1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with ozagrel in 29 studies
| Studies (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Trials (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Recent Studies (post-2010) (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Studies (ozagrel) | Trials (ozagrel) | Recent Studies (post-2010) (ozagrel) |
|---|---|---|---|---|---|
| 9,156 | 187 | 552 | 529 | 31 | 37 |
| Protein | Taxonomy | 1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50) | ozagrel (IC50) |
|---|---|---|---|
| cystic fibrosis transmembrane conductance regulator | Homo sapiens (human) | 3.43 | |
| Thromboxane-A synthase | Homo sapiens (human) | 0.0864 | |
| Thromboxane-A synthase | Rattus norvegicus (Norway rat) | 0.2 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (34.48) | 18.7374 |
| 1990's | 18 (62.07) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davenport, NJ; Feuerstein, GZ; Goldstein, RE | 1 |
| Barnes, PJ; Chung, KF; Lötvall, JO; Morikawa, A; Tokuyama, K | 1 |
| Klahr, S; Reyes, AA | 1 |
| Kosugi, T; Minei, S; Nakamura, M; Noguchi, S; Saitoh, S; Shimoji, T | 1 |
| Kinjoh, K; Kosugi, T; Nakamura, M; Saitoh, S | 1 |
| Hamano, S; Ikeda, S; Kikuchi, S; Komatsu, H; Okegawa, T; Takehana, Y | 1 |
| Hamano, S; Ikeda, S; Kikuchi, S; Kojima, M; Komatsu, H; Kusama, H; Okegawa, T; Takehana, Y | 1 |
| Hamano, S; Ikeda, S; Kikuchi, S; Komatsu, H; Kusama, H; Okegawa, T; Takehana, Y | 1 |
| Ikeda, S; Kawasaki, A; Motoishi, M; Nambu, F; Okegawa, T; Omawari, N | 1 |
| Dillon, PK; Durán, WN | 1 |
| Davenport, NJ; Ezra, D; Feuerstein, GZ; Goldstein, RE; Laurindo, FR | 1 |
| Aizawa, H; Chung, KF; Evans, TW; Leikauf, GD; Nadel, JA; Ueki, IF | 1 |
| Hattori, Y; Levi, R | 1 |
| Borgeat, P; Braquet, P; Etienne, A; Sirois, P; Touvay, C; Vilain, B | 1 |
| Arroyave, JL; Gonzalez-Crussi, F; Hsueh, W | 2 |
| Azami, K; Hasegawa, T; Hoshi, M; Ohura, T; Ono, I; Tsutsumi, M | 1 |
| Cloutier, S; Jancar, S; Provençal, B; Sirois, P; Thériault, P | 1 |
| Kobayashi, T; Koyama, S; Kusama, S; Toyofuku, T | 1 |
| Chiba, Y; Misawa, M | 1 |
| Iwama, T; Nagai, H; Sakurai, T; Yamaguchi, S | 1 |
| Misawa, M; Sugiyama, Y | 1 |
| Han, SH; Tsai, CF; Tsai, JJ; Wang, SR | 1 |
| Enzan, K; Inaba, H; Kurosawa, S; Yoshioka, N | 1 |
| Kamiya, S; Kanda, M; Kurahashi, K; Matsui, H; Nakamura, S; Shirahase, H; Wada, K | 1 |
| Iwahisa, Y; Kagoshima, M; Kawakami, Y; Terasawa, M; Tomomatsu, N; Yamaguchi, S | 1 |
| Fukuchi, Y; Ishii, S; Katayama, H; Nagase, T; Ouchi, Y; Shimizu, T | 1 |
| Takami, M; Tsukada, W | 1 |
| Gresele, P; Mezzasoma, AM; Venditti, G; Vezza, R | 1 |
29 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and ozagrel
| Article | Year |
|---|---|
In vivo enhancement of platelet activating factor-induced prostacyclin production by OKY-046, a selective inhibitor of thromboxane A2 synthase.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Dose-Response Relationship, Drug; Epoprostenol; Female; Heart Rate; Hemodynamics; Male; Methacrylates; Platelet Activating Factor; Swine; Thromboxane A2; Thromboxane-A Synthase; Vascular Resistance | 1991 |
Role of thromboxane A2 in airway microvascular leakage induced by inhaled platelet-activating factor.
Topics: Administration, Inhalation; Airway Resistance; Animals; Blood Pressure; Capillary Permeability; Dioxanes; Female; Guinea Pigs; Histamine; Methacrylates; Microcirculation; Platelet Activating Factor; Receptors, Prostaglandin; Receptors, Thromboxane; Respiratory System; Thromboxane A2; Thromboxane-A Synthase | 1991 |
Role of platelet-activating factor in renal function in normal rats and rats with bilateral ureteral obstruction.
Topics: Animals; Female; Furans; Glomerular Filtration Rate; Kidney; Methacrylates; Platelet Activating Factor; Radioimmunoassay; Rats; Rats, Inbred Strains; Renal Circulation; Thromboxane A2; Thromboxane-A Synthase; Ureteral Obstruction | 1991 |
Changes in parameters of the coagulation-fibrinolysis system and platelet function after OKY-046 administration to patients with ruptured aneurysm of the cerebral artery.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Blood Coagulation; Blood Platelets; Collagen; Female; Fibrinogen; Fibrinolysis; Humans; Intracranial Aneurysm; Male; Methacrylates; Middle Aged; Plasminogen Inactivators; Platelet Activating Factor; Rupture, Spontaneous; Thromboxane-A Synthase; Tissue Plasminogen Activator | 1991 |
Changes of rabbit platelet function on simultaneous administration of ticlopidine hydrochloride and OKY-046.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arachidonic Acid; Collagen; Drug Interactions; Drug Synergism; Methacrylates; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Statistics as Topic; Ticlopidine | 1991 |
Inhibitory action of OKY-O46.HCl, a specific TXA2 synthetase inhibitor, on platelet activating factor (PAF)-induced airway hyperresponsiveness of guinea pigs: role of TXA2 in development of PAF-induced nonspecific airway hyperresponsiveness.
Topics: Acrylates; Animals; Atropine; Autonomic Nervous System; Calcium Radioisotopes; Guinea Pigs; Hemicholinium 3; Hexamethonium Compounds; Kinetics; Male; Methacrylates; Platelet Activating Factor; Receptors, Adrenergic, beta; Receptors, Muscarinic; Respiratory System; Thromboxane A2; Thromboxane-A Synthase | 1990 |
Effect of a thromboxane A2 synthetase inhibitor (OKY-046.HCl) on airway hyperresponsiveness in guinea pigs.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Airway Resistance; Animals; Antigens; Aspirin; Bronchoalveolar Lavage Fluid; Guinea Pigs; Leukotriene E4; Methacrylates; N-Formylmethionine Leucyl-Phenylalanine; Phthalazines; Physostigmine; Platelet Activating Factor; Propranolol; Respiratory System; SRS-A; Thromboxane B2; Thromboxane-A Synthase | 1990 |
[Inhibitory effects of OKY-046.HCl, a selective thromboxane (TX) A2 synthetase inhibitor, on platelet activating factor (PAF)-induced airway hyperresponsiveness in guinea pigs].
Topics: Acrylates; Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Guinea Pigs; In Vitro Techniques; Male; Methacrylates; Platelet Activating Factor; Thromboxane A2; Thromboxane-A Synthase | 1990 |
Inhibitory effects of OKY-046 on spasmogen-induced bronchoconstrictions in sensitized and non-sensitized guinea pigs.
Topics: Acrylates; Animals; Blood Pressure; Bordetella pertussis; Bronchi; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Leukotrienes; Lung; Male; Methacrylates; Muscle Contraction; Muscle, Smooth; Platelet Activating Factor; Prostaglandin D2; Thromboxane-A Synthase; Trachea | 1990 |
Effect of platelet-activating factor on microvascular permselectivity: dose-response relations and pathways of action in the hamster cheek pouch microcirculation.
Topics: Animals; Benzofurans; Blood Pressure; Capillary Permeability; Cheek; Cricetinae; Dexamethasone; Dextrans; Dose-Response Relationship, Drug; Fluorescein-5-isothiocyanate; Fluoresceins; Hematocrit; Indomethacin; Lignans; Macromolecular Substances; Male; Mesocricetus; Methacrylates; Microcirculation; Platelet Activating Factor | 1988 |
Mechanisms of hypotension produced by platelet-activating factor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Female; Hypotension; Indomethacin; Male; Methacrylates; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Swine; Thromboxane A2; Thromboxane-A Synthase | 1989 |
Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation.
Topics: Animals; Bronchi; Dogs; In Vitro Techniques; Leukotriene B4; Methacrylates; Neutrophils; Platelet Activating Factor; Respiratory System; Thromboxanes | 1986 |
Effect of PGD2 on cardiac contractility: a negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action.
Topics: Animals; Coronary Circulation; Coronary Vessels; Cyclic AMP; Depression, Chemical; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Methacrylates; Myocardial Contraction; Platelet Activating Factor; Prostaglandin D2; Prostaglandins D; SRS-A; Stimulation, Chemical; Vasoconstriction | 1986 |
Characterization of platelet activating factor (PAF)-acether-induced contractions of guinea-pig lung strips by selected inhibitors of arachidonic acid metabolism and by PAF-acether antagonists.
Topics: Animals; Aspirin; Benzofurans; Chromones; Diterpenes; Ginkgolides; Guinea Pigs; Histamine; Imidazoles; Lactones; Leukotriene B4; Lignans; Lung; Male; Methacrylates; Muscle Contraction; Muscle, Smooth; Plant Extracts; Platelet Activating Factor; Prostaglandin Antagonists; Pyrilamine; SRS-A | 1986 |
Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis.
Topics: Alprostadil; Animals; Blood Pressure; Catechols; Chromones; Diethylcarbamazine; Disease Models, Animal; Hematocrit; Indomethacin; Intestines; Ischemia; Leukocyte Count; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Masoprocol; Methacrylates; Necrosis; Platelet Activating Factor; Rats; Rats, Inbred Strains; Salmonella typhi; Thromboxane-A Synthase; Verapamil | 1986 |
The effect of drugs which affect the arachidonate cascade in burned rabbits.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Coagulation; Blood Platelets; Burns; Epoprostenol; Fibrinolysis; Kidney; Methacrylates; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Thromboxane-A Synthase | 1986 |
Mechanism of action of platelet-activating factor on guinea-pig lung parenchyma strips.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Guinea Pigs; Immunoenzyme Techniques; Lung; Masoprocol; Methacrylates; Muscle Contraction; Platelet Activating Factor; Pyrazoles; Sulfonamides; Thromboxane A2; Thromboxane B2 | 1988 |
Pulmonary vascular response to platelet-activating factor in conscious sheep.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Cardiac Output; Lymph; Methacrylates; Platelet Activating Factor; Pulmonary Circulation; Reference Values; Sheep; Thromboxane B2; Thromboxane-A Synthase; Vascular Resistance | 1988 |
Release of leukotriene C4 by isolated, perfused rat small intestine in response to platelet-activating factor.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Chromones; Dinoprostone; Indomethacin; Intestine, Small; Methacrylates; Perfusion; Platelet Activating Factor; Prostaglandins E; Rats; SRS-A; Thromboxane B2; Vasoconstriction | 1986 |
Inhibition of antigen-induced airway hyperresponsiveness in rats: effects of ozagrel (a thromboxane A2 synthase inhibitor) and of CV-3988 (a platelet activating factor antagonist).
Topics: Acetylcholine; Animals; Antigens, Helminth; Ascaris; Bronchial Hyperreactivity; Dinitrobenzenes; Lung; Male; Methacrylates; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Wistar; Respiration; Thromboxane A2; Thromboxane-A Synthase; Vaccination | 1994 |
Pharmacological studies of platelet-activating factor (PAF)-induced augmentation of response to histamine in guinea-pigs.
Topics: Animals; Benzoquinones; Bridged Bicyclo Compounds; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Capillary Permeability; Chromones; Drug Interactions; Fatty Acids, Monounsaturated; Guinea Pigs; Histamine; Indomethacin; Leukocyte Count; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Methacrylates; Phospholipid Ethers; Platelet Activating Factor; Pressure; Respiratory Physiological Phenomena; Respiratory System; Thromboxane A2 | 1994 |
An airway hyperresponsiveness model in rat allergic asthma.
Topics: Acetylcholine; Animals; Ascaris; Asthma; Bronchial Hyperreactivity; Capillary Permeability; Chromones; Depression, Chemical; Dinitrophenols; Disease Models, Animal; Male; Methacrylates; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Wistar; SRS-A; Thromboxane-A Synthase; Tissue Extracts | 1993 |
The modulatory effect of antigen- and PAF-induced asthmatic reaction by aerosol administration of OKY-046 in guinea pigs.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Dose-Response Relationship, Drug; Guinea Pigs; Histamine Antagonists; Male; Methacrylates; Ovalbumin; Platelet Activating Factor; Thromboxane-A Synthase; Time Factors | 1995 |
Thromboxane rather than platelet activating factor mediates pulmonary vasoconstriction after antigen challenge in rabbits.
Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Enzyme Inhibitors; Humans; Immunization; Indomethacin; Lung; Methacrylates; Platelet Activating Factor; Pulmonary Artery; Pulmonary Circulation; Pyridinium Compounds; Rabbits; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction | 1996 |
Effects of 1-[3-(4-benzhydryl-1-piperazinyl)propyl]-3- (1H-imidazol-1-ylmethyl)-1H-indole-6-carboxylic acid with thromboxane A2 synthetase inhibitory and H1-blocking activities on anaphylactic bronchospasm.
Topics: Anaphylaxis; Animals; Bronchial Spasm; Bronchoconstriction; Enzyme Inhibitors; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Indoles; Leukotriene D4; Lung; Male; Methacrylates; Platelet Activating Factor; Rabbits; Thromboxane A2; Thromboxane-A Synthase; Trachea | 1996 |
Effects of Y-24180, a long-acting and potent antagonist to platelet-activating factor, on immediate asthmatic response in guinea pigs.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Azepines; Benzoquinones; Bronchodilator Agents; Chromones; Drug Interactions; Drug Therapy, Combination; Guinea Pigs; Heptanoic Acids; Male; Methacrylates; Platelet Activating Factor; Theophylline; Triazoles | 1997 |
Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes.
Topics: Animals; Azepines; Bronchi; Bronchial Hyperreactivity; Chromones; Indoles; Indomethacin; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Lung; Methacrylates; Mice; Mice, Transgenic; Phenylpropionates; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Leukotriene B4; Thromboxanes; Triazoles | 1997 |
Effect of DP-1904, a thromboxane synthetase inhibitor, on antigen- and spasmogen-induced bronchoconstriction in rodents.
Topics: Acetylcholine; Animals; Antigens; Arachidonic Acid; Bradykinin; Bronchoconstriction; Bronchoconstrictor Agents; Enzyme Inhibitors; Guinea Pigs; Histamine; Histamine H1 Antagonists; Imidazoles; Indomethacin; Leukotriene D4; Male; Methacrylates; Platelet Activating Factor; Pyrilamine; Rats; Rats, Sprague-Dawley; Tetrahydronaphthalenes; Thromboxane-A Synthase | 1999 |
Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Biphenyl Compounds; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Cells, Cultured; Enzyme Inhibitors; Fatty Acids, Unsaturated; Heptanoic Acids; Humans; Hydrazines; Imidazoles; Inositol Phosphates; Kidney; Methacrylates; Phenylacetates; Platelet Activating Factor; Platelet Activation; Prostaglandin H2; Prostaglandins H; Protein Isoforms; Receptors, Thromboxane; Recombinant Fusion Proteins; Sulfonamides; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 2002 |