Page last updated: 2024-09-02

1-hexadecyl-2-acetyl-glycero-3-phosphocholine and methotrexate

1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with methotrexate in 7 studies

Compound Research Comparison

Studies
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Trials
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Recent Studies (post-2010)
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Studies
(methotrexate)
Trials
(methotrexate)
Recent Studies (post-2010) (methotrexate)
9,15618755241,5935,66611,969

Protein Interaction Comparison

ProteinTaxonomy1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50)methotrexate (IC50)
Thymidylate synthase Escherichia coli1.8
nuclear receptor coactivator 3 isoform aHomo sapiens (human)0.211
Toll-like receptor 4Homo sapiens (human)1.04
Fatty-acid amide hydrolase 1Mus musculus (house mouse)0.08
Dihydrofolate reductaseHomo sapiens (human)0.0522
Dihydrofolate reductaseMus musculus (house mouse)0.0331
Dihydrofolate reductase Bos taurus (cattle)0.0348
Dihydrofolate reductaseGallus gallus (chicken)0.0545
Dihydrofolate reductaseEnterococcus faecium0.0014
Dihydrofolate reductaseLacticaseibacillus casei0.0138
Thymidylate synthaseHomo sapiens (human)0.343
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.0147
Thymidylate synthaseEscherichia coli K-120.0181
Dihydrofolate reductaseEscherichia coli K-120.1529
Bifunctional dihydrofolate reductase-thymidylate synthasePlasmodium falciparum K10.084
Folate receptor betaHomo sapiens (human)0.1585
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.0011
Cytochrome P450 11B1, mitochondrial Bos taurus (cattle)0.0012
Folate receptor alphaHomo sapiens (human)0.2263
Dihydrofolate reductasePneumocystis carinii0.0717
Histidine decarboxylaseRattus norvegicus (Norway rat)0.0014
Trifunctional purine biosynthetic protein adenosine-3Homo sapiens (human)0.01
Bifunctional purine biosynthesis protein ATICHomo sapiens (human)0.01
Delta-type opioid receptorRattus norvegicus (Norway rat)0.003
Mu-type opioid receptorRattus norvegicus (Norway rat)0.003
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.003
Reduced folate transporterHomo sapiens (human)0.012
Dihydrofolate reductaseMycobacterium tuberculosis H37Rv0.0174
Folylpolyglutamate synthase, mitochondrialHomo sapiens (human)3.2
Bifunctional dihydrofolate reductase-thymidylate synthaseToxoplasma gondii0.0547
Bifunctional dihydrofolate reductase-thymidylate synthaseTrypanosoma cruzi0.11
Dihydrofolate reductase Bacillus anthracis0.0136
Dihydrofolate reductaseRattus norvegicus (Norway rat)0.0047
Proton-coupled folate transporterHomo sapiens (human)0.1207

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's5 (71.43)18.2507
2000's0 (0.00)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Asako, H; Baethge, BA; Granger, DN; Kubes, P; Wolf, RE1
Austen, KF; Benincaso, AI; Coblyn, JS; Larkin, JK; Sperling, RI; Weinblatt, ME1
Browning, JL; Cirino, G; Flower, RJ; Peers, SH; Pepinsky, RB1
Tsai, JJ; Wang, SR; Wang, TF1
Asako, H; Granger, DN; Wolf, RE1
Chen, W; Li, S; Liu, B; Zhang, H1
Liu, J; Zong, RK1

Other Studies

7 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and methotrexate

ArticleYear
Colchicine and methotrexate reduce leukocyte adherence and emigration in rat mesenteric venules.
    Inflammation, 1992, Volume: 16, Issue:1

    Topics: Animals; Cell Adhesion; Cell Migration Inhibition; Colchicine; Flow Cytometry; Humans; Leukocytes; Leukotriene B4; Male; Mesentery; Methotrexate; Microscopy; Neutrophils; Platelet Activating Factor; Rats; Rats, Inbred Strains; Venules; Video Recording

1992
Inhibition of leukotriene B4 synthesis in neutrophils from patients with rheumatoid arthritis by a single oral dose of methotrexate.
    Arthritis and rheumatism, 1990, Volume: 33, Issue:8

    Topics: Aged; Arachidonic Acid; Arachidonic Acids; Arthritis, Rheumatoid; Calcimycin; Chemotaxis, Leukocyte; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Methotrexate; Middle Aged; Neutrophils; Phospholipases; Platelet Activating Factor

1990
Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test.
    Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:9

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adrenalectomy; Animals; Annexins; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Carrageenan; Dexamethasone; Dextrans; Edema; Glycoproteins; Indomethacin; Male; Methotrexate; p-Methoxy-N-methylphenethylamine; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Pyrazoles; Rats; Rats, Inbred Strains; Recombinant Proteins; Serotonin

1989
The inhibitory effect of methotrexate on PAF-induced neutrophil and eosinophil locomotion in asthmatic patients.
    Asian Pacific journal of allergy and immunology, 1994, Volume: 12, Issue:1

    Topics: Asthma; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Eosinophils; Humans; Leukocytes, Mononuclear; Leukotriene B4; Methotrexate; Neutrophils; Platelet Activating Factor

1994
Leukocyte adherence in rat mesenteric venules: effects of adenosine and methotrexate.
    Gastroenterology, 1993, Volume: 104, Issue:1

    Topics: Adenosine; Animals; Cell Adhesion; Endothelium, Vascular; Leukocyte Adherence Inhibition Test; Leukocytes; Leukotriene B4; Male; Methotrexate; Platelet Activating Factor; Purinergic Antagonists; Rats; Rats, Sprague-Dawley; Splanchnic Circulation; Venules

1993
Effects of MTX and BN52021 on PAF-induced chemotaxis of PMNs and intraepidermal accumulation of inflammatory cells in guinea pigs.
    Chinese medical journal, 1996, Volume: 109, Issue:6

    Topics: Animals; Chemotaxis, Leukocyte; Dermatologic Agents; Diterpenes; Drugs, Chinese Herbal; Epidermis; Ginkgolides; Guinea Pigs; Inflammation; Lactones; Methotrexate; Neutrophils; Platelet Activating Factor; Random Allocation

1996
[Effects of Chinese herbal medicine Xinfeng Capsule on expressions of platelet-activating factor and interleukins 6 and 17 in peripheral blood of rats with adjuvant arthritis].
    Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2011, Volume: 9, Issue:12

    Topics: Animals; Arthritis, Experimental; Drugs, Chinese Herbal; Interleukin-17; Interleukin-6; Male; Methotrexate; Phytotherapy; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Tripterygium

2011