Page last updated: 2024-09-02

1-hexadecyl-2-acetyl-glycero-3-phosphocholine and rolipram

1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with rolipram in 17 studies

Compound Research Comparison

Studies
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Trials
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Recent Studies (post-2010)
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Studies
(rolipram)
Trials
(rolipram)
Recent Studies (post-2010) (rolipram)
9,1561875521,60417401

Protein Interaction Comparison

ProteinTaxonomy1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50)rolipram (IC50)
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)1.2233
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)1.2233
Retina-specific copper amine oxidaseHomo sapiens (human)0.0003
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)1.0975
3',5'-cyclic-AMP phosphodiesterase Sus scrofa (pig)3.63
ReninHomo sapiens (human)3.5
Tumor necrosis factorHomo sapiens (human)0.35
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Rattus norvegicus (Norway rat)0.7287
cAMP-specific 3',5'-cyclic phosphodiesterase 4CRattus norvegicus (Norway rat)0.7287
cAMP-specific 3',5'-cyclic phosphodiesterase 4BRattus norvegicus (Norway rat)0.8447
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)1.1942
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.095
Delta-type opioid receptorMus musculus (house mouse)1.5
Delta-type opioid receptorRattus norvegicus (Norway rat)1.5
cAMP-specific 3',5'-cyclic phosphodiesterase 4ARattus norvegicus (Norway rat)0.7287
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)0.835
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)1.1005
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)1.61
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)1.0794
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)0.835
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)2
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AHomo sapiens (human)0.835
cAMP-specific 3',5'-cyclic phosphodiesterase 7BHomo sapiens (human)0.835
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)0.835

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (64.71)18.2507
2000's5 (29.41)29.6817
2010's1 (5.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carmody, LC; Dandapani, S; Donckele, E; Feng, Y; Fernandez, C; Germain, AR; Gupta, PB; Lander, ES; Morgan, B; Munoz, B; Nag, PP; Palmer, M; Perez, JR; Schreiber, SL; Verplank, L1
Cortijo, J; Morcillo, EJ; Ortiz, JL; Vallés, JM1
Fletcher, JR; Noel, PE; Thompson, WJ1
Turner, NC; Wood, LJ1
Battram, CH; Jordan, R; Lewis, SA; Raeburn, D; Sharma, S; Souness, JE; Tomkinson, A; Underwood, SL; Webber, SE; Woodman, VR1
Bou, J; Cortijo, J; Morcillo, EJ; Ortiz, JL; Vallés, JM1
Cortijo, J; Martí-Cabrera, M; Morcillo, EJ; Ortiz, JL; Vallés, JM1
Church, MK; Hatzelmann, A; Schudt, C; Shute, JK; Tenor, H1
Alves, AC; Cordeiro, RS; Cruz, HN; Diaz, BL; Lagente, V; Martins, MA; Pires, AL; Serra, MF1
Berends, C; de Monchy, JG; Dijkhuizen, B; Dubois, AE; Gerritsen, J; Kauffman, HF1
Akuta, K; Manabe, H; Ohmori, K; Okamura, K1
Wise, H1
Dent, G; Djukanović, R; Hidi, R; Holgate, ST; Liu, E; Schudt, C; Timmermans, S1
Akuta, K; Kawasaki, H; Manabe, H; Ohmori, K1
Anderson, R; Steel, HC1
Anam, EM; Blázquez, MA; Cerdá-Nicolás, M; Cortijo, J; Estellés, R; Issekutz, AC; Ivorra, MD; López-Martín, J; Martínez-Losa, M; Milian, L; Morcillo, EJ; O'Connor, JE; Sanz, MJ1
Adamson, RH; Altangerel, A; Curry, FE; Drenckhahn, D; Lenz, JF; Ly, JC; Sarai, RK1

Other Studies

17 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and rolipram

ArticleYear
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
    Bioorganic & medicinal chemistry letters, 2013, Mar-15, Volume: 23, Issue:6

    Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship

2013
Rolipram inhibits PAF-induced airway microvascular leakage in guinea-pig: a comparison with milrinone and theophylline.
    Fundamental & clinical pharmacology, 1992, Volume: 6, Issue:6

    Topics: Animals; Capillary Permeability; Evans Blue; Guinea Pigs; Milrinone; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyridones; Pyrrolidinones; Respiratory System; Rolipram; Theophylline

1992
Rolipram and isoproterenol reverse platelet activating factor-induced increases in pulmonary microvascular permeability and vascular resistance.
    The Journal of surgical research, 1995, Volume: 59, Issue:1

    Topics: Animals; Capillary Permeability; Cyclic AMP; In Vitro Techniques; Isoproterenol; Lung; Male; Phosphodiesterase Inhibitors; Platelet Activating Factor; Protein Kinase C; Pyrrolidinones; Rats; Rolipram; Vascular Resistance

1995
Superoxide generation by guinea-pig peritoneal macrophages is inhibited by rolipram, staurosporine and mepacrine in an agonist-dependent manner.
    Cellular signalling, 1994, Volume: 6, Issue:8

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Macrophages, Peritoneal; Male; N-Formylmethionine Leucyl-Phenylalanine; Phospholipases A; Phospholipases A2; Phosphoric Diester Hydrolases; Platelet Activating Factor; Protein Kinase C; Pyrrolidinones; Quinacrine; Respiratory Burst; Rolipram; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan

1994
Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor.
    British journal of pharmacology, 1994, Volume: 113, Issue:4

    Topics: Albuterol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Bronchial Hyperreactivity; Bronchial Spasm; Bronchodilator Agents; Capillary Permeability; Guinea Pigs; Hemodynamics; Histamine; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyridines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram

1994
Rolipram inhibits airway microvascular leakage induced by platelet-activating factor, histamine and bradykinin in guinea-pigs.
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:12

    Topics: Aminophylline; Animals; Blood Pressure; Bradykinin; Bronchi; Capillary Permeability; Drug Interactions; Evans Blue; Guinea Pigs; Histamine; Microcirculation; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyrrolidinones; Rolipram; Trachea

1993
Effects of selective phosphodiesterase inhibitors on platelet-activating factor- and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs.
    Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 353, Issue:2

    Topics: Animals; Asthma; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Histamine; Male; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyrrolidinones; Respiratory System; Rolipram

1996
Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects.
    British journal of pharmacology, 1996, Volume: 118, Issue:7

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Bronchodilator Agents; Chemotaxis, Leukocyte; Complement C5a; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Activation; Eosinophils; Humans; Hypersensitivity, Immediate; In Vitro Techniques; Leukotriene C4; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyrrolidinones; Rolipram; Theophylline

1996
Selective inhibition of phosphodiesterase type IV suppresses the chemotactic responsiveness of rat eosinophils in vitro.
    European journal of pharmacology, 1996, Sep-19, Volume: 312, Issue:1

    Topics: Adrenergic beta-Agonists; Animals; Bucladesine; Chemotaxis, Leukocyte; Colforsin; Cyclic AMP; Eosinophils; Isoenzymes; Leukotriene B4; Phosphodiesterase Inhibitors; Platelet Activating Factor; Platelet Aggregation; Pyrrolidinones; Rats; Rats, Wistar; Rolipram

1996
Inhibition of PAF-induced expression of CD11b and shedding of L-selectin on human neutrophils and eosinophils by the type IV selective PDE inhibitor, rolipram.
    The European respiratory journal, 1997, Volume: 10, Issue:5

    Topics: Bucladesine; CD11 Antigens; Dinoprostone; Eosinophils; Flow Cytometry; Humans; Isoproterenol; L-Selectin; Neutrophils; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyrrolidinones; Rolipram

1997
KF19514, a phosphodieterase 4 and 1 inhibitor, inhibits PAF-induced lung inflammatory responses by inhaled administration in guinea pigs.
    International archives of allergy and immunology, 1997, Volume: 114, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Acetylcholine; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Electric Stimulation; Eosinophils; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Naphthyridines; Neurokinin A; Neutrophils; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Activating Factor; Pyrrolidinones; Respiratory Therapy; Rolipram; Substance P

1997
Activation of the prostaglandin EP4-receptor subtype is highly coupled to inhibition of N-formyl-methionyl-leucyl-phenylalanine-stimulated rat neutrophil aggregation.
    Prostaglandins, leukotrienes, and essential fatty acids, 1998, Volume: 58, Issue:1

    Topics: Animals; Biphenyl Compounds; Cell Aggregation; Cyclic AMP; Dinoprostone; Epoprostenol; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Rolipram

1998
Phosphodiesterase and cyclic adenosine monophosphate-dependent inhibition of T-lymphocyte chemotaxis.
    The European respiratory journal, 2000, Volume: 15, Issue:2

    Topics: Albuterol; Asthma; Bucladesine; Chemotaxis, Leukocyte; Colforsin; Cyclic AMP; Humans; Interleukin-8; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Activating Factor; Rolipram; T-Lymphocytes; Theophylline

2000
The inhaled administration of KF19514, a phosphodiesterase 4 and 1 inhibitor, prevents antigen-induced lung inflammation in guinea pigs.
    Pulmonary pharmacology & therapeutics, 2000, Volume: 13, Issue:1

    Topics: Acetylcholine; Administration, Inhalation; Airway Resistance; Aminophylline; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Disease Models, Animal; Eosinophils; Guinea Pigs; Male; Naphthyridines; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pneumonia; Rolipram; Specific Pathogen-Free Organisms; Vasodilator Agents

2000
Dissociation of the PAF-receptor from NADPH oxidase and adenylate cyclase in human neutrophils results in accelerated influx and delayed clearance of cytosolic calcium.
    British journal of pharmacology, 2002, Volume: 136, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenylyl Cyclases; Bucladesine; Calcium; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytosol; Homeostasis; Humans; In Vitro Techniques; Leukocyte Elastase; Luminescent Measurements; Membrane Potentials; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; Phenethylamines; Phosphodiesterase Inhibitors; Platelet Activating Factor; Platelet Membrane Glycoproteins; Purinergic P1 Receptor Agonists; Radioimmunoassay; Receptor, Adenosine A2A; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Rolipram; Spectrometry, Fluorescence; Superoxides

2002
Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte-endothelial cell interactions in vivo.
    British journal of pharmacology, 2003, Volume: 140, Issue:6

    Topics: Adenosine Monophosphate; Alkaloids; Animals; Calcium; Cell Communication; Cell Line; Colforsin; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Leukocyte Rolling; Leukocytes; Male; Microscopy, Video; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenanthrenes; Plant Extracts; Platelet Activating Factor; Protein Binding; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rolipram

2003
Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:3

    Topics: Adrenergic beta-Agonists; Animals; Cadherins; Capillary Permeability; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Indicators and Reagents; Isoproterenol; Male; Microscopy, Confocal; Phosphodiesterase Inhibitors; Platelet Activating Factor; rap1 GTP-Binding Proteins; Rats; Rats, Sprague-Dawley; Rolipram; Signal Transduction; Splanchnic Circulation

2008