Page last updated: 2024-09-02

1-hexadecyl-2-acetyl-glycero-3-phosphocholine and ticlopidine

1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with ticlopidine in 13 studies

Compound Research Comparison

Studies
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Trials
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Recent Studies (post-2010)
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Studies
(ticlopidine)
Trials
(ticlopidine)
Recent Studies (post-2010) (ticlopidine)
9,15618755210,2891,8934,671

Protein Interaction Comparison

ProteinTaxonomy1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50)ticlopidine (IC50)
Alpha-2A adrenergic receptorHomo sapiens (human)0.382
Cytochrome P450 2D6Homo sapiens (human)6.2928
Alpha-2B adrenergic receptorHomo sapiens (human)0.304
Alpha-2C adrenergic receptorHomo sapiens (human)1.175
Cytochrome P450 2B6Homo sapiens (human)0.405
Cytochrome P450 2C19Homo sapiens (human)0.6678
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.426

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19903 (23.08)18.7374
1990's6 (46.15)18.2507
2000's2 (15.38)29.6817
2010's2 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kinjoh, K; Kosugi, T; Nakamura, M; Saitoh, S1
Grunfeld, S; Han, E; Joseph, R; Robertson, W1
Horie, M; Mase, T; Nagaoka, H; Sakurai, Y; Tomioka, K; Yamada, T1
Benveniste, J; Bouloux, C; Chignard, M; Delautier, D; Lalau Keraly, C; Motte, G; Sebag, C1
Benveniste, J; Chignard, M; Delabassee, D; Delautier, D; Lalau Keraly, C1
Conard, J; Horellou, MH; Lecrubier, C; Samama, M1
Bernat, A; Herbert, JM1
Hirata, Y; Matsuno, H; Nakashima, M; Takiguchi, Y; Uematsu, T; Umemura, K; Wada, K1
Obata, Y; Oda, M; Yamamoto, N; Yokota, K1
Budaj, A; Copland, I; Eikelboom, JW; Johnston, M; Maciejewski, P; Weitz, JI; Yusuf, S; Zhao, F1
Farhan, S; Glogar, D; Gyöngyösi, M; Hemetsberger, H; Hemetsberger, R; Huber, K; Pavo, I; Petrasi, Z; Posa, A; Sperker, W; Strehblow, C1
Antman, EM; Braunwald, E; Costigan, TM; Frelinger, AL; Jakubowski, JA; McCabe, CH; Michelson, AD; Miller, DL; Neumann, FJ; Trenk, D; Wiviott, SD1
Dong, CM; Jia, XQ; Qin, J; Zhang, L1

Trials

4 trial(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and ticlopidine

ArticleYear
Effect of ticlopidine and aspirin on platelet ionized calcium in ischemic stroke.
    Stroke, 1991, Volume: 22, Issue:4

    Topics: Aspirin; Blood Platelets; Brain Ischemia; Calcium; Collagen; Humans; In Vitro Techniques; Platelet Activating Factor; Thrombin; Ticlopidine

1991
Clopidogrel does not suppress blood markers of coagulation activation in aspirin-treated patients with non-ST-elevation acute coronary syndromes.
    European heart journal, 2002, Volume: 23, Issue:22

    Topics: Antigens; Aspirin; Biomarkers; Blood Coagulation; Blood Coagulation Factors; Clopidogrel; Cohort Studies; Coronary Disease; Drug Therapy, Combination; Female; Fibrin Fibrinogen Degradation Products; Humans; Male; Middle Aged; P-Selectin; Platelet Activating Factor; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome; von Willebrand Factor

2002
Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel. Results from PRINCIPLE-TIMI 44.
    Thrombosis and haemostasis, 2011, Volume: 106, Issue:2

    Topics: Adenosine Diphosphate; Aged; Clopidogrel; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperazines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine

2011
[Changes in coagulation and fibrinolysis in the patients with coronary heart disease in acute period and effect of drug intervention].
    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2012, Volume: 24, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Blood Coagulation; Case-Control Studies; Clopidogrel; Coronary Disease; Double-Blind Method; Female; Fibrin Fibrinogen Degradation Products; Fibrinolysis; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activating Factor; Prospective Studies; Ticlopidine; Tissue Plasminogen Activator; von Willebrand Factor

2012

Other Studies

9 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and ticlopidine

ArticleYear
Changes of rabbit platelet function on simultaneous administration of ticlopidine hydrochloride and OKY-046.
    International journal of tissue reactions, 1991, Volume: 13, Issue:3

    Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arachidonic Acid; Collagen; Drug Interactions; Drug Synergism; Methacrylates; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Statistics as Topic; Ticlopidine

1991
Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat.
    Biochemical and biophysical research communications, 1991, Apr-30, Volume: 176, Issue:2

    Topics: Animals; Azepines; Disease Models, Animal; Glomerulonephritis, Membranous; Hypercholesterolemia; Male; Metabolic Clearance Rate; Methylprednisolone; Piperazines; Platelet Activating Factor; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Ticlopidine; Triazoles

1991
Reduced sensitivity of human platelets to PAF-acether following ticlopidine intake.
    Haemostasis, 1989, Volume: 19, Issue:4

    Topics: Adenosine Diphosphate; Administration, Oral; Arachidonic Acid; Arachidonic Acids; Humans; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine

1989
Inhibition by ticlopidine of Paf-acether-induced in vitro aggregation of rabbit and human platelets.
    Thrombosis research, 1984, Jun-15, Volume: 34, Issue:6

    Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Humans; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thiophenes; Ticlopidine

1984
Study of platelet aggregation induced by platelet activating factor (PAF) after administration of ticlopidine or aspirin.
    Agents and actions, 1983, Volume: 13, Issue:1

    Topics: Adult; Aged; Anticoagulants; Aspirin; Epinephrine; Humans; In Vitro Techniques; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Thiophenes; Ticlopidine

1983
Effect of various drugs on adriamycin-enhanced venous thrombosis in the rat: importance of PAF.
    Thrombosis research, 1994, Jul-01, Volume: 75, Issue:1

    Topics: Animals; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Doxorubicin; Leukocyte Count; Male; Platelet Activating Factor; Platelet Count; Rats; Rats, Sprague-Dawley; Thiazoles; Thrombophlebitis; Ticlopidine

1994
Roles of platelet-activating factor, thromboxane A2, ADP and thrombin in thrombogenesis in the guinea pig.
    European journal of pharmacology, 1993, Feb-16, Volume: 231, Issue:3

    Topics: Adenosine Diphosphate; Animals; Azepines; Biphenyl Compounds; Guinea Pigs; Heptanoic Acids; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2; Ticlopidine; Triazoles

1993
Inhibitory effects of the new anti-platelet agent KBT-3022 and its metabolite on rabbit neutrophil function in vitro.
    Japanese journal of pharmacology, 1996, Volume: 70, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Calcium; Cell Adhesion; Cilostazol; Complement C3-C5 Convertases; Complement C5a; Cyclooxygenase Inhibitors; Indomethacin; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Structure-Activity Relationship; Superoxides; Tetradecanoylphorbol Acetate; Tetrazoles; Thiazoles; Ticlopidine

1996
Association between the efficacy of dual antiplatelet therapy and the development of in-stent neointimal hyperplasia in porcine coronary arteries.
    Coronary artery disease, 2008, Volume: 19, Issue:8

    Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Animals; Aspirin; Cell Proliferation; Clopidogrel; Collagen; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Fibrin; Hyperplasia; Inflammation Mediators; Metals; P-Selectin; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prosthesis Design; Stents; Swine; Ticlopidine; Time Factors; Tunica Intima

2008