1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with thiazoles in 220 studies
| Studies (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Trials (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Recent Studies (post-2010) (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Studies (thiazoles) | Trials (thiazoles) | Recent Studies (post-2010) (thiazoles) |
|---|---|---|---|---|---|
| 9,156 | 187 | 552 | 33,179 | 2,100 | 12,330 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 82 (37.27) | 18.7374 |
| 1990's | 129 (58.64) | 18.2507 |
| 2000's | 8 (3.64) | 29.6817 |
| 2010's | 1 (0.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adler, KB; Akley, NJ; Glasgow, WC | 1 |
| Herbert, JM | 1 |
| Turner, NC; Wood, LJ | 1 |
| Herbert, JM; Laplace, MC; Maffrand, JP | 2 |
| Eliakim, R; Karmeli, F; Ligumsky, M; Rachmilewitz, D; Simon, P | 1 |
| Asano, M; Hamada, K; Inamura, N; Isono, T; Kohsaka, M; Nagayoshi, A; Nakahara, K; Notsu, Y; Oku, T; Ono, T | 1 |
| Bernat, A; Herbert, JM; Lespy, L; Maffrand, JP; Salel, V | 1 |
| Bernat, A; Herbert, JM; Laplace, MC; Maffrand, JP; Salel, V | 1 |
| Carroll, ML; DeJoy, SQ; Kerwar, SS; Kohler, CA; Oronsky, AL; Pickett, WC; Schaub, RE; Torley, LW; Wissner, A | 1 |
| Binnaka, T; Fujimura, K; Inoue, K; Kitagawa, S; Kubota, Y; Mizuno, T; Tani, K; Yamaguchi, T | 1 |
| Adams, MB; Komorowski, R; McManus, RP; Moore, G; O'Hair, DP; Pieper, GM; Roza, AM | 1 |
| Lewis, SA; Raeburn, D; Underwood, SL | 1 |
| Imanishi, N; Morooka, S; Uchida, M | 1 |
| Bin, Z; Kun, L | 1 |
| Cavero, I; Floch, A; Sedivy, P; Tahraoui, L | 1 |
| Bernat, A; Gigo, V; Herbert, JM; Lale, A; LaPlace, MC; Le Fur, G; Lespy, L; Maffrand, JP; Savi, P; Valette, G | 1 |
| Hara, H; Mase, T; Murase, K; Nagaoka, H; Saito, M; Tomioka, K; Yamada, T | 1 |
| Claude, JR; Martin, C; Massicot, F; Pham Huy, C; Thevenin, M; Warnet, JM | 1 |
| Gilfillan, AM; Hope, WC; Patel, BJ; Welton, AF; Wiggan, GA | 1 |
| Foreman, JC; Hayes, NA; McLeod, J | 1 |
| Bompart, F; Bruno, R; Clucas, A; Gaillot, J; Gregoire, J; Pinquier, JL; Sedivy, P; Strauch, G | 1 |
| Herbert, JM; Lespy, L; Maffrand, JP | 1 |
| Imanishi, N; Morooka, S; Sugasawa, T; Uchida, M | 1 |
| Imanishi, N; Morooka, S; Sugasawa, T | 1 |
| Fukushige, J; Ijima, Y; Koike, H; Miyamoto, M; Nakamura, N; Sada, T | 1 |
| Braquet, P; Ferreira, MG; Fonteles, MC | 1 |
| Imanishi, N; Komuro, Y; Morooka, S | 1 |
| Fukushi, K; Ishitani, K; Ishitani, M; Mikami, T; Suzuki, M; Suzuki, S | 1 |
| Boarder, MR; Jones, JA; Owen, PJ | 1 |
| de Nucci, G; Mitchell, JA; Vane, JR; Warner, TD | 1 |
| Hirafuji, M; Shinoda, H | 1 |
| Bonne, C; Meynier, F; Muller, A | 1 |
| Horie, M; Mase, T; Nagaoka, H; Sakurai, Y; Tomioka, K; Yamada, T | 1 |
| Burrell, R; Keller, GE; Lantz, RC | 1 |
| Bertrand, C; Landry, Y; Tschirhart, E | 1 |
| Kaliner, M; Logun, C; Lundgren, JD; Shelhamer, JH | 1 |
| Mong, S; Votta, B | 1 |
| Hirst, JJ; Jenkin, G; Rice, GE; Thorburn, GD | 1 |
| Hiura, M; Ishibashi, S; Ohtsuka, T; Okamura, N; Ozawa, M | 1 |
| Dickinson, KE; Hirschowitz, BI; Hokin, LE; Pruitt, RE; Sekar, MC | 1 |
| Bloom, JW; Gomez, J; Halonen, M; Yamamura, HI | 1 |
| Bazill, GW; Dexter, TM | 1 |
| Abe, S; Katayama, K; Katayama, S; Sakuma, Y; Tsunoda, H | 1 |
| Freiche, JC; Lang, J; Sedivy, P; Touraine, JL | 1 |
| Cavero, I; Floch, A | 1 |
| Goldstein, L; Musch, MW | 1 |
| Ando, M; Matsuura, S; Suginami, H | 1 |
| Imanishi, N; Komuro, Y; Morooka, S; Uchida, M | 1 |
| Cox, CP | 1 |
| Holzer, P; Lippe, IT | 1 |
| Goswami, SK; Marom, ZM; Ohashi, M; Stathas, P | 1 |
| Hsueh, W; Sun, XM | 1 |
| Dufy, B; Mollard, P; Schlegel, W; Vacher, P; Winiger, BP | 1 |
| Ferracin, F; Gurari-Rotman, D; Pletscher, A | 1 |
| Abraham, WM; Ahmed, A; Garrido, R; Stevenson, JS; Tomioka, K | 1 |
| Chiang, CF; Hauser, G | 1 |
| Fouque, F; Parini, A; Schattner, M; Touqui, L; Vargaftig, BB | 1 |
| Breddin, HK; Weichert, W | 1 |
| Bittner, C; Lambrecht, G; Parnham, MJ | 1 |
| Cavero, I; Durand, G; Floch, A; James, C; Lave, D; Le Fur, G; Mondot, S; Pacot, D; Robaut, C; Sedivy, P | 1 |
| Dale, MM; Penfield, A | 1 |
| Becker, EL; Gomez-Cambronero, J; Molski, TF; Sha'afi, RI | 1 |
| Hwang, SB | 1 |
| Cavero, I; Marquis, O; Robaut, C | 1 |
| Benveniste, J; Coëffier, E; Desquand, S; Floch, A; Lefort, J; Maridonneau-Parini, I; Randon, J; Sedivy, P; Vargaftig, BB | 1 |
| Fukuzawa, K; Takauchi, K; Terao, M; Tokumura, A; Tsukatani, H; Yoshida, J | 1 |
| Hayashi, M; Kimura, J; Nomura, H; Oh-Ishi, S; Tsushima, S | 1 |
| Bozza, PT; Cordeiro, RS; Dias, PM; Faria Neto, HC; Lima, MC; Martins, MA; Silva, PM; Vargaftig, BB | 1 |
| Andres, G; Brentjens, J; Camussi, G; Pawlowski, I; Saunders, R | 1 |
| Anderson, RC; Handley, DA; Saunders, RN | 1 |
| Imura, Y; Nishikawa, K; Terashita, Z | 2 |
| Hayashi, H; Inoue, K; Kudo, I; Nojima, S; Nomura, H; Onozaki, K; Tsushima, S | 1 |
| Beattie, TR; Biftu, T; Hwang, SB; Lam, MH; Shen, TY | 1 |
| Imura, Y; Nishikawa, K; Sumida, S; Terashita, Z | 2 |
| Tokumura, A; Tsukatani, H | 1 |
| Deacon, RW; Farley, C; Handley, DA; Saunders, RN | 1 |
| Flury, S; Handley, DA; Lee, ML; Melden, MK; Saunders, RN; Van Valen, RG | 1 |
| Chang, SW; Henson, PM; McMurtry, IF; Pfeffer, KD; Voelkel, NF; Worthen, SG | 1 |
| Hwang, SB; Lam, MH | 1 |
| Bureau, M; Joseph, D; Vargaftig, BB | 1 |
| Benveniste, J; Braquet, P; Chignard, M; Korth, R; Le Couedic, JP; Norel, X; Nunez, D; Spinnewyn, B | 1 |
| Fest, W; Söling, HD | 1 |
| Adnot, S; Joseph, D; Vargaftig, BB | 1 |
| Imura, Y; Nishikawa, K; Shino, A; Terashita, Z | 1 |
| Hayashi, Y; Hirasawa, N; Ohuchi, K; Sugidachi, A; Tsurufuji, S; Watanabe, M | 1 |
| Braquet, P; Neuwirth, R; Satriano, JA; Schlondorff, D; Singhal, P | 1 |
| Dechavanne, M; Hanss, M | 1 |
| Myers, AK; Nakanishi, T; Ramwell, P | 1 |
| Camussi, G; Milgrom, F; Niesen, N; Saunders, RN; Tetta, C | 1 |
| Lagente, V; Steel, G; Vargaftig, B; Wallace, JL; Whittle, BJ | 1 |
| Adachi, M; Imai, T; Kamiya, I; Kobayashi, H; Nishikata, H; Okazawa, A; Satoh, H; Takahashi, T; Yamaguchi, H | 1 |
| Barnes, PJ; Birke, FW; Dent, G; Robaut, C; Sybrecht, GW; Ukena, D | 1 |
| Grue-Sørensen, G; Nielsen, CK; Nielsen, IM | 1 |
| Cirino, M; Desquand, S; Hadvary, P; Lagente, V; Lefort, J; Lellouch-Tubiana, A; Vargaftig, BB | 1 |
| Beijer, L; Burrell, R; Lantz, RC; Rylander, R; Sedivy, P | 1 |
| Bray, MA; Steiger, J; Subramanian, N | 1 |
| Hayashi, M; Oh, S; Yamaki, K | 1 |
| Steel, G; Wallace, JL; Whittle, BJ | 1 |
| Hahn, HL; Hansen, D; Lang, M | 1 |
| Chang, SW; Feddersen, CO; Henson, PM; Voelkel, NF | 1 |
| Knee, CD; Krell, RD; Kusner, EJ | 1 |
| Malo, PE; Pfeiffer, DF; Wasserman, MA | 1 |
| Fukuzawa, K; Okasaka, N; Tokumura, A; Tsukatani, H; Yoshida, J | 1 |
| Cox, CP; Wood, KL | 1 |
| Fukuzawa, K; Maruyama, T; Tokumura, A; Tsukatani, H; Yoshida, J | 1 |
| Baggiolini, M; Dewald, B | 1 |
| Genovese, A; Levi, R; Robertson, DA | 1 |
| Robertson, DN; Smith, GM | 1 |
| Wallace, JL; Whittle, BJ | 1 |
| Handley, DA; Saunders, RN; Van Valen, RG | 1 |
| Buxton, DB; Hanahan, DJ; Olson, MS | 1 |
| Kobayashi, T; Kubo, K; Kusama, S; Toyofuku, T | 1 |
| Anderson, RC; Arroyave, JL; Gonzalez-Crussi, F; Houlihan, WJ; Hsueh, W; Lee, ML | 1 |
| Harris, KE; Houlihan, WJ; Lee, ML; Patterson, R | 1 |
| Alloatti, G; Benedetto, C; Camussi, G; Emanuelli, G; Massobrio, M; Montrucchio, G; Roffinello, C; Tetta, C | 1 |
| Alloatti, G; Camussi, G; Emanuelli, G; Montrucchio, G; Roffinello, C; Tetta, C | 1 |
| Mikulaschek, AW; Toth, PD | 1 |
| Oda, M; Saito, K; Satouchi, K; Yasunaga, K | 1 |
| Hayashi, M; Nomura, H; Oh-ishi, S; Tsushima, S; Yamaki, K | 1 |
| Hanahan, DJ; Homma, H; Tokumura, A | 1 |
| Kogo, H; Matsudaira, T; Satoh, T | 1 |
| Shukla, SD | 1 |
| Issekutz, AC; Szpejda, M | 1 |
| Valone, FH | 1 |
| Handley, DA; Lee, ML; Saunders, RN | 1 |
| Kumahara, Y; Masugi, F; Ogihara, T; Otsuka, A; Saeki, S | 2 |
| Inada, Y; Nishikawa, K; Nomura, H; Terashita, Z; Tsushima, S; Yoshioka, Y | 1 |
| Akutsu, I; Fukuda, T; Makino, S; Motojima, S; Numao, T; Toda, M | 1 |
| Aglietta, M; Arese, M; Bussolino, F; Camussi, G; Costamagna, C; Garbarino, G; Pescarmona, G; Sanavio, F; Silvagno, F; Soldi, R | 1 |
| Alkon, DL; Inoue, H; Kouchi, T; Sakakibara, M; Yoshioka, T | 1 |
| Fang, G; Fonteles, M; Guerrant, RL; Thielman, NM; Yotseff, PS | 1 |
| Arima, M; Fukuda, T; Makino, S; Manaka, K | 1 |
| Dol, F; Herbert, JM; Laplace, MC; Mares, AM | 1 |
| Bado, A; Braquet, P; Laigneau, JP; Lewin, MJ; Moizo, L; Sobhani, I; Tarrade, T | 1 |
| Arima, M; Makino, S; Yukawa, T | 1 |
| Cooper, K; Fray, MJ; Parry, MJ; Richardson, K; Steele, J | 1 |
| Bousseau, A; Fauci, AS; Poli, G; Weissman, D | 1 |
| Asakura, K; Narita, S | 2 |
| Leduc, D; Pretolani, M; Vargaftig, BB; Zuany-Amorim, C | 1 |
| Albert, DH; Carter, GW; Conway, RG; Davidsen, SK; Holms, JH; Luo, G; Magoc, TJ; Rhein, DA; Summers, JB; Tapang, P | 2 |
| Heard, SO; Perkins, M; Toth, I | 1 |
| Inagami, T; Inui, H; Kitami, Y; Kondo, T; Konishi, F | 1 |
| Bewtra, AK; Eda, R; Gillen, MS; Hopp, RJ; Townley, RG | 1 |
| Cashin, C; Newbold, P; O'Donnell, M; Renzetti, L; Simko, B; Tocker, J; Wasserman, MA; Welton, AF | 1 |
| Imanishi, N; Koike, H; Morooka, S; Natsume, Y | 2 |
| Chand, N; Harrison, JE; Sofia, RD | 1 |
| Au, BT; Hellewell, PG; Rossi, AG; Teixeira, MM; Williams, TJ | 1 |
| Dikshit, M; Kumari, R; Seth, P; Srimal, RC | 1 |
| Bird, IN; Daniels, RH; Elmore, MA; Finnen, MJ; Hill, ME | 1 |
| Fang, GD; Fonteles, MC; Guerrant, RL; Thielman, NM | 1 |
| Bertagnolo, V; Borgatti, P; Capitani, S; Mazzoni, M; Osti, F; Previati, M | 1 |
| Connolly, RJ; Dinarello, CA; Dirkes, K; Gelfand, JA; Harris, BH; Schwaitzberg, SD | 1 |
| Bures, MG; Carrera, GM; Davidsen, SK; Guinn, DE; Heyman, HR; May, PD; Phillips, JG; Pireh, D; Sheppard, GS; Steinman, DH | 1 |
| Bernat, A; Herbert, JM | 1 |
| Imanishi, N; Koike, H; Morooka, S; Murakami-Uchida, M; Natsume, Y | 1 |
| Momose, K; Nobe, K; Ohata, H | 1 |
| Bachy, A; Fraisse, L; Herbert, JM; Keane, PE; Lale, A; Laplace, MC; Lassalle, J; Roche, B; Savi, P; Valette, G | 1 |
| DeJoy, SQ; Jeyaseelan, R; Kerwar, SS; Oronsky, AL; Pickett, WC; Torley, LW; Wick, MM; Wissner, A | 1 |
| Boonen, GJ; de Koster, BM; Elferink, JG | 1 |
| Gay, JC | 1 |
| Dougherty, R; Johnston, P; Pickett, W; Tao, W | 1 |
| Kester, M | 1 |
| Cailleau, C; Herbert, JM; Laplace, MC; Maffrand, JP | 1 |
| Jacobs, M; Pires, JG; Ramage, AG | 1 |
| Bon, C; Faili, A; Hatmi, M; Mounier, C; Vargaftig, BB | 1 |
| Bourdon, V; Damas, J; Remacle-Volon, G | 1 |
| Aosasa, S; Kinoshita, M; Mochizuki, H; Oda, Y; Ohe, H; Ohkusa, Y; Ono, S; Tamakuma, S | 1 |
| Calvello, C; Klabunde, RE | 1 |
| Itoh, K; Itoh, S; Kamataki, T; Kimura, K; Nunoya, K; Yokoi, T | 1 |
| Albert, DH; Carter, GW; Grossman, JE; Kruse-Elliott, KT; Summers, JB; Zimmerman, JJ | 1 |
| Liang, G; Shi, H; Xu, H | 1 |
| Giudice, A; Herbert, JM; Le Fur, G; Maffrand, JP; Manara, L; Manzoni, L | 1 |
| Bourgain, R; Decuyper, K; van Rossem, K; Vermariën, H | 1 |
| Johno, M; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Uchiba, M | 1 |
| Burt, RP; Chapple, CR; Marshall, I | 1 |
| Obata, Y; Oda, M; Yamamoto, N; Yokota, K | 1 |
| Chignard, M; Paulin, D; Renesto, P; Vicart, P | 1 |
| Albert, DH; Carter, GW; Davidsen, SK; Holms, JH; Luo, G; Magoc, TJ; Summers, JB; Tapang, P | 1 |
| Bernat, A; Corseaux, D; Herbert, JM; Lale, A | 1 |
| Hilger, RA; Köller, M; König, W | 2 |
| Packham, MA; Rand, ML; Ruben, DH | 1 |
| Bernat, A; Herbert, JM; Tibiriça, E | 1 |
| Avdi, NJ; Gerwins, P; Johnson, GL; Knall, C; Nick, JA; Worthen, GS; Young, SK | 1 |
| Bae, SJ; Hakugawa, J; Katayama, I; Tanaka, Y; Vinuesa, MA | 1 |
| Fang, GD; Guerrant, RL; Marcinkiewicz, M; Sarosiek, J; Thielman, NM | 1 |
| Morooka, S; Natsume, Y | 1 |
| Albert, DH; Carter, GW; Kleinert, HD; Magoc, TJ; Reyes, AE; Summers, JB; Sun, E | 1 |
| Chen, J; Giris, N | 1 |
| Barnes, PJ; Cluzel, M; Evans, DJ; O'Connor, BJ | 1 |
| Albert, DH; Carter, GW; Kleinert, HD; Magoc, TJ; Menacherry, SD; Morgan, DW; Reyes, AE; Summers, JB; Sun, E | 1 |
| Barbosa-Filho, JM; Castro-Faria-Neto, HC; Cordeiro, RS; Herbert, JM; Tibiriça, E | 1 |
| Hara, H; Mase, T; Matsuhisa, A; Nagaoka, H; Saito, M; Suzuki, T; Takahashi, T; Takeuchi, M; Tomioka, K; Yamada, T | 1 |
| Akiyama, M; Ino, M; Miwa, M; Shimura, M; Sugatani, J; Suzuki, M; Suzuki, Y; Yamazaki, R | 1 |
| Lefferts, PL; Lu, W; Snapper, JR; Thabes, JS | 1 |
| Bruyneel, E; Chastre, E; Gespach, C; Kotelevets, L; Mareel, M; Myssiakine, E; Noë, V | 1 |
| Barberà, JA; Chung, KF; Gómez, FP; Peinado, VI; Roca, J; Rodriguez-Roisin, R | 1 |
| Hamada, M; Hara, H; Kondo, Y; Mase, T; Nagaoka, H; Saito, M; Suzuki, T; Takahashi, T; Takeuchi, M; Tomioka, K; Yamada, T | 1 |
| Auchampach, JA; Cavero, I; Gross, GJ; Pieper, GM | 1 |
| Hawkey, CJ; Jenkins, D; Stack, WA; Vivet, P | 1 |
| Hood, AF; Morin, SM; Pei, Y; Travers, J | 1 |
| Higure, A; Itoh, H; Katoh, H; Nagafuchi, Y; Nakamura, S; Ohsato, K; Okamoto, K; Okazaki, K; Takeda, S; Todoroki, H | 1 |
| Hara, H; Mase, T; Matsumoto, H; Nagaoka, H; Saito, M; Suzuki, T; Takanuki, K; Takeuchi, M; Tomioka, K; Yamada, T | 1 |
| Barberà, JA; Chung, KF; Gómez, FP; Iglesia, R; Marrades, RM; Roca, J; Rodriguez-Roisin, RM | 1 |
| Berthou, C; Bourge, JF; Denizot, Y; Geromin, D; Sasportes, M; Sigaux, F; Soulié, A; Zhang, Y | 1 |
| Bensaid, O; Clayette, P; Dereuddre-Bosquet, N; Dong, CZ; Dormont, D; Godfroid, JJ; Heymans, F; Huet, J; Kan, E; Lamouri, A; Martin, M; Redeuilh, C; Serradji, N | 1 |
| Hayashi, J; Hiromura, K; Koizumi, R; Maezawa, A; Naruse, T; Nojima, Y; Shimizu, Y | 1 |
| Allaume, P; Cheminade, C; Gautier, V; Hichami, A; Le Lannou, D; Legrand, AB | 1 |
| Murakami, M; Murota, M; Oketani, K; Sakai, H; Suzuki, T; Takeguchi, N; Uchiumi, T | 1 |
| Attanasi, OA; Filippone, P; Giorgi, G; Salvini, L; Santeusanio, S | 1 |
| Chang, KH; Jeon, EJ; Kim, DH; Lee, SK; Park, YS; Yeo, SW | 1 |
| Bélanger, C; Borgeat, P; Elimam, H; Lefebvre, J; Marleau, S | 1 |
| Fang, W; Geng, X; Han, D; Li, Y; Lv, P; Sha, L; Shang, E; Wei, J; Yang, Q; Zhang, R | 1 |
1 review(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and thiazoles
| Article | Year |
|---|---|
[Antagonists of platelet activating factor].
Topics: Animals; Benzofurans; Benzopyrans; Depression, Chemical; Guinea Pigs; Lignans; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Thiazoles | 1985 |
7 trial(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and thiazoles
| Article | Year |
|---|---|
The effect of RP 59227, a platelet-activating factor antagonist, against antigen challenge and eosinophil and neutrophil chemotaxis in asthmatics.
Topics: Administration, Oral; Adult; Antigens; Asthma; Chemotaxis, Leukocyte; Cross-Over Studies; Double-Blind Method; Eosinophils; Humans; Male; Neutrophils; Platelet Activating Factor; Pyridines; Skin Tests; Thiazoles | 1994 |
Ex vivo inhibition of PAF-induced beta-thromboglobulin release in man by ABT-299, a potent PAF antagonist.
Topics: Adolescent; Adult; beta-Thromboglobulin; Chromatography, High Pressure Liquid; Double-Blind Method; Humans; Injections, Intravenous; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prodrugs; Pyridinium Compounds; Spectrophotometry, Ultraviolet; Thiazoles | 1996 |
Effects of a potent platelet-activating factor antagonist, SR27417A, on allergen-induced asthmatic responses.
Topics: Adult; Allergens; Asthma; Cross-Over Studies; Double-Blind Method; Forced Expiratory Volume; Humans; Male; Platelet Activating Factor; Thiazoles | 1997 |
Ex vivo inhibition of beta-thromboglobulin release following administration to man of ABT-299, a novel prodrug of a potent platelet activating factor antagonist.
Topics: Adolescent; Adult; beta-Thromboglobulin; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Double-Blind Method; Humans; In Vitro Techniques; Indoles; Injections, Intravenous; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prodrugs; Pyridinium Compounds; Thiazoles | 1997 |
Effect of a platelet-activating factor (PAF) antagonist, SR 27417A, on PAF-induced gas exchange abnormalities in mild asthma.
Topics: Adult; Airway Resistance; Asthma; Blood Gas Analysis; Female; Humans; Leukocyte Count; Male; Neutrophils; Platelet Activating Factor; Pulmonary Gas Exchange; Thiazoles | 1998 |
Lack of effectiveness of the platelet-activating factor antagonist SR27417A in patients with active ulcerative colitis: a randomized controlled trial. The Platelet Activating Factor Antagonist Study Group in Ulcerative Colitis.
Topics: Adult; Colitis, Ulcerative; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Activating Factor; Thiazoles | 1998 |
Gas exchange response to a PAF receptor antagonist, SR 27417A, in acute asthma: a pilot study.
Topics: Acute Disease; Adult; Airway Resistance; Asthma; Blood Flow Velocity; Blood Gas Analysis; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Pilot Projects; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Pulmonary Circulation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Ventilation-Perfusion Ratio | 1999 |
212 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and thiazoles
| Article | Year |
|---|---|
Platelet-activating factor provokes release of mucin-like glycoproteins from guinea pig respiratory epithelial cells via a lipoxygenase-dependent mechanism.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Epithelium; Glyceryl Ethers; Guinea Pigs; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; Mucins; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Trachea | 1992 |
Characterization of specific binding sites of 3H-labelled platelet-activating factor ([3H]PAF) and a new antagonist, [3H]SR 27417, on guinea-pig tracheal epithelial cells.
Topics: Animals; Binding Sites; Cells, Cultured; Epithelial Cells; Epithelium; Guinea Pigs; Kinetics; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Trachea; Tritium | 1992 |
Characterization of the antagonist activity of the PAF antagonists RP 59227 and WEB 2086 on elicited guinea pig peritoneal macrophages. Evidence for variable affinities and kinetics.
Topics: Animals; Azepines; Guinea Pigs; Humans; Kinetics; Macrophages; Male; Neutrophils; Peritoneum; Platelet Activating Factor; Pyridines; Superoxides; Thiazoles; Triazoles | 1992 |
Ex vivo effects of SR 27417, a novel PAF antagonist, on rabbit platelet aggregation and [3H]-PAF binding.
Topics: Administration, Oral; Animals; Blood Platelets; Dose-Response Relationship, Drug; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Statistics as Topic; Thiazoles | 1992 |
Cytokines and platelet-activating factor in human inflamed colonic mucosa.
Topics: Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Anti-Idiotypic; Calcimycin; Colitis, Ulcerative; Colon; Crohn Disease; Humans; Imidazoles; Immunoglobulin E; Interleukin-1; Intestinal Mucosa; Mesalamine; Organ Culture Techniques; Platelet Activating Factor; Prednisolone; Sulfasalazine; Thiazoles | 1992 |
A 5-lipoxygenase inhibitor, FR110302, suppresses airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles in rats.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chromones; Dextrans; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Indomethacin; Leukotriene B4; Lipoxygenase Inhibitors; Male; Microspheres; Naphthols; Platelet Activating Factor; Prednisolone; Pulmonary Eosinophilia; Pyridines; Quinolines; Rats; Rats, Inbred Strains; SRS-A; Thiazoles | 1992 |
Protective effect of SR 27417, a novel PAF antagonist, on PAF- or endotoxin-induced hypotension in the rat and the guinea-pig.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Endotoxins; Guinea Pigs; Hypotension; Injections, Intravenous; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Thiazoles | 1992 |
Effect of SR 27417 on oedema formation induced in rabbit skin by platelet-activating factor or antigen.
Topics: Allergens; Animals; Antigens; Edema; Injections, Intravenous; Male; Ovalbumin; Platelet Activating Factor; Rabbits; Skin Diseases; Thiazoles | 1992 |
Studies of the effect of a platelet-activating factor antagonist, CL 184,005, in animal models of gram-negative bacterial sepsis.
Topics: Animals; Blood Pressure; Female; Gram-Negative Bacterial Infections; Humans; Hypotension; Interleukin-6; Macaca fascicularis; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Organophosphorus Compounds; Permeability; Platelet Activating Factor; Rabbits; Rats; Rats, Wistar; Thiazoles; Tumor Necrosis Factor-alpha | 1992 |
Burn-induced gastric mucosal hemodynamic disturbance in the rat. Role of platelet-activating factor.
Topics: Animals; Azepines; Blood Pressure; Burns; Gastric Mucosa; Hemodynamics; Hemoglobins; Male; Oxygen; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Inbred Strains; Regional Blood Flow; Thiazoles; Thiazolidines; Triazoles | 1992 |
Platelet activating factor antagonist RP-59227 reduces vascular injury in discordant cardiac xenograft rejection.
Topics: Animals; Graft Rejection; Graft Survival; Guinea Pigs; Heart Transplantation; Male; Platelet Activating Factor; Pyridines; Rats; Rats, Inbred Lew; Thiazoles; Transplantation, Heterologous | 1992 |
RP 59227, a novel PAF receptor antagonist: effects in guinea pig models of airway hyperreactivity.
Topics: Animals; Antigens; Azepines; Bronchial Hyperreactivity; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Guinea Pigs; Male; Ovalbumin; Platelet Activating Factor; Pyridines; Thiazoles; Triazoles | 1992 |
Platelet-activating factor (PAF) plays an important role in the immediate asthmatic response in guinea-pig by augmenting the response to histamine.
Topics: Anaphylaxis; Animals; Asthma; Bronchi; Guinea Pigs; Histamine; Male; Ovalbumin; Platelet Activating Factor; Platelet Count; Pyridinium Compounds; Respiratory Function Tests; SRS-A; Thiazoles; Thiazolidines | 1992 |
Inhibition by glaucocalyxin A of aggregation of rabbit platelets induced by ADP, arachidonic acid and platelet-activating factor, and inhibition of [3H]-PAF binding.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Blood Platelets; Diterpenes, Kaurane; Drugs, Chinese Herbal; Female; Glyceryl Ethers; In Vitro Techniques; Kinetics; Male; Molecular Structure; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thiazoles | 1992 |
The platelet activating factor receptor antagonist, RP 59227, blocks platelet activating factor receptors mediating liberation of reactive oxygen species in guinea pig macrophages and human polymorphonuclear leukocytes.
Topics: Animals; Azepines; Glyceryl Ethers; Guinea Pigs; Humans; Luminescent Measurements; Macrophages; Male; Neutrophils; Oxygen; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles | 1991 |
Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist.
Topics: Animals; Azepines; Blood Platelets; Bronchoconstriction; Guinea Pigs; Humans; Injections, Intravenous; Leukopenia; Male; Mice; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thrombocytopenia; Triazoles | 1991 |
Pharmacological properties of YM461, a new orally active platelet-activating factor antagonist.
Topics: Administration, Oral; Animals; Azepines; Blood Platelets; Blood Pressure; Cell Membrane; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Male; Mice; Mice, Inbred ICR; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines; Triazoles | 1991 |
Inhibitory effects of a platelet activating factor-antagonist 48740RP in cyclosporin-induced nephrotoxicity in the rat as assessed by renal glutathione metabolism parameters.
Topics: Aminopeptidases; Animals; Blood Urea Nitrogen; CD13 Antigens; Creatinine; Cyclosporine; Glutathione; Kidney; Kidney Cortex; Platelet Activating Factor; Pyridines; Rats; Thiazoles | 1991 |
Ro 19-3704 directly inhibits immunoglobulin E-dependent mediator release by a mechanism independent of its platelet-activating factor antagonist properties.
Topics: Animals; Azepines; Diterpenes; Ginkgolides; Glyceryl Ethers; Histamine Release; Humans; Immunoglobulin E; Inositol Phosphates; L-Lactate Dehydrogenase; Lactones; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Substance P; Synovial Fluid; Thiazoles; Triazines; Triazoles; Tumor Cells, Cultured | 1990 |
Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on substance P-induced histamine release from rat peritoneal mast cells.
Topics: Animals; Ascitic Fluid; Calcium; Cyclohexanones; Female; Histamine Release; In Vitro Techniques; Male; Mast Cells; Platelet Activating Factor; Pyrimidinones; Rats; Rats, Inbred Strains; Substance P; Tetradecanoylphorbol Acetate; Thiazoles | 1990 |
Inhibition of ex-vivo PAF-induced platelet aggregation by the PAF-antagonist RP 48740: relationship to plasma concentrations in healthy volunteers.
Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Humans; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyridines; Reference Values; Thiazoles | 1991 |
Protective effect of SR 27417, a novel PAF antagonist, on lethal anaphylactic and endotoxin-induced shock in mice.
Topics: Anaphylaxis; Animals; Azepines; Dose-Response Relationship, Drug; Endotoxins; Escherichia coli; Male; Mice; Mice, Inbred Strains; Ovalbumin; Platelet Activating Factor; Shock, Septic; Thiazoles; Triazoles | 1991 |
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 1. Effect on passive anaphylactic bronchoconstriction in guinea pigs.
Topics: Anaphylaxis; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Male; Ovalbumin; Platelet Activating Factor; Propranolol; Pyrilamine; SRS-A; Thiazoles; Thiazolidines | 1991 |
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 2. Effect on antigen-induced dual asthmatic response and infiltration of leukocytes into airways in actively sensitized conscious guinea pigs.
Topics: Animals; Antigens; Asthma; Cromolyn Sodium; Disease Models, Animal; Fenoterol; Guinea Pigs; Leukocytes; Lung; Male; Ovalbumin; Platelet Activating Factor; Respiratory Function Tests; Respiratory System; Thiazoles; Thiazolidines | 1991 |
The effects of R-75,317 on antiglomerular basement membrane glomerulonephritis in rats.
Topics: Acetylglucosaminidase; Animals; Basement Membrane; Biomarkers; Blood Pressure; Creatinine; Female; Glomerulonephritis; Immune Sera; Isoxazoles; Kidney; Kidney Glomerulus; Platelet Activating Factor; Proteinuria; Rats; Rats, Inbred Strains; Thiazoles | 1991 |
Effects of PAF antagonists on renal vascular escape and tachyphylaxis in perfused rabbit kidney.
Topics: Animals; Azepines; Diterpenes; Female; Gangliosides; Ginkgolides; In Vitro Techniques; Kidney; Kinetics; Lactones; Male; Perfusion; Platelet Activating Factor; Pyridines; Rabbits; Renal Circulation; Tachyphylaxis; Thiazoles; Time Factors; Triazoles | 1991 |
Effect of a selective PAF antagonist SM-10661 ((+/-)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one HCl) on experimental disseminated intravascular coagulation (DIC).
Topics: Administration, Oral; Animals; Disseminated Intravascular Coagulation; Endotoxins; Fibrin Fibrinogen Degradation Products; Fibrinogen; Gabexate; Infusions, Intravenous; Injections, Intraperitoneal; Partial Thromboplastin Time; Platelet Activating Factor; Platelet Count; Prothrombin Time; Rats; Thiazoles; Thiazolidines | 1991 |
Induction of platelet-activating factor in mice by intravenous administration of a neutral fraction of bakers' yeast mannan.
Topics: Albuterol; Animals; Bile; Blood Pressure; Chromatography, Ion Exchange; Hypotension; Mannans; Mice; Mice, Inbred Strains; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rabbits; Saccharomyces cerevisiae; Thiazoles | 1991 |
Phosphatidic acid accumulation and catecholamine release in adrenal chromaffin cells: stimulation by high potassium and by nicotine, and effect of a diacylglycerol kinase inhibitor R 59 022.
Topics: Animals; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Dose-Response Relationship, Drug; Nicotine; Phosphatidic Acids; Platelet Activating Factor; Potassium; Pyrimidinones; Thiazoles | 1991 |
Alkaline buffers release EDRF from bovine cultured aortic endothelial cells.
Topics: Animals; Arginine; Buffers; Cattle; Cells, Cultured; Cyclohexanones; Endothelium, Vascular; Epoprostenol; Hydrogen-Ion Concentration; Lipoprotein Lipase; Nitric Oxide; omega-N-Methylarginine; Platelet Activating Factor; Pyrimidinones; Thiazoles | 1991 |
Platelet-leukocyte interaction in adhesion to endothelial cells induced by platelet-activating factor in vitro.
Topics: Adenine; Animals; Azepines; Blood Platelets; Cell Adhesion; Diterpenes; Endothelium, Vascular; Female; Ginkgolides; Humans; In Vitro Techniques; Lactones; Leukocytes; Neutrophils; Platelet Activating Factor; Platelet Adhesiveness; Pregnancy; Rabbits; Thiazoles; Triazoles; Umbilical Veins | 1991 |
PAF-induced conjunctivitis in the rabbit is mediated by peptido-leukotrienes.
Topics: Animals; Azepines; Conjunctiva; Conjunctivitis; Cyclooxygenase Inhibitors; Dicarboxylic Acids; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Indomethacin; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Rabbits; Second Messenger Systems; Tetrazoles; Thiazoles; Thienopyridines; Triazoles | 1990 |
Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat.
Topics: Animals; Azepines; Disease Models, Animal; Glomerulonephritis, Membranous; Hypercholesterolemia; Male; Metabolic Clearance Rate; Methylprednisolone; Piperazines; Platelet Activating Factor; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Ticlopidine; Triazoles | 1991 |
The role of platelet-activating factor in the pulmonary response to inhaled bacterial endotoxin.
Topics: Animals; Blood Volume; Capillaries; Capillary Permeability; Cricetinae; Endothelium, Vascular; Endotoxins; Enterobacter; Leukocyte Count; Lung; Lung Volume Measurements; Male; Mesocricetus; Platelet Activating Factor; Platelet Count; Pulmonary Alveoli; Pulmonary Edema; Pyridines; Thiazoles | 1991 |
Selective implication of thromboxane A2 and PAF-acether in two guinea pig anaphylactic models.
Topics: Anaphylaxis; Animals; Antigens; Glyceryl Ethers; Guinea Pigs; Immunoglobulin E; Immunoglobulin G; In Vitro Techniques; Indomethacin; Muscle Contraction; Platelet Activating Factor; Thiazoles; Thromboxane A2; Trachea | 1990 |
Platelet activating factor and tracheobronchial respiratory glycoconjugate release in feline and human explants: involvement of the lipoxygenase pathway.
Topics: Animals; Bronchi; Cats; Culture Techniques; Glyceryl Ethers; Glycoconjugates; Humans; Ibuprofen; Lipoxygenase; Masoprocol; Platelet Activating Factor; Thiazoles; Trachea; Tritium | 1990 |
Binding of radiolabeled antagonist to platelet-activating-factor receptor in human lung membranes: shifting of agonist binding affinity states by cations and guanine nucleotide.
Topics: Binding, Competitive; Cations; Guanine Nucleotides; Humans; Lung; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles | 1990 |
Regulation of oxytocin secretion by the ovine corpus luteum: effect of activators of protein kinase C.
Topics: Animals; Bucladesine; Calcimycin; Corpus Luteum; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Female; In Vitro Techniques; Oxytocin; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Sheep; Tetradecanoylphorbol Acetate; Thiazoles; Type C Phospholipases | 1990 |
Synergism between platelet-activating factor and diacylglycerol in the induction of superoxide anion production in guinea pig polymorphonuclear leukocytes.
Topics: Animals; Diglycerides; Drug Synergism; Drug Therapy, Combination; Glycerides; Guinea Pigs; Neutrophils; Oxygen; Platelet Activating Factor; Superoxides; Thiazoles; Virulence Factors, Bordetella | 1990 |
Muscarinic receptor antagonist activity of diacylglycerol lipase and kinase inhibitors.
Topics: Animals; Brain; Cells, Cultured; Cyclic GMP; Cyclohexanes; Cyclohexanones; Guinea Pigs; Heart; Lipoprotein Lipase; Myocardium; N-Methylscopolamine; Pancreas; Parasympatholytics; Platelet Activating Factor; Pyrimidinones; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Thiazoles; Tritium | 1990 |
Characterization of receptors for platelet-activating factor in guinea pig lung membranes.
Topics: Animals; Azepines; Cell Membrane; Female; Guinea Pigs; Kinetics; Lung; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles | 1990 |
Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Survival; Chloroquine; Diltiazem; Drug Synergism; Endocytosis; Furans; Humans; Hydroxyzine; In Vitro Techniques; Leukemia, Myeloid; Mice; Nifedipine; Phospholipid Ethers; Platelet Activating Factor; Pyridines; Quinidine; Quinine; Sodium Fluoride; Thiazoles; Triazoles; Verapamil | 1990 |
Involvement of leukotriene C4 in PAF-induced death in mice.
Topics: Acetophenones; Animals; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid; Lipoxygenase Inhibitors; Male; Mice; Platelet Activating Factor; SRS-A; Tetrazoles; Thiazoles | 1990 |
Prolonged survival of renal transplants in nonimmunized and hyperimmunized rats receiving a platelet-activating factor antagonist.
Topics: Animals; Cyclosporins; Cytotoxicity, Immunologic; Graft Rejection; Immunization; Kidney Transplantation; Male; Platelet Activating Factor; Pyridines; Rats; Rats, Inbred BN; Rats, Inbred Lew; Survival Rate; Thiazoles | 1990 |
Influence of plasma protein content and platelet number on the potency of PAF and its antagonist RP 59227 in rabbit platelet preparations.
Topics: Animals; Blood Proteins; In Vitro Techniques; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Pyridines; Rabbits; Thiazoles | 1990 |
Hypotonicity stimulates phosphatidylcholine hydrolysis and generates diacylglycerol in erythrocytes.
Topics: Animals; Diglycerides; Erythrocytes; Glycerides; Hydrolysis; Hypotonic Solutions; In Vitro Techniques; Kinetics; Phosphates; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylethanolamines; Platelet Activating Factor; Pyrimidinones; Skates, Fish; Thiazoles | 1990 |
Pregnancy suppression by a platelet activating factor antagonist, ONO-6240, in mice.
Topics: Animals; Blastocyst; Female; Litter Size; Male; Mice; Mice, Inbred ICR; Platelet Activating Factor; Pregnancy; Pregnancy, Animal; Thiazoles | 1990 |
Biological effect of orally active platelet-activating factor receptor antagonist SM-10661.
Topics: Administration, Oral; Animals; Blood Pressure; Bronchi; Guinea Pigs; Humans; Male; Mice; Mice, Inbred ICR; Platelet Activating Factor; Platelet Aggregation; Rabbits; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1990 |
Effects of CV-3988, an antagonist of platelet-activating factor (PAF), on washed rabbit platelets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Platelets; Calcimycin; Collagen; Cyclic AMP; Dose-Response Relationship, Drug; Epoprostenol; Female; Osmolar Concentration; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thiazoles | 1986 |
The diacylglycerol kinase inhibitor, R 59022, suppresses contractility of intestinal smooth muscle.
Topics: Acetylcholine; Animals; Calcium; Diacylglycerol Kinase; Female; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phosphatidylinositols; Phosphotransferases; Platelet Activating Factor; Pyrimidinones; Substance P; Thiazoles | 1989 |
Platelet-activating factor stimulates secretion of respiratory glycoconjugate from human airways in culture.
Topics: Arachidonic Acids; Atropine; Bronchi; Culture Techniques; Cyclooxygenase Inhibitors; Dexamethasone; Dose-Response Relationship, Drug; Glyceryl Ethers; Glycoconjugates; Histamine Release; Humans; Leukotrienes; Lipoxygenase Inhibitors; Mucous Membrane; Platelet Activating Factor; Thiazoles; Time Factors | 1989 |
Tumor necrosis factor-induced bowel necrosis: the role of platelet-activating factor.
Topics: Animals; Drug Synergism; Intestines; Leukopenia; Lipopolysaccharides; Male; Necrosis; Platelet Activating Factor; Rats; Rats, Inbred Strains; Recombinant Proteins; Thiazoles; Tumor Necrosis Factor-alpha | 1989 |
Inhibitors of 1,2-diacylglycerol kinase potentiate the TRH-induced stimulation of Ca2+-activated K+ current.
Topics: Calcium; Calcium Channels; Clone Cells; Diacylglycerol Kinase; Phosphotransferases; Platelet Activating Factor; Potassium Channels; Pyrimidinones; Thiazoles; Thyrotropin-Releasing Hormone; Vanadates | 1989 |
LDL induced shape change reaction of platelets is not due to PAF.
Topics: Azepines; Blood Platelets; Glyceryl Ethers; Humans; In Vitro Techniques; Lipoproteins, LDL; Platelet Activating Factor; Thiazoles; Thienopyridines; Triazolam | 1989 |
YM461, a PAF antagonist, blocks antigen-induced late airway responses and airway hyperresponsiveness in allergic sheep.
Topics: Aerosols; Animals; Antigens; Ascaris; Carbachol; Dose-Response Relationship, Drug; Platelet Activating Factor; Pyridines; Respiratory Hypersensitivity; Sheep; Thiazoles; Thiazolidines | 1989 |
Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells.
Topics: Animals; Bradykinin; Cell Line; Drug Interactions; Ethylmaleimide; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hybrid Cells; Inositol; Inositol Phosphates; Kinetics; Mice; Neuroblastoma; Platelet Activating Factor; Pyrimidinones; Rats; Thiazoles; Thionucleotides | 1989 |
Selective inhibition of adrenaline-induced human platelet aggregation by the structurally related Paf antagonist Ro 19-3704.
Topics: 5-Hydroxytryptophan; Binding, Competitive; Diterpenes; Drug Synergism; Epinephrine; Ginkgolides; Glyceryl Ethers; Humans; In Vitro Techniques; Lactones; Morpholines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Thiazoles; Yohimbine | 1989 |
A PAF-acether antagonist (N 48740 RP/Rhône-Poulenc) and laser-induced thrombi in rat mesenteric vessels.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Lasers; Male; Mesenteric Arteries; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyridines; Rats; Rats, Inbred Strains; Thiazoles; Thrombosis | 1989 |
Antagonism of platelet activating factor-induced chemiluminescence in guinea-pig peritoneal macrophages in differing states of activation.
Topics: Alprazolam; Animals; Benzofurans; Diterpenes; Furans; Ginkgolides; Guinea Pigs; In Vitro Techniques; Lactones; Lignans; Luminescent Measurements; Macrophage Activation; Macrophages; Male; Platelet Activating Factor; Thiazoles | 1989 |
PAF binding sites. Characterization by [3H]52770 RP, a pyrrolo[1,2-c]thiazole derivative, in rabbit platelets.
Topics: Animals; Blood Platelets; Diterpenes; Furans; Ginkgolides; In Vitro Techniques; Kinetics; Lactones; Male; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Pyridines; Rabbits; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Stereoisomerism; Thiazoles; Triazolam; Tritium | 1987 |
Comparison of the effects of indomethacin, RHC80267 and R59022 on superoxide production by 1,oleoyl-2,acetyl glycerol and A23187 in human neutrophils.
Topics: Angiotensin-Converting Enzyme Inhibitors; Calcimycin; Cyclohexanes; Cyclohexanones; Diglycerides; Glycerides; Humans; In Vitro Techniques; Indomethacin; Kinetics; Neutrophils; Platelet Activating Factor; Pyrimidinones; Superoxides; Thiazoles | 1987 |
The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cytochalasin B; Diacylglycerol Kinase; Isoquinolines; Kinetics; Leupeptins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Phosphotransferases; Piperazines; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rabbits; Superoxides; Thiazoles | 1987 |
Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes.
Topics: Blood Platelets; Calcium; Cations; Cell Aggregation; Cell Membrane; Cholera Toxin; GTP Phosphohydrolases; Humans; Lithium; Magnesium; Neutrophils; Pertussis Toxin; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Potassium; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sodium; Thiazoles; Virulence Factors, Bordetella | 1988 |
[3H]52770 RP, a platelet-activating factor receptor antagonist, and tritiated platelet-activating factor label a common specific binding site in human polymorphonuclear leukocytes.
Topics: Binding Sites; Binding, Competitive; Humans; In Vitro Techniques; Kinetics; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Stereoisomerism; Thiazoles; Tritium | 1988 |
Pharmacological profile of 48740 R.P., a PAF-acether antagonist.
Topics: Animals; Blood Cell Count; Blood Platelets; Bronchodilator Agents; Guinea Pigs; Humans; In Vitro Techniques; Macrophages; Male; Muscle Contraction; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Perfusion; Platelet Activating Factor; Platelet Aggregation; Pulmonary Alveoli; Pyridines; Rabbits; Radioimmunoassay; Superoxides; Thiazoles; Thromboxane B2 | 1988 |
A platelet-aggregating and hypotensive phospholipid isolated from bovine brain.
Topics: Animals; Blood Pressure; Brain Chemistry; Cattle; Diazomethane; In Vitro Techniques; Phospholipid Ethers; Phospholipids; Platelet Activating Factor; Platelet Aggregation; Rabbits; Rats; Rats, Inbred Strains; Thiazoles | 1986 |
Characterization of the activity of a platelet activating factor antagonist, CV-3988.
Topics: Alprazolam; Animals; Autacoids; Blood Pressure; Capillary Permeability; Dose-Response Relationship, Drug; Male; Phospholipid Ethers; Platelet Activating Factor; Rabbits; Rats; Rats, Inbred Strains; Skin; Thiazoles | 1987 |
Pharmacological modulation of Paf-induced rat pleurisy and its role in inflammation by zymosan.
Topics: Animals; Azepines; Carrageenan; Leukocyte Count; Male; Platelet Activating Factor; Pleurisy; Pyridines; Rats; Rats, Inbred Strains; Thiazoles; Triazines; Triazoles; Zymosan | 1989 |
Receptor antagonist of platelet activating factor inhibits inflammatory injury induced by in situ formation of immune complexes in renal glomeruli and in the skin.
Topics: Animals; Arthus Reaction; Complement System Proteins; Female; Fluorescent Antibody Technique; Glomerulonephritis; Histocytochemistry; Immune Complex Diseases; Immunoglobulin G; Platelet Activating Factor; Rats; Rats, Inbred Lew; Thiazoles | 1987 |
Inhibition by SRI 63-072 and SRI 63-119 of PAF-acether and immune complex effects in the guinea pig.
Topics: Administration, Oral; Animals; Antigen-Antibody Complex; Arthus Reaction; Guinea Pigs; Injections, Intravenous; Platelet Activating Factor; Stereoisomerism; Thiazoles | 1987 |
Inhibition by CV-3988 of the binding of [3H]-platelet activating factor (PAF) to the platelet.
Topics: Animals; Blood Platelets; Depression, Chemical; Guinea Pigs; Humans; In Vitro Techniques; Male; Mice; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin; Species Specificity; Thiazoles; Tritium | 1985 |
Activation of guinea pig peritoneal macrophages by platelet activating factor (PAF) and its agonists.
Topics: Animals; Blood Platelets; Female; Guinea Pigs; In Vitro Techniques; Macrophages; Peritoneal Cavity; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 1985 |
trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor.
Topics: Animals; Benzofurans; Benzopyrans; Blood Platelets; Bradykinin; Capillary Permeability; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Furans; Histamine; Humans; Lignans; Magnesium; Mathematics; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sodium; Thiazoles | 1985 |
Beneficial effects of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate, a specific PAF antagonist, in endotoxin and anaphylactic shock.
Topics: Anaphylaxis; Animals; Blood Platelets; Hypotension; Mice; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock, Septic; Thiazoles | 1985 |
Evidence for distinct systemic extravasation effects of platelet activating factor, leukotrienes B4, C4, D4 and histamine in the guinea pig.
Topics: Animals; Chromones; Diphenhydramine; Dose-Response Relationship, Drug; Guinea Pigs; Hematocrit; Hemorrhage; Histamine; Injections, Intravenous; Leukotriene B4; Male; Phospholipid Ethers; Plasma; Platelet Activating Factor; SRS-A; Thiazoles; Time Factors | 1986 |
Inhibition and reversal of endotoxin-, aggregated IgG- and paf-induced hypotension in the rat by SRI 63-072, a paf receptor antagonist.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Endotoxins; Hot Temperature; Hypotension; Immunoglobulin G; Macromolecular Substances; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles | 1986 |
PAF antagonists: different effects on platelets, neutrophils, guinea pig ileum and PAF-induced vasodilation in isolated rat lung.
Topics: Alprazolam; Angiotensin II; Animals; Blood Platelets; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; Muscle Contraction; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pulmonary Artery; Pulmonary Circulation; Rabbits; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin; SRS-A; Thiazoles; Vasodilation | 1986 |
Species difference in the specific receptors of platelet activating factor.
Topics: Animals; Benzofurans; Blood Platelets; Cell Membrane; Diterpenes; Furans; Ginkgolides; Humans; Lactones; Lignans; Lung; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Species Specificity; Thiazoles; Thiophenes | 1986 |
Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether.
Topics: Animals; Cells, Cultured; Cytochalasin B; Diterpenes; Exocytosis; Ginkgolides; Glucuronidase; Lactones; Leukotriene B4; Male; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Plant Extracts; Platelet Activating Factor; Pyridines; Rats; Rats, Inbred Strains; Thiazoles | 1987 |
Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Benzofurans; Benzopyrans; Blood Platelets; Diterpenes; Ginkgolides; Humans; In Vitro Techniques; Lactones; Lignans; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Thiazoles | 1986 |
Synthesis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in exocrine glands and its control by secretagogues.
Topics: Acetates; Acetic Acid; Animals; Calcimycin; Carbachol; Ceruletide; Cholecystokinin; Exocrine Glands; Exocytosis; Extracellular Space; Guinea Pigs; Male; Platelet Activating Factor; Platelet Aggregation; Thiazoles; Tissue Distribution | 1986 |
Antagonists of PAF-acether do not suppress thrombin-induced aggregation of ADP-deprived and aspirin-treated human platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Blood Platelets; Crotalid Venoms; Cyclooxygenase Inhibitors; Diterpenes; Ginkgolides; Glyceryl Ethers; Humans; Lactones; Lectins, C-Type; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Pyridines; Thiazoles; Thrombin | 1987 |
A lethal role of platelet activating factor in anaphylactic shock in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromones; Dexamethasone; Male; Mice; Mice, Inbred Strains; Naloxone; Phospholipid Ethers; Platelet Activating Factor; Pyrazoles; SRS-A; Thiazoles | 1987 |
Platelet-activating factor in the inflammatory exudate in the anaphylactic phase of allergic inflammation in rats.
Topics: Adenosine Diphosphate; Anaphylaxis; Animals; Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Exudates and Transudates; Inflammation; Male; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rats; Rats, Inbred Strains; Thiazoles | 1987 |
Effect of platelet activating factor antagonists on cultured rat mesangial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzofurans; Calcimycin; Cells, Cultured; Dinoprostone; Diterpenes; Dose-Response Relationship, Drug; Ginkgolides; Glomerular Mesangium; Lactones; Lignans; Male; Plant Extracts; Platelet Activating Factor; Prostaglandins E; Rats; Thiazoles | 1987 |
48740 RP, an antagonist of PAF, does not affect human plasma fibrinolysis before and after venous occlusion.
Topics: Adult; Constriction; Fibrinolysis; Humans; In Vitro Techniques; Male; Platelet Activating Factor; Pyridines; Thiazoles; Tissue Plasminogen Activator; Veins | 1988 |
Antagonism of PAF-induced death in mice.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Diterpenes; Epinephrine; Fatty Acids, Unsaturated; Furans; Ginkgolides; Hydrazines; Lactones; Male; Mice; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Pyridines; Thiazoles; Thromboxane A2 | 1988 |
Release of platelet-activating factor from rabbit heart perfused in vitro by sera with transplantation alloantibodies.
Topics: Animals; Coronary Circulation; Female; Graft Rejection; Heart; Heart Rate; Isoantibodies; Perfusion; Platelet Activating Factor; Rabbits; Skin Transplantation; Thiazoles | 1987 |
Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat. Effects of three platelet-activating factor antagonists.
Topics: Animals; Blood Pressure; Disease Models, Animal; Diterpenes; Escherichia coli Infections; Ethanol; Ginkgolides; Glyceryl Ethers; Intestine, Small; Lactones; Lipopolysaccharides; Male; Peptic Ulcer; Peptic Ulcer Hemorrhage; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Rats; Rats, Inbred Strains; Shock, Septic; Stomach; Thiazoles | 1987 |
[The effect of a specific antagonist of PAF (CV-3988) on airway hyperresponsiveness induced by ozone exposure in beagles].
Topics: Animals; Bronchi; Dogs; Female; Methacholine Chloride; Methacholine Compounds; Ozone; Phospholipid Ethers; Platelet Activating Factor; Thiazoles; Thromboxane B2 | 1987 |
Radioligand binding of antagonists of platelet-activating factor to intact human platelets.
Topics: Azepines; Binding Sites; Binding, Competitive; Blood Platelets; Humans; Kinetics; Platelet Activating Factor; Pyridines; Thiazoles; Triazines; Triazoles; Tritium | 1988 |
Derivatives of 2-methylenepropane-1,3-diol as new antagonists of platelet activating factor.
Topics: Animals; Blood Pressure; Bronchi; Female; Guinea Pigs; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Pyridinium Compounds; Rabbits; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiazoles | 1988 |
Interference of the Paf antagonist Ro 19-3704 with Paf and antigen-induced bronchoconstriction in the guinea-pig.
Topics: Aerosols; Animals; Blood Cell Count; Bronchodilator Agents; Female; Glyceryl Ethers; Guinea Pigs; In Vitro Techniques; Macrophage Activation; Macrophages; Male; Ovalbumin; Phospholipid Ethers; Platelet Activating Factor; Pulmonary Alveoli; Thiazoles | 1988 |
Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP).
Topics: Administration, Inhalation; Animals; Capillary Permeability; Cricetinae; Endothelium, Vascular; Endotoxins; Female; Guinea Pigs; Male; Platelet Activating Factor; Pneumonia; Pyridines; Thiazoles | 1988 |
Platelet activating factor (PAF) is a potent stimulator of porcine tracheal fluid secretion in vitro.
Topics: Animals; Body Fluids; In Vitro Techniques; Muscle, Smooth; Phospholipid Ethers; Platelet Activating Factor; Swine; Thiazoles; Trachea | 1987 |
Inflammatory effects of acetylglycerylether phosphorylcholine: vascular permeability increase and induction of pleurisy in rats.
Topics: Animals; Azo Compounds; Bradykinin; Capillary Permeability; Dexamethasone; Guinea Pigs; Histamine; Indomethacin; Inflammation; Injections; Leukocyte Count; Male; Methysergide; Phospholipid Ethers; Platelet Activating Factor; Pleural Effusion; Pleurisy; Prostaglandins; Pyrilamine; Rabbits; Rats; Rats, Inbred Strains; Serotonin; Skin; Skin Physiological Phenomena; Thiazoles; Trypan Blue | 1986 |
Gastrointestinal plasma leakage in endotoxic shock. Inhibition by prostaglandin E2 and by a platelet-activating factor antagonist.
Topics: Animals; Blood Pressure; Blood Proteins; Digestive System; Dinoprostone; Male; Phospholipid Ethers; Platelet Activating Factor; Prostaglandins E; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Shock, Septic; Thiazoles | 1987 |
Effects of the PAF-antagonist CV-3988 on PAF-induced changes in mucus secretion and in respiratory and circulatory variables in ferrets.
Topics: Animals; Asthma; Blood Cells; Ferrets; Mucus; Phospholipid Ethers; Platelet Activating Factor; Thiazoles | 1987 |
Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats.
Topics: Animals; Blood Pressure; Endotoxins; Hemodynamics; Lung; Male; Neutropenia; Phospholipid Ethers; Platelet Activating Factor; Pulmonary Circulation; Quinolinium Compounds; Rats; Rats, Inbred Strains; Salmonella enteritidis; Thiazoles; Time Factors; Vasoconstriction; Vinblastine | 1987 |
Pharmacologic analysis of 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced increases in cutaneous vascular permeability in the rat.
Topics: Animals; Capillary Permeability; Chromones; Dose-Response Relationship, Drug; Indomethacin; Masoprocol; Methysergide; Nifedipine; Phenoxybenzamine; Phospholipid Ethers; Platelet Activating Factor; Pyrilamine; Rats; Theophylline; Thiazoles | 1987 |
Enhancement of leukotriene D4-induced contraction of guinea-pig isolated trachea by platelet activating factor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Airway Resistance; Animals; Guinea Pigs; In Vitro Techniques; Male; Meclofenamic Acid; Phospholipid Ethers; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; SRS-A; Thiazoles; Trachea | 1987 |
Platelet aggregation induced by ether-linked phospholipids. 2. Mechanism of desensitization of rabbit platelets by platelet activating factor and reversibility of inhibitory actions of its antagonists.
Topics: Animals; In Vitro Techniques; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rabbits; Serum Albumin, Bovine; Structure-Activity Relationship; Thiazoles | 1987 |
Selective antagonism of platelet-activating factor (PAF)-induced aggregation and secretion in washed rabbit platelets by CV-3988, L-652731, triazolam and alprazolam.
Topics: Alprazolam; Animals; Blood Platelets; Furans; In Vitro Techniques; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rabbits; Serotonin; Thiazoles; Triazolam | 1987 |
Platelet aggregation induced by ether-linked phospholipids. 1. Inhibitory actions of bovine serum albumin and structural analogues of platelet activating factor.
Topics: Animals; Cats; Cattle; Ethers; Humans; Lysophospholipids; Phosphatidic Acids; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rabbits; Serum Albumin, Bovine; Structure-Activity Relationship; Thiazoles | 1987 |
Evaluation of PAF antagonists using human neutrophils in a microtiter plate assay.
Topics: Benzofurans; Diterpenes; Exocytosis; Fluorescence; Ginkgolides; Humans; Lactones; Lignans; Methods; Neutrophils; Pancreatic Elastase; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Pyridines; Thiazoles | 1987 |
Negative inotropic effect of platelet-activating factor on human myocardium: a pharmacological study.
Topics: Calcium; Depression, Chemical; Dose-Response Relationship, Drug; Humans; Indomethacin; Myocardial Contraction; Phospholipid Ethers; Platelet Activating Factor; Quinolinium Compounds; SRS-A; Thiazoles | 1987 |
CV3988 inhibits in vivo platelet aggregation induced by PAF-acether and collagen.
Topics: Animals; Blood Pressure; Collagen; Male; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Count; Rabbits; Rats; Species Specificity; Thiazoles; Thromboxane B2; Time Factors | 1986 |
Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor.
Topics: Animals; Blood Pressure; Endotoxins; Lipopolysaccharides; Male; Peptic Ulcer; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Salmonella typhi; Thiazoles | 1986 |
Vascular responses of platelet-activating factor in the Cebus apella primate and inhibitory profiles of antagonists SRI 63-072 and SRI 63-119.
Topics: Animals; Cebus; Indomethacin; Lung; Macaca mulatta; Male; Papio; Platelet Activating Factor; Platelet Aggregation; Thiazoles; Thrombocytopenia; Thromboxane B2 | 1986 |
Possible role of platelet activating factor (PAF) in disseminated intravascular coagulation (DIC), evidenced by use of a PAF antagonist, CV-3988.
Topics: Animals; Disseminated Intravascular Coagulation; Endotoxins; Phospholipid Ethers; Platelet Activating Factor; Rats; Thiazoles | 1986 |
Specific antagonists of platelet activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver.
Topics: Animals; Dose-Response Relationship, Drug; Glucose; Liver; Liver Glycogen; Male; Perfusion; Phenylephrine; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rats; Rats, Inbred Strains; Thiazoles; Vasoconstriction; Venous Pressure | 1986 |
Effects of ONO-6240, a platelet-activating factor antagonist, on endotoxin shock in unanesthetized sheep.
Topics: Animals; Blood Pressure; Cardiac Output; Endotoxins; Hemodynamics; Leukocyte Count; Lung; Lymph; Oxygen; Platelet Activating Factor; Platelet Count; Sheep; Shock, Septic; Thiazoles; Vascular Resistance | 1986 |
Platelet activating factor-induced ischemic bowel necrosis: the effect of PAF antagonists.
Topics: Animals; Body Weight; Hematocrit; Intestine, Small; Ischemia; Lipopolysaccharides; Male; Necrosis; Platelet Activating Factor; Rats; Rats, Inbred Strains; Splanchnic Circulation; Thiazoles | 1986 |
Inhibition of rhesus monkey airway and cutaneous responses to platelet-activating factor (PAF) (AGEPC) with the anti-PAF agent SRI 63-072.
Topics: Aerosols; Animals; Female; Hypersensitivity, Immediate; Macaca mulatta; Male; Platelet Activating Factor; Respiratory Function Tests; Respiratory System; Skin; Thiazoles | 1986 |
Platelet-activating factor contracts human myometrium in vitro.
Topics: Adult; Chromones; Female; Humans; In Vitro Techniques; Myometrium; Oxytocin; Phospholipid Ethers; Platelet Activating Factor; Pregnancy; Thiazoles; Uterine Contraction | 1986 |
In vitro contractile effect of platelet-activating factor on guinea-pig myometrium.
Topics: Animals; Chromones; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Myometrium; Oxytocin; Phospholipid Ethers; Platelet Activating Factor; Prostaglandins; Thiazoles; Uterine Contraction | 1986 |
Effects of a platelet-activating factor antagonist, CV-3988, on different shock models in the rat.
Topics: Animals; Blood Pressure; Decerebrate State; Male; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Shock; Shock, Hemorrhagic; Shock, Septic; Thiazoles | 1986 |
Polymorphonuclear leukocyte-platelet interactions: acetylglyceryl ether phosphocholine-induced platelet activation under stimulation with chemotactic peptide.
Topics: Animals; Blood Platelets; Masoprocol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thiazoles | 1986 |
Suppression of phorbol myristate acetate-induced pleurisy by CV-3988, an antagonist of platelet-activating factor.
Topics: Animals; Male; Phospholipid Ethers; Platelet Activating Factor; Pleurisy; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thiazoles | 1986 |
Structural analogs of alkylacetylglycerophosphocholine inhibitory behavior on platelet activation.
Topics: Animals; Blood Platelets; Kinetics; Phosphatidic Acids; Phosphatidylinositols; Phospholipid Ethers; Phospholipids; Platelet Activating Factor; Platelet Aggregation; Rabbits; Serotonin; Thiazoles | 1985 |
A possible role of antihypertensive polar renomedullary lipid (APRL) and prostaglandin E2 in the kidney in the antihypertensive action of pindolol.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dinoprostone; Electrolytes; Indomethacin; Kidney; Male; Phospholipid Ethers; Pindolol; Platelet Activating Factor; Prostaglandins E; Rats; Rats, Inbred SHR; Thiazoles | 1985 |
Platelet activating factor-stimulated formation of inositol triphosphate in platelets and its regulation by various agents including Ca2+, indomethacin, CV-3988, and forskolin.
Topics: Animals; Blood Platelets; Calcium; Colforsin; Diterpenes; Dose-Response Relationship, Drug; Indomethacin; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Models, Biological; Phospholipid Ethers; Platelet Activating Factor; Rabbits; Sugar Phosphates; Thiazoles; Time Factors | 1985 |
Evidence that platelet activating factor may mediate some acute inflammatory responses. Studies with the platelet-activating factor antagonist, CV3988.
Topics: Acute Disease; Animals; Blood Platelets; Capillary Permeability; Cell Movement; Inflammation; Leukocytes; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutropenia; Phospholipid Ethers; Platelet Activating Factor; Rabbits; Regional Blood Flow; Serum Albumin; Skin; Thiazoles; Thrombocytopenia | 1986 |
Inhibition of binding of the platelet-activating factor AGEPC to platelets by the AGEPC analog rac-3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl 2-thiazolioethyl phosphate (CV-3988).
Topics: Blood Platelets; Dose-Response Relationship, Drug; Humans; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Thiazoles | 1985 |
Is platelet activating factor (PAF) a mediator of endotoxin shock?
Topics: Animals; Blood Pressure; Endotoxins; Male; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Shock, Septic; Thiazoles | 1985 |
Evidence for a direct effect on vascular permeability of platelet-activating factor induced hemoconcentration in the guinea pig.
Topics: Animals; Calcium Channel Blockers; Capillary Permeability; Guinea Pigs; Hematocrit; Histamine; Male; Phospholipid Ethers; Platelet Activating Factor; Thiazoles; Thromboxane-A Synthase | 1985 |
The role of antihypertensive polar renomedullary lipid in the pathogenesis of hypertension.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Dinoprostone; Dogs; Epoprostenol; Female; Histamine; Hypertension, Renal; Kidney; Kidney Medulla; Male; Norepinephrine; Phospholipid Ethers; Platelet Activating Factor; Prostaglandins E; Rats; Rats, Inbred Strains; Thiazoles | 1984 |
CV-3988 - a specific antagonist of platelet activating factor (PAF).
Topics: Adenosine Diphosphate; Alprostadil; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Calcimycin; Collagen; Dose-Response Relationship, Drug; Male; Micelles; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Prostaglandins E; Rabbits; Rats; Rats, Inbred Strains; Thiazoles | 1983 |
Effect of 1-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine inhibitor on the reduction of one-kidney, one clip hypertension after unclipping in the rat.
Topics: Animals; Blood Pressure; Hypertension, Renovascular; Male; Phospholipid Ethers; Platelet Activating Factor; Rats; Renal Artery; Thiazoles | 1984 |
Inhibition of leukotriene C4 and B4 release by human eosinophils with the new 5-lipoxygenase inhibitor 6-hydroxy-2(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazo le hydrochloride.
Topics: Asthma; Calcimycin; Dose-Response Relationship, Drug; Eosinophils; Humans; In Vitro Techniques; Ionophores; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Platelet Activating Factor; Thiazoles | 1995 |
Human endothelial cells are targets for platelet-activating factor (PAF). Activation of alpha and beta protein kinase C isozymes in endothelial cells stimulated by PAF.
Topics: Actins; Amino Acid Sequence; Antibodies; Cell Membrane; Cells, Cultured; Chromatography, Ion Exchange; Cytoskeletal Proteins; Cytosol; Diglycerides; Diterpenes; Endothelium, Vascular; Enzyme Activation; Ginkgolides; Humans; Isoenzymes; Kinetics; Lactones; Molecular Sequence Data; Naphthalenes; Peptides; Phospholipid Ethers; Platelet Activating Factor; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Thiazoles; Vinculin | 1994 |
Induction of photoresponse by the hydrolysis of polyphosphoinositides in the Hermissenda type B photoreceptor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Hydrolysis; Inositol 1,4,5-Trisphosphate; Kinetics; Lithium Chloride; Models, Biological; Neomycin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Photoreceptor Cells, Invertebrate; Platelet Activating Factor; Pyrimidinones; Snails; Spermine; Thiazoles; Thionucleotides; Type C Phospholipases | 1994 |
Role of platelet activating factor in the inflammatory and secretory effects of Clostridium difficile toxin A.
Topics: Actins; Animals; Bacterial Toxins; Enteritis; Enterotoxins; Epithelium; Ileum; Intestinal Mucosa; Intestines; Male; Phalloidine; Platelet Activating Factor; Rabbits; Rhodamines; Staining and Labeling; Thiazoles | 1995 |
Role of platelet-activating factor in the release of neutrophil and eosinophil chemotactic attractants from cultured guinea-pig tracheal epithelial cells.
Topics: Animals; Chemotactic Factors; Eosinophils; Epithelial Cells; Granulocyte-Macrophage Colony-Stimulating Factor; Guinea Pigs; Male; Neutrophils; Piperazines; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines; Trachea | 1995 |
Platelet-activating factor (PAF) is not an essential component of the cascade leading to smooth muscle cell proliferation following vascular injury.
Topics: Animals; Aorta; Cell Division; Endothelium, Vascular; Hyperplasia; Male; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thiazoles; Vascular Diseases | 1995 |
Platelet-activating factor stimulates gastric acid secretion in isolated rabbit gastric glands.
Topics: Aminopyrine; Animals; Azepines; Biological Transport; Calcium; Carbachol; Dose-Response Relationship, Drug; Egtazic Acid; Famotidine; Fluorescent Dyes; Gastric Acid; Gastric Mucosa; Histamine; In Vitro Techniques; Kinetics; Male; Platelet Activating Factor; Rabbits; Thiazoles; Thienopyridines; Triazoles; Verapamil | 1995 |
Effect of YM264 on the airway hyperresponsiveness and the late asthmatic response in a guinea pig model of asthma.
Topics: Aerosols; Airway Resistance; Analysis of Variance; Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Guinea Pigs; Immunization; Male; Ovalbumin; Piperazines; Platelet Activating Factor; Random Allocation; Statistics, Nonparametric; Thiazoles; Thiazolidines; Time Factors; Trachea | 1995 |
Novel antagonists of platelet-activating factor. 1. Synthesis and structure-activity relationships of benzodiazepine and benzazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine.
Topics: Animals; Azepines; Benzodiazepines; Imidazoles; Mice; Platelet Activating Factor; Pyridines; Rabbits; Structure-Activity Relationship; Thiazoles; Triazoles | 1995 |
A platelet-activating factor antagonist, RP 55778, inhibits cytokine-dependent induction of human immunodeficiency virus expression in chronically infected promonocytic cells.
Topics: Cell Line; Chloramphenicol O-Acetyltransferase; Cytokines; Fluorescent Antibody Technique; Granulocyte-Macrophage Colony-Stimulating Factor; HIV Reverse Transcriptase; HIV-1; Humans; Interleukin-6; Kinetics; Monocytes; Platelet Activating Factor; Pyridines; Recombinant Proteins; RNA Processing, Post-Transcriptional; RNA-Directed DNA Polymerase; RNA, Messenger; RNA, Viral; Tetradecanoylphorbol Acetate; Thiazoles; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha | 1993 |
The role of platelet-activating factor on histamine hypersensitivity in nasal allergy in guinea pig models.
Topics: Allergens; Animals; Guinea Pigs; Histamine Release; Hypersensitivity; Male; Ovalbumin; Platelet Activating Factor; Thiazoles; Thiazolidines | 1993 |
Characterization and pharmacological modulation of antigen-induced peritonitis in actively sensitized mice.
Topics: Animals; Benzeneacetamides; Cetirizine; Cycloheximide; Dexamethasone; Eosinophils; Histamine Release; Hydroxamic Acids; Indomethacin; Kinetics; Leukocyte Count; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Peritoneal Cavity; Peritonitis; Platelet Activating Factor; T-Lymphocytes; Tacrolimus; Terfenadine; Thiazoles; Zymosan | 1993 |
ABT-299, a potent antagonist of platelet activating factor.
Topics: Animals; Binding, Competitive; Blood Pressure; Edema; Esterases; Humans; Hypotension; Indoles; Kinetics; Lipopolysaccharides; Mice; Molecular Structure; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prodrugs; Pyridinium Compounds; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock, Septic; Thiazoles | 1995 |
The role of platelet-activating factor in lipopolysaccharide-induced myocardial depression in guinea pigs.
Topics: Animals; Azepines; Depression, Chemical; Drug Interactions; Escherichia coli; Female; Guinea Pigs; Isoproterenol; Lipopolysaccharides; Male; Myocardial Contraction; Phenylephrine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Quinolinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Time Factors; Triazoles | 1995 |
Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells.
Topics: Alkaloids; Analysis of Variance; Animals; Aorta, Thoracic; Arachidonic Acid; Becaplermin; Cell Division; Cells, Cultured; Diacylglycerol Kinase; DNA; Enzyme Activation; Genistein; Humans; Isoflavones; Mitogens; Muscle, Smooth, Vascular; Myristic Acid; Myristic Acids; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Pyrimidinones; Rats; Recombinant Proteins; Signal Transduction; Staurosporine; Thiazoles | 1994 |
Studies of the combination of Ro 24-5913, a peptidoleukotriene antagonist, and Ro 24-4736, a PAF antagonist, in guinea pig and rat models of lung inflammation.
Topics: Animals; Bronchoconstriction; Guinea Pigs; Lung; Male; Phenanthridines; Platelet Activating Factor; Pneumonia; Rats; SRS-A; Thiazoles; Triazines | 1994 |
Effect of the platelet activating factor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride on endotoxin-induced hypotension and hematological parameters in rats.
Topics: Animals; Blood Coagulation; Blood Pressure; Dose-Response Relationship, Drug; Endotoxins; Fibrin Fibrinogen Degradation Products; In Vitro Techniques; Iodine Radioisotopes; Male; Platelet Activating Factor; Platelet Count; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1994 |
Effect of PAF-antagonists on aeroallergen-induced bronchial eosinophilia in guinea pigs: a therapeutic approach.
Topics: Administration, Oral; Allergens; Animals; Asthma; Atmosphere Exposure Chambers; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Eosinophilia; Guinea Pigs; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Thiazoles | 1994 |
Characterization of eosinophil homotypic aggregation.
Topics: Animals; Calcium; CD18 Antigens; Cell Aggregation; Drug Synergism; Eosinophils; Guinea Pigs; Leukotriene B4; Magnesium; Microscopy; Platelet Activating Factor; Pyrimidinones; Stimulation, Chemical; Superoxides; Thiazoles | 1995 |
Effects of platelet activating factor receptor antagonists on intracellular platelet activating factor function in neutrophils.
Topics: Animals; Azepines; Binding, Competitive; Calcium; Cell Count; Cell Degranulation; Chemotaxis, Leukocyte; Free Radical Scavengers; Inositol 1,4,5-Trisphosphate; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridines; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reference Standards; Signal Transduction; Structure-Activity Relationship; Superoxides; Thiazoles; Thiazolidines; Triazoles; Vitamin E | 1994 |
Effect of platelet activating factor antagonists in different models of thrombosis.
Topics: Animals; Arterial Occlusive Diseases; Azepines; Cats; Diterpenes; Ginkgolides; Lactones; Male; Mice; Mice, Inbred Strains; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Thiazoles; Thrombophlebitis; Triazoles | 1994 |
The effects of anti-PAF and other agents on the nasal symptoms in sensitized guinea pigs.
Topics: Airway Resistance; Animals; Azepines; Chromones; Guinea Pigs; Histamine H1 Antagonists; Immunization; Lipoxygenase Inhibitors; Male; Ovalbumin; Phthalazines; Platelet Activating Factor; Pyrilamine; Rhinitis, Allergic, Perennial; Sneezing; SRS-A; Thiazoles; Thiazolidines; Triazoles | 1993 |
Endothelial cell-associated platelet-activating factor primes neutrophils for enhanced superoxide production and arachidonic acid release during adhesion to but not transmigration across IL-1 beta-treated endothelial monolayers.
Topics: Arachidonic Acid; Azepines; Cell Adhesion; Cell Movement; Cell Polarity; Endothelium, Vascular; Humans; In Vitro Techniques; Interleukin-1; Neutrophil Activation; Neutrophils; Piperazines; Platelet Activating Factor; Superoxides; Thiazoles; Thiazolidines; Triazoles | 1994 |
Role of platelet activating factor in the intestinal epithelial secretory and Chinese hamster ovary cell cytoskeletal responses to cholera toxin.
Topics: Animals; CHO Cells; Cholera Toxin; Cricetinae; Cytoskeleton; Diterpenes; Epithelium; Ginkgolides; Ileum; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Lactones; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles | 1994 |
Diacylglycerol kinase activity in rat liver nuclei.
Topics: Animals; Cell Nucleus; Detergents; Diacylglycerol Kinase; Enzyme Activation; Enzyme Inhibitors; Enzyme Stability; Liver; Male; Microsomes, Liver; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Pyrimidinones; Rats; Rats, Sprague-Dawley; Substrate Specificity; Thiazoles | 1994 |
Platelet activating factor-antagonist improves survival in experimental staphylococcal septicemia.
Topics: Animals; Hemodynamics; Leukocyte Count; Organophosphorus Compounds; Platelet Activating Factor; Platelet Count; Rabbits; Sepsis; Staphylococcal Infections; Staphylococcus epidermidis; Thiazoles | 1994 |
3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles, a novel series of platelet activating factor antagonists.
Topics: Administration, Oral; Animals; Capillary Permeability; Edema; In Vitro Techniques; Indoles; Magnetic Resonance Spectroscopy; Male; Mice; Platelet Activating Factor; Rabbits; Rats; Rats, Sprague-Dawley; Serotonin; Skin; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 1994 |
Effect of various drugs on adriamycin-enhanced venous thrombosis in the rat: importance of PAF.
Topics: Animals; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Doxorubicin; Leukocyte Count; Male; Platelet Activating Factor; Platelet Count; Rats; Rats, Sprague-Dawley; Thiazoles; Thrombophlebitis; Ticlopidine | 1994 |
Biological effects of the new platelet-activating factor receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride.
Topics: Anaphylaxis; Animals; Blood Platelets; Blood Pressure; Endotoxins; Guinea Pigs; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Stereoisomerism; Thiazoles; Thiazolidines | 1994 |
Effect of diacylglycerol kinase inhibitor, R59022 on cytosolic free calcium level and force development in guinea pig taenia coli.
Topics: Animals; Calcium; Colon; Guinea Pigs; Muscle Contraction; Platelet Activating Factor; Pyrimidinones; Thiazoles | 1993 |
Biochemical and pharmacological properties of SR 27388, a dual antioxidant and PAF receptor antagonist.
Topics: Animals; Antioxidants; Azepines; Blood Glucose; Blood Platelets; Cattle; Diabetes Mellitus, Experimental; Free Radical Scavengers; Humans; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Mitochondria, Heart; Monocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock, Septic; Superoxides; Sympathomimetics; Thiazoles; Thiobarbituric Acid Reactive Substances; Triazoles | 1993 |
Effect of CL 184,005, a platelet-activating factor antagonist in a murine model of Staphylococcus aureus-induced gram-positive sepsis.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enterotoxins; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Organophosphorus Compounds; Platelet Activating Factor; Staphylococcal Infections; Thiazoles; Time Factors; Tumor Necrosis Factor-alpha | 1994 |
Activation of neutrophil migration by dioctanoyl-sn-glycerol and fMet-Leu-Phe is controlled by different pathways.
Topics: Animals; Chemotaxis, Leukocyte; Diglycerides; Glyceryl Ethers; Guanosine 5'-O-(3-Thiotriphosphate); Macrophage Activation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rabbits; Thiazoles | 1993 |
Binding of [3H]SR 27417, a novel platelet-activating factor (PAF) receptor antagonist, to rabbit and human platelets and polymorphonuclear leukocytes.
Topics: Animals; Binding Sites; Binding, Competitive; Blood Platelets; Dose-Response Relationship, Drug; Humans; Male; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles | 1993 |
Mechanism and regulation of neutrophil priming by platelet-activating factor.
Topics: Adult; Amiloride; Azepines; Calcium; Chelating Agents; Diacylglycerol Kinase; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphotransferases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Pyrimidinones; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Tetradecanoylphorbol Acetate; Thiazoles; Triazoles; Type C Phospholipases; Virulence Factors, Bordetella | 1993 |
Recombinant bovine GM-CSF primes superoxide production but not degranulation induced by recombinant bovine interleukin-1 beta in bovine neutrophils.
Topics: Animals; Cattle; Cell Degranulation; Glucuronidase; Granulocyte-Macrophage Colony-Stimulating Factor; Interleukin-1; Neutrophils; Organophosphorus Compounds; Platelet Activating Factor; Recombinant Proteins; Superoxides; Thiazoles | 1993 |
Platelet-activating factor stimulates phosphatidic acid formation in cultured rat mesangial cells: roles of phospholipase D, diglyceride kinase, and de novo phospholipid synthesis.
Topics: Animals; Cells, Cultured; Choline; Diacylglycerol Kinase; Ethanolamines; Glomerular Mesangium; Glycerol; Hydrolysis; Male; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Phospholipids; Phosphorus Radioisotopes; Phosphotransferases; Platelet Activating Factor; Pyrimidinones; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors; Tritium | 1993 |
Effect of SR 27417 on the binding of [3H]PAF to rabbit and human platelets and human polymorphonuclear leukocytes.
Topics: Animals; Blood Platelets; Humans; Molecular Structure; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Tritium | 1993 |
ICI 169,369, A 5-HT2/5-HT1C antagonist, that can evoke endothelium-dependent relaxation in rabbit aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Endothelium, Vascular; In Vitro Techniques; Kinetics; Muscle Relaxation; Nitric Oxide; Platelet Activating Factor; Pyrimidinones; Quinolines; Rabbits; Serotonin Antagonists; Thiazoles; Vasodilator Agents | 1993 |
Competitive inhibition of phospholipase A2 activity by the platelet-activating factor antagonist Ro 19-3704 and evidence for a novel suppressive effect on platelet activation.
Topics: Animals; Arachidonic Acid; Blood Platelets; Glyceryl Ethers; Male; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Activation; Rabbits; Serum Albumin, Bovine; Thiazoles | 1993 |
Platelet-activating factor and the vascular effects of zymosan in rats.
Topics: Animals; Azepines; Blood Pressure; Capillary Permeability; Female; Hematocrit; Hemodynamics; Iodine Radioisotopes; Male; Muscle, Smooth, Vascular; Platelet Activating Factor; Rats; Rats, Wistar; Thiazoles; Thiazolidines; Triazoles; Zymosan | 1993 |
Clinical and experimental studies on the role of platelet-activating factor (PAF) in the pathogenesis of septic DIC.
Topics: Aged; Animals; Blood Pressure; Disseminated Intravascular Coagulation; Female; Fibrinolysis; Guanidines; Humans; Male; Middle Aged; Neoplasms; Platelet Activating Factor; Platelet Count; Postoperative Complications; Rabbits; Serine Proteinase Inhibitors; Shock, Septic; Thiazoles; Thiazolidines | 1993 |
Inhibition of endotoxin-induced microvascular leakage by a platelet-activating factor antagonist and 5-lipoxygenase inhibitor.
Topics: Analysis of Variance; Animals; Capillary Permeability; Cell Adhesion; Cheek; Cricetinae; Endothelium, Vascular; Furans; Leukocytes; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Methylurea Compounds; Microcirculation; Microscopy, Fluorescence; Platelet Activating Factor; Pyridinium Compounds; Shock, Septic; Thiazoles | 1995 |
Properties of ABT-299, a prodrug of A-85783, a highly potent platelet activating factor receptor antagonist.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Kinetics; Mice; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prodrugs; Pyridinium Compounds; Rabbits; Rats; Thiazoles | 1996 |
S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride by rat hepatic flavin-containing monooxygenase 1 expressed in yeast.
Topics: Animals; Hydrogen-Ion Concentration; Microsomes, Liver; Oxidation-Reduction; Oxygenases; Platelet Activating Factor; Rats; Recombinant Proteins; Saccharomyces cerevisiae; Thiazoles; Thiazolidines | 1995 |
Attenuation of endotoxin-induced pathophysiology by a new potent PAF receptor antagonist.
Topics: Animals; Blood Pressure; Cardiac Output; Dose-Response Relationship, Drug; Lipopolysaccharides; Lung; Peroxidase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prodrugs; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock, Septic; Stroke Volume; Swine; Thiazoles; Thromboxane B2; Vascular Resistance | 1996 |
[Effects of a platelet-activating factor antagonist ONO-6240 on antigen induced eosinophil infiltration into the airways].
Topics: Animals; Asthma; Blood Cell Count; Bronchoalveolar Lavage Fluid; Eosinophils; Female; Interleukin-2; Interleukin-5; Mice; Mice, Inbred BALB C; Platelet Activating Factor; Thiazoles | 1995 |
Prevention of platelet-activating factor-induced gastrointestinal lesions in rats by the new specific antagonist N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisopropylphe nyl) thiazol-2yl]amine.
Topics: Animals; Azepines; Dose-Response Relationship, Drug; Gastric Mucosa; Gastrointestinal Diseases; Intestinal Mucosa; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Thiazoles; Triazoles | 1996 |
The role of PAF and the effect of a specific PAF antagonist on local tissue PO2 and neuronal integrity during and after photothrombotic brain infarction in unanesthetised rabbits.
Topics: Animals; Brain; Cerebral Infarction; Disease Models, Animal; Evoked Potentials, Somatosensory; Male; Neurons; Oxygen Consumption; Photobiology; Platelet Activating Factor; Pyridines; Rabbits; Thiazoles; Time Factors | 1996 |
A novel platelet activating factor antagonist, SM-12502, attenuates endotoxin-induced disseminated intravascular coagulation and acute pulmonary vascular injury by inhibiting TNF production in rats.
Topics: Animals; Blood Coagulation; Disease Models, Animal; Disseminated Intravascular Coagulation; Endotoxins; Female; Humans; Infant, Newborn; Platelet Activating Factor; Pulmonary Artery; Rats; Rats, Wistar; Respiratory Distress Syndrome, Newborn; Thiazoles; Thiazolidines | 1996 |
The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens.
Topics: Animals; Calcium; Carcinogens; Cyclohexanones; Diglycerides; Lipoprotein Lipase; Male; Naphthalenes; Norepinephrine; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Staurosporine; Thiazoles; Vas Deferens | 1996 |
Inhibitory effects of the new anti-platelet agent KBT-3022 and its metabolite on rabbit neutrophil function in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Calcium; Cell Adhesion; Cilostazol; Complement C3-C5 Convertases; Complement C5a; Cyclooxygenase Inhibitors; Indomethacin; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Structure-Activity Relationship; Superoxides; Tetradecanoylphorbol Acetate; Tetrazoles; Thiazoles; Ticlopidine | 1996 |
Protective effect of platelet activating factor antagonists on cultured endothelial cell lysis induced by elastase or activated neutrophils.
Topics: Azepines; Cells, Cultured; Diterpenes; Dose-Response Relationship, Drug; Endothelium, Vascular; Ginkgolides; Humans; Lactones; Leukocyte Elastase; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles | 1996 |
ABT-299, a novel PAF antagonist, attenuates multiple effects of endotoxemia in conscious rats.
Topics: Animals; Consciousness; Disseminated Intravascular Coagulation; Endotoxemia; Endotoxins; Gastrointestinal Hemorrhage; Hypotension; Lipopolysaccharides; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Teichoic Acids; Thiazoles | 1996 |
Hypoxia primes endotoxin-induced tissue factor expression in human monocytes and endothelial cells by a PAF-dependent mechanism.
Topics: Animals; Cells, Cultured; Endotoxins; Humans; Hypoxia; Interleukin-1; Lipopolysaccharides; Monocytes; Platelet Activating Factor; Rabbits; Thiazoles; Thrombophlebitis; Thromboplastin; Umbilical Cord | 1996 |
Inhibition of leukotriene formation and IL-8 release by the paf-receptor antagonist SM-12502.
Topics: Aluminum; Basophils; Calcimycin; Calcium; Depression, Chemical; Gene Expression Regulation; GTP-Binding Proteins; Humans; Interleukin-8; Ionophores; Leukocytes, Mononuclear; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Sodium Fluoride; Thiazoles; Thiazolidines | 1996 |
Effect of the PAF-receptor antagonist SM-12502 on human platelets.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Aluminum; Arachidonate 12-Lipoxygenase; Calcimycin; Calcium; Fatty Acids, Unsaturated; Gene Expression Regulation; GTP-Binding Proteins; Humans; Ionophores; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prostaglandin-Endoperoxide Synthases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Sodium Fluoride; Thiazoles; Thiazolidines; Thrombin | 1996 |
Exogenous diacylglycerols synergize with PAF with human platelets, but inhibit PAF-induced responses of rabbit platelets.
Topics: Animals; Blood Platelets; Cell Membrane Permeability; Diacylglycerol Kinase; Diglycerides; Drug Synergism; Enzyme Inhibitors; Humans; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrimidinones; Rabbits; Thiazoles | 1996 |
Effect of SR 27417, a novel PAF antagonist on antigen-induced hypotension in the rat.
Topics: Animals; Antigens; Hypotension; Male; Ovalbumin; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Thiazoles | 1997 |
Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Chemotaxis; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Humans; Imidazoles; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphorylation; Platelet Activating Factor; Precipitin Tests; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Saccharomyces cerevisiae Proteins; Signal Transduction; Superoxides; Thiazoles; Time Factors; Virulence Factors, Bordetella | 1997 |
[The inhibitory effect of LTB4 antagonist on eosinophil infiltration in cutaneous and gut late phase response in BALB/C mice sensitized with ovalubumin (OVA)].
Topics: Animals; Cell Movement; Dermatitis, Atopic; Eosinophils; Female; Immunization; Immunosuppressive Agents; Intestines; Leukotriene B4; Mice; Mice, Inbred BALB C; Ovalbumin; Phenylpropionates; Platelet Activating Factor; Skin; Thiazoles | 1997 |
Role of platelet-activating factor in Chinese hamster ovary cell responses to cholera toxin.
Topics: Alprostadil; Animals; Bucladesine; Cell Size; CHO Cells; Cholera Toxin; Cricetinae; Cyclic AMP; Cycloheximide; Dactinomycin; Dinoprostone; Diterpenes; Ginkgolides; Humans; Lactones; Phospholipases A; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Synthesis Inhibitors; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles | 1997 |
Effect of SM-12502 on disseminated intravascular coagulation (DIC) in tumor-bearing rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Disseminated Intravascular Coagulation; Injections, Intravenous; Liver Neoplasms, Experimental; Male; Neoplasm Transplantation; Platelet Activating Factor; Rats; Rats, Wistar; Thiazoles; Thiazolidines; Time Factors; Tumor Cells, Cultured | 1996 |
Species differences in PAF receptor binding in the lungs between hamster and guinea pig.
Topics: Animals; Azepines; Binding, Competitive; Cricetinae; Fibrinolytic Agents; Guinea Pigs; Kinetics; Ligands; Lung; Male; Mesocricetus; Organophosphorus Compounds; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Species Specificity; Thiazoles; Triazoles | 1997 |
Pharmacological evidence for the putative existence of two different subtypes of PAF receptors on platelets and leukocytes; studies with yangambin.
Topics: Animals; Blood Platelets; Furans; Guinea Pigs; Humans; Interleukin-1; Interleukin-6; Kinetics; Leukocytes; Leukopenia; Lignans; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Burst; Thiazoles; Thrombocytopenia; Tumor Necrosis Factor-alpha | 1997 |
2-(3-Pyridyl)thiazolidine-4-carboxamides. 1. Novel orally active antagonists of platelet-activating factor (PAF).
Topics: Animals; Capillary Permeability; Guinea Pigs; Hematocrit; Humans; Mice; Piperazines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridines; Rabbits; Rats; Rats, Wistar; Species Specificity; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1997 |
Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets.
Topics: Animals; Azepines; Blood Platelets; Humans; In Vitro Techniques; Kinetics; Neutrophils; P-Selectin; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines; Triazoles | 1998 |
Effect of platelet-activating factor-receptor antagonism on endotoxin-induced lung dysfunction in sheep.
Topics: Animals; Blood Pressure; Endotoxins; Humans; Infant, Newborn; Leukocyte Count; Lung; Oxygen; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prodrugs; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Distress Syndrome, Newborn; Respiratory Function Tests; Sheep; Thiazoles | 1998 |
Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion.
Topics: Androstadienes; Animals; Azepines; Cell Adhesion Molecules; Cell Movement; Chromones; Colonic Neoplasms; Dogs; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Genes, src; GTP-Binding Proteins; Hepatocyte Growth Factor; Humans; Intestinal Mucosa; Kidney; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Thiazoles; Transformation, Genetic; Triazoles; Tumor Cells, Cultured; Virulence Factors, Bordetella; Wortmannin | 1998 |
2-(3-Pyridyl)thiazolidine-4-carboxamide derivatives. II. Structure-activity relationships and active configuration of 2-(3-pyridyl)thiazolidine-4-carboxamides as platelet-activating factor receptor antagonists.
Topics: Animals; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyridines; Rabbits; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1998 |
Effect of the platelet-activating factor antagonist RP 59227 (Tulopafant) on myocardial ischemia/reperfusion injury and neutrophil function.
Topics: Animals; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Female; Free Radicals; Incidence; Male; Myocardial Infarction; Myocardial Ischemia; Myocardium; Neutrophils; Peroxidase; Platelet Activating Factor; Pyridines; Reperfusion Injury; Thiazoles; Ventricular Fibrillation | 1998 |
Antiinflammatory activity of the platelet-activating factor receptor antagonist A-85783.
Topics: Animals; Anti-Inflammatory Agents; Ear; Indoles; Inflammation; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Skin; Thiazoles | 1998 |
Possible role of platelet-activating factor in the in vivo expression of tissue factor in neutrophils.
Topics: Animals; Aspartate Aminotransferases; Blood Coagulation; Cholangitis; Disease Models, Animal; Leukocytes; Liver; Male; Neutrophils; Platelet Activating Factor; Rabbits; Thiazoles; Thiazolidines; Thromboplastin | 1998 |
2-(3-Pyridyl)thiazolidine-4-carboxamide derivatives. III.) Synthesis of metabolites and metabolism of 2-(3-pyridyl)thiazolidine-4-carboxamides YM461 and YM264 as platelet-activating factor (PAF) receptor antagonists.
Topics: Administration, Oral; Animals; Area Under Curve; Biotransformation; Chromatography, High Pressure Liquid; Dogs; In Vitro Techniques; Injections, Intravenous; Macaca mulatta; Male; Piperazines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridines; Rabbits; Rats; Rats, Inbred F344; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines | 1999 |
Interferon-gamma-induced membrane PAF-receptor expression confers tumor cell susceptibility to NK perforin-dependent lysis.
Topics: Adult; Azepines; Calcium; Cell Membrane; Cytotoxicity, Immunologic; Gene Expression; Humans; Interferon-gamma; Killer Cells, Natural; Membrane Glycoproteins; Neoplasms; Perforin; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pore Forming Cytotoxic Proteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Transfection; Triazoles; Tumor Cells, Cultured | 2000 |
Structure-activity relationships in platelet-activating factor (PAF). 10. From PAF antagonism to inhibition of HIV-1 replication.
Topics: Anti-HIV Agents; Cells, Cultured; HIV; Humans; In Vitro Techniques; Inhibitory Concentration 50; Macrophages; Microbial Sensitivity Tests; Piperazines; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Thiazoles; Virus Replication | 2000 |
Platelet-activating factor antagonist, SM-12502, attenuates experimental glomerular thrombosis in rats.
Topics: Animals; Fibrin; Kidney Glomerulus; Lipopolysaccharides; Male; Neutrophil Activation; Peroxidase; Platelet Activating Factor; Rats; Rats, Wistar; Thiazoles; Thiazolidines; Thrombosis | 2001 |
1-O-alkylglycerols improve boar sperm motility and fertility.
Topics: Animals; Buffers; Cell Survival; Chromatography, High Pressure Liquid; Female; Fertility; Fertilization; Glycerol; In Vitro Techniques; Indicators and Reagents; Insemination, Artificial; Lipid Metabolism; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sperm Motility; Spermatozoa; Stimulation, Chemical; Swine; Thiazoles | 2002 |
E3040 sulphate, a novel thromboxane synthase inhibitor, blocks the Cl- secretion induced by platelet-activating factor in isolated rat colon.
Topics: Animals; Benzothiazoles; Chlorides; Colon; Enzyme Inhibitors; Female; In Vitro Techniques; Intestinal Mucosa; Lipoxygenase Inhibitors; Organic Anion Transporters; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Wistar; Thiazoles; Thromboxane B2; Thromboxane-A Synthase | 2002 |
Mass spectrometric characterization of substituted 2-thiazolin-4-one derivatives.
Topics: Cations; Free Radicals; Platelet Activating Factor; Spectrometry, Mass, Electrospray Ionization; Thiazoles | 2002 |
Effects of tumor necrosis factor alpha antagonist, platelet activating factor antagonist, and nitric oxide synthase inhibitor on experimental otitis media with effusion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Ear, Middle; Enzyme Inhibitors; Etanercept; Immunoglobulin G; Immunohistochemistry; Indoles; Injections, Intralesional; Injections, Intraperitoneal; Lipopolysaccharides; Multivariate Analysis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Otitis Media with Effusion; Photomicrography; Platelet Activating Factor; Pseudomonas aeruginosa; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Thiazoles; Tumor Necrosis Factor-alpha; Tympanic Membrane | 2006 |
Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats.
Topics: Animals; Benzopyrans; Carboxylic Acids; Dermatitis; Dihydropyridines; Imidazoles; Leukotriene B4; Male; Neutrophil Infiltration; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pneumonia; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Leukotriene B4; Skin; Thiazoles | 2008 |
Platelet activating factor induces transient blood-brain barrier opening to facilitate edaravone penetration into the brain.
Topics: Animals; Antipyrine; ATP Binding Cassette Transporter, Subfamily B; Blood-Brain Barrier; Blotting, Western; Brain; Brain Edema; Capillaries; Cerebrospinal Fluid; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Coloring Agents; E-Selectin; Edaravone; Endothelial Cells; Evans Blue; Flow Cytometry; Infusions, Intravenous; Male; Matrix Metalloproteinase 9; Microdialysis; Neuroprotective Agents; Platelet Activating Factor; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Serum Albumin, Radio-Iodinated; Tetrazolium Salts; Thiazoles | 2014 |