1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with piperidines in 52 studies
| Studies (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Trials (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Recent Studies (post-2010) (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Studies (piperidines) | Trials (piperidines) | Recent Studies (post-2010) (piperidines) |
|---|---|---|---|---|---|
| 9,156 | 187 | 552 | 40,235 | 5,221 | 14,545 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.92) | 18.7374 |
| 1990's | 35 (67.31) | 18.2507 |
| 2000's | 15 (28.85) | 29.6817 |
| 2010's | 1 (1.92) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Almansa, C; Bartrolí, J; Carceller, E; Forn, J; García-Rafanell, J; Giral, M; Merlos, M | 1 |
| Berdel, WE; Danhauser-Riedl, S; Houlihan, WJ; Koenigsmann, M; Reufi, B; Thiel, E; Zafferani, M | 1 |
| Affrime, MB; Billah, MM; Brannan, MD; Christopher, JD; Eckel, SP; Gilchrest, HG; Granzow, CA; Lawton, PJ; Radwanski, E; Richards, W | 1 |
| Cardillo, R; DiMuzio, J; Post, TJ; Raible, DG; Schulman, ES | 1 |
| Braquet, C; Köpernik, W; Mest, HJ; Rein, T; Riedel, A | 1 |
| Asano, O; Harada, K; Katayama, K; Kimura, A; Kobayashi, S; Murakami, M; Nagaoka, J; Yamada, K; Yamatsu, I; Yoshimura, T | 1 |
| Billah, MM; Ganguly, AK; Green, MJ; Kreutner, W; Piwinski, JJ; West, RE; Wong, JK | 1 |
| Billah, MM; Chapman, RW; Egan, RW; Kreutner, W; Siegel, MI; Watnick, AS | 1 |
| Billah, MM; Egan, RW; Ganguly, AK; Green, MJ; Kreutner, W; Piwinski, JJ; Siegel, MI; Villani, FJ; Wong, JK | 1 |
| Braquet, P; Esanu, A; Hosford, D; Laurent, JP; Martin, C; Pommier, J; Rolland, A | 1 |
| Berdel, WE; Busch, R; Danhauser-Riedl, S; Felix, SB; Houlihan, WJ; Kalvelage, H; Oberberg, D; Rastetter, J; Steinhauser, G; Zafferani, M | 1 |
| Benavides, J; Gotti, B; MacKenzie, ET; Scatton, B | 1 |
| Billah, MM; Chapman, RW; Egan, RW; Gilchrest, H; Kreutner, W; Piwinski, JJ; Sherwood, J; Siegel, MI; West, RE | 1 |
| Hechtman, HB; Shepro, D; Valeri, CR | 1 |
| Kamei, C; Nakamura, S; Tasaka, K | 1 |
| Bertrand, C; Desai, MC; Geppetti, P; Nadel, JA; Piedimonte, G; Snider, RM | 1 |
| Bel-Haouari, M; Boudjema, K; Chenard, MP; Cinqualbre, J; Doghmi, M; Jaeck, D; Takada, Y; Wolf, P | 1 |
| Handley, DA; Houlihan, WJ; Jaeggi, CS; Lee, ML; Munder, PG; Nemecek, GA; Winslow, CW | 1 |
| Boudjema, K; Chenard, MP; Cinqualbre, J; Jaeck, D; Takada, Y; Wolf, P; Yamaoka, Y | 1 |
| Howell, RE; Kovalsky, MP; Laemont, KD | 1 |
| Abe, T; Matsuda, K; Nagai, H; Omata, T; Segawa, Y; Yoshida, K | 1 |
| Almansa, C; Balsa, D; Bartrolí, J; Carceller, E; Forn, J; García-Rafanell, J; Giral, M; Merlos, M | 1 |
| Asano, O; Horie, T; Suzuki, H; Tadano, K | 1 |
| Kambayashi, J; Kawasaki, T; Mori, T; Ou, MC; Sakon, M; Shiba, E; Shinozaki, K; Uemura, Y; Yukawa, M | 1 |
| Mochizuki, H; Ono, S; Tamakuma, S | 1 |
| Heptinstall, S; Lösche, W; Sanderson, HM; Vickers, J | 1 |
| Ando, H; Kobayashi, K; Nakatani, T; Sakamoto, Y | 1 |
| Akiyama, K; Maeda, Y; Mita, H; Saito, H; Shimizu, H | 1 |
| Kishimoto, S; Kodaka, T; Kondo, S; Nakane, S; Sugiura, T; Tonegawa, T; Waku, K; Yamashita, A | 1 |
| Berger, MR; Brun, R; Kaminsky, R; Konstantinov, SM; Zillmann, U | 1 |
| Fukao, K; Fukunaga, K; Iijima, T; Otsuka, M; Takada, Y; Taniguchi, H; Todoroki, T; Yuzawa, K | 1 |
| Inagaki, N; Koda, A; Nagai, H; Ueno, M | 1 |
| Fukao, K; Fukunaga, K; Otsuka, M; Takada, Y; Taniguchi, H; Yuzawa, K | 1 |
| Fukao, K; Fukunaga, K; Goto, K; Otsuka, M; Takada, Y; Taniguchi, H | 1 |
| Chambers, EL; Downing, SJ; Leese, HJ; Maguiness, SD; Watson, A | 1 |
| Billah, MM; Carruthers, NI; Chan, TM; Kaminski, JJ; McPhail, AT; Tozzi, S; Wong, SC | 1 |
| Fukao, K; Fukunaga, K; Gu, M; Ishiguro, S; Otsuka, M; Seino, K; Takada, Y; Taniguchi, H; Yuzawa, K | 1 |
| Asai, Y; Iwamoto, K; Murahashi, N; Nomura, T | 1 |
| Asai, Y; Watanabe, S | 1 |
| Degawa, H; Hama, K; Iwamoto, H; Kikuchi, K; Kozaki, K; Kozaki, M; Matsuno, N; Nagao, T; Narumi, Y; Takeuchi, H; Uchiyama, M | 1 |
| Fukao, K; Fukunaga, K; Gu, M; Ishiguro, S; Otsuka, M; Seino, K; Takada, Y; Taniguchi, H; Todoroki, T; Yuzawa, K | 1 |
| Endo, S; Hirashima, Y; Kobayashi, N; Nukui, H; Takaku, A | 1 |
| Brugnara, C; Jarolim, P; Rivera, A | 1 |
| Ichinowatari, G; Ohuchi, K; Tanimoto, A; Tsuyuki, K; Yaginuma, H; Yamada, M | 1 |
| Ashton, D; Fransen, JF; Hens, KA; Heylen, L; Hillen, LC; Janssens, F; Jurzak, MR; Leysen, JE; Mahieu, M; Megens, AA; Vermeire, JC; Vermote, PC | 1 |
| Abe, Y; Hori, T; Kasuya, H; Suzuki, S; Yamanishi, Y | 1 |
| Amemiya, T; Fujimura, M; Ishiura, Y; Kurashima, K; Myou, S; Nobata, K; Nonomura, A | 1 |
| D'Amico, M; Di Filippo, C; Getting, SJ; Lam, CW; Rossi, F | 1 |
| Aarons, L; Brearley, C; Evans, L | 1 |
| Asai, Y | 1 |
| Cloutier, S; Richter, M; Sirois, P | 1 |
| Atsumi, I; Fujii, A; Iemura, M; Kida, T; Sakai, O; Sakaki, H; Wada, T | 1 |
2 review(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and piperidines
| Article | Year |
|---|---|
From ginkgolides to N-substituted piperidino-thieno diazepines, a new series of highly potent dual antagonists.
Topics: Animals; Azepines; Diterpenes; Ginkgolides; Humans; Lactones; Piperidines; Plant Extracts; Platelet Activating Factor; Tetrazoles; Thienopyridines; Triazoles | 1991 |
Role of humoral mediators in adult respiratory distress syndrome.
Topics: Animals; Arachidonic Acids; Chemotaxis, Leukocyte; Chromones; Dogs; Guinea Pigs; Humans; Hypertension, Pulmonary; Inflammation; Ketanserin; Leukocyte Count; Leukocytes; Lung; Piperidines; Platelet Activating Factor; Pulmonary Embolism; Respiratory Distress Syndrome; Serotonin; Serotonin Antagonists; SRS-A; Thromboxane A2 | 1984 |
4 trial(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and piperidines
| Article | Year |
|---|---|
Differential plasma duration of antiplatelet-activating factor and antihistamine activities of oral Sch 37370 in humans.
Topics: Administration, Oral; Adult; Double-Blind Method; Electrocardiography; Histamine Antagonists; Humans; Loratadine; Male; Piperidines; Platelet Activating Factor | 1992 |
A clinical study on the significance of platelet-activating factor in the pathophysiology of septic disseminated intravascular coagulation in surgery.
Topics: Carcinoma, Hepatocellular; Data Interpretation, Statistical; Disseminated Intravascular Coagulation; Endotoxins; Gastrointestinal Neoplasms; Humans; Liver Neoplasms; Piperidines; Platelet Activating Factor; Pyridinium Compounds; Sepsis; Surgical Procedures, Operative | 1996 |
Effect of a platelet-activating factor receptor antagonist, E5880, on cerebral vasospasm after aneurysmal subarachnoid hemorrhage--open clinical trial to investigate efficacy and safety.
Topics: Adult; Aged; Aneurysm, Ruptured; Brain; Clinical Protocols; Dose-Response Relationship, Drug; Female; Humans; Incidence; Injections, Intravenous; Intracranial Aneurysm; Male; Middle Aged; Piperidines; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridinium Compounds; Radiography; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Subarachnoid Hemorrhage; Treatment Outcome; Vasospasm, Intracranial | 2001 |
A pharmacokinetic/pharmacodynamic model for a platelet activating factor antagonist based on data arising from Phase I studies.
Topics: Administration, Oral; Dose-Response Relationship, Drug; Double-Blind Method; Forecasting; Histamine; Humans; Imidazoles; Injections, Intradermal; Male; Models, Biological; Piperidines; Platelet Activating Factor; Platelet Aggregation; Single-Blind Method; Skin Tests; Time Factors; United Kingdom | 2005 |
46 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and piperidines
| Article | Year |
|---|---|
(Pyridylcyanomethyl)piperazines as orally active PAF antagonists.
Topics: Administration, Oral; Animals; Biological Availability; Blood Pressure; In Vitro Techniques; Male; Mice; Piperazines; Piperidines; Platelet Activating Factor; Platelet Aggregation; Rabbits; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1992 |
Lack of therapeutic effects of platelet activating factor antagonists in WEHI-3B leukemia, human xenotransplanted colorectal and lung cancer and Lewis-lung tumor in vivo.
Topics: Animals; Antineoplastic Agents; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Female; Humans; Imidazoles; Isoquinolines; Leukemia, Experimental; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Neoplasm Transplantation; Piperidines; Platelet Activating Factor | 1992 |
Mast cell mediators prostaglandin-D2 and histamine activate human eosinophils.
Topics: Azepines; Calcimycin; Calcium; Cytosol; Dinoprostone; Eosinophils; Histamine; Histamine Antagonists; Humans; In Vitro Techniques; Lung; Mast Cells; Neutrophils; Piperidines; Platelet Activating Factor; Prostaglandin D2; Secretory Rate; SRS-A; Triazoles | 1992 |
Effect of BN 52256 and other mediator antagonists on ouabain-induced ventricular fibrillation in sensitized guinea-pigs and on ischemia-induced fibrillation in rats.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Azepines; Clemastine; Coronary Disease; Coronary Vessels; Guinea Pigs; Organoselenium Compounds; Ouabain; Piperidines; Platelet Activating Factor; Propranolol; Rats; Triazoles; Umbelliferones; Ventricular Fibrillation | 1992 |
Inhibitory effects of the novel platelet activating factor receptor antagonist, 1-ethyl-2-[N-(2-methoxy)benzoyl-N-[(2R)-2-methoxy-3-(4- octadecylcarbamoyloxy) piperidinocarbonyloxypropyloxy]carbonyl] aminomethyl-pyridinium chloride, in several experimenta
Topics: Animals; Gas Chromatography-Mass Spectrometry; Hypotension; Lipopolysaccharides; Mice; Mice, Inbred ICR; Passive Cutaneous Anaphylaxis; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridinium Compounds; Rats; Rats, Inbred F344; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock | 1991 |
Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines.
Topics: Animals; Guinea Pigs; Histamine H1 Antagonists; Indicators and Reagents; Lung; Molecular Structure; Piperidines; Platelet Activating Factor; Receptors, Histamine H1; Structure-Activity Relationship | 1991 |
Sch 37370: a new drug combining antagonism of platelet-activating factor (PAF) with antagonism of histamine.
Topics: Animals; Antigens; Bronchial Spasm; Guinea Pigs; Histamine Antagonists; Humans; Hyperventilation; Loratadine; Male; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Lew | 1991 |
Discovery and preliminary pharmacology of Sch 37370, a dual antagonist of PAF and histamine.
Topics: Histamine Antagonists; Humans; Kinetics; Loratadine; Male; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Structure-Activity Relationship | 1991 |
Some antagonists of platelet activating factor are cytotoxic for human malignant cell lines.
Topics: Antineoplastic Agents; Cell Survival; Humans; Imidazoles; Isoquinolines; Piperidines; Platelet Activating Factor; Platelet Aggregation; Tumor Cells, Cultured | 1991 |
The pharmacotherapy of focal cortical ischaemia in the mouse.
Topics: Animals; Calcium Channel Blockers; Cell Survival; Cyclandelate; Ischemic Attack, Transient; Male; Mice; Molecular Structure; N-Methylaspartate; Piperidines; Platelet Activating Factor; Receptors, GABA-A; Receptors, Opioid; Receptors, sigma; Vincamine | 1990 |
Sch 37370: a potent, orally active, dual antagonist of platelet-activating factor and histamine.
Topics: Administration, Oral; Animals; Binding, Competitive; Brain; Bronchial Spasm; Female; Guinea Pigs; Histamine; Histamine Antagonists; Humans; Loratadine; Lung; Macaca fascicularis; Male; Mice; Piperidines; Platelet Activating Factor; Platelet Aggregation; Pyrilamine; Rats | 1990 |
Effects of antiallergic agents including levocabastine on experimental rhinitis in rats.
Topics: Acetylcholine; Animals; Antigens, Helminth; Ascaris; Histamine; Histamine H1 Antagonists; Ketotifen; Male; Nasal Mucosa; Piperidines; Platelet Activating Factor; Rats; Rats, Wistar; Rhinitis; Substance P | 1994 |
A new NK1 receptor antagonist (CP-99,994) prevents the increase in tracheal vascular permeability produced by hypertonic saline.
Topics: Animals; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Edema; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Hypertonic Solutions; Neurokinin A; Neurons, Afferent; Piperidines; Platelet Activating Factor; Rats; Rats, Inbred F344; Receptors, Neurotransmitter; Receptors, Tachykinin; Sodium Chloride; Stimulation, Chemical; Substance P; Trachea; Tracheal Diseases | 1993 |
Effects of platelet-activating factor antagonist on preservation/reperfusion injury of the graft in porcine orthotopic liver transplantation.
Topics: Adenosine; Allopurinol; Animals; Glutathione; Graft Rejection; Insulin; Leukocyte Count; Liver; Liver Transplantation; Microscopy, Electron; Mitochondria, Liver; Organ Preservation Solutions; Piperidines; Platelet Activating Factor; Pyridinium Compounds; Raffinose; Reperfusion Injury; Swine; Tissue Preservation; Transaminases | 1995 |
Antitumor activity of a piperidine phospholipid.
Topics: Animals; Antineoplastic Agents; Binding, Competitive; Cell Survival; Fibroblasts; Fibrosarcoma; Humans; Lethal Dose 50; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Phospholipid Ethers; Piperidines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Platelet-Derived Growth Factor; Sarcoma, Experimental; Tumor Cells, Cultured | 1994 |
Platelet activating factor antagonist has a protective effect on preservation/reperfusion injury of the graft in pig liver transplantation.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Heparin; Hepatectomy; Ketone Bodies; Lactates; Leukocyte Count; Liver Transplantation; Neutrophils; Organ Preservation; Piperidines; Platelet Activating Factor; Platelet Count; Pyridinium Compounds; Random Allocation; Reperfusion Injury; Swine; Time Factors | 1995 |
Methoctramine induces nonspecific airway hyperresponsiveness in vivo.
Topics: Aerosols; Albuterol; Animals; Arachidonic Acid; Atropine; Bronchial Hyperreactivity; Bronchoconstriction; Diamines; Drug Synergism; Gallamine Triethiodide; Guinea Pigs; Histamine; Male; Muscarinic Antagonists; Ovalbumin; Parasympatholytics; Piperazines; Piperidines; Platelet Activating Factor; Propranolol; Receptors, Muscarinic | 1994 |
Effects of ZCR-2060 on allergic airway inflammation and cell activation in guinea-pigs.
Topics: Animals; Benzoates; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Eosinophils; Guinea Pigs; Inflammation; Leukotriene B4; Macrophages, Alveolar; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperidines; Platelet Activating Factor; Respiratory Hypersensitivity; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
[(3-Pyridylalkyl)piperidylidene]benzocycloheptapyridine derivatives as dual antagonists of PAF and histamine.
Topics: Anaphylaxis; Animals; Benzocycloheptenes; Blood Pressure; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Structure; Muscle Contraction; Muscle, Smooth; Piperidines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1994 |
Radioimmunoassay for the novel platelet activating factor receptor antagonist E5880.
Topics: Adsorption; Animals; Chromatography, High Pressure Liquid; Dogs; Drug Stability; Immune Sera; Male; Piperidines; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridinium Compounds; Rabbits; Radioimmunoassay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sensitivity and Specificity; Solutions; Spectrophotometry, Ultraviolet; Water | 1994 |
Potential etiologic role of PAF in two major septic complications; disseminated intravascular coagulation and multiple organ failure.
Topics: Alanine Transaminase; Animals; Bacterial Infections; Blood Cell Count; Blood Urea Nitrogen; Cholangitis; Common Bile Duct; Disseminated Intravascular Coagulation; Endotoxins; Fibrinogen; Hematocrit; Liver; Male; Multiple Organ Failure; Partial Thromboplastin Time; Piperidines; Platelet Activating Factor; Pyridinium Compounds; Rabbits | 1994 |
Studies on the effects of agonists and antagonists on platelet shape change and platelet aggregation in whole blood.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Azepines; Blood Platelets; Humans; In Vitro Techniques; Piperazines; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Serotonin; Succinates; Sulfonamides; Thromboxane A2; Triazoles; Vasoconstrictor Agents | 1996 |
Effects of platelet-activating factor antagonist E5880 on intrahepatic and systemic metabolic responses to transient hepatic inflow occlusion and reperfusion in the rabbit.
Topics: 6-Ketoprostaglandin F1 alpha; Adenine Nucleotides; Ammonia; Analysis of Variance; Animals; Blood Gas Analysis; Blood Glucose; Energy Metabolism; Hydrogen-Ion Concentration; Lactic Acid; Liver; Male; Piperidines; Platelet Activating Factor; Pyridinium Compounds; Pyruvic Acid; Rabbits; Reperfusion Injury; Thromboxane B2 | 1996 |
Histamine augments VCAM-1 expression on IL-4- and TNF-alpha-stimulated human umbilical vein endothelial cells.
Topics: Amanitins; Antibodies, Blocking; Antigens, CD; Cell Adhesion; Cells, Cultured; Cimetidine; Eosinophils; Histamine; Histamine Antagonists; Humans; Immunohistochemistry; Integrin alpha4; Interleukin-4; Piperidines; Platelet Activating Factor; Pyrilamine; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 1996 |
2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: Arachidonic Acids; Benzoxazines; Calcium; Cannabinoids; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Glioma; Glycerides; Hybrid Cells; Ligands; Morpholines; Naphthalenes; Neuroblastoma; Neurons; Piperidines; Platelet Activating Factor; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1996 |
Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Drug Synergism; Drug Therapy, Combination; Female; Mice; Microbial Sensitivity Tests; Molecular Structure; Phenylbutazone; Phosphorylcholine; Piperidines; Platelet Activating Factor; Specific Pathogen-Free Organisms; Trypanosoma brucei brucei; Trypanosomiasis, African | 1997 |
Prolonged hepatic warm ischemia in non-heart-beating donors: protective effects of FK506 and a platelet activating factor antagonist in porcine liver transplantation.
Topics: Adenosine Triphosphate; Animals; Aspartate Aminotransferases; Immunosuppressive Agents; Ischemia; Liver; Liver Transplantation; Piperidines; Platelet Activating Factor; Pyridinium Compounds; Swine; Tacrolimus | 1998 |
Antiallergic action of betotastine besilate (TAU-284) in animal models: A comparison with ketotifen.
Topics: Animals; Anti-Allergic Agents; Asthma; Bronchoconstriction; Disease Models, Animal; Eosinophilia; Eosinophils; Female; Guinea Pigs; Histamine H1 Antagonists; Hypersensitivity; Ketotifen; Male; Passive Cutaneous Anaphylaxis; Piperidines; Platelet Activating Factor; Pyridines; Rats; Rats, Wistar | 1998 |
Energy metabolism of hepatic allografts subjected to prolonged warm ischemia and pharmacologic modulation with FK506 and platelet activating factor antagonist.
Topics: Adenine Nucleotides; Animals; Aspartate Aminotransferases; Energy Metabolism; Graft Survival; Ischemia; Liver; Liver Transplantation; Organ Preservation; Piperidines; Platelet Activating Factor; Postoperative Period; Pyridinium Compounds; Swine; Tacrolimus; Temperature; Transplantation, Homologous | 1998 |
Successful liver transplantation from non-heart-beating donors by blockade of endothelin and PAE.
Topics: Animals; Endothelin Receptor Antagonists; Graft Survival; Heart Arrest, Induced; Liver Transplantation; Peptides, Cyclic; Piperidines; Platelet Activating Factor; Potassium Chloride; Pyridinium Compounds; Swine; Tissue Donors; Transplantation, Homologous | 1998 |
Effect of inflammatory mediators on the electrophysiology of the human oviduct.
Topics: Alprostadil; Calcium; Cells, Cultured; Chlorides; Dinoprostone; Electric Conductivity; Electrophysiology; Epithelial Cells; Fallopian Tubes; Female; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Ion Channels; Leukotriene B4; Membrane Potentials; Piperidines; Platelet Activating Factor | 1999 |
Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine.
Topics: Animals; Anti-Allergic Agents; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Guinea Pigs; Histamine Antagonists; Humans; Inhibitory Concentration 50; Isoquinolines; Loratadine; Mice; Models, Molecular; Molecular Conformation; Molecular Mimicry; Piperazines; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridines; Rats; Receptors, Histamine H1; Stereoisomerism; Structure-Activity Relationship | 1999 |
Improvement of allograft viability with organs procured from non-heart-beating donors in porcine liver transplantation.
Topics: Animals; Endothelin-1; Graft Survival; Heart Arrest; Liver Transplantation; Peptides, Cyclic; Piperidines; Platelet Activating Factor; Pyridinium Compounds; Swine; Tacrolimus; Time Factors; Tissue and Organ Harvesting; Transplantation, Homologous | 2000 |
A temperature study on critical micellization concentration of the novel platelet-activating factor receptor antagonist E5880 in water by electric conductivity measurements.
Topics: Drug Administration Routes; Electricity; Micelles; Physical Phenomena; Physics; Piperidines; Platelet Activating Factor; Pyridinium Compounds; Temperature; Water | 2000 |
Characterization of the physicochemical properties of the micelles by the novel platelet activating factor receptor antagonist E5880.
Topics: Algorithms; Chemical Phenomena; Chemistry, Physical; Light; Micelles; Molecular Weight; Particle Size; Piperidines; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Scattering, Radiation; Spectrometry, Fluorescence; Surface Properties | 2000 |
Beneficial effect of machine perfusion preservation on liver transplantation from non-heart-beating donors.
Topics: Adenosine; Allopurinol; Animals; Aspartate Aminotransferases; Cold Temperature; Endothelin Receptor Antagonists; Glutathione; Graft Survival; Heart Arrest; Hyaluronic Acid; Insulin; L-Lactate Dehydrogenase; Liver; Liver Transplantation; Organ Preservation; Organ Preservation Solutions; Peptides, Cyclic; Perfusion; Piperidines; Platelet Activating Factor; Pyridinium Compounds; Raffinose; Swine; Transplantation, Homologous | 2000 |
Role of platelet-activating factor in hepatectomy with Pringle's maneuver.
Topics: Adenine Nucleotides; Animals; Blood Pressure; Endothelin-1; Energy Metabolism; Enzymes; Female; Hemostatic Techniques; Hepatectomy; Leukocytes; Liver; Piperidines; Platelet Activating Factor; Portal Vein; Postoperative Period; Pyridinium Compounds; Rabbits; Survival Analysis | 2001 |
Modulation of Gardos channel activity by cytokines in sickle erythrocytes.
Topics: Anemia, Sickle Cell; Calcium; Cell Size; Chemokine CCL5; Cytokines; Endothelin Receptor Antagonists; Endothelin-1; Erythrocyte Count; Erythrocytes, Abnormal; Humans; Interleukin-10; Kinetics; Oligopeptides; Piperidines; Platelet Activating Factor; Platelet Membrane Glycoproteins; Potassium Channels, Calcium-Activated; Protein Kinase C; Receptor, Endothelin B; Receptors, CCR5; Receptors, Cell Surface; Receptors, Chemokine; Receptors, Endothelin; Receptors, G-Protein-Coupled; Rubidium Radioisotopes | 2002 |
Possible participation of intracellular platelet-activating factor in NF-kappaB activation in rat peritoneal macrophages.
Topics: Animals; Azepines; Base Sequence; Cells, Cultured; DNA Primers; Hydrolysis; Imidazoles; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Organophosphorus Compounds; Phosphorylation; Piperidines; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Thapsigargin; Triazoles | 2002 |
Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist.
Topics: Administration, Oral; Allergens; Animals; Butanols; Capsaicin; Cats; Dogs; Edema; Ferrets; Gerbillinae; Guinea Pigs; Histamine; Kinetics; Malates; Mice; Motor Activity; Neurokinin-1 Receptor Antagonists; Piperidines; Platelet Activating Factor; Rabbits; Receptors, Neurokinin-1; Salivation; Substance P; Time Factors | 2002 |
Effect of a platelet-activating factor antagonist, E5880, on cerebrovasospasm following subarachnoid hemorrhage in a canine double-hemorrhage model.
Topics: Animals; Basilar Artery; Cerebrovascular Circulation; Disease Models, Animal; Dogs; Female; Male; Piperidines; Platelet Activating Factor; Pyridinium Compounds; Subarachnoid Hemorrhage; Time Factors; Vasoconstriction; Vasospasm, Intracranial | 2002 |
Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstriction.
Topics: Aerosols; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Disease Models, Animal; Eosinophils; Guinea Pigs; Immunization, Passive; Male; Methacholine Chloride; Piperidines; Platelet Activating Factor; Quinuclidines; Substance P; Water | 2003 |
Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis.
Topics: Animals; Azepines; Chemokines; Endothelin Receptor Antagonists; Endothelin-1; Indoles; Interleukin-1; Mice; Neutrophils; Oligopeptides; Peritonitis; Piperidines; Platelet Activating Factor; Time Factors; Uric Acid | 2004 |
Formation of spherical micelles composed of the novel platelet activating factor receptor antagonist, E5880.
Topics: Algorithms; Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Lipids; Micelles; Particle Size; Piperidines; Platelet Activating Factor; Pyridinium Compounds; Surface Properties | 2005 |
Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice.
Topics: Animals; Antihypertensive Agents; Bronchial Hyperreactivity; Carbachol; Endothelin B Receptor Antagonists; Endothelin-1; Endothelins; Male; Mice; Mice, Inbred BALB C; Oligopeptides; Ovalbumin; Peptide Fragments; Phospholipid Ethers; Piperidines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptor, Endothelin B; Thromboxane A2 | 2007 |
Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models.
Topics: Animals; Capillary Permeability; Cells, Cultured; Chemotaxis, Leukocyte; Conjunctiva; Conjunctivitis, Allergic; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; Leukotriene B4; Male; Mast Cells; Ovalbumin; Peritoneal Cavity; Piperidines; Platelet Activating Factor; Pyridines; Rats; Rats, Wistar | 2010 |