Page last updated: 2024-09-02

1-hexadecyl-2-acetyl-glycero-3-phosphocholine and lexipafant

1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with lexipafant in 48 studies

Compound Research Comparison

Studies
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Trials
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Recent Studies (post-2010)
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Studies
(lexipafant)
Trials
(lexipafant)
Recent Studies (post-2010) (lexipafant)
9,15618755270110

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's23 (47.92)18.2507
2000's25 (52.08)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abu-Zidan, FM; Lennquist, S; Walther, S5
Abu-Zidan, FM; Walther, S1
Galloway, SW; Kingsnorth, AN1
Kingsnorth, AN1
Curtis, LD1
Baxter, JN; Curran, FJ; Imrie, CW; McKay, C; Sharples, CE; Young, CA1
Colvin, SB; Eng, K; Galloway, AC; Grossi, EA; Jacobs, CE; Marcus, SG; Schwartz, DS; Schwartz, JD; Shamamian, P; Steiner, F; Tayyarah, M1
Balsa, D; Ferrando, R; Forn, J; Garcia-Rafanell, J; Giral, M; Merlos, M1
Abu-Zidan, FM2
Smail, N; Spapen, H; Verhaeghe, V; Vincent, JL; Zhang, H1
Andersson, R; Deng, X; Ihse, I; Soltesz, V; Sun, Z; Wang, X1
Andersson, R; Börjesson, A; Sun, Z; Wang, X1
Aldman, M; Andersson, R; Börjesson, A; Deng, X; Haraldsen, P; Leveau, P; Sun, Z; Wang, X1
Bewsey, K; Djuricin, G; Gattuso, P; Liu, Q; Nathan, C; Prinz, RA; Rossi, H; Weinstein, RA1
Epstein, LG; Kieburtz, K; Marder, K; McArthur, JC; McDermott, MP; Sacktor, N; Schifitto, G; Small, S1
Imrie, CW; McKay, CJ2
Andersson, R; Börjesson, A; Deng, X; Lasson, A; Soltesz, V; Sun, Z; Wang, X1
Bakker, J; Curtis, L; Spapen, H; Vincent, JL; Webster, NR1
Brady, M; Christmas, S; Neoptolemos, J; Slavin, J; Sutton, R1
Curtis, LD; Imrie, CW; Johnson, CD; Kingsnorth, AN; Larvin, M; Leeder, PC; McKay, C; McMahon, MJ; Neoptolemos, JP; Skaife, P; Toh, SK; Wilson, P1
Taggart, DP1
Andersson, R; Annborn, M; Böjesson, A; Lasson, A; Sun, Z; Wang, X1
Gearing, A; Gendelman, HE; Limoges, J; Persidsky, Y; Rasmussen, J; Zheng, J1
Ulrich, CD1
Curtis, L; Fatovich, D; Hitchcock, T; Morrison, C; Taylor, R1
Ashley, SW; Chandler, CF; Gloor, B; Kau, AW; Lane, JS; McFadden, DW; Reber, HA; Todd, KE1
Cevikel, MH; Kozaci, LD; Ozgün, H; Sakarya, S1
Dong, X; Ekström, U; Nilsson-Ehle, P; Xu, N; Ye, Q; Zhang, XY1
McKay, CJ1
Andersson, R; Börjesson, A; Inghammar, M; Sun, Z; Truedsson, L; Wang, X1
Andersson, K; Andersson, R; Annborn, M; Dib, M; Lasson, A; Olanders, K; Sun, Z; Wang, X1
Abu-Zidan, FM; Windsor, JA1
Andersson, R; Börjesson, A; Haraldsen, P; Lasson, A; Olanders, K; Sun, ZW1
Andersson, R; Börjesson, A; Olanders, K; Sun, ZW1
Browne, SM; Halligan, PW; Taggart, DP; Wade, DT1
Shabanov, VV1
Kraft, M; Lerch, MM; Mayerle, J; Meister, T; Simon, P1
Kuroda, Y; Takase, K; Ueda, T1
Andersson, E; Andersson, R; Börjesson, A; Leveau, P; Sun, Z; Wang, X1
Clavien, PA; Heinrich, S; Rousson, V; Schäfer, M1
Barber, A; Barcia, AM; Grendell, J; Harris, HW; Norman, J; Schell, MT; Spitzer, AL1
Mayerle, J1

Reviews

11 review(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and lexipafant

ArticleYear
Platelet-activating factor.
    Scandinavian journal of gastroenterology. Supplement, 1996, Volume: 219

    Topics: Acute Disease; Clinical Trials as Topic; Humans; Imidazoles; Leucine; Pancreatitis; Platelet Activating Factor

1996
Lexipafant (BB-882), a potent PAF antagonist in acute pancreatitis.
    Advances in experimental medicine and biology, 1996, Volume: 416

    Topics: Acute Disease; Animals; Leucine; Pancreatitis; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled

1996
The use of lexipafant in the treatment of acute pancreatitis.
    Advances in experimental medicine and biology, 1996, Volume: 416

    Topics: Acute Disease; Animals; Clinical Trials as Topic; Humans; Imidazoles; Leucine; Monocytes; Pancreatitis; Platelet Activating Factor

1996
The scientific basis of medical therapy of acute pancreatitis. Could it work, and is there a role for lexipafant?
    Gastroenterology clinics of North America, 1999, Volume: 28, Issue:3

    Topics: Acute Disease; Humans; Imidazoles; Leucine; Pancreatitis; Platelet Activating Factor; Randomized Controlled Trials as Topic

1999
Cytokines and acute pancreatitis.
    Bailliere's best practice & research. Clinical gastroenterology, 1999, Volume: 13, Issue:2

    Topics: Acute Disease; Animals; Clinical Trials as Topic; Cytokines; Humans; Imidazoles; Immunosuppression Therapy; Interleukin-1; Leucine; Leukocytes; Pancreatitis; Platelet Activating Factor; Prognosis; Tumor Necrosis Factor-alpha

1999
The possible role of platelet-activating factor antagonist therapy in the management of severe acute pancreatitis.
    Bailliere's best practice & research. Clinical gastroenterology, 1999, Volume: 13, Issue:2

    Topics: Acute Disease; Adult; Aged; Controlled Clinical Trials as Topic; Female; Humans; Imidazoles; Leucine; Male; Middle Aged; Pancreatitis; Platelet Activating Factor; Prognosis; Severity of Illness Index; Treatment Outcome

1999
Lexipafant in severe acute pancreatitis: the final word?
    Current gastroenterology reports, 2001, Volume: 3, Issue:2

    Topics: Animals; Clinical Trials as Topic; Humans; Imidazoles; Leucine; Multiple Organ Failure; Pancreatitis, Acute Necrotizing; Platelet Activating Factor; Severity of Illness Index

2001
Lexipafant and acute pancreatitis: a critical appraisal of the clinical trials.
    The European journal of surgery = Acta chirurgica, 2002, Volume: 168, Issue:4

    Topics: Acute Disease; Anti-Inflammatory Agents; Clinical Trials as Topic; Humans; Imidazoles; Leucine; Pancreatitis; Platelet Activating Factor

2002
[Conservative treatment of acute pancreatitis].
    Medizinische Klinik (Munich, Germany : 1983), 2003, Dec-15, Volume: 98, Issue:12

    Topics: Acute Disease; Adjuvants, Immunologic; Analgesics; Animals; Anti-Bacterial Agents; APACHE; C-Reactive Protein; Cholangiography; Cholangiopancreatography, Endoscopic Retrograde; Clinical Trials as Topic; Disease Models, Animal; Double-Blind Method; Enteral Nutrition; Humans; Imidazoles; Leucine; Multicenter Studies as Topic; Multiple Organ Failure; Pancreatitis; Pancreatitis, Acute Necrotizing; Placebos; Platelet Activating Factor; Prognosis; Protease Inhibitors; Randomized Controlled Trials as Topic; Retrospective Studies; Tomography, X-Ray Computed

2003
[New aspects of pharmaco-therapy for acute pancreatitis].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62, Issue:11

    Topics: Acute Disease; Animals; Blood Proteins; Clinical Trials as Topic; Drug Design; Humans; Imidazoles; Leucine; Octreotide; Pancreatitis; Platelet Activating Factor; Proglumide; Pyridines; Receptor, Cholecystokinin A; Somatostatin

2004
Evidence-based treatment of acute pancreatitis: a look at established paradigms.
    Annals of surgery, 2006, Volume: 243, Issue:2

    Topics: Acute Disease; Anti-Bacterial Agents; Antibiotic Prophylaxis; Aprotinin; Cholecystectomy; Enteral Nutrition; Evidence-Based Medicine; Gabexate; Gastrointestinal Agents; Humans; Imidazoles; Imipenem; Leucine; Meropenem; Octreotide; Pancreatitis; Pancreatitis, Acute Necrotizing; Platelet Activating Factor; Randomized Controlled Trials as Topic; Serine Proteinase Inhibitors; Sphincterotomy, Endoscopic; Thienamycins

2006

Trials

7 trial(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and lexipafant

ArticleYear
Platelet-activating factor.
    Scandinavian journal of gastroenterology. Supplement, 1996, Volume: 219

    Topics: Acute Disease; Clinical Trials as Topic; Humans; Imidazoles; Leucine; Pancreatitis; Platelet Activating Factor

1996
Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment. Neurological AIDS Research Consortium.
    Neurology, 1999, Jul-22, Volume: 53, Issue:2

    Topics: Adult; Cognition Disorders; Double-Blind Method; Female; HIV; Humans; Imidazoles; Leucine; Male; Middle Aged; Neuropsychological Tests; Platelet Activating Factor

1999
Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis.
    Critical care medicine, 2000, Volume: 28, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; APACHE; Cytokines; Double-Blind Method; Europe; Female; Hemodynamics; Humans; Immunotherapy; Infusions, Intravenous; Lactic Acid; Leucine; Male; Middle Aged; Multiple Organ Failure; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Function Tests; Sepsis; Survival Analysis

2000
Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis.
    Gut, 2001, Volume: 48, Issue:1

    Topics: Acute Disease; Adult; Aged; Biomarkers; Double-Blind Method; E-Selectin; Female; Humans; Imidazoles; Interleukin-8; Length of Stay; Leucine; Logistic Models; Male; Middle Aged; Multiple Organ Failure; Pancreatitis; Placebos; Platelet Activating Factor; Prospective Studies

2001
Effects of a platelet-activating factor antagonist on lung injury and ventilation after cardiac operation.
    The Annals of thoracic surgery, 2001, Volume: 71, Issue:1

    Topics: Adult; Aged; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Imidazoles; Leucine; Lung; Male; Middle Aged; Platelet Activating Factor; Respiratory Insufficiency

2001
Platelet-activating factor antagonism and streptokinase-induced hypotension in clinical acute myocardial infarction.
    Clinical science (London, England : 1979), 2001, Volume: 100, Issue:6

    Topics: Aged; Creatine Kinase; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypotension; Imidazoles; Leucine; Male; Middle Aged; Myocardial Infarction; Platelet Activating Factor; Streptokinase; Thrombolytic Therapy

2001
Neuroprotection during cardiac surgery: a randomised trial of a platelet activating factor antagonist.
    Heart (British Cardiac Society), 2003, Volume: 89, Issue:8

    Topics: Cognition Disorders; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Imidazoles; Leucine; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; Platelet Activating Factor

2003

Other Studies

31 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and lexipafant

ArticleYear
Modulation of lung injury by platelet-activating factor antagonism in nonhypotensive porcine endotoxemia.
    Circulatory shock, 1994, Volume: 44, Issue:3

    Topics: Animals; Escherichia coli; Female; Leucine; Lipopolysaccharides; Lung; Lung Diseases; Male; Platelet Activating Factor; Shock, Septic; Swine; Vascular Resistance

1994
Role of platelet-activating factor antagonism in haemorrhagic shock in pigs.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1995, Volume: 27, Issue:6

    Topics: Animals; Blood Pressure; Central Venous Pressure; Female; Leucine; Male; Oxygen Consumption; Platelet Activating Factor; Pulmonary Artery; Pulmonary Wedge Pressure; Shock, Hemorrhagic; Swine

1995
BB-882 is a potent antagonist of the haemodynamic changes induced by platelet-activating factor in pigs.
    Pharmacology & toxicology, 1996, Volume: 78, Issue:1

    Topics: Animals; Cardiac Output; Critical Care; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Leucine; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pulmonary Circulation; Pulmonary Wedge Pressure; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Swine; Vascular Resistance

1996
Platelet activating factor antagonism improves cardiovascular function in non-hypotensive sepsis in pigs.
    The European journal of surgery = Acta chirurgica, 1996, Volume: 162, Issue:6

    Topics: Animals; Blood Pressure; Cardiac Output; Endotoxemia; Escherichia coli Infections; Heart Rate; Hemodynamics; Leucine; Platelet Activating Factor; Sepsis; Stroke Volume; Swine

1996
Lung injury in the microembolic model of acute pancreatitis and amelioration by lexipafant (BB-882), a platelet-activating factor antagonist.
    Pancreas, 1996, Volume: 13, Issue:2

    Topics: Acute Disease; Animals; Capillary Permeability; Coloring Agents; Evans Blue; Kidney; Leucine; Lung; Lung Diseases; Male; Pancreatitis; Platelet Activating Factor; Rats; Rats, Wistar

1996
Role of platelet-activating factor antagonism in posthemorrhage septic shock in pigs.
    The Journal of trauma, 1996, Volume: 41, Issue:4

    Topics: Animals; Body Temperature; Cardiac Output; Heart Rate; Hemodynamics; Leucine; Platelet Activating Factor; Shock, Hemorrhagic; Shock, Septic; Swine; Vascular Resistance

1996
Role of platelet-activating factor on cardiovascular dysfunction in postischemic shock in pigs.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1997, Volume: 29, Issue:2

    Topics: Animals; Hemodynamics; Heparin; Ischemia; Leucine; Platelet Activating Factor; Shock; Swine

1997
Lexipafant inhibits platelet activating factor enhanced neutrophil functions.
    The Journal of surgical research, 1997, Volume: 69, Issue:2

    Topics: Dose-Response Relationship, Drug; Free Radicals; Humans; Imidazoles; Leucine; Leukocyte Elastase; Macrophage-1 Antigen; Neutrophils; Platelet Activating Factor; Respiratory Burst; Superoxides; Temperature

1997
Effect of endotoxin and platelet-activating factor on rat vascular permeability: role of vasoactive mediators.
    Journal of lipid mediators and cell signalling, 1997, Volume: 17, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Capillary Permeability; Dose-Response Relationship, Drug; Exudates and Transudates; Imidazoles; Indomethacin; Leucine; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Piperazines; Platelet Activating Factor; Pyrazoles; Rats; Rats, Sprague-Dawley

1997
Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock.
    Surgery, 1998, Volume: 123, Issue:2

    Topics: Animals; Fluid Therapy; Imidazoles; Leucine; Platelet Activating Factor; Resuscitation; Shock; Swine; Wounds and Injuries

1998
The platelet-activating factor antagonist BB-882 does not improve tissue oxygen extraction in endotoxic shock.
    Journal of critical care, 1998, Volume: 13, Issue:2

    Topics: Animals; Cardiac Output; Cardiac Tamponade; Dogs; Endotoxins; Escherichia coli; Female; Hemodynamics; Leucine; Male; Myocardial Contraction; Oxygen; Oxygen Consumption; Platelet Activating Factor; Pulmonary Wedge Pressure; Shock, Septic

1998
Effect of a platelet-activating factor antagonist on pancreatitis-associated gut barrier dysfunction in rats.
    Pancreas, 1998, Volume: 17, Issue:2

    Topics: Acute Disease; Animals; Bacterial Translocation; Calcium; Capillary Permeability; Endothelium, Vascular; Enterobacteriaceae; Hematocrit; Imidazoles; Intestinal Mucosa; Leucine; Lipase; Male; Pancreas; Pancreatitis; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Taurodeoxycholic Acid

1998
Hope or hype for lexipafant?
    Nature, 1998, Oct-01, Volume: 395, Issue:6701

    Topics: Clinical Trials as Topic; Humans; Imidazoles; Leucine; Pancreatitis; Platelet Activating Factor

1998
Inhibition of platelet-activating factor, intercellular adhesion molecule 1 and platelet endothelial cell adhesion molecule 1 reduces experimental pancreatitis-associated gut endothelial barrier dysfunction.
    The British journal of surgery, 1999, Volume: 86, Issue:3

    Topics: Animals; Capillaries; Endothelium, Vascular; Gastrointestinal Diseases; Imidazoles; Intercellular Adhesion Molecule-1; Interleukins; Leucine; Leukocytes; Lymphocyte Activation; Male; Pancreatitis; Platelet Activating Factor; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Sprague-Dawley

1999
Treatment with lexipafant ameliorates the severity of pancreatic microvascular endothelial barrier dysfunction in rats with acute hemorrhagic pancreatitis.
    International journal of pancreatology : official journal of the International Association of Pancreatology, 1999, Volume: 25, Issue:1

    Topics: Acute Disease; Animals; Body Water; Capillary Permeability; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Gastrointestinal Hemorrhage; Imidazoles; Interleukin-1; Interleukin-6; Leucine; Male; Microcirculation; Pancreatitis; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Serum Albumin; Time Factors

1999
The effect of lexipafant on bacterial translocation in acute necrotizing pancreatitis in rats.
    The American surgeon, 1999, Volume: 65, Issue:7

    Topics: Amylases; Animals; Bacterial Translocation; Imidazoles; Leucine; Lymph Nodes; Male; Pancreatitis, Acute Necrotizing; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

1999
Beneficial effects of lexipafant, a PAF antagonist on gut barrier dysfunction caused by intestinal ischemia and reperfusion in rats.
    Digestive surgery, 2000, Volume: 17, Issue:1

    Topics: Animals; Endothelium; Epithelium; Imidazoles; Intestinal Mucosa; Intestines; Leucine; Male; Permeability; Platelet Activating Factor; Premedication; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors

2000
Effects of inhibition of PAF, ICAM-1 and PECAM-1 on gut barrier failure caused by intestinal ischemia and reperfusion.
    Scandinavian journal of gastroenterology, 2001, Volume: 36, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Imidazoles; Intercellular Adhesion Molecule-1; Intestine, Small; Leucine; Leukocytes; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2001
Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis.
    Journal of neuroimmunology, 2001, Mar-01, Volume: 114, Issue:1-2

    Topics: AIDS Dementia Complex; Animals; Benzyl Compounds; Cell Survival; Dexamethasone; Disease Models, Animal; Drug Combinations; Gliosis; HIV-1; Humans; In Vitro Techniques; Interleukin-1; Interleukin-8; Leucine; Macrophages; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, SCID; Microglia; Neurons; Pentoxifylline; Platelet Activating Factor; Protease Inhibitors; Succinates; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2001
Platelet activating factor antagonism reduces the systemic inflammatory response in a murine model of acute pancreatitis.
    The Journal of surgical research, 2001, Volume: 99, Issue:2

    Topics: Acute Disease; Amylases; Animals; Disease Models, Animal; Female; Imidazoles; Interleukin-1; Leucine; Lung; Mice; Pancreatitis; Peroxidase; Platelet Activating Factor; Tumor Necrosis Factor-alpha

2001
Lexipafant inhibits postsurgical adhesion formation.
    The Journal of surgical research, 2002, Volume: 103, Issue:2

    Topics: Animals; Female; Hydroxyproline; Imidazoles; Interleukin-6; Leucine; Peritoneal Diseases; Platelet Activating Factor; Postoperative Complications; Rats; Rats, Wistar; Tissue Adhesions; Uterus; Wound Healing

2002
Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells.
    Biochemical and biophysical research communications, 2002, Apr-12, Volume: 292, Issue:4

    Topics: Apolipoprotein A-I; Apolipoproteins; Apolipoproteins B; Apolipoproteins E; Apolipoproteins M; Dose-Response Relationship, Drug; Gene Expression; Hepatoblastoma; Humans; Imidazoles; Interleukin-1; Leucine; Lipocalins; Liver Neoplasms; Platelet Activating Factor; RNA, Messenger; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2002
Recent developments in the management of acute pancreatitis.
    Digestive surgery, 2002, Volume: 19, Issue:2

    Topics: Acute Disease; Antibiotic Prophylaxis; Cholangiopancreatography, Endoscopic Retrograde; Drainage; Humans; Imidazoles; Laparoscopy; Leucine; Pancreatitis; Platelet Activating Factor

2002
Early treatment with lexipafant, a platelet-activating factor-receptor antagonist, is not sufficient to prevent pulmonary endothelial damage after intestinal ischaemia and reperfusion in rats.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2002, Volume: 34, Issue:3

    Topics: Animals; Endothelium, Vascular; Imidazoles; Interleukin-1; Leucine; Lung; Male; Peroxidase; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Treatment Failure

2002
Effective treatment of gut barrier dysfunction using an antioxidant, a PAF inhibitor, and monoclonal antibodies against the adhesion molecule PECAM-1.
    The Journal of surgical research, 2002, Jun-15, Volume: 105, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Antioxidants; Body Water; Capillary Permeability; Imidazoles; Interleukin-1; Intestinal Mucosa; Intestine, Small; Leucine; Leukocytes; Male; Peroxidase; Platelet Activating Factor; Platelet Endothelial Cell Adhesion Molecule-1; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Serum Albumin

2002
Multimodal management - of value in fulminant acute pancreatitis?
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2003, Volume: 3, Issue:1

    Topics: Acetylcysteine; Acute Disease; Animals; Antibodies, Monoclonal; Capillary Permeability; Drug Therapy, Combination; Free Radical Scavengers; Imidazoles; Leucine; Male; Pancreatitis; Platelet Activating Factor; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Sprague-Dawley

2003
Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats.
    Scandinavian journal of gastroenterology, 2003, Volume: 38, Issue:6

    Topics: Acetylcysteine; Animals; Cytoprotection; Free Radical Scavengers; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-1; Intestinal Mucosa; Intestines; Ischemia; Leucine; Male; Neutrophil Infiltration; Permeability; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2003
[Cytokines and other signal molecules in the pathogenesis of acute pancreatitis].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 2003, Issue:9

    Topics: Acute Disease; Acute-Phase Proteins; Animals; Cell Adhesion Molecules; Chemokines; Cytokines; Free Radicals; Humans; Imidazoles; Interleukins; Leucine; Mice; Multiple Organ Failure; Pancreas; Pancreatitis; Platelet Activating Factor; Rabbits; Rats; Selectins; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha

2003
Severity of pancreatitis-associated gut barrier dysfunction is reduced following treatment with the PAF inhibitor lexipafant.
    Biochemical pharmacology, 2005, May-01, Volume: 69, Issue:9

    Topics: Acute Disease; Animals; Capillary Permeability; Chromium Radioisotopes; Endothelium, Vascular; Humans; Imidazoles; Interleukin-1; Interleukin-6; Intestinal Mucosa; Intestine, Small; Iodine Radioisotopes; Leucine; Leukocytes; Male; Pancreatitis; Peroxidase; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Serum Albumin; Taurodeoxycholic Acid

2005
Applying Ockham's razor to pancreatitis prognostication: a four-variable predictive model.
    Annals of surgery, 2006, Volume: 243, Issue:3

    Topics: APACHE; Female; Follow-Up Studies; Humans; Imidazoles; Leucine; Male; Middle Aged; Models, Theoretical; Pancreatitis, Acute Necrotizing; Platelet Activating Factor; Prognosis; Randomized Controlled Trials as Topic; ROC Curve; Severity of Illness Index; Survival Rate

2006
A novel role for leucocytes in determining the severity of acute pancreatitis.
    Gut, 2009, Volume: 58, Issue:11

    Topics: Acute Disease; Animals; Biomarkers; Capillaries; Humans; Imidazoles; Inflammation Mediators; Leucine; Leukocytes; Mice; Pancreatitis; Platelet Activating Factor; Prognosis; Severity of Illness Index

2009