist, BN50739 with the releasing of inflammatory mediators from anaphylactic lung of guinea pig].
Topics: Alveolitis, Extrinsic Allergic; Animals; Azepines; Female; Guinea Pigs; Histamine; Lung; Male; Ovalbumin; Platelet Activating Factor; Prostaglandins F; SRS-A; Thromboxane B2; Triazoles | 1992 |
Triazolam and PAF inhibition.
Topics: Azepines; Clinical Trials as Topic; Drug Administration Schedule; Humans; Platelet Activating Factor; Triazolam; Triazoles | 1992 |
Leukotriene B4 mediates shear rate-dependent leukocyte adhesion in mesenteric venules.
Topics: Animals; Antigens, CD; Azepines; Benzopyrans; Cats; CD18 Antigens; Endothelium, Vascular; Indoles; Leukocytes; Leukotriene B4; Mesenteric Veins; Platelet Activating Factor; Receptors, Leukocyte-Adhesion; Triazoles; Venules | 1992 |
Interference of azelastine with anaphylaxis induced by ovalbumin challenge in actively sensitized rats.
Topics: Anaphylaxis; Animals; Azepines; Dihydropyridines; Dose-Response Relationship, Drug; Hematocrit; Histamine H1 Antagonists; Leukocyte Count; Male; Meclizine; Ovalbumin; Phthalazines; Platelet Activating Factor; Platelet Count; Rats; Rats, Inbred Strains; Terfenadine; Triazoles | 1992 |
[Effects of anti-PAF agents on nasal response after allergen challenge in guinea pigs].
Topics: Airway Resistance; Allergens; Animals; Azepines; Guinea Pigs; Histamine H1 Antagonists; Male; Nasal Provocation Tests; Nose; Phthalazines; Platelet Activating Factor; Triazoles | 1992 |
Influence of platelet activating factor antagonists on the protamine sulphate stimulated release of histamine from peritoneal mast cells of rats in vitro.
Topics: Acetophenones; Animals; Azepines; Diterpenes; Ginkgolides; Histamine Release; Humans; In Vitro Techniques; Ketotifen; Lactones; Male; Mast Cells; Peritoneal Cavity; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Protamines; Rats; Rats, Inbred Strains; Triazoles | 1992 |
Regulation of hepatic glycogenolysis and vasoconstriction during antigen-induced anaphylaxis.
Topics: Anaphylaxis; Animals; Antigens; Azepines; Eicosanoids; Epitopes; Female; Glycogen; Liver; Nitric Oxide; Ovalbumin; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles; Vasoconstriction | 1992 |
The role of nitric oxide and platelet-activating factor in the inhibition by endotoxin of pentagastrin-stimulated gastric acid secretion.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Azepines; Endotoxins; Female; Gastric Acid; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentagastrin; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles | 1992 |
Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor.
Topics: Animals; Arthus Reaction; Azepines; Capillary Permeability; Disease Models, Animal; Female; Guinea Pigs; Male; Molecular Structure; Ovalbumin; Pancreatitis; Platelet Activating Factor; Rabbits; Rats; Rats, Inbred Strains; Skin; Skin Diseases; Triazoles | 1992 |
Platelet activating factor and systemic anaphylaxis in Nippostrongylus brasiliensis-sensitized rats: differential effects of PAF antagonists.
Topics: Anaphylaxis; Animals; Azepines; Blood Proteins; Diterpenes; Evans Blue; Ginkgolides; Hemodynamics; Lactones; Male; Microspheres; Nippostrongylus; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles | 1992 |
PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats.
Topics: Animals; Azepines; Endothelins; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Lung; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pulmonary Circulation; Rats; Triazoles; Vasoconstriction | 1992 |
Role of platelet-activating factor in the development of endothelial dysfunction in hemorrhagic hypotension and retransfusion.
Topics: Animals; Azepines; Blood Transfusion; Cats; Cerebrovascular Disorders; Endothelium, Vascular; Hemorrhage; Hypotension; Male; Platelet Activating Factor; Triazoles | 1992 |
Differential effects of WEB 2086 and SRI 63-441 on TNF-alpha-induced alterations in cardiopulmonary function.
Topics: Animals; Azepines; ErbB Receptors; Heart; Indomethacin; Lipids; Lung; Platelet Activating Factor; Platelet Aggregation; Quinolinium Compounds; Swine; Triazoles; Tumor Necrosis Factor-alpha | 1992 |
Platelet-activating factor antagonists limit glycine changes and behavioral deficits after brain trauma.
Topics: Animals; Azepines; Behavior, Animal; Body Water; Brain; Brain Injuries; Cations; Dialysis; Diterpenes; Ginkgolides; Glycine; Lactones; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles | 1992 |
Platelet-activating factor antagonists in experimental shock.
Topics: Acid-Base Equilibrium; Animals; Azepines; Blood Pressure; Electrocardiography; Endotoxins; Hyperkalemia; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Shock; Triazoles | 1992 |
Activation of leukocytes with complement C5a is associated with prostanoid-dependent constriction of large arteries in atherosclerotic monkeys in vivo.
Topics: Animals; Arteries; Arteriosclerosis; Azepines; Bridged Bicyclo Compounds, Heterocyclic; Complement C5a; Fatty Acids, Unsaturated; Hemodynamics; Hydrazines; Leukocytes; Lipids; Macaca fascicularis; Male; Platelet Activating Factor; Prostaglandins; Thromboxane A2; Triazoles; Vasoconstriction | 1992 |
Inflammation and platelet-activating factor production during hepatic ischemia/reperfusion.
Topics: Alanine Transaminase; Allopurinol; Animals; Azepines; Gadolinium; Hepatitis; Ischemia; Leukocytes; Liver; Male; Necrosis; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Triazoles | 1992 |
Role of platelet-activating factor in hepatic responses after bile duct ligation in rats.
Topics: Animals; Azepines; Bile Ducts; Cholestasis; Diterpenes; Endotoxins; Ginkgolides; Kupffer Cells; Lactones; Ligation; Lipopolysaccharides; Liver; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles | 1992 |
The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils.
Topics: Adult; Asthma; Azepines; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Eosinophils; Female; Humans; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; SRS-A; Triazoles | 1992 |
Interactions of tumor necrosis factor with local and systemic factors in fetal rat limb bones.
Topics: Animals; Azepines; Bone and Bones; Bone Resorption; Culture Techniques; Dexamethasone; Hindlimb; Indomethacin; Interferon-gamma; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Parathyroid Hormone; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sialoglycoproteins; Transforming Growth Factor beta; Triazoles; Tumor Necrosis Factor-alpha | 1992 |
Influence of a platelet-activating factor antagonist on severe pancreatitis in two experimental models.
Topics: Animals; Ascites; Azepines; Male; Pancreatitis; Platelet Activating Factor; Rats; Rats, Wistar; Survival Rate; Triazoles | 1992 |
Aggregation of human polymorphonuclear leukocytes by endothelin: role of platelet-activating factor.
Topics: Azepines; Calcium; Cell Aggregation; Centrifugation, Density Gradient; Cytosol; Diterpenes; Dose-Response Relationship, Drug; Endothelins; Ginkgolides; Humans; Lactones; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Triazoles | 1992 |
Effects of the PAF antagonists BN50726 and BN50739 on arrhythmogenesis and extent of necrosis during myocardial ischaemia/reperfusion in rabbits.
Topics: Animals; Arrhythmias, Cardiac; Azepines; Blood Pressure; Electrocardiography; Heart Rate; Hemodynamics; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Necrosis; Platelet Activating Factor; Rabbits; Thienopyridines; Triazoles | 1992 |
Pulmonary vascular reactivity: effect of PAF and PAF antagonists.
Topics: Angiotensin II; Animals; Azepines; Hypoxia; In Vitro Techniques; Male; Phospholipid Ethers; Platelet Activating Factor; Pulmonary Circulation; Pulmonary Edema; Quinolinium Compounds; Rats; Rats, Sprague-Dawley; Triazoles; Vasoconstriction; Vasodilation | 1992 |
Platelet-activating factor as an intercellular signal in neutrophil-dependent platelet activation.
Topics: Amino Acid Sequence; Animals; Azepines; Blood Platelets; Cells, Cultured; Fibrinogen; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Signal Transduction; Thromboxane A2; Triazoles | 1992 |
The effects of a PAF antagonist on ischemic myocardial damage and arrhythmia in the dog.
Topics: Animals; Arrhythmias, Cardiac; Azepines; Coronary Disease; Dogs; Myocardial Reperfusion Injury; Platelet Activating Factor; Tachycardia; Triazoles; Ventricular Fibrillation | 1992 |
Mechanisms of the cardioprotective actions of WEB-2170, bepafant, a platelet activating factor antagonist, in myocardial ischemia and reperfusion.
Topics: Animals; Azepines; Cats; Cell Adhesion; Coronary Disease; Creatine Kinase; Endothelium, Vascular; Heart; Hemodynamics; Male; Myocardial Reperfusion Injury; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Triazoles | 1992 |
Burn-induced gastric mucosal hemodynamic disturbance in the rat. Role of platelet-activating factor.
Topics: Animals; Azepines; Blood Pressure; Burns; Gastric Mucosa; Hemodynamics; Hemoglobins; Male; Oxygen; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Inbred Strains; Regional Blood Flow; Thiazoles; Thiazolidines; Triazoles | 1992 |
Role of platelet-activating factor in pancreatitis-associated acute lung injury in the rat.
Topics: Animals; Azepines; Bronchoalveolar Lavage Fluid; Diterpenes; Eicosanoids; Enzymes; Ginkgolides; Lactones; Lung; Pancreatitis; Platelet Activating Factor; Rats; Triazoles | 1992 |
Studies on xenograft rejection: the role of leukocytes and prostaglandins and their modulation by the hetrazepine WEB 2086BS.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Erythrocyte Count; Graft Rejection; Hemagglutinins; Hemoperfusion; Humans; Kidney Transplantation; Leukocytes; Platelet Activating Factor; Swine; Thromboxane B2; Transplantation, Heterologous; Triazoles | 1992 |
Effect of WEB 2086 on myocardial infarct size and regional blood flow in the dog.
Topics: Animals; Azepines; Cardiac Output; Coronary Disease; Disease Models, Animal; Dogs; Myocardial Infarction; Myocardium; Platelet Activating Factor; Regional Blood Flow; Triazoles | 1992 |
WEB 2086 inhibits neutrophil dependent increases in coronary resistance in blood perfused rabbit heart.
Topics: Animals; Azepines; Disease Models, Animal; Myocardial Reperfusion Injury; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rabbits; Triazoles; Vascular Resistance | 1992 |
Inhibition of neutrophil respiratory burst and degranulation responses to platelet-activating factor by antagonists WEB 2086, CV 6209 and CV 3988.
Topics: Azepines; Cell Degranulation; Cell Survival; Humans; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Pyridinium Compounds; Respiratory Burst; Triazoles | 1992 |
Release of platelet-activating factor is important for the respiratory burst induced in human eosinophils by opsonized particles.
Topics: Azepines; Eosinophils; Humans; In Vitro Techniques; Kinetics; Oxygen Consumption; Phospholipases A; Platelet Activating Factor; Triazoles; Zymosan | 1992 |
Inhibition of aeroallergen-induced bronchial eosinophilia by azelastine in guinea pigs.
Topics: Administration, Oral; Animals; Azepines; Bronchodilator Agents; Dose-Response Relationship, Drug; Guinea Pigs; Leukocyte Count; Leukocytes, Mononuclear; Male; Methylprednisolone; Phthalazines; Platelet Activating Factor; Pulmonary Eosinophilia; Theophylline; Triazoles | 1992 |
Mast cell mediators prostaglandin-D2 and histamine activate human eosinophils.
Topics: Azepines; Calcimycin; Calcium; Cytosol; Dinoprostone; Eosinophils; Histamine; Histamine Antagonists; Humans; In Vitro Techniques; Lung; Mast Cells; Neutrophils; Piperidines; Platelet Activating Factor; Prostaglandin D2; Secretory Rate; SRS-A; Triazoles | 1992 |
Attenuation of platelet-activating factor-induced airway responses with methylprednisolone succinate in sheep.
Topics: Airway Resistance; Animals; Azepines; Bronchoconstriction; Carbachol; Eicosanoids; Indomethacin; Methylprednisolone Hemisuccinate; Platelet Activating Factor; Propionates; Quinolines; Respiratory Mechanics; Sheep; SRS-A; Triazoles | 1992 |
RP 59227, a novel PAF receptor antagonist: effects in guinea pig models of airway hyperreactivity.
Topics: Animals; Antigens; Azepines; Bronchial Hyperreactivity; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Guinea Pigs; Male; Ovalbumin; Platelet Activating Factor; Pyridines; Thiazoles; Triazoles | 1992 |
Platelet-activating factor reduces spinal cord blood flow and causes behavioral deficits after intrathecal administration in rats through a specific receptor mechanism.
Topics: Animals; Azepines; Blood Pressure; Dose-Response Relationship, Drug; Injections, Spinal; Male; Motor Activity; Platelet Activating Factor; Rats; Rats, Inbred Strains; Spinal Cord; Triazoles | 1992 |
Hapten synthesis for (+)-6-(2-chlorophenyl)-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5-tet rahydro-8H-pyrido[4',3':4,5]thieno[3,2-f] triazolo[4,3-a][1,4]diazepine (E6123).
Topics: Azepines; Chromatography; Haptens; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Platelet Activating Factor; Radioimmunoassay; Triazoles | 1992 |
Hemodynamic effects of endotoxin and platelet activating factor in cirrhotic rats.
Topics: Animals; Azepines; Blood Pressure; Diterpenes; Endotoxins; Ginkgolides; Heart Rate; Hemodynamics; Lactones; Liver Cirrhosis, Experimental; Male; Platelet Activating Factor; Portal System; Rats; Rats, Inbred Strains; Triazoles | 1992 |
1,5-Benzodiazepines. X. Dialkylamino substituted 1,5-benzodiazepine and [1,2,4]triazolo [4,3-a][1,5] benzodiazepine derivatives with inhibitory activity on PAF-induced platelet aggregation.
Topics: Benzodiazepines; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Triazoles | 1992 |
Differential inhibition by the PAF receptor antagonist, WEB 2170, of allergic inflammation in single sensitized and boosted mice.
Topics: Animals; Antigens; Azepines; Dose-Response Relationship, Drug; Edema; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Platelet Activating Factor; Triazoles | 1992 |
Platelet-activating factor stimulates phospholipase C activity in human endometrium.
Topics: Adult; Azepines; Cells, Cultured; Chromatography, Ion Exchange; Dose-Response Relationship, Drug; Endometrium; Female; Humans; Inositol; Inositol Phosphates; Middle Aged; Platelet Activating Factor; Time Factors; Triazoles; Type C Phospholipases | 1992 |
Effect of BN 52256 and other mediator antagonists on ouabain-induced ventricular fibrillation in sensitized guinea-pigs and on ischemia-induced fibrillation in rats.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Azepines; Clemastine; Coronary Disease; Coronary Vessels; Guinea Pigs; Organoselenium Compounds; Ouabain; Piperidines; Platelet Activating Factor; Propranolol; Rats; Triazoles; Umbelliferones; Ventricular Fibrillation | 1992 |
Oxidatively fragmented phosphatidylcholines activate human neutrophils through the receptor for platelet-activating factor.
Topics: Azepines; Cell Adhesion; Furans; Humans; Hydrolysis; In Vitro Techniques; Indicators and Reagents; Kinetics; Neutrophils; Oxidation-Reduction; Phosphatidylcholines; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1991 |
LTB4, a potent chemotactic factor for purified guinea-pig eosinophils: interference of PAF-acether antagonists.
Topics: Animals; Azepines; Chemotaxis, Leukocyte; Diterpenes; Eosinophils; Female; Ginkgolides; Guinea Pigs; In Vitro Techniques; Lactones; Leukotriene B4; Male; Platelet Activating Factor; Triazoles | 1991 |
Platelet activating factor-induced shock and intestinal necrosis in the rat: role of endogenous platelet-activating factor and effect of saline infusion.
Topics: Animals; Azepines; Intestine, Large; Isotonic Solutions; Male; Necrosis; Peroxidase; Platelet Activating Factor; Rats; Rats, Inbred Strains; Shock; Sodium Chloride; Triazoles | 1991 |
The platelet activating factor receptor antagonist, RP 59227, blocks platelet activating factor receptors mediating liberation of reactive oxygen species in guinea pig macrophages and human polymorphonuclear leukocytes.
Topics: Animals; Azepines; Glyceryl Ethers; Guinea Pigs; Humans; Luminescent Measurements; Macrophages; Male; Neutrophils; Oxygen; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles | 1991 |
Regulation of eicosanoid generation in activated macrophages.
Topics: Animals; Azepines; Dexamethasone; Epoprostenol; Macrophage Activation; Macrophages; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridinium Compounds; Rabbits; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1991 |
Platelet-activating factor synergizes with phorbol myristate acetate in activating phospholipase D in the human promonocytic cell line U937. Evidence for different mechanisms of activation.
Topics: Azepines; Cell Line; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Glycerophospholipids; Humans; Kinetics; Monocytes; Phosphatidic Acids; Phosphatidylinositols; Phospholipase D; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Tetradecanoylphorbol Acetate; Triazoles; Type C Phospholipases | 1991 |
Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist.
Topics: Animals; Azepines; Blood Platelets; Bronchoconstriction; Guinea Pigs; Humans; Injections, Intravenous; Leukopenia; Male; Mice; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thrombocytopenia; Triazoles | 1991 |
Pharmacology of a potent platelet-activating factor antagonist: Ro 24-4736.
Topics: Animals; Azepines; Binding Sites; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Dogs; Guinea Pigs; Humans; Male; Phenanthridines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazines; Triazoles | 1991 |
Mechanisms of platelet activating factor-induced changes in sheep tracheal blood flow.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Chromones; Cimetidine; Dose-Response Relationship, Drug; Female; Indomethacin; Methacholine Compounds; Muscle Tonus; Muscle, Smooth; Nedocromil; Platelet Activating Factor; Pyrilamine; Quinolones; Regional Blood Flow; Sheep; Trachea; Triazoles; Vascular Resistance | 1991 |
Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.
Topics: Amino Acid Sequence; Animals; Azepines; Base Sequence; Blotting, Northern; Cell Line; Cloning, Molecular; DNA; Guinea Pigs; Humans; Leukocytes; Membrane Potentials; Molecular Sequence Data; Ovum; Phosphatidylinositols; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Conformation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Triazoles; Xenopus laevis | 1991 |
Resistance and exchange microvessels are modulated by different PAF receptors.
Topics: Animals; Arterioles; Azepines; Capillary Permeability; Cheek; Cricetinae; Dose-Response Relationship, Drug; Kinetics; Male; Mesocricetus; Mouth Mucosa; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Vasoconstriction | 1991 |
The effect of platelet-activating factor on the generation of superoxide anion in human eosinophils and neutrophils.
Topics: Adult; Asthma; Azepines; Calcium; Chelating Agents; Dose-Response Relationship, Drug; Eosinophils; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Neutrophils; Platelet Activating Factor; Rhinitis; Superoxides; Triazoles | 1991 |
Molecular and cellular actions of platelet-activating factor in rat heart cells.
Topics: Animals; Azepines; Cells, Cultured; Dose-Response Relationship, Drug; Heart; Myocardial Contraction; Phosphatidylinositols; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1991 |
Receptor-mediated increase in cytosolic calcium in LLC-PK1 cells by platelet activating factor and thromboxane A2.
Topics: Animals; Azepines; Calcium; Carbazoles; Cell Line; Cytosol; Kidney Tubules, Proximal; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Prostaglandin; Receptors, Thromboxane; Tetrazoles; Thienopyridines; Thromboxane A2; Triazoles | 1991 |
Species-dependent differences of high affinity [3H]PAF-binding to platelets from humans and pigs and its inhibition by selected antagonists.
Topics: Animals; Azepines; Blood Platelets; Diterpenes; Ginkgolides; Humans; Lactones; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Species Specificity; Swine; Triazoles | 1991 |
PAF-mediated platelet adhesion to endothelial cells induced by FMLP-stimulated leukocytes.
Topics: Azepines; Endothelium, Vascular; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Adhesiveness; Triazoles; Umbilical Veins | 1991 |
Quantitative assessment of increased airway microvascular permeability to 125I-labelled plasma fibrinogen induced by platelet activating factor and bradykinin.
Topics: Animals; Autoradiography; Azepines; Bradykinin; Capillary Permeability; Fibrinogen; Guinea Pigs; Iodine Radioisotopes; Lung; Male; Paraffin Embedding; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pulmonary Circulation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Trachea; Triazoles | 1991 |
1-O-hexadecyl-2-acetyl-sn-glycero-3-phospho (N,N,N trimethyl) hexanolamine: an analogue of platelet-activating factor with partial agonist activity.
Topics: Animals; Azepines; Blood Platelets; Calcium; Guinea Pigs; In Vitro Techniques; Macrophages; Male; Oxygen Consumption; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Signal Transduction; Superoxides; Triazoles | 1991 |
Effects of antiplatelet agents on platelet aggregation induced by platelet--activating factor (PAF) in human whole blood.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Azepines; Dose-Response Relationship, Drug; Humans; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1991 |
Differential actions of platelet-activating factor (PAF) receptor antagonists on the vasodilator and vasoconstrictor effects of PAF in the rat perfused heart.
Topics: Animals; Azepines; Coronary Vessels; Heart; In Vitro Techniques; Indoles; Piperazines; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridinium Compounds; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Vasoconstriction; Vasodilation | 1991 |
Effects of endothelin-1 on vascular permeability in the conscious rat: interactions with platelet-activating factor.
Topics: Animals; Azepines; Blood Pressure; Capillary Permeability; Diterpenes; Endothelins; Ginkgolides; Hematocrit; In Vitro Techniques; Lactones; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1991 |
Platelet-activating factor may participate in signal transduction processes in rabbit leukocytes.
Topics: Animals; Arachidonic Acid; Azepines; Blood Platelets; Calcimycin; Chloroquine; Female; Kinetics; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Pyridinium Compounds; Rabbits; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Triazoles | 1991 |
Pharmacological properties of YM461, a new orally active platelet-activating factor antagonist.
Topics: Administration, Oral; Animals; Azepines; Blood Platelets; Blood Pressure; Cell Membrane; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Male; Mice; Mice, Inbred ICR; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines; Triazoles | 1991 |
Platelet-activating factor (PAF) receptor antagonists inhibit arachidonic acid induced platelet aggregation in rabbit whole blood.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Azepines; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazoles | 1991 |
Effect of PAF-acether antagonists on active anaphylactic mouse paw edema.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Anaphylaxis; Animals; Aspirin; Azepines; Cimetidine; Dexamethasone; Edema; Male; Meclizine; Methysergide; Mice; Ovalbumin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prednisolone; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetrazoles; Triazoles | 1991 |
Inflammatory edema induced by interactions between IL-1 and the neuropeptide calcitonin gene-related peptide.
Topics: Animals; Azepines; Calcitonin Gene-Related Peptide; Capillary Permeability; Complement C5a; Dinoprostone; Drug Synergism; Edema; Histamine H1 Antagonists; In Vitro Techniques; Interleukin-1; Male; Neutrophils; Platelet Activating Factor; Protein Synthesis Inhibitors; Rabbits; Triazoles | 1991 |
Histamine, leukotriene D4 and platelet-activating factor in guinea pig passive cutaneous anaphylaxis.
Topics: Acetophenones; Animals; Autacoids; Azepines; Blood Proteins; Bradykinin; Capillary Permeability; Chlorpheniramine; Cimetidine; Guinea Pigs; Histamine; Male; Methysergide; Passive Cutaneous Anaphylaxis; Platelet Activating Factor; SRS-A; Tetrazoles; Triazoles | 1991 |
Antagonists of embryo-derived platelet-activating factor act by inhibiting the ability of the mouse embryo to implant.
Topics: Animals; Azepines; Blastocyst; Decidua; Embryo Implantation; Embryo Transfer; Epoprostenol; Female; Iloprost; Mice; Mice, Inbred Strains; Platelet Activating Factor; Pregnancy; Quinolinium Compounds; Triazines; Triazoles; Trophoblasts | 1990 |
Inhibition of PAF-induced histamine secretion and bronchoconstriction by WEB 2086.
Topics: Animals; Azepines; Bronchi; Cromolyn Sodium; Guinea Pigs; Histamine Release; In Vitro Techniques; Leukocytes; Male; Muscle, Smooth; Platelet Activating Factor; Rabbits; Triazines; Triazoles | 1990 |
Ro 19-3704 directly inhibits immunoglobulin E-dependent mediator release by a mechanism independent of its platelet-activating factor antagonist properties.
Topics: Animals; Azepines; Diterpenes; Ginkgolides; Glyceryl Ethers; Histamine Release; Humans; Immunoglobulin E; Inositol Phosphates; L-Lactate Dehydrogenase; Lactones; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Substance P; Synovial Fluid; Thiazoles; Triazines; Triazoles; Tumor Cells, Cultured | 1990 |
Characterization of cardiovascular events mediated by platelet activating factor during systemic anaphylaxis.
Topics: Anaphylaxis; Animals; Arrhythmias, Cardiac; Azepines; Blood Pressure; Cardiac Output; Cimetidine; Electrocardiography; Female; Guinea Pigs; Heart Rate; Hemodynamics; Histamine; Male; Myocardial Contraction; Ovalbumin; Platelet Activating Factor; Pyrilamine; Triazoles | 1990 |
Evidence for platelet-activating factor as a late-phase mediator of chronic pancreatitis in the rat.
Topics: Amylases; Animals; Azepines; Chronic Disease; Diterpenes; Ginkgolides; Lactones; Ligation; Male; Pancreas; Pancreatic Ducts; Pancreatitis; Platelet Activating Factor; Rats; Rats, Inbred Strains; Time Factors; Triazoles | 1990 |
Effects of platelet-activating factor on myocardial contraction and myocardial relaxation of isolated perfused guinea pig hearts.
Topics: Animals; Azepines; Calcium; Coronary Circulation; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Perfusion; Platelet Activating Factor; Triazoles | 1990 |
Gastric mucosal damage by ethanol is mediated by substance P and prevented by ketotifen, a mast cell stabilizer.
Topics: Animals; Azepines; Cimetidine; Ethanol; Gastric Acid; Gastric Mucosa; Gastrins; Hydroxyzine; In Vitro Techniques; Ketotifen; Leukotriene B4; Male; Mast Cells; Pepsin A; Peptide Fragments; Platelet Activating Factor; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; SRS-A; Substance P; Triazoles | 1991 |
Primed neutrophils injure rat lung through a platelet-activating factor-dependent mechanism.
Topics: Animals; Azepines; Lipopolysaccharides; Lung; Lung Diseases; Male; Neutrophils; Nitroblue Tetrazolium; Oligopeptides; Peroxidase; Platelet Activating Factor; Rats; Rats, Inbred Strains; Serum Albumin; Staining and Labeling; Triazoles | 1991 |
Demonstration of platelet activating factor receptor in guinea pig kidney.
Topics: Animals; Azepines; Blotting, Northern; Cell Membrane; Guinea Pigs; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Medulla; Kinetics; Membrane Proteins; Platelet Activating Factor; Platelet Membrane Glycoproteins; Poly A; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA; RNA, Messenger; Triazoles | 1991 |
The effect of inhibitors of platelet aggregation on the metabolism of platelet-activating factor (PAF) in washed rabbit platelets.
Topics: Animals; Azepines; Blood Platelets; Chromatography, High Pressure Liquid; Iloprost; Kinetics; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Quinolinium Compounds; Rabbits; Triazoles; Tritium | 1991 |
Infarct reduction by the platelet activating factor antagonist apafant in rats.
Topics: Animals; Azepines; Cerebral Infarction; Cerebrovascular Circulation; Platelet Activating Factor; Rats; Rats, Inbred F344; Triazoles | 1992 |
Future horizons of lung preservation by application of a platelet-activating factor antagonist compared with current clinical standards. Euro-Collins flush perfusion versus donor core cooling.
Topics: Animals; Azepines; Cold Temperature; Dogs; Epoprostenol; Heart-Lung Transplantation; Hemodynamics; Hypertonic Solutions; Organ Preservation; Oxygen; Platelet Activating Factor; Pulmonary Circulation; Triazoles | 1992 |
Beneficial effects of TCV-309, a novel potent and selective platelet activating factor antagonist in endotoxin and anaphylactic shock in rodents.
Topics: Anaphylaxis; Animals; Azepines; Furans; Hemolysis; Humans; Hypotension; Isoquinolines; Male; Microsomes; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridinium Compounds; Rabbits; Rats; Rats, Inbred Strains; Shock, Septic; Tetrahydroisoquinolines; Triazoles | 1992 |
A role for phospholipid-derived inflammatory mediators in intestinal anaphylaxis in the rat.
Topics: Anaphylaxis; Animals; Azepines; Biological Transport; Carbazoles; Dinoprostone; Electrolytes; Female; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Jejunum; Leukotriene Antagonists; Leukotrienes; Phospholipids; Platelet Activating Factor; Propionates; Quinolines; Rats; Thromboxanes; Triazoles | 1992 |
Role of platelet-activating factor in mediating tumor necrosis factor alpha-induced pulmonary vasoconstriction and plasma-lymph protein transport.
Topics: Animals; Azepines; Capillary Permeability; Lymphatic System; Male; Platelet Activating Factor; Pulmonary Veins; Sheep; Triazoles; Tumor Necrosis Factor-alpha; Vasoconstriction | 1991 |
[Effects of the PAF antagonist WEB 2086 on hypoxia and angiotensin II-induced pulmonary vasoconstriction in the isolated perfused rat lung].
Topics: Angiotensin II; Animals; Azepines; Hypoxia; Organ Culture Techniques; Perfusion; Platelet Activating Factor; Pulmonary Circulation; Rats; Triazoles; Vasoconstriction | 1991 |
Cell adhesion by membrane-bound paf-acether.
Topics: Animals; Azepines; Calcimycin; Cell Adhesion; Diterpenes; Ginkgolides; Humans; In Vitro Techniques; Lactones; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Triazoles; Zymosan | 1991 |
Pharmacological effects of oral E6123, a novel PAF antagonist, on biological changes induced by PAF inhalation in guinea pigs.
Topics: Administration, Oral; Analysis of Variance; Animals; Asthma; Azepines; Bronchial Hyperreactivity; Bronchoconstriction; Calcium; Eosinophils; Guinea Pigs; Lung; Male; Platelet Activating Factor; Triazoles | 1991 |
Effect of platelet-activating factor on porcine pulmonary blood vessels in vitro.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Calcimycin; Diterpenes; Eicosanoids; Ginkgolides; In Vitro Techniques; Lactones; Male; Muscle Contraction; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pulmonary Circulation; Radioimmunoassay; SRS-A; Swine; Thromboxane B2; Triazoles | 1991 |
Mechanisms of platelet-activating factor-induced electrolyte transport in the rat jejunum.
Topics: Animals; Arachidonic Acids; Azepines; Biological Transport, Active; Chlorides; Dinoprostone; Eicosanoic Acids; Electrophysiology; Female; Indomethacin; Jejunum; Platelet Activating Factor; Quinacrine; Rats; Triazoles | 1991 |
B-cell activation and regulation of immunoglobulin synthesis by platelet activating factor.
Topics: Azepines; B-Lymphocytes; Calcium; Cell Differentiation; Cell Line; Inositol; Lymphocyte Activation; Phospholipid Ethers; Platelet Activating Factor; Receptors, Antigen, B-Cell; Triazoles | 1991 |
Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat.
Topics: Acetates; Animals; Azepines; Colitis; Inflammation; Platelet Activating Factor; Polyunsaturated Alkamides; Pyridines; Rats; Rats, Inbred Strains; Triazoles | 1991 |
Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig.
Topics: Animals; Aspirin; Azepines; Bronchial Diseases; Bronchoalveolar Lavage Fluid; Escherichia coli; Guinea Pigs; Lipopolysaccharides; Macrophages; Male; Neutrophils; Platelet Activating Factor; Pulmonary Edema; Pyrilamine; Respiratory Hypersensitivity; Triazoles | 1991 |
Effects of platelet activating factor on rat platelets in vivo.
Topics: Adenosine Diphosphate; Animals; Azepines; Blood Platelets; In Vitro Techniques; Leukocytes; Male; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Count; Pulmonary Embolism; Rats; Rats, Inbred Strains; Triazoles | 1991 |
Inhibitory effects of a novel PAF antagonist E6123 on anaphylactic responses in passively and actively sensitized guinea pigs and passively sensitized mice.
Topics: Administration, Inhalation; Anaphylaxis; Animals; Antigens; Asthma; Azepines; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Ovalbumin; Platelet Activating Factor; Propranolol; Pyrilamine; Triazoles | 1991 |
Long time incubation of monocytic U 937 cells with LDL increases specific paf-acether binding and the cellular acetylhydrolase activity.
Topics: Acetylesterase; Azepines; Cell Line; Humans; Lipoproteins, LDL; Macrophages; Monocytes; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Triazoles | 1991 |
Influence of aminophylline and ketotifen in comparison to the lipoxygenase inhibitors NDGA and esculetin and the PAF antagonists WEB 2170 [correction of 2107] and BN 52021 on endothelin-1 induced vaso- and bronchoconstriction.
Topics: Aminophylline; Animals; Azepines; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Diterpenes; Endothelins; Ginkgolides; Guinea Pigs; Ketotifen; Lactones; Lipoxygenase Inhibitors; Lung; Male; Masoprocol; Platelet Activating Factor; Platelet Aggregation Inhibitors; Theophylline; Thromboxane B2; Triazoles; Umbelliferones; Vasoconstriction; Vasoconstrictor Agents | 1991 |
Structure-activity studies on triazolothienodiazepine derivatives as platelet-activating factor antagonists.
Topics: Animals; Azepines; Blood Platelets; Guinea Pigs; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Activation; Structure-Activity Relationship; Triazoles | 1991 |
Pharmacological activities of a novel thienodiazepine derivative as a platelet-activating factor antagonist. Effects on microvascular permeability, hypotension and nephrosis.
Topics: Animals; Azepines; Blood Pressure; Capillary Permeability; Endotoxins; Guinea Pigs; Male; Nephrosis; Platelet Activating Factor; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Inbred Strains; Triazoles | 1991 |
Protective effect of SR 27417, a novel PAF antagonist, on lethal anaphylactic and endotoxin-induced shock in mice.
Topics: Anaphylaxis; Animals; Azepines; Dose-Response Relationship, Drug; Endotoxins; Escherichia coli; Male; Mice; Mice, Inbred Strains; Ovalbumin; Platelet Activating Factor; Shock, Septic; Thiazoles; Triazoles | 1991 |
Inhibition by the PAF antagonist WEB 2086 of PAF induced inositol-1,4,5-trisphosphate production in human platelets.
Topics: Adenosine Diphosphate; Azepines; Blood Platelets; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Platelet Activating Factor; Thrombin; Triazoles | 1991 |
Effects of PAF antagonists on renal vascular escape and tachyphylaxis in perfused rabbit kidney.
Topics: Animals; Azepines; Diterpenes; Female; Gangliosides; Ginkgolides; In Vitro Techniques; Kidney; Kinetics; Lactones; Male; Perfusion; Platelet Activating Factor; Pyridines; Rabbits; Renal Circulation; Tachyphylaxis; Thiazoles; Time Factors; Triazoles | 1991 |
Effect of the hetrazepinoic platelet-activating factor antagonist Bepafant (WEB 2170) in models of active and passive anaphylaxis in mice and guinea pigs.
Topics: Anaphylaxis; Animals; Azepines; Blood Pressure; Guinea Pigs; Lung; Male; Mice; Mice, Inbred Strains; Ovalbumin; Passive Cutaneous Anaphylaxis; Platelet Activating Factor; Propranolol; Pyrilamine; Respiration; Triazoles | 1991 |
Platelet-activating factor type activity in plasma from patients with septicemia and other diseases.
Topics: Adult; Animals; Azepines; Bacteremia; Blood Platelets; C-Reactive Protein; Female; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Platelet Count; Purpura, Thrombocytopenic; Rabbits; Reference Values; Triazoles | 1991 |
Platelet activating factor (PAF) antagonists: development of a highly potent PAF antagonist, TCV-309.
Topics: Animals; Azepines; Humans; Isoquinolines; Molecular Structure; Niacinamide; Platelet Activating Factor; Pyridinium Compounds; Rabbits; Rats; Structure-Activity Relationship; Tetrahydroisoquinolines; Triazoles | 1991 |
PAF antagonists inhibit monocrotaline-induced lung injury and pulmonary hypertension.
Topics: Animals; Azepines; Cardiomegaly; Hypertension, Pulmonary; Lung; Lung Injury; Male; Monocrotaline; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles | 1991 |
Enterolobin induces rat paw oedema independently of PAF-acether.
Topics: Animals; Azepines; Dihydropyridines; Diterpenes; Edema; Ginkgolides; Lactones; Male; Plant Proteins; Platelet Activating Factor; Rats; Rats, Wistar; Triazoles | 1991 |
Characterization of platelet aggregation induced by the human melanoma cell line HMV-I: roles of heparin, plasma adhesive proteins, and tumor cell membrane proteins.
Topics: Antibodies, Monoclonal; Azepines; Blood Coagulation Factors; Calcium; Cells, Cultured; Citrates; Citric Acid; Fibrinogen; Flow Cytometry; Heparin; In Vitro Techniques; Magnesium; Melanoma; Membrane Proteins; Microbial Collagenase; Neuraminidase; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Thrombospondins; Triazoles; Trypsin | 1991 |
Platelet-activating factor (PAF) receptor-mediated calcium mobilization and phosphoinositide turnover in neurohybrid NG108-15 cells: studies with BN50739, a new PAF antagonist.
Topics: Animals; Azepines; Calcium; Calcium Channel Blockers; Cells, Cultured; Gallic Acid; Hybrid Cells; Phosphatidylinositols; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1991 |
[Platelet-activating factor (PAF) antagonists].
Topics: Animals; Azepines; Binding, Competitive; Diterpenes; Furans; Ginkgolides; Humans; Lactones; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1991 |
Effects of platelet-activating factor on beta- and H2-receptor-mediated increase of myocardial contractile force in isolated perfused guinea pig hearts.
Topics: Animals; Azepines; Coronary Circulation; Drug Interactions; Guanidines; Guinea Pigs; Heart Rate; Imidazoles; Impromidine; Isoproterenol; Myocardial Contraction; Platelet Activating Factor; Receptors, Adrenergic, beta; Receptors, Histamine H2; Triazoles | 1991 |
Effect of BN 50739, a new platelet activating factor antagonist, on ischaemia induced ventricular arrhythmias in isolated working rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Azepines; Coronary Disease; Dose-Response Relationship, Drug; Heart; Heart Ventricles; Male; Myocardial Reperfusion; Organ Culture Techniques; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles | 1991 |
Activity of a novel thienodiazepine derivative as a platelet-activating factor antagonist in guinea pig lungs. Effects on platelet-activating factor and allergen induced eosinophil accumulation.
Topics: Aerosols; Animals; Azepines; Bronchoalveolar Lavage Fluid; Eosinophils; Guinea Pigs; Leukocyte Count; Lung; Male; Methylprednisolone; Platelet Activating Factor; Triazoles | 1991 |
Survival of renal allografted dogs after limited therapy with cyclosporine and the PAF antagonist WEB 2170.
Topics: Animals; Azepines; Cyclosporins; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Graft Survival; Immunosuppressive Agents; Kidney Transplantation; Platelet Activating Factor; Triazoles | 1991 |
Action of the racemate and the isomers of the platelet-activating factor antagonist bepafant (WEB 2170) after oral administration to guinea-pigs and rats.
Topics: Administration, Oral; Animals; Azepines; Blood Pressure; Dose-Response Relationship, Drug; Guinea Pigs; Male; Platelet Activating Factor; Pulmonary Ventilation; Rats; Rats, Inbred Strains; Stereoisomerism; Structure-Activity Relationship; Time Factors; Triazoles | 1991 |
Platelet-leukocyte interaction in adhesion to endothelial cells induced by platelet-activating factor in vitro.
Topics: Adenine; Animals; Azepines; Blood Platelets; Cell Adhesion; Diterpenes; Endothelium, Vascular; Female; Ginkgolides; Humans; In Vitro Techniques; Lactones; Leukocytes; Neutrophils; Platelet Activating Factor; Platelet Adhesiveness; Pregnancy; Rabbits; Thiazoles; Triazoles; Umbilical Veins | 1991 |
Biosynthesis of platelet activating factor (PAF) by an osteosarcoma cell line (UMR 106).
Topics: Animals; Azepines; Cell Line; Enzyme Activation; Kinetics; Osteosarcoma; Phospholipases A; Platelet Activating Factor; Platelet Aggregation; Rats; Sarcoma, Experimental; Triazoles | 1991 |
Thrombin-induced leukopenia and thrombocytopenia are attenuated by PAF antagonist WEB 2086.
Topics: Animals; Azepines; Carbon Dioxide; Cell Adhesion; Leukocyte Count; Leukopenia; Platelet Activating Factor; Sheep; Thrombin; Thrombocytopenia; Thromboxane B2; Triazoles | 1991 |
A triazolodiazepine platelet activating factor receptor antagonist (WEB 2086) reduces pulmonary dysfunction during endotoxin shock in swine.
Topics: Animals; Azepines; Blood Pressure; Cardiac Output; Dose-Response Relationship, Drug; Endotoxins; Leukocyte Count; Lung; Platelet Activating Factor; Pulmonary Artery; Pulmonary Circulation; Pulmonary Gas Exchange; Salmonella; Shock, Septic; Swine; Swine, Miniature; Tissue Plasminogen Activator; Triazoles; Vascular Resistance | 1991 |
Airway oedema and obstruction in guinea pigs exposed to inhaled endotoxin.
Topics: Aerosols; Airway Obstruction; Animals; Azepines; Dust; Edema; Endotoxins; Gossypium; Guinea Pigs; Male; Platelet Activating Factor; Respiration Disorders; Triazoles | 1991 |
Sustained effects of platelet-activating factor infusion in piglets.
Topics: Animals; Animals, Newborn; Azepines; Female; Hypoxia; Infusions, Intravenous; Male; Platelet Activating Factor; Pulmonary Circulation; Quinolinium Compounds; Swine; Triazoles; Vasoconstriction | 1991 |
The role of platelet activating factor in airway inflammation, airway hyperresponsiveness, and pulmonary function in monkeys.
Topics: Aerosols; Animals; Antigens; Azepines; Bronchoconstriction; Lung; Macaca fascicularis; Male; Methacholine Chloride; Neutrophils; Platelet Activating Factor; Respiratory Physiological Phenomena; Respiratory System; Triazoles | 1991 |
Intraperitoneal injection of human recombinant neutrophil-activating factor/interleukin 8 (hrNAF/IL-8) produces a T cell and eosinophil infiltrate in the guinea pig lung. Effect of PAF antagonist WEB2086.
Topics: Animals; Azepines; Eosinophils; Guinea Pigs; Humans; Injections, Intraperitoneal; Interleukin-8; Kinetics; Lung; Platelet Activating Factor; Pulmonary Alveoli; Recombinant Proteins; Serum Albumin, Bovine; T-Lymphocytes; Triazoles | 1991 |
The involvement of platelet-activating factor in thrombocytopenia and follicular rupture during gonadotropin-induced superovulation in immature rats.
Topics: Animals; Azepines; Chorionic Gonadotropin; Female; Gonadotropins, Equine; Indomethacin; Ovulation; Ovulation Induction; Platelet Activating Factor; Platelet Activation; Platelet Count; Rats; Rats, Inbred Strains; Superovulation; Thrombocytopenia; Triazoles; Vena Cava, Inferior | 1991 |
Inhibition of active anaphylaxis in mice and guinea pigs by the new hetrazepinoic PAF antagonist bepafant (WEB 2170).
Topics: Anaphylaxis; Animals; Azepines; Blood Pressure; Bronchoconstriction; Guinea Pigs; Immunization; Male; Mice; Ovalbumin; Platelet Activating Factor; Propranolol; Pulmonary Ventilation; Pyrilamine; Triazoles | 1991 |
Inhibition of cyclic flow variations and reocclusion after thrombolysis in dogs by a novel antagonist of platelet-activating factor.
Topics: Administration, Oral; Animals; Benzodiazepines; Bleeding Time; Blood Coagulation; Blood Flow Velocity; Coronary Thrombosis; Disease Models, Animal; Dogs; Drug Therapy, Combination; Hemodynamics; Partial Thromboplastin Time; Platelet Activating Factor; Platelet Aggregation; Platelet Count; Prothrombin Time; Recurrence; Tissue Plasminogen Activator; Triazolam; Triazoles | 1991 |
PAF-induced conjunctivitis in the rabbit is mediated by peptido-leukotrienes.
Topics: Animals; Azepines; Conjunctiva; Conjunctivitis; Cyclooxygenase Inhibitors; Dicarboxylic Acids; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Indomethacin; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Rabbits; Second Messenger Systems; Tetrazoles; Thiazoles; Thienopyridines; Triazoles | 1990 |
PAF receptors in guinea-pig and human lung.
Topics: Animals; Asthma; Autoradiography; Azepines; Bronchi; Guinea Pigs; Humans; In Vitro Techniques; Lung; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reference Values; Tissue Distribution; Trachea; Triazoles | 1990 |
Pharmacological actions of Y-24180, a new specific antagonist of platelet activating factor (PAF): II. Interactions with PAF and benzodiazepine receptors.
Topics: Animals; Azepines; Binding, Competitive; Blood Platelets; Brain; Diazepam; Humans; In Vitro Techniques; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, GABA-A; Triazoles | 1990 |
PAF-acether-antagonist WEB 2086 for treatment of chronic idiopathic thrombocytopenia.
Topics: Azepines; Chronic Disease; Drug Evaluation; Humans; Platelet Activating Factor; Thrombocytopenia; Triazoles | 1990 |
Recovery of postischemic brain metabolism and function following treatment with a free radical scavenger and platelet-activating factor antagonists.
Topics: Adenosine Monophosphate; Animals; Azepines; Brain; Creatine; Dimethyl Sulfoxide; Dogs; Electroencephalography; Evoked Potentials, Auditory; Free Radical Scavengers; Glucose; Glycogen; Hydrogen-Ion Concentration; Ischemic Attack, Transient; Kinetics; Oxygen; Phosphocreatine; Platelet Activating Factor; Thienopyridines; Triazoles; Vascular Resistance | 1991 |
Multiparametric flow cytometry of the modulation of tumor cell membrane permeability by developmental antitumor ether lipid SRI 62-834 in EMT6 mouse mammary tumor and HL-60 human promyelocytic leukemia cells.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Division; Cell Membrane Permeability; Flow Cytometry; Furans; Humans; Hydrogen-Ion Concentration; Leukemia, Promyelocytic, Acute; Mammary Neoplasms, Animal; Mice; Phospholipid Ethers; Platelet Activating Factor; Time Factors; Triazoles; Tumor Cells, Cultured | 1991 |
Platelet-activating factor (PAF) antagonist WEB 2086 does not modulate the cytotoxicity of PAF or antitumour alkyl lysophospholipids ET-18-O-methyl and SRI 62-834 in HL-60 promyelocytic leukaemia cells.
Topics: Antineoplastic Agents; Azepines; Calcium; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Furans; Humans; Leukemia, Promyelocytic, Acute; Phospholipid Ethers; Platelet Activating Factor; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured | 1991 |
The involvement of platelet-activating factor in hyperacute xenogeneic rejection and its modulation by the PAF-antagonist WEB 2086BS.
Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Animals; Azepines; Female; Graft Rejection; Hemoperfusion; Humans; Kidney Transplantation; Male; Platelet Activating Factor; Swine; Thromboxane B2; Transplantation, Heterologous; Triazoles | 1991 |
Effects of various barriers on platelet-activating factor-induced neutrophil chemotaxis.
Topics: Azepines; Cell Line; Cell Separation; Cells, Cultured; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Endothelium, Vascular; Epithelium; Filtration; Humans; Microscopy, Electron; Neutrophils; Platelet Activating Factor; Time Factors; Triazoles | 1991 |
Triazolobenzo- and triazolothienodiazepines as potent antagonists of platelet activating factor.
Topics: Animals; Azepines; Benzodiazepines; Blood Platelets; Bronchoconstriction; Chemical Phenomena; Chemistry; Dogs; Guinea Pigs; Male; Molecular Conformation; Molecular Structure; Platelet Activating Factor; Structure-Activity Relationship; Thiophenes; Triazoles | 1991 |
Protective effects of specific platelet-activating factor receptor antagonists in experimental glomerulonephritis.
Topics: Animals; Azepines; Glomerular Filtration Rate; Glomerulonephritis; Hemodynamics; Kidney; Male; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles | 1991 |
Thienotriazolodiazepines as platelet-activating factor antagonists. Steric limitations for the substituent in position 2.
Topics: Animals; Azepines; Guinea Pigs; Indicators and Reagents; Lung; Magnetic Resonance Spectroscopy; Molecular Structure; Platelet Activating Factor; Structure-Activity Relationship; Thiophenes; Triazoles | 1991 |
Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat.
Topics: Animals; Azepines; Disease Models, Animal; Glomerulonephritis, Membranous; Hypercholesterolemia; Male; Metabolic Clearance Rate; Methylprednisolone; Piperazines; Platelet Activating Factor; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Ticlopidine; Triazoles | 1991 |
Stimulation of neutrophil adherence to vascular endothelial cells by histamine and thrombin and its inhibition by PAF antagonists and dexamethasone.
Topics: Animals; Azepines; Cell Adhesion; Cells, Cultured; Dexamethasone; Endothelium, Vascular; Furans; Histamine; Humans; In Vitro Techniques; Indomethacin; Male; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Thrombin; Triazoles | 1991 |
Mechanism of airway narrowing caused by inhaled platelet-activating factor. Role of airway microvascular leakage.
Topics: Administration, Inhalation; Animals; Azepines; Bronchi; Bronchoconstriction; Capillary Permeability; Evans Blue; Guinea Pigs; Lung Compliance; Platelet Activating Factor; Respiratory System; Time Factors; Triazoles | 1991 |
Characterization of platelet-activating factor-induced elevation of cytosolic free-calcium level in neurohybrid NCB-20 cells.
Topics: Animals; Azepines; Calcium; Calcium Channel Blockers; Cerebral Cortex; Cricetinae; Cricetulus; Cytosol; Diterpenes; Gallic Acid; Ginkgolides; Hybrid Cells; Lactones; Mice; Neuroblastoma; Platelet Activating Factor; Quinolinium Compounds; Triazoles | 1991 |
Allergen-induced bronchospasm in passively sensitized guinea pigs: influence of new substances in comparison to reference compounds.
Topics: Acrylates; Allergens; Animals; Azepines; Benzoates; Bronchial Spasm; Disease Models, Animal; Guinea Pigs; Immunization, Passive; Male; Ovalbumin; Phospholipases A; Platelet Activating Factor; Tetrazoles; Thienopyridines; Triazoles | 1991 |
[Involvement of platelet activating factor (PAF) in ovalbumin antigen-induced late asthmatic response and increase of airway hyperresponsiveness in a guinea pig experimental model of asthma].
Topics: Airway Resistance; Animals; Asthma; Azepines; Disease Models, Animal; Guinea Pigs; Hypersensitivity, Delayed; Male; Ovalbumin; Platelet Activating Factor; Triazoles | 1991 |
Platelet-activating factor stimulates a rapid accumulation of inositol (1,4,5)trisphosphate in guinea pig eosinophils: relationship to calcium mobilization and degranulation.
Topics: Animals; Azepines; Calcium; Cell Separation; Cytoplasmic Granules; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Inositol 1,4,5-Trisphosphate; Male; Peritoneal Cavity; Platelet Activating Factor; Second Messenger Systems; Stimulation, Chemical; Time Factors; Triazoles | 1991 |
Bombesin-induced bronchoconstriction in the guinea pig: mode of action.
Topics: Animals; Azepines; Blood Pressure; Bombesin; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Male; Muscle, Smooth; Platelet Activating Factor; Pyrilamine; Trachea; Triazoles | 1991 |
Bradykinin-induced plasma exudation in guinea-pig airways: involvement of platelet activating factor.
Topics: Animals; Azepines; Bradykinin; Edema; Evans Blue; Exudates and Transudates; Guinea Pigs; Male; Plasma; Platelet Activating Factor; Respiratory Physiological Phenomena; Respiratory System; Triazoles | 1990 |
Effects of a novel PAF antagonist, E6123, on PAF-induced biological responses.
Topics: Animals; Azepines; Blood Platelets; Bronchoconstriction; Bronchoconstrictor Agents; Dogs; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Platelet Activating Factor; Platelet Aggregation; Triazoles | 1990 |
Effects of a novel PAF antagonist, E6123, on passive anaphylaxis.
Topics: Anaphylaxis; Animals; Antigens; Azepines; Bronchoconstriction; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Platelet Activating Factor; Platelet Aggregation; Triazoles | 1990 |
Eosinophil accumulation in the rat pleural cavity after mast cell stimulation with compound 48/80 involves protein synthesis and is selectively suppressed by dexamethasone.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Azepines; Cycloheximide; Dexamethasone; Eosinophils; Female; Leukocyte Count; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Platelet Activating Factor; Pleura; Protein Biosynthesis; Rats; Rats, Inbred Strains; Triazoles | 1990 |
Pharmacological activities of a novel thienodiazepine derivative as a platelet-activating factor antagonist.
Topics: Administration, Oral; Animals; Azepines; Blood Platelets; Bronchoconstriction; Dogs; Guinea Pigs; Humans; In Vitro Techniques; Injections, Intravenous; Mice; Mice, Inbred ICR; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Species Specificity; Triazoles | 1990 |
Pharmacological actions of Y-24180: I. A potent and specific antagonist of platelet-activating factor.
Topics: Anaphylaxis; Animals; Azepines; Blood Pressure; Bronchi; Female; Guinea Pigs; Hematocrit; Male; Mice; Mice, Inbred ICR; Platelet Activating Factor; Rats; Rats, Inbred Lew; Triazoles | 1990 |
Platelet activating factor antagonists do not alter normal cerebral blood flow or cerebral oxygen consumption.
Topics: Animals; Azepines; Brain; Cerebrovascular Circulation; Diterpenes; Ginkgolides; Indomethacin; Lactones; Male; Oxygen Consumption; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles | 1990 |
Anaphylactic challenge causes eosinophil accumulation in bronchoalveolar lavage fluid of guinea pigs. Modulation by betamethasone, phenidone, indomethacin, WEB 2086, and a novel antiallergy agent, SCH 37224.
Topics: Albumins; Anaphylaxis; Animals; Asthma; Azepines; Betamethasone; Bronchoalveolar Lavage Fluid; Cell Count; Eosinophils; Guinea Pigs; Histamine; Immunization; Indomethacin; Leukotriene Antagonists; Lipoxygenase Inhibitors; Lung; Male; Naphthyridines; Ovalbumin; Platelet Activating Factor; Pyrazoles; Thromboxanes; Triazoles | 1990 |
Tumor necrosis factor (TNF) and endotoxin prime effects of PAF in vivo.
Topics: Animals; Azepines; Drug Interactions; Endotoxins; Gastrointestinal Transit; Mice; Platelet Activating Factor; Shock, Septic; Triazoles; Tumor Necrosis Factor-alpha | 1990 |
Effects of platelet activating factor antagonists on arachidonic acid-induced platelet aggregation and TXA2 formation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Azepines; Blood Platelets; Diterpenes; Ginkgolides; Imidazoles; In Vitro Techniques; Lactones; Naphthalenes; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Triazoles | 1990 |
Role of spermatozoal platelet-activating factor in fertilization.
Topics: Animals; Arachidonic Acids; Azepines; Chromatography, High Pressure Liquid; Female; Fertilization; Fertilization in Vitro; Humans; Leukotriene B4; Lipoxygenase; Male; Mice; Platelet Activating Factor; Pregnancy; Prostaglandins F; Sperm Motility; Spermatozoa; Thromboxane B2; Triazines; Triazoles | 1990 |
1,25-(OH)2 vitamin D-3 enhances Paf-stimulated calcium mobilization in U937 cells by expression of specific Paf binding sites.
Topics: Animals; Azepines; Calcitriol; Calcium; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Binding; Receptors, Cell Surface; Receptors, G-Protein-Coupled; SRS-A; Triazines; Triazoles | 1990 |
Platelet activating factor stimulates cyclo-oxygenase activity in guinea pig eosinophils. Concerted biosynthesis of thromboxane A2 and E-series prostaglandins.
Topics: Animals; Azepines; Calcimycin; Calcium; Complement C5a; Cyclooxygenase Inhibitors; Enzyme Activation; Eosinophils; Flurbiprofen; Guinea Pigs; Imidazoles; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Superoxides; Tetradecanoylphorbol Acetate; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Triazines; Triazoles | 1990 |
[Characterization of platelet-activating factor (PAF)-receptors in neutrophilic and eosinophilic granulocytes].
Topics: Azepines; Cell Degranulation; Eosinophils; Humans; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1990 |
Role of platelet-activating factor in ischemia/reperfusion-induced leukocyte adherence.
Topics: Animals; Azepines; Cats; Cell Adhesion; Diterpenes; Ginkgolides; Intestine, Small; Ischemia; Lactones; Leukocytes; Mesenteric Arteries; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reference Values; Reperfusion; Triazoles | 1990 |
Characterization of receptors for platelet-activating factor in guinea pig lung membranes.
Topics: Animals; Azepines; Cell Membrane; Female; Guinea Pigs; Kinetics; Lung; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles | 1990 |
Degree of platelet activating factor-induced neutrophil migration is dependent upon the molecular species.
Topics: Azepines; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; In Vitro Techniques; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Time Factors; Triazoles | 1990 |
[Protective effect of a platelet activating factor antagonist in experimental liver injury].
Topics: Animals; Azepines; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Liver; Malondialdehyde; Peroxidase; Platelet Activating Factor; Rats; Rats, Inbred Strains; Superoxide Dismutase; Triazoles | 1990 |
Effect of platelet-activating factor receptor antagonism on endotoxin-induced lung dysfunction in awake sheep.
Topics: Animals; Azepines; Consciousness; Cyclooxygenase Inhibitors; Endotoxins; Escherichia coli; Platelet Activating Factor; Platelet Membrane Glycoproteins; Premedication; Quinolinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Distress Syndrome; Sheep; Thromboxane-A Synthase; Triazoles | 1990 |
Influence of SK&F 95587 and BN 50730 on bronchoconstrictor responses in the cat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Azepines; Bronchoconstriction; Cats; Dose-Response Relationship, Drug; Female; Lung; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prostaglandin Endoperoxides, Synthetic; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Prostaglandin; Receptors, Thromboxane; Respiration; Sulfonamides; Tetrazoles; Thienopyridines; Time Factors; Triazoles | 1990 |
The relationship between neutrophils and increased microvascular permeability in a model of myocardial ischaemia and reperfusion in the rabbit.
Topics: Anesthesia; Animals; Antibodies, Monoclonal; Azepines; Blood Pressure; Blood Proteins; Capillary Permeability; Coronary Disease; Heart Rate; In Vitro Techniques; Indium Radioisotopes; Iodine Radioisotopes; Male; Mechlorethamine; Models, Biological; Myocardial Reperfusion Injury; Neutrophils; Platelet Activating Factor; Rabbits; Triazoles | 1990 |
Platelet activating factor (PAF) and tumor necrosis factor-alpha (TNF alpha) interactions in endotoxemic shock: studies with BN 50739, a novel PAF antagonist.
Topics: Animals; Azepines; Blood Cells; Hemodynamics; Humans; Lipopolysaccharides; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Strains; Recombinant Proteins; Shock, Septic; Thromboxanes; Triazoles; Tumor Necrosis Factor-alpha | 1990 |
Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits.
Topics: Animals; Azepines; Cerebrovascular Disorders; Disease Models, Animal; Platelet Activating Factor; Rabbits; Reference Values; Regional Blood Flow; Spinal Cord; Spinal Cord Injuries; Triazoles | 1990 |
A factor in serum lowers resistance and opens tight junctions of MDCK cells.
Topics: Animals; Azepines; Blood; Cell Line; Chromatography, Gel; Complement C3a; Complement C5a; Culture Media; Dogs; Humans; Inflammation; Intercellular Junctions; Kidney; Kinetics; Molecular Weight; Platelet Activating Factor; Serum Albumin; Triazoles | 1990 |
Use of WEB 2086 and WEB 2170 as platelet-activating factor antagonists.
Topics: Animals; Azepines; Blood Platelets; Humans; In Vitro Techniques; Lung; Methods; Molecular Structure; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Rabbits; Triazoles | 1990 |
Pulmonary hypertension after heparin-protamine: roles of left-sided infusion, histamine, and platelet-activating factor.
Topics: Animals; Azepines; Clemastine; Hemodynamics; Heparin Antagonists; Hypertension, Pulmonary; Platelet Activating Factor; Protamines; Ranitidine; Swine; Triazoles | 1990 |
IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators.
Topics: Acute Disease; Animals; Azepines; Bronchoconstriction; Dicarboxylic Acids; Dose-Response Relationship, Drug; Furans; Guinea Pigs; Immunization; Immunoglobulin G; Indoles; Lipids; Lung; Male; Ovalbumin; Phenylcarbamates; Piroxicam; Platelet Activating Factor; Propranolol; Pyrilamine; Respiratory Hypersensitivity; SRS-A; Sulfonamides; Tosyl Compounds; Triazoles | 1990 |
Phospholipase A2-induced pulmonary and hemodynamic responses in the guinea pig. Effects of enzyme inhibitors and mediators antagonists.
Topics: Animals; Azepines; Blood Pressure; Bronchi; Bronchoalveolar Lavage Fluid; Dexamethasone; Enzyme Inhibitors; Guinea Pigs; Humans; Indazoles; Indomethacin; Lung; Male; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Pressure; Propranolol; Pyrilamine; SRS-A; Trachea; Triazoles | 1990 |
Platelet-activating factor: evidence against a role in hypoxic pulmonary vasoconstriction.
Topics: Animals; Azepines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Injections, Intravenous; Male; Platelet Activating Factor; Pulmonary Circulation; Swine; Triazoles; Vascular Resistance; Vasoconstriction | 1990 |
Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Survival; Chloroquine; Diltiazem; Drug Synergism; Endocytosis; Furans; Humans; Hydroxyzine; In Vitro Techniques; Leukemia, Myeloid; Mice; Nifedipine; Phospholipid Ethers; Platelet Activating Factor; Pyridines; Quinidine; Quinine; Sodium Fluoride; Thiazoles; Triazoles; Verapamil | 1990 |
Contribution of platelet activating factor to hemodynamic and sympathetic responses to bacterial endotoxin in conscious rats.
Topics: Animals; Azepines; Blood Glucose; Blood Pressure; Catecholamines; Endotoxins; Heart Rate; Hemodynamics; Lactates; Lactic Acid; Male; Platelet Activating Factor; Rats; Shock, Septic; Sympathetic Nervous System; Triazoles | 1990 |
Alterations in endocardial vascular resistance after reperfusion in a low flow, high demand model of ischemia: effects of dipyridamole and WEB-2086, a platelet-activating factor antagonist.
Topics: Adenosine; Animals; Azepines; Coronary Vessels; Dipyridamole; Dogs; Hemodynamics; Myocardial Reperfusion Injury; Platelet Activating Factor; Triazoles; Vascular Resistance | 1990 |
Intrapulmonary tumor necrosis factor triggers local platelet-activating factor production in rat immune complex alveolitis.
Topics: Alveolitis, Extrinsic Allergic; Animals; Antibodies; Antigen-Antibody Complex; Azepines; Furans; Immunoglobulin G; Kinetics; Lung; Macrophages; Male; Neutrophils; Platelet Activating Factor; Rats; Triazoles; Tumor Necrosis Factor-alpha | 1990 |
Pharmacologic activity of bepafant (WEB 2170), a new and selective hetrazepinoic antagonist of platelet activating factor.
Topics: Administration, Oral; Animals; Azepines; Bronchoconstriction; Capillary Permeability; Cell Aggregation; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Hypotension; Infusions, Intravenous; Injections, Intradermal; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Strains; Skin; Time Factors; Triazoles | 1990 |
Alterations in regional blood flow in rats following sensitization to the nematode Nippostrongylus brasiliensis: effects of PAF antagonists.
Topics: Animals; Anthelmintics; Azepines; Blood Pressure; Cardiac Output; Diterpenes; Ginkgolides; Heart Rate; Immunization; Injections, Intraperitoneal; Lactones; Liver Circulation; Male; Microspheres; Nippostrongylus; Platelet Activating Factor; Rats; Rats, Inbred Strains; Regional Blood Flow; Submandibular Gland; Triazoles; Vascular Resistance | 1990 |
Antagonism of endotoxin-induced disruption of equine gastrointestinal motility with the platelet-activating factor antagonist WEB 2086.
Topics: Animals; Azepines; Endotoxins; Gastrointestinal Motility; Heart Rate; Hematocrit; Horses; Leukocyte Count; Male; Muscle Contraction; Platelet Activating Factor; Stomach; Triazoles | 1990 |
Relaxations of guinea-pig isolated trachea induced by platelet-activating factor are epithelial-dependent and are antagonised by WEB 2086.
Topics: Albuterol; Animals; Azepines; Epithelium; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth; Platelet Activating Factor; Trachea; Triazoles | 1990 |
Beneficial effect of a platelet-activating factor antagonist, WEB 2086, on endotoxin-induced lung injury.
Topics: Animals; Azepines; Dose-Response Relationship, Drug; Endotoxins; Glutathione; Glutathione Disulfide; In Vitro Techniques; Lung; Male; Permeability; Platelet Activating Factor; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Time Factors; Triazines; Triazoles | 1990 |
Endogenous platelet activating factor does not modulate blood flow and metabolism in normal rat brain.
Topics: Animals; Azepines; Blood Pressure; Brain; Cerebrovascular Circulation; Diterpenes; Ginkgolides; Indomethacin; Lactones; Male; Oxygen; Platelet Activating Factor; Rats; Rats, Inbred Strains; Reference Values; Triazines; Triazoles | 1990 |
The action of platelet activating factor and its antagonism by WEB 2086 on human isolated airways.
Topics: Azepines; Bronchi; Histamine; Humans; Muscle Contraction; Muscle, Smooth; Platelet Activating Factor; Triazines; Triazoles | 1990 |
Failure of platelet-activating factor (PAF-acether) to induce decidualization in mice and failure of antagonists of PAF to inhibit implantation.
Topics: Animals; Azepines; Decidua; Diterpenes; Embryo Implantation; Estradiol; Female; Ginkgolides; Lactones; Mice; Mice, Inbred Strains; Ovariectomy; Phospholipid Ethers; Platelet Activating Factor; Pregnancy; Progesterone; Triazines; Triazoles | 1990 |
The effects of activated eosinophils and neutrophils on guinea pig airway epithelium in vitro.
Topics: Animals; Azepines; Catalase; Cell Survival; Cilia; Eosinophils; Epithelium; Guinea Pigs; Male; Neutrophils; Peritoneal Cavity; Platelet Activating Factor; Trachea; Triazines; Triazoles | 1990 |
Platelet activating factor and sheep platelets: a sensitive new bioassay.
Topics: Adenosine Diphosphate; Alprazolam; Animals; Azepines; Biological Assay; Blood Platelets; Cell Separation; Furans; Platelet Activating Factor; Platelet Aggregation; Serotonin; Sheep; Thrombin; Triazines; Triazoles | 1990 |
Prevention of non-specific airway hyperreactivity after allergen challenge in guinea-pigs by the PAF receptor antagonist SDZ 64-412.
Topics: Allergens; Animals; Azepines; Bronchi; Bronchoalveolar Lavage Fluid; Eosinophils; Guinea Pigs; Histamine; Hypersensitivity; In Vitro Techniques; Isoquinolines; Male; Methylprednisolone; Platelet Activating Factor; Triazines; Triazoles; Vagotomy; Vagus Nerve | 1990 |
Differential inhibition by two hetrazepine PAF antagonists of acute inflammation in the mouse.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Carrageenan; Dose-Response Relationship, Drug; Edema; Exudates and Transudates; Female; Leukocyte Count; Male; Mice; Platelet Activating Factor; Pleurisy; Serotonin; Triazines; Triazoles | 1990 |
Inhibition of neutrophil and eosinophil chemotactic responses to PAF by the PAF-antagonists WEB-2086, L-652,731, and SRI-63441.
Topics: Azepines; Chemotaxis; Complement C5; Eosinophils; Furans; Humans; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Quinolinium Compounds; Triazoles | 1990 |
PAF potentiates protamine-induced lung edema: role of pulmonary venoconstriction.
Topics: Animals; Azepines; Drug Synergism; In Vitro Techniques; Male; Neutrophils; Platelet Activating Factor; Protamines; Pulmonary Circulation; Pulmonary Edema; Rats; Rats, Inbred Strains; Triazoles; Vasoconstriction | 1990 |
Platelet activating factor and one-kidney, one clip hypertension.
Topics: Animals; Azepines; Blood Platelets; Blood Pressure; Hypertension, Renal; Male; Platelet Activating Factor; Rats; Rats, Inbred Strains; Renal Artery; Serotonin; Sodium; Triazoles | 1990 |
Pharmacologic profile of BN 50739, a new PAF antagonist in vitro and in vivo.
Topics: Animals; Azepines; Blood Platelets; Hypotension; In Vitro Techniques; Male; Platelet Activating Factor; Rabbits; Rats; Rats, Inbred Strains; Serotonin; Triazoles | 1990 |
Activation of human platelets by C5a-stimulated neutrophils: a role for cathepsin G.
Topics: Amino Acid Sequence; Aspirin; Azepines; Blood Platelets; Cathepsin G; Cathepsins; Complement C5a; Humans; In Vitro Techniques; Kinetics; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Pancreatic Elastase; Platelet Activating Factor; Platelet Activation; Protease Inhibitors; Recombinant Proteins; Serine Endopeptidases; Serotonin; Triazoles | 1990 |
Search for mediators of the lipogenic effects of tumor necrosis factor: potential role for interleukin 6.
Topics: Animals; Aspirin; Azepines; Cholesterol; Fatty Acids; Ibuprofen; Interleukin-6; Lipids; Liver; Male; Mice; Mice, Inbred C57BL; Oleic Acid; Oleic Acids; Pentoxifylline; Phenoxybenzamine; Platelet Activating Factor; Propranolol; Rats; Rats, Inbred Strains; Reference Values; Triazoles; Triglycerides; Tumor Necrosis Factor-alpha | 1990 |
Platelet-activating factor and progressive brain damage following focal brain injury.
Topics: Animals; Azepines; Blood-Brain Barrier; Body Water; Brain Injuries; Cerebral Cortex; Male; Neurons; Neutrophils; Permeability; Platelet Activating Factor; Rats; Rats, Inbred Strains; Regional Blood Flow; Triazoles | 1990 |
Early and late tracheobronchial plasma exudation by platelet-activating factor administered to the airway mucosal surface in guinea pigs: effects of WEB 2086 and enprofylline.
Topics: Animals; Azepines; Bronchi; Capillary Permeability; Guinea Pigs; Male; Mucous Membrane; Platelet Activating Factor; Trachea; Triazoles; Xanthines | 1990 |
Platelet-activating factor mediates gastric damage induced by hemorrhagic shock.
Topics: Animals; Azepines; Diterpenes; Gastric Mucosa; Ginkgolides; Lactones; Male; Membrane Potentials; Muscle, Smooth; Platelet Activating Factor; Rats; Rats, Inbred Strains; Regional Blood Flow; Shock, Hemorrhagic; Stomach; Triazoles | 1990 |
The booster injection of antigen during active sensitization of guinea-pig modifies the anti-anaphylactic activity of the PAF antagonist WEB 2086.
Topics: Anaphylaxis; Animals; Azepines; Blood Cell Count; Bronchi; Enzyme-Linked Immunosorbent Assay; Guinea Pigs; Histamine; Immunization, Secondary; Immunoglobulin G; Lung; Ovalbumin; Platelet Activating Factor; Radioimmunoassay; Spectrometry, Fluorescence; Thromboxane B2; Triazoles | 1990 |
Effects of the PAF antagonist WEB 2086 on PAF-induced physiologic alterations and on IgE anaphylaxis in the rabbit.
Topics: Anaphylaxis; Animals; Azepines; Bronchial Spasm; Hypotension; Immunoglobulin E; Leukopenia; Lung; Platelet Activating Factor; Rabbits; Thrombocytopenia; Triazoles | 1990 |
Failure of the platelet-activating-factor antagonist WEB 2086 BS for treatment of chronic autoimmune thrombocytopenia.
Topics: Adult; Aged; Autoimmune Diseases; Azepines; Chronic Disease; Drug Evaluation; Female; Humans; Male; Middle Aged; Platelet Activating Factor; Prospective Studies; Thrombocytopenia; Triazoles | 1990 |
Prolongation of rat heart allograft survival using low-dose cyclosporine and PAF antagonist WEB 2170.
Topics: Animals; Azepines; Cyclosporins; Graft Rejection; Graft Survival; Heart Transplantation; Platelet Activating Factor; Rats; Transplantation, Heterotopic; Transplantation, Homologous; Triazoles | 1990 |
Effects of a PAF-antagonist (WEB 2086) on hyperacute xenogeneic rejection in ex vivo perfused kidneys.
Topics: Animals; Azepines; Female; Graft Rejection; Hemagglutination Tests; Humans; Kidney Transplantation; Male; Perfusion; Platelet Activating Factor; Swine; Transplantation, Heterologous; Triazoles | 1990 |
Hypoxia causes ischemic bowel necrosis in rats: the role of platelet-activating factor (PAF-acether).
Topics: Animals; Azepines; Enterocolitis, Pseudomembranous; Hypoxia; Intestine, Small; Male; Platelet Activating Factor; Quinolinium Compounds; Rats; Rats, Inbred Strains; Triazoles | 1990 |
Protective effect of BN 50739, a new platelet-activating factor antagonist, in endotoxin-treated rabbits.
Topics: Animals; Azepines; Blood Cell Count; Endotoxins; Leukopenia; Male; Platelet Activating Factor; Rabbits; Thrombocytopenia; Thromboxane B2; Triazoles | 1990 |
Biological responses to liposome-encapsulated hemoglobin (LEH) are improved by a PAF antagonist.
Topics: Animals; Azepines; Blood Substitutes; Chemical Phenomena; Chemistry, Physical; Drug Interactions; Hemodynamics; Hemoglobins; Leukocyte Count; Liposomes; Male; Oxygen; Phosphatidylcholines; Platelet Activating Factor; Platelet Count; Rats; Rats, Inbred Strains; Thromboxane B2; Triazoles | 1990 |
Limited interference of specific Paf antagonists with hyper-responsiveness to Paf itself of lungs from actively sensitized guinea-pigs.
Topics: Animals; Azepines; Bronchi; Female; Guinea Pigs; Histamine; Histamine Release; Hypersensitivity; In Vitro Techniques; Lung; Male; Muscle, Smooth; Perfusion; Platelet Activating Factor; Pulmonary Edema; SRS-A; Trachea; Triazines; Triazoles | 1989 |
Evidence for an intracellular action of platelet-activating factor in bovine cultured aortic endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Thoracic; Azepines; Bradykinin; Calcimycin; Cattle; Cells, Cultured; Endothelium, Vascular; Platelet Activating Factor; Triazines; Triazoles | 1989 |
Interactions of platelet activating factor, thromboxane A2 and leukotrienes in guinea-pig heart.
Topics: Anaphylaxis; Animals; Azepines; Cyclooxygenase Inhibitors; Guinea Pigs; Heart; In Vitro Techniques; Indomethacin; Leukotrienes; Lipoxygenase Inhibitors; Naphthoquinones; ortho-Aminobenzoates; Platelet Activating Factor; Thromboxane A2; Triazines; Triazoles | 1989 |
Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086. Correlation between receptor binding and function.
Topics: Azepines; Glucuronidase; Humans; In Vitro Techniques; Kinetics; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazines; Triazoles | 1989 |
Structure-activity relationships and effects of platelet-activating factor antagonists in the hetrazepine series.
Topics: Azepines; Computer Simulation; Drug Design; Humans; In Vitro Techniques; Models, Molecular; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazines; Triazoles | 1989 |
The benzodiazepine receptor ligands RO 5-4864 and RO 15-1788 do not block the inhibition of PAF-induced platelet aggregation seen with the hetrazepine WEB2086.
Topics: Adenosine Triphosphate; Animals; Azepines; Benzodiazepinones; Blood Platelets; Female; Flumazenil; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, GABA-A; Triazines; Triazoles | 1989 |
Stimulation of degranulation from human eosinophils by platelet-activating factor.
Topics: Alkaline Phosphatase; Azepines; Calcium; Cytoplasmic Granules; Eosinophil Peroxidase; Eosinophils; Extracellular Space; Glucuronidase; Humans; Kinetics; Peroxidases; Platelet Activating Factor; Superoxides; Triazines; Triazoles | 1989 |
PAF-receptors on eosinophils: identification with a novel ligand, [3H]WEB 2086.
Topics: Animals; Azepines; Eosinophils; Guinea Pigs; Peroxidases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazines; Triazoles | 1989 |
Presence of specific platelet-activating factor binding sites in the rat retina.
Topics: Animals; Azepines; Diterpenes; Ginkgolides; In Vitro Techniques; Lactones; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Retina; Triazines; Triazoles | 1989 |
Evidence for two platelet activating factor receptors on eosinophils: dissociation between PAF-induced intracellular calcium mobilization degranulation and superoxides anion generation in eosinophils.
Topics: Animals; Azepines; Calcium; Eosinophil Peroxidase; Eosinophils; Guinea Pigs; Magnesium; Male; Peroxidases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Superoxides; Triazines; Triazoles | 1989 |
Intracellular platelet-activating factor regulates eicosanoid generation in guinea-pig resident peritoneal macrophages.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Azepines; Calcimycin; Chromatography, High Pressure Liquid; Culture Media; Dinoprostone; Eicosanoids; Guinea Pigs; In Vitro Techniques; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Peritoneal Cavity; Platelet Activating Factor; Superoxides; Triazines; Triazoles | 1989 |
[3H]WEB 2086 labels platelet activating factor receptors in guinea pig and human lung.
Topics: Animals; Azepines; Guinea Pigs; In Vitro Techniques; Lung; Male; Membranes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazines; Triazoles | 1989 |
Interaction of the Paf antagonist WEB 2086 and its hetrazepine analogues with human platelets and endothelial cells.
Topics: Azepines; Blood Platelets; Calcium; Cytosol; Endothelium, Vascular; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazines; Triazoles; Umbilical Veins | 1989 |
PAF-acether-induced mortality in mice: protection by benzodiazepines.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Benzodiazepines; Cattle; Death; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mice; Plant Extracts; Platelet Activating Factor; Pyrilamine; Triazoles | 1989 |
Effects of platelet-activating factor on ion transport in isolated rat jejunum.
Topics: Animals; Azepines; Biological Transport; Diterpenes; Electric Conductivity; Ginkgolides; In Vitro Techniques; Ions; Jejunum; Lactones; Male; Mast Cells; Platelet Activating Factor; Rats; Rats, Inbred Strains; Thioxanthenes; Triazines; Triazoles; Xanthones | 1989 |
Platelet-activating factor (PAF) acts as an intercellular messenger in the changes of cytosolic free Ca2+ in human neutrophils induced by opsonized particles.
Topics: Azepines; Calcium; Cytosol; Humans; In Vitro Techniques; Neutrophils; Phagocytosis; Platelet Activating Factor; Signal Transduction; Triazines; Triazoles; Zymosan | 1989 |
Chemotactic effect of PAF-acether on peritoneal eosinophils from normal rats.
Topics: Animals; Azepines; Chemotactic Factors; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Diterpenes; Eosinophils; Ginkgolides; In Vitro Techniques; Lactones; Male; Peritoneal Cavity; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles | 1989 |
The pathophysiological role of PAF in anaphylactic lung reaction in the guinea pig and in endotoxin shock evidenced by the specific PAF-antagonist WEB 2086.
Topics: Anaphylaxis; Animals; Antigens; Azepines; Disease Models, Animal; Endotoxins; Escherichia coli; Guinea Pigs; Lung Diseases; Ovalbumin; Platelet Activating Factor; Pyrilamine; Shock, Septic; Triazines; Triazoles | 1989 |
Endothelin-induced sudden death and the possible involvement of platelet activating factor (PAF).
Topics: Animals; Aspirin; Azepines; Blood Pressure; Death, Sudden; Dexamethasone; Diltiazem; Electrocardiography; Endothelins; Guinea Pigs; Hypertension; Hypotension; Male; Mice; Mice, Inbred ICR; Peptides; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Inbred Strains; Triazines; Triazoles | 1989 |
Protective effects of a specific platelet activating factor (PAF) antagonist, WEB 2086, in traumatic shock.
Topics: Animals; Azepines; Blood Pressure; Cathepsin D; Male; Mice; Myocardial Depressant Factor; Nitrogen; Platelet Activating Factor; Rats; Rats, Inbred Strains; Shock, Traumatic; Triazines; Triazoles | 1989 |
A possible role for PAF in allergen-induced late responses: modification by a selective antagonist.
Topics: Aerosols; Allergens; Animals; Antigens, Helminth; Ascaris; Asthma; Azepines; Chlorpheniramine; Chromones; Disease Models, Animal; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Indomethacin; Lung; Platelet Activating Factor; Reference Values; Sheep; SRS-A; Triazines; Triazoles | 1989 |
PAF-induced platelet aggregation ex vivo as a method for monitoring pharmacological activity in healthy volunteers.
Topics: Adult; Azepines; Blood Pressure; Double-Blind Method; Electrocardiography; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Random Allocation; Triazines; Triazoles | 1989 |
Platelet aggregation in whole blood: is the response to adrenaline, 5-hydroxytryptamine and PAF a direct consequence of stimulation by these agonists?
Topics: Apyrase; Azepines; Cell Count; Dioxanes; Dose-Response Relationship, Drug; Epinephrine; Hirudins; Humans; Idazoxan; Indomethacin; Ketanserin; Platelet Activating Factor; Platelet Aggregation; Serotonin; Triazines; Triazoles | 1989 |
Interference of WEB 2086 and BN 52021 with Paf-induced effects on guinea-pig trachea.
Topics: Animals; Azepines; Dinoprostone; Diterpenes; Ginkgolides; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Lactones; Male; Muscle Relaxation; Muscle, Smooth; Platelet Activating Factor; Trachea; Triazines; Triazoles | 1989 |
Platelet-activating factor (Paf) antagonist, WEB 2086, protects against Paf-induced hypotension in Macaca fascicularis.
Topics: Animals; Azepines; Blood Pressure; Dose-Response Relationship, Drug; Histamine; Macaca fascicularis; Male; Platelet Activating Factor; Triazines; Triazoles | 1989 |
The effect of Paf antagonists on bronchial hyperresponsiveness induced by Paf, propranolol or indomethacin.
Topics: Acetylcholine; Animals; Azepines; Bronchi; Diterpenes; Ginkgolides; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Lactones; Male; Phospholipid Ethers; Platelet Activating Factor; Propranolol; Respiratory Hypersensitivity; Triazines; Triazoles | 1989 |
A PAF antagonist blocks antigen-induced airway hyperresponsiveness and inflammation in sheep.
Topics: Airway Resistance; Animals; Antigens, Helminth; Ascaris; Azepines; Bronchoalveolar Lavage Fluid; Carbachol; Dose-Response Relationship, Drug; Platelet Activating Factor; Respiratory Hypersensitivity; Sheep; Triazines; Triazoles | 1989 |
Effect of a new and specific PAF-antagonist, WEB 2086, on PAF and endotoxin/tumor necrosis factor induced changes in mortality and intestinal transit velocity.
Topics: Animals; Azepines; Drug Synergism; Endotoxins; Gastrointestinal Motility; Mice; Platelet Activating Factor; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 1989 |
Effect of PAF-antagonists in endotoxin shock--ovine and rat experiments.
Topics: Animals; Azepines; Blood Pressure; Diterpenes; Ginkgolides; Hemodynamics; Kinetics; Lactones; Lymph; Male; Platelet Activating Factor; Proteins; Pulmonary Artery; Rats; Rats, Inbred Strains; Sheep; Shock, Septic; Triazines; Triazoles | 1989 |
Platelet-activating factor induces the production of leukotrienes by human monocytes.
Topics: Azepines; Cells, Cultured; Chromatography, High Pressure Liquid; Diterpenes; Ginkgolides; Humans; Kinetics; Lactones; Leukotrienes; Monocytes; Plant Extracts; Platelet Activating Factor; Triazines; Triazoles | 1989 |
The relevance of eicosanoids including PAF for the biochemical regulation of cardiac rhythm.
Topics: Alprostadil; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Azepines; Diterpenes; Dogs; Fatty Acids, Unsaturated; Female; Ginkgolides; Guinea Pigs; Heart Rate; In Vitro Techniques; Lactones; Male; Platelet Activating Factor; Sulfonamides; Triazines; Triazoles | 1989 |
Effect of platelet-activating factor (PAF) on porcine pulmonary vessels in vitro.
Topics: Animals; Azepines; In Vitro Techniques; Leukotrienes; Platelet Activating Factor; Pulmonary Artery; Pulmonary Veins; Swine; Triazines; Triazoles; Vasoconstriction | 1989 |
Tumor necrosis factor-induced lung injury is not mediated by platelet-activating factor.
Topics: Animals; Azepines; Capillary Permeability; Eicosanoids; Glutathione; Lung; Male; Platelet Activating Factor; Pulmonary Circulation; Rats; Rats, Inbred Strains; Surface Properties; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 1989 |
Evidence against a role for platelet-activating factor in hypoxic pulmonary vasoconstriction in the rat.
Topics: Animals; Azepines; Diterpenes; Ginkgolides; Hypoxia; Lactones; Male; Platelet Activating Factor; Pulmonary Circulation; Rats; Rats, Inbred Strains; Triazines; Triazoles; Vasoconstriction | 1989 |
Density heterogeneity of eosinophil leucocytes: induction of hypodense eosinophils by platelet-activating factor.
Topics: Animals; Azepines; Centrifugation, Density Gradient; Eosinophils; Guinea Pigs; Platelet Activating Factor; Triazines; Triazoles | 1989 |
Characterization of receptors for platelet-activating factor on platelets, polymorphonuclear leukocytes and macrophages.
Topics: Animals; Azepines; Blood Platelets; Calcimycin; Cell Aggregation; Diterpenes; Epoprostenol; Furans; Ginkgolides; In Vitro Techniques; Lactones; Macrophages; Male; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazines; Triazoles | 1988 |
Idiopathic thrombocytopenia treated with Paf-acether antagonist WEB 2086.
Topics: Administration, Oral; Azepines; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Count; Thrombocytopenia; Triazines; Triazoles | 1988 |
Characterization of platelet-activating factor-induced elevation of cytosolic free calcium concentration in eosinophils.
Topics: Animals; Azepines; Calcium; Cytosol; Eosinophils; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Platelet Activating Factor; Reference Values; Triazines; Triazoles | 1989 |
Pharmacological modulation of Paf-induced rat pleurisy and its role in inflammation by zymosan.
Topics: Animals; Azepines; Carrageenan; Leukocyte Count; Male; Platelet Activating Factor; Pleurisy; Pyridines; Rats; Rats, Inbred Strains; Thiazoles; Triazines; Triazoles; Zymosan | 1989 |
Platelet-activating factor-induced contraction of guinea-pig lung parenchymal strips: possible involvement of arachidonate metabolites.
Topics: Acetylcholine; Animals; Arachidonic Acids; Atropine; Azepines; Cyclooxygenase Inhibitors; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Lipoxygenase Inhibitors; Lung; Male; Muscle Contraction; Muscle, Smooth; Platelet Activating Factor; Thromboxane A2; Triazines; Triazoles | 1988 |
PAF-acether and endotoxin display similar effects on rat mesenteric microvessels: inhibition by specific antagonists.
Topics: Animals; Azepines; Blood Pressure; Diterpenes; Endotoxins; Ginkgolides; Lactones; Male; Microcirculation; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rats; Rats, Inbred Strains; Splanchnic Circulation; Triazines; Triazoles | 1988 |
Inhibitory effect of oral WEB 2086, a novel selective PAF-acether antagonist, on ex vivo platelet aggregation.
Topics: Adult; Azepines; Double-Blind Method; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Random Allocation; Triazines; Triazoles | 1988 |
The thieno-triazolodiazepine WEB 2086 inhibits platelet aggregation and ATP release from porcine platelets induced by platelet activating factor (PAF).
Topics: Adenosine Triphosphate; Animals; Azepines; Blood Platelets; Platelet Activating Factor; Platelet Aggregation Inhibitors; Swine; Triazines; Triazoles | 1988 |
Effect of the PAF-antagonist WEB 2086 on anaphylactic lung reaction: comparison of inhalative and intravenous challenge.
Topics: Administration, Inhalation; Anaphylaxis; Animals; Azepines; Blood Pressure; Guinea Pigs; Injections, Intravenous; Lung; Platelet Activating Factor; Triazines; Triazoles | 1988 |
Radioligand binding of antagonists of platelet-activating factor to intact human platelets.
Topics: Azepines; Binding Sites; Binding, Competitive; Blood Platelets; Humans; Kinetics; Platelet Activating Factor; Pyridines; Thiazoles; Triazines; Triazoles; Tritium | 1988 |
Effect of a Paf antagonist, WEB 2086, on airway microvascular leakage in the guinea-pig and platelet aggregation in man.
Topics: Adenosine Diphosphate; Animals; Azepines; Capillary Permeability; Guinea Pigs; Humans; In Vitro Techniques; Male; Ovalbumin; Platelet Activating Factor; Platelet Aggregation; Triazines; Triazoles | 1988 |
Platelet-activating factor induces eosinophil peroxidase release from purified human eosinophils.
Topics: Azepines; Eosinophil Peroxidase; Eosinophils; Humans; Peroxidases; Platelet Activating Factor; Triazines; Triazoles | 1988 |
Platelet-activating factor (PAF-acether) and microcirculation: effect of Lyso-PAF and PAF-antagonists.
Topics: Animals; Azepines; Male; Mesenteric Arteries; Microcirculation; Norepinephrine; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazines; Triazoles; Vasoconstriction | 1987 |
Protective effect of WEB 2086, a novel antagonist of platelet activating factor, in endotoxin shock.
Topics: Animals; Azepines; Blood Pressure; Male; Platelet Activating Factor; Rats; Rats, Inbred Strains; Shock, Septic; Triazines; Triazoles | 1987 |
WEB 2086. A potent PAF antagonist exerts protective effect toward PAF-induced gastric damage.
Topics: Animals; Azepines; Gastric Mucosa; Platelet Activating Factor; Rats; Stomach Ulcer; Triazines; Triazoles | 1987 |
Effects of WEB 2086, a novel antagonist of platelet activating factor, in active and passive anaphylaxis.
Topics: Administration, Oral; Anaphylaxis; Animals; Azepines; Blood Pressure; Guinea Pigs; Immunization; Immunization, Passive; Injections, Intravenous; Male; Mice; Ovalbumin; Platelet Activating Factor; Pyrilamine; Respiration; Triazines; Triazoles | 1987 |
Pharmacological actions of WEB 2086, a new specific antagonist of platelet activating factor.
Topics: Animals; Anticonvulsants; Azepines; Capillary Permeability; Chemical Phenomena; Chemistry; Guinea Pigs; Humans; Hypnotics and Sedatives; Indium; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Skin; Triazines; Triazoles | 1987 |
Interference by the novel PAF-acether antagonist WEB 2086 with the bronchopulmonary responses to PAF-acether and to active and passive anaphylactic shock in guinea-pigs.
Topics: Anaphylaxis; Animals; Azepines; Female; Guinea Pigs; Histamine; In Vitro Techniques; Indicators and Reagents; Leukopenia; Male; Passive Cutaneous Anaphylaxis; Platelet Activating Factor; Radioimmunoassay; Respiratory System; Spectrometry, Fluorescence; Thrombocytopenia; Thromboxane B2; Triazines; Triazoles | 1987 |
Bronchial and vascular effects of Paf in the rat isolated lung are completely blocked by WEB 2086, a novel specific Paf antagonist.
Topics: Animals; Azepines; Blood Pressure; Bronchi; Female; In Vitro Techniques; Lung; Organ Size; Platelet Activating Factor; Pulmonary Artery; Rats; Rats, Inbred Strains; Triazines; Triazoles | 1987 |
PAF antagonistic activity of some thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines.
Topics: Azepines; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Aggregation; Thiophenes; Triazoles | 1987 |
Effects of platelet-activating factor antagonists WEB 2086 and BN 50730 on digoxin-induced arrhythmias.
Topics: Animals; Arrhythmias, Cardiac; Azepines; Digoxin; Female; Guinea Pigs; Hemodynamics; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Thienopyridines; Triazoles | 1995 |
Effect of a platelet-activating factor antagonist on pancreas perfusion after 24 h of ischemia.
Topics: Animals; Azepines; Cold Temperature; Ischemia; Pancreas; Platelet Activating Factor; Reperfusion; Swine; Tissue Preservation; Triazoles | 1995 |
PAF effects on eicosanoid release in neonatal rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Aspirin; Azepines; Cyclooxygenase Inhibitors; Epoprostenol; Heart; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thromboxane A2; Triazoles | 1995 |
Beneficial effect of the platelet-activating factor antagonist WEB 2170 on reperfusion injury after orthotopic liver transplantation.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azepines; Bilirubin; Body Weight; Graft Survival; Liver; Liver Function Tests; Liver Transplantation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Reperfusion Injury; Swine; Time Factors; Triazoles | 1995 |
Tumor necrosis factor alpha-induced angiogenesis depends on in situ platelet-activating factor biosynthesis.
Topics: Animals; Azepines; Collagen; Drug Combinations; Female; Laminin; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Platelet Activating Factor; Proteoglycans; Triazoles; Tumor Necrosis Factor-alpha | 1994 |
Effect of platelet-activating factor and its antagonists on colonic dysmotility and tissue levels of colonic neuropeptides.
Topics: Alprazolam; Animals; Azepines; Colitis; Colon; Gastrointestinal Motility; In Vitro Techniques; Iodine Radioisotopes; Neuropeptides; Platelet Activating Factor; Rabbits; Substance P; Triazoles; Vasoactive Intestinal Peptide | 1994 |
Nitric oxide synthase inhibitors 7- and 6-nitroindazole relax smooth muscle in vitro.
Topics: Alprazolam; Animals; Azepines; Colitis; Colon; Gastrointestinal Motility; In Vitro Techniques; Iodine Radioisotopes; Neuropeptides; Platelet Activating Factor; Rabbits; Substance P; Triazoles; Vasoactive Intestinal Peptide | 1994 |
Potentiation of histamine release from human leucocytes by PAF.
Topics: Adolescent; Adult; Antibodies, Anti-Idiotypic; Azepines; Chemotactic Factors; Dipeptides; Female; Granulocytes; Histamine Release; Humans; Hypersensitivity, Immediate; Immunoglobulin E; In Vitro Techniques; Leukocytes; Male; Platelet Activating Factor; Triazoles | 1994 |
Platelet-activating factor-induced endothelial cell expression of adhesion molecules and modulation of surface glycocalyx, evaluated by electron spectroscopy chemical analysis.
Topics: Antibodies, Monoclonal; Azepines; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cycloheximide; Electron Probe Microanalysis; Endothelium, Vascular; Fluorescent Antibody Technique; Gene Expression Regulation; Glycoproteins; Humans; Neutrophils; P-Selectin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polysaccharides; Proteoglycans; Triazoles; Umbilical Veins | 1994 |
The vitronectin receptor (alpha v beta 3) is implicated, in cooperation with P-selectin and platelet-activating factor, in the adhesion of monocytes to activated endothelial cells.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Azepines; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Humans; Integrins; Molecular Sequence Data; Monocytes; Oligopeptides; P-Selectin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cytoadhesin; Receptors, Vitronectin; Thrombin; Triazoles; Umbilical Veins | 1994 |
Effect of PAF antagonists on cerulein-induced pancreatitis.
Topics: Acute Disease; Amylases; Animals; Azepines; Capillary Permeability; Ceruletide; Diterpenes; Evans Blue; Ginkgolides; Lactones; Male; Pancreas; Pancreatitis; Platelet Activating Factor; Rats; Rats, Wistar; Triazoles | 1995 |
Effects of stroma-free hemoglobin solutions on pulmonary vascular resistance and mediator release in the isolated perfused rabbit lung.
Topics: Animals; Azepines; Catalase; Cattle; Deferoxamine; Diclofenac; Female; Free Radical Scavengers; Hemoglobins; Histamine Release; Iron; Male; Perfusion; Platelet Activating Factor; Pulmonary Circulation; Rabbits; Stimulation, Chemical; Thromboxane B2; Triazoles; Vascular Resistance; Vasoconstriction | 1994 |
Mechanisms of oxidized chylomicron-induced leukocyte-endothelial cell adhesion.
Topics: Animals; Antibodies, Monoclonal; Azepines; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Chylomicrons; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Leukocytes; Lipid Peroxidation; Male; Microcirculation; Oxidation-Reduction; P-Selectin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Splanchnic Circulation; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Triazoles | 1995 |
Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis.
Topics: Aged; Animals; Azepines; Base Sequence; Cell Line; Chemotaxis; Choriocarcinoma; Collagen; Culture Media, Conditioned; Cytokines; Dogs; Drug Combinations; Endothelium, Vascular; Female; Growth Substances; Humans; Interleukin-1; Laminin; Lymphoma, Large B-Cell, Diffuse; Macrophages; Male; Mice; Mice, Inbred DBA; Molecular Sequence Data; Neoplasm Proteins; Neovascularization, Pathologic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteoglycans; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sarcoma, Kaposi; Skin Neoplasms; Thrombin; Triazoles; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Umbilical Veins; Uterine Neoplasms | 1995 |
Platelet-activating factor mediated potentiation of stimulation-evoked catecholamine release and the rise in intracellular free Ca2+ concentration in adrenal chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Adrenal Glands; Animals; Azepines; Caffeine; Calcium; Catecholamines; Cattle; Cells, Cultured; Chromaffin Granules; Dose-Response Relationship, Drug; Kinetics; Platelet Activating Factor; Platelet Membrane Glycoproteins; Potassium Chloride; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Stimulation, Chemical; Time Factors; Triazoles | 1995 |
Nitric oxide inhibition does not prevent the hypotensive response to increased renal perfusion in rabbits.
Topics: Animals; Arginine; Azepines; Blood Pressure; Diuresis; Enzyme Inhibitors; Extracorporeal Circulation; Female; Kidney; Male; Natriuresis; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Perfusion; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Renal Circulation; Sodium Bicarbonate; Triazoles; Vascular Resistance | 1995 |
[The effect of platelet-activating factor antagonists on early bacteria translocation of rat after burn injury].
Topics: Animals; Azepines; Bacterial Translocation; Burns; Escherichia coli; Escherichia coli Infections; Platelet Activating Factor; Random Allocation; Rats; Rats, Wistar; Triazoles | 1995 |
Platelet-activating factor stimulates gastric acid secretion in isolated rabbit gastric glands.
Topics: Aminopyrine; Animals; Azepines; Biological Transport; Calcium; Carbachol; Dose-Response Relationship, Drug; Egtazic Acid; Famotidine; Fluorescent Dyes; Gastric Acid; Gastric Mucosa; Histamine; In Vitro Techniques; Kinetics; Male; Platelet Activating Factor; Rabbits; Thiazoles; Thienopyridines; Triazoles; Verapamil | 1995 |
Biosynthesis of platelet-activating factor in normal and inflamed human colon mucosa: evidence for the involvement of the pathway of platelet-activating factor synthesis de novo in inflammatory bowel disease.
Topics: Aged; Azepines; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Colon; Culture Techniques; Cytidine Diphosphate Choline; Female; Glyceryl Ethers; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Middle Aged; Platelet Activating Factor; Triazoles | 1995 |
Growth arrest vs direct cytotoxicity and the importance of molecular structure for the in vitro anti-tumour activity of ether lipids.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Cycle; Cell Division; Cell Membrane; Colonic Neoplasms; Drug Screening Assays, Antitumor; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Mammary Neoplasms, Experimental; Mice; Phospholipid Ethers; Platelet Activating Factor; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured | 1995 |
Mast cell mediators and peritoneal adhesion formation in the rat.
Topics: Animals; Azepines; Disease Models, Animal; Histamine Antagonists; Leukotriene D4; Male; Mast Cells; Methysergide; Ondansetron; Peritoneal Diseases; Platelet Activating Factor; Propionates; Pyrilamine; Quinolines; Ranitidine; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Tissue Adhesions; Triazoles | 1995 |
Protective effect of a specific PAF antagonist on vincristine-induced experimental retinopathy.
Topics: Animals; Azepines; Dark Adaptation; Electroretinography; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Thienopyridines; Triazoles; Vincristine | 1995 |
Novel antagonists of platelet-activating factor. 1. Synthesis and structure-activity relationships of benzodiazepine and benzazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine.
Topics: Animals; Azepines; Benzodiazepines; Imidazoles; Mice; Platelet Activating Factor; Pyridines; Rabbits; Structure-Activity Relationship; Thiazoles; Triazoles | 1995 |
Endothelin-1 induces neutrophil-independent vascular injury in the rat gastric microcirculation.
Topics: Animals; Azepines; Capillary Permeability; Disease Models, Animal; Endothelins; Endothelium, Vascular; Gastric Mucosa; Infusions, Intra-Arterial; Isotope Labeling; Male; Methacrylates; Neutrophils; Platelet Activating Factor; Rats; Rats, Wistar; Serum Albumin; Stomach Ulcer; Thromboxane-A Synthase; Triazoles | 1995 |
Platelet adhesion to cultured bovine cerebral microvascular endothelial cells by stimulation of platelet activating factor and antagonism of drugs.
Topics: Alkaloids; Animals; Azepines; Benzylisoquinolines; Brain; Cattle; Cells, Cultured; Endothelium, Vascular; Microcirculation; Platelet Activating Factor; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Triazoles | 1995 |
Platelet-activating factor antagonists (BN 52021 and BN 50730) inhibit tumor necrosis factor-alfa-mediated cytotoxicity on murine L929 tumor cells.
Topics: Animals; Aprotinin; Azepines; Cytotoxicity, Immunologic; Diterpenes; Dose-Response Relationship, Immunologic; Ginkgolides; Lactones; Mice; Platelet Activating Factor; Tetrazoles; Thienopyridines; Triazoles; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage.
Topics: Albumins; Animals; Arginine; Azepines; Blood Flow Velocity; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cyclic GMP; Intercellular Adhesion Molecule-1; Leukocytes; Male; NG-Nitroarginine Methyl Ester; P-Selectin; Phalloidine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Triazoles; Venules | 1993 |
Inhibition of leukocyte adhesion to endothelial cells of human umbilical vein by Y-24180, an antagonist of platelet-activating factor.
Topics: Animals; Antigens, CD; Azepines; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; E-Selectin; Edema; Endothelium, Vascular; Guinea Pigs; Humans; Intercellular Adhesion Molecule-1; Leukocytes; Male; Mice; Mice, Inbred BALB C; Platelet Activating Factor; Triazoles; Umbilical Veins | 1993 |
Activation of capsaicin-sensitive sensory fibers modulates PAF-induced bronchial hyperresponsiveness in anesthetized guinea pigs.
Topics: Anesthesia; Animals; Azepines; Bronchial Hyperreactivity; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Male; Nerve Fibers; Platelet Activating Factor; Ruthenium Red; Serum Albumin, Bovine; Time Factors; Triazoles | 1993 |
Platelet-activating factor contributes to the induction of nitric oxide synthase by bacterial lipopolysaccharide.
Topics: Amino Acid Oxidoreductases; Animals; Azepines; Blood Vessels; Cardiovascular System; Cells, Cultured; Enzyme Induction; Lipopolysaccharides; Macrophages; Male; Mice; Nitric Oxide Synthase; Nitrites; Platelet Activating Factor; Rats; Rats, Wistar; Triazoles; Vasomotor System | 1993 |
Increased prostaglandin I2 and thromboxane A2 production by rat dental pulp after intravenous administration of endotoxin.
Topics: Animals; Arachidonic Acid; Azepines; Dental Pulp; Endotoxins; Epoprostenol; Escherichia coli; Indomethacin; Injections, Intravenous; Jejunum; Lung; Male; Platelet Activating Factor; Rats; Rats, Wistar; Thromboxane A2; Time Factors; Triazoles | 1994 |
Treatment of carrageenan induced arthritis by the platelet activating factor antagonist BN 50730.
Topics: Animals; Arthritis, Experimental; Azepines; Carrageenan; Injections, Intra-Articular; Platelet Activating Factor; Rabbits; Thienopyridines; Triazoles | 1995 |
Platelet-activating factor mediates trinitrobenzene induced colitis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Colitis; Colon; Dinoprostone; Eicosanoids; Gastrointestinal Contents; Leukotriene B4; Platelet Activating Factor; Rabbits; Second Messenger Systems; Thromboxane B2; Triazoles; Trinitrobenzenesulfonic Acid | 1994 |
Interleukin-1-induced leukocyte extravasation across rat mesenteric microvessels is mediated by platelet-activating factor.
Topics: Animals; Azepines; Cell Adhesion; Chemotaxis, Leukocyte; Dihydropyridines; Edema; Imidazoles; Inflammation; Interleukin-1; Leukocytes; Male; Mesentery; Microcirculation; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Skin; Triazoles | 1995 |
Role of thromboxane A2 and platelet-activating factor in allergic bronchoconstriction in guinea pig airway in vivo.
Topics: Administration, Inhalation; Animals; Antigens; Asthma; Azepines; Bridged Bicyclo Compounds; Bronchoconstriction; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Guinea Pigs; Hypersensitivity; Male; Platelet Activating Factor; Receptors, Prostaglandin; Thromboxane A2; Triazoles | 1995 |
Mechanisms for lipoxin A4 induced neutrophil dependent cytotoxicity for human endothelial cells.
Topics: Azepines; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Leukotriene B4; Lipoxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Triazoles; Umbilical Veins; Virulence Factors, Bordetella | 1995 |
Evidence for the predominant role of intracellular PAF binding sites in the regulation of phospholipase A2 in human neutrophils.
Topics: Alkaloids; Azepines; Humans; Indoles; Leukotriene Antagonists; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staurosporine; Triazoles | 1995 |
The role of platelet-activating factor in lipopolysaccharide-induced myocardial depression in guinea pigs.
Topics: Animals; Azepines; Depression, Chemical; Drug Interactions; Escherichia coli; Female; Guinea Pigs; Isoproterenol; Lipopolysaccharides; Male; Myocardial Contraction; Phenylephrine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Quinolinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Time Factors; Triazoles | 1995 |
Platelet-activating factor increases vascular resistance in rat hindquarters by thromboxane A2.
Topics: Animals; Azepines; Blood Pressure; Capillary Permeability; Hindlimb; Ibuprofen; Male; Phenylacetates; Platelet Activating Factor; Rats; Rats, Wistar; Regional Blood Flow; Sulfonamides; Thromboxane A2; Thromboxanes; Triazoles; Vascular Resistance | 1995 |
Occurrence of disseminated intravascular coagulation (DIC) in active systemic anaphylaxis: role of platelet-activating factor.
Topics: Anaphylaxis; Animals; Azepines; Disseminated Intravascular Coagulation; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Platelet Activating Factor; Triazoles | 1995 |
Presence of specific platelet-activating factor binding-sites in neuroblastoma N1E-115 cells.
Topics: Animals; Azepines; Binding Sites; Binding, Competitive; Brain Neoplasms; Diterpenes; Ginkgolides; Kinetics; Lactones; Mice; Neuroblastoma; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles; Tumor Cells, Cultured | 1995 |
Platelet activating factor induces nerve growth factor production by rat astrocytes.
Topics: Animals; Astrocytes; Azepines; Cerebral Cortex; Enzyme-Linked Immunosorbent Assay; Kinetics; Nerve Growth Factors; Nerve Tissue Proteins; Platelet Activating Factor; Rats; Triazoles; Tumor Necrosis Factor-alpha | 1995 |
1-O-hexadecyl-2-metoxy-glycero-3-phosphatidylcholine--a methoxy ether lipid inhibiting platelet activating factor-induced platelet aggregation and neutrophil oxidative metabolism.
Topics: Azepines; Blood Platelets; Calcium; Humans; Luminescent Measurements; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Triazoles | 1995 |
Adenosine and PAF dependent mechanisms lead to myocardial reperfusion injury by neutrophils after brief ischaemia.
Topics: Adenosine; Animals; Azepines; Guinea Pigs; Heart; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Neutrophil Activation; Neutrophils; Perfusion; Platelet Activating Factor; Receptors, Purinergic P1; Theobromine; Triazoles; Xanthines | 1995 |
Platelet-activating factor mediates the ozone-induced increase in airway microvascular leakage in guinea pigs.
Topics: Animals; Azepines; Bronchi; Capillary Permeability; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Inflammation Mediators; Male; Ozone; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Physiological Phenomena; Respiratory System; Trachea; Triazoles | 1995 |
Platelet-activating factor receptor antagonist improves renal function and glomerular lesions in renal ablation.
Topics: Albuminuria; Animals; Azepines; Blood Pressure; Body Weight; Eicosanoids; Inulin; Kidney; Kidney Glomerulus; Male; Nephrectomy; Organ Size; p-Aminohippuric Acid; Platelet Activating Factor; Rats; Rats, Wistar; Triazoles | 1994 |
Pharmacological profile of UK-74,505, a novel and selective PAF antagonist with potent and prolonged oral activity.
Topics: Administration, Oral; Animals; Aorta; Azepines; Blood Platelets; Brain; Calcium Channels, L-Type; Capillary Permeability; Cattle; Dihydropyridines; Diltiazem; Gallopamil; Guinea Pigs; Hypotension; Imidazoles; In Vitro Techniques; Kinetics; Male; Membranes; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle Proteins; Nitrendipine; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Potassium Chloride; Rabbits; Rats; Rats, Sprague-Dawley; Skin; Triazoles; Tritium | 1994 |
Antagonism of neutrophil adherence in the deteriorating stroke model in rabbits.
Topics: Animals; Azepines; Cell Adhesion; Cerebrovascular Disorders; Ischemia; Male; Neutrophils; Platelet Activating Factor; Rabbits; Reperfusion Injury; Spinal Cord; Triazoles | 1995 |
Quantitative measurement of a new synthetic hetrazepine derivative, BN50730, in human plasma and urine by combined liquid chromatography-negative chemical ionization mass spectrometry using a particle beam interface.
Topics: Adult; Azepines; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Male; Mass Spectrometry; Platelet Activating Factor; Quality Control; Spectrophotometry, Ultraviolet; Thienopyridines; Triazoles | 1994 |
Evidence for a colonic PAF receptor.
Topics: Animals; Azepines; Colon; Eicosanoids; In Vitro Techniques; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1995 |
Platelet-activating factor and sepsis-induced small intestinal microvascular hypoperfusion.
Topics: Animals; Azepines; Bacteremia; Escherichia coli Infections; Intestine, Small; Male; Microcirculation; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles; Vasoconstriction | 1995 |
Permeability of ferret trachea in vitro to 99mTc-DTPA and [14C]antipyrine.
Topics: Animals; Antipyrine; Azepines; Cell Membrane Permeability; Epithelium; Female; Ferrets; Male; Membrane Potentials; Muscle, Smooth; Platelet Activating Factor; Technetium Tc 99m Pentetate; Trachea; Triazoles | 1994 |
Characterization of a behavioral model for peripherally evoked itch suggests platelet-activating factor as a potent pruritogen.
Topics: Animals; Azepines; Female; Guinea Pigs; Histamine; Male; Platelet Activating Factor; Pruritus; Pyridinium Compounds; Triazoles | 1995 |
Long-lasting inhibitory activity of the hetrazepinic BN 50730 on exudation and cellular alterations evoked by PAF and LPS.
Topics: Animals; Azepines; Cell Movement; Chemotaxis, Leukocyte; Exudates and Transudates; Female; Leukocytes; Lipopolysaccharides; Male; Platelet Activating Factor; Platelet Aggregation; Rabbits; Rats; Rats, Wistar; Thienopyridines; Triazoles | 1994 |
Interactions of constitutive nitric oxide with PAF and thromboxane on rat intestinal vascular integrity in acute endotoxaemia.
Topics: Animals; Azepines; Blood Pressure; Capillaries; Capillary Permeability; Cyclooxygenase Inhibitors; Diterpenes; Escherichia coli; Ginkgolides; Intestinal Mucosa; Intestines; Lactones; Lipopolysaccharides; Male; Nitric Oxide; Phenylephrine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Thromboxane; Thromboxane A2; Triazoles | 1994 |
Effects of platelet activating factor receptor antagonists on intracellular platelet activating factor function in neutrophils.
Topics: Animals; Azepines; Binding, Competitive; Calcium; Cell Count; Cell Degranulation; Chemotaxis, Leukocyte; Free Radical Scavengers; Inositol 1,4,5-Trisphosphate; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridines; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reference Standards; Signal Transduction; Structure-Activity Relationship; Superoxides; Thiazoles; Thiazolidines; Triazoles; Vitamin E | 1994 |
Effect of platelet activating factor antagonists in different models of thrombosis.
Topics: Animals; Arterial Occlusive Diseases; Azepines; Cats; Diterpenes; Ginkgolides; Lactones; Male; Mice; Mice, Inbred Strains; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Thiazoles; Thrombophlebitis; Triazoles | 1994 |
Functional PAF receptors in glia cells: binding parameters and regulation of expression.
Topics: Animals; Animals, Newborn; Astrocytes; Azepines; Bucladesine; Calcium; Calcium Radioisotopes; Cells, Cultured; Gene Expression Regulation, Developmental; Insulin; Kinetics; Nerve Tissue Proteins; Neuroglia; Oligodendroglia; Phenotype; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1994 |
The effects of anti-PAF and other agents on the nasal symptoms in sensitized guinea pigs.
Topics: Airway Resistance; Animals; Azepines; Chromones; Guinea Pigs; Histamine H1 Antagonists; Immunization; Lipoxygenase Inhibitors; Male; Ovalbumin; Phthalazines; Platelet Activating Factor; Pyrilamine; Rhinitis, Allergic, Perennial; Sneezing; SRS-A; Thiazoles; Thiazolidines; Triazoles | 1993 |
Molecular mechanisms involved in superoxide-induced leukocyte-endothelial cell interactions in vivo.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Azepines; Blood Pressure; Catalase; CD18 Antigens; Endothelium, Vascular; Free Radical Scavengers; Hypoxanthine; Hypoxanthines; Leukocytes; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Receptors, Leukocyte-Adhesion; Splanchnic Circulation; Superoxides; Triazoles; Xanthine Oxidase | 1994 |
Endothelial cell-associated platelet-activating factor primes neutrophils for enhanced superoxide production and arachidonic acid release during adhesion to but not transmigration across IL-1 beta-treated endothelial monolayers.
Topics: Arachidonic Acid; Azepines; Cell Adhesion; Cell Movement; Cell Polarity; Endothelium, Vascular; Humans; In Vitro Techniques; Interleukin-1; Neutrophil Activation; Neutrophils; Piperazines; Platelet Activating Factor; Superoxides; Thiazoles; Thiazolidines; Triazoles | 1994 |
Functional platelet-activating factor receptors linked to inositol lipid hydrolysis, calcium mobilization and tyrosine kinase activity in the human endometrial HEC-1B cell line.
Topics: Azepines; Calcium; Cell Line; Endometrium; Female; Fura-2; Humans; Hydrolysis; Inositol; Inositol 1,4,5-Trisphosphate; Lipid Metabolism; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1994 |
Modulatory role of protein kinase C on the signal transduction pathway utilized by platelet-activating factor in eosinophil activation.
Topics: Alkaloids; Animals; Azepines; Calcium; Cell Membrane; Cytosol; Eosinophil Peroxidase; Eosinophils; Guinea Pigs; Male; Peritoneal Lavage; Peroxidases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Triazoles | 1994 |
Determination of the platelet activating factor antagonist 6-(2- chlorophenyl)-9-[(4-methoxyphenyl)thiocarbamoyl]-1-methyl-7,8,9,10- tetrahydro-4H-pyrido[4',3'-4,5]-thieno[3,2-f][1,2,4]triazolo[4, 3-a][1,4] diazepine in human plasma by liquid chromatograp
Topics: Azepines; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Mass Spectrometry; Microchemistry; Platelet Activating Factor; Quality Control; Sensitivity and Specificity; Thienopyridines; Triazoles | 1994 |
Role of R-type calcium channels in the response of the perfused arterial and venous mesenteric vasculature of the rat to platelet-activating factor.
Topics: Animals; Arginine; Azepines; Calcium Channels; Isradipine; Male; Mesenteric Arteries; Mesenteric Veins; NG-Nitroarginine Methyl Ester; Perfusion; Platelet Activating Factor; Quinolinium Compounds; Rats; Rats, Wistar; Triazoles | 1994 |
WEB-2086 and indomethacin do not modify blood pressure fall on unclipping hypertensive rats.
Topics: Animals; Azepines; Blood Pressure; Disease Models, Animal; Hypertension, Renal; Indomethacin; Injections, Intravenous; Male; Platelet Activating Factor; Rats; Rats, Wistar; Renal Artery; Triazoles | 1994 |
Agonist-induced up-regulation of platelet-activating factor receptor messenger RNA in human monocytes.
Topics: Adult; Azepines; Gene Expression Regulation; Humans; Monocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Triazoles; Up-Regulation | 1994 |
Changes of cytosolic calcium ion concentrations in human endothelial cells in response to thrombin, platelet-activating factor, and leukotriene B4.
Topics: Azepines; Calcium; Cells, Cultured; Cytosol; Endothelium, Vascular; Fura-2; Humans; Ions; Leukotriene B4; Osmolar Concentration; Platelet Activating Factor; Thrombin; Triazoles | 1994 |
Interactions between leukotrienes and histamine in the anaphylactic contraction of guinea pig lung parenchyma.
Topics: Anaphylaxis; Animals; Azepines; Guinea Pigs; Histamine; In Vitro Techniques; Indoles; Indomethacin; Leukotriene Antagonists; Leukotrienes; Lung; Male; Muscle Contraction; Ovalbumin; Platelet Activating Factor; Quinolines; Triazoles | 1994 |
Delayed treatment with platelet activating factor receptor antagonist web 2086 attenuates pulmonary dysfunction in porcine endotoxin shock.
Topics: Animals; Azepines; Blood Pressure; Cathepsin B; Creatinine; Extravascular Lung Water; Hypertension, Pulmonary; Lipopolysaccharides; Lung; Platelet Activating Factor; Pulmonary Artery; Pulmonary Gas Exchange; Salmonella; Shock, Septic; Swine; Swine, Miniature; Triazoles; Tumor Necrosis Factor-alpha; Vascular Resistance | 1994 |
[Effects of calcimycin on platelet adhesion to cultured bovine cerebral microvascular endothelial cells and its antagonism by drugs].
Topics: Alkaloids; Animals; Azepines; Benzylisoquinolines; Brain; Calcimycin; Cattle; Cells, Cultured; Endothelium, Vascular; Male; Microcirculation; Platelet Activating Factor; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Pyrans; Rabbits; Triazoles | 1994 |
Platelet-activating factor induced calcium mobilization and phosphoinositide metabolism in cultured bovine cerebral microvascular endothelial cells.
Topics: Animals; Azepines; Brain; Calcium; Calcium Channel Blockers; Cattle; Cells, Cultured; Endothelium, Vascular; Phosphatidylinositols; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles | 1994 |
Platelet-activating factor and WEB-2086 directly modulate rat cardiomyocyte contractility.
Topics: Animals; Azepines; In Vitro Techniques; Kinetics; Myocardial Contraction; Myocardium; Platelet Activating Factor; Rats; Rats, Inbred WKY; Triazoles | 1994 |
Effect of platelet activating factor antagonist WEB 2086 on the production of TNF from murine peritoneal macrophages.
Topics: Animals; Azepines; Biological Assay; Fibrosarcoma; Macrophages, Peritoneal; Mice; Mice, Inbred ICR; Platelet Activating Factor; Triazoles; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro.
Topics: Animals; Azepines; Cell Division; Colony-Stimulating Factors; Female; Interleukin-1; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Phagocytosis; Platelet Activating Factor; Spleen; Triazoles | 1994 |
Pharmacological analysis of neutrophil chemotactic factor production by leucocytes and roles of PAF in allergic inflammation in rats.
Topics: Animals; Azepines; Benzoquinones; Cells, Cultured; Culture Media, Conditioned; Dose-Response Relationship, Drug; Furans; Hypersensitivity; Immunization; Interleukin-8; Isoelectric Focusing; Leukocytes; Lipoxygenase Inhibitors; Phospholipid Ethers; Platelet Activating Factor; Rats; Triazoles | 1994 |
Protection from BB rat diabetes by the platelet-activating factor inhibitor BN50730.
Topics: Age Factors; Animals; Autoimmune Diseases; Azepines; Diabetes Mellitus, Type 1; Insulin; Islets of Langerhans; Male; Platelet Activating Factor; Rats; Rats, Inbred BB; Tetrazoles; Thienopyridines; Thyroid Gland; Thyroiditis, Autoimmune; Triazoles | 1993 |
A flow cytometric assay reveals an enhancement of phagocytosis by platelet activating factor in murine peritoneal macrophages.
Topics: Animals; Azepines; Calcium; Female; Flow Cytometry; In Vitro Techniques; Latex; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Phagocytosis; Phospholipid Ethers; Platelet Activating Factor; Triazoles | 1994 |
Lipopolysaccharide-induced pleural neutrophil accumulation depends on marrow neutrophils and platelet-activating factor.
Topics: Animals; Azepines; Bone Marrow; Bone Marrow Cells; Cell Cycle; Cell Movement; Dihydropyridines; Escherichia coli; Injections; Kinetics; Leukocyte Count; Lipopolysaccharides; Male; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pleura; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thorax; Triazoles | 1994 |
Role of type 1 and type 2A phosphatases in signal transduction of platelet-activating-factor-stimulated rabbit platelets.
Topics: Animals; Azepines; Blood Platelets; Calcium; Cations, Divalent; Indoles; Inositol 1,4,5-Trisphosphate; Ionomycin; Maleimides; Manganese; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Rabbits; Signal Transduction; Triazoles | 1994 |
Hyperalgesia induced by Bothrops jararaca venom in rats: role of eicosanoids and platelet activating factor (PAF).
Topics: Animals; Azepines; Bothrops; Crotalid Venoms; Dexamethasone; Diterpenes; Dose-Response Relationship, Drug; Eicosanoids; Fibrinolytic Agents; Ginkgolides; Hyperalgesia; Indomethacin; Lactones; Male; Platelet Activating Factor; Rats; Rats, Wistar; Triazoles | 1994 |
Dual effects of a novel thienodiazepine platelet-activating factor antagonist, on drug-oxidizing enzymes in beagle dog.
Topics: Animals; Antipyrine; Azepines; Cytochrome P-450 Enzyme System; Dogs; Half-Life; Male; Metabolic Clearance Rate; Microsomes, Liver; Nitroanisole O-Demethylase; Oxidoreductases, N-Demethylating; Platelet Activating Factor; Regression Analysis; Triazoles; Trimethadione | 1994 |
The effect of a free radical scavenger and platelet-activating factor antagonist on FFA accumulation in post-ischemic canine brain.
Topics: Animals; Arachidonic Acids; Azepines; Brain; Dimethyl Sulfoxide; Dogs; Fatty Acids, Nonesterified; Free Radical Scavengers; In Vitro Techniques; Ischemic Attack, Transient; Oleic Acids; Palmitic Acids; Platelet Activating Factor; Reperfusion; Stearic Acids; Triazoles | 1994 |
Histologic and ultrastructural changes after large-colon torsion, with and without use of a specific platelet-activating factor antagonist (WEB 2086), in ponies.
Topics: Animals; Azepines; Colon; Colonic Diseases; Edema; Epithelium; Female; Horse Diseases; Horses; Intestinal Mucosa; Male; Microscopy, Electron; Necrosis; Neutrophils; Platelet Activating Factor; Torsion Abnormality; Triazoles | 1994 |
[Lung 3H-thymidine incorporation in monocrotaline (MCT)-treated rats--role of platelet-activating factor (PAF)].
Topics: Animals; Azepines; DNA; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Thymidine; Triazoles | 1994 |
Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CD11b, and ICAM-1.
Topics: Antibodies, Monoclonal; Antigens, CD; Azepines; Biological Assay; CD11 Antigens; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cell Hypoxia; Cells, Cultured; Endothelium, Vascular; Gas Chromatography-Mass Spectrometry; Humans; Intercellular Adhesion Molecule-1; Interleukin-1; Kinetics; Neutrophils; Oleic Acid; Oleic Acids; Platelet Activating Factor; Recombinant Proteins; Stearic Acids; Time Factors; Triazoles; Umbilical Veins | 1993 |
Platelet-activating factor inhibits excitatory transmission in rat neostriatum.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Azepines; Glutamates; Glutamic Acid; Neostriatum; Neural Inhibition; Platelet Activating Factor; Platelet Membrane Glycoproteins; Quinoxalines; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1993 |
Hyperacute rejection in an ex vivo model of renal xenografting. Role of the mediator response and its pharmacologic manipulation by the specific platelet-activating factor antagonist WEB 2086BS.
Topics: Adult; Animals; Antibodies, Heterophile; Antibody Formation; Azepines; Female; Graft Rejection; Hematocrit; Hemoglobins; Humans; Inflammation; Kidney; Kidney Transplantation; Male; Perfusion; Platelet Activating Factor; Pressure; Prostaglandins; Swine; Transplantation, Heterologous; Triazoles; Tumor Necrosis Factor-alpha; Vascular Resistance | 1994 |
Binding and metabolism of platelet-activating factor (PAF) by isolated rat type II pneumonocytes.
Topics: Animals; Azepines; Biotransformation; Cells, Cultured; Kinetics; Lung; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1994 |
Interactions between synthesis of platelet-activating factor and leukotriene B4 in isolated human polymorphonuclear leukocytes.
Topics: Arachidonate 5-Lipoxygenase; Azepines; Calcimycin; Chemotaxis, Leukocyte; Drug Interactions; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Leukotriene B4; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1993 |
Platelet-activating factor as a potential retrograde messenger in CA1 hippocampal long-term potentiation.
Topics: Action Potentials; Animals; Azepines; Diterpenes; Ginkgolides; Hippocampus; In Vitro Techniques; Lactones; Long-Term Potentiation; Male; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetrazoles; Thienopyridines; Triazoles | 1994 |
A comparison of the actions of platelet activating factor (PAF) antagonists WEB 2170 and WEB 2086 in the horse.
Topics: Animals; Azepines; Capillary Permeability; Dose-Response Relationship, Drug; Histamine; Horses; Leukocyte Count; Male; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Skin; Triazoles | 1993 |
In vitro modulation of interleukin-1 beta secretion by cultured rat doxorubicin-stimulated whole glomeruli and dissociated mesangial glomerular cells.
Topics: Animals; Azepines; Cells, Cultured; Dose-Response Relationship, Drug; Doxorubicin; Drug Interactions; Glomerular Mesangium; Interleukin-1; Kidney Glomerulus; Kinetics; Lipopolysaccharides; Male; Molecular Weight; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles | 1994 |
Effect of a platelet-activating factor antagonist, WEB 2086, on inhibition of active oxygen generation in human polymorphonuclear leukocytes.
Topics: Azepines; Free Radicals; Humans; Hydroxyl Radical; Neutrophils; Platelet Activating Factor; Superoxides; Triazoles | 1994 |
Platelet-activating factor is a messenger in the electroconvulsive shock-induced transcriptional activation of c-fos and zif-268 in hippocampus.
Topics: Animals; Azepines; Base Sequence; DNA-Binding Proteins; Early Growth Response Protein 1; Electroshock; Gene Expression Regulation; Hippocampus; Immediate-Early Proteins; Male; Microsomes; Molecular Sequence Data; Neuronal Plasticity; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Seizures; Synaptic Membranes; Tetrazoles; Thienopyridines; Transcription Factors; Transcription, Genetic; Triazoles; Zinc Fingers | 1994 |
Gastrointestinal physiology-regulated dogs: utilization of a bioavailability study of a new thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]-diazepine, an antagonist of platelet-activating factor, and its preparations.
Topics: Administration, Oral; Animals; Atropine; Azepines; Biological Availability; Chromatography, High Pressure Liquid; Dogs; Dosage Forms; Humans; Injections, Intravenous; Intestinal Absorption; Male; Pentagastrin; Platelet Activating Factor; Solubility; Tablets; Triazoles | 1994 |
Platelet activating factor impairs pressor responses to noradrenaline in the anaesthetized rat but does not mediate endotoxin-induced hyporeactivity.
Topics: Anesthesia; Animals; Azepines; Blood Circulation; Blood Pressure; Endotoxins; Male; Norepinephrine; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles | 1994 |
Effect of the platelet-activating factor antagonist BN 50739 and its diluents on mitochondrial respiration and membrane lipids during and following cerebral ischemia.
Topics: Animals; Azepines; Brain; Fatty Acids, Nonesterified; Intracellular Membranes; Ischemic Attack, Transient; Lipid Peroxidation; Male; Membrane Lipids; Mitochondria; Oxygen Consumption; Phospholipids; Platelet Activating Factor; Prosencephalon; Rats; Rats, Sprague-Dawley; Triazoles | 1994 |
Role of platelet-activating factor (PAF) in oxygen radical-induced cardiac dysfunction.
Topics: Animals; Azepines; Free Radicals; Fumarates; Guinea Pigs; Heart; In Vitro Techniques; Myocardium; Platelet Activating Factor; Reactive Oxygen Species; Superoxide Dismutase; Triazoles | 1994 |
Rat liver blood flow after ischemia and reperfusion. The effects of the platelet-activating factor antagonist WEB-2170 and of removing circulating leukocytes.
Topics: Animals; Azepines; Liver; Liver Circulation; Male; Neutrophils; Oxyhemoglobins; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Reperfusion Injury; Triazoles; Vinblastine | 1994 |
Mast cell activation augments gastric mucosal injury through a leukotriene-dependent mechanism.
Topics: Animals; Azepines; Blood Pressure; Chymases; Dexamethasone; Gastric Mucosa; Leukotriene Antagonists; Leukotrienes; Male; Mast Cells; Nippostrongylus; Platelet Activating Factor; Propionates; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Leukotriene; Reference Values; Regional Blood Flow; Serine Endopeptidases; Stomach; Strongylida Infections; Triazoles | 1994 |
Development of radioimmunoassay for the novel platelet activating factor receptor antagonist, E6123, and its application to pharmacokinetics in laboratory animals.
Topics: Animals; Azepines; Biological Availability; Chromatography, High Pressure Liquid; Cross Reactions; Dogs; Guinea Pigs; Haptens; Immune Sera; Macaca mulatta; Male; Platelet Activating Factor; Rabbits; Radioimmunoassay; Sensitivity and Specificity; Serum Albumin, Bovine; Spectrophotometry, Ultraviolet; Triazoles | 1994 |
The platelet-activating factor antagonist WEB 2170. Its beneficial effect on dog renal allograft survival.
Topics: Animals; Azepines; Cyclosporine; Dogs; Drug Therapy, Combination; Graft Survival; Immunosuppression Therapy; Kidney Transplantation; Platelet Activating Factor; Survival Analysis; Transplantation, Homologous; Triazoles | 1993 |
Pharmacokinetics of a new thienodiazepine platelet activating factor receptor antagonist (E6123) in laboratory animals. Is there a metabolic polymorphism in the rhesus monkey?
Topics: Animals; Azepines; Biological Availability; Blood Proteins; Chromatography, High Pressure Liquid; Dogs; Guinea Pigs; Macaca mulatta; Male; Platelet Activating Factor; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Triazoles | 1993 |
Metabolic polymorphism of E6123 in rhesus monkey.
Topics: Animals; Azepines; Erythrocytes; Feces; Hydrogen-Ion Concentration; Kinetics; Macaca mulatta; Male; Platelet Activating Factor; Polymorphism, Genetic; Triazoles | 1993 |
Effect of platelet-activating factor (PAF) receptor blockers on smooth muscle cell replication in vitro and allograft arteriosclerosis in vivo.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Autoradiography; Azepines; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Fibroblasts; Male; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Inbred WF; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Transplantation, Homologous; Triazoles | 1993 |
Platelet activating factor and histamine effects in synovial blood flow evaluated by laser-Doppler flowmetry.
Topics: Animals; Azepines; Female; Histamine; Laser-Doppler Flowmetry; Male; Platelet Activating Factor; Rabbits; Regional Blood Flow; Synovial Membrane; Triazoles; Vasoconstriction | 1993 |
Platelet-activating-factor-induced augmentation of production of eosinophil-lineage cells in hematopoietic precursor cells obtained from human umbilical cord blood.
Topics: Azepines; Cell Differentiation; Cells, Cultured; Cytokines; Enzyme-Linked Immunosorbent Assay; Eosinophils; Fetal Blood; Gene Expression; Hematopoietic Stem Cells; Humans; Interleukin-3; Platelet Activating Factor; Polymerase Chain Reaction; RNA, Messenger; Triazoles | 1993 |
PAF activation of a voltage-gated R-type Ca2+ channel in human and canine aortic endothelial cells.
Topics: Azepines; Calcium Channel Blockers; Calcium Channels; Electrophysiology; Endothelium, Vascular; Fura-2; Humans; Image Processing, Computer-Assisted; In Vitro Techniques; Ion Channel Gating; Isradipine; Male; Platelet Activating Factor; Potassium; Triazoles | 1993 |
Partial agonist effect of the platelet-activating factor receptor antagonists, WEB 2086 and WEB 2170, in the rat perfused heart.
Topics: Animals; Azepines; Heart; In Vitro Techniques; Leukotrienes; Perfusion; Platelet Activating Factor; Platelet Membrane Glycoproteins; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Vasoconstriction; Vasodilation | 1993 |
Biochemical and pharmacological properties of SR 27388, a dual antioxidant and PAF receptor antagonist.
Topics: Animals; Antioxidants; Azepines; Blood Glucose; Blood Platelets; Cattle; Diabetes Mellitus, Experimental; Free Radical Scavengers; Humans; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Mitochondria, Heart; Monocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock, Septic; Superoxides; Sympathomimetics; Thiazoles; Thiobarbituric Acid Reactive Substances; Triazoles | 1993 |
Prevention of chloroquine-induced electroretinographic damage by a new platelet-activating factor antagonist, BN 50730.
Topics: Animals; Azepines; Chloroquine; Dark Adaptation; Electroretinography; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Tetrazoles; Thienopyridines; Triazoles | 1993 |
Role of cyclooxygenase and 5-lipoxygenase metabolites, platelet-activating factor and 5-hydroxytryptamine in allergen-induced airway responses in the brown Norway rat.
Topics: Allergens; Animals; Arachidonate 5-Lipoxygenase; Asthma; Azepines; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Hypersensitivity, Immediate; Male; Methysergide; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred BN; Serotonin; Triazoles | 1994 |
Two distinct signal transduction pathways for the activation of guinea-pig macrophages and neutrophils by endotoxin.
Topics: Animals; Azepines; Calcium; Chloride Channels; Cloning, Molecular; Endotoxins; Escherichia coli; Female; Guinea Pigs; L Cells; Lipid A; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Membrane Potentials; Mice; Neutrophils; Oocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Signal Transduction; Superoxides; Triazoles; Tumor Necrosis Factor-alpha; Xenopus laevis | 1993 |
Differential sensitivity of mouse strains to platelet activating factor-induced vasopermeability and mortality: effect of antagonists.
Topics: Animals; Azepines; Capillary Permeability; Coloring Agents; Diterpenes; Evans Blue; Ginkgolides; Lactones; Mice; Mice, Inbred A; Mice, Inbred BALB C; Platelet Activating Factor; Species Specificity; Triazoles | 1993 |
Platelet activating factor (PAF) enhances mitosis in preimplantation mouse embryos.
Topics: Animals; Azepines; Blastocyst; Cell Count; Culture Techniques; Female; Mice; Mitosis; Mitotic Index; Platelet Activating Factor; Triazoles | 1993 |
Transforming growth factor-beta up-regulates the gene expression of the human platelet-activating factor receptor in monocytic and B cell lines.
Topics: Azepines; B-Lymphocytes; Calcium; Cell Line; Cycloheximide; Dactinomycin; Gene Expression; Humans; Ionomycin; Kinetics; Monocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Time Factors; Transcription, Genetic; Transforming Growth Factor beta; Triazoles; Tumor Cells, Cultured; Up-Regulation | 1993 |
Effects of dauricine and tetrandrine on [3H] WEB 2086 specific binding to bovine anterior cerebral arterial smooth muscle cells in vitro.
Topics: Alkaloids; Animals; Azepines; Benzylisoquinolines; Binding Sites; Cattle; Cerebral Arteries; Isoquinolines; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetrahydroisoquinolines; Triazoles | 1993 |
Endotoxin-induced pulmonary leukostasis in the rat: role of platelet-activating factor and tumor necrosis factor.
Topics: Animals; Azepines; Endotoxins; Lipopolysaccharides; Lung; Male; Neutrophils; Peroxidase; Platelet Activating Factor; Quinolinium Compounds; Rats; Rats, Sprague-Dawley; Triazoles; Tumor Necrosis Factor-alpha | 1994 |
Tumour necrosis factor and endotoxin synergistically activate intestinal phospholipase A2 in mice. Role of endogenous platelet activating factor and effect of exogenous platelet activating factor.
Topics: Animals; Azepines; Drug Synergism; Endotoxins; Enzyme Activation; Intestines; Lipopolysaccharides; Male; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Quinolinium Compounds; Stimulation, Chemical; Triazoles; Tumor Necrosis Factor-alpha | 1994 |
Compounds biologically similar to platelet activating factor are present in stored blood components.
Topics: Azepines; Blood Preservation; Gas Chromatography-Mass Spectrometry; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Platelet Activating Factor; Radioimmunoassay; Triazoles | 1993 |
Triazolobenzodiazepines: a new class of stimulators of tissue-type plasminogen activator synthesis in human endothelial cells.
Topics: Benzodiazepines; Cells, Cultured; Endothelium, Vascular; Humans; Plasminogen Activator Inhibitor 1; Platelet Activating Factor; RNA, Messenger; Structure-Activity Relationship; Tissue Plasminogen Activator; Triazoles | 1993 |
Experimental otitis media with effusion induced by platelet activating factor.
Topics: Animals; Azepines; Chinchilla; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Otitis Media with Effusion; Platelet Activating Factor; Temporal Bone; Time Factors; Triazoles | 1993 |
Involvement of platelet-activating factor (PAF) in endotoxin- or ischaemia-induced intestinal hyperpermeability in the rat.
Topics: Allopurinol; Animals; Azepines; Endotoxins; Free Radical Scavengers; Intestinal Mucosa; Intestines; Male; Permeability; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Thienopyridines; Triazoles; Xanthine Oxidase | 1993 |
Platelet-activating factor induces collagenase expression in corneal epithelial cells.
Topics: Animals; Azepines; Base Sequence; Blotting, Northern; Collagenases; Cornea; Cycloheximide; Epithelium; Gene Expression; Genes, fos; Genes, jun; Kinetics; Molecular Sequence Data; Oligodeoxyribonucleotides; Organ Culture Techniques; Platelet Activating Factor; Rabbits; RNA, Messenger; Tetrazoles; Thienopyridines; Triazoles | 1993 |
Platelet-activating factor-induced human eosinophil transendothelial migration: evidence for a dynamic role of the endothelium.
Topics: Azepines; Cells, Cultured; Chemotaxis, Leukocyte; Endothelium, Vascular; Eosinophils; Humans; Leukotriene B4; Microscopy, Electron; Neutrophils; Platelet Activating Factor; Triazoles | 1993 |
Role of PAF in the allergic pleurisy caused by ovalbumin in actively sensitized rats.
Topics: Analysis of Variance; Animals; Azepines; Chemotactic Factors, Eosinophil; Diterpenes; Drug Hypersensitivity; Eosinophils; Female; Freund's Adjuvant; Ginkgolides; Inflammation; Lactones; Leukocyte Count; Male; Oligopeptides; Ovalbumin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pleurisy; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1993 |
Mediators of the hypotensive response to increased renal perfusion in rabbits.
Topics: Animals; Azepines; Blood Pressure; Diuresis; Enalaprilat; Hemodynamics; Hypotension; Indomethacin; Natriuresis; Perfusion; Platelet Activating Factor; Pressure; Rabbits; Renal Circulation; Triazoles | 1993 |
Pharmacological characterization of a receptor for platelet-activating factor on guinea pig peritoneal macrophages using [3H]apafant, a selective and competitive platelet-activating factor antagonist: evidence that the noncompetitive behavior of apafant i
Topics: Animals; Azepines; Binding, Competitive; Guinea Pigs; In Vitro Techniques; Kinetics; Macrophages; Male; Peritoneal Cavity; Platelet Activating Factor; Platelet Membrane Glycoproteins; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Burst; Triazoles | 1993 |
Role of platelet-activating factor in hypotension and platelet activation induced by infusion of thrombolytic agents in rabbits.
Topics: Animals; Azepines; Female; Hypotension; Male; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Quinolines; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Streptokinase; Tissue Plasminogen Activator; Triazoles | 1993 |
Platelet-activating factor-induced enhancement of superoxide anion generation in guinea-pigs.
Topics: Animals; Azepines; Guinea Pigs; Injections, Intravenous; Luminescent Measurements; Macrophages, Alveolar; Male; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Thromboxane; Superoxides; Thromboxane A2; Triazoles | 1993 |
PAF-induced death in NMRI mice--a suitable shock model for testing new PAF receptor antagonists. Correlation with eicosanoid related substances.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Azepines; Disease Models, Animal; Diterpenes; Eicosanoids; Female; Ginkgolides; Lactones; Masoprocol; Mice; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock; Species Specificity; Triazoles | 1993 |
Platelet activating factor stimulates a receptor-coupled membrane GTPase in guinea pig eosinophils.
Topics: Animals; Azepines; Binding, Competitive; Cell Membrane; Cholera Toxin; Enzyme Activation; Eosinophils; GTP Phosphohydrolases; Guinea Pigs; Male; Nerve Tissue Proteins; Pertussis Toxin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinases; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Substrate Specificity; Triazoles; Virulence Factors, Bordetella | 1993 |
Mechanism and regulation of neutrophil priming by platelet-activating factor.
Topics: Adult; Amiloride; Azepines; Calcium; Chelating Agents; Diacylglycerol Kinase; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphotransferases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Pyrimidinones; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Tetradecanoylphorbol Acetate; Thiazoles; Triazoles; Type C Phospholipases; Virulence Factors, Bordetella | 1993 |
Meningocortical lesion increases expression of the cholecystokinin gene in rat cerebral cortex: evidence for the involvement of platelet-activating factor (PAF).
Topics: Animals; Azepines; Cerebral Cortex; Cholecystokinin; Gene Expression Regulation; Lipoxygenase; Male; Meninges; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1993 |
Transcriptional modulation of platelet-activating factor receptor gene expression by cyclic AMP.
Topics: Animals; Azepines; Bucladesine; Calcium; Cell Membrane; Cells, Cultured; Cricetinae; Cyclic AMP; Cycloheximide; Dinoprostone; Flow Cytometry; Gene Expression Regulation; Humans; Kinetics; Monocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Transcription, Genetic; Triazoles | 1993 |
Mediators of leukocyte adhesion in rat mesenteric venules elicited by inhibition of nitric oxide synthesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Azepines; Benzopyrans; Blood Pressure; Cell Adhesion; Cell Communication; Cell Movement; Leukocytes; Leukotriene B4; Mesenteric Veins; Microscopy; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Quinacrine; Rats; Rats, Inbred WKY; Regional Blood Flow; Triazoles; Venules | 1993 |
Platelet activating factor-induced microvascular permeability increases in the cat hindlimb.
Topics: Animals; Azepines; Capillary Permeability; Cats; Cimetidine; Diphenhydramine; Endothelium, Vascular; Hindlimb; Histamine; Isoproterenol; Leukocyte Count; Leukocytes; Platelet Activating Factor; Triazoles | 1993 |
Bronchopulmonary responses to endothelin-1 in sensitized and challenged guinea-pigs: role of cyclooxygenase metabolites and platelet-activating factor.
Topics: Aerosols; Animals; Azepines; Bronchi; Disease Models, Animal; Endothelins; Glycopeptides; Guinea Pigs; Immunization; Indomethacin; Lung; Male; Neprilysin; Ovalbumin; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Respiratory Function Tests; Tetrazoles; Thienopyridines; Time Factors; Triazoles | 1993 |
Autocrine amplification of PAF-acether formation in immunologically activated murine macrophages.
Topics: Acetyl Coenzyme A; Acyl Coenzyme A; Animals; Azepines; Cells, Cultured; Chromatography, High Pressure Liquid; Diterpenes; Female; Ginkgolides; Kinetics; Lactones; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mycobacterium bovis; Platelet Activating Factor; Triazoles | 1993 |
Effect of 5-lipoxygenase and cyclooxygenase blockade on porcine hemodynamics during continuous infusion of platelet-activating factor.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Blood; Calcimycin; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Hemodynamics; Hypertension, Pulmonary; In Vitro Techniques; Indomethacin; Infusions, Intra-Arterial; Leukotriene B4; Lipoxygenase Inhibitors; Naphthoquinones; ortho-Aminobenzoates; Platelet Activating Factor; Swine; Thromboxane B2; Triazoles | 1993 |
Role of leukotrienes and platelet activating factor in allergic bronchoconstriction and their interactions in guinea pig airway in vivo.
Topics: Animals; Asthma; Azepines; Bronchoconstriction; Bronchodilator Agents; Guinea Pigs; Leukotriene Antagonists; Leukotrienes; Male; Platelet Activating Factor; Pyridines; Pyrimidinones; Respiratory Hypersensitivity; Tetrazoles; Triazoles | 1993 |
Human platelets secrete chemotactic activity for eosinophils.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Azepines; Blood Platelets; Calcium; Chemotactic Factors; Chemotaxis, Leukocyte; Cytoplasmic Granules; Cytosol; Eosinophils; Humans; Platelet Activating Factor; Platelet Factor 4; Platelet Storage Pool Deficiency; Prostaglandin Endoperoxides; Thromboxane A2; Triazoles | 1993 |
Cardiovascular responses to exogenous platelet-activating factor (PAF) in anesthetized ponies, and the effects of a PAF antagonist, WEB 2086.
Topics: Anesthesia, Intravenous; Animals; Azepines; Blood Pressure; Clonixin; Female; Horses; In Vitro Techniques; Male; Platelet Activating Factor; Platelet Aggregation; Triazoles | 1993 |
Role of platelet-activating factor in polymorphonuclear neutrophil recruitment in reperfused ischemic rabbit heart.
Topics: Animals; Azepines; Cell Movement; Female; Heart; Hemodynamics; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Neutrophils; Platelet Activating Factor; Quinolines; Rabbits; Risk Factors; Triazoles | 1993 |
Roles of platelet-activating factor, thromboxane A2, ADP and thrombin in thrombogenesis in the guinea pig.
Topics: Adenosine Diphosphate; Animals; Azepines; Biphenyl Compounds; Guinea Pigs; Heptanoic Acids; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2; Ticlopidine; Triazoles | 1993 |
Platelet-activating factor and the vascular effects of zymosan in rats.
Topics: Animals; Azepines; Blood Pressure; Capillary Permeability; Female; Hematocrit; Hemodynamics; Iodine Radioisotopes; Male; Muscle, Smooth, Vascular; Platelet Activating Factor; Rats; Rats, Wistar; Thiazoles; Thiazolidines; Triazoles; Zymosan | 1993 |
Effect of inhaled lyso-platelet-activating factor on airway microvascular leakage in the guinea pig.
Topics: Administration, Inhalation; Aerosols; Airway Resistance; Animals; Azepines; Blood Pressure; Bronchoconstriction; Capillary Permeability; Dose-Response Relationship, Drug; Evans Blue; Female; Guinea Pigs; Injections, Intravenous; Lysophosphatidylcholines; Platelet Activating Factor; Respiratory Function Tests; Respiratory System; Triazoles | 1993 |
The effects of combined histamine and platelet-activating factor antagonism on systemic anaphylaxis induced by immunoglobulin E in the rabbit.
Topics: Airway Resistance; Anaphylaxis; Animals; Azepines; Basophil Degranulation Test; Blood Pressure; Chlorpheniramine; Cimetidine; Histamine; Immunoglobulin E; Leukocyte Count; Lung Compliance; Platelet Activating Factor; Rabbits; Serotonin; Tidal Volume; Triazoles | 1993 |
Platelet-activating factor: a mediator of pancreatic inflammation during cerulein hyperstimulation.
Topics: Animals; Azepines; Calcium; Ceruletide; Male; Osmolar Concentration; Pancreas; Pancreatitis; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles | 1993 |
Effect of a specific platelet-activating factor antagonist on cardiovascular and peripheral cellular responses to colonic ischemia and reperfusion in anesthetized ponies.
Topics: Analysis of Variance; Animals; Azepines; Blood Pressure; Body Temperature; Cardiac Output; Colon; Female; Heart Rate; Hemodynamics; Horses; Ischemia; Leukocyte Count; Male; Orchiectomy; Platelet Activating Factor; Pulmonary Circulation; Reperfusion; Triazoles; Vascular Resistance | 1993 |
Involvement of platelet-activating factor in death following anaphylactic shock in boosted and in unboosted mice.
Topics: Anaphylaxis; Animals; Azepines; Immunization, Secondary; Immunoglobulin E; Immunoglobulin G; Male; Mice; Ovalbumin; Platelet Activating Factor; Triazoles; Vaccination | 1993 |
Platelet-activating factor preferentially stimulates the phospholipase A2/cyclooxygenase cascade in the rabbit cornea.
Topics: Animals; Arachidonic Acid; Azepines; Cornea; Dinoprostone; Female; In Vitro Techniques; Male; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rabbits; Thienopyridines; Triazoles | 1995 |
Signaling by E-selectin and ICAM-1 induces endothelial tissue factor production via autocrine secretion of platelet-activating factor and tumor necrosis factor alpha.
Topics: Antigen-Antibody Reactions; Azepines; Cells, Cultured; E-Selectin; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Signal Transduction; Stimulation, Chemical; Thromboplastin; Triazoles; Tumor Necrosis Factor-alpha | 1995 |
Plasma mediated neutrophil stimulation during coronary angioplasty: autocrine effect of platelet activating factor.
Topics: Angioplasty, Balloon, Coronary; Azepines; CD18 Antigens; Cells, Cultured; Coronary Circulation; Diterpenes; Femoral Artery; Femoral Vein; Ginkgolides; Humans; Lactones; Myocardial Ischemia; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Superoxides; Triazoles | 1995 |
[The roles of platelet activating factor in intestinal mucosal barrier injury after burn].
Topics: Animals; Azepines; Burns; Female; Intestinal Mucosa; Male; Membrane Potentials; Peroxidase; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Triazoles | 1995 |
Role of PAF in the late airway microvascular leakage induced by antigen in IgE-sensitized rat.
Topics: Administration, Oral; Animals; Antigens; Azepines; Bronchi; Capillary Permeability; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Immunoglobulin E; Injections, Intravenous; Male; Methysergide; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Specific Pathogen-Free Organisms; Thienopyridines; Trachea; Triazoles | 1995 |
Activation of large conductance Ca(2+)-activated K+ channels in N1E-115 neuroblastoma cells by platelet-activating factor.
Topics: Azepines; Calcium; Ion Channel Gating; Membrane Potentials; Neuroblastoma; Neurons; Platelet Activating Factor; Potassium Channels; Triazoles; Tumor Cells, Cultured | 1996 |
Platelet-activating factor mediates pulmonary macromolecular leak following intestinal ischemia-reperfusion.
Topics: Animals; Azepines; Capillary Permeability; Hemodynamics; Intestines; Ischemia; Lung; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Triazoles | 1996 |
Alkyl-PAF and acyl-PAF human neutrophil priming for enhanced fMLP- and rC5a-induced superoxide anion production.
Topics: Adrenergic beta-Antagonists; Amino Acid Sequence; Anions; Azepines; Complement C5a; Drug Synergism; Female; Humans; Male; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphatidylcholines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Recombinant Proteins; Superoxides; Triazoles | 1996 |
Platelet activating factor receptor blockade alone or in combination with leukotriene synthesis inhibition does not ameliorate alpha-naphthylisothiocyanate-induced hepatotoxicity.
Topics: 1-Naphthylisothiocyanate; Animals; Azepines; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Liver; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles | 1996 |
Formation of a highly stable complex between BN 50730 [tetrahydro-4,7,8,10 methyl-1(chloro-2 phenyl)-6 (methoxy-4 phenyl-carbamoyl)-9 pyrido [4',3'-4,5] thieno [3,2-f] triazolo-1,2,4 [4,3-a] diazepine-1,4] and the platelet-activating factor receptor in ra
Topics: Animals; Azepines; Binding Sites; Blood Platelets; Cell Membrane; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles | 1996 |
PAF-induced airways hyperreactivity is modulated by mast cells in mice.
Topics: Acetylcholine; Analysis of Variance; Animals; Azepines; Blood Cell Count; Bone Marrow Transplantation; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Evans Blue; Hematocrit; Lung; Male; Mast Cells; Mice; Mice, Inbred AKR; Mice, Mutant Strains; Nedocromil; Permeability; Platelet Activating Factor; Prostaglandin D2; Species Specificity; Trachea; Triazoles | 1996 |
Role of platelet-activating factor in pathogenesis of galactosamine-lipopolysaccharide-induced liver injury.
Topics: Animals; Azepines; Cell Adhesion; Cells, Cultured; Chemical and Drug Induced Liver Injury; Endothelium; Escherichia coli; Galactosamine; Lipopolysaccharides; Liver; Male; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Triazoles; Tumor Necrosis Factor-alpha | 1996 |
Mutations of two adjacent amino acids generate inactive and constitutively active forms of the human platelet-activating factor receptor.
Topics: Amino Acid Sequence; Animals; Azepines; Base Sequence; Cells, Cultured; Chlorocebus aethiops; CHO Cells; Cricetinae; DNA Primers; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Membrane Glycoproteins; Molecular Sequence Data; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazoles | 1996 |
Mutation of an aspartate at position 63 in the human platelet-activating factor receptor augments binding affinity but abolishes G-protein-coupling and inositol phosphate production.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Azepines; Binding Sites; Binding, Competitive; Cell Line; Chlorocebus aethiops; CHO Cells; Conserved Sequence; Cricetinae; GTP-Binding Proteins; Inositol Phosphates; Kinetics; Mutagenesis, Site-Directed; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Point Mutation; Protein Conformation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Transfection; Triazoles | 1996 |
Augmentation of tumor metastasis by platelet-activating factor.
Topics: Animals; Antineoplastic Agents; Azepines; Female; Interleukin-1; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Platelet Activating Factor; Triazoles; Tumor Necrosis Factor-alpha | 1996 |
Ca2+ entry induced by calcium influx factor and its regulation by protein kinase C in rabbit neutrophils.
Topics: Adrenal Glands; Alkaloids; Animals; Azepines; Calcium; Calcium Channel Blockers; Cattle; Chromaffin Granules; Enzyme Inhibitors; Imidazoles; Ion Transport; Neutrophils; Platelet Activating Factor; Protein Kinase C; Rabbits; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Triazoles | 1996 |
Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi.
Topics: Animals; Azepines; Cell Differentiation; Kinetics; Microscopy, Electron; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles; Trypanosoma cruzi | 1996 |
Protective effect of a platelet-activating factor antagonist (WEB-2086) in postischemic renal failure.
Topics: Acute Kidney Injury; Animals; Azepines; Disease Models, Animal; Diuresis; Female; Ischemia; Kidney; Kidney Function Tests; Male; Necrosis; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Triazoles | 1996 |
Effect of pertussis toxin and B-oligomer on platelet-activating factor-induced generation of inositol phosphates in porcine alveolar macrophages.
Topics: Adenosine Diphosphate Ribose; Aluminum Chloride; Aluminum Compounds; Analysis of Variance; Animals; Azepines; Bronchoalveolar Lavage; Cell Survival; Cells, Cultured; Chlorides; GTP-Binding Proteins; Inositol; Inositol Phosphates; L-Lactate Dehydrogenase; Macrophages, Alveolar; NAD; Pertussis Toxin; Platelet Activating Factor; Platelet Aggregation Inhibitors; Random Allocation; Sodium Fluoride; Swine; Triazoles; Type C Phospholipases; Virulence Factors, Bordetella | 1996 |
Rapid tracheal infusion of surfactant versus bolus instillation in rabbits: effects on oxygenation, blood pressure and surfactant distribution.
Topics: Animals; Azepines; Blood Pressure; Lung; Oxygen; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Surface-Active Agents; Tissue Distribution; Trachea; Triazoles | 1996 |
Microvascular mechanisms of histamine-induced potentiation of leukocyte adhesion evoked by chemoattractants.
Topics: Amino Acid Sequence; Animals; Azepines; Chemotactic Factors; Drug Synergism; Female; Histamine; Leukocytes; Leukotriene B4; Microcirculation; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rats; Rats, Wistar; Splanchnic Circulation; Triazoles | 1995 |
Role for intracellular platelet-activating factor in the circulatory failure in a model of gram-positive shock.
Topics: Acute Kidney Injury; Animals; Azepines; Cells, Cultured; Diterpenes; Ginkgolides; Hemodynamics; Lactones; Lipopolysaccharides; Lung; Male; Nitric Oxide Synthase; Nitrites; Norepinephrine; Plant Extracts; Platelet Activating Factor; Rats; Rats, Wistar; Shock, Septic; Streptomyces; Teichoic Acids; Triazoles; Tumor Necrosis Factor-alpha | 1995 |
Platelet-activating factor and not thromboxane A2 is an important mediator of endotoxin-induced platelet aggregation in equine heparinised whole blood in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azepines; Carbazoles; Clonixin; Endotoxins; Heparin; Horses; In Vitro Techniques; Phospholipases A; Phospholipases A2; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinacrine; Thromboxane A2; Triazoles | 1996 |
Studies on the effects of agonists and antagonists on platelet shape change and platelet aggregation in whole blood.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Azepines; Blood Platelets; Humans; In Vitro Techniques; Piperazines; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Serotonin; Succinates; Sulfonamides; Thromboxane A2; Triazoles; Vasoconstrictor Agents | 1996 |
Decrease of ciliary beat frequency by platelet activating factor: protective effect of ketotifen.
Topics: Animals; Azepines; Dose-Response Relationship, Drug; Guinea Pigs; Histamine H1 Antagonists; Ketotifen; Mucociliary Clearance; Platelet Activating Factor; Platelet Aggregation Inhibitors; Trachea; Triazoles | 1996 |
Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero- 3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes.
Topics: Animals; Antineoplastic Agents; Astrocytes; Azepines; Cells, Cultured; Citrulline; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Immunohistochemistry; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Stimulation, Chemical; Thienopyridines; Triazoles | 1996 |
Prevention of platelet-activating factor-induced gastrointestinal lesions in rats by the new specific antagonist N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisopropylphe nyl) thiazol-2yl]amine.
Topics: Animals; Azepines; Dose-Response Relationship, Drug; Gastric Mucosa; Gastrointestinal Diseases; Intestinal Mucosa; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Thiazoles; Triazoles | 1996 |
Hypoxia induces PMN adherence to umbilical vein endothelium.
Topics: Antibodies, Monoclonal; Azepines; Cell Adhesion; Culture Techniques; Endothelium, Vascular; Humans; Hypoxia; Intercellular Adhesion Molecule-1; Microscopy, Electron, Scanning; Neutrophil Activation; Neutrophils; Oleic Acid; Oleic Acids; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Umbilical Veins | 1995 |
Priming of eosinophil recruitment in vivo by LPS pretreatment.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Azepines; CD18 Antigens; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Complement C5a, des-Arginine; Cycloheximide; Drug Synergism; Edema; Eosinophilia; Eosinophils; Female; Guinea Pigs; Immunoglobulin G; Interleukin 1 Receptor Antagonist Protein; Leukocyte Count; Leukotriene B4; Lipopolysaccharides; Lipoxygenase Inhibitors; Neutrophils; Passive Cutaneous Anaphylaxis; Platelet Activating Factor; Protein Synthesis Inhibitors; Pyrans; Quinolones; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Recombinant Fusion Proteins; Sialoglycoproteins; Skin; Triazoles; Zymosan | 1996 |
Platelet-activating factor is involved in the regulation of pathological leukocyte adhesion after liver transplantation.
Topics: Animals; Azepines; Cell Adhesion; Endothelium, Vascular; Female; Leukocyte Count; Leukocytes; Liver; Liver Circulation; Liver Transplantation; Microcirculation; Microscopy, Fluorescence; Platelet Activating Factor; Postoperative Complications; Rats; Rats, Sprague-Dawley; Transaminases; Triazoles | 1996 |
Helicobacter pylori stimulates gastric acid secretion via platelet activating factor.
Topics: Aminopyrine; Animals; Anti-Ulcer Agents; Azepines; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Male; Omeprazole; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Thienopyridines; Triazoles | 1996 |
Platelet-activating factor-induced inositol 1,4,5-trisphosphate generation in undifferentiated and differentiated U937 cells: role of tyrosine kinase.
Topics: Azepines; Blotting, Western; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Humans; Inositol 1,4,5-Trisphosphate; Isoflavones; Monocytes; Phosphorylation; Platelet Activating Factor; Protein-Tyrosine Kinases; Triazoles | 1996 |
Identification of transmembrane domain residues determinant in the structure-function relationship of the human platelet-activating factor receptor by site-directed mutagenesis.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Azepines; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein Conformation; Proto-Oncogene Proteins c-myc; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Transfection; Triazoles | 1996 |
Platelet-activating factor modulates leukocyte adhesion to endothelium in ischemia-reperfusion.
Topics: Animals; Azepines; Cell Adhesion; Cheek; Cricetinae; Endothelium, Vascular; Leukocytes; Male; Mesocricetus; Mouth Mucosa; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reperfusion Injury; Triazoles | 1996 |
Platelet-activating factor enhances urokinase-type plasminogen activator gene expression in corneal epithelium.
Topics: Amanitins; Animals; Azepines; Blotting, Northern; Cornea; Cyclic AMP; Dactinomycin; Epithelium; Ethers, Cyclic; Gene Expression Regulation, Enzymologic; GTP-Binding Proteins; Okadaic Acid; Organ Culture Techniques; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Synthesis Inhibitors; Rabbits; RNA, Messenger; Thienopyridines; Transcription, Genetic; Transcriptional Activation; Triazoles; Urokinase-Type Plasminogen Activator | 1996 |
Eosinophil migration in response to three molecular species of platelet activating factor.
Topics: Adult; Azepines; Cell Movement; Cell Separation; Chemotaxis; Eosinophils; Humans; Platelet Activating Factor; Platelet Aggregation Inhibitors; Polycarboxylate Cement; Porosity; Structure-Activity Relationship; Triazoles | 1996 |
Anti-inflammatory effect of a PAF receptor antagonist and a new molecule with antiproteinase activity in an experimental model of acute urate crystal arthritis.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Azepines; C-Reactive Protein; Dinoprostone; Disease Models, Animal; Indenes; Interleukin-6; Joints; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protease Inhibitors; Rabbits; Random Allocation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Synovial Fluid; Thienopyridines; Triazoles; Tumor Necrosis Factor-alpha; Uric Acid | 1996 |
Role of platelet-activating factor and thromboxane A2 in radical production during ischemia and reperfusion of the rat brain.
Topics: Animals; Ascorbic Acid; Azepines; Brain; Brain Ischemia; Bridged Bicyclo Compounds; Dehydroascorbic Acid; Extracellular Space; Fatty Acids, Monounsaturated; Free Radicals; Male; Oxygen; Partial Pressure; Peroxidase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion; Thromboxane A2; Triazoles | 1996 |
Effect of locally applied WEB 2086, a platelet-activating factor antagonist, on inflammatory skin conditions in mice.
Topics: Animals; Azepines; Dermatitis, Allergic Contact; Gels; Mice; Mice, Inbred Strains; Platelet Activating Factor; Radiodermatitis; Triazoles; Ultraviolet Rays | 1996 |
Protective effect of platelet activating factor antagonists on cultured endothelial cell lysis induced by elastase or activated neutrophils.
Topics: Azepines; Cells, Cultured; Diterpenes; Dose-Response Relationship, Drug; Endothelium, Vascular; Ginkgolides; Humans; Lactones; Leukocyte Elastase; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles | 1996 |
Pharmacological evidence of a role for platelet activating factor as a modulator of vasomotor tone and blood pressure.
Topics: Animals; Azepines; Blood Pressure; Carotid Arteries; Diterpenes; Enzyme Inhibitors; Female; Ginkgolides; Glutamic Acid; Injections, Intraventricular; Lactones; Male; Muscle Tonus; Norepinephrine; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Membrane Glycoproteins; Quinacrine; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1996 |
Guanine nucleotide regulatory proteins, Gq and Gi1/2, mediate platelet-activating factor-stimulated phosphoinositide metabolism in immortalized hippocampal cells.
Topics: Animals; Azepines; Cell Line, Transformed; Cell Membrane; GTP-Binding Proteins; Guanosine Triphosphate; Hippocampus; Hybrid Cells; Immune Sera; Mice; Mice, Inbred C57BL; Neuroblastoma; Neurons; Pertussis Toxin; Phosphatidylinositols; Platelet Activating Factor; Triazoles; Virulence Factors, Bordetella | 1996 |
Induction of IL-4 by platelet-activating factor.
Topics: Antibodies, Monoclonal; Azepines; Cells, Cultured; Histocompatibility Antigens Class II; Humans; Immunoglobulin A; Interleukin-4; Interleukin-6; Leukocytes, Mononuclear; Lymphocyte Activation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1996 |
Characterization of [3H]apafant binding to PAF receptor on rabbit platelet membranes: a comparison of a microplate filtration system and a standard method.
Topics: Animals; Azepines; Binding, Competitive; Blood Platelets; Filtration; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1996 |
Effects of platelet activating factor on the distribution of radiolabelled leucocytes and platelets in normal horses and asymptomatic horses with chronic obstructive pulmonary disease.
Topics: Analysis of Variance; Animals; Azepines; Blood Platelets; Eosinophils; Heart Rate; Horse Diseases; Horses; Indium Radioisotopes; Leukocyte Count; Lung Diseases, Obstructive; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pleura; Pressure; Reference Values; Respiration; Respiratory Function Tests; Time Factors; Triazoles | 1996 |
Escherichia coli hemolysin and Staphylococcus aureas alpha-toxin potently induce neutrophil adhesion to cultured human endothelial cells.
Topics: Azepines; Bacterial Proteins; Bacterial Toxins; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Endothelium, Vascular; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation; Hemolysin Proteins; Humans; Macrophage-1 Antigen; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staphylococcus aureus; Thienopyridines; Triazoles; Umbilical Veins | 1996 |
Involvement of PAF in postallergic propranolol-induced bronchoconstriction in guinea-pigs.
Topics: Administration, Inhalation; Adrenergic beta-Antagonists; Anesthesia, General; Animals; Antigens; Asthma; Azepines; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Hypersensitivity; Immunization; Inflammation Mediators; Injections, Intravenous; Male; Platelet Activating Factor; Propranolol; Respiration, Artificial; Time Factors; Triazoles | 1996 |
Inhibition of PAF-induced platelet aggregation by WEB 2086 'in-vitro', an antagonist to the receptor for platelet-activating factor, in bovine.
Topics: Animals; Azepines; Blood Platelets; Cattle; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Microscopy, Electron; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1996 |
Plasmin promotes an endothelium-dependent adhesion of neutrophils. Involvement of platelet activating factor and P-selectin.
Topics: Animals; Antibodies; Antibodies, Monoclonal; Azepines; Capillary Permeability; Cattle; CD18 Antigens; Cell Adhesion; Endothelium, Vascular; Fibrinolysin; Humans; Neutrophils; P-Selectin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Streptokinase; Tissue Plasminogen Activator; Triazoles | 1996 |
The effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and its analogues platelet activating factor and carbamyl-platelet activating factor on the biosynthesis of interleukin-6 in human thymic epithelial cells cultivated in vitro
Topics: Azepines; Cells, Cultured; Dose-Response Relationship, Drug; Epithelium; Humans; Interleukin-6; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Thymus Gland; Triazoles | 1996 |
Demonstration of reversible priming of human neutrophils using platelet-activating factor.
Topics: Adult; Azepines; Cell Adhesion; Cell Polarity; Cell Size; Cells, Cultured; Dihydropyridines; Enzyme Activation; Humans; Imidazoles; Macrophage-1 Antigen; Microspheres; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Burst; Superoxides; Time Factors; Triazoles; Tumor Necrosis Factor-alpha | 1996 |
Effect of Y-24180, a platelet-activating factor-receptor antagonist, on the antigen-induced airway microvascular leakage in guinea pigs.
Topics: Animals; Antigens; Azepines; Bronchi; Capillary Permeability; Dose-Response Relationship, Drug; Guinea Pigs; Linear Models; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Trachea; Triazoles | 1996 |
Effect of BN 50727 on pathological findings and tissue platelet activating factor levels during ileal ischemia in newborn piglets.
Topics: Animals; Animals, Newborn; Azepines; Disease Models, Animal; Enterocolitis, Pseudomembranous; Humans; Ileum; Infant, Newborn; Ischemia; Platelet Activating Factor; Swine; Thienopyridines; Triazoles; Tumor Necrosis Factor-alpha | 1996 |
Different classes of PAF-antagonists block norepinephrine-induced vascular escape and tachyphylaxis in the isolated rabbit kidney.
Topics: Animals; Azepines; Dihydropyridines; Ginkgolides; In Vitro Techniques; Kidney; Lactones; Norepinephrine; Platelet Activating Factor; Rabbits; Tachyphylaxis; Triazoles; Vasoconstriction | 1996 |
Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF).
Topics: Administration, Oral; Animals; Azepines; Blood Pressure; Cyproheptadine; Dogs; Guinea Pigs; Histamine Antagonists; Male; Mice; Motor Activity; Platelet Activating Factor; Platelet Aggregation; Pyrilamine; Rabbits; Rats; Rats, Sprague-Dawley; Triazoles | 1997 |
Augmented expression of platelet-activating factor receptor gene by TNF-alpha through transcriptional activation in human monocytes.
Topics: Azepines; Half-Life; Humans; Interleukin-6; Monocytes; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Transcriptional Activation; Triazoles; Tumor Necrosis Factor-alpha; Up-Regulation | 1997 |
Angiogenesis induced in vivo by hepatocyte growth factor is mediated by platelet-activating factor synthesis from macrophages.
Topics: Animals; Azepines; Cattle; Cell Movement; Cells, Cultured; Chemotaxis, Leukocyte; Collagen; Drug Combinations; Hepatocyte Growth Factor; Humans; Laminin; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Phosphotyrosine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteoglycans; Proto-Oncogene Mas; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles | 1997 |
Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor.
Topics: Amino Acid Sequence; Animals; Azepines; Binding, Competitive; CHO Cells; COS Cells; Cricetinae; Cysteine; Dithiothreitol; DNA Primers; Humans; Inositol Phosphates; Kinetics; Models, Structural; Mutagenesis, Site-Directed; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Protein Structure, Secondary; Proto-Oncogene Proteins c-myc; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Transfection; Triazoles | 1997 |
Effects of Y-24180, a long-acting and potent antagonist to platelet-activating factor, on immediate asthmatic response in guinea pigs.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Azepines; Benzoquinones; Bronchodilator Agents; Chromones; Drug Interactions; Drug Therapy, Combination; Guinea Pigs; Heptanoic Acids; Male; Methacrylates; Platelet Activating Factor; Theophylline; Triazoles | 1997 |
Up-regulation of the intracellular Ca2+ signaling and mRNA expression of platelet-activating factor receptor by estradiol in human uterine endometrial cells.
Topics: Alternative Splicing; Azepines; Calcium; Cells, Cultured; Endometrium; Estradiol; Female; Gene Expression; Humans; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; Stromal Cells; Triazoles; Up-Regulation | 1996 |
Role of platelet-activating factor in skeletal muscle ischemia-reperfusion injury.
Topics: Animals; Azepines; Dogs; Female; Heart Rate; In Vitro Techniques; Ischemia; Muscle, Skeletal; Necrosis; Platelet Activating Factor; Platelet Aggregation Inhibitors; Reperfusion Injury; Triazoles | 1996 |
Platelet-activating factor. A possible role in the modulation of the vasomotor tone and blood pressure.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Blood Pressure; Carotid Arteries; Diterpenes; Enzyme Inhibitors; Ginkgolides; Indomethacin; Lactones; Muscle Tonus; Muscle, Smooth, Vascular; Norepinephrine; Phospholipases A; Platelet Activating Factor; Platelet Aggregation Inhibitors; Quinacrine; Rabbits; Triazoles | 1996 |
Non-specific PAF binding to embryonal F9 cells and prostacyclin synthesis in human umbilical vein endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Carcinoma, Embryonal; Cell Line; Embryo, Mammalian; Endothelium, Vascular; Epoprostenol; Humans; Mice; Neoplasms, Germ Cell and Embryonal; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles; Umbilical Veins | 1996 |
A mitogen-activated protein kinase (MAP-kinase) cascade is stimulated by platelet activating factor (PAF) in corneal epithelium.
Topics: Animals; Azepines; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, DEAE-Cellulose; Cornea; Enzyme Activation; Epithelium; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rabbits; Stimulation, Chemical; Thienopyridines; Triazoles | 1997 |
The platelet-activating factor receptor antagonist WEB 2170 prevents neonatal necrotizing enterocolitis in rats.
Topics: Animals; Animals, Newborn; Azepines; Enterocolitis, Pseudomembranous; Intestinal Mucosa; Intestine, Small; Necrosis; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1997 |
Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock.
Topics: Animals; Azepines; Blood Gas Analysis; Fluid Therapy; Hemodynamics; Lipopolysaccharides; Platelet Activating Factor; Platelet Aggregation Inhibitors; Resuscitation; Shock, Traumatic; Swine; Triazoles | 1997 |
Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking.
Topics: Animals; Antioxidants; Ascorbic Acid; Azepines; Blood Platelets; Cell Adhesion; Cell Aggregation; Chemokine CCL4; Cricetinae; Humans; Interleukin-8; Macrophage Inflammatory Proteins; Monocytes; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reference Values; Smoking; Time Factors; Triazoles | 1997 |
Platelet-activating factor and oxidized LDL induce immune activation by a common mechanism.
Topics: Azepines; Humans; Immunity; Interferon-gamma; Leukocytes, Mononuclear; Lipoproteins, LDL; Oxidation-Reduction; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Tumor Necrosis Factor-alpha | 1997 |
Species differences in PAF receptor binding in the lungs between hamster and guinea pig.
Topics: Animals; Azepines; Binding, Competitive; Cricetinae; Fibrinolytic Agents; Guinea Pigs; Kinetics; Ligands; Lung; Male; Mesocricetus; Organophosphorus Compounds; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Species Specificity; Thiazoles; Triazoles | 1997 |
PAF antagonists as possible inhibitors of corneal epithelial defects and ulceration.
Topics: Azepines; Cornea; Corneal Injuries; Diterpenes; Enzyme Activation; Epithelium; Extracellular Matrix Proteins; Fibrinolytic Agents; Ginkgolides; Lactones; Metalloendopeptidases; Phospholipid Ethers; Platelet Activating Factor; Thienopyridines; Triazoles; Urokinase-Type Plasminogen Activator; Wound Healing | 1997 |
Platelet-activating factor stimulates interleukin-6 production by human endothelial cells and synergizes with tumor necrosis factor for enhanced production of granulocyte-macrophage colony stimulating factor.
Topics: Azepines; Drug Synergism; Endothelium, Vascular; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation; Inflammation Mediators; Interleukin-6; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Triazoles; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
Studies of the nature of the binding by albumin of platelet-activating factor released from cells.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Azepines; Biological Availability; Blastocyst; Calcimycin; Cattle; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Humans; Ionophores; Mice; Pepsin A; Peptide Mapping; Phospholipases A; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Binding; Protein Conformation; Serum Albumin; Serum Albumin, Bovine; Sulfhydryl Reagents; Triazoles; Trypsin | 1997 |
Neither platelet activating factor nor leukotrienes are critical mediators of liver injury after lipopolysaccharide administration.
Topics: Administration, Oral; Alanine Transaminase; Animals; Azepines; Blood Platelets; Chemical and Drug Induced Liver Injury; Female; Fibrinogen; Hydroxyurea; Injections, Intraperitoneal; Injections, Intravenous; Leukotrienes; Lipopolysaccharides; Lipoxygenase Inhibitors; Liver; Liver Diseases; Necrosis; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thrombocytopenia; Triazoles | 1997 |
Dissociation of TNF-alpha from endotoxin-induced nitric oxide and acute-phase hypotension.
Topics: Animals; Azepines; Blood Pressure; Endotoxins; Enzyme Induction; Escherichia coli; Heart Rate; Hypotension; Immunoglobulin G; Lipopolysaccharides; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thienopyridines; Time Factors; Transcription, Genetic; Triazoles; Tumor Necrosis Factor-alpha | 1997 |
Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha.
Topics: Animals; Azepines; Cell Movement; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Platelet Activating Factor; Triazoles; Tumor Necrosis Factor-alpha | 1997 |
Structural and functional requirements for agonist-induced internalization of the human platelet-activating factor receptor.
Topics: Animals; Azepines; Cell Compartmentation; CHO Cells; COS Cells; Cricetinae; Endocytosis; GTP-Binding Proteins; Humans; Inositol Phosphates; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Transfection; Triazoles | 1997 |
Modulation of endotoxin-induced inflammation in the bovine teat using antagonists/inhibitors to leukotrienes, platelet activating factor and interleukin 1 beta.
Topics: Adjuvants, Immunologic; Animals; Azepines; Blood Coagulation Factors; Cattle; Endotoxins; Female; Fibrinolytic Agents; Humans; Indoles; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Leukotriene Antagonists; Lipoxygenase Inhibitors; Mammary Glands, Animal; Mastitis, Bovine; Platelet Activating Factor; Platelet Aggregation Inhibitors; Recombinant Proteins; Sialoglycoproteins; Triazoles | 1997 |
Human monocytes maintained in culture acquire functional responsiveness to platelet-activating factor that is independent of increases in protein tyrosine phosphorylation.
Topics: Azepines; Calcium; Cells, Cultured; Humans; Monocytes; Oxygen; Phosphorylation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles; Tyrosine | 1997 |
Hyperglycemic damage to mitochondrial membranes during cerebral ischemia: amelioration by platelet-activating factor antagonist BN 50739.
Topics: Animals; Azepines; Blood Pressure; Brain; Disease Models, Animal; Electroencephalography; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Femoral Artery; Hyperglycemia; Intracellular Membranes; Ischemic Attack, Transient; Lipid Peroxidation; Male; Membrane Lipids; Mitochondria; Oxygen Consumption; Phospholipids; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reference Values; Reperfusion; Thiobarbituric Acid Reactive Substances; Time Factors; Triazoles | 1997 |
Combined effect of Web 2086 (Paf antagonist) and ketoprofen (Nsaid) on Paf-induced ex vivo platelet aggregation in bovine.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Cattle; Dose-Response Relationship, Drug; Drug Synergism; Infusions, Intravenous; Ketoprofen; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Time Factors; Triazoles | 1997 |
Effect of platelet-activating factor on bovine pulmonary function.
Topics: Animals; Azepines; Cattle; Heart Rate; Lung; Lung Compliance; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Respiration; Respiratory Function Tests; Respiratory Mechanics; Tidal Volume; Triazoles | 1997 |
Platelet-activating factor mediates angiotensin II-induced proteinuria in isolated perfused rat kidney.
Topics: Angiotensin II; Animals; Azepines; Dexamethasone; Glucocorticoids; In Vitro Techniques; Kidney; Male; Perfusion; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Proteinuria; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1997 |
cAMP mediates homologous downregulation of PAF receptor mRNA expression in mesangial cells.
Topics: Animals; Azepines; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Down-Regulation; Female; Glomerular Mesangium; Indomethacin; Kinetics; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; Transcription, Genetic; Triazoles; Virulence Factors, Bordetella | 1997 |
A simple, rapid and specific radioreceptor assay for platelet-activating factor.
Topics: Animals; Azepines; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Humans; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Substrate Specificity; Triazoles | 1997 |
The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves.
Topics: Animals; Azepines; Cattle; Chromatography, High Pressure Liquid; Infusions, Intravenous; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Time Factors; Triazoles | 1997 |
Eosinophil chemotaxis induced by several biologically active substances and the effects of apafant on it in vitro.
Topics: Animals; Azepines; Bronchoalveolar Lavage Fluid; Chemotaxis; Eosinophils; Guinea Pigs; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles | 1997 |
Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes.
Topics: Animals; Azepines; Bronchi; Bronchial Hyperreactivity; Chromones; Indoles; Indomethacin; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Lung; Methacrylates; Mice; Mice, Transgenic; Phenylpropionates; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Leukotriene B4; Thromboxanes; Triazoles | 1997 |
Platelet-activating factor induces cyclooxygenase-2 gene expression in corneal epithelium. Requirement of calcium in the signal transduction pathway.
Topics: Aniline Compounds; Animals; Azepines; Blotting, Northern; Blotting, Western; Calcimycin; Calcium; Cyclooxygenase 2; Enzyme Induction; Epithelium, Corneal; Fluorescent Dyes; Gene Expression; Ionophores; Isoenzymes; Microscopy, Confocal; Organ Culture Techniques; Peroxidases; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rabbits; RNA, Messenger; Signal Transduction; Thienopyridines; Triazoles; Xanthenes | 1997 |
Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action.
Topics: Acetylcholine; Administration, Oral; Animals; Azepines; Binding Sites; Blood Platelets; Bradykinin; Bronchial Hyperreactivity; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Injections, Intravenous; Leukotriene D4; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin; Structure-Activity Relationship; Triazoles | 1997 |
[A study on changes and its mechanisms of intestinal mucosal permeability after severe burn].
Topics: Animals; Azepines; Burns; Female; Intestinal Mucosa; Male; Permeability; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Technetium Tc 99m Pentetate; Triazoles | 1996 |
Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkylating Agents; Animals; Azepines; Bronchitis; Capillary Permeability; Coloring Agents; Disease Models, Animal; Drug Interactions; Evans Blue; Indazoles; Leukotrienes; Male; Mechlorethamine; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rabbits; Reference Values; Trachea; Triazoles; Vasoconstrictor Agents | 1997 |
Lung oedema induced by Tityus serrulatus scorpion venom in the rat.
Topics: Animals; Aprotinin; Azepines; Capillary Permeability; Cyclooxygenase Inhibitors; Diterpenes; Drug Interactions; Fibrinolytic Agents; Ginkgolides; Hemostatics; Heparin; Hypertension; Injections, Intravenous; Lactones; Leukotrienes; Lipoxygenase Inhibitors; Lung; Male; Masoprocol; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandins; Pulmonary Edema; Rats; Rats, Wistar; Scorpion Venoms; Triazoles | 1997 |
Effects of apafant on PAF-induced downregulation of beta-adrenoceptors in guinea pigs.
Topics: Adrenergic beta-Agonists; Animals; Azepines; Binding, Competitive; Bronchi; Down-Regulation; Guinea Pigs; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth; Platelet Activating Factor; Platelet Aggregation Inhibitors; Receptors, Adrenergic, beta; Triazoles | 1997 |
Inhibitor effect of apafant on bronchopulmonary responses to platelet activating factor and to antigen in rats.
Topics: Animals; Azepines; Bronchi; Histamine; Hypersensitivity, Immediate; In Vitro Techniques; Lung; Male; Organ Size; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pulmonary Circulation; Rats; Rats, Inbred BN; Rats, Wistar; Triazoles | 1997 |
Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets.
Topics: Animals; Azepines; Blood Platelets; Humans; In Vitro Techniques; Kinetics; Neutrophils; P-Selectin; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines; Triazoles | 1998 |
Possible mechanism of alprazolam-induced amnesia in mice.
Topics: Alprazolam; Amnesia; Animals; Azepines; Drug Evaluation, Preclinical; Female; Flumazenil; GABA Agonists; Male; Maze Learning; Mice; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles | 1998 |
Platelet-activating factor mediates monocyte chemoattractant protein-1 expression in glomerular immune injury.
Topics: Animals; Azepines; Chemokine CCL2; Complement System Proteins; Glomerulonephritis; Kidney Glomerulus; Male; Platelet Activating Factor; Polymerase Chain Reaction; Rabbits; Rats; Rats, Wistar; RNA, Messenger; Triazoles | 1998 |
Investigation of the effects of platelet-activating factor (PAF) on ion transport and prostaglandin synthesis in human colonic mucosa in vitro.
Topics: Azepines; Biological Transport; Colon; Humans; Intestinal Mucosa; Ions; Membrane Potentials; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prostaglandins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1998 |
Involvement of platelet-activating factor in cell death induced under ischemia/postischemia-like conditions in an immortalized hippocampal cell line.
Topics: Azepines; Calcium; Cell Death; Cell Line, Transformed; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Ischemia; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reperfusion Injury; Signal Transduction; Triazoles | 1998 |
PAF-induced secretory hyperresponsiveness in the ferret trachea to bradykinin and its pharmacological inhibition.
Topics: Albumins; Animals; Anti-Asthmatic Agents; Azepines; Bradykinin; Drug Interactions; Female; Ferrets; Male; Muramidase; Nedocromil; Platelet Activating Factor; Platelet Aggregation Inhibitors; Trachea; Triazoles | 1997 |
The acute increases in vasomotor tone and blood pressure induced by carotid artery occlusion are modulated by platelet-activating factor (PAF) independently of nitric oxide release.
Topics: Animals; Azepines; Blood Pressure; Cardiac Output; Carotid Arteries; Carotid Stenosis; Enzyme Inhibitors; Feedback; Female; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pressoreceptors; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles; Vascular Resistance; Vasoconstriction | 1997 |
Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla.
Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Animals; Azepines; Biphenyl Compounds; Chinchilla; Dinoprostone; Ear, Middle; Fatty Acids, Nonesterified; Heptanoic Acids; Hydrolases; Leukotriene Antagonists; Leukotriene C4; Mucous Membrane; Otitis Media; Phospholipids; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pneumococcal Infections; Propionates; Quinolines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Thromboxane; Thromboxane B2; Triazoles | 1998 |
High and low affinity mutants of platelet-activating factor receptor.
Topics: Amino Acid Sequence; Animals; Azepines; COS Cells; Guinea Pigs; Kinetics; Mutagenesis, Site-Directed; Oligopeptides; Peptides; Platelet Activating Factor; Platelet Membrane Glycoproteins; Point Mutation; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Transfection; Triazoles; Tritium | 1997 |
Effects of platelet-activating factor on intracellular Ca2+ concentration and contractility in isolated cardiomyocytes.
Topics: Analysis of Variance; Animals; Azepines; Calcium; Male; Myocardial Contraction; Myocardium; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Triazoles | 1998 |
Inhibition of tumor necrosis factor-alpha production by SK&F 98625, a CoA-independent transacylase inhibitor, in cultured rat peritoneal macrophages.
Topics: Acyltransferases; Animals; Azepines; Cells, Cultured; Dinoprostone; Enzyme Inhibitors; Furans; Imidazoles; Macrophages, Peritoneal; Male; Organophosphorus Compounds; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Thapsigargin; Triazoles; Tumor Necrosis Factor-alpha | 1998 |
Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion.
Topics: Androstadienes; Animals; Azepines; Cell Adhesion Molecules; Cell Movement; Chromones; Colonic Neoplasms; Dogs; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Genes, src; GTP-Binding Proteins; Hepatocyte Growth Factor; Humans; Intestinal Mucosa; Kidney; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Thiazoles; Transformation, Genetic; Triazoles; Tumor Cells, Cultured; Virulence Factors, Bordetella; Wortmannin | 1998 |
The role of platelet-activating factor in cell infiltration in endotoxin-induced uveitis in guinea pigs.
Topics: Animals; Anterior Chamber; Aqueous Humor; Azepines; Betamethasone; Chemotaxis, Leukocyte; Dinoprostone; Escherichia coli; Flow Cytometry; Guinea Pigs; Indomethacin; Leukocyte Count; Leukocytes; Lipopolysaccharides; Male; Ophthalmic Solutions; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles; Uveitis, Anterior | 1998 |
In situ expression of platelet-activating factor (PAF)-receptor gene in rat skin and effects of PAF on proliferation and differentiation of cultured human keratinocytes.
Topics: Animals; Azepines; Cell Differentiation; Cell Division; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Fibrinolytic Agents; Gene Expression; Genes; Humans; In Situ Hybridization; Keratinocytes; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Skin; Transcription, Genetic; Triazoles | 1998 |
Inhibition of Na+,K(+)-ATPase by platelet-activating factor in dog submandibular glands.
Topics: Animals; Azepines; Binding Sites; Dogs; Membrane Proteins; Mucins; Ouabain; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sodium-Potassium-Exchanging ATPase; Subcellular Fractions; Submandibular Gland; Triazoles | 1998 |
Protective effects of WEB 2086 (PAF antagonist) and ketoprofen (NSAID) on PAF-induced changes in the morphological ultrastructure of blood platelets in calves.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Blood Platelets; Cattle; Golgi Apparatus; Ketoprofen; Male; Microscopy, Electron; Microtubules; Mitochondria; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Count; Reference Values; Triazoles | 1998 |
Platelet-activating factor is a downstream messenger of kainate-induced activation of mitogen-activated protein kinases in primary hippocampal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Astrocytes; Azepines; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; Enzyme Activation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; JNK Mitogen-Activated Protein Kinases; Kainic Acid; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuronal Plasticity; Neurons; p38 Mitogen-Activated Protein Kinases; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein Kinases; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles | 1998 |
Tumour necrosis factor-alpha induces hyperreactivity in tracheal smooth muscle of the guinea-pig in vitro.
Topics: Airway Resistance; Animals; Azepines; Bronchial Hyperreactivity; Culture Techniques; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Muscle, Smooth; Platelet Activating Factor; Platelet Aggregation Inhibitors; Recombinant Proteins; Triazoles; Tumor Necrosis Factor-alpha | 1998 |
PAF and CD18 mediate neutrophil infiltration in upper gastrointestinal tract during intra-abdominal sepsis.
Topics: Abdomen; Animals; Antibodies, Monoclonal; Azepines; Blood Pressure; CD18 Antigens; Cecum; Hematocrit; Intercellular Adhesion Molecule-1; Intestines; Leukocyte Count; Male; Neutrophils; Peroxidase; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Sepsis; Triazoles | 1998 |
Eosinophilic airway inflammation induced by repeated exposure to cigarette smoke.
Topics: Animals; Azepines; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Guinea Pigs; Male; Nicotiana; Plants, Toxic; Platelet Activating Factor; Pulmonary Eosinophilia; Smoke; Time Factors; Triazoles | 1998 |
Platelet-activating factor modulates pulmonary vasomotor tone in the perinatal lamb.
Topics: Angiotensin II; Animals; Animals, Newborn; Azepines; Blood Pressure; Female; Muscle Tonus; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pregnancy; Pulmonary Circulation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sheep; Triazoles; Vascular Resistance; Vasoconstrictor Agents | 1998 |
Triple role of platelet-activating factor in eosinophil migration across monolayers of lung epithelial cells: eosinophil chemoattractant and priming agent and epithelial cell activator.
Topics: Adjuvants, Immunologic; Azepines; Cell Culture Techniques; Cell Line; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Drug Synergism; Eosinophils; Epithelial Cells; Humans; Immunization; Leukocyte Count; Lung; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Tumor Cells, Cultured | 1998 |
Effects of WEB 2086 on the protective role of preconditioning against arrhythmias in rats.
Topics: Animals; Arrhythmias, Cardiac; Azepines; Hemodynamics; Ischemic Preconditioning; Male; Platelet Activating Factor; Rats; Triazoles | 1998 |
Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice.
Topics: Anaphylaxis; Animals; Antibodies, Monoclonal; Azepines; Female; Haptens; Histamine; Immunoglobulin E; Interleukin-4; Mast Cells; Mice; Mice, Mutant Strains; Penicillin V; Platelet Activating Factor; Triazoles | 1998 |
Modulation by lipid mediators of immune complex-induced lung inflammation in mice.
Topics: Animals; Antigen-Antibody Complex; Arthus Reaction; Azepines; Benzopyrans; Blood Vessels; Bronchoalveolar Lavage Fluid; Capillary Permeability; Dose-Response Relationship, Drug; Eicosanoids; Hemoglobins; Immune Complex Diseases; Indoles; Indomethacin; Lipoxygenase Inhibitors; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neutrophils; Peroxidase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pneumonia; Receptors, Leukotriene B4; Species Specificity; Triazoles | 1998 |
Xenogeneic rejection mechanisms shown by intravital microscopy.
Topics: Animals; Azepines; Bile; Blood Pressure; Blood Transfusion; Elapid Venoms; Graft Rejection; Humans; Liver Circulation; Microcirculation; Microscopy, Fluorescence; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Transplantation, Heterologous; Transplantation, Isogeneic; Triazoles | 1998 |
Effect of Y-24180, an antagonist at platelet-activating factor (PAF) receptors, on IgE-mediated cutaneous reactions in mice.
Topics: Animals; Azepines; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Ear; Eosinophils; Female; Immunoglobulin E; Kinetics; Macrophages; Mice; Mice, Inbred BALB C; Monocytes; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prednisolone; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1998 |
Interleukin-12 is synthesized by mesangial cells and stimulates platelet-activating factor synthesis, cytoskeletal reorganization, and cell shape change.
Topics: Angiotensin II; Azepines; Cell Size; Cells, Cultured; Cytoskeleton; Dose-Response Relationship, Drug; Glomerular Mesangium; Humans; Interleukin-12; Interleukin-8; Lipopolysaccharides; Platelet Activating Factor; Platelet Aggregation Inhibitors; Receptors, Interleukin; Receptors, Interleukin-12; RNA, Messenger; Superoxides; Time Factors; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Glutamate receptor signaling interplay modulates stress-sensitive mitogen-activated protein kinases and neuronal cell death.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Azepines; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Hippocampus; Neurons; Phospholipases A; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Second Messenger Systems; Signal Transduction; Thienopyridines; Triazoles | 1999 |
Intracellular mechanisms of hydrogen peroxide-mediated neutrophil adherence to cultured human endothelial cells.
Topics: Azepines; Calcimycin; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hydrogen Peroxide; In Vitro Techniques; Neutrophils; P-Selectin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase Inhibitors; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Second Messenger Systems; Tetradecanoylphorbol Acetate; Triazoles | 1999 |
Influence of platelet-activating factor on cerebral microcirculation in rats: part 1. Systemic application.
Topics: Animals; Azepines; Blood Pressure; Blood-Brain Barrier; Carbon Dioxide; Cell Communication; Cerebrovascular Circulation; Endothelium, Vascular; Hematocrit; Hydrogen-Ion Concentration; Leukocyte Count; Leukocytes; Male; Microcirculation; Microscopy, Fluorescence; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Triazoles | 1999 |
Influence of platelet-activating factor on cerebral microcirculation in rats: part 2. Local application.
Topics: Animals; Azepines; Blood Pressure; Blood-Brain Barrier; Cell Communication; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Endothelium, Vascular; Leukocytes; Male; Microcirculation; Microscopy, Fluorescence; Pia Mater; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Triazoles | 1999 |
Effects of Y-24180, a receptor antagonist to platelet-activating factor, on allergic cutaneous eosinophilia in mice.
Topics: Animals; Azepines; Cytokines; Eosinophilia; Hypersensitivity; Male; Mice; Mice, Inbred BALB C; Platelet Activating Factor; Skin Diseases; Triazoles | 1999 |
Thrombopoietin stimulates endothelial cell motility and neoangiogenesis by a platelet-activating factor-dependent mechanism.
Topics: Animals; Azepines; Biocompatible Materials; Biological Transport; Cell Division; Cell Movement; Cell Nucleus; Cells, Cultured; Collagen; DNA-Binding Proteins; Drug Combinations; Endothelium, Vascular; Fibroblast Growth Factor 2; Gene Expression; Humans; Interleukin-8; Kinetics; Laminin; Mice; Milk Proteins; Neoplasm Proteins; Neovascularization, Physiologic; Phosphorylation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Proteoglycans; Proto-Oncogene Proteins; Receptors, Cytokine; Receptors, Thrombopoietin; Signal Transduction; STAT1 Transcription Factor; STAT5 Transcription Factor; Thrombopoietin; Trans-Activators; Triazoles; Tyrosine; Umbilical Veins | 1999 |
Effect of platelet activating factor and its antagonist on the mucociliary clearance of the eustachian tube in guinea pigs.
Topics: Animals; Azepines; Cilia; Coloring Agents; Dose-Response Relationship, Drug; Epithelium; Eustachian Tube; Guinea Pigs; Microscopy, Electron; Mucociliary Clearance; Otitis Media with Effusion; Platelet Activating Factor; Rosaniline Dyes; Triazoles | 1999 |
The synthesis of platelet-activating factor modulates chemotaxis of monocytes induced by HIV-1 Tat.
Topics: Azepines; Chemotaxis; Gene Products, tat; HIV-1; Humans; Monocytes; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; tat Gene Products, Human Immunodeficiency Virus; Triazoles | 1999 |
Captopril and platelet-activating factor (PAF) antagonist prevent cardiac allograft vasculopathy in rats: role of endogenous PAF and PAF-like compounds.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Azepines; Captopril; Coronary Disease; Disease Models, Animal; Drug Therapy, Combination; Heart Transplantation; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Random Allocation; Rats; Rats, Inbred F344; Rats, Inbred Lew; Transplantation, Homologous; Treatment Outcome; Triazoles; Ventricular Remodeling | 1999 |
Mechanisms of interaction of a plasmalogenic analog of platelet-activating factor with human platelets.
Topics: Adenylyl Cyclase Inhibitors; Alprostadil; Azepines; Blood Platelets; Calcium; Dose-Response Relationship, Drug; Humans; Kinetics; Plasmalogens; Platelet Activating Factor; Triazoles | 1999 |
Possible participation of intracellular platelet-activating factor in tumor necrosis factor-alpha production by rat peritoneal macrophages.
Topics: Animals; Azepines; Cells, Cultured; Dinoprostone; Enzyme Inhibitors; Furans; Imidazoles; Indomethacin; Macrophages, Peritoneal; Male; Organophosphorus Compounds; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thapsigargin; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Role of thromboxane A2 and platelet activating factor in early haemodynamic response to lipopolysaccharide in rats.
Topics: Animals; Azepines; Blood Pressure; Enzyme Inhibitors; Escherichia coli; Indans; Lipopolysaccharides; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thromboxane A2; Triazoles | 1999 |
Proposal of a new PAF pharmacophoric map by the AM1 method.
Topics: Azepines; Models, Molecular; Molecular Conformation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Quantum Theory; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazoles | 1999 |
HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity.
Topics: Animals; Antimanic Agents; Azepines; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; Enzyme Activation; Excitatory Amino Acid Agonists; Gene Products, tat; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; HIV-1; Lithium Chloride; N-Methylaspartate; Neurons; Neurotoxins; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Recombinant Proteins; tat Gene Products, Human Immunodeficiency Virus; Triazoles | 1999 |
Involvement of platelet-activating factor in the modulation of vascular tone in the isolated perfused rabbit kidney.
Topics: Animals; Azepines; Dinoprost; Enzyme Inhibitors; Female; Furans; In Vitro Techniques; Kidney; Lignans; Male; Muscle Tonus; Muscle, Smooth, Vascular; Norepinephrine; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Aggregation Inhibitors; Quinacrine; Rabbits; Renal Circulation; Triazoles; Vasoconstrictor Agents | 1999 |
Role of nitric oxide and platelet-activating factor in cardiac alterations induced by tumor necrosis factor-alpha in the guinea-pig papillary muscle.
Topics: Action Potentials; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Azepines; Cyclooxygenase Inhibitors; Depression, Chemical; Guinea Pigs; Heart; In Vitro Techniques; Indomethacin; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Propranolol; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Human IL-3 stimulates endothelial cell motility and promotes in vivo new vessel formation.
Topics: Animals; Apolipoproteins; Apolipoproteins D; Azepines; Carrier Proteins; Cell Division; Cell Line; Cell Movement; DNA-Binding Proteins; Endothelium, Vascular; Female; Glycoproteins; Humans; Injections, Subcutaneous; Interleukin-3; Macromolecular Substances; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Milk Proteins; Neovascularization, Physiologic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Binding; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Interleukin-3; STAT5 Transcription Factor; Trans-Activators; Triazoles; Tumor Suppressor Proteins | 1999 |
Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis : in vitro and In vivo inhibition by WEB 2086.
Topics: Animals; Arteriosclerosis; Azepines; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Humans; Lipid Peroxidation; Mice; Monocytes; Phospholipid Ethers; Phospholipids; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles | 1999 |
Protection against ventricular fibrillation by the PAF antagonist, BN-50739, involves an ischaemia-selective mechanism.
Topics: Animals; Anti-Arrhythmia Agents; Azepines; Disease Models, Animal; Male; Myocardial Ischemia; Perfusion; Platelet Activating Factor; Protective Agents; Rats; Rats, Wistar; Triazoles; Vasodilation; Ventricular Fibrillation | 1999 |
Effects of PAF on histamine H1 receptor mRNA expression in rat trigeminal ganglia.
Topics: Animals; Azepines; Dactinomycin; Gene Expression Regulation; Kinetics; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Histamine H1; Triazoles; Trigeminal Ganglion | 1999 |
Glomerular effects of cholera toxin in isolated perfused rat kidney: a potential role for platelet activating factor.
Topics: Animals; Azepines; Bucladesine; Cholera Toxin; Glomerular Filtration Rate; In Vitro Techniques; Kidney Glomerulus; Male; Perfusion; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Sodium; Triazoles; Urodynamics | 1999 |
Interleukin-1 beta activates expression of cyclooxygenase-2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: platelet-activating factor as a preferential mediator of cyclooxygenase-2 expression.
Topics: Animals; Azepines; Cyclooxygenase 2; Enzyme Induction; Hippocampus; Interleukin-1; Isoenzymes; Mice; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Recombinant Proteins; Thienopyridines; Triazoles | 1999 |
Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat Kupffer cells.
Topics: Alanine Transaminase; Animals; Azepines; Cell Nucleus; Cells, Cultured; Cytoplasm; DNA-Binding Proteins; Endotoxemia; Gene Expression Regulation, Enzymologic; I-kappa B Proteins; Kupffer Cells; Lipopolysaccharides; Liver; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic; Triazoles | 1999 |
Motility induced by human immunodeficiency virus-1 Tat on Kaposi's sarcoma cells requires platelet-activating factor synthesis.
Topics: Azepines; Cell Movement; Diterpenes; Dose-Response Relationship, Drug; Fibrinolytic Agents; Gene Products, tat; Ginkgolides; HIV-1; Humans; Lactones; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sarcoma, Kaposi; tat Gene Products, Human Immunodeficiency Virus; Triazoles; Tumor Cells, Cultured | 1999 |
Mechanosensitive properties of gastric vagal afferent fibers in the rat.
Topics: Afferent Pathways; Animals; Azepines; Dilatation; Infusions, Intra-Arterial; Male; Mechanoreceptors; Muscle, Smooth; Nerve Fibers; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Stomach; Triazoles; Vagus Nerve | 1999 |
Endotoxaemia in rats: role of NO, PAF and TXA2 in pulmonary neutrophil sequestration and hyperlactataemia.
Topics: Animals; Azepines; Cell Movement; Endotoxemia; Indans; Lactic Acid; Lipopolysaccharides; Lung; Male; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thromboxane A2; Triazoles | 1999 |
Platelet-activating factor and arachidonic acid metabolites mediate tumor necrosis factor and eicosanoid kinetics and cardiopulmonary dysfunction during bacteremic shock.
Topics: Aeromonas hydrophila; Animals; Arachidonic Acid; Azepines; Bridged Bicyclo Compounds, Heterocyclic; Eicosanoids; Female; Gram-Negative Bacterial Infections; Heart Diseases; Hemodynamics; Hypertension, Pulmonary; Lipoxygenase Inhibitors; Masoprocol; Oxazoles; Oxygen; Oxygen Consumption; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Shock, Septic; Swine; Thromboxane A2; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Inhibition of eosinophil activation in bronchoalveolar lavage fluid from atopic asthmatics by Y-24180, an antagonist to platelet-activating factor.
Topics: Adult; Antigens, CD; Asthma; Azepines; Blood Proteins; Bronchi; Bronchoalveolar Lavage Fluid; Eosinophil Granule Proteins; Eosinophils; Female; Fibronectins; Humans; Integrin alpha1; Intercellular Adhesion Molecule-1; Leukocyte Count; Macrophage-1 Antigen; Male; Middle Aged; Platelet Activating Factor; Ribonucleases; Triazoles | 1999 |
Platelet-activating factor induction of secreted phosphatase activity in Trypanosoma cruzi.
Topics: Animals; Azepines; Culture Media, Conditioned; Phosphoprotein Phosphatases; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Triazoles; Trypanosoma cruzi | 1999 |
Platelet-activating factor enhances vascular endothelial growth factor-induced endothelial cell motility and neoangiogenesis in a murine matrigel model.
Topics: Animals; Azepines; Cell Movement; Cells, Cultured; Endothelial Growth Factors; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Lymphokines; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Skin; Triazoles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Helicobacter pylori extracts reduce gastric mucosal blood flow by a nitric oxide-independent but mast cell- and platelet-activating factor receptor-dependent pathway in rats.
Topics: Animals; Azepines; Blood Pressure; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; In Vitro Techniques; Ketotifen; Laser-Doppler Flowmetry; Male; Mast Cells; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Platelet Activating Factor; Rats; Rats, Inbred Lew; Triazoles | 1999 |
Endothelial cells potentiate phagocytic killing by macrophages via platelet-activating factor release.
Topics: Animals; Azepines; Cell Death; Cell Line; Coculture Techniques; Dose-Response Relationship, Drug; Endothelium, Vascular; Macrophages, Peritoneal; Mice; Phagocytes; Phagocytosis; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyridinium Compounds; Triazoles; Tumor Necrosis Factor-alpha | 2000 |
Lipopolysaccharide activates nuclear factor kappaB in rat intestine: role of endogenous platelet-activating factor and tumour necrosis factor.
Topics: Animals; Antibodies, Blocking; Azepines; Cell Nucleus; Electrophoresis; Epithelial Cells; Ileum; Immunohistochemistry; Intestinal Mucosa; Intestines; Lipopolysaccharides; Male; Neutrophils; NF-kappa B; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Triazoles; Tumor Necrosis Factor-alpha | 2000 |
Role of platelet-activating factor in alveolar septal injury associated with experimentally induced pneumonic pasteurellosis in calves.
Topics: Animals; Azepines; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Cattle; Flow Cytometry; Hemoglobins; Intradermal Tests; Leukocyte Count; Lung; Macrophage-1 Antigen; Male; Mannheimia haemolytica; Neutrophils; Pasteurellosis, Pneumonic; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pulmonary Alveoli; Triazoles | 2000 |
Interferon-gamma-induced membrane PAF-receptor expression confers tumor cell susceptibility to NK perforin-dependent lysis.
Topics: Adult; Azepines; Calcium; Cell Membrane; Cytotoxicity, Immunologic; Gene Expression; Humans; Interferon-gamma; Killer Cells, Natural; Membrane Glycoproteins; Neoplasms; Perforin; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pore Forming Cytotoxic Proteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Transfection; Triazoles; Tumor Cells, Cultured | 2000 |
Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin.
Topics: Animals; Azepines; Cadherins; Cytoskeleton; Dextrans; Enzyme Inhibitors; Epithelium; Glucose; Hypotension; Intestinal Mucosa; Intestines; Leukocytosis; Male; Permeability; Phosphorylation; Phosphotyrosine; Platelet Activating Factor; Protein-Tyrosine Kinases; Quinolinium Compounds; Rats; Rats, Sprague-Dawley; Triazoles; Tyrosine; Tyrphostins | 2000 |
The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Azepines; DNA, Complementary; Endotoxemia; Endotoxins; Kupffer Cells; Leukocytes; Lipopolysaccharides; Liver; Macrophages, Peritoneal; Male; Phospholipases A; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Chloride; Tissue Distribution; Triazoles; Up-Regulation | 2000 |
Platelet-activating factor receptors in lamb lungs are downregulated immediately after birth.
Topics: Animals; Animals, Newborn; Azepines; Binding, Competitive; Cell Membrane; DNA, Complementary; Female; Gene Expression Regulation, Developmental; Lung; Molecular Sequence Data; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pregnancy; Pulmonary Circulation; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Nucleic Acid; Sheep; Triazoles; Tritium | 2000 |
Effects of the platelet activating factor antagonists BN 52021 and BN 50730 on antigen-induced bronchial hyperresponsiveness and eosinophil infiltration in lung from sensitized guinea-pigs.
Topics: Acetylcholine; Aerosols; Animals; Azepines; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Diterpenes; Eosinophilia; Ginkgo biloba; Ginkgolides; Guinea Pigs; Lactones; Leukotriene B4; Lung Diseases; Male; Molecular Structure; Ovalbumin; Plants, Medicinal; Platelet Activating Factor; Specific Pathogen-Free Organisms; Thienopyridines; Triazoles | 1993 |
Activation of platelet-activating factor (PAF) receptor stimulates nitric oxide (NO) release via protein kinase C-alpha in HEC-1B human endometrial epithelial cell line.
Topics: Azepines; Calcium; Cell Line; Endometrium; Enzyme Activation; Epithelial Cells; Female; Humans; Indoles; Infertility, Female; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Kinase C-alpha; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles | 2000 |
Reduction of hypoxic-ischemic brain swelling in the neonatal rat with PAF antagonist WEB 2170: lack of long-term protection.
Topics: Animals; Animals, Newborn; Atrophy; Azepines; Brain; Brain Edema; Female; Hypoxia-Ischemia, Brain; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Triazoles; Weight Gain | 2000 |
Y-24180, an antagonist of platelet-activating factor, suppresses interleukin 5 production in cultured murine th(2)cells and human peripheral blood mononuclear cells.
Topics: Animals; Azepines; Cells, Cultured; Gene Expression; Humans; Interleukin-5; Leukocytes, Mononuclear; Mice; Platelet Activating Factor; Platelet Aggregation Inhibitors; Th2 Cells; Triazoles | 2000 |
Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally.
Topics: Animals; Azepines; Cell Adhesion; Indicators and Reagents; Interleukin-1; Intubation, Intratracheal; Leukocyte Count; Lung; Lung Diseases; Male; Neutrophils; Nitroblue Tetrazolium; Permeability; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Time Factors; Triazoles | 2000 |
Platelet activating factor (PAF) antagonists on cytokine induction of iNOS and sPLA2 in immortalized astrocytes (DITNC).
Topics: Animals; Astrocytes; Azepines; Cell Line, Transformed; Cytokines; Diterpenes; Enzyme Induction; Gene Expression Regulation, Enzymologic; Ginkgolides; Group II Phospholipases A2; Interferon-gamma; Interleukin-1; Lactones; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thienopyridines; Triazoles; Tumor Necrosis Factor-alpha | 2000 |
Selective involvement of reactive oxygen intermediates in platelet-activating factor-mediated activation of NF-kappaB.
Topics: Acetylcysteine; Animals; Antioxidants; Azepines; Benzoquinones; Disseminated Intravascular Coagulation; DNA-Binding Proteins; Female; Gene Expression Regulation; Genistein; Hemorrhage; Hydrogen Peroxide; I-kappa B Proteins; Isoflavones; Kidney Medulla; Lactams, Macrocyclic; Lethal Dose 50; Macrophages; Mice; Mice, Inbred C57BL; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Platelet Activating Factor; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pulmonary Edema; Pyrrolidines; Quinones; Reactive Oxygen Species; Rifabutin; Serine Proteinase Inhibitors; Signal Transduction; Specific Pathogen-Free Organisms; Succinic Acid; Thiocarbamates; Tosylphenylalanyl Chloromethyl Ketone; Triazoles; Tumor Necrosis Factor-alpha; Vitamin E | 2000 |
Endothelin-1-induced PMN infiltration and mucosal dysfunction in the rat small intestine.
Topics: Animals; Antibodies, Monoclonal; Azepines; Cell Movement; Endothelin-1; Female; Injections, Intra-Arterial; Intercellular Adhesion Molecule-1; Intestinal Mucosa; Intestine, Small; Luminescent Measurements; Male; Necrosis; Neutrophils; Oxidative Stress; Peroxidase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Triazoles | 2000 |
Synthesis and pharmacological evaluation of novel heterotricyclic acylhydrazone derivatives, designed as PAF antagonists.
Topics: Animals; Azepines; Models, Molecular; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Triazoles | 2000 |
Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Azepines; Calcium; Cytosol; Enzyme Inhibitors; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rabbits; Terpenes; Tosylphenylalanyl Chloromethyl Ketone; Triazoles | 2000 |
PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis.
Topics: Animals; Azepines; Breast Neoplasms; Cell Division; Cell Movement; Female; Humans; Mice; Mice, SCID; Neoplasm Transplantation; Neovascularization, Pathologic; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Tumor Cells, Cultured | 2000 |
Role of NO and PAF in the impairment of skeletal muscle contractility induced by TNF-alpha.
Topics: Animals; Azepines; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Phospholipases A; Platelet Activating Factor; S-Nitroso-N-Acetylpenicillamine; Stereoisomerism; Triazoles; Tumor Necrosis Factor-alpha | 2000 |
PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways.
Topics: Animals; Azepines; Bronchoalveolar Lavage Fluid; Cell Count; Eosinophils; Goblet Cells; Guinea Pigs; Male; Metaplasia; Nicotiana; Peroxidase; Plants, Toxic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Skin; Smoke; Trachea; Triazoles | 2001 |
Tat-induced platelet-activating factor synthesis contributes to the angiogenic effect of HIV-1 Tat.
Topics: Angiogenesis Inducing Agents; Animals; Azepines; Cell Movement; Endothelium, Vascular; Female; Gene Products, tat; HIV-1; Humans; Mice; Mice, Inbred C57BL; Platelet Activating Factor; tat Gene Products, Human Immunodeficiency Virus; Triazoles | 2001 |
The role of platelet-activating factor (PAF) antagonists and nitric oxide in cardiac actions of PAF. Electrophysiological and morphological study.
Topics: 4-Aminopyridine; Action Potentials; Animals; Azepines; Diterpenes; Electrophysiology; Fibrinolytic Agents; Ginkgolides; Glyburide; Guinea Pigs; Heart; In Vitro Techniques; Lactones; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Potassium Channel Blockers; Reperfusion Injury; Triazoles | 2000 |
Preventive effect of platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity.
Topics: Animals; Azepines; Cyclosporine; Dose-Response Relationship, Drug; Endothelin-1; Hemodynamics; Immunosuppressive Agents; Kidney; Male; Platelet Activating Factor; Rats; Rats, Wistar; Thromboxane B2; Triazoles | 2001 |
Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expression.
Topics: Aged; Antibodies; Antioxidants; Azepines; Bacterial Adhesion; Cells, Cultured; Epithelial Cells; Female; Gene Expression; Humans; Hydrochloric Acid; Interleukin-1; Male; Middle Aged; Neutralization Tests; NF-kappa B; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pneumococcal Infections; Pneumonia, Aspiration; Pyrrolidines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Streptococcus pneumoniae; Thiocarbamates; Trachea; Triazoles | 2001 |
[Influences of BN50739 on neutrophil elastase and phospholipase A2 in lung and tracheal mucosa of pigs with acute severe pancreatitis].
Topics: Animals; Azepines; Female; Leukocyte Elastase; Lung; Male; Pancreatitis, Acute Necrotizing; Peroxidase; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Random Allocation; Respiratory Mucosa; Swine; Trachea; Triazoles | 2000 |
Platelet-activating factor (PAF) modulates peritoneal mouse macrophage infection by Leishmania amazonensis.
Topics: Animals; Azepines; Female; Leishmania; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Triazoles | 2001 |
Platelet-activating factor antagonist BN 50730 attenuates hypoxic-ischemic brain injury in neonatal rats.
Topics: Animals; Animals, Newborn; Azepines; Brain Injuries; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Hippocampus; Hypoxia, Brain; Learning; Memory; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Thienopyridines; Triazoles | 2001 |
Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Azepines; Blotting, Northern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Egtazic Acid; Endothelium, Vascular; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; GTP-Binding Proteins; Indoles; Isoquinolines; Lipoproteins, LDL; Pertussis Toxin; Phospholipases A; Platelet Activating Factor; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Signal Transduction; Sulfonamides; Triazoles; Virulence Factors, Bordetella | 2001 |
[The role and significance of PAF in the early pulmonary injury following burns combined with endotoxemia in rats].
Topics: Animals; Azepines; Burns; Endotoxemia; Female; Lung; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Random Allocation; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
The renal effects of Bothrops jararacussu venom and the role of PLA(2) and PAF blockers.
Topics: Animals; Antigens, Human Platelet; Azepines; Biological Transport; Bothrops; Crotalid Venoms; Dexamethasone; Dose-Response Relationship, Drug; Drug Combinations; Female; Glomerular Filtration Rate; In Vitro Techniques; Kidney; Male; Perfusion; Platelet Activating Factor; Platelet Aggregation Inhibitors; Potassium; Pressure; Rats; Rats, Wistar; Renal Circulation; Sodium; Triazoles; Urination; Urodynamics | 2001 |
Effects of platelet activating factor antagonist (BN50739) on gut mucosal injury in acute severe pancreatitis in pigs.
Topics: Acute Disease; Animals; Azepines; Intestinal Mucosa; Pancreatitis; Platelet Activating Factor; Swine; Triazoles | 2000 |
Participation of prostaglandin E2 and platelet-activating factor in thapsigargin-induced production of interleukin-6.
Topics: Acetyltransferases; Acyl-Carrier Protein S-Acetyltransferase; Animals; Azepines; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Furans; Imidazoles; Indomethacin; Interleukin-6; Macrophages, Peritoneal; Male; Organophosphorus Compounds; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Thapsigargin; Triazoles | 2002 |
Anti-CD44 monoclonal antibody (IM7) induces murine systemic shock mediated by platelet activating factor.
Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Antibodies, Monoclonal; Azepines; Capillary Permeability; Cyproheptadine; Diphenhydramine; Erythrocytes; Hyaluronan Receptors; Hypotension; Immunoglobulin Fab Fragments; Immunoglobulin G; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Platelet Activating Factor; Triazoles | 2002 |
In vitro evaluation of the role of platelet-activating factor and interleukin-8 in Mannheimia haemolytica-induced bovine pulmonary endothelial cell injury.
Topics: Animals; Azepines; Cattle; Cattle Diseases; Cell Adhesion; Cell Degranulation; Coculture Techniques; Endothelium, Vascular; Female; Interleukin-8; Macrophages, Alveolar; Mannheimia haemolytica; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Superoxides; Triazoles | 2002 |
Specific PAF antagonist WEB-2086 induces terminal differentiation of murine and human leukemia cells.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Histones; HL-60 Cells; Humans; K562 Cells; Kinetics; Leukemia; Leukemia, Erythroblastic, Acute; Mice; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Triazoles; Tumor Cells, Cultured | 2002 |
PAF antagonist treatment reduces pro-inflammatory cytokine mRNA after spinal cord injury.
Topics: Animals; Azepines; Cytokines; Female; Inflammation Mediators; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Long-Evans; RNA, Messenger; Spinal Cord Injuries; Thoracic Vertebrae; Time Factors; Triazoles | 2002 |
Platelet-activating factor induces cell death in cultured astrocytes and oligodendrocytes: involvement of caspase-3.
Topics: Animals; Animals, Newborn; Antigens, Differentiation; Astrocytes; Azepines; Caspase 3; Caspases; Cell Death; Cells, Cultured; Central Nervous System; Diterpenes; Dose-Response Relationship, Drug; Free Radical Scavengers; Ginkgolides; Glial Fibrillary Acidic Protein; Inflammation; Lactones; Mice; Mice, Inbred CBA; Oligodendroglia; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Spinal Cord Injuries; Triazoles | 2002 |
Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes.
Topics: Animals; Azepines; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; L-Lactate Dehydrogenase; Lung; Male; Phosphatidylcholines; Platelet Activating Factor; Protein Kinase C; Rats; Rats, Wistar; Stimulation, Chemical; Time Factors; Triazoles | 2002 |
Evaluation of lipopolysaccharide-induced activation of equine neutrophils.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Azepines; CD11 Antigens; CD18 Antigens; Cell Degranulation; Complement System Proteins; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Flow Cytometry; Horses; Interleukin-8; Lipopolysaccharides; Neutrophil Activation; Neutrophils; Pentoxifylline; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles; Tumor Necrosis Factor-alpha | 2002 |
Possible participation of intracellular platelet-activating factor in NF-kappaB activation in rat peritoneal macrophages.
Topics: Animals; Azepines; Base Sequence; Cells, Cultured; DNA Primers; Hydrolysis; Imidazoles; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Organophosphorus Compounds; Phosphorylation; Piperidines; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Thapsigargin; Triazoles | 2002 |
Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation.
Topics: Azepines; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Fatty Acids, Omega-3; Humans; Intercellular Adhesion Molecule-1; Monocytes; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2002 |
Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice.
Topics: Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Azepines; Bile Ducts; Caco-2 Cells; Carbon Radioisotopes; Humans; Intestinal Mucosa; Male; Mice; Mice, Knockout; Platelet Activating Factor; Tissue Distribution; Triazoles | 2002 |
Platelet-activating factor does not mediate circulatory failure induced by 35-GHz microwave heating.
Topics: Animals; Azepines; Fever; Hemodynamics; Hypotension; Male; Microwaves; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles | 2002 |
Molecular mechanisms for lipopolysaccharide-induced biphasic activation of nuclear factor-kappa B (NF-kappa B).
Topics: Animals; Azepines; Cell Line; Female; Interleukin-1; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Platelet Activating Factor; Pyridinium Compounds; Receptors, Interleukin-1; Signal Transduction; Time Factors; Triazoles; Tumor Necrosis Factor-alpha | 2002 |
Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats.
Topics: Animals; Azepines; Diterpenes; Dose-Response Relationship, Drug; Formaldehyde; Ginkgolides; Inflammation; Lactones; Male; Pain; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thienopyridines; Time Factors; Triazoles | 2002 |
Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10.
Topics: Arachidonic Acid; Autocrine Communication; Azepines; Escherichia coli; Humans; In Vitro Techniques; Indoles; Interleukin-10; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Lipopolysaccharide Receptors; Lipopolysaccharides; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Prospective Studies; Respiratory Burst; Superoxides; Triazoles | 2002 |
In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock.
Topics: Animals; Azepines; Cell Adhesion; Endothelium, Vascular; Fluorescent Dyes; Leukocytes; Lymphocyte Function-Associated Antigen-1; Male; Microcirculation; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Resuscitation; Rhodamines; Shock, Hemorrhagic; Triazoles | 2002 |
Platelet-activating factor induces lung inflammation and leak in rats: hydrogen peroxide production along neutrophil-lung endothelial cell interfaces.
Topics: Animals; Azepines; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cell Count; Endothelium, Vascular; Hydrogen Peroxide; Intercellular Junctions; Intubation, Intratracheal; Lung; Male; Neutrophils; NF-kappa B; Peroxidase; Platelet Activating Factor; Pneumonia; Rats; Rats, Sprague-Dawley; Triazoles | 2002 |
Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Azepines; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Drug Synergism; Epinephrine; Flurbiprofen; Humans; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Signal Transduction; Triazoles; Verapamil; Yohimbine | 2003 |
A new method to evaluate spontaneous platelet aggregation in type 2 diabetes by Cellfacts.
Topics: Adenosine Diphosphate; Antioxidants; Azepines; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; In Vitro Techniques; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Triazoles; Vitamin E | 2003 |
Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C.
Topics: Adolescent; Adult; Aged; Apoptosis; Azepines; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Injury Severity Score; Maleimides; Middle Aged; Neutrophils; Phospholipids; Plasma; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Kinase C; Signal Transduction; Time Factors; Triazoles; Wounds and Injuries | 2001 |
Mesenteric microvascular inflammatory responses to systemic hypoxia are mediated by PAF and LTB4.
Topics: Animals; Azepines; Capillary Permeability; Cell Adhesion; Fluorescence; Hypoxia; Leukocytes; Leukotriene B4; Male; Microcirculation; Oxidants; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Leukotriene B4; Rhodamines; Splanchnic Circulation; Triazoles; Vasculitis | 2003 |
The role of platelet activating factor and the efficacy of apafant ophthalmic solution in experimental allergic conjunctivitis.
Topics: Animals; Antigens; Azepines; Capillary Permeability; Conjunctivitis, Allergic; Disease Models, Animal; Dose-Response Relationship, Drug; Dye Dilution Technique; Guinea Pigs; Humans; Immunization, Passive; Ketotifen; Male; Ophthalmic Solutions; Platelet Activating Factor; Pruritus; Time Factors; Triazoles | 2003 |
Platelet-activating factor mediates CD40-dependent angiogenesis and endothelial-smooth muscle cell interaction.
Topics: Animals; Antibodies, Monoclonal; Azepines; CD40 Antigens; CD40 Ligand; Cell Communication; Cell Movement; Cells, Cultured; Collagen; Drug Combinations; Endothelium, Vascular; Female; Humans; Injections, Subcutaneous; Intracellular Fluid; Laminin; Mice; Mice, Inbred C57BL; Models, Immunological; Muscle, Smooth, Vascular; Neovascularization, Physiologic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteoglycans; Receptors, G-Protein-Coupled; Triazoles | 2003 |
Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility.
Topics: Animals; Azepines; Class Ib Phosphatidylinositol 3-Kinase; Female; In Vitro Techniques; Isoenzymes; Mice; Mice, Knockout; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Perfusion; Phosphatidylinositol 3-Kinases; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles | 2003 |
Candidate's thesis: Platelet-activating factor-induced hearing loss: mediated by nitric oxide?
Topics: Animals; Azepines; Cochlea; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Hair Cells, Auditory; Hearing Loss; Immunohistochemistry; Longitudinal Studies; Microscopy, Electron, Scanning; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Activating Factor; Random Allocation; Round Window, Ear; Triazoles | 2003 |
Effect of inhibitors of leukotriene and/or platelet activating factor on killed H. influenzae induced experimental otitis media with effusion.
Topics: Animals; Arachidonic Acid; Azepines; Case-Control Studies; Chinchilla; Chromatography, High Pressure Liquid; Haemophilus influenzae; Injections, Intraperitoneal; Leukotriene Antagonists; Leukotrienes; Naphthyridines; Otitis Media with Effusion; Platelet Activating Factor; Platelet Aggregation Inhibitors; Random Allocation; Temporal Bone; Triazoles | 2004 |
The role of platelet activating factor in a neonatal piglet model of necrotising enterocolitis.
Topics: Animals; Animals, Newborn; Azepines; Blood Gas Analysis; Blood Pressure; Enterocolitis, Necrotizing; Hypoxia; Intestinal Mucosa; Lipopolysaccharides; Mesenteric Arteries; Models, Animal; Platelet Activating Factor; Regional Blood Flow; Swine; Triazoles; Vascular Resistance | 2004 |
Effect of platelet activating factor with and without receptor antagonist (WEB2170) on morphology of isolated cochlear outer hair cells.
Topics: Albumins; Animals; Azepines; Chinchilla; Hair Cells, Auditory, Outer; Platelet Activating Factor; Sodium Chloride; Triazoles | 2004 |
Left regional cardiac perfusion in vitro with platelet-activating factor, norepinephrine and K+ reveals that ischaemic arrhythmias are caused by independent effects of endogenous "mediators" facilitated by interactions, and moderated by paradoxical antago
Topics: Animals; Azepines; Coronary Vessels; Heart Ventricles; In Vitro Techniques; Male; Myocardial Ischemia; Norepinephrine; Perfusion; Platelet Activating Factor; Potassium; Rats; Rats, Wistar; Triazoles; Ventricular Fibrillation; Ventricular Function | 2004 |
Determination of specific receptor sites for platelet activating factor in bovine neutrophils.
Topics: Animals; Azepines; Base Sequence; Blotting, Western; Cattle; Cyclooctanes; Diterpenes; DNA Primers; DNA, Complementary; Enzyme-Linked Immunosorbent Assay; Ginkgolides; HL-60 Cells; Humans; Kinetics; Lactones; Lignans; Molecular Sequence Data; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polycyclic Compounds; Radioligand Assay; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Triazoles; Tritium | 2004 |
Involvement of platelet activating factor in immediate heart response to lipopolysaccharide.
Topics: Animals; Azepines; Cell Line; Dose-Response Relationship, Drug; Enzyme Induction; Escherichia coli; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Myocardial Contraction; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phospholipid Ethers; Platelet Activating Factor; Rats; Receptors, Leukotriene; Receptors, Thromboxane A2, Prostaglandin H2; Triazoles | 2004 |
Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs.
Topics: Administration, Topical; Animals; Azepines; Chronic Disease; Conjunctiva; Conjunctivitis, Allergic; Dose-Response Relationship, Drug; Eosinophil Peroxidase; Eosinophils; Guinea Pigs; Male; Ophthalmic Solutions; Ovalbumin; Platelet Activating Factor; Tears; Triazoles | 2004 |
Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells.
Topics: Animals; Antibodies; Azepines; Cattle; Cell Division; Cell Movement; Cells, Cultured; Corneal Neovascularization; Dose-Response Relationship, Drug; Endothelial Cells; Fibroblast Growth Factor 2; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; RNA, Messenger; Skin; Thienopyridines; Triazoles; Umbilical Veins; Up-Regulation; Vascular Endothelial Growth Factor A | 2004 |
Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation.
Topics: Alkaloids; Animals; Azepines; Benzophenanthridines; Cardiotonic Agents; Chromones; Coronary Circulation; Enzyme Inhibitors; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Morpholines; Myocardial Reperfusion Injury; Myocardium; Necrosis; Perfusion; Phenanthridines; Phosphatidylinositol 3-Kinases; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Kinase C; Rats; Rats, Wistar; Triazoles; Ventricular Function, Left | 2005 |
Eosinophil trans-basement membrane migration induced by interleukin-8 and neutrophils.
Topics: Adult; Antibodies, Monoclonal; Asthma; Azepines; Basement Membrane; Chemotaxis, Leukocyte; Coculture Techniques; Collagen; Culture Media, Conditioned; Drug Combinations; Eosinophils; Humans; Interleukin-8; Laminin; Leukotriene B4; Matrix Metalloproteinase 9; Neutrophil Activation; Neutrophils; Paracrine Communication; Platelet Activating Factor; Protease Inhibitors; Proteoglycans; Pulmonary Eosinophilia; Triazoles; Tumor Necrosis Factor-alpha | 2006 |
Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086.
Topics: Azepines; Breast Neoplasms; Cathepsin D; Cell Cycle; Cell Differentiation; Cell Division; Cell Line, Tumor; Cell Movement; Humans; Platelet Activating Factor; Triazoles | 2006 |
Lipopolysaccharide induces CXCL2/macrophage inflammatory protein-2 gene expression in enterocytes via NF-kappaB activation: independence from endogenous TNF-alpha and platelet-activating factor.
Topics: Animals; Azepines; Cell Line; Chemokine CXCL2; Chemokines, CXC; Dose-Response Relationship, Immunologic; Electrophoretic Mobility Shift Assay; Enterocytes; Gene Expression Regulation; I-kappa B Proteins; Lipopolysaccharides; NF-kappa B; NF-KappaB Inhibitor alpha; Platelet Activating Factor; Pyrrolidines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Triazoles; Tumor Necrosis Factor-alpha | 2006 |
WEB 2086, a platelet-activating factor antagonist, inhibits prophenoloxidase-activating system and hemocyte microaggregation reactions induced by Trypanosoma rangeli infection in Rhodnius prolixus hemolymph.
Topics: Animals; Azepines; Catechol Oxidase; Enzyme Precursors; Hemocytes; Hemolymph; Larva; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rhodnius; Triazoles; Trypanosoma | 2006 |
Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus. Evidence for interaction with platelet activating factor receptor.
Topics: Analgesics; Animals; Anisoles; Anti-Inflammatory Agents; Azepines; Binding, Competitive; Carrageenan; Cerebral Cortex; Dioxoles; Inflammation; Lignans; Male; Mice; Pain Measurement; Pain Threshold; Peroxidase; Phyllanthus; Plant Extracts; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pleurisy; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Tetrahydronaphthalenes; Time Factors; Triazoles | 2006 |
Platelet-activating factor (PAF) is the effector of IFN gamma-stimulated invasiveness and motility in a B16 melanoma line.
Topics: Animals; Azepines; Cell Movement; Collagen; Culture Media, Conditioned; Drug Combinations; Interferon-gamma; Laminin; Melanoma; Mice; Neoplasm Invasiveness; Phenotype; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Proteoglycans; Receptors, G-Protein-Coupled; Stress Fibers; Time Factors; Triazoles; Tumor Cells, Cultured | 2006 |
Acute pancreatitis affects non-parenchymal liver cells by a mechanism dependent on platelet-activating factor.
Topics: Acute Disease; Animals; Azepines; Candida albicans; Kupffer Cells; Lipopolysaccharides; Liver; Male; Nitric Oxide; Pancreatitis; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Taurocholic Acid; Triazoles; Tumor Necrosis Factors | 2007 |
Opposite effects of WEB2086 on angiogenesis in atheromas and ischemic hindlimb of apoE gene deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Azepines; Capillaries; Cholesterol; Hindlimb; Ischemia; Lipoproteins, LDL; Male; Mice; Neovascularization, Physiologic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Triazoles | 2007 |
Inverse agonist-induced signaling and down-regulation of the platelet-activating factor receptor.
Topics: Animals; Azepines; Chlorocebus aethiops; COS Cells; Down-Regulation; Lysosomes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteasome Inhibitors; Protein Kinase C; Protein Transport; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles | 2007 |
The effects of platelet-activating factor on the secretion of interleukin-8 and growth-regulated oncogene alpha in human immortalized granulosa cell line (GC1a).
Topics: Azepines; Cell Line; Chemokine CXCL1; Enzyme-Linked Immunosorbent Assay; Female; Granulosa Cells; Humans; Interleukin-8; Ovulation; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Triazoles | 2007 |
Blockades of phospholipase A(2) and platelet-activating factor receptors reduce the hemocyte phagocytosis in Rhodnius prolixus: in vitro experiments.
Topics: Animals; Azepines; Eicosanoids; Hemocytes; Heteroptera; Larva; Phagocytosis; Phospholipase A2 Inhibitors; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Triazoles | 2008 |
Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses.
Topics: Animals; Aspirin; Azepines; Benzamides; Blood Platelets; Calcimycin; Female; Horses; Leukocytes; Lipopolysaccharides; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, G-Protein-Coupled; Serotonin; Thromboxane A2; Time Factors; Triazoles; Tryptamines; Vasoconstriction | 2008 |
Platelet-activating factor stimulates ovine foetal pulmonary vascular smooth muscle cell proliferation: role of nuclear factor-kappa B and cyclin-dependent kinases.
Topics: Animals; Azepines; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Female; Flavonoids; Hypoxia; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; NF-kappa B; Oxygen; Platelet Activating Factor; Pulmonary Artery; Pulmonary Veins; Sheep; Structure-Activity Relationship; Triazoles | 2008 |
Effect of platelet-activating factor antagonist WEB 2086 on microcirculatory disorders in acute experimental pancreatitis of graded severity.
Topics: Amylases; Animals; Azepines; Capillaries; Cell Adhesion; Ceruletide; Disease Models, Animal; Edema; Female; Glycodeoxycholic Acid; Leukocytes; Microcirculation; Oligopeptides; Pancreas; Pancreatitis; Pancreatitis, Acute Necrotizing; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Regional Blood Flow; Severity of Illness Index; Taurocholic Acid; Time Factors; Triazoles | 2009 |
Comparison of the anti-inflammatory activities of imidazole antimycotics in relation to molecular structure.
Topics: Anti-Inflammatory Agents; Antifungal Agents; Cells, Cultured; Fluconazole; Humans; Imidazoles; Itraconazole; Ketoconazole; Leukotriene B4; Molecular Structure; Neutrophils; Platelet Activating Factor; Pyrimidines; Triazoles; Voriconazole | 2008 |
Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw.
Topics: Animals; Azepines; Forelimb; Male; Pain; Pain Measurement; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Triazoles | 2009 |
Posaconazole attenuates leukotriene B4 release and uptake of calcium by chemoattractant-activated human neutrophils: a potential strategy to control neutrophil-mediated inflammation.
Topics: Adult; Anti-Inflammatory Agents; Calcium; Humans; Immunoassay; Immunologic Factors; Leukotriene B4; Neutrophils; Platelet Activating Factor; Spectrometry, Fluorescence; Triazoles; Young Adult | 2009 |
Toll-like receptor ligands induce polymorphonuclear leukocyte migration: key roles for leukotriene B4 and platelet-activating factor.
Topics: Animals; Azepines; Cell Movement; Dihydropyridines; Female; Flagellin; Humans; Imidazoles; Leukotriene B4; Ligands; Mice; Mice, Inbred C57BL; Neutrophils; Platelet Activating Factor; Poly I-C; Propionates; Quinolines; Thienopyridines; Toll-Like Receptors; Triazoles | 2010 |
Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor.
Topics: Animals; Azepines; Cell Degranulation; Eosinophils; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Triazoles | 2010 |
Neutrophils reduce the parasite burden in Leishmania (Leishmania) amazonensis-infected macrophages.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antibodies; Azepines; Cell Communication; Cells, Cultured; Coculture Techniques; Cytokines; Female; Host-Parasite Interactions; Leishmania; Leukocyte Elastase; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Microscopy, Fluorescence; Neutrophils; Nitric Oxide; Platelet Activating Factor; Reactive Oxygen Species; Triazoles; Tumor Necrosis Factor-alpha | 2010 |
Effects of the new benzimidazole derivative TAS-203, an orally active phosphodiesterase 4 inhibitor, on airway inflammation in rats and emetic responses in ferrets.
Topics: Animals; Anti-Inflammatory Agents; Benzimidazoles; Chemotaxis, Leukocyte; Cloning, Molecular; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Ferrets; Guinea Pigs; Humans; Inflammation; Lipopolysaccharides; Male; Nitriles; Phosphodiesterase 4 Inhibitors; Platelet Activating Factor; Rats; Rats, Inbred BN; Rats, Inbred Lew; Respiratory Tract Diseases; Tissue Distribution; Triazoles; Tumor Necrosis Factor-alpha; Vomiting | 2010 |
Effects of platelet-activating factor on the interaction of Trypanosoma cruzi with Rhodnius prolixus.
Topics: Animals; Azepines; Chagas Disease; Host-Parasite Interactions; N-Acetylneuraminic Acid; Neuraminidase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rhodnius; Triazoles; Trypanosoma cruzi | 2011 |
Noninvasive molecular imaging reveals role of PAF in leukocyte-endothelial interaction in LPS-induced ocular vascular injury.
Topics: Animals; Azepines; Ginkgolides; Lactones; Leukocyte Rolling; Lipopolysaccharides; Male; Membrane Glycoproteins; Molecular Imaging; Platelet Activating Factor; Rats; Rats, Inbred Lew; Triazoles; Uveitis | 2011 |
Lipopolysaccharide and platelet-activating factor stimulate expression of platelet-activating factor acetylhydrolase via distinct signaling pathways.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Azepines; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Imidazoles; Lipopolysaccharides; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, G-Protein-Coupled; RNA, Messenger; Triazoles | 2011 |
Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.
Topics: Acidosis; Alkalosis; Animals; Azepines; Benzophenanthridines; Dose-Response Relationship, Drug; Flavonoids; Guanidines; Guinea Pigs; Heart Ventricles; Hydrogen-Ion Concentration; Indoles; Ion Transport; Maleimides; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Kinase Inhibitors; Receptors, G-Protein-Coupled; Signal Transduction; Sodium; Sodium-Hydrogen Exchangers; Spectrometry, Fluorescence; Sulfones; Time Factors; Triazoles | 2011 |
Albuterol isomers modulate platelet-activating factor synthesis and receptor signaling in human bronchial smooth muscle cells.
Topics: Albuterol; Azepines; Bronchi; Bronchodilator Agents; Cell Line; Cell Proliferation; Humans; Inositol 1,4,5-Trisphosphate; Myocytes, Smooth Muscle; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles | 2012 |
Synthesis, biochemical evaluation and molecular modeling studies of novel rhodium complexes with nanomolar activity against Platelet Activating Factor.
Topics: Animals; Azepines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Dynamics Simulation; Organometallic Compounds; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Rhodium; Structure-Activity Relationship; Thrombin; Triazoles | 2013 |
Reactivation of desensitized formyl peptide receptors by platelet activating factor: a novel receptor cross talk mechanism regulating neutrophil superoxide anion production.
Topics: Actins; Azepines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Cyclosporine; Cytochalasin B; Cytoskeleton; Gelsolin; Humans; Marine Toxins; NADPH Oxidases; Neutrophils; Oligopeptides; Oxazoles; Peptide Fragments; Platelet Activating Factor; Receptors, Formyl Peptide; Superoxides; Thiazolidines; Triazoles | 2013 |
Cooperative role of endogenous leucotrienes and platelet-activating factor in ischaemia-reperfusion-mediated tissue injury.
Topics: Amidines; Animals; Azepines; Biological Assay; Carbamates; Dermis; Disease Models, Animal; Extravasation of Diagnostic and Therapeutic Materials; Extremities; Inflammation; Leukotriene B4; Leukotrienes; Male; Mice; Mice, Inbred C57BL; Myocardial Ischemia; Neutrophil Infiltration; Platelet Activating Factor; Platelet Membrane Glycoproteins; Propionates; Quinolines; Rabbits; Receptors, G-Protein-Coupled; Receptors, Leukotriene; Reperfusion Injury; Triazoles | 2013 |
Central role of PAFR signalling in ExoU-induced NF-κB activation.
Topics: Animals; Azepines; Bacterial Proteins; Bacterial Toxins; Cell Line; Enzyme Activation; Female; Gene Expression Regulation; Humans; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Promoter Regions, Genetic; Protein Binding; Pseudomonas aeruginosa; Pseudomonas Infections; Receptors, G-Protein-Coupled; Signal Transduction; Transcription Factor RelA; Triazoles | 2014 |
Structural and functional analysis of a platelet-activating lysophosphatidylcholine of Trypanosoma cruzi.
Topics: Animals; Azepines; Lysophosphatidylcholines; Models, Molecular; Molecular Docking Simulation; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Receptors, G-Protein-Coupled; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Triazoles; Trypanosoma cruzi | 2014 |
Expression of the platelet-activating factor receptor enhances benzyl isothiocyanate-induced apoptosis in murine and human melanoma cells.
Topics: Animals; Apoptosis; Azepines; Cell Line; Cell Proliferation; Gene Expression Regulation; Humans; Isothiocyanates; Melanoma; Mice; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Reactive Oxygen Species; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles | 2015 |
Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs.
Topics: Animals; Azepines; Dogs; Edema; Erythema; Histamine; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prednisolone; Receptors, G-Protein-Coupled; Skin; Skin Diseases; Triazoles | 2016 |
Modulation of inflammatory platelet-activating factor (PAF) receptor by the acyl analogue of PAF.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Azepines; Chromatography, Liquid; Female; Healthy Volunteers; Lysophosphatidylcholines; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Knockout; Phospholipids; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Triazoles | 2018 |
Human mesenchymal stem cells in the tumour microenvironment promote ovarian cancer progression: the role of platelet-activating factor.
Topics: Animals; Azepines; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Disease Progression; Female; Humans; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Triazoles; Tumor Microenvironment | 2018 |
Effect of Platelet-Activating Factor on Barrier Function of ARPE-19 Cells.
Topics: Azepines; Cadherins; Cell Line; Cell Membrane Permeability; Electric Impedance; Humans; Neovascularization, Physiologic; Platelet Activating Factor; Platelet Aggregation Inhibitors; Retinal Pigment Epithelium; Tight Junctions; Triazoles; Vascular Endothelial Growth Factor A; Zonula Occludens-1 Protein | 2020 |