Page last updated: 2024-09-02

1-hexadecyl-2-acetyl-glycero-3-phosphocholine and ro 31-8220

1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with ro 31-8220 in 9 studies

Compound Research Comparison

Studies
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Trials
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Recent Studies (post-2010)
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Studies
(ro 31-8220)
Trials
(ro 31-8220)
Recent Studies (post-2010) (ro 31-8220)
9,156187552587164

Protein Interaction Comparison

ProteinTaxonomy1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50)ro 31-8220 (IC50)
Ribosomal protein S6 kinase alpha-5Homo sapiens (human)0.008
Serine/threonine-protein kinase 10Homo sapiens (human)0.099
cAMP-dependent protein kinase catalytic subunit alphaBos taurus (cattle)0.9
Serine/threonine-protein kinase pim-1Homo sapiens (human)0.01
Protein kinase C alpha typeHomo sapiens (human)0.033
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)0.0068
Ribosomal protein S6 kinase beta-1Homo sapiens (human)0.015
Mitogen-activated protein kinase kinase kinase 8Homo sapiens (human)9.95
Glycogen synthase kinase-3 betaHomo sapiens (human)0.0116
Ribosomal protein S6 kinase alpha-3Homo sapiens (human)0.01
Protein kinase C beta typeRattus norvegicus (Norway rat)0.01
Homeodomain-interacting protein kinase 1Homo sapiens (human)0.621
NAD-dependent protein deacetylase sirtuin-2Homo sapiens (human)0.875
Mitogen-activated protein kinase kinase kinase kinase 1Homo sapiens (human)0.0529
NAD-dependent protein deacetylase sirtuin-1Homo sapiens (human)3.9
Serine/threonine-protein kinase VRK1Homo sapiens (human)0.743
NAD-dependent protein deacetylase sirtuin-3, mitochondrialHomo sapiens (human)3.7
Serine/threonine-protein kinase TBK1Homo sapiens (human)0.656

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (66.67)18.2507
2000's3 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Joseph, S; MacDermot, J1
Murphy, CT; Westwick, J1
Northover, AM; Northover, BJ2
Alverez, J; Garcia-Sancho, J; Montero, M1
Giembycz, MA; Hellewell, PG; Lindsay, MA; Teixeira, MM1
Ahmed, A; Ahmed, Z; Dearn, S; Eggo, MC; Lewis, A; Rahman, M1
Chang, PY; Chen, CH; Henry, PD; Jiang, T; Lee, YT; Lu, SC; Luo, S1
Bazan, NG; Bernatchez, PN; GĂ©linas, DS; Rollin, S; Sirois, MG1

Other Studies

9 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and ro 31-8220

ArticleYear
Thrombin promotes actin polymerization in U937 human monocyte-macrophage cells. Analysis of the signalling mechanisms mediating actin polymerization.
    The Biochemical journal, 1992, Sep-15, Volume: 286 ( Pt 3)

    Topics: Actins; Alkaloids; Calcium; Cations, Divalent; Cell Line; Chemotaxis, Leukocyte; GTP-Binding Proteins; Humans; Indoles; Ionomycin; Macrophages; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Polymers; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Virulence Factors, Bordetella

1992
Selective inhibition of protein kinase C. Effect on platelet-activating-factor-induced platelet functional responses.
    The Biochemical journal, 1992, Apr-01, Volume: 283 ( Pt 1)

    Topics: Animals; Blood Platelets; Calcium; Enzyme Activation; Indoles; Kinetics; Maleimides; Phosphorylation; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Rabbits; Serotonin; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboxane B2

1992
Lectin-induced increase in microvascular permeability to colloidal carbon in vitro may involve protein kinase C activation.
    Agents and actions, 1994, Volume: 41, Issue:3-4

    Topics: Animals; Calcimycin; Capillary Permeability; Carbon; Concanavalin A; Enzyme Activation; In Vitro Techniques; Indoles; Intestine, Small; Lectins; Peanut Agglutinin; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Protein Kinase C; Rats; Serotonin; Wheat Germ Agglutinins

1994
Chemotactic peptide down-regulation of calcium mobilization induced by platelet-activating factor and by leukotriene B4 in human neutrophils is uncovered by protein phosphatase inhibitors.
    The Biochemical journal, 1994, Oct-15, Volume: 303 ( Pt 2)

    Topics: Alkaloids; Calcium; Down-Regulation; Ethers, Cyclic; Humans; Indoles; Leukotriene B4; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Signal Transduction; Staurosporine

1994
Involvement of protein kinase C in the control of microvascular permeability to colloidal carbon.
    Agents and actions, 1993, Volume: 39, Issue:3-4

    Topics: Animals; Capillary Permeability; Carbon; Colloids; Cyclooxygenase Inhibitors; In Vitro Techniques; Indoles; Indomethacin; Intestinal Absorption; Platelet Activating Factor; Protein Kinase C; Rats; Serotonin; Serotonin Antagonists

1993
Pertussis toxin shows distinct early signalling events in platelet-activating factor-, leukotriene B4-, and C5a-induced eosinophil homotypic aggregation in vitro and recruitment in vivo.
    Blood, 1997, Jun-15, Volume: 89, Issue:12

    Topics: Animals; Calcium; Cell Aggregation; Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5a; Enzyme Inhibitors; Eosinophils; Female; GTP-Binding Proteins; Guinea Pigs; Indoles; Isoenzymes; Isoquinolines; Leukotriene B4; Pertussis Toxin; Phospholipase C beta; Platelet Activating Factor; Protein Kinase C; Signal Transduction; Staurosporine; Sulfonamides; Type C Phospholipases; Virulence Factors, Bordetella

1997
Activation of platelet-activating factor (PAF) receptor stimulates nitric oxide (NO) release via protein kinase C-alpha in HEC-1B human endometrial epithelial cell line.
    Molecular medicine (Cambridge, Mass.), 2000, Volume: 6, Issue:1

    Topics: Azepines; Calcium; Cell Line; Endometrium; Enzyme Activation; Epithelial Cells; Female; Humans; Indoles; Infertility, Female; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Kinase C-alpha; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles

2000
Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids.
    Circulation, 2001, Jul-31, Volume: 104, Issue:5

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Azepines; Blotting, Northern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Egtazic Acid; Endothelium, Vascular; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; GTP-Binding Proteins; Indoles; Isoquinolines; Lipoproteins, LDL; Pertussis Toxin; Phospholipases A; Platelet Activating Factor; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Signal Transduction; Sulfonamides; Triazoles; Virulence Factors, Bordetella

2001
Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways.
    British journal of pharmacology, 2002, Volume: 137, Issue:7

    Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Animals; Calcimycin; Calcium; Cattle; Cells, Cultured; Chelating Agents; Chromones; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Egtazic Acid; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Ginkgolides; Indoles; Intercellular Signaling Peptides and Proteins; Ionophores; Lactones; Lymphokines; Maleimides; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serine; Signal Transduction; Time Factors; Type C Phospholipases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin

2002