1-hexadecyl-2-acetyl-glycero-3-phosphocholine and leucine

1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with leucine in 56 studies

Compound Research Comparison

Studies (1-hexadecyl-2-acetyl-glycero-3-phosphocholine)	Trials (1-hexadecyl-2-acetyl-glycero-3-phosphocholine)	Recent Studies (post-2010) (1-hexadecyl-2-acetyl-glycero-3-phosphocholine)	Studies (leucine)	Trials (leucine)	Recent Studies (post-2010) (leucine)
9,156	187	552	28,515	744	4,178

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	29 (51.79)	18.2507
2000's	27 (48.21)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dahinden, CA; de Weck, AL; Wirthmueller, U	1
Fujii, J; Hiraishi, S; Ishii, H; Kazama, M; Kuboki, M	1
Alonso, A; Bosca, L; Crespo, MS; Garcia Rodriguez, MC; Steil, AA	1
Abu-Zidan, FM; Lennquist, S; Walther, S	5
Gonzalez-Sarmiento, R; López-Novoa, JM; Rodriguez-Barbero, A; Rodriguez-Lopez, AM	1
Bryant, CM; Endemann, G; Feng, Y; Hamilton, GS; Liu, DY; Mewshaw, RE; Perumattam, J	1
Abu-Zidan, FM; Walther, S	1
Galloway, SW; Kingsnorth, AN	1
Kingsnorth, AN	1
Curtis, LD	1
Baxter, JN; Curran, FJ; Imrie, CW; McKay, C; Sharples, CE; Young, CA	1
Colvin, SB; Eng, K; Galloway, AC; Grossi, EA; Jacobs, CE; Marcus, SG; Schwartz, DS; Schwartz, JD; Shamamian, P; Steiner, F; Tayyarah, M	1
Balsa, D; Ferrando, R; Forn, J; Garcia-Rafanell, J; Giral, M; Merlos, M	1
Alp, MS; Aspey, BS; Harrison, MJ; Patel, Y	1
Abu-Zidan, FM	2
Smail, N; Spapen, H; Verhaeghe, V; Vincent, JL; Zhang, H	1
Andersson, R; Deng, X; Ihse, I; Soltesz, V; Sun, Z; Wang, X	1
Andersson, R; Börjesson, A; Sun, Z; Wang, X	1
Aldman, M; Andersson, R; Börjesson, A; Deng, X; Haraldsen, P; Leveau, P; Sun, Z; Wang, X	1
Bewsey, K; Djuricin, G; Gattuso, P; Liu, Q; Nathan, C; Prinz, RA; Rossi, H; Weinstein, RA	1
Epstein, LG; Kieburtz, K; Marder, K; McArthur, JC; McDermott, MP; Sacktor, N; Schifitto, G; Small, S	1
Imrie, CW; McKay, CJ	2
Andersson, R; Börjesson, A; Deng, X; Lasson, A; Soltesz, V; Sun, Z; Wang, X	1
Bakker, J; Curtis, L; Spapen, H; Vincent, JL; Webster, NR	1
Brady, M; Christmas, S; Neoptolemos, J; Slavin, J; Sutton, R	1
Buripakdi, D; Carroll, RC; Karlstad, MD	1
Curtis, LD; Imrie, CW; Johnson, CD; Kingsnorth, AN; Larvin, M; Leeder, PC; McKay, C; McMahon, MJ; Neoptolemos, JP; Skaife, P; Toh, SK; Wilson, P	1
Taggart, DP	1
Andersson, R; Annborn, M; Böjesson, A; Lasson, A; Sun, Z; Wang, X	1
Gearing, A; Gendelman, HE; Limoges, J; Persidsky, Y; Rasmussen, J; Zheng, J	1
Ulrich, CD	1
Curtis, L; Fatovich, D; Hitchcock, T; Morrison, C; Taylor, R	1
Ashley, SW; Chandler, CF; Gloor, B; Kau, AW; Lane, JS; McFadden, DW; Reber, HA; Todd, KE	1
Cevikel, MH; Kozaci, LD; Ozgün, H; Sakarya, S	1
Dong, X; Ekström, U; Nilsson-Ehle, P; Xu, N; Ye, Q; Zhang, XY	1
McKay, CJ	1
Andersson, R; Börjesson, A; Inghammar, M; Sun, Z; Truedsson, L; Wang, X	1
Andersson, K; Andersson, R; Annborn, M; Dib, M; Lasson, A; Olanders, K; Sun, Z; Wang, X	1
Abu-Zidan, FM; Windsor, JA	1
Andersson, R; Börjesson, A; Haraldsen, P; Lasson, A; Olanders, K; Sun, ZW	1
Andersson, R; Börjesson, A; Olanders, K; Sun, ZW	1
Browne, SM; Halligan, PW; Taggart, DP; Wade, DT	1
Shabanov, VV	1
Kraft, M; Lerch, MM; Mayerle, J; Meister, T; Simon, P	1
Kuroda, Y; Takase, K; Ueda, T	1
Andersson, E; Andersson, R; Börjesson, A; Leveau, P; Sun, Z; Wang, X	1
Clavien, PA; Heinrich, S; Rousson, V; Schäfer, M	1
Barber, A; Barcia, AM; Grendell, J; Harris, HW; Norman, J; Schell, MT; Spitzer, AL	1
Baker, KE; Curtis, MJ; Whittaker, M; Wood, LM	1
Mayerle, J	1

Reviews

12 review(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and leucine

Article	Year
Platelet-activating factor. Scandinavian journal of gastroenterology. Supplement, 1996, Volume: 219 Topics: Acute Disease; Clinical Trials as Topic; Humans; Imidazoles; Leucine; Pancreatitis; Platelet Activating Factor	1996
Lexipafant (BB-882), a potent PAF antagonist in acute pancreatitis. Advances in experimental medicine and biology, 1996, Volume: 416 Topics: Acute Disease; Animals; Leucine; Pancreatitis; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled	1996
The use of lexipafant in the treatment of acute pancreatitis. Advances in experimental medicine and biology, 1996, Volume: 416 Topics: Acute Disease; Animals; Clinical Trials as Topic; Humans; Imidazoles; Leucine; Monocytes; Pancreatitis; Platelet Activating Factor	1996
Effects of combined glutamate and platelet-activating factor inhibition on the outcome of focal cerebral ischaemia - an initial screening study. Metabolic brain disease, 1997, Volume: 12, Issue:3 Topics: Animals; Brain Ischemia; Cerebral Infarction; Drug Combinations; Glutamic Acid; Leucine; Male; Movement Disorders; Neuroprotective Agents; Periaqueductal Gray; Piperazines; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sodium Channel Blockers; Time Factors	1997
The scientific basis of medical therapy of acute pancreatitis. Could it work, and is there a role for lexipafant? Gastroenterology clinics of North America, 1999, Volume: 28, Issue:3 Topics: Acute Disease; Humans; Imidazoles; Leucine; Pancreatitis; Platelet Activating Factor; Randomized Controlled Trials as Topic	1999
Cytokines and acute pancreatitis. Bailliere's best practice & research. Clinical gastroenterology, 1999, Volume: 13, Issue:2 Topics: Acute Disease; Animals; Clinical Trials as Topic; Cytokines; Humans; Imidazoles; Immunosuppression Therapy; Interleukin-1; Leucine; Leukocytes; Pancreatitis; Platelet Activating Factor; Prognosis; Tumor Necrosis Factor-alpha	1999
The possible role of platelet-activating factor antagonist therapy in the management of severe acute pancreatitis. Bailliere's best practice & research. Clinical gastroenterology, 1999, Volume: 13, Issue:2 Topics: Acute Disease; Adult; Aged; Controlled Clinical Trials as Topic; Female; Humans; Imidazoles; Leucine; Male; Middle Aged; Pancreatitis; Platelet Activating Factor; Prognosis; Severity of Illness Index; Treatment Outcome	1999
Lexipafant in severe acute pancreatitis: the final word? Current gastroenterology reports, 2001, Volume: 3, Issue:2 Topics: Animals; Clinical Trials as Topic; Humans; Imidazoles; Leucine; Multiple Organ Failure; Pancreatitis, Acute Necrotizing; Platelet Activating Factor; Severity of Illness Index	2001
Lexipafant and acute pancreatitis: a critical appraisal of the clinical trials. The European journal of surgery = Acta chirurgica, 2002, Volume: 168, Issue:4 Topics: Acute Disease; Anti-Inflammatory Agents; Clinical Trials as Topic; Humans; Imidazoles; Leucine; Pancreatitis; Platelet Activating Factor	2002
[Conservative treatment of acute pancreatitis]. Medizinische Klinik (Munich, Germany : 1983), 2003, Dec-15, Volume: 98, Issue:12 Topics: Acute Disease; Adjuvants, Immunologic; Analgesics; Animals; Anti-Bacterial Agents; APACHE; C-Reactive Protein; Cholangiography; Cholangiopancreatography, Endoscopic Retrograde; Clinical Trials as Topic; Disease Models, Animal; Double-Blind Method; Enteral Nutrition; Humans; Imidazoles; Leucine; Multicenter Studies as Topic; Multiple Organ Failure; Pancreatitis; Pancreatitis, Acute Necrotizing; Placebos; Platelet Activating Factor; Prognosis; Protease Inhibitors; Randomized Controlled Trials as Topic; Retrospective Studies; Tomography, X-Ray Computed	2003
[New aspects of pharmaco-therapy for acute pancreatitis]. Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62, Issue:11 Topics: Acute Disease; Animals; Blood Proteins; Clinical Trials as Topic; Drug Design; Humans; Imidazoles; Leucine; Octreotide; Pancreatitis; Platelet Activating Factor; Proglumide; Pyridines; Receptor, Cholecystokinin A; Somatostatin	2004
Evidence-based treatment of acute pancreatitis: a look at established paradigms. Annals of surgery, 2006, Volume: 243, Issue:2 Topics: Acute Disease; Anti-Bacterial Agents; Antibiotic Prophylaxis; Aprotinin; Cholecystectomy; Enteral Nutrition; Evidence-Based Medicine; Gabexate; Gastrointestinal Agents; Humans; Imidazoles; Imipenem; Leucine; Meropenem; Octreotide; Pancreatitis; Pancreatitis, Acute Necrotizing; Platelet Activating Factor; Randomized Controlled Trials as Topic; Serine Proteinase Inhibitors; Sphincterotomy, Endoscopic; Thienamycins	2006

Trials

7 trial(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and leucine

Article	Year
Platelet-activating factor. Scandinavian journal of gastroenterology. Supplement, 1996, Volume: 219 Topics: Acute Disease; Clinical Trials as Topic; Humans; Imidazoles; Leucine; Pancreatitis; Platelet Activating Factor	1996
Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment. Neurological AIDS Research Consortium. Neurology, 1999, Jul-22, Volume: 53, Issue:2 Topics: Adult; Cognition Disorders; Double-Blind Method; Female; HIV; Humans; Imidazoles; Leucine; Male; Middle Aged; Neuropsychological Tests; Platelet Activating Factor	1999
Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis. Critical care medicine, 2000, Volume: 28, Issue:3 Topics: Adult; Aged; Aged, 80 and over; APACHE; Cytokines; Double-Blind Method; Europe; Female; Hemodynamics; Humans; Immunotherapy; Infusions, Intravenous; Lactic Acid; Leucine; Male; Middle Aged; Multiple Organ Failure; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Function Tests; Sepsis; Survival Analysis	2000
Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis. Gut, 2001, Volume: 48, Issue:1 Topics: Acute Disease; Adult; Aged; Biomarkers; Double-Blind Method; E-Selectin; Female; Humans; Imidazoles; Interleukin-8; Length of Stay; Leucine; Logistic Models; Male; Middle Aged; Multiple Organ Failure; Pancreatitis; Placebos; Platelet Activating Factor; Prospective Studies	2001
Effects of a platelet-activating factor antagonist on lung injury and ventilation after cardiac operation. The Annals of thoracic surgery, 2001, Volume: 71, Issue:1 Topics: Adult; Aged; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Imidazoles; Leucine; Lung; Male; Middle Aged; Platelet Activating Factor; Respiratory Insufficiency	2001
Platelet-activating factor antagonism and streptokinase-induced hypotension in clinical acute myocardial infarction. Clinical science (London, England : 1979), 2001, Volume: 100, Issue:6 Topics: Aged; Creatine Kinase; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypotension; Imidazoles; Leucine; Male; Middle Aged; Myocardial Infarction; Platelet Activating Factor; Streptokinase; Thrombolytic Therapy	2001
Neuroprotection during cardiac surgery: a randomised trial of a platelet activating factor antagonist. Heart (British Cardiac Society), 2003, Volume: 89, Issue:8 Topics: Cognition Disorders; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Imidazoles; Leucine; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; Platelet Activating Factor	2003

Other Studies

38 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and leucine

Article	Year
Studies on the mechanism of platelet-activating factor production in GM-CSF primed neutrophils: involvement of protein synthesis and phospholipase A2 activation. Biochemical and biophysical research communications, 1990, Jul-31, Volume: 170, Issue:2 Topics: Arachidonate 5-Lipoxygenase; Arachidonate Lipoxygenases; Colony-Stimulating Factors; Cycloheximide; Dactinomycin; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; Leucine; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Uridine	1990
Thiolprotease inhibitor, EST, can inhibit thrombin-induced platelet activation. Thrombosis research, 1990, Mar-15, Volume: 57, Issue:6 Topics: Adult; Blood Platelets; Calpain; Cysteine Proteinase Inhibitors; Enzyme Activation; Humans; Inositol Phosphates; Leucine; Phosphatidylinositols; Phosphorylation; Platelet Activating Factor; Platelet Activation; Platelet Aggregation Inhibitors; Serotonin; Thrombin; Type C Phospholipases	1990
Platelet-activating factor: the effector of protein-rich plasma extravasation and nitric oxide synthase induction in rat immune complex peritonitis. British journal of pharmacology, 1995, Volume: 114, Issue:4 Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Antibody Formation; Arginine; Arthus Reaction; Blotting, Northern; Cells, Cultured; Enzyme Induction; Extravasation of Diagnostic and Therapeutic Materials; Leucine; Male; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peritoneal Cavity; Peritonitis; Phagocytes; Piperazines; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Specific Pathogen-Free Organisms	1995
Modulation of lung injury by platelet-activating factor antagonism in nonhypotensive porcine endotoxemia. Circulatory shock, 1994, Volume: 44, Issue:3 Topics: Animals; Escherichia coli; Female; Leucine; Lipopolysaccharides; Lung; Lung Diseases; Male; Platelet Activating Factor; Shock, Septic; Swine; Vascular Resistance	1994
Gentamicin activates rat mesangial cells. A role for platelet activating factor. Kidney international, 1995, Volume: 47, Issue:5 Topics: Alprazolam; Animals; Base Sequence; Calcium; Cell Division; Cells, Cultured; Diterpenes; Genes, fos; Gentamicins; Ginkgolides; Glomerular Filtration Rate; Glomerular Mesangium; Lactones; Leucine; Molecular Sequence Data; Platelet Activating Factor; Rats; Rats, Wistar; RNA, Messenger	1995
Role of platelet-activating factor antagonism in haemorrhagic shock in pigs. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1995, Volume: 27, Issue:6 Topics: Animals; Blood Pressure; Central Venous Pressure; Female; Leucine; Male; Oxygen Consumption; Platelet Activating Factor; Pulmonary Artery; Pulmonary Wedge Pressure; Shock, Hemorrhagic; Swine	1995
Novel anti-inflammatory compounds prevent CD11b/CD18, alpha M beta 2 (Mac-1)-dependent neutrophil adhesion without blocking activation-induced changes in Mac-1. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:1 Topics: Amino Acid Sequence; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Calcimycin; Cell Adhesion; Epitopes; Flow Cytometry; Humans; Ionophores; Leucine; Macrophage-1 Antigen; Molecular Sequence Data; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Tumor Necrosis Factor-alpha; Up-Regulation	1996
BB-882 is a potent antagonist of the haemodynamic changes induced by platelet-activating factor in pigs. Pharmacology & toxicology, 1996, Volume: 78, Issue:1 Topics: Animals; Cardiac Output; Critical Care; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Leucine; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pulmonary Circulation; Pulmonary Wedge Pressure; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Swine; Vascular Resistance	1996
Platelet activating factor antagonism improves cardiovascular function in non-hypotensive sepsis in pigs. The European journal of surgery = Acta chirurgica, 1996, Volume: 162, Issue:6 Topics: Animals; Blood Pressure; Cardiac Output; Endotoxemia; Escherichia coli Infections; Heart Rate; Hemodynamics; Leucine; Platelet Activating Factor; Sepsis; Stroke Volume; Swine	1996
Lung injury in the microembolic model of acute pancreatitis and amelioration by lexipafant (BB-882), a platelet-activating factor antagonist. Pancreas, 1996, Volume: 13, Issue:2 Topics: Acute Disease; Animals; Capillary Permeability; Coloring Agents; Evans Blue; Kidney; Leucine; Lung; Lung Diseases; Male; Pancreatitis; Platelet Activating Factor; Rats; Rats, Wistar	1996
Role of platelet-activating factor antagonism in posthemorrhage septic shock in pigs. The Journal of trauma, 1996, Volume: 41, Issue:4 Topics: Animals; Body Temperature; Cardiac Output; Heart Rate; Hemodynamics; Leucine; Platelet Activating Factor; Shock, Hemorrhagic; Shock, Septic; Swine; Vascular Resistance	1996
Role of platelet-activating factor on cardiovascular dysfunction in postischemic shock in pigs. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1997, Volume: 29, Issue:2 Topics: Animals; Hemodynamics; Heparin; Ischemia; Leucine; Platelet Activating Factor; Shock; Swine	1997
Lexipafant inhibits platelet activating factor enhanced neutrophil functions. The Journal of surgical research, 1997, Volume: 69, Issue:2 Topics: Dose-Response Relationship, Drug; Free Radicals; Humans; Imidazoles; Leucine; Leukocyte Elastase; Macrophage-1 Antigen; Neutrophils; Platelet Activating Factor; Respiratory Burst; Superoxides; Temperature	1997
Effect of endotoxin and platelet-activating factor on rat vascular permeability: role of vasoactive mediators. Journal of lipid mediators and cell signalling, 1997, Volume: 17, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Capillary Permeability; Dose-Response Relationship, Drug; Exudates and Transudates; Imidazoles; Indomethacin; Leucine; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Piperazines; Platelet Activating Factor; Pyrazoles; Rats; Rats, Sprague-Dawley	1997
Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock. Surgery, 1998, Volume: 123, Issue:2 Topics: Animals; Fluid Therapy; Imidazoles; Leucine; Platelet Activating Factor; Resuscitation; Shock; Swine; Wounds and Injuries	1998
The platelet-activating factor antagonist BB-882 does not improve tissue oxygen extraction in endotoxic shock. Journal of critical care, 1998, Volume: 13, Issue:2 Topics: Animals; Cardiac Output; Cardiac Tamponade; Dogs; Endotoxins; Escherichia coli; Female; Hemodynamics; Leucine; Male; Myocardial Contraction; Oxygen; Oxygen Consumption; Platelet Activating Factor; Pulmonary Wedge Pressure; Shock, Septic	1998
Effect of a platelet-activating factor antagonist on pancreatitis-associated gut barrier dysfunction in rats. Pancreas, 1998, Volume: 17, Issue:2 Topics: Acute Disease; Animals; Bacterial Translocation; Calcium; Capillary Permeability; Endothelium, Vascular; Enterobacteriaceae; Hematocrit; Imidazoles; Intestinal Mucosa; Leucine; Lipase; Male; Pancreas; Pancreatitis; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Taurodeoxycholic Acid	1998
Hope or hype for lexipafant? Nature, 1998, Oct-01, Volume: 395, Issue:6701 Topics: Clinical Trials as Topic; Humans; Imidazoles; Leucine; Pancreatitis; Platelet Activating Factor	1998
Inhibition of platelet-activating factor, intercellular adhesion molecule 1 and platelet endothelial cell adhesion molecule 1 reduces experimental pancreatitis-associated gut endothelial barrier dysfunction. The British journal of surgery, 1999, Volume: 86, Issue:3 Topics: Animals; Capillaries; Endothelium, Vascular; Gastrointestinal Diseases; Imidazoles; Intercellular Adhesion Molecule-1; Interleukins; Leucine; Leukocytes; Lymphocyte Activation; Male; Pancreatitis; Platelet Activating Factor; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Sprague-Dawley	1999
Treatment with lexipafant ameliorates the severity of pancreatic microvascular endothelial barrier dysfunction in rats with acute hemorrhagic pancreatitis. International journal of pancreatology : official journal of the International Association of Pancreatology, 1999, Volume: 25, Issue:1 Topics: Acute Disease; Animals; Body Water; Capillary Permeability; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Gastrointestinal Hemorrhage; Imidazoles; Interleukin-1; Interleukin-6; Leucine; Male; Microcirculation; Pancreatitis; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Serum Albumin; Time Factors	1999
The effect of lexipafant on bacterial translocation in acute necrotizing pancreatitis in rats. The American surgeon, 1999, Volume: 65, Issue:7 Topics: Amylases; Animals; Bacterial Translocation; Imidazoles; Leucine; Lymph Nodes; Male; Pancreatitis, Acute Necrotizing; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha	1999
Beneficial effects of lexipafant, a PAF antagonist on gut barrier dysfunction caused by intestinal ischemia and reperfusion in rats. Digestive surgery, 2000, Volume: 17, Issue:1 Topics: Animals; Endothelium; Epithelium; Imidazoles; Intestinal Mucosa; Intestines; Leucine; Male; Permeability; Platelet Activating Factor; Premedication; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors	2000
Platelet-activating factor (PAF)-induced decreases in whole-body and skeletal muscle protein synthesis. Shock (Augusta, Ga.), 2000, Volume: 14, Issue:4 Topics: Amino Acids; Animals; Carbohydrate Metabolism; Kinetics; Leucine; Liver; Male; Muscle Proteins; Muscle, Skeletal; Myofibrils; Platelet Activating Factor; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; RNA; Shock, Septic	2000
Effects of inhibition of PAF, ICAM-1 and PECAM-1 on gut barrier failure caused by intestinal ischemia and reperfusion. Scandinavian journal of gastroenterology, 2001, Volume: 36, Issue:1 Topics: Animals; Antibodies, Monoclonal; Imidazoles; Intercellular Adhesion Molecule-1; Intestine, Small; Leucine; Leukocytes; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Sprague-Dawley; Reperfusion Injury	2001
Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis. Journal of neuroimmunology, 2001, Mar-01, Volume: 114, Issue:1-2 Topics: AIDS Dementia Complex; Animals; Benzyl Compounds; Cell Survival; Dexamethasone; Disease Models, Animal; Drug Combinations; Gliosis; HIV-1; Humans; In Vitro Techniques; Interleukin-1; Interleukin-8; Leucine; Macrophages; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, SCID; Microglia; Neurons; Pentoxifylline; Platelet Activating Factor; Protease Inhibitors; Succinates; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha	2001
Platelet activating factor antagonism reduces the systemic inflammatory response in a murine model of acute pancreatitis. The Journal of surgical research, 2001, Volume: 99, Issue:2 Topics: Acute Disease; Amylases; Animals; Disease Models, Animal; Female; Imidazoles; Interleukin-1; Leucine; Lung; Mice; Pancreatitis; Peroxidase; Platelet Activating Factor; Tumor Necrosis Factor-alpha	2001
Lexipafant inhibits postsurgical adhesion formation. The Journal of surgical research, 2002, Volume: 103, Issue:2 Topics: Animals; Female; Hydroxyproline; Imidazoles; Interleukin-6; Leucine; Peritoneal Diseases; Platelet Activating Factor; Postoperative Complications; Rats; Rats, Wistar; Tissue Adhesions; Uterus; Wound Healing	2002
Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells. Biochemical and biophysical research communications, 2002, Apr-12, Volume: 292, Issue:4 Topics: Apolipoprotein A-I; Apolipoproteins; Apolipoproteins B; Apolipoproteins E; Apolipoproteins M; Dose-Response Relationship, Drug; Gene Expression; Hepatoblastoma; Humans; Imidazoles; Interleukin-1; Leucine; Lipocalins; Liver Neoplasms; Platelet Activating Factor; RNA, Messenger; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	2002
Recent developments in the management of acute pancreatitis. Digestive surgery, 2002, Volume: 19, Issue:2 Topics: Acute Disease; Antibiotic Prophylaxis; Cholangiopancreatography, Endoscopic Retrograde; Drainage; Humans; Imidazoles; Laparoscopy; Leucine; Pancreatitis; Platelet Activating Factor	2002
Early treatment with lexipafant, a platelet-activating factor-receptor antagonist, is not sufficient to prevent pulmonary endothelial damage after intestinal ischaemia and reperfusion in rats. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2002, Volume: 34, Issue:3 Topics: Animals; Endothelium, Vascular; Imidazoles; Interleukin-1; Leucine; Lung; Male; Peroxidase; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Treatment Failure	2002
Effective treatment of gut barrier dysfunction using an antioxidant, a PAF inhibitor, and monoclonal antibodies against the adhesion molecule PECAM-1. The Journal of surgical research, 2002, Jun-15, Volume: 105, Issue:2 Topics: Animals; Antibodies, Monoclonal; Antioxidants; Body Water; Capillary Permeability; Imidazoles; Interleukin-1; Intestinal Mucosa; Intestine, Small; Leucine; Leukocytes; Male; Peroxidase; Platelet Activating Factor; Platelet Endothelial Cell Adhesion Molecule-1; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Serum Albumin	2002
Multimodal management - of value in fulminant acute pancreatitis? Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2003, Volume: 3, Issue:1 Topics: Acetylcysteine; Acute Disease; Animals; Antibodies, Monoclonal; Capillary Permeability; Drug Therapy, Combination; Free Radical Scavengers; Imidazoles; Leucine; Male; Pancreatitis; Platelet Activating Factor; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Sprague-Dawley	2003
Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats. Scandinavian journal of gastroenterology, 2003, Volume: 38, Issue:6 Topics: Acetylcysteine; Animals; Cytoprotection; Free Radical Scavengers; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-1; Intestinal Mucosa; Intestines; Ischemia; Leucine; Male; Neutrophil Infiltration; Permeability; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reperfusion Injury	2003
[Cytokines and other signal molecules in the pathogenesis of acute pancreatitis]. Vestnik Rossiiskoi akademii meditsinskikh nauk, 2003, Issue:9 Topics: Acute Disease; Acute-Phase Proteins; Animals; Cell Adhesion Molecules; Chemokines; Cytokines; Free Radicals; Humans; Imidazoles; Interleukins; Leucine; Mice; Multiple Organ Failure; Pancreas; Pancreatitis; Platelet Activating Factor; Rabbits; Rats; Selectins; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha	2003
Severity of pancreatitis-associated gut barrier dysfunction is reduced following treatment with the PAF inhibitor lexipafant. Biochemical pharmacology, 2005, May-01, Volume: 69, Issue:9 Topics: Acute Disease; Animals; Capillary Permeability; Chromium Radioisotopes; Endothelium, Vascular; Humans; Imidazoles; Interleukin-1; Interleukin-6; Intestinal Mucosa; Intestine, Small; Iodine Radioisotopes; Leucine; Leukocytes; Male; Pancreatitis; Peroxidase; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Serum Albumin; Taurodeoxycholic Acid	2005
Applying Ockham's razor to pancreatitis prognostication: a four-variable predictive model. Annals of surgery, 2006, Volume: 243, Issue:3 Topics: APACHE; Female; Follow-Up Studies; Humans; Imidazoles; Leucine; Male; Middle Aged; Models, Theoretical; Pancreatitis, Acute Necrotizing; Platelet Activating Factor; Prognosis; Randomized Controlled Trials as Topic; ROC Curve; Severity of Illness Index; Survival Rate	2006
Nupafant, a PAF-antagonist prototype for suppression of ventricular fibrillation without liability for QT prolongation? British journal of pharmacology, 2006, Volume: 149, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrocardiography; Leucine; Male; Platelet Activating Factor; Rats; Rats, Wistar; Sulfonamides; Ventricular Fibrillation	2006
A novel role for leucocytes in determining the severity of acute pancreatitis. Gut, 2009, Volume: 58, Issue:11 Topics: Acute Disease; Animals; Biomarkers; Capillaries; Humans; Imidazoles; Inflammation Mediators; Leucine; Leukocytes; Mice; Pancreatitis; Platelet Activating Factor; Prognosis; Severity of Illness Index	2009