1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with n-formylmethionine leucyl-phenylalanine in 477 studies
| Studies (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Trials (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Recent Studies (post-2010) (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Studies (n-formylmethionine leucyl-phenylalanine) | Trials (n-formylmethionine leucyl-phenylalanine) | Recent Studies (post-2010) (n-formylmethionine leucyl-phenylalanine) |
|---|---|---|---|---|---|
| 9,156 | 187 | 552 | 6,716 | 53 | 356 |
| Protein | Taxonomy | 1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50) | n-formylmethionine leucyl-phenylalanine (IC50) |
|---|---|---|---|
| fMet-Leu-Phe receptor | Homo sapiens (human) | 0.02 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 116 (24.32) | 18.7374 |
| 1990's | 292 (61.22) | 18.2507 |
| 2000's | 61 (12.79) | 29.6817 |
| 2010's | 8 (1.68) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bates, ME; Busse, WW; Geiger, K; Sedgwick, JB; Vrtis, RF; Zoratti, EM | 1 |
| Bratton, DL; Clay, KL; Dreyer, E; Fadok, VA; Henson, PM; Kailey, JM | 1 |
| Hugli, TE; Jagels, MA | 1 |
| Filep, JG; Földes-Filep, E; Sirois, P | 1 |
| Holgate, ST; Morland, CM; Roche, WR; Wilson, SJ | 1 |
| Cromwell, O; Kay, AB; Kurihara, K; Sehmi, R; Waltmann, P; Wardlaw, AJ | 1 |
| Breslow, R; Castillo, R; Lear, C; Ludwig, JC; McManus, LM; Pinckard, RN; Showell, HJ; Woodard, DS | 1 |
| Coëffier, E; Hidi, R; Vargaftig, BB | 1 |
| Abbas, MK; Carolan, EJ; Casale, TB | 1 |
| Mabuchi, K; Masuzawa, Y; Ojima-Uchiyama, A; Sugiura, T; Waku, K | 1 |
| Bach, MK; Brashler, JR; Petzold, EN; Sanders, ME | 1 |
| Carolan, EJ; Casale, TB | 1 |
| Müller, S; Nigam, S | 3 |
| Askaa, J; Bjerrum, OW; Borregaard, N; Kjeldsen, L | 1 |
| Jacobson, DP; O'Flaherty, JT; Redman, JF | 1 |
| Schatz-Munding, M; Ullrich, V | 1 |
| Bass, DA; Bauldry, SA; Elsey, KL | 1 |
| Imaizumi, A; Kadiri, C; Leduc, D; Lefort, J; Vargaftig, BB | 1 |
| Bachelet, M; Barre, A; Chouaid, C; Havet, N; Housset, B; Masliah, J; Vargaftig, BB | 1 |
| Asako, H; Granger, DN; Korthuis, RJ; Wolf, RE | 1 |
| Ono, S; Voelkel, NF; Westcott, JY | 1 |
| Joseph, S; MacDermot, J | 1 |
| Ito, S; Mikawa, H; Tsuruta, S | 2 |
| Hayashi, M; Imai, Y; Naraba, H; Oh-ishi, S; Omura, S; Tomoda, H | 1 |
| Bewtra, AK; Hopp, RJ; Miyagawa, H; Nabe, M; Okada, C; Townley, G | 1 |
| Alvarez, J; García-Sancho, J; Montero, M | 4 |
| Caramelo, C; Egido, J; Escanero, J; Gómez-Garre, D; González, E; Guerra, M; López-Farré, A; Riesco, A | 1 |
| Blackburn, WD; Chatham, WW; Heck, LW | 2 |
| Chilton, FH; Hubbard, WC; Schleimer, RP; Tomioka, K; Triggiani, M | 1 |
| Javors, MA; Olson, MS; Zhou, W | 2 |
| Tai, HH; Wang, C | 1 |
| Dürr, U; Grimminger, F; Seeger, W | 1 |
| Alison, MR; Antoniw, JW; Garvey, B; Maseri, A; Tippins, JR | 1 |
| Baggiolini, M; Bazzoni, F; Berton, G; Cassatella, MA; Ceska, M; Ferro, I | 1 |
| Bewtra, AK; Hopp, RJ; Miyagawa, H; Nair, NM; Okada, C; Sugiyama, H; Townley, RG | 1 |
| Andersson, PB; Gordon, S; Perry, VH | 1 |
| Kantorski, J; Tchórzewski, H | 1 |
| Baggiolini, M; Dahinden, CA; de Weck, AL; Wirthmueller, U | 1 |
| Bruijnzeel, PL; Koenderman, L; Kok, PT; Kreukniet, J; Warringa, RA | 1 |
| Akutagawa, H; Kim, KM; Mayumi, M; Mikawa, H; Morita, M; Nambu, M; Ohshima, Y; Uenoyama, Y | 1 |
| Jacobson, DP; O'Flaherty, JT; Redman, JF; Rossi, AG | 3 |
| Borgeat, P; Palmantier, R | 2 |
| Aktories, K; Grimminger, F; Just, I; Seeger, W; Sibelius, U | 1 |
| Aktories, K; Grimminger, F; Seeger, W; Sibelius, U; Suttorp, N | 1 |
| Ferro, TJ; Hocking, DC; Johnson, A | 1 |
| Hagenlocker, BE; Owens, CA; Seiler, AJ; Walker, BA; Ward, PA | 1 |
| Gay, JC; Murray, JJ | 1 |
| Hirafuji, M; Shinoda, H | 1 |
| Braun, M; Bruch, L; Ney, P; Schrör, K; Szymanski, C | 1 |
| Didsbury, J; Snyderman, R | 1 |
| Ernest, MJ; Fruman, DA; Gamache, DA | 1 |
| Harris, T; Stewart, AG | 1 |
| Del Vecchio, PJ; Denholm, EM; Fisher, MA; Lai, L; Malik, AB; Palace, GP | 1 |
| Arita, H; Hanasaki, K; Kato, T; Kishino, J | 1 |
| Rihoux, JP | 1 |
| Hartnell, A; Kay, AB; Moqbel, R | 1 |
| Brunner, T; Dahinden, CA; de Weck, AL | 1 |
| Cramer, R; Dri, P; Patriarca, P; Romano, M; Spessotto, P | 1 |
| Flower, RJ; Peers, SH | 1 |
| Alexander, JW; Noel, JG; Ogle, CK; Ogle, JD; Sramkoski, RM | 1 |
| Ikemura, T; Ino, M; Matsumoto, M; Miwa, M; Okamoto, Y; Saito, K; Sugatani, J; Suzuki, Y | 1 |
| Alessi, D; Bussolino, F; Camussi, G; Turello, E | 1 |
| Hasegawa, Y; Kunow, E; Shindou, J; Yuki, H | 1 |
| Maeyama, K; Sasaki, M; Watanabe, T | 1 |
| Misso, NL; Passarelli, M; Phillips, MJ; Thompson, PJ | 1 |
| Maruyama, S; Uchiyama, S; Yamazaki, M | 1 |
| Anderson, GP; Hultkvist-Bengtsson, U; Kings, M; Morley, J | 1 |
| Bass, DA; Bauldry, SA; Cousart, SL; McCall, CE | 1 |
| DeNichilo, MO; Lopez, AF; Stewart, AG; Vadas, MA | 1 |
| Distler, A; Fassbender, M; Hilgenstock, G; Seifert, R | 1 |
| Hagenlocker, BE; Walker, BA; Ward, PA | 2 |
| Kanaho, Y; Kanoh, H; Nozawa, Y; Saitoh, K | 1 |
| Bass, DA; Bauldry, SA; Wykle, RL | 1 |
| Bry, K; Hallman, M | 1 |
| Brain, SD; Buckley, TL; Rampart, M; Williams, TJ | 1 |
| Geffner, JR; Isturiz, MA; Lazzari, MA; Schattner, MA | 1 |
| Ginsel, LA; Kuijpers, TW; Onderwater, JJ; Roos, D; Tool, AT; van der Schoot, CE; Verhoeven, AJ | 1 |
| Bischoff, SC; Dahinden, CA; De Weck, AL; Takafuji, S | 1 |
| Agrawal, DK; Bewtra, AK; Hopp, RJ; Miyagawa, H; Okada, C; Sugiyama, H; Townley, RG | 1 |
| Naps, MS; Rubin, RP; Thompson, RH | 1 |
| Di Marzo, V; Galadari, SH; Morris, HR | 1 |
| Kownatzki, E; Uhrich, S | 1 |
| Gay, JC | 2 |
| Jacob, HS; Moldow, CF; Vercellotti, GM; Wickham, NW | 1 |
| Lerner, R; Lindström, P; Palmblad, J; Patarroyo, M | 1 |
| Fontán, PA; Geffner, JR; Isturiz, MA; Sordelli, DO | 1 |
| Brown, EJ; Rosales, C | 1 |
| Lefort, J; Lellouch-Tubiana, A; Terlain, B; Vannier, E; Vargaftig, BB | 1 |
| Baggiolini, M; Dahinden, CA; Deranleau, DA; Kernen, P; Spry, CJ; Tai, PC; von Tscharner, V; Wymann, MP | 1 |
| Hirasawa, N; Mue, S; Ohuchi, K; Omata, M; Sugidachi, A; Tsurufuji, S; Watanabe, M | 1 |
| Agrawal, DK; Bewtra, AK; Gordy, C; Hopp, RJ; Miyagawa, H; Nabe, M; Okada, C; Sugiyama, H; Townley, RG | 1 |
| Ebisawa, M; Iikura, Y; Saito, H | 1 |
| Béréziat, G; Cherqui, G; Etienne, J; Kadiri, C; Masliah, J; Rybkine, T | 1 |
| Christophers, E; Morita, E; Schröder, JM | 2 |
| Lim, WH; Stewart, AG | 1 |
| Edwards, RJ; MacDermot, J; Storch, J | 1 |
| Bazzoni, G; Bertelé, V; Del Maschio, A; Prosdocimi, M; Zatta, A | 1 |
| Chambaut-Guerin, AM; Delbourg, I; Ribier, A; Thomopoulos, P; Ventura, MA | 1 |
| Austinhirst, R; Snyder, F; Vallari, DS | 1 |
| Cerletti, C; Chen, ZM; De Gaetano, G; Del Maschio, A; Evangelista, V; Rajtar, G | 1 |
| DiPersio, JF; Gasson, JD; Golde, DW | 1 |
| Dubbin, PN; Dusting, GJ; Harris, T; Stewart, AG | 1 |
| Combadière, C; Giroud, JP; Hakim, J; Périanin, A | 1 |
| Barnes, PJ; Giembycz, MA; Kroegel, C | 1 |
| Keenan, CM; Wallace, JL | 1 |
| Hecker, G; Ney, P; Schrör, K | 1 |
| Bessler, WG; Hauschildt, S; Jung, G; Metzger, J; Richter-Freund, M; Schultz, G; Seifert, R; Wiesmüller, KH | 1 |
| Dahinden, CA; de Weck, AL; Wirthmueller, U | 2 |
| Brohult, J; Palmblad, J; Samuelsson, J | 1 |
| Tai, HH; Tanizawa, H | 2 |
| Hamano, S; Ikeda, S; Kikuchi, S; Kojima, M; Komatsu, H; Kusama, H; Okegawa, T; Takehana, Y | 1 |
| Gleich, GJ; Moy, JN; Thomas, LL | 1 |
| Beauseigle, D; Gilbert, C; McColl, SR; Naccache, PH | 1 |
| Bertoli, E; Curatola, G; Fiorini, R; Giorgi, PL; Kantar, A | 1 |
| Bonak, VA; Caon, AC; Gaudry, M; Gilbert, C; Huang, CK; McColl, SR; Naccache, PH; Umezawa, K | 1 |
| Huu, TP; Perianin, A; Stanislawski, L | 1 |
| Champion, A; Cromwell, O; Kay, AB; Moqbel, R; Osei, D; Wardlaw, AJ | 1 |
| Håkansson, L; Venge, P | 1 |
| Bala, GA; Bleasdale, JE; Bundy, GL; Justen, JM; Sam, LM; Smith, RJ | 1 |
| Bassot, S; Chignard, M; Ferrer-Lopez, P; Laurent, P; Renesto, P; Schattner, M | 1 |
| Brachmann, P; Brandes, C; Gängler, P; Hoffmann, T; Krause, S; Lösche, W | 1 |
| Strøm, H; Thomsen, MK | 1 |
| Brain, SD; Williams, TJ | 1 |
| Håkansson, L; Venge, P; Westerlund, D | 1 |
| Belch, JJ; Forbes, CD; Saniabadi, AR | 1 |
| Gustafson, KS; Jacob, HS; Nelson, RD; Vercellotti, GM; Yin, HQ | 1 |
| Agwu, DE; McCall, CE; McPhail, LC; Wykle, RL | 1 |
| Molski, TF; Sha'afi, RI; Tao, W | 1 |
| DiPersio, JF; Gasson, JC; Kaufman, SE | 1 |
| Armstrong, ML; Harrison, DG; Heistad, DD; Lopez, JA; Piegors, DJ | 1 |
| Durstin, M; Gomez-Cambronero, J; Molski, TF; Naccache, PH; Sha'afi, RI | 1 |
| McIntyre, TM; Prescott, SM; Reinhold, SL; Zimmerman, GA | 1 |
| Kariya, T; Kume, S; Matsumoto, Y; Ozaki, Y; Yatomi, Y | 1 |
| Capron, A; Capron, M; De Vos, C; Joseph, M; Leprevost, C; Tomassini, M; Vorng, H | 1 |
| Hallam, TJ; Jacob, R; Merritt, JE | 1 |
| Johnson, KJ; Mandel, DM; Ward, PA; Warren, JS | 1 |
| Laplante, C; Marceau, F; Tremblay, B | 1 |
| Böhme, E; Schmidt, HH; Seifert, R | 1 |
| Filep, J; Földes-Filep, E | 1 |
| Kownatzki, E; Neumann, M | 1 |
| Fitzgerald, MF; Parente, L; Whittle, BJ | 1 |
| Bachelet, M; Béréziat, G; Kadiri, C; Masliah, J; Vargaftig, BB | 1 |
| Burde, R; Schultz, G; Seifert, R | 1 |
| Phillips, WA; Stewart, AG | 1 |
| Stewart, AG | 1 |
| Fehr, J; Moser, R; Patarroyo, M; Schleiffenbaum, B | 1 |
| Koenderman, L; Roos, D; Tool, A; Verhoeven, AJ | 1 |
| Bachelet, M; Vermeer, MA; Vincent, JE; Zijlstra, FJ | 1 |
| Bern, MJ; Berschneider, HM; Karayalcin, SS; Powell, DW; Sturbaum, CW; Wachsman, JT | 1 |
| Chap, H; Gelas, P; Record, M; Ribbes, G; Terce, F | 1 |
| Bruijnzeel, PL; Koenderman, L | 1 |
| Boukili, MA; Bureau, MF; Malanchere, E; Pretolani, M; Vargaftig, BB | 1 |
| Baggiolini, M; Deranleau, DA; Dewald, B; Kernen, P; von Tscharner, V; Wymann, MP | 1 |
| Becker, EL; Gomez-Cambronero, J; Molski, TF; Sha'afi, RI | 1 |
| Clay, KL; Guthrie, LA; Johnston, RB; Seccombe, JF; Worthen, GS | 1 |
| Justen, JM; Sam, LM; Smith, RJ | 2 |
| Lerner, R; Lindström, P; Palmblad, J | 1 |
| Baggiolini, M; Thelen, M; Wolf, M | 1 |
| Crooke, ST; Foley, JJ; Mong, S; Sarau, HM; Winkler, JD | 1 |
| Grinstein, S; Nasmith, PE | 1 |
| Ng, DS; Wong, K | 1 |
| Benveniste, J; Coëffier, E; Desquand, S; Floch, A; Lefort, J; Maridonneau-Parini, I; Randon, J; Sedivy, P; Vargaftig, BB | 1 |
| MacIntyre, DE; McMillan, RM; Rossi, AG | 1 |
| Caravella, SJ; Clark, DA; McNeill, H; Miller, MJ; Mullane, KM | 1 |
| Errasfa, M; Fradin, A; Poincelot-Canton, B; Rothhut, B; Russo-Marie, F | 1 |
| Aratani, H; Maruyama, Y; Nishida, Y; Terasawa, M | 1 |
| Nakamura, T; Nishizawa, Y; Sato, T; Yamato, C | 1 |
| Koenderman, L; Roos, D; Verhoeven, AJ; Yazdanbakhsh, M | 1 |
| Issekutz, AC; Ripley, M | 1 |
| Capron, A; Capron, M; De Vos, C; Leprevost, C; Tomassini, M | 1 |
| O'Flaherty, JT | 1 |
| Baggiolini, M; Dewald, B | 3 |
| Becker, EL; Molski, MM; Naccache, PH; Sha'afi, RI; Volpi, M | 1 |
| Lagente, V; Lefort, J; Maridonneau-Parini, I; Randon, J; Russo-Marie, F; Vargaftig, BB | 1 |
| Bruynzeel, PL; Hamelink, ML; Kijne, AM; Kok, PT; Verhagen, J | 1 |
| Issekutz, AC; Ripley, M; Rochon, Y | 1 |
| Beckman, JK; Gay, JC; Lukens, JN; Zaboy, KA | 1 |
| Klein-Knoeckel, D; Zimmerman, GA | 1 |
| Becker, EL | 1 |
| Becker, EL; Huang, CK; Kermode, JC; Marsh, ML; Munoz, JJ; Naccache, PH; Sha'afi, RI; Yassin, R | 1 |
| Niwa, Y; Ohashi, T; Ozaki, Y | 1 |
| Becker, EL; Kanaho, Y; Matsumoto, T; Molski, TF; Sha'afi, RI | 1 |
| Bodmer, JL; Bray, MA; McKearn-Smith, C; Metz-Virca, G; Virca, GD | 1 |
| Akerman, KE; Hartiala, KT; Scott, IG; Viljanen, MK | 1 |
| Bureau, M; Joseph, D; Vargaftig, BB | 1 |
| Molski, TF; Sha'afi, RI | 1 |
| Augustine, NH; Hill, HR; McFall, TL; Zimmerman, GA | 1 |
| Baehner, RL; Boxer, LA; Ingraham, LM; Lafuze, JE | 1 |
| Bitter-Suermann, D; Englberger, W; Hadding, U | 1 |
| Baggiolini, M; Deranleau, DA; von Tscharner, V; Wymann, MP | 1 |
| Adkinson, NF; Davidson, DA; Lichtenstein, LM; Schleimer, RP | 1 |
| Ho, YS; Lee, WM; Snyderman, R | 1 |
| Maudsley, DJ; Morris, AG | 1 |
| Oda, M; Saito, K; Satouchi, K | 1 |
| Dabiri, GA; Shalit, M; Southwick, FS | 1 |
| Coëffier, E; Joseph, D; Prévost, MC; Vargaftig, BB | 1 |
| Bochner, BS; Brown, KE; Peachell, PT; Schleimer, RP | 1 |
| Maclouf, J; Pradelles, P; Robidoux, C; Sirois, P | 1 |
| Billah, MM; Egan, RW; Pai, JK; Siegel, MI | 2 |
| Fortes, ZB; Garcia-Leme, J; Lagente, V; Vargaftig, BB | 1 |
| Gay, JC; Stitt, ES | 1 |
| Bass, DA; McCall, CE; McPhail, LC; Morris-Natschke, S; Schmitt, JD; Wykle, RL | 1 |
| Cain, P; Lewis, MS; McIntyre, TM; Prescott, SM; Whatley, RE; Zimmerman, GA | 1 |
| Becker, EL; Molski, TF; Sha'afi, RI; Tao, W | 1 |
| Henson, PM; Kimani, G; Tonnesen, MG | 1 |
| Bruijnzeel, PL; Hamelink, ML; Koenderman, L; Kok, PT; Verhoeven, AJ | 1 |
| Chignard, M; Selak, MA; Smith, JB | 1 |
| Angle, MJ; McManus, LM; Pinckard, RN | 1 |
| Granger, HJ; Lewis, RE | 1 |
| Rampart, M; Williams, TJ | 1 |
| Grewal, IS; Lad, PM; Olson, CV | 1 |
| Conrad, GW; Rink, TJ | 1 |
| Bruynzeel, PL; Hameling, ML; Koenderman, L; Kok, PT; Verhagen, J | 1 |
| Oda, M; Saito, K; Satouchi, K; Yasunaga, K | 1 |
| Issekutz, AC; Szpejda, M | 1 |
| Hoppens, CL; Ludwig, JC; McManus, LM; Mott, GE; Pinckard, RN | 1 |
| Colditz, IG; Movat, HZ | 2 |
| Thomson, DM | 1 |
| Lees, CJ; McCall, CE; O'Flaherty, JT; Shewmake, T; Thomas, MJ; Wykle, RL | 1 |
| Hammett, MJ; Love, SH; McCall, CE; O'Flaherty, JT; Shewmake, TB; Thomas, MJ; Wykle, RL | 1 |
| Baehner, RL; Boxer, LA; Yasaka, T | 1 |
| Allen, JM; Baehner, RL; Boxer, LA; Coates, TD; Higgins, CP; Ingraham, LM | 1 |
| Bowman, BJ; Iden, SS; Smith, RJ | 2 |
| Carroll, C; Hammett, MJ; McCall, CE; O'Flaherty, JT; Thomas, MJ; Wykle, RL | 1 |
| Lee, T; Lenihan, DJ; Malone, B; Roddy, LL; Wasserman, SI | 1 |
| Clark, PO; Hanahan, DJ; Ludwig, JC; McManus, LM; Pinckard, RN | 1 |
| McCall, CE; O'Flaherty, JT; Schmitt, JD; Wykle, RL | 1 |
| Goetzl, EJ; Valone, FH | 1 |
| Boukedes, SS; Campbell, EJ; Campbell, MA; Owen, CA | 2 |
| Au, BT; Collins, PD; Williams, TJ | 1 |
| Anderson, HC; Bainton, DF; Borregaard, N; Diamond, MS; Kishimoto, TK; Kjeldsen, L; Sengeløv, H; Springer, TA | 1 |
| Cotterill, T; Harris, T; Stewart, AG | 1 |
| Maclouf, J; Pretolani, M; Vargaftig, BB; Zuany-Amorim, C | 1 |
| Newton, RC; Vaddi, K | 1 |
| Columbo, M; Horowitz, EM; Kagey-Sobotka, A; Lichtenstein, LM | 1 |
| Bodlaj, R; Glaubitt, SI; Hübner, C; Krombach, F; Lehr, HA; Messmer, K; Münzing, S; Seiffge, D; von Andrian, UH | 1 |
| Lorant, DE; McEver, RP; McIntyre, TM; Moore, KL; Prescott, SM; Zimmerman, GA | 1 |
| Burns, AR; Gopalan, PK; Lynam, EB; Simon, SI; Sklar, LA; Smith, CW; Taylor, AD | 1 |
| Hirai, K; Iida, M; Ito, K; Kasahara, T; Miyamasu, M; Morita, Y; Ohta, K; Ohtoshi, T; Takahashi, Y; Takaishi, T | 1 |
| Dahinden, CA; Ito, K; Tadokoro, K; Takafuji, S | 1 |
| Bindi, D; Franchi-Micheli, S; Gentilini, G; Mugnai, S; Zilletti, L | 1 |
| Ahmed, K; Campbell, KD; Skubitz, AP; Skubitz, KM | 1 |
| Aoki, Y; Kodama, H; Matsumoto, T; Nakamura, M; Noma, M; Shimizu, T | 1 |
| Akiba, S; Fujii, T; Hashizume, T; Naka, M; Sato, T; Sugatani, J | 1 |
| Jacquier-Sarlin, MR; Kantengwa, S; Maridonneau-Parini, I; Polla, BS; Stubbe, H | 1 |
| Banerjee, A; Botha, AJ; Kim, FJ; Moore, EE; Moore, FA; Peterson, VM | 1 |
| Bloemen, PG; Engels, F; Henricks, PA; Nijkamp, FP; van de Velde, MJ | 1 |
| Borgeat, P; Krump, E; Naccache, PH; Pouliot, M | 1 |
| Filep, JG; Földes-Filep, E; Fournier, A | 1 |
| Botana, LM; MacGlashan, D | 1 |
| Bratton, DL | 1 |
| Nigam, S; Svetlov, S | 1 |
| Betts, WH; McLennan, G; Scicchitano, R; Wozniak, A | 1 |
| Baranowski, SL; Burch, RA; Hamann, KJ; Leff, AR; Neeley, SP; White, SR | 1 |
| Lorant, DE; McEver, RP; McIntyre, TM; Prescott, SM; Topham, MK; Whatley, RE; Zimmerman, GA | 1 |
| Bickel, CA; Bochner, BS; Kaiser, J; Schleimer, RP | 1 |
| Blardi, P; Capecchi, PL; Ceccatelli, L; De Lalla, A; Di Perri, T; Pasini, L; Volpi, L | 1 |
| Turner, NC; Wood, LJ | 1 |
| Das, A; Larkin, SW; Nourshargh, S; Williams, TJ | 1 |
| Bratt, J; Lerner, R; Palmblad, J; Ringertz, B | 1 |
| Eskafi, S; Müller, S; Nigam, S; Zhang, H | 1 |
| Colotta, F; Fadlon, EJ; Mantovani, A; Matteucci, C; Orlando, S; Sozzani, S | 1 |
| Schröder, JM; Schwenk, U | 1 |
| Casale, TB; Erger, RA | 1 |
| Blom, M; Knol, EF; Mul, FP; Roos, D; Tool, AT; Verhoeven, AJ | 1 |
| Bates, PJ; Brutinel, WM; Kreofsky, TJ; Limper, AH; Rohrbach, MS; Specks, U | 1 |
| Imanishi, N; Koike, H; Morooka, S; Natsume, Y | 1 |
| Abe, T; Matsuda, K; Nagai, H; Omata, T; Segawa, Y; Yoshida, K | 1 |
| de la Cruz, C; de Nicoläs, R; Egido, J; González, E; Herrero-Beaumont, G | 1 |
| Bienvenu, K; Granger, DN; Harris, N | 1 |
| Daniels, RH; Elmore, MA; Finnen, MJ; Hill, ME; Lackie, JM; Shimizu, Y | 1 |
| Blackburn, WD; Chatham, WW; Turkiewicz, A | 1 |
| Alverez, J; Garcia-Sancho, J; Montero, M | 1 |
| Cordes, JF; O'Flaherty, JT | 1 |
| Bignold, LP; Harkin, DG | 1 |
| Borgeat, P; Braquet, P; McColl, SR; McDonald, PP | 1 |
| Borgeat, P; Krump, E | 1 |
| Lee, TH; Soyombo, O; Spur, BW | 1 |
| Banerjee, A; Carl, VS; Kim, FJ; Koike, K; Moore, EE; Moore, FA | 1 |
| Foster, M; Gueremy, T; Turner, NC; Wood, LJ | 1 |
| Antosiewicz, J; Bertoli, E; Fiorini, R; Kantar, A; Tanfani, F; Tartaglini, E; Wozniak, M | 1 |
| Cho, SK; Kane, GC; Kim, CJ; Koh, YY; Peters, SP; Zangrilli, JG | 1 |
| Eda, R; Hopp, RJ; Townley, RG | 1 |
| Coburn, JP; Eggleton, P; Ghebrehiwet, B; Sastry, KN; Tauber, AI; Zaner, KS | 1 |
| Engels, F; Henricks, PA; Nijkamp, FP; van de Velde, MJ | 1 |
| de Boer, M; Koenderman, L; Kuijpers, TW; Mascart-Lemone, F; Roos, D; van Zwieten, R; Verhoeven, AJ | 1 |
| Evangelista, V; Locati, M; Luini, W; Mantovani, A; Sozzani, S; Zhou, D | 1 |
| Iwamoto, I; Kawashima, T; Nakagawa, N; Tomioka, H; Yoshida, S | 1 |
| Connelly, PA; Farrell, CA; Richard, S; Shaw, AS; Showell, HJ | 1 |
| Hakim, J; Pedruzzi, E; Périanin, A | 1 |
| Marshall, CJ; Saklatvala, J; Thompson, HL | 1 |
| Borgeat, P; Braquet, P; Palmantier, R; Sanchez, A; Surette, ME | 1 |
| duSapin, K; Hagar, AF; Spitzer, JA | 1 |
| Akutagawa, H; Mayumi, M; Mikawa, H; Morita, M; Nambu, M; Ohshima, Y; Uenoyama, Y | 1 |
| Alvarez, J; Garcia Rodriguez, C; García-Sancho, J; Montero, M; Sánchez Crespo, M | 1 |
| Grinstein, S; Laneuville, O; Nigam, S; Pace-Asciak, CR; Reynaud, D | 2 |
| Frojmovic, MM; Rochon, YP | 1 |
| Bewtra, AK; Eda, R; Hopp, RJ; Okada, C; Sugiyama, H; Townley, RG | 1 |
| Becker, I; Huber, W; Peskar, BM; Schenck, U; Schepp, W; Trautmann, M | 1 |
| Boonen, GJ; de Koster, BM; Elferink, JG | 1 |
| Alonso-Torre, SR; Alvarez, J; García-Sancho, J; Montero, M; Sanchez, A | 1 |
| Jones, CJ; MacIntyre, DE; McMillan, RM; Rossi, AG | 1 |
| Colditz, IG; Mulder, K | 1 |
| Bereziat, G; Levistre, R; Masliah, J | 1 |
| Franson, RC; Lattanzio, KS; Rosenthal, MD | 1 |
| Aramaki, Y; Ichimori, Y; Masuya, H; Nishinaka, Y; Sugawara, T; Yoshida, H | 1 |
| O'Flaherty, JT; Rossi, AG | 1 |
| Heimburger, M; Lerner, R; Palmblad, J | 1 |
| Betts, WH; Murphy, GA; Rokicinski, M; Wozniak, A | 1 |
| Bochner, BS; Lichtenstein, LM; MacGlashan, DW; Schleimer, RP; Tomioka, K | 1 |
| Betz, S; Bruijnzeel, PL; Koenderman, L; Kuijper, PH; Rihs, S; Warringa, RA | 1 |
| Harris, MC; Shalit, M; Southwick, FS | 1 |
| Alvarez, J; Garcia, C; Montero, M; Sanchez Crespo, M | 1 |
| Arreto, CD; Bureau, MF; Imaizumi, A; Vargaftig, BB | 1 |
| Bruijnzeel, PL; Koenderman, L; Mengelers, HJ; Raaijmakers, JA; Warringa, RA | 1 |
| Brattig, NW; Medina-De la Garza, CE; Rubio de Krömer, MT | 1 |
| Samuelsson, J | 1 |
| Tool, AT; Verhoeven, AJ | 1 |
| Pinckard, RN; Prihoda, TJ | 1 |
| Akamatsu, H; Kanoh, T; Kurisaka, M; Niwa, Y; Ozaki, Y | 1 |
| Clough, J; Cypcar, D; Kaplan, M; Lemanske, RF; Nagata, M; Sedgwick, J; Sorkness, R | 1 |
| Hedqvist, P; Lindbom, L; Raud, J; Thorlacius, H; Xie, X | 1 |
| Keicher, U; Koletzko, B; Reinhardt, D | 1 |
| Czarnetzki, BM; Hartmann, K; Pfrommer, C; Schwarz, S; Zuberbier, T | 1 |
| Advani, SH; Bhisey, AN; Kumar, A; Naik, NR; Radhika, V; Thennarasu, S | 1 |
| Ciccarelli, A; Cirillo, R; de Crescenzo, G; de Paulis, A; Marone, G; Patella, V | 1 |
| Bauldry, SA; Wooten, RE | 2 |
| Obata, Y; Oda, M; Yamamoto, N; Yokota, K | 1 |
| de Koster, BM; Elferink, JG | 1 |
| Knol, EF; Lie, WJ; Mul, FP; Roos, D; Verhoeven, AJ | 1 |
| Ito, K; Tadokoro, K; Takafuji, S | 1 |
| Autunes, E; De Nucci, G; Ferreira, HH; Flores, CA; Lima, CS; Medeiros, MV; Sannomiya, P | 1 |
| Ali, H; Haribabu, B; Richardson, RM; Snyderman, R | 1 |
| Chilvers, ER; Condliffe, AM; Dransfield, I; Haslett, C | 1 |
| Antczak, A; Bialasiewicz, P; Krol, M; Nowak, D; Piasecka, G | 1 |
| Hilger, RA; Köller, M; König, W | 1 |
| Ambruso, DR; Cusack, N; Malech, HL; Peterson, VM; Rosenthal, J; Thurman, GW | 1 |
| Chilvers, ER; Condliffe, AM; Haslett, C; Kitchen, E; Rossi, AG | 1 |
| Fukumura, M; Shindo, K | 2 |
| Knol, EF; Liu, L; Lutter, R; Mul, FP; Roos, D | 1 |
| Anderson, R; Feldman, C; Theron, AJ | 1 |
| Buurman, WA; Dentener, MA; Francot, GJ; Hiemstra, PS; Tool, AT; Vandenabeele, P; Verhoeven, AJ | 1 |
| Avdi, NJ; Gerwins, P; Johnson, GL; Knall, C; Nick, JA; Worthen, GS; Young, SK | 1 |
| Ishioka, S; Kambe, M; Kimura, T; Mineshita, M; Moritani, C; Murai, H; Yamakido, M | 1 |
| Eldor, A; Gödeke, ME; Orevi, M; Rigbi, M | 1 |
| Fukumura, M; Hirai, Y; Koide, K; Shindo, K | 1 |
| Hsu, MF; Ko, FN; Lee, TH; Lin, CN; Teng, CM; Wang, JP | 1 |
| Barnett, CC; Moore, EE; Partrick, DA; Silliman, CC | 1 |
| Bjursten, LM; Schmid-Schönbein, GW; Tung, DK; Zweifach, BW | 1 |
| Jackson, CG; Stewart, A; Wakelam, MJ | 1 |
| Antczak, A; Bialasiewicz, P; Krol, M; Nowak, D | 1 |
| Antón, F; Berto, L; Carrasco, E; Cortijo, J; Grau, M; Martí-Cabrera, M; Morcillo, EJ | 1 |
| Barbara, JA; Chilvers, ER; Condliffe, AM; Dransfield, I; Dunkley, SA; Haslett, C; Lopez, AF; Murray, J; Van Ostade, X | 1 |
| Manna, SK; Samanta, AK; Samanta, S | 1 |
| Kohno, S; Nabe, T; Yamamura, H | 1 |
| Alger, LE; Carson, SS; Garland, A; Leff, AR; McAllister, K; Necheles, J; Neeley, SP; Solway, J; White, SR | 1 |
| Elzi, DJ; Hiester, AA; Silliman, CC | 1 |
| Coffer, PJ; Geijsen, N; Koenderman, L; Lammers, JW; M'rabet, L; Maikoe, T; Raaijmakers, JA; Schweizer, RC | 1 |
| Bindi, D; Ciuffi, M; Franchi-Micheli, S; Maurizi, M; Mugnai, S; Zilletti, L | 1 |
| Berend, N; Matheson, MJ; McClean, MA; Rynell, AC | 1 |
| Gamaley, IA; Kirpichnikova, KM; Klyubin, IV | 1 |
| Wise, H | 1 |
| Al-Hage, M; Ezeamuzie, CI | 1 |
| Hallett, MB; Pettit, EJ | 1 |
| Costa, JJ; Delano, FA; Harris, AG; Schmid-Schönbein, GW; Zweifach, BW | 1 |
| Białasiewicz, P; Król, M; Nowak, D | 1 |
| Gajate, C; Lazo, PA; Martín-Martín, B; Mollinedo, F | 1 |
| Buckley, C; Nash, GB; Rainger, GE; Simmons, DL | 1 |
| Kula, P; Kurmanowska, Z; Nowak, D; Stolarek, R | 1 |
| Burke-Gaffney, A; Hellewell, PG | 1 |
| Bos, JL; Coffer, P; Franke, B; Koenderman, L; M'Rabet, L; Segal, AW; Zwartkruis, F | 1 |
| Akard, LP; Cui, Y; English, D; Garcia, JG; Siddiqui, RA | 1 |
| Hajjar, JJ; Molski, TF; Nagarkatti, D; Sha'afi, RI; Syrbu, SI; Waterman, WH | 1 |
| Biffl, WL; Johnson, JL; Moore, EE; Shames, B; Silliman, CC; Tamura, DY; Zallen, G | 1 |
| Bos, JL; Coffer, PJ; Koenderman, L; M'Rabet, L; Wolthuis, RM; Zwartkruis, F | 1 |
| Brown, GE; Burke, PA; Forse, RA; Xu, J; Yaffe, MB | 1 |
| Bueb, JL; Tschirhart, EJ; Zardini, DM | 1 |
| Arnautova, IP; Gamaleĭ, IA; Kirpichnikova, KM; Kliubin, IV | 1 |
| Borregaard, N; Bratt, T; Ohlson, S | 1 |
| Fukuda, S; Predescu, DN; Schmid-Schönbein, GW; Yasu, T | 1 |
| Birnboim, HC; Cowling, RT | 1 |
| Eriksson, EE; Hedqvist, P; Johansson, J; Lindbom, L; Ruoslahti, E; Werr, J | 1 |
| Chen, JS; Chen, LW; Shen, AY; Wu, SN | 1 |
| Gebhard, MM; Herfarth, C; Klar, E; Maksan, SM; Ryschich, E; Schmidt, J; Werner, J | 1 |
| Ebina, Y; Hagi, A; Hayashi, H; Kishi, K; Wang, L | 1 |
| Cromwell, O; Kay, AB; Moqbel, R; Sehmi, R; Wardlaw, AJ | 1 |
| Adams, J; Deitch, EA; Fekete, Z; Garced, M; Hauser, CJ; Livingston, DH | 1 |
| Luu, NT; Nash, GB; Rainger, GE | 1 |
| Boetticher, E; Jacobs, B; Leff, AR; Muñoz, NM; Sano, A; Sano, H; Subbaraman, R; Zhu, X | 1 |
| Gamaley, IA; Ischenko, AM; Kirpichnikova, KM; Klyubin, IV; Zhakhov, AV | 1 |
| Biffl, WL; Ciesla, DJ; Gonzalez, RJ; Moore, EE; Silliman, CC | 1 |
| Calafat, J; Hiemstra, PS; Hordijk, PL; Janssen, H; Mul, FP; Roos, D; van Wetering, S; Zuurbier, AE | 1 |
| Dohi, T; Kitayama, S; Kurihara, H; Mizuno, N; Morita, K; Shibata, K; Shinohara, H; Yoshino, H | 1 |
| Asimakopoulos, G; Haskard, DO; Landis, RC; Taylor, KM | 1 |
| Kindzelskii, AL; Petty, HR | 1 |
| Barr, AJ; Marjoram, RJ; Richardson, RM; Snyderman, R | 1 |
| Aiboshi, J; Ciesla, DJ; Moore, EE; Silliman, CC | 1 |
| Bjornsen, AJ; Elzi, DJ; MacKenzie, T; Silliman, CC; Wyman, TH | 1 |
| Fromme, A; Lechtermann, A; Mooren, FC; Pospiech, S; Thorwesten, L; Völker, K | 1 |
| Blodgett, JL; Bloodworth, RC; McManus, LM; Pinckard, RN; Prihoda, TJ | 1 |
| Al-Ghoul, WM; Choudhry, MA; Fazal, N; Sayeed, MM | 1 |
| Camussi, G; Guida, G; Mariano, F; Tetta, C; Triolo, G | 1 |
| Hanson, AJ; Quinn, MT; Siemsen, DW; Swain, SD | 1 |
| Clay, K; Dinauer, M; Hiran, T; Johnson, C; Travers, J | 1 |
| Backlund, A; Bohlin, L; Claeson, P; Göransson, U; Johansson, S; Luijendijk, T | 1 |
| Drost, EM; MacNee, W | 1 |
| Barabé, F; Bourgoin, SG; Fernandes, MJ; Naccache, PH; Paré, G | 1 |
| Kistler, EB; Mitsuoka, H; Schmid-Schönbein, GW | 1 |
| Anderson, R; Steel, HC | 2 |
| Davies, JE; Ng, LL; Pettit, AI; Wong, RK | 1 |
| Cadwallader, KA; Chilvers, ER; Condliffe, AM; McGregor, A; Stephens, LR; Walker, TR; White, JF | 1 |
| Baker, PR; Daniel, LW; Nixon, AB; O'Flaherty, JT; Owen, JS; Thomas, L; Wooten, R; Wykle, RL | 1 |
| Grandel, U; Grimminger, F; Hattar, K; Hoffmann, S; Mayer, K; Schenkel, A; Seeger, W; Sibelius, U | 1 |
| Buckley, A; Chilvers, ER; Haslett, C; MacKinnon, AC; Rossi, AG; Sethi, T | 1 |
| den Bakker, CG; Durieux, ME; Hollmann, MW; Marcus, MA; Strümper, D; Tröster, B | 1 |
| Brown, RA; Jones, NA; Lever, R; Page, CP | 1 |
| Hanaka, H; Izumi, T; Kato, M; Morikawa, A; Suzuki, M | 1 |
| Ishida, A; Miyakuni, Y; Nakagawa, T; Takafuji, S | 1 |
| Homburg, CH; Knol, EF; Kuijpers, TW; Lie, WJ; Mul, FP; Roos, D; Tool, AT | 1 |
| Gebhard, MM; Herfarth, C; Klar, E; Mayer, H; Ryschich, E; Schmidt, J | 1 |
| Anam, EM; Blázquez, MA; Cerdá-Nicolás, M; Cortijo, J; Estellés, R; Issekutz, AC; Ivorra, MD; López-Martín, J; Martínez-Losa, M; Milian, L; Morcillo, EJ; O'Connor, JE; Sanz, MJ | 1 |
| Chlopicki, S; Gryglewski, RJ; Lomnicka, M | 1 |
| Abe, I; Fukazawa, N; Miwa, M; Noguchi, H; Sugatani, J; Ujihara, K; Yoshinari, K | 1 |
| Bissonnette, SA; Brown, GE; Elia, AE; Stewart, MQ; Wilker, E; Yaffe, MB | 1 |
| Bylund, J; Dahlgren, C; Fu, H; Karlsson, A; Pellmé, S | 1 |
| Abernathy, F; Michail, S | 1 |
| Alteraifi, AM; Chodniewicz, D; Zhelev, DV | 1 |
| Burgos, RA; Concha, II; Cortés, P; Figueroa, J; Hancke, JL; Hidalgo, MA; Romero, A | 1 |
| Gao, XP; Lin, P; Malik, AB; Welch, EJ; Ye, RD | 1 |
| Chen, LW; Hsu, CM; Lin, MW | 1 |
| Bokoch, GM; Zhao, T | 1 |
| Chatterjee, BE; Flower, RJ; Nourshargh, S; Perretti, M; Rosignoli, G; Yona, S; Young, RE | 1 |
| Deitch, EA; Hauser, CJ; Itagaki, K; Kannan, KB | 1 |
| George, S; Jauch, J; Poeckel, D; Tausch, L; Werz, O | 1 |
| Collino, M; Dianzani, C; Fantozzi, R; Gallicchio, M; Menicagli, R; Samaritani, S; Signore, G | 1 |
| Desaulniers, P; Gilbert, C; Marois, S; Naccache, PH; Paré, G; Popa-Nita, O | 1 |
| Chen, LW; Hsu, CM; Huang, HL; Lee, IT; Lu, PJ | 1 |
| Aomatsu, K; Arakawa, T; Fujita, H; Hato, F; Kamata, N; Kato, T; Kitagawa, S; Oshitani, N; Tamura, T | 1 |
| Eckert, RE; Jones, SL | 1 |
| Fraser, JF; Fung, YL; Tung, JP; Wood, P | 1 |
| Berry, KA; Henson, PM; Murphy, RC | 1 |
| Crystal, GJ; Eom, W; Hu, G; Kim, SJ; Saad, MM | 1 |
| Lückhoff, A; Pantaler, E | 1 |
| Chen, J; Tan, Z; Xu, Y; Zhu, M; Zhu, X | 1 |
| Ahluwalia, J; Salmon, MD | 1 |
| Dobson, GP; Granfeldt, A; Jiang, R; Shi, W; Vinten-Johansen, J | 1 |
| Corris, PA; De Soyza, A; Gertig, H; Hester, KL; Macfarlane, JG; Ruchaud-Sparagano, MH; Simpson, AJ | 1 |
| Degawa-Yamauchi, M; Kanegasaki, S; Kuribayashi, F; Tsuchiya, T; Yamauchi, A | 1 |
| Blair, IA; Hergott, CB; Mesaros, C; Naidu, NA; Roche, AM; Weiser, JN | 1 |
| Gripentrog, J; Jesaitis, AJ; Voyich, JM | 1 |
5 review(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and n-formylmethionine leucyl-phenylalanine
| Article | Year |
|---|---|
Molecular mechanisms of leukocyte activation by chemoattractants.
Topics: Animals; Chemotactic Factors; GTP-Binding Proteins; Humans; Leukocytes; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor | 1991 |
The inhibiting effect of cetirizine 2 HC1 on eosinophil migration and its link to H1 blockade.
Topics: Cetirizine; Chemotaxis, Leukocyte; Eosinophils; Histamine H1 Antagonists; Humans; Hydroxyzine; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Receptors, Histamine H1; Skin | 1991 |
Neutrophil-dependent mediation of microvascular permeability.
Topics: Animals; Aspartic Acid Endopeptidases; Biological Transport; Capillary Permeability; Complement C5; Complement C5a; Cytoplasmic Granules; Endopeptidases; Endothelium; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen; Peptide Hydrolases; Platelet Activating Factor | 1986 |
Impaired activation of phospholipase D in polycythaemia vera-implications for the pathogenesis of the disease?
Topics: Enzyme Activation; Humans; Inositol 1,4,5-Trisphosphate; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidative Stress; Phospholipase D; Platelet Activating Factor; Polycythemia Vera; Tetradecanoylphorbol Acetate | 1995 |
The role of basophils in allergic disease.
Topics: Asthma; Basophils; Bronchoalveolar Lavage Fluid; Calcium; Cell Degranulation; Chymases; Complement C5a; Cytokines; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine; Histamine Release; Humans; Hypersensitivity; Interleukin-3; Interleukin-5; N-Formylmethionine Leucyl-Phenylalanine; Nasal Lavage Fluid; Phorbol Esters; Platelet Activating Factor; Prostaglandin D2; Receptors, IgE; Serine Endopeptidases; Skin; Tetradecanoylphorbol Acetate; Thapsigargin; Tryptases | 1996 |
5 trial(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and n-formylmethionine leucyl-phenylalanine
| Article | Year |
|---|---|
Effect of terfenadine on neutrophil and eosinophil chemotactic activities after inhalation of platelet-activating factor in vivo and on neutrophil chemotaxis in vitro.
Topics: Administration, Inhalation; Adult; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Eosinophils; Female; Humans; In Vitro Techniques; Leukocyte Count; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Terfenadine | 1992 |
The effect of eicosapentaenoic acid consumption on human neutrophil chemiluminescence.
Topics: Adult; Dietary Fats; Double-Blind Method; Eicosapentaenoic Acid; Female; Humans; Kinetics; Luminescent Measurements; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Olive Oil; Plant Oils; Platelet Activating Factor; Time Factors | 1991 |
Pharmacokinetics and pharmacodynamics of neutrophil-associated ciprofloxacin in humans.
Topics: Adult; Aged; Analysis of Variance; Ciprofloxacin; Female; Half-Life; Humans; Luminescent Measurements; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Time Factors | 1995 |
Long-term effect of nonsteroidal anti-inflammatory drugs on the production of cytokines and other inflammatory mediators by blood cells of patients with osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Diclofenac; Dinoprostone; Double-Blind Method; Female; Humans; Interleukin-1; Interleukin-6; Knee Joint; Leukotriene B4; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Osteoarthritis; Platelet Activating Factor; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 1994 |
Postinjury suppression of human neutrophil cytokine production results from the stabilization of inhibitory kappaB.
Topics: Adult; Cytokines; DNA-Binding Proteins; Humans; I-kappa B Proteins; In Vitro Techniques; Interleukin 1 Receptor Antagonist Protein; Interleukin-8; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Postoperative Complications; Sialoglycoproteins; Tumor Necrosis Factor-alpha; Wounds, Nonpenetrating; Wounds, Penetrating | 1999 |
467 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and n-formylmethionine leucyl-phenylalanine
| Article | Year |
|---|---|
Platelet-activating factor primes human eosinophil generation of superoxide.
Topics: Adult; Calcium; Eosinophils; Humans; Leukocyte Count; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Superoxides | 1992 |
The mechanism of internalization of platelet-activating factor in activated human neutrophils. Enhanced transbilayer movement across the plasma membrane.
Topics: Biological Transport; Cell Membrane; Cells, Cultured; Endocytosis; Humans; Lipid Bilayers; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Phospholipids; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1992 |
Neutrophil chemotactic factors promote leukocytosis. A common mechanism for cellular recruitment from bone marrow.
Topics: Animals; Bone Marrow Cells; Cells, Cultured; Chemotactic Factors; Complement C5a; Dactinomycin; Interleukin-8; Leukocytosis; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Pyrazoles; Rabbits; Receptors, Formyl Peptide; Receptors, Immunologic | 1992 |
C-reactive protein inhibits intracellular calcium mobilization and superoxide production by guinea pig alveolar macrophages.
Topics: Animals; C-Reactive Protein; Calcium; Dose-Response Relationship, Drug; Female; Guinea Pigs; Macrophages, Alveolar; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Superoxides; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Selective eosinophil leukocyte recruitment by transendothelial migration and not by leukocyte-endothelial cell adhesion.
Topics: Amitrole; Cell Adhesion; Cell Movement; Cytokines; Endothelium, Vascular; Eosinophils; Humans; Hypersensitivity; In Vitro Techniques; Interleukin-1; Leukotriene B4; Lipopolysaccharides; Microscopy, Electron; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peroxidases; Platelet Activating Factor; Tumor Necrosis Factor-alpha | 1992 |
Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects.
Topics: Asthma; Chemotaxis, Leukocyte; Eosinophilia; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Interleukin-5; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rhinitis | 1992 |
Differential responsiveness of human neutrophils to the autocrine actions of 1-O-alkyl-homologs and 1-acyl analogs of platelet-activating factor.
Topics: Acylation; Alkylation; Chemotaxis, Leukocyte; Humans; In Vitro Techniques; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Structure-Activity Relationship; Superoxides | 1992 |
Formation of LTB4 by fMLP-stimulated alveolar macrophages accounts for eosinophil migration in vitro.
Topics: Animals; Benzeneacetamides; Cell Movement; Chemotactic Factors, Eosinophil; Diterpenes; Eosinophils; Ginkgolides; Guinea Pigs; Hydroxamic Acids; Indomethacin; Lactones; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages, Alveolar; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Sensitivity and Specificity; Stimulation, Chemical | 1992 |
Degree of neutrophil chemotaxis is dependent upon the chemoattractant and barrier.
Topics: Animals; Cell Line; Cells, Cultured; Chemotactic Factors; Chemotaxis, Leukocyte; Dogs; Endothelium, Vascular; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor | 1992 |
Differential effects of platelet-activating factor on superoxide anion production in human eosinophils and neutrophils.
Topics: Eosinophils; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxides; Zymosan | 1992 |
Superoxide production by human eosinophils can be inhibited in an agonist-selective manner.
Topics: Alkaloids; Androstadienes; Carbazoles; Eosinophils; Humans; Immunoglobulin G; Indole Alkaloids; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Protein Kinase C; Sphingosine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin; Zymosan | 1992 |
Effects of nedocromil sodium and WEB 2086 on chemoattractant-stimulated neutrophil migration through cellular and noncellular barriers.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Azepines; Cells, Cultured; Chemotaxis, Leukocyte; Endothelium, Vascular; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Nedocromil; Neutrophils; Platelet Activating Factor; Quinolones; Triazoles | 1992 |
Arachidonic acid release and platelet-activating factor formation by staurosporine in human neutrophils challenged with n-formyl peptide.
Topics: Alkaloids; Arachidonic Acid; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Protein Kinase C; Staurosporine | 1992 |
Subcellular localization and release of human neutrophil gelatinase, confirming the existence of separate gelatinase-containing granules.
Topics: Cytoplasmic Granules; Enzyme-Linked Immunosorbent Assay; Gelatinases; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Lactoferrin; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Pepsin A; Platelet Activating Factor; Protein Binding; Subcellular Fractions; Vitamin B 12; Zymosan | 1992 |
Regulation of platelet-activating-factor receptors and the desensitization response in polymorphonuclear neutrophils.
Topics: Calcium; Cycloheximide; Dactinomycin; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serum Albumin, Bovine | 1992 |
Regulation of leukotriene biosynthesis in human polymorphonuclear leukocytes.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcium; Chromatography, High Pressure Liquid; Egtazic Acid; Fluorescent Dyes; Fura-2; Humans; Ionomycin; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor | 1992 |
Activation of NADPH oxidase and phospholipase D in permeabilized human neutrophils. Correlation between oxidase activation and phosphatidic acid production.
Topics: Adenine Nucleotides; Adult; Analysis of Variance; Arachidonic Acid; Bacterial Toxins; Calcium; Cell Membrane Permeability; Diglycerides; Enzyme Activation; Ethanol; Guanosine 5'-O-(3-Thiotriphosphate); Hemolysin Proteins; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phosphatidic Acids; Phospholipase D; Platelet Activating Factor; Reference Values; Second Messenger Systems; Staphylococcus aureus; Superoxides | 1992 |
Guinea-pig treatment with pertussis toxin suppresses macrophage-dependent bronchoconstriction by fMLP and fails to inhibit the effects of PAF.
Topics: Adenosine Diphosphate Ribose; Animals; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cholera Toxin; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Guinea Pigs; Lung; Macrophages, Alveolar; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Superoxides; Thromboxane B2; Trachea; Virulence Factors, Bordetella | 1992 |
Enhancement by staurosporine of platelet-activating factor formation in N-formyl peptide-challenged human neutrophils is mediated by intracellular platelet-activating factor binding sites.
Topics: Alkaloids; Azepines; Binding Sites; Calcium; Drug Synergism; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staurosporine; Triazoles | 1992 |
Modulation of arachidonic acid metabolism and cyclic AMP content of human alveolar macrophages.
Topics: Adult; Aged; Aged, 80 and over; Arachidonic Acid; Calcimycin; Cell Count; Cells, Cultured; Cyclic AMP; Cyclooxygenase Inhibitors; Female; Humans; Lipoxygenase Inhibitors; Macrophage Activation; Macrophages, Alveolar; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic | 1992 |
Phalloidin prevents leukocyte emigration induced by proinflammatory stimuli in rat mesentery.
Topics: Animals; Antigens, CD; CD11 Antigens; CD18 Antigens; Chemotaxis, Leukocyte; Flow Cytometry; Leukocytes; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Phalloidine; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Splanchnic Circulation; Venules | 1992 |
PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats.
Topics: Animals; Azepines; Endothelins; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Lung; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pulmonary Circulation; Rats; Triazoles; Vasoconstriction | 1992 |
Thrombin promotes actin polymerization in U937 human monocyte-macrophage cells. Analysis of the signalling mechanisms mediating actin polymerization.
Topics: Actins; Alkaloids; Calcium; Cations, Divalent; Cell Line; Chemotaxis, Leukocyte; GTP-Binding Proteins; Humans; Indoles; Ionomycin; Macrophages; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Polymers; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Virulence Factors, Bordetella | 1992 |
Adenosine inhibits divalent cation influx across human neutrophil plasma membrane via surface adenosine A2 receptors.
Topics: Adenosine; Adenosine Deaminase; Adult; Calcium; Cations, Divalent; Cell Membrane; Humans; In Vitro Techniques; Ion Transport; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Receptors, Purinergic; Theophylline | 1992 |
Enhanced production of platelet-activating factor in stimulated rat leukocytes pretreated with triacsin C, A novel acyl-coA synthetase inhibitor.
Topics: Acylation; Animals; Calcimycin; Coenzyme A Ligases; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Repressor Proteins; Saccharomyces cerevisiae Proteins; Triazenes | 1992 |
The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils.
Topics: Adult; Asthma; Azepines; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Eosinophils; Female; Humans; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; SRS-A; Triazoles | 1992 |
Control of plasma-membrane Ca2+ entry by the intracellular Ca2+ stores. Kinetic evidence for a short-lived mediator.
Topics: Calcium; Cell Compartmentation; Cell Membrane; Cell Membrane Permeability; Econazole; Humans; In Vitro Techniques; Ionomycin; Kinetics; Manganese; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Temperature | 1992 |
Aggregation of human polymorphonuclear leukocytes by endothelin: role of platelet-activating factor.
Topics: Azepines; Calcium; Cell Aggregation; Centrifugation, Density Gradient; Cytosol; Diterpenes; Dose-Response Relationship, Drug; Endothelins; Ginkgolides; Humans; Lactones; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Triazoles | 1992 |
Ligand dependent release of activated neutrophil collagenase--a role for surface bound IgG in the degradation of articular collagens.
Topics: Arthritis, Rheumatoid; Cartilage, Articular; Collagenases; Humans; Immunoglobulin G; Ligands; Matrix Metalloproteinase 8; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Receptors, Antigen, B-Cell; Synovial Fluid; Tetradecanoylphorbol Acetate; Zymosan | 1992 |
Characterization of platelet-activating factor synthesized by normal and granulocyte-macrophage colony-stimulating factor-primed human eosinophils.
Topics: Calcimycin; Cells, Cultured; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor | 1992 |
Platelet-activating factor as an intercellular signal in neutrophil-dependent platelet activation.
Topics: Amino Acid Sequence; Animals; Azepines; Blood Platelets; Cells, Cultured; Fibrinogen; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Signal Transduction; Thromboxane A2; Triazoles | 1992 |
A sensitive and specific radioimmunoassay for platelet-activating factor.
Topics: Animals; Calcimycin; Cross Reactions; Immunoglobulin G; Kinetics; Microchemistry; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipids; Platelet Activating Factor; Rabbits; Radioimmunoassay | 1992 |
Ligand-operated synthesis of 4-series and 5-series leukotrienes in human neutrophils: critical dependence on exogenous free fatty acid supply.
Topics: Calcimycin; Chromatography, High Pressure Liquid; Fatty Acids, Nonesterified; Humans; Hydrolysis; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Leukotrienes; Ligands; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidation-Reduction; Platelet Activating Factor | 1992 |
WEB 2086 inhibits neutrophil dependent increases in coronary resistance in blood perfused rabbit heart.
Topics: Animals; Azepines; Disease Models, Animal; Myocardial Reperfusion Injury; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rabbits; Triazoles; Vascular Resistance | 1992 |
IL-8 production by human polymorphonuclear leukocytes. The chemoattractant formyl-methionyl-leucyl-phenylalanine induces the gene expression and release of IL-8 through a pertussis toxin-sensitive pathway.
Topics: Cells, Cultured; Complement C5a; Cytochalasin B; Gene Expression; Humans; Interleukin-8; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Platelet Activating Factor; RNA, Messenger; Virulence Factors, Bordetella | 1992 |
Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system.
Topics: Animals; Brain; Cell Movement; Chemotactic Factors; Female; Interleukin-1; Interleukin-8; Leukocytes; Male; Mice; Mice, Inbred BALB C; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Tumor Necrosis Factor-alpha | 1992 |
The effect of serine and thiol protease inhibitors on the chemiluminescence of human neutrophils in investigations in vitro.
Topics: Calcimycin; Cysteine Proteinase Inhibitors; Humans; In Vitro Techniques; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Respiratory Burst; Serine Proteinase Inhibitors; Tetradecanoylphorbol Acetate; Tosylarginine Methyl Ester; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Tyrosine; Zymosan | 1992 |
Receptor-operated activation of polymorphonuclear leukocytes: different effects of NAP-1/IL-8 and fMet-Leu-Phe or C5a.
Topics: Arachidonate 5-Lipoxygenase; Complement C5a; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-8; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Receptors, Formyl Peptide; Receptors, Immunologic; Superoxides | 1991 |
Modulation and induction of eosinophil chemotaxis by granulocyte-macrophage colony-stimulating factor and interleukin-3.
Topics: Chemotaxis, Leukocyte; Complement C5a; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Interleukin-8; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor | 1991 |
Dibutyryl cyclic AMP induces formyl peptide receptor expression and chemotactic responses in a human eosinophilic cell line, EoL-1.
Topics: Actins; Bucladesine; Butyrates; Butyric Acid; Calcium; Cell Differentiation; Cell Division; Cell Line; Chemotaxis, Leukocyte; Complement C5a; Eosinophils; Humans; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Polymers; Receptors, Formyl Peptide; Receptors, Immunologic; Time Factors | 1991 |
Roles of Ca2+ in human neutrophil responses to receptor agonists.
Topics: Calcium; Cell Degranulation; Glucuronidase; Humans; In Vitro Techniques; Leukotriene B4; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Leukotriene B4; Signal Transduction; Superoxides; Temperature; Time Factors | 1991 |
Thrombin-activated platelets promote leukotriene B4 synthesis in polymorphonuclear leucocytes stimulated by physiological agonists.
Topics: Arachidonate 12-Lipoxygenase; Arachidonic Acid; Blood Platelets; Humans; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Activation; Thrombin | 1991 |
Suppression of cytoskeletal rearrangement in activated human neutrophils by botulinum C2 toxin. Impact on cellular signal transduction.
Topics: Actins; Aminoquinolines; Botulinum Toxins; Calcium; Cytoskeleton; Diglycerides; Fluorescent Dyes; Humans; Inositol Phosphates; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositols; Platelet Activating Factor; Polymers; Signal Transduction; Superoxides | 1991 |
Inhibition of cytoskeletal rearrangement by botulinum C2 toxin amplifies ligand-evoked lipid mediator generation in human neutrophils.
Topics: Arachidonate 5-Lipoxygenase; Botulinum Toxins; Chemotactic Factors; Chemotaxis, Leukocyte; Cytoskeleton; Eicosanoids; Humans; Hydrolysis; Hydroxyeicosatetraenoic Acids; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Phosphatidylinositols; Platelet Activating Factor | 1991 |
Tumor necrosis factor-alpha primes pulmonary hemodynamic response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine.
Topics: Animals; Antioxidants; Drug Synergism; Guinea Pigs; Hemodynamics; Lung; N-Formylmethionine Leucyl-Phenylalanine; Organ Size; Peroxidase; Platelet Activating Factor; Pulmonary Circulation; Tetradecanoylphorbol Acetate; Thromboxane A2; Tumor Necrosis Factor-alpha; Vascular Resistance | 1991 |
Tumor necrosis factor-alpha regulates expression of receptors for formyl-methionyl-leucyl-phenylalanine, leukotriene B4, and platelet-activating factor. Dissociation from priming in human polymorphonuclear neutrophils.
Topics: Cell Degranulation; Humans; In Vitro Techniques; Leukotriene B4; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Leukotriene B4; Tumor Necrosis Factor-alpha; Up-Regulation | 1991 |
Absence of FMLP receptors on rat macrophages.
Topics: Animals; Ascitic Fluid; Calcium; In Vitro Techniques; Macrophages; Macrophages, Alveolar; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Protein Binding; Rats; Receptors, Formyl Peptide; Receptors, Immunologic; Superoxides | 1991 |
Differential effects of propranolol on responses to receptor-dependent and receptor-independent stimuli in human neutrophils.
Topics: Calcium; Humans; In Vitro Techniques; Ionomycin; Isomerism; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipase D; Platelet Activating Factor; Propranolol; Respiratory Burst; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
PAF-mediated platelet adhesion to endothelial cells induced by FMLP-stimulated leukocytes.
Topics: Azepines; Endothelium, Vascular; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Adhesiveness; Triazoles; Umbilical Veins | 1991 |
Antiplatelet, antineutrophil and vasodilating properties of 13,14-dihydro-PGE1 (PGE0)--an in vivo metabolite of PGE1 in man.
Topics: Alprostadil; Animals; Blood Platelets; Glucuronidase; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rabbits; Superoxides; Vasodilation | 1991 |
Changes in inositol 1,4,5-trisphosphate mass in agonist-stimulated human neutrophils.
Topics: Calcium Channels; Cholera Toxin; Cytochalasin B; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Platelet Activating Factor; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Respiratory Burst; Stimulation, Chemical; Virulence Factors, Bordetella | 1991 |
Transcellular metabolism of arachidonic acid in platelets and polymorphonuclear leukocytes activated by physiological agonists: enhancement of leukotriene B4 synthesis.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Blood Platelets; Humans; In Vitro Techniques; Kinetics; Leukotriene B4; Models, Biological; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Activation; Thrombin | 1991 |
Platelet-activating factor may participate in signal transduction processes in rabbit leukocytes.
Topics: Animals; Arachidonic Acid; Azepines; Blood Platelets; Calcimycin; Chloroquine; Female; Kinetics; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Pyridinium Compounds; Rabbits; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Triazoles | 1991 |
Thrombin-mediated release of lipids from pulmonary artery endothelial cells promotes neutrophil adherence.
Topics: Amino Acids; Animals; Antibodies, Monoclonal; CD18 Antigens; Cell Adhesion; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; Endothelium, Vascular; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Pulmonary Artery; Receptors, Leukocyte-Adhesion; Sheep; Thrombin | 1991 |
Synergistic effect of thromboxane A2 and N-formylmethionylleucylphenylalanine on platelet-activating factor synthesis in human polymorphonuclear neutrophils.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetyl-CoA C-Acetyltransferase; Binding Sites; Bridged Bicyclo Compounds; Drug Synergism; Fatty Acids, Monounsaturated; Humans; Kinetics; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Thromboxane A2 | 1991 |
The effects of picumast on human eosinophil and neutrophil activation.
Topics: Animals; Cell Adhesion; Complement C3b; Coumarins; Cytokines; Eosinophils; Flow Cytometry; Histamine H1 Antagonists; Humans; Immunoglobulin A; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rosette Formation; Schistosoma; Up-Regulation | 1991 |
Platelet-activating factor induces mediator release by human basophils primed with IL-3, granulocyte-macrophage colony-stimulating factor, or IL-5.
Topics: Basophils; Complement C3a; Complement C5a; Dose-Response Relationship, Drug; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine Release; Humans; In Vitro Techniques; Interleukin-3; Interleukin-5; Interleukin-8; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Secretory Rate; SRS-A; Time Factors | 1991 |
Eosinophil activation on biologic surfaces. Production of O2- in response to physiologic soluble stimuli is differentially modulated by extracellular matrix components and endothelial cells.
Topics: Endothelium, Vascular; Eosinophils; Extracellular Matrix; Humans; In Vitro Techniques; Inflammation; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Substance P; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1991 |
Site of anti-inflammatory action of dexamethasone in rabbit skin.
Topics: Animals; Bradykinin; Dactinomycin; Dermatitis, Contact; Dexamethasone; Dinoprostone; Female; Histamine; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Protein Biosynthesis; Rabbits; RNA; Skin; Zymosan | 1991 |
The effects of cytokines, platelet activating factor, and arachidonate metabolites on C3b receptor (CR1, CD35) expression and phagocytosis by neutrophils.
Topics: Antigens, CD; Arachidonic Acids; Complement C3b; Cytokines; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-1; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Platelet Activating Factor; Receptors, Complement; Receptors, Complement 3b; Recombinant Proteins; Tumor Necrosis Factor-alpha; Up-Regulation | 1990 |
Release of newly synthesized platelet-activating factor (PAF) from human polymorphonuclear leukocytes under in vivo conditions. Contribution of PAF-releasing factor in serum.
Topics: Calcimycin; Cytokines; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor | 1992 |
Role of platelet activating factor in the adhesion process of polymorphonuclear neutrophils to endothelial cells.
Topics: Angiotensin II; Calcimycin; Cell Adhesion; Endothelium, Vascular; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Thrombin | 1991 |
Determination of platelet-activating factor by a chemiluminescence method and its application to stimulated guinea pig neutrophils.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Guinea Pigs; Indicators and Reagents; Luminescent Measurements; Luminol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipids; Platelet Activating Factor | 1991 |
Intracellular Ca2+ concentration and H2O2 production in mouse peritoneal macrophages are stimulated by platelet activating factor.
Topics: Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Egtazic Acid; Hydrogen Peroxide; Kinetics; Macrophages; Male; Mice; Mice, Inbred Strains; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Spectrometry, Fluorescence | 1991 |
Role of platelet-activating factor in aggregation of leukocytes and platelets in cerebral ischemia.
Topics: Blood Platelets; Brain Ischemia; Edetic Acid; Female; Humans; In Vitro Techniques; Kinetics; Leukocytes; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Aggregation; Reference Values | 1991 |
Platelet activating factor-induced pulmonary accumulation of 111Indium-oxine labelled neutrophils in anesthetized guinea pigs.
Topics: Analysis of Variance; Anesthesia, General; Animals; Guinea Pigs; In Vitro Techniques; Indium Radioisotopes; Kinetics; Lung; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Organometallic Compounds; Oxyquinoline; Platelet Activating Factor; Radioisotope Dilution Technique; Tetradecanoylphorbol Acetate | 1991 |
Tumor necrosis factor-alpha priming of phospholipase A2 activation in human neutrophils. An alternative mechanism of priming.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Cytochalasin B; Diglycerides; Enzyme Activation; Humans; Leukotriene B4; Membrane Lipids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Platelet Activating Factor; Tumor Necrosis Factor-alpha | 1991 |
Granulocyte-macrophage colony-stimulating factor is a stimulant of platelet-activating factor and superoxide anion generation by human neutrophils.
Topics: Anions; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Platelet Activating Factor; Superoxides; Virulence Factors, Bordetella | 1991 |
Regulation of the superoxide-forming NADPH oxidase of human neutrophils is not altered in essential hypertension.
Topics: Adult; Female; Humans; Hypertension; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Platelet Activating Factor; Signal Transduction; Superoxides | 1991 |
Superoxide responses to formyl-methionyl-leucyl-phenylalanine in primed neutrophils. Role of intracellular and extracellular calcium.
Topics: Calcium; Cytoplasm; Extracellular Space; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Ionomycin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
Phospholipase D activation by platelet-activating factor, leukotriene B4, and formyl-methionyl-leucyl-phenylalanine in rabbit neutrophils. Phospholipase D activation is involved in enzyme release.
Topics: Animals; Cell Degranulation; Diglycerides; Enzyme Activation; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Phospholipase D; Platelet Activating Factor; Rabbits | 1991 |
Differential actions of diacyl- and alkylacylglycerols in priming phospholipase A2, 5-lipoxygenase and acetyltransferase activation in human neutrophils.
Topics: Acetyltransferases; Adult; Arachidonate 5-Lipoxygenase; Calcimycin; Chromatography, Thin Layer; Diglycerides; Enzyme Activation; Humans; In Vitro Techniques; Kinetics; Lipids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Platelet Activating Factor; Structure-Activity Relationship | 1991 |
A product of activated human granulocytes stimulates prostaglandin E2 synthesis in human amnion cells.
Topics: Amnion; Cells, Cultured; Chorioamnionitis; Cytochalasin B; Dinoprostone; Epidermal Growth Factor; Female; Free Radical Scavengers; Granulocytes; Hot Temperature; Humans; Indomethacin; Labor, Obstetric; N-Formylmethionine Leucyl-Phenylalanine; Obstetric Labor, Premature; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Pregnancy; Protein Synthesis Inhibitors; Stimulation, Chemical | 1991 |
Time-dependent synergistic interactions between the vasodilator neuropeptide, calcitonin gene-related peptide (CGRP) and mediators of inflammation.
Topics: Animals; Calcitonin Gene-Related Peptide; Complement C5a; Drug Synergism; Epoprostenol; In Vitro Techniques; Indium Radioisotopes; Inflammation; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rabbits; Time Factors; Zymosan | 1991 |
Interferon-gamma enhances PAF-acether production by stimulated human polymorphonuclear leucocytes.
Topics: Antigen-Antibody Complex; Cells, Cultured; Humans; Interferon-gamma; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1991 |
Agonist-induced Ca2+ influx in human neutrophils is secondary to the emptying of intracellular calcium stores.
Topics: Calcium; Egtazic Acid; Fura-2; Humans; In Vitro Techniques; Ionomycin; Kinetics; Manganese; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor | 1991 |
Membrane surface antigen expression on neutrophils: a reappraisal of the use of surface markers for neutrophil activation.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Surface; Cell Separation; Centrifugation, Density Gradient; Cytochalasin B; Cytochrome b Group; Egtazic Acid; Humans; Microscopy, Immunoelectron; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Platelet Activating Factor | 1991 |
IL-3 and IL-5 prime normal human eosinophils to produce leukotriene C4 in response to soluble agonists.
Topics: Complement C5a; Eosinophils; Humans; In Vitro Techniques; Interleukin-3; Interleukin-5; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; SRS-A; Time Factors | 1991 |
Variations in chemotaxis and chemokinesis of neutrophils of different densities from patients with allergic rhinitis.
Topics: Cell Movement; Chemotaxis, Leukocyte; Humans; Leukocyte Count; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 1991 |
Differential inhibition by nedocromil sodium of superoxide generation elicited by platelet activating factor in human neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Nedocromil; Neutrophils; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Quinolones; Superoxides | 1990 |
Novel interactions between second messengers in rat basophilic leukaemia (RBL-1) cells.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Cyclic AMP; Enzyme Activation; Inositol Phosphates; Leukemia, Basophilic, Acute; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Second Messenger Systems; SRS-A; Tumor Cells, Cultured; Type C Phospholipases | 1990 |
Production of superoxide anion and hydrogen peroxide by human neutrophilic granulocytes during chemotactic migration towards f-Met-Leu-Phe, C5a, leukotriene B4, monocyte-derived chemotaxin/IL-8 and platelet-activating factor.
Topics: Chemokine CCL2; Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5a; Humans; Hydrogen Peroxide; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxides | 1990 |
Priming of neutrophil oxidative responses by platelet-activating factor.
Topics: Adult; Cytochalasin B; Drug Synergism; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Endothelial cell platelet-activating factor primes neutrophil responses: amplification of endothelial activation by neutrophil products.
Topics: Calcium; Cells, Cultured; Endothelium, Vascular; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxides | 1990 |
Rapid adhesive responses of endothelial cells and of neutrophils induced by leukotriene B4 are mediated by leucocytic adhesion protein CD18.
Topics: Antibodies, Monoclonal; CD18 Antigens; Cell Adhesion; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Lipoxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Plastics; Platelet Activating Factor; Receptors, Leukocyte-Adhesion; Thrombin | 1990 |
Neutrophil erythrotoxicity induced by phorbol myristate acetate: mechanisms involved in neutrophil activation.
Topics: Antigen-Antibody Complex; Calcimycin; Catalase; Cell Adhesion; Cell Survival; Chemotaxis; Dose-Response Relationship, Drug; Erythrocytes; Humans; Immunity, Cellular; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Platelet Activating Factor; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Two mechanisms for IgG Fc-receptor-mediated phagocytosis by human neutrophils.
Topics: Calcium; Humans; Immunoglobulin G; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Receptors, Fc | 1991 |
Lipopolysaccharide from Escherichia coli reduces antigen-induced bronchoconstriction in actively sensitized guinea pigs.
Topics: Animals; Antigens; Aspirin; Bronchoconstriction; Cell Degranulation; Endotoxins; Escherichia coli; Guinea Pigs; Hemodynamics; Histamine; Hypersensitivity; Leukopenia; Lipopolysaccharides; Mast Cells; Microscopy, Electron; N-Formylmethionine Leucyl-Phenylalanine; Ovalbumin; Platelet Activating Factor; Pyrilamine; Thromboxane B2 | 1991 |
Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils.
Topics: Alkaloids; Calcium; Complement C5a; Eosinophils; Exocytosis; Humans; Interleukin-8; N-Formylmethionine Leucyl-Phenylalanine; Peroxidases; Pertussis Toxin; Platelet Activating Factor; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Virulence Factors, Bordetella | 1991 |
Possible role for platelet-activating factor in neutrophil infiltration in allergic inflammation in rats.
Topics: Animals; Benzoquinones; Furans; Hypersensitivity; Immunization; Inflammation; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains | 1990 |
Density distribution and density conversion of neutrophils in allergic subjects.
Topics: Asthma; Cell Separation; Centrifugation, Density Gradient; Chemotaxis, Leukocyte; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hypersensitivity; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor | 1990 |
Platelet-activating factor-induced activation and cytoskeletal change in cultured eosinophils.
Topics: Actins; Cell Movement; Cells, Cultured; Cytoskeleton; Eosinophils; Humans; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor | 1990 |
Mechanism of N-formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-induced arachidonic acid release in guinea pig alveolar macrophages: involvement of a GTP-binding protein and role of protein kinase A and protein kinase C.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Down-Regulation; GTP-Binding Proteins; Guinea Pigs; Isoquinolines; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Pulmonary Alveoli; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1990 |
Production of 15-hydroxyeicosatetraenoic acid by purified human eosinophils and neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Separation; Complement C5a; Eosinophils; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor | 1990 |
Macrophage activation reduces mobilization of arachidonic acid by guinea-pig and rat peritoneal macrophages in vitro.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Calcimycin; Epoprostenol; Guinea Pigs; Macrophage Activation; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Peritoneal Cavity; Platelet Activating Factor; Rats; Rats, Inbred Strains; Zymosan | 1990 |
Thromboxane release by lymphokine-differentiated U937 human monocytic cells: response to platelet-activating factor (PAF) and chemotactic peptide (FMLP) but not to low affinity IGE-receptor (Fc epsilon RII/CD23) occupation.
Topics: Antibodies, Anti-Idiotypic; Antigens, Differentiation, B-Lymphocyte; Calcimycin; Drug Synergism; Humans; Immunoglobulin E; Interferon-gamma; Interleukin-4; Leukemia, Monocytic, Acute; Lymphokines; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Protein Binding; Receptors, Fc; Receptors, IgE; Tetradecanoylphorbol Acetate; Thromboxane B2; Tumor Cells, Cultured | 1990 |
Inhibition of platelet function by polymorphonuclear leukocytes.
Topics: Adenosine Diphosphate; beta-Thromboglobulin; Blood Platelets; Calcium; Collagen; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Thrombin | 1990 |
The adhesiveness of monocytic U937 cells is stimulated by pro-inflammatory agents and inhibited by adenosine 3':5'-cyclic monophosphate.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Alprostadil; Bucladesine; Calcitriol; Cell Adhesion; Cell Differentiation; Cell Line; Cyclic AMP; Diglycerides; Humans; Kinetics; Leukotriene B4; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Tretinoin | 1990 |
Ligand-dependent release of active neutrophil collagenase.
Topics: Arthritis, Rheumatoid; Cartilage, Articular; Humans; Immunoglobulin G; In Vitro Techniques; Ligands; Microbial Collagenase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Radioimmunoassay; Zymosan | 1990 |
Development of specific functionally active receptors for platelet-activating factor in HL-60 cells following granulocytic differentiation.
Topics: Acetylglucosaminidase; Binding, Competitive; Cell Differentiation; Cytochalasin B; Dimethyl Sulfoxide; Granulocytes; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tumor Cells, Cultured | 1990 |
Platelet activation by polymorphonuclear leukocytes exposed to chemotactic agents.
Topics: Blood Platelets; Calcium; Cell Aggregation; Cytoplasm; Humans; Leukocyte Count; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Time Factors | 1990 |
GM-CSF: receptor structure and transmembrane signaling.
Topics: Cell Membrane; Colony-Stimulating Factors; Cross-Linking Reagents; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Platelet Activating Factor; Receptors, Cell Surface; Receptors, Colony-Stimulating Factor; Sepharose; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Platelet-activating factor may act as a second messenger in the release of icosanoids and superoxide anions from leukocytes and endothelial cells.
Topics: Animals; Aorta; Bradykinin; Calcimycin; Cattle; Cells, Cultured; Eicosanoids; Endothelium, Vascular; Endotoxins; Epoprostenol; Guinea Pigs; In Vitro Techniques; Kinetics; Leukocytes; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide; Platelet Activating Factor; Second Messenger Systems; Superoxides | 1990 |
Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor.
Topics: Alkaloids; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Platelet Activating Factor; Protein Kinase C; Staurosporine; Superoxides | 1990 |
Platelet activating factor stimulates cyclo-oxygenase activity in guinea pig eosinophils. Concerted biosynthesis of thromboxane A2 and E-series prostaglandins.
Topics: Animals; Azepines; Calcimycin; Calcium; Complement C5a; Cyclooxygenase Inhibitors; Enzyme Activation; Eosinophils; Flurbiprofen; Guinea Pigs; Imidazoles; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Superoxides; Tetradecanoylphorbol Acetate; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Triazines; Triazoles | 1990 |
Leukotriene B4 potentiates colonic ulceration in the rat.
Topics: Administration, Rectal; Animals; Colitis; Drug Synergism; Ethanol; Leukotriene B4; Leukotrienes; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutropenia; Platelet Activating Factor; Rats; Rats, Inbred Strains; Ulcer | 1990 |
Superoxide responses of immune complex-stimulated rat alveolar macrophages. Intracellular calcium and priming.
Topics: Adenosine Triphosphate; Animals; Antigen-Antibody Complex; Calcimycin; Calcium; Complement C5a; Cytoplasm; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Pulmonary Alveoli; Rats; Superoxides | 1990 |
Cytotoxic enzyme release and oxygen centered radical formation in human neutrophils are selectively inhibited by E-type prostaglandins but not by PGI2.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cyclic AMP; Diterpenes; Epoprostenol; Free Radicals; Ginkgolides; Glucuronidase; Humans; In Vitro Techniques; Lactones; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Prostaglandins E; Superoxides | 1990 |
Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides.
Topics: Dose-Response Relationship, Drug; Drug Synergism; Exocytosis; GTP-Binding Proteins; Humans; In Vitro Techniques; Lipoproteins; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Structure-Activity Relationship; Superoxides; Tumor Necrosis Factor-alpha | 1990 |
Studies on the mechanism of platelet-activating factor production in GM-CSF primed neutrophils: involvement of protein synthesis and phospholipase A2 activation.
Topics: Arachidonate 5-Lipoxygenase; Arachidonate Lipoxygenases; Colony-Stimulating Factors; Cycloheximide; Dactinomycin; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; Leucine; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Uridine | 1990 |
Interactions between alkylglycerols and human neutrophil granulocytes.
Topics: Calcium; Cytochrome c Group; Glyceryl Ethers; Humans; Kinetics; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidation-Reduction; Phospholipid Ethers; Platelet Activating Factor | 1990 |
Calcium ionophore potentiates chemotactic peptide and platelet activating factor in stimulating thromboxane B2 and leukotriene B4 biosynthesis in human neutrophils.
Topics: Calcimycin; Drug Synergism; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Radioimmunoassay; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1990 |
Effect of a thromboxane A2 synthetase inhibitor (OKY-046.HCl) on airway hyperresponsiveness in guinea pigs.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Airway Resistance; Animals; Antigens; Aspirin; Bronchoalveolar Lavage Fluid; Guinea Pigs; Leukotriene E4; Methacrylates; N-Formylmethionine Leucyl-Phenylalanine; Phthalazines; Physostigmine; Platelet Activating Factor; Propranolol; Respiratory System; SRS-A; Thromboxane B2; Thromboxane-A Synthase | 1990 |
Noncytotoxic activation of neutrophils by eosinophil granule major basic protein. Effect on superoxide anion generation and lysosomal enzyme release.
Topics: Blood Proteins; Cell Degranulation; Cells, Cultured; Cytochalasin B; Eosinophil Granule Proteins; Eosinophils; Flow Cytometry; Glucuronidase; Humans; In Vitro Techniques; L-Lactate Dehydrogenase; Luminescent Measurements; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Ribonucleases; Superoxides | 1990 |
Priming of the human neutrophil respiratory burst by granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha involves regulation at a post-cell surface receptor level. Enhancement of the effect of agents which directly activate G
Topics: Complement C5a; Dose-Response Relationship, Drug; Granulocyte-Macrophage Colony-Stimulating Factor; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrogen Peroxide; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Receptors, Cell Surface; Signal Transduction; Sodium Fluoride; Superoxides; Time Factors; Tumor Necrosis Factor-alpha | 1990 |
Changes of fluorescence anisotropy in plasma membrane of human polymorphonuclear leukocytes during the respiratory burst phenomenon.
Topics: Adult; Cell Membrane; Diphenylhexatriene; Fluorescent Dyes; Humans; Kinetics; Luminescence; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Spectrometry, Fluorescence; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Selective inhibition of human neutrophil functional responsiveness by erbstatin, an inhibitor of tyrosine protein kinase.
Topics: Calcimycin; Chemotactic Factors; Humans; Hydroquinones; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Platelet Activating Factor; Protein-Tyrosine Kinases; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Priming effect of fibronectin on respiratory burst of human neutrophils induced by formyl peptides and platelet-activating factor.
Topics: Dose-Response Relationship, Drug; Enzyme Activation; Fibronectins; Free Radicals; Humans; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Platelet Activating Factor; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Stimulation and priming of protein kinase C translocation by a Ca2+ transient-independent mechanism. Studies in human neutrophils challenged with platelet-activating factor and other receptor agonists.
Topics: Calcium; Cell Compartmentation; Cell Membrane; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1990 |
IgG-dependent generation of platelet-activating factor by normal and low density human eosinophils.
Topics: Calcimycin; Cells, Cultured; Eosinophils; Humans; Immunoglobulin G; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Aggregation; SRS-A | 1990 |
Inhibition of neutrophil and eosinophil chemotactic responses to PAF by the PAF-antagonists WEB-2086, L-652,731, and SRI-63441.
Topics: Azepines; Chemotaxis; Complement C5; Eosinophils; Furans; Humans; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Quinolinium Compounds; Triazoles | 1990 |
Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness.
Topics: Cell Membrane; Estrenes; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; L-Lactate Dehydrogenase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Pyrrolidinones; Signal Transduction; Type C Phospholipases | 1990 |
Activation of human platelets by C5a-stimulated neutrophils: a role for cathepsin G.
Topics: Amino Acid Sequence; Aspirin; Azepines; Blood Platelets; Cathepsin G; Cathepsins; Complement C5a; Humans; In Vitro Techniques; Kinetics; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Pancreatic Elastase; Platelet Activating Factor; Platelet Activation; Protease Inhibitors; Recombinant Proteins; Serine Endopeptidases; Serotonin; Triazoles | 1990 |
Aggregation behaviour of blood granulocytes in patients with periodontal disease.
Topics: Adolescent; Adult; Aggressive Periodontitis; Cell Aggregation; Child; Female; Granulocytes; Humans; Male; N-Formylmethionine Leucyl-Phenylalanine; Periodontitis; Platelet Activating Factor | 1990 |
Effects of proinflammatory mediators on canine neutrophil chemotaxis and aggregation.
Topics: Analysis of Variance; Animals; Cell Aggregation; Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5a, des-Arginine; Dogs; Dose-Response Relationship, Drug; Inflammation; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor | 1990 |
Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Capillary Permeability; Complement C5; Complement C5a, des-Arginine; Dinoprostone; Drug Synergism; Edema; Histamine; Inflammation; Injections, Intradermal; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Nerve Tissue Proteins; Platelet Activating Factor; Prostaglandins E; Rabbits; Rats; Rats, Inbred Lew; Skin; Species Specificity; Substance P | 1985 |
New method for the measurement of eosinophil migration.
Topics: Caseins; Cells, Cultured; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Complement C5; Culture Media; Cytological Techniques; Eosinophils; Granulocytes; Humans; Leukotriene B4; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Staining and Labeling | 1987 |
Whole blood white cell aggregation: a novel technique.
Topics: Adult; Calcimycin; Cell Aggregation; Epoprostenol; Humans; Iloprost; In Vitro Techniques; Leukocytes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor | 1987 |
Platelet-activating factor primes neutrophil responses to agonists: role in promoting neutrophil-mediated endothelial damage.
Topics: Benzofurans; Cell Aggregation; Cell Survival; Diterpenes; Endothelium, Vascular; Fetal Hemoglobin; Furans; Ginkgolides; Hemoglobins, Abnormal; Humans; Inflammation; Lactones; Lignans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pancreatic Elastase; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Superoxides | 1988 |
Mass determination of receptor-mediated accumulation of phosphatidate and diglycerides in human neutrophils measured by Coomassie blue staining and densitometry.
Topics: Chromatography, Thin Layer; Densitometry; Diglycerides; Enzyme Activation; Glycerides; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Phospholipase D; Platelet Activating Factor; Protein Kinase C; Rosaniline Dyes; Staining and Labeling | 1989 |
Arachidonic acid release in rabbit neutrophils.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1989 |
Effects of human GM-CSF on neutrophil degranulation in vitro.
Topics: Calcimycin; Carrier Proteins; Colony-Stimulating Factors; Cytochalasin B; Cytoplasmic Granules; Exocytosis; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Secretory Rate; Transcobalamins; Vitamin B 12 | 1989 |
Vascular responses to leukocyte products in atherosclerotic primates.
Topics: Animals; Arteries; Arteriosclerosis; Dinoprostone; Epoprostenol; Hemodynamics; Leukocyte Count; Leukocytes; Lipids; Macaca fascicularis; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; SRS-A; Vasoconstrictor Agents | 1989 |
Calcium is necessary but not sufficient for the platelet-activating factor release in human neutrophils stimulated by physiological stimuli. Role of G-proteins.
Topics: Colony-Stimulating Factors; Egtazic Acid; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; GTP-Binding Proteins; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Second Messenger Systems; Zymosan | 1989 |
Phospholipid remodeling in human neutrophils. Parallel activation of a deacylation/reacylation cycle and platelet-activating factor synthesis.
Topics: Acylation; Calcimycin; Fatty Acids, Nonesterified; Glycerol; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oleic Acid; Oleic Acids; Phosphatidylcholines; Phospholipids; Platelet Activating Factor | 1989 |
Acetyltransferase activity and production of platelet-activating factor by human neutrophils activated with various stimuli.
Topics: Acetyltransferases; Calcimycin; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1989 |
Inhibition of human eosinophil chemotaxis and of the IgE-dependent stimulation of human blood platelets by cetirizine.
Topics: Blood Platelets; Cetirizine; Chemotaxis, Leukocyte; Chlorpheniramine; Cytotoxicity, Immunologic; Eosinophils; Humans; Hydroxyzine; Hypersensitivity; Immunoglobulin E; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor | 1989 |
Use of manganese to discriminate between calcium influx and mobilization from internal stores in stimulated human neutrophils.
Topics: Benzofurans; Calcium; Fura-2; Humans; Leukotriene B4; Manganese; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nickel; Platelet Activating Factor | 1989 |
Evidence for the role of platelet-activating factor in immune complex vasculitis in the rat.
Topics: Animals; Capillary Permeability; Furans; Hydroxides; Hydroxyl Radical; Immune Complex Diseases; Lymphocyte Activation; Microscopy, Electron; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Platelet Activating Factor; Rats; Vasculitis | 1989 |
Relaxant effect of N-formyl-methionyl-leucyl-phenylalanine on rabbit vascular strips.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Animals; Complement C5; Complement C5a; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rabbits; Vasodilation | 1989 |
Formation and release of nitric oxide from human neutrophils and HL-60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B4.
Topics: Bucladesine; Calcitriol; Canavanine; Cell Line; Humans; In Vitro Techniques; Kinetics; Leukemia, Promyelocytic, Acute; Leukotriene B4; Luminescence; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide; Platelet Activating Factor | 1989 |
Effects of C-reactive protein on human neutrophil granulocytes challenged with N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor.
Topics: C-Reactive Protein; Cell Membrane; Cytoplasmic Granules; Dose-Response Relationship, Drug; Humans; Kinetics; Lysophosphatidylcholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxides | 1989 |
Platelet-activating factor production in human neutrophils by sequential stimulation with granulocyte-macrophage colony-stimulating factor and the chemotactic factors C5A or formyl-methionyl-leucyl-phenylalanine.
Topics: Adult; Colony-Stimulating Factors; Complement C5; Complement C5a; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Recombinant Proteins; Superoxides; Time Factors | 1989 |
The effect of adherence on the generation of reactive oxygen species by human neutrophilic granulocytes.
Topics: Calcimycin; Cell Adhesion; Complement C5; Complement C5a; Granulocytes; Humans; Hydrogen Peroxide; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Superoxides; Tumor Necrosis Factor-alpha | 1989 |
Differential sensitivities of purified human eosinophils and neutrophils to defined chemotaxins.
Topics: Adult; Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5; Complement C5a; Eosinophils; Glucuronidase; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor | 1989 |
Synergism between chemotactic peptide and platelet-activating factor in stimulating thromboxane B2 and leukotriene B4 biosynthesis in human neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Humans; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Thromboxane B2 | 1989 |
Release of PAF-acether and eicosanoids from guinea-pig alveolar macrophages by FMLP: effect of cyclo-oxygenase and lipoxygenase inhibition.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate Lipoxygenases; Benzeneacetamides; Cyclooxygenase Inhibitors; Guinea Pigs; Hydroxamic Acids; In Vitro Techniques; Indomethacin; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pulmonary Alveoli; Pyrazoles; Radioimmunoassay; Thromboxane B2 | 1989 |
Phospholipase A2-mediated release of arachidonic acid in stimulated guinea pig alveolar macrophages: interaction with lipid mediators and cyclic AMP.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Calcimycin; Cyclic AMP; Dinoprostone; Guinea Pigs; Lipid Metabolism; Lipids; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Pulmonary Alveoli; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1989 |
Lack of effect of opioid peptides, morphine and naloxone on superoxide formation in human neutrophils and HL-60 leukemic cells.
Topics: Adenosine Triphosphate; Alprostadil; Biotransformation; Endorphins; Enkephalin, Methionine; Humans; In Vitro Techniques; Leukemia, Experimental; Morphine; N-Formylmethionine Leucyl-Phenylalanine; Naloxone; Neutrophils; Oxygen Consumption; Platelet Activating Factor; Superoxides; Tumor Cells, Cultured | 1989 |
Intracellular platelet-activating factor regulates eicosanoid generation in guinea-pig resident peritoneal macrophages.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Azepines; Calcimycin; Chromatography, High Pressure Liquid; Culture Media; Dinoprostone; Eicosanoids; Guinea Pigs; In Vitro Techniques; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Peritoneal Cavity; Platelet Activating Factor; Superoxides; Triazines; Triazoles | 1989 |
CV 6209 is a non-competitive antagonist of platelet-activating factor receptors on guinea-pig resident peritoneal macrophages.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Calcimycin; Epoprostenol; Guinea Pigs; In Vitro Techniques; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Pyridinium Compounds; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1989 |
The cell surface glycoprotein Mac-1 (CD11b/CD18) mediates neutrophil adhesion and modulates degranulation independently of its quantitative cell surface expression.
Topics: Antibodies, Monoclonal; Antigens, Differentiation; CD18 Antigens; Cell Adhesion; Cytoplasmic Granules; Humans; Macrophage-1 Antigen; Membrane Glycoproteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Second Messenger Systems; Signal Transduction; Temperature; Tumor Necrosis Factor-alpha | 1989 |
5-Hydroperoxyeicosatetraenoic acid (5-HPETE) enhances the synthesis of 1-O-alkyl-2-sn-acetyl-glycero-3-phosphocholine (PAF) in fMet-Leu-Phe-stimulated HL-60 cells: key role of diacylglycerol (DAG) in activation of protein kinase C (PKC).
Topics: Calcium; Cell Line; Diglycerides; Dimethyl Sulfoxide; Enzyme Activation; Glycerides; Humans; Inositol Phosphates; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Protein Kinase C | 1989 |
1,2-Diacylglycerol accumulation in human neutrophils does not correlate with respiratory burst activation.
Topics: Alkaloids; Diglycerides; Glycerides; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Phagocytosis; Platelet Activating Factor; Protein Kinase C; Staurosporine | 1989 |
The effects of PAF-acether and FMLP on eicosanoid production in guinea pig alveolar macrophages.
Topics: Animals; Arachidonic Acids; Guinea Pigs; In Vitro Techniques; Leukotrienes; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Prostaglandins; Pulmonary Alveoli | 1989 |
Immune system control of rat and rabbit colonic electrolyte transport. Role of prostaglandins and enteric nervous system.
Topics: Animals; Biological Transport; Colon; Electric Conductivity; Electrolytes; Free Radicals; Immune System; Immunoglobulin E; Indomethacin; Intestinal Mucosa; Male; Masoprocol; N-Formylmethionine Leucyl-Phenylalanine; Nervous System; Nervous System Physiological Phenomena; Platelet Activating Factor; Prostaglandins; Rabbits; Rats; Rats, Inbred Strains | 1989 |
Differential activation by fMet-Leu-Phe and phorbol ester of a plasma membrane phosphatidylcholine-specific phospholipase D in human neutrophil.
Topics: Cell Membrane; Cytochalasin B; Enzyme Activation; Humans; Hydrolysis; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylcholines; Phospholipase D; Phospholipases; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1989 |
Increased sensitivity of the chemoattractant-induced chemiluminescence in eosinophils isolated from atopic individuals.
Topics: Asthma; Dermatitis, Atopic; Eosinophils; Humans; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor | 1989 |
A new method to evaluate extravascular albumin and blood cell accumulation in the lung.
Topics: Acetylcholine; Animals; Blood Platelets; Blood Volume; Erythrocytes; Extracellular Space; Guinea Pigs; Indium Radioisotopes; Iodine Radioisotopes; Lung; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Pneumonia; Serum Albumin; Technetium; Tidal Volume | 1989 |
Oscillatory motion in human neutrophils responding to chemotactic stimuli.
Topics: Androstadienes; Chemotaxis, Leukocyte; Complement C5; Complement C5a; Humans; In Vitro Techniques; Leukotriene B4; Locomotion; Microscopy, Electron, Scanning; N-Formylmethionine Leucyl-Phenylalanine; Nephelometry and Turbidimetry; Neutrophils; Platelet Activating Factor | 1987 |
The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cytochalasin B; Diacylglycerol Kinase; Isoquinolines; Kinetics; Leupeptins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Phosphotransferases; Piperazines; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rabbits; Superoxides; Thiazoles | 1987 |
The priming of neutrophils by lipopolysaccharide for production of intracellular platelet-activating factor. Potential role in mediation of enhanced superoxide secretion.
Topics: Adjuvants, Immunologic; Body Fluids; Calcium; Cytosol; Dose-Response Relationship, Immunologic; Humans; Intracellular Fluid; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Diacylglycerols modulate human polymorphonuclear neutrophil responsiveness: effects on intracellular calcium mobilization, granule exocytosis, and superoxide anion production.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzofurans; Calcium; Cytochalasin B; Cytoplasmic Granules; Diglycerides; Dose-Response Relationship, Drug; Exocytosis; Fura-2; Glycerides; Humans; Isoquinolines; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Platelet Activating Factor; Superoxides | 1988 |
Platelet activating factor and leukotriene B4 induce hyperpolarization of human endothelial cells but depolarization of neutrophils.
Topics: Calcimycin; Cells, Cultured; Endothelium, Vascular; Humans; In Vitro Techniques; Leukotriene B4; Membrane Potentials; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1988 |
Activation of monocytes by interferon-gamma has no effect on the level or affinity of the nicotinamide adenine dinucleotide-phosphate oxidase and on agonist-dependent superoxide formation.
Topics: Calcium; Cells, Cultured; Cytochrome b Group; Humans; Hydrogen Peroxide; Interferon-gamma; Kinetics; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADP; NADPH Oxidases; Oxygen Consumption; Platelet Activating Factor; Protein Kinase C; Recombinant Proteins; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Leukotriene B4-induced homologous desensitization of calcium mobilization and phosphoinositide metabolism in U-937 cells.
Topics: Animals; Calcium; Cell Line; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidylinositols; Platelet Activating Factor; Receptors, Immunologic; Receptors, Leukotriene B4; SRS-A; Virulence Factors, Bordetella | 1988 |
Cytosolic calcium, oxygen consumption and the intracellular pH of stimulated neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cell Separation; Concanavalin A; Cytoplasm; Digitonin; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Platelet Activating Factor; Protons; Sodium; Tetradecanoylphorbol Acetate | 1988 |
Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes.
Topics: Alprostadil; Binding, Competitive; Furans; Humans; Kinetics; Leukocytes, Mononuclear; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1988 |
Pharmacological profile of 48740 R.P., a PAF-acether antagonist.
Topics: Animals; Blood Cell Count; Blood Platelets; Bronchodilator Agents; Guinea Pigs; Humans; In Vitro Techniques; Macrophages; Male; Muscle Contraction; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Perfusion; Platelet Activating Factor; Platelet Aggregation; Pulmonary Alveoli; Pyridines; Rabbits; Radioimmunoassay; Superoxides; Thiazoles; Thromboxane B2 | 1988 |
Agonist-induced calcium flux, phosphoinositide metabolism, aggregation and enzyme secretion in human neutrophils.
Topics: Adult; Calcium; Cell Aggregation; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositols; Platelet Activating Factor | 1988 |
SOD prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Depression, Chemical; Dinoprostone; Disease Models, Animal; Enterocolitis, Pseudomembranous; Leukotriene B4; Leukotrienes; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Prostaglandins; Rabbits; Superoxide Dismutase; Thromboxane B2 | 1988 |
Inhibition of eicosanoid and PAF formation by dexamethasone in rat inflammatory polymorphonuclear neutrophils may implicate lipocortin 's'.
Topics: Annexins; Calcimycin; Dexamethasone; Dinoprostone; Glycoproteins; Humans; Inflammation; Kinetics; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor | 1988 |
Effect of etizolam (Depas) on production of superoxide anion by platelet-activating factor and N-formyl-methionyl-leucyl-phenylalanine-stimulated guinea pig polymorphonuclear leukocytes.
Topics: Animals; Diazepam; Female; Guinea Pigs; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxides; Tranquilizing Agents | 1988 |
Function and stimulus-specific effects of phorbol 12-myristate 13-acetate on human polymorphonuclear neutrophils: autoregulatory role for protein kinase C in signal transduction.
Topics: Exocytosis; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pepstatins; Platelet Activating Factor; Protein Kinase C; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Effect of azelastine on the intracellular Ca2+ mobilization in guinea pig peritoneal macrophages.
Topics: Animals; Calcium; Cells, Cultured; Dinoprostone; Guinea Pigs; Histamine H1 Antagonists; Ketotifen; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Peritoneal Cavity; Phthalazines; Platelet Activating Factor; Prostaglandins E; Pyridazines | 1988 |
Dual mechanisms in priming of the chemoattractant-induced respiratory burst in human granulocytes. A Ca2+-dependent and a Ca2+-independent route.
Topics: Buffers; Calcium; Cytoplasm; Ethers; Granulocytes; Homeostasis; Humans; Ionomycin; Ionophores; N-Formylmethionine Leucyl-Phenylalanine; Oxygen Consumption; Platelet Activating Factor | 1989 |
The effect of intravascular neutrophil chemotactic factors on blood neutrophil and platelet kinetics.
Topics: Animals; Blood Platelets; Cell Survival; Chemotactic Factors; Chemotaxis, Leukocyte; Chromium Radioisotopes; Glycoproteins; Lung; Membrane Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pulmonary Circulation; Rabbits; Serotonin | 1986 |
Inhibition of eosinophil chemotaxis by a new antiallergic compound (cetirizine).
Topics: Cell Survival; Cells, Cultured; Cetirizine; Chemotaxis, Leukocyte; Chlorpheniramine; Eosinophils; Exocytosis; Humans; Hydroxyzine; In Vitro Techniques; L-Lactate Dehydrogenase; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor | 1988 |
Neutrophil degranulation: evidence pertaining to its mediation by the combined effects of leukotriene B4, platelet-activating factor, and 5-HETE.
Topics: Animals; Calcimycin; Complement C5; Complement C5a; Cytoplasmic Granules; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Lipids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rabbits | 1985 |
Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4.
Topics: Drug Synergism; Enzyme Activation; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen Consumption; Platelet Activating Factor; Superoxides; Time Factors | 1985 |
Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol ester.
Topics: Aminoquinolines; Animals; Bacterial Toxins; Calcium; Cytoplasmic Granules; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phorbols; Phosphatidic Acids; Phosphatidylinositol Phosphates; Phosphatidylinositols; Platelet Activating Factor; Rabbits; Tetradecanoylphorbol Acetate; Type C Phospholipases; Virulence Factors, Bordetella | 1985 |
Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig.
Topics: Aerosols; Animals; Bronchial Diseases; Constriction, Pathologic; Drug Tolerance; Guinea Pigs; Kinetics; Macrophage Activation; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pulmonary Alveoli; Superoxides | 1985 |
Exclusive leukotriene C4 synthesis by purified human eosinophils induced by opsonized zymosan.
Topics: Calcimycin; Eosinophils; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Opsonin Proteins; Platelet Activating Factor; SRS-A; Zymosan | 1985 |
Synergistic inhibition of complement induced granulocyte margination by BW755C and calcium channel blockers.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Agranulocytosis; Animals; Calcium; Calcium Channel Blockers; Cell Aggregation; Chemotactic Factors; Complement System Proteins; Female; Granulocytes; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pyrazoles; Rabbits; Verapamil | 1985 |
Modulation of neutrophil oxidative responses to soluble stimuli by platelet-activating factor.
Topics: Adult; Diglycerides; Fatty Acids; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen; Oxygen Consumption; Platelet Activating Factor; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1986 |
Human endothelial cells inhibit granulocyte aggregation in vitro.
Topics: Blood Coagulation Factors; Cell Aggregation; Cells, Cultured; Dinoprostone; Endothelium; Epoprostenol; Granulocytes; Humans; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Aggregation; Prostaglandins E; SRS-A | 1986 |
Leukocyte stimulation: receptor, membrane, and metabolic events. Introduction and summary.
Topics: Cell Membrane; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Platelet Activating Factor; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Leukotriene B4; Superoxides; Type C Phospholipases; Virulence Factors, Bordetella | 1986 |
Pertussis toxin as a probe of neutrophil activation.
Topics: Animals; Calcium; Cell Membrane; GTP-Binding Proteins; Guanosine Triphosphate; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphatidylinositols; Platelet Activating Factor; Protein Kinase C; Receptors, Formyl Peptide; Receptors, Immunologic; Sodium; Type C Phospholipases; Virulence Factors, Bordetella | 1986 |
Platelet-activating factor as a stimulus of exocytosis in human neutrophils.
Topics: Cytochalasin B; Dose-Response Relationship, Drug; Exocytosis; Humans; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxides; Time Factors | 1986 |
A comparative study on the effects of inhibitors of the lipoxygenase pathway on neutrophil function. Inhibitory effects on neutrophil function may not be attributed to inhibition of the lipoxygenase pathway.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Benzoquinones; Calcimycin; Chemotaxis, Leukocyte; Epoprostenol; Humans; Hydroxides; Hydroxyl Radical; Leukotriene B4; Lipoxygenase Inhibitors; Masoprocol; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Quinones; Tetradecanoylphorbol Acetate; Umbelliferones | 1986 |
Stimulus amplification by PAF and LTB4 in human neutrophils.
Topics: Calcium; Chemotaxis, Leukocyte; Diterpenes; Drug Synergism; Ginkgolides; Humans; In Vitro Techniques; Lactones; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Plant Extracts; Platelet Activating Factor | 1986 |
G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe.
Topics: Adenosine Diphosphate Ribose; Animals; Cell Membrane; Cell-Free System; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphoric Monoester Hydrolases; Platelet Activating Factor; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1987 |
Stimulated release of neutral proteinases elastase and cathepsin G from inflammatory rat polymorphonuclear leukocytes.
Topics: Animals; Calcimycin; Cathepsin G; Cathepsins; Cytoplasmic Granules; Dose-Response Relationship, Drug; Inflammation; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pancreatic Elastase; Peritoneal Cavity; Platelet Activating Factor; Rats; Rats, Inbred Strains; Serine Endopeptidases | 1987 |
Lack of correlation between calcium mobilization and respiratory burst activation induced by chemotactic factors in rabbit polymorphonuclear leukocytes.
Topics: Animals; Calcium; Chemotaxis, Leukocyte; Complement C5; Complement C5a; Kinetics; Leukotriene B4; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Platelet Activating Factor; Rabbits; Superoxides | 1987 |
Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether.
Topics: Animals; Cells, Cultured; Cytochalasin B; Diterpenes; Exocytosis; Ginkgolides; Glucuronidase; Lactones; Leukotriene B4; Male; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Plant Extracts; Platelet Activating Factor; Pyridines; Rats; Rats, Inbred Strains; Thiazoles | 1987 |
Signalling for increased cytoskeletal actin in neutrophils.
Topics: Actins; Animals; Calcimycin; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Osmolar Concentration; Pertussis Toxin; Platelet Activating Factor; Rabbits; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1987 |
Effect of group B streptococcal type-specific antigen on polymorphonuclear leukocyte function and polymorphonuclear leukocyte-endothelial cell interaction.
Topics: Antigens, Bacterial; Cell Adhesion; Cells, Cultured; Chemotaxis, Leukocyte; Complement System Proteins; Endothelium; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Streptococcus agalactiae; Zymosan | 1987 |
In vitro and in vivo effects of treatment by platelet-activating factor on N-formyl-met-leu-phe-mediated responses of polymorphonuclear leucocytes.
Topics: Animals; Granulocytes; Humans; Leukocyte Count; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rabbits; Superoxides | 1987 |
Influence of lysophospholipids and PAF on the oxidative burst of PMNL.
Topics: Acetophenones; Animals; Complement C5; Complement C5a; Female; Guinea Pigs; In Vitro Techniques; Luminescent Measurements; Lysophosphatidylcholines; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1987 |
The onset of the respiratory burst in human neutrophils. Real-time studies of H2O2 formation reveal a rapid agonist-induced transduction process.
Topics: Ethers; Humans; Hydrogen Peroxide; Ionomycin; Kinetics; Leukotriene B4; Luminescent Measurements; Mathematics; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen Consumption; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1987 |
Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids.
Topics: Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Dexamethasone; Humans; Immunoglobulin E; Lung; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Prostaglandin Antagonists; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins D; Prostaglandins F; SRS-A; Thromboxane B2 | 1986 |
Chemoattractant-induced activation of c-fos gene expression in human monocytes.
Topics: beta 2-Microglobulin; Cycloheximide; Dactinomycin; Gene Expression Regulation; GTP-Binding Proteins; Humans; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Protein Biosynthesis; Protein Kinase C; Proto-Oncogenes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transcriptional Activation; Virulence Factors, Bordetella | 1987 |
Rapid intracellular calcium changes in U937 monocyte cell line: transient increases in response to platelet-activating factor and chemotactic peptide but not interferon-gamma or lipopolysaccharide.
Topics: Adenosine Triphosphate; Calcium; Cell Line; Humans; Interferon-gamma; Ionophores; Lipopolysaccharides; Macrophage Activation; Macrophages; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor | 1987 |
1-Acyl-2-acetyl-sn-glycero-3-phosphocholine from stimulated human polymorphonuclear leukocytes.
Topics: Animals; Blood Platelets; Calcimycin; Chromatography, Thin Layer; Humans; Kinetics; Mass Spectrometry; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Rabbits | 1987 |
Platelet-activating factor both stimulates and "primes" human polymorphonuclear leukocyte actin filament assembly.
Topics: Actin Cytoskeleton; Actins; Calcimycin; Calcium; Cytoskeleton; Drug Synergism; Egtazic Acid; Humans; Masoprocol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Platelet Activating Factor; Quinolinium Compounds; Time Factors; Virulence Factors, Bordetella | 1987 |
Platelet-leukocyte interaction: activation of rabbit platelets by FMLP-stimulated neutrophils.
Topics: Acetylglucosaminidase; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Female; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Rabbits | 1987 |
Adherence of human basophils to cultured umbilical vein endothelial cells.
Topics: Basophils; Calcimycin; Cations, Divalent; Cell Adhesion; Cell Line; Complement C5; Complement C5a; Cycloheximide; Dactinomycin; Endothelium, Vascular; Glucocorticoids; Humans; Interleukin-1; Kinetics; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Temperature; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Umbilical Veins | 1988 |
Release of prostaglandin E2 and thromboxane B2 by mixed isolated human lung cells.
Topics: Bradykinin; Calcimycin; Cells, Cultured; Dinoprostone; Humans; Immunoenzyme Techniques; Lung; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Prostaglandins E; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1988 |
Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.
Topics: Adenosine Triphosphate; Calcium; Enzyme Activation; Ethanol; Granulocytes; Humans; Kinetics; Leukemia, Myeloid; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidic Acids; Phosphatidylethanolamines; Phospholipase D; Phospholipases; Phospholipids; Phosphorus Radioisotopes; Platelet Activating Factor; Tumor Cells, Cultured; Type C Phospholipases | 1988 |
PAF-acether and endotoxin display similar effects on rat mesenteric microvessels: inhibition by specific antagonists.
Topics: Animals; Azepines; Blood Pressure; Diterpenes; Endotoxins; Ginkgolides; Lactones; Male; Microcirculation; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rats; Rats, Inbred Strains; Splanchnic Circulation; Triazines; Triazoles | 1988 |
Enhancement of phorbol ester-induced protein kinase activity in human neutrophils by platelet-activating factor.
Topics: Calcium; Cytochalasin B; Enzyme Activation; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate | 1988 |
Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-O-alkyl-2-acyl diglycerides. Possible relation to effects on protein kinase C.
Topics: Cytosol; Diglycerides; Enzyme Activation; Glycerides; Humans; Hydrogen Peroxide; In Vitro Techniques; Indicators and Reagents; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Platelet Activating Factor; Protein Kinase C; Structure-Activity Relationship | 1988 |
Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion.
Topics: Animals; Calcium; Catalase; Cattle; Cell Adhesion; Cell Membrane Permeability; Endothelium, Vascular; Humans; Hydrogen Peroxide; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor | 1988 |
Intracellular calcium rise produced by platelet-activating factor is deactivated by fMet-Leu-Phe and this requires uninterrupted activation sequence: role of protein kinase C.
Topics: Animals; Benzofurans; Calcium; Fluorescent Dyes; Fura-2; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Platelet Activating Factor; Protein Kinase C; Rabbits; Spectrometry, Fluorescence; Virulence Factors, Bordetella | 1988 |
Stimulation of eosinophil adherence to human vascular endothelial cells in vitro by platelet-activating factor.
Topics: Antibodies, Monoclonal; Antigens, Differentiation; Antigens, Surface; Cell Adhesion; Cell Adhesion Molecules; Endothelium, Vascular; Eosinophils; Flow Cytometry; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor | 1988 |
An improved method for the isolation of eosinophilic granulocytes from peripheral blood of normal individuals.
Topics: Cell Separation; Centrifugation, Density Gradient; Chemotaxis, Leukocyte; Eosinophils; Humans; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Oxygen Consumption; Platelet Activating Factor; SRS-A; Time Factors | 1988 |
Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes.
Topics: Diglycerides; Enzyme Activation; Ethanol; Glycerophospholipids; Granulocytes; Humans; Kinetics; Leukemia, Myeloid; Lysophosphatidylcholines; N-Formylmethionine Leucyl-Phenylalanine; Oligopeptides; Phosphates; Phosphatidic Acids; Phospholipase D; Phospholipases; Phospholipid Ethers; Platelet Activating Factor; Tumor Cells, Cultured | 1988 |
Direct evidence for the existence of a neutrophil-derived platelet activator (neutrophilin).
Topics: Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Humans; Hydrazines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenylmethylsulfonyl Fluoride; Platelet Activating Factor; Platelet Aggregation | 1986 |
Age-dependent differential development of leukotactic and vasoactive responsiveness to acute inflammatory mediators.
Topics: Aging; Animals; Blood; Bradykinin; Capillary Permeability; Chemotaxis, Leukocyte; Dinoprostone; Female; Histamine; Inflammation; Kinetics; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Prostaglandins E; Rabbits; Zymosan | 1986 |
Polymorphonuclear leukocyte-dependent plasma leakage in the rabbit skin is enhanced or inhibited by prostacyclin, depending on the route of administration.
Topics: Alprostadil; Animals; Bradykinin; Complement C5; Complement C5a, des-Arginine; Drug Synergism; Edema; Epoprostenol; Infusions, Parenteral; Injections, Intradermal; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Plasma Volume; Platelet Activating Factor; Rabbits; Skin Diseases | 1986 |
A step sensitive to pertussis toxin and phorbol ester in human neutrophils regulates chemotaxis and capping but not phagocytosis.
Topics: Chemotaxis, Leukocyte; Concanavalin A; Fluorescein-5-isothiocyanate; Fluoresceins; Fluorescent Dyes; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phagocytosis; Phorbols; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1986 |
Platelet activating factor raises intracellular calcium ion concentration in macrophages.
Topics: Animals; Cadmium; Calcium; Collagen; Cytoplasm; In Vitro Techniques; Macrophages; Manganese; Mice; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Vasopressins | 1986 |
Platelet-activating factor (PAF-acether) induced leukotriene C4 formation and luminol dependent chemiluminescence by human eosinophils.
Topics: Eosinophils; Humans; In Vitro Techniques; Luminescent Measurements; Luminol; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pyridazines; SRS-A; Zymosan | 1986 |
Polymorphonuclear leukocyte-platelet interactions: acetylglyceryl ether phosphocholine-induced platelet activation under stimulation with chemotactic peptide.
Topics: Animals; Blood Platelets; Masoprocol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thiazoles | 1986 |
Evidence that platelet activating factor may mediate some acute inflammatory responses. Studies with the platelet-activating factor antagonist, CV3988.
Topics: Acute Disease; Animals; Blood Platelets; Capillary Permeability; Cell Movement; Inflammation; Leukocytes; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutropenia; Phospholipid Ethers; Platelet Activating Factor; Rabbits; Regional Blood Flow; Serum Albumin; Skin; Thiazoles; Thrombocytopenia | 1986 |
Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular albumin.
Topics: Calcium; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Serum Albumin; Tritium | 1985 |
Desensitization of acute inflammatory lesions to chemotaxins and endotoxin.
Topics: Acute Disease; Animals; Caseins; Chemotactic Factors; Desensitization, Immunologic; Dose-Response Relationship, Immunologic; Endotoxins; Female; Inflammation; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rabbits; Zymosan | 1984 |
Various authentic chemoattractants mediating leukocyte adherence inhibition.
Topics: Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Adhesion; Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5; Complement C5a, des-Arginine; Humans; Leukocyte Adherence Inhibition Test; Leukocytes; Leukotriene B4; Liver Neoplasms; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; SRS-A; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1984 |
Neutrophil-degranulating action of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid and 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. Comparison with other degranulating agents.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cattle; Chemotactic Factors; Cytochalasin B; Cytoplasmic Granules; Humans; In Vitro Techniques; Leukotriene B4; Lysophosphatidylcholines; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Rabbits; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1981 |
Evidence for 5, 12-dihydroxy-6,8,10,14-eicosatetraenoate as a mediator of human neutrophil aggregation.
Topics: Arachidonic Acids; Calcimycin; Cell Aggregation; Chemotaxis, Leukocyte; Complement C5; Complement C5a; Humans; Kinetics; Leukotriene B4; Lysophosphatidylcholines; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1981 |
Monocyte aggregation and superoxide anion release in response to formyl-methionyl-leucyl-phenylalanine (FMLP) and platelet-activating factor (PAF).
Topics: Calcium; Cell Aggregation; Cytochalasin B; Deoxyglucose; Humans; Iodoacetates; Iodoacetic Acid; Lysophosphatidylcholines; Magnesium; Methionine; Monocytes; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Oligopeptides; Oxygen; Platelet Activating Factor; Superoxides | 1982 |
Metabolic, membrane, and functional responses of human polymorphonuclear leukocytes to platelet-activating factor.
Topics: Cell Adhesion; Cell Aggregation; Cell Membrane; Chemotaxis, Leukocyte; Humans; Lysophosphatidylcholines; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Oxygen Consumption; Platelet Activating Factor; Platelet Aggregation; Superoxides | 1982 |
Stimulation of the human neutrophil superoxide anion-generating system with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3- phosphorylcholine.
Topics: Calcium; Cytochalasin B; Dose-Response Relationship, Drug; Egtazic Acid; Humans; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxides | 1984 |
Effects of an anion channel blocker, 4, 4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS), on human neutrophil function.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Cell Membrane; Cell Membrane Permeability; Cytochalasin B; Cytoplasmic Granules; Exocytosis; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Stilbenes; Superoxides | 1984 |
5-L-hydroxy-6,8,11,14-eicosatetraenoate potentiates the human neutrophil degranulating action of platelet-activating factor.
Topics: Arachidonic Acids; Calcimycin; Complement C5; Complement C5a; Drug Synergism; Glucuronidase; Humans; Hydroxyeicosatetraenoic Acids; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Time Factors | 1983 |
Increased biosynthesis of platelet-activating factor in activated human eosinophils.
Topics: Acetyltransferases; Calcimycin; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Eosinophils; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Phospholipases A; Platelet Activating Factor | 1984 |
Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular Ca2+.
Topics: Adult; Calcium; Edetic Acid; Egtazic Acid; Feedback; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor | 1984 |
Diacylglycerols enhance human neutrophil degranulation responses: relevancy to a multiple mediator hypothesis of cell function.
Topics: Animals; Calcimycin; Cytoplasmic Granules; Diglycerides; Glycerides; Humans; Kinetics; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rabbits; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1984 |
Kinetics of neutrophil accumulation in acute inflammatory lesions induced by chemotaxins and chemotaxinigens.
Topics: Acute Disease; Animals; Caseins; Chemotactic Factors; Concanavalin A; Dose-Response Relationship, Immunologic; Endotoxins; Female; Inflammation; Kinetics; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rabbits; Zymosan | 1984 |
Enhancement of human polymorphonuclear leukocyte adherence by the phospholipid mediator 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (AGEPC).
Topics: Adult; Cell Adhesion; Dose-Response Relationship, Drug; Humans; Indomethacin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Thromboxane A2 | 1983 |
Inducible binding of bioactive cathepsin G to the cell surface of neutrophils. A novel mechanism for mediating extracellular catalytic activity of cathepsin G.
Topics: Cathepsin G; Cathepsins; Cell Membrane; Enzyme Induction; Humans; Membrane Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Protein Binding; Serine Endopeptidases; Tumor Necrosis Factor-alpha | 1995 |
Zymosan-induced IL-8 release from human neutrophils involves activation via the CD11b/CD18 receptor and endogenous platelet-activating factor as an autocrine modulator.
Topics: Antibodies, Monoclonal; Calcimycin; CD18 Antigens; Humans; Integrins; Interleukin 1 Receptor Antagonist Protein; Interleukin-8; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Sialoglycoproteins; Tetrazoles; Tumor Necrosis Factor-alpha; Zymosan | 1994 |
Changes in subcellular localization and surface expression of L-selectin, alkaline phosphatase, and Mac-1 in human neutrophils during stimulation with inflammatory mediators.
Topics: Alkaline Phosphatase; Cell Adhesion Molecules; Cell Membrane; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Immunohistochemistry; L-Selectin; Macrophage-1 Antigen; Microscopy, Immunoelectron; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Subcellular Fractions; Tumor Necrosis Factor-alpha; Up-Regulation | 1994 |
Granulocyte and granulocyte-macrophage colony-stimulating factors exert differential effects on neutrophil platelet-activating factor generation and release.
Topics: Arachidonic Acid; Calcium; Cells, Cultured; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Recombinant Proteins; Respiratory Burst; Superoxides; Tumor Necrosis Factor-alpha | 1994 |
Strain-dependency of leukotriene C4 generation from isolated lungs of immunized mice.
Topics: Animals; Antibodies; Antigens; Arachidonic Acid; Histamine Release; Immunization; Leukotriene C4; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; N-Formylmethionine Leucyl-Phenylalanine; Perfusion; Platelet Activating Factor; Rats; Rats, Wistar; Species Specificity | 1994 |
Regulation of monocyte integrin expression by beta-family chemokines.
Topics: Calcium; CD18 Antigens; Cell Adhesion; Chemotactic Factors; Cytokines; Flow Cytometry; GTP-Binding Proteins; Humans; In Vitro Techniques; Integrins; Interleukin-1; Leukotriene B4; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Up-Regulation | 1994 |
Histamine release from human basophils induced by platelet activating factor: the role of extracellular calcium, interleukin-3, and granulocyte-macrophage colony-stimulating factor.
Topics: Antibodies, Anti-Idiotypic; Basophils; Buffers; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine Release; Humans; Immunoglobulin E; Interleukin-3; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Time Factors | 1995 |
In vitro effects of oxidized low density lipoprotein on CD11b/CD18 and L-selectin presentation on neutrophils and monocytes with relevance for the in vivo situation.
Topics: 1-Butanol; Adult; Animals; Butanols; CD18 Antigens; Cell Adhesion Molecules; Cells, Cultured; Cricetinae; Female; Flow Cytometry; Fluorescence Polarization; Humans; L-Selectin; Lipoproteins, LDL; Macrophage-1 Antigen; Male; Mesocricetus; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pentoxifylline; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1995 |
Activation of polymorphonuclear leukocytes reduces their adhesion to P-selectin and causes redistribution of ligands for P-selectin on their surfaces.
Topics: Animals; Binding Sites; Calcium; CD11 Antigens; CD18 Antigens; Cell Adhesion; CHO Cells; Cricetinae; Cytochalasin D; Humans; Interleukin-8; Ligands; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; P-Selectin; Platelet Activating Factor; Platelet Membrane Glycoproteins | 1995 |
L-selectin (CD62L) cross-linking signals neutrophil adhesive functions via the Mac-1 (CD11b/CD18) beta 2-integrin.
Topics: Adult; Antibodies, Monoclonal; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Chemotaxis, Leukocyte; Collagen; Endothelium, Vascular; Fibrinogen; Flow Cytometry; Humans; Immunoglobulin Fab Fragments; Integrins; L-Selectin; Macrophage-1 Antigen; Microspheres; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Protein Conformation; Receptor Aggregation; Serum Albumin; Signal Transduction | 1995 |
Induction of eosinophil cytokine generation by chemoattractants.
Topics: Actin Cytoskeleton; Chemotactic Factors; Complement C5a; Cytochalasin B; Enzyme Inhibitors; Eosinophils; GTP-Binding Proteins; Humans; In Vitro Techniques; Interleukin-8; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Signal Transduction; Virulence Factors, Bordetella | 1995 |
Effects of physiologic soluble agonists on leukotriene C4 production and degranulation by human eosinophils.
Topics: Blood Proteins; Cell Degranulation; Chemotactic Factors; Complement C5a; Eosinophil Granule Proteins; Eosinophils; Humans; In Vitro Techniques; Interleukin-3; Interleukin-5; Leukotriene C4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Ribonucleases; Tumor Necrosis Factor-alpha | 1995 |
GABA-mediated inhibition of the anaphylactic response in the guinea-pig trachea.
Topics: Anaphylaxis; Animals; beta-Alanine; Bronchial Hyperreactivity; Capsaicin; Drug Interactions; Epithelial Cells; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Histamine Release; Macrophage Activation; Macrophages, Alveolar; Male; Mast Cells; Muscle Contraction; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Nipecotic Acids; Ovalbumin; Platelet Activating Factor; Proline; Receptors, GABA; Tetrodotoxin; Trachea | 1995 |
CD66 family members are associated with tyrosine kinase activity in human neutrophils.
Topics: Antigens, CD; Antigens, Differentiation; Cell Adhesion Molecules; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Platelet Activating Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-hck; Signal Transduction; src-Family Kinases; Tetradecanoylphorbol Acetate | 1995 |
A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Humans; Lipids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Reproducibility of Results | 1995 |
Stimulation of platelet-activating factor synthesis in polymorphonuclear leukocytes from streptozotocin-induced diabetic rats.
Topics: Acetates; Acetyltransferases; Acyltransferases; Animals; Arachidonic Acid; Biological Assay; Diabetes Mellitus, Experimental; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Kinetics; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Rats, Wistar; Reference Values | 1995 |
Differential induction of stress proteins and functional effects of heat shock in human phagocytes.
Topics: Cadmium; Cadmium Compounds; Erythrocytes; Gene Expression Regulation; Hot Temperature; HSP70 Heat-Shock Proteins; Humans; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phagocytosis; Platelet Activating Factor; Respiratory Burst; Staphylococcus aureus; Sulfates; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1995 |
Postinjury neutrophil priming and activation: an early vulnerable window.
Topics: Adolescent; Adult; Female; Humans; Inflammation; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxides; Time Factors; Wounds and Injuries | 1995 |
The linoleic acid metabolite 13-HODE modulates degranulation of human polymorphonuclear leukocytes.
Topics: Antigens, CD; Antigens, Neoplasm; Cell Adhesion Molecules; Cell Degranulation; Cell Membrane; Cells, Cultured; Humans; Linoleic Acids; Macrophage-1 Antigen; Membrane Glycoproteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Up-Regulation | 1995 |
Leukotriene synthesis in calcium-depleted human neutrophils: arachidonic acid release correlates with calcium influx.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcium; Chromatography, High Pressure Liquid; Enzyme Activation; Humans; In Vitro Techniques; Kinetics; Leukotriene B4; Leukotrienes; Mass Spectrometry; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Platelet Activating Factor | 1995 |
Acute pro-inflammatory actions of endothelin-1 in the guinea-pig lung: involvement of ETA and ETB receptors.
Topics: Animals; Azepines; Blood Pressure; Bosentan; Bronchopulmonary Sequestration; Capillary Permeability; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Guinea Pigs; In Vitro Techniques; Indoles; Injections, Intravenous; Lung; Macrophages, Alveolar; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutropenia; Neutrophils; Peptide Fragments; Plasma Volume; Platelet Activating Factor; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
Biphasic Ca2+ responses in human basophils. Evidence that the initial transient elevation associated with the mobilization of intracellular calcium is an insufficient signal for degranulation.
Topics: Basophils; Calcium; Cell Degranulation; Cells, Cultured; Egtazic Acid; Histamine Release; Humans; Immunoglobulin E; Lanthanum; Manganese; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor | 1993 |
Release of platelet activation factor from activated neutrophils. Transglutaminase-dependent enhancement of transbilayer movement across the plasma membrane.
Topics: Cell Membrane; Cystamine; Erythrocyte Membrane; Humans; In Vitro Techniques; Ionomycin; Kinetics; Lipid Bilayers; Membrane Lipids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Sarcosine; Serum Albumin; Tetradecanoylphorbol Acetate; Time Factors; Transglutaminases | 1993 |
Calphostin C, a specific protein kinase C inhibitor, activates human neutrophils: effect on phospholipase A2 and aggregation.
Topics: Arachidonic Acid; Calcium; Cell Aggregation; Enzyme Activation; Fura-2; Humans; N-Formylmethionine Leucyl-Phenylalanine; Naphthalenes; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Polycyclic Compounds; Protein Kinase C | 1993 |
Activation of human neutrophils by tachykinins: effect on formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-stimulated superoxide anion production and antibody-dependent cell-mediated cytotoxicity.
Topics: Antibody-Dependent Cell Cytotoxicity; Cells, Cultured; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Substance P; Superoxides; Tachykinins | 1993 |
Selective regulation of expression of surface adhesion molecules Mac-1, L-selectin, and VLA-4 on human eosinophils and neutrophils.
Topics: Cell Adhesion; Cell Adhesion Molecules; Eosinophils; Humans; Interleukin-5; L-Selectin; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Receptors, Very Late Antigen | 1993 |
Inflammatory roles of P-selectin.
Topics: Antigens, CD; Calcium; CD11 Antigens; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cell Membrane; Cells, Cultured; Endothelium, Vascular; Humans; Inflammation; Microscopy, Electron, Scanning; Models, Biological; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; P-Selectin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thrombin; Umbilical Veins; Up-Regulation | 1993 |
The effects of the potent glucocorticoid budesonide on adhesion of eosinophils to human vascular endothelial cells and on endothelial expression of adhesion molecules.
Topics: Budesonide; Cell Adhesion; Cell Adhesion Molecules; E-Selectin; Endothelium, Vascular; Eosinophils; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pregnenediones; Vascular Cell Adhesion Molecule-1 | 1993 |
Superoxide generation by guinea-pig peritoneal macrophages is inhibited by rolipram, staurosporine and mepacrine in an agonist-dependent manner.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Macrophages, Peritoneal; Male; N-Formylmethionine Leucyl-Phenylalanine; Phospholipases A; Phospholipases A2; Phosphoric Diester Hydrolases; Platelet Activating Factor; Protein Kinase C; Pyrrolidinones; Quinacrine; Respiratory Burst; Rolipram; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1994 |
Interleukin-1-induced leukocyte extravasation across rat mesenteric microvessels is mediated by platelet-activating factor.
Topics: Animals; Azepines; Cell Adhesion; Chemotaxis, Leukocyte; Dihydropyridines; Edema; Imidazoles; Inflammation; Interleukin-1; Leukocytes; Male; Mesentery; Microcirculation; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Skin; Triazoles | 1995 |
Mechanisms for lipoxin A4 induced neutrophil dependent cytotoxicity for human endothelial cells.
Topics: Azepines; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Leukotriene B4; Lipoxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Triazoles; Umbilical Veins; Virulence Factors, Bordetella | 1995 |
Evidence for the predominant role of intracellular PAF binding sites in the regulation of phospholipase A2 in human neutrophils.
Topics: Alkaloids; Azepines; Humans; Indoles; Leukotriene Antagonists; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staurosporine; Triazoles | 1995 |
Chemoattractants induce rapid release of the interleukin 1 type II decoy receptor in human polymorphonuclear cells.
Topics: Amino Acid Sequence; Calcimycin; Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5a; Humans; In Vitro Techniques; Interleukin-1; Interleukin-8; Leukotriene B4; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Receptors, Interleukin-1; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1995 |
5-Oxo-eicosanoids are potent eosinophil chemotactic factors. Functional characterization and structural requirements.
Topics: Chemotactic Factors; Chemotaxis, Leukocyte; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Eicosanoic Acids; Eosinophilia; Eosinophils; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indicators and Reagents; Kinetics; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Structure-Activity Relationship | 1995 |
Comparative studies indicate that platelet-activating factor is a relatively weak eosinophilotactic mediator.
Topics: Adult; Cells, Cultured; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Endothelium, Vascular; Eosinophils; Epithelial Cells; Female; Humans; Leukotriene B4; Lung; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Umbilical Veins | 1995 |
Agonist-induced Ca2+ influx in human neutrophils is not mediated by production of inositol polyphosphates but by emptying of the intracellular Ca2+ stores.
Topics: Calcium; Humans; In Vitro Techniques; Inositol Phosphates; Intracellular Fluid; Ion Transport; Manganese; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Terpenes; Thapsigargin | 1994 |
Eosinophils isolated with two different methods show different characteristics of activation.
Topics: Antigens, CD; Cell Separation; Cells, Cultured; Chemotaxis, Leukocyte; Eosinophils; Flow Cytometry; Humans; Immunomagnetic Separation; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Receptors, IgG; Respiratory Burst; Zymosan | 1995 |
Comparison of neutrophil chemotactic factor release by human and rabbit alveolar macrophages in response to tannin exposure.
Topics: Animals; Arachidonic Acid; Calcimycin; Cells, Cultured; Chemotaxis, Leukocyte; Culture Media, Conditioned; Humans; Hydrolyzable Tannins; Interleukin-8; Lipoxygenase Inhibitors; Macrophages, Alveolar; Masoprocol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1995 |
Effects of platelet activating factor receptor antagonists on intracellular platelet activating factor function in neutrophils.
Topics: Animals; Azepines; Binding, Competitive; Calcium; Cell Count; Cell Degranulation; Chemotaxis, Leukocyte; Free Radical Scavengers; Inositol 1,4,5-Trisphosphate; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridines; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reference Standards; Signal Transduction; Structure-Activity Relationship; Superoxides; Thiazoles; Thiazolidines; Triazoles; Vitamin E | 1994 |
Effects of ZCR-2060 on allergic airway inflammation and cell activation in guinea-pigs.
Topics: Animals; Benzoates; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Eosinophils; Guinea Pigs; Inflammation; Leukotriene B4; Macrophages, Alveolar; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperidines; Platelet Activating Factor; Respiratory Hypersensitivity; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Modulation of leukocyte migration in mesenteric interstitium.
Topics: Animals; Antibodies, Monoclonal; CD18 Antigens; Cephalosporins; Chemotaxis, Leukocyte; Ischemia; Leukocytes; Leukotriene B4; Male; Microscopy, Video; N-Formylmethionine Leucyl-Phenylalanine; Pancreatic Elastase; Platelet Activating Factor; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reperfusion; Serpins; Serum Albumin; Splanchnic Circulation; Time Factors | 1994 |
Priming of the oxidative burst in human neutrophils by physiological agonists or cytochalasin B results from the recruitment of previously non-responsive cells.
Topics: Cells, Cultured; Cytochalasin B; Cytokines; Fluorides; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Respiratory Burst; Signal Transduction; Tetradecanoylphorbol Acetate | 1994 |
Determinants of neutrophil HOCl generation: ligand-dependent responses and the role of surface adhesion.
Topics: Cell Adhesion; Cell Membrane; Humans; Hydrogen Peroxide; Hypochlorous Acid; Immunoglobulin G; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Peroxidase; Platelet Activating Factor; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1994 |
Chemotactic peptide down-regulation of calcium mobilization induced by platelet-activating factor and by leukotriene B4 in human neutrophils is uncovered by protein phosphatase inhibitors.
Topics: Alkaloids; Calcium; Down-Regulation; Ethers, Cyclic; Humans; Indoles; Leukotriene B4; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Signal Transduction; Staurosporine | 1994 |
Human neutrophil degranulation responses to nucleotides.
Topics: Adenine Nucleotides; Adenosine; Arachidonic Acids; Cytoplasmic Granules; Diglycerides; Drug Synergism; Humans; In Vitro Techniques; Ionomycin; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Ribonucleotides; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 1994 |
Neutrophil polarisation in plasma differs to that induced by endogenous chemoattractants with regard to frequency of uropod formation and requirement for divalent cations.
Topics: Calcium; Cell Communication; Cell Movement; Chemotactic Factors; Complement C5a; Drug Synergism; Humans; Interleukin-8; Leukotriene B4; Magnesium; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor | 1994 |
Autocrine enhancement of leukotriene synthesis by endogenous leukotriene B4 and platelet-activating factor in human neutrophils.
Topics: Amino Acid Sequence; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Complement C5a; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukotriene B4; Leukotrienes; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Platelet Activating Factor; Recombinant Proteins; Signal Transduction; Virulence Factors, Bordetella | 1994 |
Kinetics of 5-lipoxygenase activation, arachidonic acid release, and leukotriene synthesis in human neutrophils: effects of granulocyte-macrophage colony-stimulating factor.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Ionomycin; Kinetics; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Time Factors | 1994 |
Effects of lipoxin A4 on chemotaxis and degranulation of human eosinophils stimulated by platelet-activating factor and N-formyl-L-methionyl-L-leucyl-L-phenylalanine.
Topics: Blood Proteins; Cell Degranulation; Chemotaxis, Leukocyte; Eosinophil Granule Proteins; Eosinophils; Humans; Hydroxyeicosatetraenoic Acids; Lipoxins; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Ribonucleases | 1994 |
Disparate signal transduction in neutrophil CD18 adhesion receptor expression versus superoxide generation.
Topics: Adult; Humans; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Platelet Activating Factor; Signal Transduction; Superoxides | 1994 |
Effects of PAF, FMLP and opsonized zymosan on the release of ECP, elastase and superoxide from human granulocytes.
Topics: Blood Proteins; Cell Degranulation; Chemotaxis, Leukocyte; Eosinophil Granule Proteins; Granulocytes; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Pancreatic Elastase; Platelet Activating Factor; Ribonucleases; Superoxides; Zymosan | 1994 |
A sensitive detection of neutrophil activation by fluorescence quenching of membrane inserted singlet oxygen probe.
Topics: Benzofurans; Biphenyl Compounds; Cell Membrane; Cyclohexane Monoterpenes; Hydroxyl Radical; Monoterpenes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Onium Compounds; Oxygen; Photochemistry; Platelet Activating Factor; Singlet Oxygen; Spectrometry, Fluorescence; Terpenes; Tetradecanoylphorbol Acetate | 1994 |
Eosinophils recruited to the lung by segmental antigen challenge show a reduced chemotactic response to leukotriene B4.
Topics: Allergens; Antigens, Plant; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Eosinophils; Humans; In Vitro Techniques; Leukotriene B4; Lung; N-Formylmethionine Leucyl-Phenylalanine; Plant Proteins; Platelet Activating Factor | 1994 |
Effect of terfenadine on human eosinophil and neutrophil chemotactic response and generation of superoxide.
Topics: Adult; Asthma; Calcimycin; Cell Degranulation; Cell Separation; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Eosinophils; Female; Humans; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rhinitis; Superoxides; Terfenadine | 1994 |
Characterization of the human neutrophil C1q receptor and functional effects of free ligand on activated neutrophils.
Topics: Antibodies; Blotting, Western; Carrier Proteins; Cell Differentiation; Cell Membrane; Complement C1q; Humans; Hyaluronan Receptors; In Vitro Techniques; Kinetics; Leukemia, Promyelocytic, Acute; Macrophage-1 Antigen; Membrane Glycoproteins; Mitochondrial Proteins; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Receptors, Complement; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 1994 |
13-HODE inhibits the intracellular calcium increase of activated human polymorphonuclear cells.
Topics: Amino Acid Sequence; Calcium; Humans; Intracellular Fluid; Leukotriene B4; Linoleic Acids; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Stimulation, Chemical | 1994 |
A novel syndrome of severe neutrophil dysfunction: unresponsiveness confined to chemotaxin-induced functions.
Topics: Actins; Antigens, CD; Calcimycin; Calcium; CD18 Antigens; CD4 Antigens; CD8 Antigens; Cell Adhesion; Cell Aggregation; Chemotaxis, Leukocyte; Cytochalasin B; Endothelium, Vascular; Female; Humans; Immunologic Deficiency Syndromes; In Vitro Techniques; Infant, Newborn; Kinetics; Leukocyte Count; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Platelet Activating Factor; Reference Values; Sepsis; Syndrome; T-Lymphocyte Subsets | 1993 |
Rapid induction of arachidonic acid release by monocyte chemotactic protein-1 and related chemokines. Role of Ca2+ influx, synergism with platelet-activating factor and significance for chemotaxis.
Topics: Arachidonic Acid; Calcimycin; Calcium; Cell Line; Chemokine CCL2; Chemotactic Factors; Chemotaxis, Leukocyte; Cytokines; Egtazic Acid; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Recombinant Proteins; Structure-Activity Relationship; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1994 |
Impaired surface expression of PAF receptors on human neutrophils is dependent upon cell activation.
Topics: Calcimycin; Calcium; Cell Aggregation; Cell Membrane; Dose-Response Relationship, Drug; Down-Regulation; Egtazic Acid; Humans; In Vitro Techniques; Kinetics; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetradecanoylphorbol Acetate | 1994 |
Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils.
Topics: Asthma; Blood Proteins; Calcimycin; Eosinophil Granule Proteins; Eosinophils; Humans; In Vitro Techniques; Leukotriene C4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pyridines; Pyrimidinones; Ribonucleases; Secretory Rate | 1994 |
C5a as a model for chemotactic factor-stimulated tyrosine phosphorylation in the human neutrophil.
Topics: Benzoquinones; Cell Line; Chemotactic Factors; Complement C5a; Humans; In Vitro Techniques; Interleukin-8; Lactams, Macrocyclic; Leukotriene B4; Models, Biological; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Platelet Activating Factor; Quinones; Receptor, Anaphylatoxin C5a; Receptors, Complement; Rifabutin; RNA, Messenger; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
W-7, a calmodulin antagonist, primes the stimulation of human neutrophil respiratory burst by formyl peptides and platelet-activating factor.
Topics: Calcimycin; Calmodulin; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Respiratory Burst; Sulfonamides; Superoxides | 1994 |
Characterization of two different forms of mitogen-activated protein kinase kinase induced in polymorphonuclear leukocytes following stimulation by N-formylmethionyl-leucyl-phenylalanine or granulocyte-macrophage colony-stimulating factor.
Topics: Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, Gel; Chromatography, Ion Exchange; Complement C5a; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunoblotting; Interleukin-8; Isoenzymes; Leukotriene B4; Mitogen-Activated Protein Kinase Kinases; Molecular Weight; Mutagenesis, Site-Directed; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptide Mapping; Phosphopeptides; Phosphoprotein Phosphatases; Platelet Activating Factor; Point Mutation; Protein Kinases; Protein Phosphatase 2; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1994 |
Priming for the synthesis of 5-lipoxygenase products in human blood ex vivo by human granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha.
Topics: Arachidonate 5-Lipoxygenase; Calcimycin; Complement C5a; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-8; Kinetics; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Recombinant Proteins; Tumor Necrosis Factor-alpha; Zymosan | 1994 |
Endotoxin infusion primes elicited neutrophils and Kupffer cells for platelet-activating factor-induced and tripeptide formyl-methionine-leucine-phenylalanine-induced basal free intracellular calcium concentration responses.
Topics: Animals; Calcium; Cell Separation; Endotoxins; Escherichia coli; Flow Cytometry; Kupffer Cells; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Prospective Studies; Random Allocation; Rats; Rats, Sprague-Dawley | 1993 |
Inhibitory effects of azelastine hydrochloride on Ca2+ influx, actin polymerization and release of eosinophil cationic protein of an eosinophilic leukaemia cell line EoL-1.
Topics: Actins; Blood Proteins; Bucladesine; Calcimycin; Calcium-Transporting ATPases; Cell Differentiation; Culture Media; Dose-Response Relationship, Drug; Eosinophil Granule Proteins; Eosinophils; Humans; Hypersensitivity; Immunoglobulin G; Inflammation; Leukemia, Eosinophilic, Acute; Leukemia, T-Cell; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Phthalazines; Platelet Activating Factor; Polymers; Ribonucleases; Tumor Cells, Cultured | 1993 |
Dissociation of platelet-activating factor production and arachidonate release by the endomembrane Ca(2+)-ATPase inhibitor thapsigargin. Evidence for the involvement of a Ca(2+)-dependent route of priming in the production of lipid mediators by human poly
Topics: Arachidonic Acid; Calcium; Calcium-Transporting ATPases; Cell Membrane; Glycerophospholipids; Humans; In Vitro Techniques; Ionomycin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Platelet Activating Factor; Terpenes; Thapsigargin | 1993 |
Hepoxilin A3 inhibits the rise in free intracellular calcium evoked by formyl-methionyl-leucyl-phenylalanine, platelet-activating factor and leukotriene B4.
Topics: 8,11,14-Eicosatrienoic Acid; Calcium; Calcium-Transporting ATPases; Humans; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Stereoisomerism; Terpenes; Thapsigargin | 1993 |
Regulation of human neutrophil aggregation: comparable latent times, activator sensitivities, and exponential decay in aggregability for FMLP, platelet-activating factor, and leukotriene B4.
Topics: Adult; Cell Aggregation; Dose-Response Relationship, Drug; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Inhibitory effects of formoterol on platelet-activating factor induced eosinophil chemotaxis and degranulation.
Topics: Adult; Albuterol; Asthma; Blood Proteins; Cell Degranulation; Chemotaxis, Leukocyte; Dose-Response Relationship, Immunologic; Eosinophil Granule Proteins; Eosinophils; Ethanolamines; Female; Formoterol Fumarate; Humans; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Propranolol; Ribonucleases | 1993 |
Leukotriene B4 and C4 production in isolated rat gastric mucosal cells.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Bucladesine; Calcimycin; Cell Separation; Colforsin; Diglycerides; Female; Gastric Mucosa; Histamine; In Vitro Techniques; Interleukin-1; Interleukin-2; Kinetics; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Pentagastrin; Phenothiazines; Platelet Activating Factor; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1993 |
Activation of neutrophil migration by dioctanoyl-sn-glycerol and fMet-Leu-Phe is controlled by different pathways.
Topics: Animals; Chemotaxis, Leukocyte; Diglycerides; Glyceryl Ethers; Guanosine 5'-O-(3-Thiotriphosphate); Macrophage Activation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rabbits; Thiazoles | 1993 |
Control of Ca2+ entry into HL60 and U937 human leukaemia cells by the filling state of the intracellular Ca2+ stores.
Topics: Antifungal Agents; Biological Transport; Calcium; Cell Differentiation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytosol; Dimethyl Sulfoxide; Econazole; Humans; Imidazoles; Ionomycin; Leukemia; Manganese; N-Formylmethionine Leucyl-Phenylalanine; Nickel; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, G-Protein-Coupled; Receptors, Immunologic; Tumor Cells, Cultured | 1993 |
Stimulation of human polymorphonuclear leukocytes by leukotriene B4 and platelet-activating factor: an ultrastructural and pharmacological study.
Topics: Acetylglucosaminidase; Adult; Cell Aggregation; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Ionomycin; Leukotriene B4; Lipoxygenase Inhibitors; Microscopy, Electron; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Quinolines | 1993 |
Migratory responses of ovine neutrophils to inflammatory mediators in vitro and in vivo.
Topics: Animals; Cell Movement; Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5a; Female; Interleukin-8; Leukotriene B4; Microscopy; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Sheep; Skin; Spectrometry, Gamma | 1993 |
Stimulatory and inhibitory guanine-nucleotide-binding regulatory protein involvement in stimulation of arachidonic-acid release by N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor from guinea-pig alveolar macrophages. Differential re
Topics: Adenosine Diphosphate Ribose; Animals; Arachidonic Acid; Cell Membrane Permeability; Cells, Cultured; Cholera Toxin; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; Guanine Nucleotides; Guinea Pigs; Macrophages, Alveolar; Magnesium; Male; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Receptors, Cell Surface; Virulence Factors, Bordetella | 1993 |
1,3-Dioctanoylglycerol modulates arachidonate mobilization in human neutrophils and its inhibition by PGBx: evidence of a protein-kinase-C-independent role for diacylglycerols in signal transduction.
Topics: Arachidonic Acid; Calcimycin; Diglycerides; Dose-Response Relationship, Drug; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Polymers; Prostaglandins B; Protein Kinase C; Signal Transduction; Superoxides | 1993 |
A new sensitive chemiluminescence probe, L-012, for measuring the production of superoxide anion by cells.
Topics: Complement C5a; Humans; Imidazoles; Indicators and Reagents; Interferon-gamma; Kinetics; Leukemia, Eosinophilic, Acute; Luminescent Measurements; Luminol; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pyrazines; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Transient inhibition by chemotactic peptide of a store-operated Ca2+ entry pathway in human neutrophils.
Topics: Biological Transport; Calcium; Calcium-Transporting ATPases; Cells, Cultured; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Terpenes; Thapsigargin | 1993 |
Mechanism and regulation of neutrophil priming by platelet-activating factor.
Topics: Adult; Amiloride; Azepines; Calcium; Chelating Agents; Diacylglycerol Kinase; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphotransferases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Pyrimidinones; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Tetradecanoylphorbol Acetate; Thiazoles; Triazoles; Type C Phospholipases; Virulence Factors, Bordetella | 1993 |
5-hydroxyicosatetraenoate stimulates neutrophils by a stereospecific, G protein-linked mechanism.
Topics: Calcium; Cells, Cultured; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxides; Tumor Necrosis Factor-alpha | 1993 |
Lipoxin A4 induces hyperadhesiveness in human endothelial cells for neutrophils.
Topics: Calcium; Cell Adhesion; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Interleukin-1; Leukotriene B4; Lipoxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Thrombin | 1993 |
Interleukin-8 primes human neutrophils for enhanced superoxide anion production.
Topics: Calcium; Dose-Response Relationship, Immunologic; Humans; Interleukin-8; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Recombinant Proteins; Superoxides | 1993 |
GM-CSF regulates human eosinophil responses to F-Met peptide and platelet activating factor.
Topics: Calcium; Cells, Cultured; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor | 1993 |
Eosinophil migration in atopic dermatitis. I: Increased migratory responses to N-formyl-methionyl-leucyl-phenylalanine, neutrophil-activating factor, platelet-activating factor, and platelet factor 4.
Topics: Adolescent; Adult; Cell Movement; Chemotaxis, Leukocyte; Complement C5a; Dermatitis, Atopic; Eosinophils; Female; Humans; Interleukin-5; Interleukin-8; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Factor 4 | 1993 |
Diminished actin polymerization by neutrophils from newborn infants.
Topics: Actins; Adult; Cytoskeleton; Fetal Blood; Humans; In Vitro Techniques; Infant, Newborn; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Polymers | 1993 |
Biosynthesis of platelet-activating factor (PAF) induced by chemotactic peptide is modulated at the lyso-PAF:acetyl-CoA acetyltransferase level by calcium transient and phosphatidic acid.
Topics: Acetyltransferases; Biological Transport; Calcium; Cells, Cultured; Cytochalasin B; Diglycerides; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Phospholipases A; Platelet Activating Factor; Propranolol | 1993 |
Effects of adenosine and its analogues on actin polymerization in human polymorphonuclear leucocytes.
Topics: Actins; Adenosine; Adenosine Deaminase; Biopolymers; Complement C5a; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pentostatin; Platelet Activating Factor; Theophylline | 1993 |
Pharmacological differentiation by pertussis toxin of the in vivo acute responses to fMLP and PAF in guinea-pig lungs.
Topics: Acetylcholine; Animals; Blood Platelets; Blood Volume; Bronchoconstriction; Capillary Permeability; Female; Guinea Pigs; Leukocytes; Leukopenia; Lung; Male; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Thrombocytopenia; Virulence Factors, Bordetella | 1993 |
Upregulation of formyl-peptide and interleukin-8-induced eosinophil chemotaxis in patients with allergic asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Chemotaxis, Leukocyte; Complement C5a; Eosinophils; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-8; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Up-Regulation | 1993 |
Differences in eosinophil and neutrophil chemotactic responses in sowda and generalized form of onchocerciasis.
Topics: Adolescent; Adult; Chemotaxis, Leukocyte; Eosinophils; Female; Humans; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Onchocerciasis; Platelet Activating Factor | 1995 |
Inhibition of the production of platelet activating factor and of leukotriene B4 in activated neutrophils by nimesulide due to an elevation of intracellular cyclic adenosine monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytochalasin B; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoquinolines; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphodiesterase Inhibitors; Platelet Activating Factor; Protein Kinase Inhibitors; Sulfonamides; Zymosan | 1995 |
Alkyl-PAF and acyl-PAF human neutrophil priming for enhanced fMLP- and rC5a-induced superoxide anion production.
Topics: Adrenergic beta-Antagonists; Amino Acid Sequence; Anions; Azepines; Complement C5a; Drug Synergism; Female; Humans; Male; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphatidylcholines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Recombinant Proteins; Superoxides; Triazoles | 1996 |
Role of cytokines, tyrosine kinase, and protein kinase C on production of superoxide and induction of scavenging enzymes in human leukocytes.
Topics: Adult; Bleomycin; Calcimycin; Catalase; Cytokines; Enzyme Induction; Female; Glutathione Peroxidase; Humans; Interferon-gamma; Interleukin-1; Lymphocytes; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Protein Kinase C; Protein-Tyrosine Kinases; Respiratory Burst; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1996 |
Rat eosinophils: isolation and characterization of superoxide production.
Topics: Animals; Calcimycin; Cell Separation; Cytochalasin B; Eosinophils; Humans; In Vitro Techniques; Kinetics; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rats; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1996 |
Microvascular mechanisms of histamine-induced potentiation of leukocyte adhesion evoked by chemoattractants.
Topics: Amino Acid Sequence; Animals; Azepines; Chemotactic Factors; Drug Synergism; Female; Histamine; Leukocytes; Leukotriene B4; Microcirculation; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rats; Rats, Wistar; Splanchnic Circulation; Triazoles | 1995 |
Omega-3 fatty acids suppress the enhanced production of 5-lipoxygenase products from polymorph neutrophil granulocytes in cystic fibrosis.
Topics: Adolescent; Adult; Arachidonate 5-Lipoxygenase; Arachidonic Acids; Catechols; Child; Child, Preschool; Cystic Fibrosis; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Female; Fish Oils; Humans; Leukotrienes; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; Platelet Activating Factor; Tyrphostins | 1995 |
Histamine releasability of basophils and skin mast cells in chronic urticaria.
Topics: Adult; Antibodies, Anti-Idiotypic; Basophils; Calcimycin; Cimetidine; Female; Histamine Release; Humans; Immunoglobulin E; Interleukin-3; Leukotriene C4; Male; Mast Cells; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Skin; Urticaria | 1996 |
Granulocytes from chronic myeloid leukemia (CML) patients show differential response to different chemoattractants.
Topics: Chemotactic Factors; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Reference Values | 1996 |
Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine.
Topics: Basophils; Binding, Competitive; Bryostatins; Chemokine CCL2; Chemokine CCL5; Complement C5a; Cyclosporine; Histamine Release; Humans; Interleukin-1; Interleukin-8; Kinetics; Lactones; Leukotriene C4; Macrolides; N-Formylmethionine Leucyl-Phenylalanine; Oligopeptides; Platelet Activating Factor; Protein Binding; Tetradecanoylphorbol Acetate | 1996 |
Leukotriene B4 and platelet activating factor production in permeabilized human neutrophils: role of cytosolic PLA2 in LTB4 and PAF generation.
Topics: Adenosine Triphosphate; Adult; Calcium; Cell Compartmentation; Cell Membrane Permeability; Coenzyme A; Cytosol; GTP-Binding Proteins; Humans; Inflammation Mediators; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor | 1996 |
Inhibitory effects of the new anti-platelet agent KBT-3022 and its metabolite on rabbit neutrophil function in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Calcium; Cell Adhesion; Cilostazol; Complement C3-C5 Convertases; Complement C5a; Cyclooxygenase Inhibitors; Indomethacin; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Structure-Activity Relationship; Superoxides; Tetradecanoylphorbol Acetate; Tetrazoles; Thiazoles; Ticlopidine | 1996 |
Modulation of human neutrophil chemotaxis by the endothelin-B receptor agonist sarafotoxin S6c.
Topics: Calcium; Chemotaxis, Leukocyte; Cytoplasm; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Humans; Interleukin-8; Leukotriene B4; Lymphocyte Activation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptide Fragments; Peptides, Cyclic; Platelet Activating Factor; Receptors, Endothelin; Vasoconstrictor Agents; Viper Venoms | 1996 |
Effects of interleukin (IL)-3 and IL-5 on human eosinophil degranulation induced by complement components C3a and C5a.
Topics: Blood Proteins; Cell Degranulation; Complement C3a; Complement C5a; Cytochalasin B; Dose-Response Relationship, Drug; Eosinophil Granule Proteins; Eosinophils; Humans; Interleukin-3; Interleukin-5; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Ribonucleases | 1996 |
Inhibition of eosinophil chemotaxis by chronic blockade of nitric oxide biosynthesis.
Topics: Animals; Bradykinin; Carrageenan; Chemotaxis, Leukocyte; Enzyme Inhibitors; Leukocyte Count; Lipopolysaccharides; Male; N-Formylmethionine Leucyl-Phenylalanine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Platelet Activating Factor; Pleura; Rats; Rats, Wistar | 1996 |
Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways.
Topics: Amino Acid Sequence; Calcium; Chemotactic Factors; Egtazic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Interleukin-8; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Priming differentially regulates neutrophil adhesion molecule expression/function.
Topics: Antigens, CD; Cell Adhesion; Humans; Integrin alphaXbeta2; L-Selectin; Lipopolysaccharides; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Receptors, Complement 3b; Respiratory Burst; Tumor Necrosis Factor-alpha | 1996 |
Comparison of PAF- and fMLP-induced [Ca2+]i transients in human polymorphonuclear leukocytes.
Topics: Blood Coagulation Factors; Calcium; Extracellular Space; Fluorescent Dyes; Fura-2; Humans; Intracellular Fluid; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Receptors, Cell Surface | 1996 |
Inhibition of leukotriene formation and IL-8 release by the paf-receptor antagonist SM-12502.
Topics: Aluminum; Basophils; Calcimycin; Calcium; Depression, Chemical; Gene Expression Regulation; GTP-Binding Proteins; Humans; Interleukin-8; Ionophores; Leukocytes, Mononuclear; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Sodium Fluoride; Thiazoles; Thiazolidines | 1996 |
Neutrophils from patients after burn injury express a deficiency of the oxidase components p47-phox and p67-phox.
Topics: Adult; Burns; Cell-Free System; Cytochrome b Group; Cytosol; Disease Susceptibility; Female; Humans; Immunocompromised Host; Infections; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Oxygen; Phosphoproteins; Platelet Activating Factor; Respiratory Burst; Subcellular Fractions; Superoxides; Tetradecanoylphorbol Acetate | 1996 |
Demonstration of reversible priming of human neutrophils using platelet-activating factor.
Topics: Adult; Azepines; Cell Adhesion; Cell Polarity; Cell Size; Cells, Cultured; Dihydropyridines; Enzyme Activation; Humans; Imidazoles; Macrophage-1 Antigen; Microspheres; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Burst; Superoxides; Time Factors; Triazoles; Tumor Necrosis Factor-alpha | 1996 |
Azelastine hydrochloride inhibits platelet activating factor-like activity in human eosinophils.
Topics: Animals; Asthma; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Histamine H1 Antagonists; Humans; N-Formylmethionine Leucyl-Phenylalanine; Phthalazines; Platelet Activating Factor; Platelet Aggregation | 1996 |
Transmigration of human neutrophils across airway epithelial cell monolayers is preferentially in the physiologic basolateral-to-apical direction.
Topics: CD18 Antigens; Cell Line; Cell Movement; Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5a; Epithelial Cells; Humans; Interleukin-1; Interleukin-8; Lung; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor | 1996 |
Membrane-stabilizing, anti-inflammatory interactions of macrolides with human neutrophils.
Topics: Adult; Anti-Asthmatic Agents; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Azithromycin; Calcimycin; Cell Membrane; Clarithromycin; Erythromycin; Humans; Ionophores; Luminescent Measurements; Lysophosphatidylcholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Respiratory Burst; Roxithromycin; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1996 |
Bactericidal/permeability-increasing protein release in whole blood ex vivo: strong induction by lipopolysaccharide and tumor necrosis factor-alpha.
Topics: Antigens, CD; Antimicrobial Cationic Peptides; Blood Bactericidal Activity; Blood Proteins; Complement C5a; Humans; Interleukin-1; Interleukin-8; Kinetics; Leukocyte Elastase; Lipopolysaccharides; Membrane Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Recombinant Proteins; Tumor Necrosis Factor-alpha; Zymosan | 1997 |
Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Chemotaxis; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Humans; Imidazoles; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphorylation; Platelet Activating Factor; Precipitin Tests; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Saccharomyces cerevisiae Proteins; Signal Transduction; Superoxides; Thiazoles; Time Factors; Virulence Factors, Bordetella | 1997 |
Induction of cytosolic phospholipase A2 activity by phosphatidic acid and diglycerides in permeabilized human neutrophils: interrelationship between phospholipases D and A2.
Topics: Arachidonic Acid; Bacterial Toxins; Cell Membrane Permeability; Cytosol; Diglycerides; Dose-Response Relationship, Drug; Enzyme Induction; Ethanol; Hemolysin Proteins; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Phospholipase D; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Tumor Necrosis Factor-alpha | 1997 |
Whole-blood incubation method to study neutrophil cytoskeletal dynamics.
Topics: Actins; Blood; Cell Separation; Cytoskeleton; Dose-Response Relationship, Drug; Flow Cytometry; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Time Factors | 1997 |
Cytokines regulate membrane-bound leukocyte elastase on neutrophils: a novel mechanism for effector activity.
Topics: Humans; Inflammation; Interleukin-8; Ions; Leukocyte Elastase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Surface Properties; Tumor Necrosis Factor-alpha; Up-Regulation | 1997 |
Purification and partial characterization of the PAF antagonist from the saliva of the leech Hirudo medicinalis.
Topics: Animals; Chromatography, Gel; Freeze Drying; Humans; Leeches; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Aggregation; Saliva; Superoxides | 1996 |
Effect of azelastine hydrochloride on release and production of platelet activating factor in human neutrophils.
Topics: Asthma; Biological Assay; Dose-Response Relationship, Drug; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phthalazines; Platelet Activating Factor; Platelet Aggregation | 1997 |
2',5'-Dihydroxychalcone as a potent chemical mediator and cyclooxygenase inhibitor.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Chalcone; Chalcones; Cyclooxygenase Inhibitors; Indomethacin; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Structure-Activity Relationship; Thrombin | 1997 |
Beta-adrenergic stimulation down-regulates neutrophil priming for superoxide generation, but not elastase release.
Topics: Adrenergic beta-Agonists; Cells, Cultured; Colforsin; Down-Regulation; Humans; Isoproterenol; Leukocyte Elastase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Receptors, Adrenergic, beta; Superoxides | 1997 |
Leukocyte contribution to parenchymal cell death in an experimental model of inflammation.
Topics: Animals; Cell Death; Chemotaxis, Leukocyte; Endothelium; Inflammation; Male; Mesentery; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rats; Rats, Wistar; Triazines; Xanthine Oxidase | 1997 |
The regulation by phosphorylation of 'priming' of phospholipase A2 activity in the neutrophil model system, differentiated HL60 cells.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Differentiation; Cell Membrane; Cytochalasin B; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; HL-60 Cells; Humans; Lysophospholipids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein-Tyrosine Kinases; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1997 |
Altered intracellular calcium signalling after PAF stimulations in polymorphonuclear leukocytes from asthmatic patients.
Topics: Adult; Asthma; Calcium; Female; Humans; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Signal Transduction | 1997 |
Pharmacological activity of PF-904 in guinea pig in vivo, and on human bronchus and neutrophils in vitro.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Capillary Permeability; Guinea Pigs; Humans; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyrazines; Superoxides; Thiadiazines | 1997 |
Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro.
Topics: Antibodies, Monoclonal; Antigens, CD; Apoptosis; Cells, Cultured; DNA Fragmentation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Kinetics; Leukotriene B4; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phytic Acid; Platelet Activating Factor; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Recombinant Proteins; Signal Transduction; Tumor Necrosis Factor-alpha | 1997 |
Hamycin inhibits IL-8-induced biologic response by modulating its receptor in human polymorphonuclear neutrophils.
Topics: Adjuvants, Immunologic; Antifungal Agents; Antigens, CD; Autoradiography; Biological Transport; Calcium; Cell Survival; Chemotaxis, Leukocyte; Diphenylhexatriene; Drug Combinations; Erythrocyte Membrane; Fluorescent Dyes; Glucose; Humans; Hydrogen Peroxide; Immunoblotting; Interleukin-8; Iodine Radioisotopes; Ligands; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitroblue Tetrazolium; Normal Distribution; Oxygen Consumption; Phospholipids; Platelet Activating Factor; Polyenes; Protein Binding; Receptors, Interleukin; Receptors, Interleukin-8A; Superoxides; Viscosity | 1997 |
Eosinophil chemotaxis induced by several biologically active substances and the effects of apafant on it in vitro.
Topics: Animals; Azepines; Bronchoalveolar Lavage Fluid; Chemotaxis; Eosinophils; Guinea Pigs; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles | 1997 |
Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons.
Topics: Animals; Animals, Newborn; Asthma; Capsaicin; Cells, Cultured; Coculture Techniques; Cytochalasin B; Enzyme-Linked Immunosorbent Assay; Eosinophils; Ganglia, Spinal; Humans; Myelin Basic Protein; N-Formylmethionine Leucyl-Phenylalanine; Neurons; Platelet Activating Factor; Polylysine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic, Seasonal; Substance P; Tissue Extracts | 1997 |
Receptor-mediated calcium entry is required for maximal effects of platelet activating factor primed responses in human neutrophils.
Topics: Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Binding Proteins; Chelating Agents; Cytochrome c Group; Egtazic Acid; Flow Cytometry; Fluorescent Dyes; Humans; Imidazoles; Indoles; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxides | 1997 |
Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function.
Topics: Androstadienes; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Chemotactic Factors; Chemotaxis, Leukocyte; Chromones; Cytokines; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Activating Factor; Protein Kinase Inhibitors; Protein Kinases; Respiratory Burst; Signal Transduction; Wortmannin; Zymosan | 1998 |
Influence of interleukin 1alpha on superoxide anion, platelet activating factor release and phospholipase A2 activity of naive and sensitized guinea-pig alveolar macrophages.
Topics: Animals; Cytokines; Dinoprostone; Guinea Pigs; Interleukin-1; Macrophages, Alveolar; N-Formylmethionine Leucyl-Phenylalanine; Oxygen; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Superoxides | 1997 |
Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkylating Agents; Animals; Azepines; Bronchitis; Capillary Permeability; Coloring Agents; Disease Models, Animal; Drug Interactions; Evans Blue; Indazoles; Leukotrienes; Male; Mechlorethamine; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rabbits; Reference Values; Trachea; Triazoles; Vasoconstrictor Agents | 1997 |
Superoxide release is involved in membrane potential changes in mouse peritoneal macrophages.
Topics: Animals; Luminescent Measurements; Macrophages, Peritoneal; Membrane Potentials; Mice; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Reactive Oxygen Species; Respiratory Burst; Superoxides | 1998 |
Activation of the prostaglandin EP4-receptor subtype is highly coupled to inhibition of N-formyl-methionyl-leucyl-phenylalanine-stimulated rat neutrophil aggregation.
Topics: Animals; Biphenyl Compounds; Cell Aggregation; Cyclic AMP; Dinoprostone; Epoprostenol; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Rolipram | 1998 |
Effects of some anti-asthma drugs on human eosinophil superoxide anions release and degranulation.
Topics: Anti-Asthmatic Agents; Cell Degranulation; Complement C5a; Dose-Response Relationship, Drug; Eosinophil Peroxidase; Eosinophils; Humans; Interleukin-5; N-Formylmethionine Leucyl-Phenylalanine; Peroxidases; Platelet Activating Factor; Superoxides | 1998 |
Ca2+ signalling delays in neutrophils: effects of prior exposure to platelet activating factor or formyl-met-leu-phe.
Topics: Calcium; Cells, Cultured; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Signal Transduction; Time Factors | 1998 |
Mechanisms of cell injury in rat mesentery and cremaster muscle.
Topics: Abdomen; Animals; Cell Adhesion; Endothelium, Vascular; Inflammation; Leukocyte Count; Leukopenia; Mesentery; Muscles; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rats; Rats, Wistar; Reactive Oxygen Species; Time Factors | 1998 |
Hepoxilin A3 inhibits agonist-evoked rise in free intracellular calcium in human neutrophils.
Topics: 8,11,14-Eicosatrienoic Acid; Calcium; Humans; In Vitro Techniques; Kinetics; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor | 1997 |
Oxatomide inhibits synthesis and release of platelet-activating factor in human neutrophils.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Asthmatic Agents; Asthma; Cell Extracts; Dose-Response Relationship, Drug; Guinea Pigs; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Platelet Activating Factor; Platelet Aggregation | 1998 |
Effect of serine proteinase inhibitors on intracellular free calcium rise in human polymorphonuclear leukocytes after stimulation with receptor agonists.
Topics: Adult; Calcium; Female; Humans; In Vitro Techniques; Intracellular Fluid; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenylmethylsulfonyl Fluoride; Platelet Activating Factor; Respiratory Burst; Serine Proteinase Inhibitors; Trypsin Inhibitors | 1998 |
Physiological activation of human neutrophils down-regulates CD53 cell surface antigen.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Calcium; Cells, Cultured; Down-Regulation; Humans; Ionomycin; Ionophores; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Platelet Activating Factor; RNA, Messenger; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tetraspanin 25; Tumor Necrosis Factor-alpha | 1998 |
Neutrophils rolling on immobilised platelets migrate into homotypic aggregates after activation.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Blood Platelets; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cell Aggregation; Cell Movement; Cell Size; Chemotaxis, Leukocyte; Hemorheology; Humans; Integrins; L-Selectin; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Endothelial Cell Adhesion Molecule-1; Receptors, Vitronectin | 1998 |
Effect of various agonists on nitric oxide generation by human polymorphonuclear leukocytes.
Topics: Concanavalin A; Enzyme Inhibitors; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1998 |
A CD18/ICAM-1-dependent pathway mediates eosinophil adhesion to human bronchial epithelial cells.
Topics: Antibodies, Monoclonal; CD18 Antigens; Cell Adhesion; Chemokine CCL11; Chemokine CCL4; Chemokine CCL5; Chemokines, CC; Complement C5a; Cytokines; Eosinophils; Epithelial Cells; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Kinetics; Leukotriene B4; Lung; Macrophage Inflammatory Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1998 |
Activation of the small GTPase rap1 in human neutrophils.
Topics: Dinoprostone; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; ral Guanine Nucleotide Exchange Factor; rap GTP-Binding Proteins | 1998 |
Chemotactic migration triggers IL-8 generation in neutrophilic leukocytes.
Topics: Animals; Caseins; Cattle; Cells, Cultured; Chemotaxis, Leukocyte; Complement C5a; Endothelium, Vascular; Humans; Interleukin-8; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Protein Synthesis Inhibitors; RNA, Messenger; Zymosan | 1999 |
Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils.
Topics: Acyltransferases; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Flavonoids; Humans; Imidazoles; Lipopolysaccharides; Microsomes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Pyridines; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Differential fMet-Leu-Phe- and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils.
Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Humans; In Vitro Techniques; Kinetics; Mitogen-Activated Protein Kinase 1; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Proteins; ral GTP-Binding Proteins; rap GTP-Binding Proteins; ras GTPase-Activating Proteins; Signal Transduction; Tetradecanoylphorbol Acetate | 1999 |
Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Humans; Mice; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Platelet Activating Factor; Rabbits; Rats; Respiratory Burst; Signal Transduction; Species Specificity; Swine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1999 |
Release of O2- by human umbilical cord blood-derived eosinophils: role of intra- and extracellular calcium.
Topics: Calcium; Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophils; Fetal Blood; Humans; Imidazoles; Ionomycin; Magnesium; N-Formylmethionine Leucyl-Phenylalanine; Nickel; Oxygen; Platelet Activating Factor; Respiratory Burst; Spectrometry, Fluorescence; Thapsigargin | 1999 |
[Post-receptor formation of active forms of oxygen in nonphagocytic cells].
Topics: Animals; Cell Line; Epidermal Growth Factor; ErbB Receptors; Interferon-gamma; Lipopolysaccharides; Mice; N-Formylmethionine Leucyl-Phenylalanine; Phagocytes; Platelet Activating Factor; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1999 |
Interactions between neutrophil gelatinase-associated lipocalin and natural lipophilic ligands.
Topics: Acute-Phase Proteins; Carrier Proteins; Chromatography, Affinity; Chromatography, Liquid; Enzyme Inhibitors; Gelatinases; Humans; Leukotriene B4; Ligands; Lipocalin-2; Lipocalins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Oncogene Proteins; Platelet Activating Factor; Precipitin Tests; Protein Binding; Proto-Oncogene Proteins; Spectrometry, Fluorescence | 1999 |
Mechanisms for regulation of fluid shear stress response in circulating leukocytes.
Topics: Aminoquinolines; Animals; Cell Adhesion; Cyclic GMP; Humans; In Vitro Techniques; Leukocytes; Methylene Blue; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Formylmethionine Leucyl-Phenylalanine; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Platelet Activating Factor; Rats; Rats, Wistar; Stress, Physiological | 2000 |
Expression of serum- and glucocorticoid-regulated kinase (sgk) mRNA is up-regulated by GM-CSF and other proinflammatory mediators in human granulocytes.
Topics: Adult; Amanitins; Dactinomycin; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; HL-60 Cells; Humans; Immediate-Early Proteins; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; Nuclear Proteins; Nucleic Acid Synthesis Inhibitors; Platelet Activating Factor; Protein Serine-Threonine Kinases; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2000 |
Integrin alpha(2)beta(1) (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue.
Topics: Adult; Animals; Antibodies, Monoclonal; Blister; Cell Adhesion; Chemotactic Factors; Chemotaxis, Leukocyte; Collagen; Gelatin; Gels; Humans; Inflammation; Integrin beta1; Integrins; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Microscopy, Video; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Platelet Activating Factor; Rats; Rats, Wistar; Receptors, Collagen | 2000 |
Differential regulation of Ca2+ influx by fMLP and PAF in human neutrophils: possible involvement of store-operated Ca2+ channel.
Topics: Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cyclic GMP; Egtazic Acid; Enzyme Activation; Humans; Imidazoles; Loperamide; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Protein Kinase C; Tetradecanoylphorbol Acetate | 2000 |
Reduced basal and stimulated leukocyte adherence in tumor endothelium of experimental pancreatic cancer.
Topics: Animals; Blood Flow Velocity; Blood Vessels; Carcinoma; Cell Adhesion; Chemotactic Factors; Endothelium; Endothelium, Vascular; Erythrocytes; Leukocytes; Lymphocyte Culture Test, Mixed; N-Formylmethionine Leucyl-Phenylalanine; Pancreatic Neoplasms; Platelet Activating Factor; Rats; Venules | 1999 |
Activation of G-protein coupled fMLP or PAF receptor directly triggers glucose transporter type 1 (GLUT1) translocation in Chinese hamster ovary (CHO) cells stably expressing fMLP or PAF receptor.
Topics: Amino Acid Sequence; Animals; Biological Transport; Cells, Cultured; Chemotactic Factors; CHO Cells; Cricetinae; Deoxyglucose; Glucose Transporter Type 1; GTP-Binding Proteins; Humans; Macrophages, Peritoneal; Male; Molecular Sequence Data; Monosaccharide Transport Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Peptide; Recombinant Fusion Proteins | 2000 |
Interleukin-8 is a chemo-attractant for eosinophils purified from subjects with a blood eosinophilia but not from normal healthy subjects.
Topics: Cells, Cultured; Chemotactic Factors; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Eosinophilia; Eosinophils; Fetal Blood; Humans; Interleukin-3; Interleukin-5; Interleukin-8; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor | 1993 |
Major trauma enhances store-operated calcium influx in human neutrophils.
Topics: Adult; Calcium; Complement C5a; Female; Humans; In Vitro Techniques; Interleukin-8; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Spectrophotometry; Wounds and Injuries | 2000 |
Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils.
Topics: Cell Adhesion; Cell Migration Inhibition; Cells, Cultured; Chemokine CXCL1; Chemokine CXCL5; Chemokines, CXC; Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5a; Dose-Response Relationship, Immunologic; Endothelium, Vascular; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-8; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Receptors, Chemokine; Receptors, Interleukin; Receptors, Interleukin-8B; Umbilical Veins | 2000 |
A surrogate method for assessment of beta(2)-integrin-dependent adhesion of human eosinophils to ICAM-1.
Topics: Androstadienes; Butadienes; CD18 Antigens; Cell Adhesion; Dose-Response Relationship, Drug; Eosinophils; Genistein; Humans; Hypersensitivity, Immediate; Integrins; Intercellular Adhesion Molecule-1; Interleukin-5; N-Formylmethionine Leucyl-Phenylalanine; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Platelet Activating Factor; Protein Kinase Inhibitors; Serum Albumin, Bovine; Wortmannin | 2000 |
The role of reactive oxygen species in membrane potential changes in macrophages and astrocytes.
Topics: Anaphylatoxins; Animals; Astrocytes; Catalase; Cell Membrane; Fluorescent Dyes; Glioblastoma; Humans; Interferon-gamma; Lipopolysaccharides; Macrophages; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Reactive Oxygen Species; Superoxide Dismutase; Tumor Cells, Cultured | 2000 |
Hypertonic saline inhibits neutrophil (PMN) priming via attenuation of p38 MAPK signaling.
Topics: CD18 Antigens; Cells, Cultured; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen; p38 Mitogen-Activated Protein Kinases; Platelet Activating Factor; Saline Solution, Hypertonic; Superoxides | 2000 |
Sequential migration of neutrophils across monolayers of endothelial and epithelial cells.
Topics: Adenocarcinoma; Bronchi; CD18 Antigens; Cell Communication; Cell Line, Transformed; Cell Polarity; Cells, Cultured; Chemotaxis, Leukocyte; Coculture Techniques; Complement C5a; Endothelium, Vascular; Epithelial Cells; Humans; Interleukin-1; Interleukin-6; Interleukin-8; Lung; Lung Neoplasms; Microscopy, Electron; Models, Biological; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Endothelial Cell Adhesion Molecule-1; Recombinant Proteins; Tumor Cells, Cultured; Umbilical Veins | 2000 |
Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Azepines; Calcium; Cytosol; Enzyme Inhibitors; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rabbits; Terpenes; Tosylphenylalanyl Chloromethyl Ketone; Triazoles | 2000 |
Inhibition of neutrophil L-selectin shedding: a potential anti-inflammatory effect of aprotinin.
Topics: Aprotinin; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Inflammation; L-Selectin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Serine Proteinase Inhibitors | 2000 |
Dissipative metabolic patterns respond during neutrophil transmembrane signaling.
Topics: Antigen-Antibody Complex; Chemotaxis, Leukocyte; Humans; Interferon-gamma; Interleukin-6; Interleukin-8; Leukotriene B4; Ligands; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; NADP; Neutrophils; Platelet Activating Factor; Signal Transduction; Spectrometry, Fluorescence | 2001 |
RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses.
Topics: Animals; Calcium; Calcium Signaling; Cytoplasm; Genetic Vectors; Hydrolysis; N-Formylmethionine Leucyl-Phenylalanine; Peptide Fragments; Phosphatidylinositols; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Peptide; RGS Proteins; Transfection; Tumor Cells, Cultured | 2001 |
Blood transfusion and the two-insult model of post-injury multiple organ failure.
Topics: Blood Preservation; Cell Adhesion; Cells, Cultured; Chemotaxis, Leukocyte; Drug Synergism; Endothelium, Vascular; Fibrinogen; Humans; Inflammation; Lysophosphatidylcholines; Models, Biological; Multiple Organ Failure; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidative Stress; Platelet Activating Factor; Risk; Superoxides; Transfusion Reaction | 2001 |
Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils.
Topics: Activating Transcription Factor 2; Calcium; Calcium Signaling; Chelating Agents; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Humans; Ionomycin; Ionophores; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activating Factor; Proto-Oncogene Proteins; Thapsigargin; Transcription Factors | 2001 |
Decoupling of intracellular calcium signaling in granulocytes after exhaustive exercise.
Topics: Adult; Analysis of Variance; Calcium Signaling; Exercise; Exercise Test; Flow Cytometry; Granulocytes; Humans; Male; N-Formylmethionine Leucyl-Phenylalanine; Oxygen Consumption; Phagocytosis; Platelet Activating Factor; Respiratory Burst; Signal Transduction | 2001 |
Agonist-dependent failure of neutrophil function in diabetes correlates with extent of hyperglycemia.
Topics: Adult; Blood Glucose; Calcimycin; Cells, Cultured; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hyperglycemia; Leukotriene B4; Lysosomes; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Zymosan | 2001 |
PAF receptor antagonist modulates neutrophil responses with thermal injury in vivo.
Topics: Animals; Burns; Calcium; Carcinogens; Male; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Tetradecanoylphorbol Acetate | 2001 |
Hemofiltration reduces the serum priming activity on neutrophil chemiluminescence in septic patients.
Topics: Acute Kidney Injury; Aged; Blood Physiological Phenomena; Hemofiltration; Humans; Interleukin-8; Luminescent Measurements; Middle Aged; Multiple Organ Failure; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Reference Values; Respiratory Burst; Shock, Septic; Uremia | 2001 |
Activation-induced mobilization of secretory vesicles in bovine neutrophils.
Topics: Alkaline Phosphatase; Animals; Cattle; Inflammation Mediators; Interleukin-8; Leukotriene B4; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peroxidase; Platelet Activating Factor; Secretory Vesicles; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2001 |
Evidence for the involvement of the NADPH oxidase enzyme complex in the optimal accumulation of Platelet-activating factor in the human cell line PLB-985.
Topics: Calcimycin; Calcium; Cell Line; Gas Chromatography-Mass Spectrometry; Glycerylphosphorylcholine; Humans; Ionophores; Leukemia, Myeloid; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Phosphatidylcholines; Platelet Activating Factor; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Superoxides; Tetradecanoylphorbol Acetate | 2001 |
A neutrophil multitarget functional bioassay to detect anti-inflammatory natural products.
Topics: alpha-Amylases; Anti-Inflammatory Agents; Benzoylarginine Nitroanilide; Biological Assay; Biological Products; Cytochalasin B; Digitalis; Digitonin; Digitoxin; Dose-Response Relationship, Immunologic; Hemolysis; Humans; Lamiaceae; Leukocyte Elastase; Magnoliopsida; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Peptides; Plant Proteins; Plants, Medicinal; Platelet Activating Factor; Superoxides; Sweden; Tabernaemontana; Trypsin Inhibitors; Violaceae | 2002 |
Potential role of IL-8, platelet-activating factor and TNF-alpha in the sequestration of neutrophils in the lung: effects on neutrophil deformability, adhesion receptor expression, and chemotaxis.
Topics: Cell Adhesion; Cell Movement; Cell Size; Chemotaxis, Leukocyte; Enzyme Activation; Humans; In Vitro Techniques; Inflammation Mediators; Interleukin-8; L-Selectin; Lung; Macrophage-1 Antigen; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Tumor Necrosis Factor-alpha | 2002 |
Cholesterol-modulating agents selectively inhibit calcium influx induced by chemoattractants in human neutrophils.
Topics: beta-Cyclodextrins; Calcium; Cell Membrane; Cholesterol; Cyclodextrins; Cytoplasm; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipase D; Phosphorylation; Platelet Activating Factor; Protein Structure, Tertiary; Superoxides; Time Factors; Tyrosine | 2002 |
Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock.
Topics: Animals; Blood Pressure; Endopeptidases; Esters; Gabexate; Guanidines; Humans; In Vitro Techniques; Inflammation; Intestinal Mucosa; Intestines; Leukocytes; Male; Multiple Organ Failure; N-Formylmethionine Leucyl-Phenylalanine; Neutropenia; Phospholipases A; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reperfusion; Serine Endopeptidases; Serine Proteinase Inhibitors; Shock; Splanchnic Circulation; Survival Rate | 2002 |
Dissociation of the PAF-receptor from NADPH oxidase and adenylate cyclase in human neutrophils results in accelerated influx and delayed clearance of cytosolic calcium.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenylyl Cyclases; Bucladesine; Calcium; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytosol; Homeostasis; Humans; In Vitro Techniques; Leukocyte Elastase; Luminescent Measurements; Membrane Potentials; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; Phenethylamines; Phosphodiesterase Inhibitors; Platelet Activating Factor; Platelet Membrane Glycoproteins; Purinergic P1 Receptor Agonists; Radioimmunoassay; Receptor, Adenosine A2A; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Rolipram; Spectrometry, Fluorescence; Superoxides | 2002 |
Augmentation of the neutrophil respiratory burst through the action of advanced glycation end products: a potential contributor to vascular oxidant stress.
Topics: Adult; Blood Vessels; Dose-Response Relationship, Drug; Drug Synergism; Glycation End Products, Advanced; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidative Stress; Physical Stimulation; Platelet Activating Factor; Respiratory Burst; Serum Albumin; Tumor Necrosis Factor-alpha | 2002 |
Regulation of phosphatidylinositol 3-kinase activity and phosphatidylinositol 3,4,5-trisphosphate accumulation by neutrophil priming agents.
Topics: Animals; Cattle; Cell Line; COS Cells; Cytochalasin B; Enzyme Activation; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inositol Phosphates; Isoenzymes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Platelet Activating Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Superoxides; Tumor Necrosis Factor-alpha | 2002 |
Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases.
Topics: Acetyltransferases; Acyltransferases; Calcimycin; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Humans; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Platelet Activating Factor | 2002 |
Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10.
Topics: Arachidonic Acid; Autocrine Communication; Azepines; Escherichia coli; Humans; In Vitro Techniques; Indoles; Interleukin-10; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Lipopolysaccharide Receptors; Lipopolysaccharides; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Prospective Studies; Respiratory Burst; Superoxides; Triazoles | 2002 |
Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents.
Topics: Adult; Apoptosis; Calcium Signaling; Cell Polarity; Cell Size; Chromones; Enzyme Activation; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptide Fragments; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Recombinant Proteins; Respiratory Burst; Signal Transduction; Sphingosine; Substance P; Superoxides; Tumor Necrosis Factor-alpha | 2002 |
Effects of antidepressants on function and viability of human neutrophils.
Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cell Survival; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Indicators and Reagents; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Superoxides | 2003 |
Effects of heparin and related molecules upon neutrophil aggregation and elastase release in vitro.
Topics: Boron Compounds; Cell Aggregation; Dextran Sulfate; Heparin; Heparin, Low-Molecular-Weight; Humans; Hyaluronic Acid; Leukocyte Elastase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Tumor Necrosis Factor-alpha | 2003 |
Actin assembly is a crucial factor for superoxide anion generation from adherent human eosinophils.
Topics: Actins; Calcium; CD18 Antigens; Cell Adhesion; Cell Degranulation; Cytochalasin B; Cytochalasin D; Eosinophils; Humans; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Phosphoproteins; Platelet Activating Factor; Protein Kinase C; Superoxides | 2003 |
Matrix metalloproteinase-9 release from human leukocytes.
Topics: Asthma; Complement C5a; Cytochalasin B; Dose-Response Relationship, Drug; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Leukocytes; Leukocytes, Mononuclear; Matrix Metalloproteinase 9; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Platelet Activating Factor; Pulmonary Disease, Chronic Obstructive | 2003 |
Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Arachidonic Acids; Basophils; Cells, Cultured; Complement C5a; Enzyme Inhibitors; Humans; Interleukin-3; Leukotriene C4; N-Formylmethionine Leucyl-Phenylalanine; Organophosphonates; Phospholipases A2; Platelet Activating Factor; Receptors, IgE; Recombinant Proteins; Tetradecanoylphorbol Acetate | 2003 |
[Lack of stimulation of CD11b/CD18 induced leukocyte adhesioin by platelet activating factor (PAF) and f-MLP in malignant tumor endothelium in experimental pancreas cancer of the rat].
Topics: Animals; Blood Flow Velocity; Carcinoma, Pancreatic Ductal; CD11b Antigen; CD18 Antigens; Cell Adhesion; Endothelium, Vascular; Leukocytes; Male; N-Formylmethionine Leucyl-Phenylalanine; Neoplasm Transplantation; Pancreatic Neoplasms; Platelet Activating Factor; Rats; Rats, Inbred Lew | 1998 |
Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte-endothelial cell interactions in vivo.
Topics: Adenosine Monophosphate; Alkaloids; Animals; Calcium; Cell Communication; Cell Line; Colforsin; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Leukocyte Rolling; Leukocytes; Male; Microscopy, Video; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenanthrenes; Plant Extracts; Platelet Activating Factor; Protein Binding; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rolipram | 2003 |
Obligatory role of lipid mediators in platelet-neutrophil adhesion.
Topics: Blood Platelets; Cell Adhesion; Cells, Cultured; Hemostasis; Humans; Inflammation Mediators; Leukotrienes; Lipid Metabolism; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Platelet Adhesiveness; Thrombin; Thromboxane A2 | 2003 |
Tea polyphenols inhibit acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and platelet-activating factor-induced platelet aggregation.
Topics: Acetyltransferases; Animals; Biflavonoids; Catechin; Chelating Agents; Flavonoids; Models, Animal; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenols; Plant Extracts; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Polyphenols; Rabbits; Rheum; Tea; Time Factors | 2004 |
Itraconazole antagonizes store-operated influx of calcium into chemoattractant-activated human neutrophils.
Topics: Antifungal Agents; Biological Transport, Active; Calcium; Calcium Channels; Cell Membrane; Chemotaxis, Leukocyte; Cytosol; Humans; Itraconazole; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Spectrometry, Fluorescence | 2004 |
Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase.
Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Ligands; Luminescent Measurements; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Platelet Activating Factor; Pyridines; Reactive Oxygen Species; Swine; Tumor Necrosis Factor-alpha; Zymosan | 2004 |
The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8.
Topics: Adult; Cells, Cultured; Chemotactic Factors; Chemotaxis, Leukocyte; Cytoskeleton; Enzyme Activation; Humans; Interleukin-8; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; Oligopeptides; Platelet Activating Factor; Receptors, Formyl Peptide; Receptors, Interleukin-8A; Receptors, Interleukin-8B; Signal Transduction; Tumor Necrosis Factor-alpha | 2004 |
A new model for studying eosinophil migration across cultured intestinal epithelial monolayers.
Topics: Cell Movement; Chemokine CCL11; Chemokines, CC; Chemotactic Factors, Eosinophil; Eosinophils; Fluorescence; HL-60 Cells; Humans; Intestinal Mucosa; Leukocyte Count; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Time Factors | 2004 |
Controlled pseudopod extension of human neutrophils stimulated with different chemoattractants.
Topics: Actins; ADP Ribose Transferases; Amides; Anaphylatoxins; Androstadienes; Botulinum Toxins; Chemotactic Factors; Chemotaxis; Humans; Interleukin-8; Intracellular Signaling Peptides and Proteins; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Activating Factor; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pseudopodia; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Wortmannin | 2004 |
Andrographolide interferes with binding of nuclear factor-kappaB to DNA in HL-60-derived neutrophilic cells.
Topics: Anti-Inflammatory Agents; Cell Survival; Diterpenes; DNA; HL-60 Cells; Humans; Luciferases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activating Factor | 2005 |
Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP.
Topics: Animals; Capillary Permeability; CD11b Antigen; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; Humans; In Vitro Techniques; Lung; Lysophosphatidylcholines; Mice; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; Oxidants; Phosphoproteins; Platelet Activating Factor; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Superoxides; Tetradecanoylphorbol Acetate; Up-Regulation | 2005 |
Different pathways leading to activation of extracellular signal-regulated kinase and p38 MAP kinase by formyl-methionyl-leucyl-phenylalanine or platelet activating factor in human neutrophils.
Topics: Androstadienes; Aristolochic Acids; Calcium; Calcium Channel Blockers; Calcium Channels; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Indoles; Maleimides; Models, Biological; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Naphthalenes; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein Isoforms; Protein Kinase C; Pyrrolidinones; Type C Phospholipases; Wortmannin | 2005 |
Critical role of proline-rich tyrosine kinase 2 in reversion of the adhesion-mediated suppression of reactive oxygen species generation by human neutrophils.
Topics: Cell Adhesion; Cell Cycle Proteins; Chemotactic Factors; Down-Regulation; Enzyme Activation; Focal Adhesion Kinase 2; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Oxidants; Phosphorylation; Platelet Activating Factor; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; rac GTP-Binding Proteins; RAC2 GTP-Binding Protein; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2005 |
Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro.
Topics: Animals; Annexin A1; CD11b Antigen; Chemotaxis; Disease Models, Animal; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Muscle, Skeletal; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Time Factors; Zymosan | 2005 |
Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils.
Topics: Calcium; Calcium Channel Blockers; Calcium Signaling; Cresols; Cyclic ADP-Ribose; Estrenes; HL-60 Cells; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Pyrrolidinones; Respiratory Burst; Ryanodine Receptor Calcium Release Channel; Type C Phospholipases | 2005 |
3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells.
Topics: Anti-Inflammatory Agents; Blotting, Western; Calcium; Calcium Channel Agonists; Cell Line; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; In Vitro Techniques; Inosine Triphosphate; Mitogen-Activated Protein Kinases; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Platelet Activating Factor; Triterpenes | 2006 |
Evaluation of in-vitro anti-inflammatory activity of some 2-alkyl-4,6-dimethoxy-1,3,5-triazines.
Topics: Anti-Inflammatory Agents; Cell Adhesion; Cells, Cultured; Endothelial Cells; Humans; Interleukin-1; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxides; Tetradecanoylphorbol Acetate; Triazines; Tumor Necrosis Factor-alpha | 2006 |
Characterization of an activation factor released from human neutrophils after stimulation by triclinic monosodium urate crystals.
Topics: Calcium; Chemotaxis, Leukocyte; Crystallization; Humans; Interleukin-8; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Pertussis Toxin; Phosphorylation; Platelet Activating Factor; Receptors, Formyl Peptide; Tyrosine; Uric Acid | 2006 |
Thermal injury-induced priming effect of neutrophil is TNF-alpha and P38 dependent.
Topics: Animals; Burns; MAP Kinase Signaling System; Mice; Mice, Knockout; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; p38 Mitogen-Activated Protein Kinases; Platelet Activating Factor; Reactive Oxygen Species; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor-alpha | 2006 |
Toll-like receptor agonists stimulate human neutrophil migration via activation of mitogen-activated protein kinases.
Topics: Butadienes; Chemotaxis, Leukocyte; Dose-Response Relationship, Immunologic; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Lipopolysaccharides; Lipoproteins; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activating Factor; Pyridines; Toll-Like Receptors | 2008 |
Regulation of VASP serine 157 phosphorylation in human neutrophils after stimulation by a chemoattractant.
Topics: Actins; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Chemotaxis; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Interleukin-8; Leukotriene B4; Microfilament Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Serine; Signal Transduction; Tumor Necrosis Factor-alpha | 2007 |
Respiratory burst function of ovine neutrophils.
Topics: Animals; Immunity, Innate; Immunologic Techniques; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Reactive Oxygen Species; Respiratory Burst; Sheep; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2009 |
Effects of acrolein on leukotriene biosynthesis in human neutrophils.
Topics: Acrolein; Air Pollutants; Arachidonate 5-Lipoxygenase; Calcimycin; Dose-Response Relationship, Drug; Drug Interactions; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukotrienes; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases | 2008 |
Persistency and pathway of isoflurane-induced inhibition of superoxide production by neutrophils.
Topics: Anesthetics, Inhalation; Animals; Calcimycin; Dogs; Isoflurane; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Protein Kinase C; Signal Transduction; Spectrophotometry; Superoxides; Tetradecanoylphorbol Acetate; Time Factors | 2010 |
Inhibitors of TRP channels reveal stimulus-dependent differential activation of Ca2+ influx pathways in human neutrophil granulocytes.
Topics: Adenosine Diphosphate Ribose; Aniline Compounds; Calcium; Cinnamates; Fluorescent Dyes; Humans; Manganese; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; ortho-Aminobenzoates; Platelet Activating Factor; Thapsigargin; TRPM Cation Channels; Xanthenes | 2009 |
Effects of ropivacaine on adhesion molecule CD11b expression and function in human neutrophils.
Topics: 1-Butanol; Amides; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; CD11 Antigens; Cell Adhesion; Egtazic Acid; Endothelial Cells; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipase D; Platelet Activating Factor; Ropivacaine; Umbilical Veins | 2010 |
Discrimination between receptor- and store-operated Ca(2+) influx in human neutrophils.
Topics: Boron Compounds; Calcium; Humans; Immunologic Factors; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Receptors, Calcium-Sensing; Spectrometry, Fluorescence; Strontium | 2010 |
The nondepolarizing, normokalemic cardioplegia formulation adenosine-lidocaine (adenocaine) exerts anti-neutrophil effects by synergistic actions of its components.
Topics: Adenosine; Anesthetics, Local; Animals; Cardioplegic Solutions; CD11 Antigens; CD18 Antigens; Cell Adhesion; Cells, Cultured; Coculture Techniques; Coronary Vessels; Cytochalasin B; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Flow Cytometry; Lidocaine; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Superoxides; Swine; Time Factors; Transendothelial and Transepithelial Migration | 2012 |
Effect of granulocyte-macrophage colony-stimulating factor on neutrophil function in idiopathic bronchiectasis.
Topics: Aged; Bronchiectasis; Case-Control Studies; Cells, Cultured; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Platelet Activating Factor; Superoxides; Zymosan | 2013 |
Systematic single cell analysis of migration and morphological changes of human neutrophils over stimulus concentration gradients.
Topics: Adult; Chemotaxis, Leukocyte; Female; Humans; Interleukin-8; Leukotriene B4; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Primary Cell Culture; Single-Cell Analysis | 2014 |
Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection.
Topics: Animals; Bacterial Proteins; Carrier Proteins; Carrier State; Cell Wall; Haemophilus Infections; Haemophilus influenzae; Humans; Immune Evasion; Immunity, Innate; Immunoglobulin D; Lipoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Mimicry; N-Formylmethionine Leucyl-Phenylalanine; Nasal Cavity; Neutropenia; Neutrophil Activation; Neutrophils; Phagocytosis; Phosphorylcholine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pneumococcal Infections; Proteolysis; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Species Specificity; Streptococcus pneumoniae | 2015 |
Formyl Met-Leu-Phe-Stimulated FPR1 Phosphorylation in Plate-Adherent Human Neutrophils: Enhanced Proteolysis but Lack of Inhibition by Platelet-Activating Factor.
Topics: Alarmins; Cell Adhesion; Cells, Cultured; Humans; Isoflurophate; L-Lactate Dehydrogenase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pathogen-Associated Molecular Pattern Molecules; Peptide Fragments; Phosphorylation; Platelet Activating Factor; Proteolysis; Receptors, Formyl Peptide | 2018 |