Page last updated: 2024-09-02

1-hexadecyl-2-acetyl-glycero-3-phosphocholine and l 663536

1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with l 663536 in 24 studies

Compound Research Comparison

Studies
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Trials
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Recent Studies (post-2010)
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Studies
(l 663536)
Trials
(l 663536)
Recent Studies (post-2010) (l 663536)
9,1561875524854138

Protein Interaction Comparison

ProteinTaxonomy1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50)l 663536 (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.023
Prostaglandin E synthaseHomo sapiens (human)2.2274
Prostaglandin G/H synthase 1Ovis aries (sheep)8
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)0.57
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.023
Arachidonate 5-lipoxygenase-activating proteinHomo sapiens (human)0.025
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.023
Prostaglandin G/H synthase 2Homo sapiens (human)2.4
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.023
Leukotriene C4 synthaseHomo sapiens (human)3
Macrophage-expressed gene 1 proteinHomo sapiens (human)2.2
GABA theta subunitRattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.023
Prostaglandin E synthase 2Homo sapiens (human)1.6

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's17 (70.83)18.2507
2000's7 (29.17)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rola-Pleszczynski, M; Thivierge, M1
Bienvenu, K; Granger, DN; Russell, J1
Hu, W; Kinnaird, AA; Man, RY1
Hu, WM; Man, RY1
Borgeat, P; Laviolette, M; Ménard, L; Naccache, PH; Pilote, S1
Eskafi, S; Müller, S; Nigam, S; Zhang, H1
Granger, DN; Panés, J; Russell, JM; Wallace, JL; Wolf, RE1
Martin, D; Nadler, JV; Peterson, CL; Thompson, MA1
Dahlén, SE; Jonsson, EW1
Fruchtmann, R; Hatzelmann, A; Mohrs, KH; Müller-Peddinghaus, R; Raddatz, S1
Jamieson, D; Lin, Y1
Kinnaird, AA; Man, RY1
Closa, D; Gelpí, E; Hotter, G; Pi, F; Prats, N; Roselló-Catafau, J1
Andrade, LE; Jancar, S; Rocha, FA; Russo, M1
Waller, KP1
Fukuchi, Y; Ishii, S; Katayama, H; Nagase, T; Ouchi, Y; Shimizu, T1
Jancar, S; Steil, AA; Tavares de Lima, W1
Sakai, H; Suzuki, T; Takeguchi, N1
Fietzner, K; Fink, L; Grimminger, F; Hattar, K; Himmel, B; Seeger, W; Sibelius, U1
Kolaczkowska, E; Plytycz, B; Seljelid, R; Shahzidi, S; van Rooijen, N1
Grandel, U; Grimminger, F; Hattar, K; Hoffmann, S; Mayer, K; Schenkel, A; Seeger, W; Sibelius, U1
Benjamim, CF; Cunha, Fde Q; Ferreira, SH; Rios-Santos, F; Zavery, D1
Gaudreault, E; Rola-Pleszczynski, M; Stankova, J1
Anderson, R; Steel, HC; Theron, AJ; Tintinger, GR1

Other Studies

24 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and l 663536

ArticleYear
Platelet-activating factor enhances interleukin-6 production by alveolar macrophages.
    The Journal of allergy and clinical immunology, 1992, Volume: 90, Issue:5

    Topics: Animals; Cells, Cultured; Diterpenes; Ginkgolides; Indoles; Interleukin-6; Lactones; Leukotriene B4; Macrophages, Alveolar; Male; Platelet Activating Factor; Rats; Rats, Wistar

1992
Leukotriene B4 mediates shear rate-dependent leukocyte adhesion in mesenteric venules.
    Circulation research, 1992, Volume: 71, Issue:4

    Topics: Animals; Antigens, CD; Azepines; Benzopyrans; Cats; CD18 Antigens; Endothelium, Vascular; Indoles; Leukocytes; Leukotriene B4; Mesenteric Veins; Platelet Activating Factor; Receptors, Leukocyte-Adhesion; Triazoles; Venules

1992
Mechanisms of the coronary vascular effects of platelet-activating factor in the rat perfused heart.
    British journal of pharmacology, 1991, Volume: 103, Issue:1

    Topics: Animals; Blood Pressure; Coronary Circulation; Diterpenes; Ginkgolides; Heart; In Vitro Techniques; Indoles; Indomethacin; Lactones; Leukotriene Antagonists; Leukotriene B4; Perfusion; Phenylbutyrates; Piperazines; Platelet Activating Factor; Rats; Rats, Inbred Strains; SRS-A

1991
Interaction of vasoactive substances released by platelet-activating factor in the rat perfused heart.
    British journal of pharmacology, 1991, Volume: 104, Issue:4

    Topics: Animals; Arachidonic Acids; Blood Gas Analysis; Coronary Circulation; Cyclooxygenase Inhibitors; Heart; In Vitro Techniques; Indoles; Indomethacin; Leukotriene Antagonists; Perfusion; Phenylbutyrates; Platelet Activating Factor; Potassium; Rats; Rats, Inbred Strains; Sodium; SRS-A; Vasoconstriction

1991
Inhibitory effects of MK-886 on arachidonic acid metabolism in human phagocytes.
    British journal of pharmacology, 1990, Volume: 100, Issue:1

    Topics: Actins; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cell Survival; Chromatography, High Pressure Liquid; Colony-Stimulating Factors; Eosinophils; Humans; In Vitro Techniques; Indoles; Leukotriene Antagonists; Leukotrienes; Neutrophils; Phagocytes; Platelet Activating Factor; Superoxides

1990
Evidence for the predominant role of intracellular PAF binding sites in the regulation of phospholipase A2 in human neutrophils.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: Alkaloids; Azepines; Humans; Indoles; Leukotriene Antagonists; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staurosporine; Triazoles

1995
Effects of tenidap on leukocyte-endothelial cell adhesion in mesenteric venules.
    The Journal of rheumatology, 1995, Volume: 22, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Endothelium, Vascular; Indoles; Indomethacin; Leukocytes; Leukotriene Antagonists; Male; Oxindoles; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Splanchnic Circulation; Venules

1995
Modulation of glutamate and aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic acid metabolism.
    Journal of neurochemistry, 1995, Volume: 64, Issue:3

    Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arginine; Aspartic Acid; Female; Flavanones; Flavonoids; gamma-Aminobutyric Acid; Glutamates; Hippocampus; In Vitro Techniques; Indoles; Indomethacin; Masoprocol; omega-N-Methylarginine; Platelet Activating Factor; Potassium; Prostaglandin-Endoperoxide Synthases; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Taurine

1995
Interactions between leukotrienes and histamine in the anaphylactic contraction of guinea pig lung parenchyma.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:2

    Topics: Anaphylaxis; Animals; Azepines; Guinea Pigs; Histamine; In Vitro Techniques; Indoles; Indomethacin; Leukotriene Antagonists; Leukotrienes; Lung; Male; Muscle Contraction; Ovalbumin; Platelet Activating Factor; Quinolines; Triazoles

1994
Mode of action of the new selective leukotriene synthesis inhibitor BAY X 1005 ((R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid) and structurally related compounds.
    Biochemical pharmacology, 1993, Jan-07, Volume: 45, Issue:1

    Topics: Animals; Arachidonic Acid; Binding Sites; Binding, Competitive; Cell-Free System; Humans; Hydroxyeicosatetraenoic Acids; Indoles; Kinetics; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Platelet Activating Factor; Quinolines; Rats; Structure-Activity Relationship; Subcellular Fractions

1993
Are leukotrienes or PAF involved in hyperbaric oxygen toxicity?
    Agents and actions, 1993, Volume: 38, Issue:1-2

    Topics: Animals; Benzopyrans; Female; Furans; Indoles; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Lung; Male; Mice; Mice, Inbred BALB C; Oxygen; Platelet Activating Factor; Pressure; Propionates; Quinolines; Rats; Seizures; Specific Pathogen-Free Organisms; SRS-A

1993
Similar coronary vascular effects in the rat perfused heart of platelet-activating factor structural analogues with agonist and antagonist properties.
    British journal of pharmacology, 1995, Volume: 116, Issue:5

    Topics: Animals; Coronary Circulation; Heart; In Vitro Techniques; Indoles; Male; Perfusion; Piperazines; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Vasoconstriction; Vasodilation

1995
Free radical enhancement promotes leucocyte recruitment through a PAF and LTB4 dependent mechanism.
    Free radical biology & medicine, 1997, Volume: 22, Issue:6

    Topics: Animals; Diterpenes; Free Radicals; Ginkgolides; Indoles; Lactones; Leukotriene B4; Lipase; Male; Neutrophils; Pancreas; Pancreatitis; Peroxidase; Platelet Activating Factor; Rats; Rats, Wistar; Superoxide Dismutase; Superoxides; Xanthine; Xanthine Oxidase; Xanthines

1997
PAF modulates eicosanoids and TNF release in immune-complex arthritis in rats.
    Journal of lipid mediators and cell signalling, 1997, Volume: 16, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthus Reaction; Cattle; Dinoprostone; Eicosanoids; Indoles; Indomethacin; Injections, Intra-Articular; Leukotriene B4; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Rabbits; Rats; Rats, Wistar; Synovial Fluid; Thromboxane B2; Tumor Necrosis Factor-alpha

1997
Modulation of endotoxin-induced inflammation in the bovine teat using antagonists/inhibitors to leukotrienes, platelet activating factor and interleukin 1 beta.
    Veterinary immunology and immunopathology, 1997, Volume: 57, Issue:3-4

    Topics: Adjuvants, Immunologic; Animals; Azepines; Blood Coagulation Factors; Cattle; Endotoxins; Female; Fibrinolytic Agents; Humans; Indoles; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Leukotriene Antagonists; Lipoxygenase Inhibitors; Mammary Glands, Animal; Mastitis, Bovine; Platelet Activating Factor; Platelet Aggregation Inhibitors; Recombinant Proteins; Sialoglycoproteins; Triazoles

1997
Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes.
    American journal of respiratory and critical care medicine, 1997, Volume: 156, Issue:5

    Topics: Animals; Azepines; Bronchi; Bronchial Hyperreactivity; Chromones; Indoles; Indomethacin; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Lung; Methacrylates; Mice; Mice, Transgenic; Phenylpropionates; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Leukotriene B4; Thromboxanes; Triazoles

1997
Modulation by lipid mediators of immune complex-induced lung inflammation in mice.
    European journal of pharmacology, 1998, Nov-13, Volume: 361, Issue:1

    Topics: Animals; Antigen-Antibody Complex; Arthus Reaction; Azepines; Benzopyrans; Blood Vessels; Bronchoalveolar Lavage Fluid; Capillary Permeability; Dose-Response Relationship, Drug; Eicosanoids; Hemoglobins; Immune Complex Diseases; Indoles; Indomethacin; Lipoxygenase Inhibitors; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neutrophils; Peroxidase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pneumonia; Receptors, Leukotriene B4; Species Specificity; Triazoles

1998
Thromboxane A(2)-mediated Cl(-) secretion induced by platelet-activating factor in isolated rat colon.
    European journal of pharmacology, 2000, Jul-21, Volume: 400, Issue:2-3

    Topics: 5-Lipoxygenase-Activating Proteins; Animals; Benzimidazoles; Benzoxepins; Carrier Proteins; Chlorides; Colon; Dinoprostone; Enzyme Inhibitors; Female; Imidazoles; In Vitro Techniques; Indoles; Intestinal Mucosa; Lipoxygenase Inhibitors; Membrane Proteins; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Thromboxane; Secretory Rate; Thromboxane A2; Thromboxane-A Synthase

2000
Cell density regulates neutrophil IL-8 synthesis: role of IL-1 receptor antagonist and soluble TNF receptors.
    Journal of immunology (Baltimore, Md. : 1950), 2001, May-15, Volume: 166, Issue:10

    Topics: Arachidonate 5-Lipoxygenase; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase Inhibitors; Dinoprostone; Down-Regulation; Humans; Immunosuppressive Agents; Indoles; Indomethacin; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Interleukin-8; Leukocyte Count; Lipopolysaccharides; Lipoxygenase Inhibitors; Neutrophils; Platelet Activating Factor; Pyridinium Compounds; Receptors, Interleukin-1; Receptors, Tumor Necrosis Factor; Sialoglycoproteins; Solubility; Tumor Necrosis Factor-alpha; Up-Regulation

2001
Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes.
    Inflammation, 2002, Volume: 26, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capillary Leak Syndrome; Capillary Permeability; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cysteine; Diterpenes; Eicosanoids; Enzyme Induction; Ginkgolides; Histamine Release; Indoles; Indomethacin; Isoenzymes; Lactones; Leukotriene C4; Leukotrienes; Lipoxygenase Inhibitors; Macrophages, Peritoneal; Male; Mast Cells; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Nitrobenzenes; Peritonitis; Phospholipid Ethers; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Quinolines; Sulfonamides; Thioglycolates; Zymosan

2002
Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10.
    Critical care medicine, 2002, Volume: 30, Issue:10

    Topics: Arachidonic Acid; Autocrine Communication; Azepines; Escherichia coli; Humans; In Vitro Techniques; Indoles; Interleukin-10; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Lipopolysaccharide Receptors; Lipopolysaccharides; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Prospective Studies; Respiratory Burst; Superoxides; Triazoles

2002
A critical role of leukotriene B4 in neutrophil migration to infectious focus in cecal ligaton and puncture sepsis.
    Shock (Augusta, Ga.), 2003, Volume: 19, Issue:1

    Topics: Animals; Cecum; Cell Movement; Dihydropyridines; Eicosanoids; Imidazoles; Indoles; Inflammation; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred C57BL; Neutrophils; Peritoneum; Platelet Activating Factor; Prostaglandins; Time Factors; Wounds, Penetrating

2003
Involvement of leukotriene B4 receptor 1 signaling in platelet-activating factor-mediated neutrophil degranulation and chemotaxis.
    Prostaglandins & other lipid mediators, 2005, Volume: 75, Issue:1-4

    Topics: beta-N-Acetylhexosaminidases; Calcium Signaling; Chemotaxis, Leukocyte; Humans; Indoles; Kinetics; Lipoxygenase Inhibitors; Neutrophils; Platelet Activating Factor; Receptors, Leukotriene B4

2005
Itraconazole-mediated inhibition of calcium entry into platelet-activating factor-stimulated human neutrophils is due to interference with production of leukotriene B4.
    Clinical and experimental immunology, 2007, Volume: 150, Issue:1

    Topics: Adenosine Triphosphate; Antifungal Agents; Calcium; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Humans; Indoles; Itraconazole; Leukotriene Antagonists; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Spectrometry, Fluorescence; Tetrazoles

2007