1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with inositol 1,4,5-trisphosphate in 53 studies
| Studies (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Trials (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Recent Studies (post-2010) (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Studies (inositol 1,4,5-trisphosphate) | Trials (inositol 1,4,5-trisphosphate) | Recent Studies (post-2010) (inositol 1,4,5-trisphosphate) |
|---|---|---|---|---|---|
| 9,156 | 187 | 552 | 6,600 | 1 | 589 |
| Protein | Taxonomy | 1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50) | inositol 1,4,5-trisphosphate (IC50) |
|---|---|---|---|
| Inositol-trisphosphate 3-kinase A | Rattus norvegicus (Norway rat) | 4.45 | |
| Inositol 1,4,5-trisphosphate receptor type 2 | Homo sapiens (human) | 0.03 | |
| Inositol 1,4,5-trisphosphate receptor type 3 | Homo sapiens (human) | 0.03 | |
| Inositol 1,4,5-trisphosphate receptor type 1 | Homo sapiens (human) | 0.03 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (16.98) | 18.7374 |
| 1990's | 36 (67.92) | 18.2507 |
| 2000's | 6 (11.32) | 29.6817 |
| 2010's | 2 (3.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clarkson, WD; Heemskerk, JW; Sage, SO; Sargeant, P | 1 |
| Fujii, T; Hashizume, T; Sato, T | 1 |
| Ernest, MJ; Fruman, DA; Gamache, DA | 1 |
| Fujisawa, K; Izushi, K; Kamei, C; Mio, M; Tasaka, K; Yoshii, N | 1 |
| Bismuth, G; Randriamampita, C; Trautmann, A | 1 |
| Birke, FW; Ensinger, HA | 1 |
| Hagenlocker, BE; Walker, BA; Ward, PA | 1 |
| Elmore, M; Kellie, S; Murphy, CT; Westwick, J | 1 |
| Barnes, PJ; Challiss, RA; Chilvers, ER; Giembycz, MA; Kroegel, C | 1 |
| Block, LH; Emmons, LR; Imhof, E; Perruchoud, AP; Roth, M | 1 |
| Kambayashi, J; Kawasaki, T; Mori, T; Sakon, M; Shiba, E; Uemura, Y | 1 |
| Grandison, L | 1 |
| Bala, GA; Bleasdale, JE; Bundy, GL; Justen, JM; Sam, LM; Smith, RJ | 1 |
| Melder, DC; Olsen, RA; Powis, G; Schlager, JJ; Seewald, MJ | 1 |
| Kajiyama, Y; Murayama, T; Nomura, Y | 1 |
| Hampel, G; Jaffe, EA; Watanabe, K; Weksler, BB | 1 |
| Bhalla, RC; Fisher, RA; Sharma, RV | 1 |
| Barker, CJ; Downes, CP; Hawkins, PT; Stephens, LR | 1 |
| Friesen, LL; Gerrard, JM; Israels, SJ; McCrea, JM; Robinson, P | 1 |
| Schwertschlag, US; Whorton, AR | 1 |
| Shukla, SD | 1 |
| Gerrard, JM | 1 |
| Alkon, DL; Inoue, H; Kouchi, T; Sakakibara, M; Yoshioka, T | 1 |
| Bozzaro, S; Malchow, D; Schaloske, R; Sordano, C | 1 |
| Kellie, S; Murphy, CT; Westwick, J | 1 |
| Dohi, T; Kitayama, S; Morita, K; Okamoto, H; Shibata, K; Shirakawa, M | 1 |
| Imanishi, N; Koike, H; Morooka, S; Natsume, Y | 1 |
| Ahmed, A; Plevin, R; Sage, SO; Sharkey, AM; Shoaibi, MA; Smith, SK | 1 |
| Asmis, R; Dennis, EA | 1 |
| Murphy, CT; Westwick, J | 1 |
| Haga, K; Haga, T; Honda, Z; Izumi, T; Kameyama, K; Kurokawa, K; Sakanaka, C; Shimizu, T; Takano, T | 1 |
| Chiyotani, A; Isono, K; Kondo, M; Konno, K; Ozawa, Y; Takeuchi, S; Tamaoki, J | 1 |
| Asmis, R; Dennis, EA; Randriamampita, C; Tsien, RY | 1 |
| Abraham, WM; Ahmed, T; Lansing, M; Mansour, E; Mendelssohn, R; Robinson, MJ; Sorace, D; Syriste, T | 1 |
| Anstine, D; Emmons, LR; Hornung, M; Lefkowitz, H; Perruchoud, AP; Roth, M; Solèr, M | 1 |
| Inagami, T; Kawamoto, K; Kondo, T; Shiono, S; Yoshida, N | 1 |
| Ahmed, A; Plevin, R; Shoaibi, MA; Smith, SK | 1 |
| Samuelsson, J | 1 |
| Alaei, P; MacNulty, EE; Ryder, NS | 1 |
| Ghosh, S; Rao, AK; Sun, L; Yang, X | 1 |
| Abebe, W; Agrawal, DK; Ali, N | 1 |
| Gawdi, G; Gonzalez-Gronow, M; Misra, UK; Pizzo, SV | 1 |
| Hertelendy, F; Molnár, M; Rigó, J | 1 |
| Ishii, I; Izumi, T; Saito, E; Shimizu, T; Ui, M | 1 |
| Feijge, MA; Heemskerk, JW; Keularts, IM; van Gorp, RM; Vuist, WM | 1 |
| Bathgate, R; Cook, DI; Emerson, M; Harding, E; Lu, DP; O'Neill, C; Stojanov, T; Travis, AR | 1 |
| Callery, MP; Foley, DP; McDade, TP; Perugini, RA; Vittimberga, FJ | 1 |
| Göggel, R; Uhlig, S | 1 |
| Dransfield, I; Haslett, C; McMeekin, SR; Rossi, AG; Walker, TR | 1 |
| Beaulieu, MJ; Blanchet, MR; Cormier, Y; Daleau, P; Israël-Assayag, E | 1 |
| Ameer, A; Ibe, BO; Portugal, AM; Raj, JU; Renteria, L | 1 |
| Arteaga, A; Bae, R; Ibe, BO; Raj, JU | 1 |
| Armant, DR | 1 |
4 review(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and inositol 1,4,5-trisphosphate
| Article | Year |
|---|---|
Platelet protein phosphorylation.
Topics: Actin Cytoskeleton; Blood Platelets; Blood Proteins; Calcium; Carrier Proteins; Cyclic AMP; Cytoplasmic Granules; Cytoskeleton; Diglycerides; Gelsolin; Humans; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lysophospholipids; Microfilament Proteins; Microtubules; Molecular Weight; Myosins; Phosphatidic Acids; Phosphoproteins; Phosphorylation; Platelet Activating Factor; Platelet Aggregation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thromboxane A2 | 1985 |
Phospholipid metabolism and cell stimulus activation coupling in platelets and other blood cells.
Topics: Actins; Arachidonic Acid; Arachidonic Acids; Biological Evolution; Biological Transport; Blood Cells; Blood Platelets; Blood Vessels; Calcium; Cell Membrane; Diglycerides; Endoplasmic Reticulum; Hydrolysis; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lipid Bilayers; Lipids; Lysophosphatidylcholines; Lysophospholipids; Myosins; Organoids; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phospholipases A; Phospholipids; Platelet Activating Factor; Solubility; Type C Phospholipases; Water | 1984 |
Impaired activation of phospholipase D in polycythaemia vera-implications for the pathogenesis of the disease?
Topics: Enzyme Activation; Humans; Inositol 1,4,5-Trisphosphate; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidative Stress; Phospholipase D; Platelet Activating Factor; Polycythemia Vera; Tetradecanoylphorbol Acetate | 1995 |
Intracellular Ca2+ signaling and preimplantation development.
Topics: Blastocyst; Calcium; Calcium Signaling; Embryonic Development; Female; Fertilization; Gene Expression Regulation, Developmental; Humans; Inositol 1,4,5-Trisphosphate; Integrins; Male; Ovum; Platelet Activating Factor; Pregnancy; Spermatozoa | 2015 |
49 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and inositol 1,4,5-trisphosphate
| Article | Year |
|---|---|
Calcium influx evoked by Ca2+ store depletion in human platelets is more susceptible to cytochrome P-450 inhibitors than receptor-mediated calcium entry.
Topics: Adenosine Diphosphate; Blood Platelets; Calcium; Calcium Channels; Calcium-Transporting ATPases; Cell Compartmentation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Econazole; Humans; Hydroquinones; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Ion Channel Gating; Manganese; Miconazole; Osmolar Concentration; Platelet Activating Factor; Platelet Activation; Receptors, Cholinergic; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Terpenes; Thapsigargin; Thrombin; Vasopressins | 1992 |
Sphingosine enhances platelet aggregation through an increase in phospholipase C activity by a protein kinase C-independent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Calcium; Cell Membrane; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; Piperazines; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Rabbits; Sphingosine; Staurosporine; Thrombin; Type C Phospholipases | 1992 |
Changes in inositol 1,4,5-trisphosphate mass in agonist-stimulated human neutrophils.
Topics: Calcium Channels; Cholera Toxin; Cytochalasin B; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Platelet Activating Factor; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Respiratory Burst; Stimulation, Chemical; Virulence Factors, Bordetella | 1991 |
Inhibitory effect of MY-1250 on histamine release from rat peritoneal mast cells and guinea pig lung fragments: the elucidation of the mechanism.
Topics: Animals; Calcium; Cells, Cultured; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Inositol 1,4,5-Trisphosphate; Lung; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Platelet Activating Factor; Quinolones; Rats; Rats, Inbred Strains | 1991 |
Ca(2+)-induced Ca2+ release amplifies the Ca2+ response elicited by inositol trisphosphate in macrophages.
Topics: Animals; Calcium; Cells, Cultured; Feedback; Inositol 1,4,5-Trisphosphate; Ionomycin; Macrophages; Membrane Potentials; Mice; Platelet Activating Factor; Second Messenger Systems | 1991 |
Inhibition by the PAF antagonist WEB 2086 of PAF induced inositol-1,4,5-trisphosphate production in human platelets.
Topics: Adenosine Diphosphate; Azepines; Blood Platelets; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Platelet Activating Factor; Thrombin; Triazoles | 1991 |
Superoxide responses to formyl-methionyl-leucyl-phenylalanine in primed neutrophils. Role of intracellular and extracellular calcium.
Topics: Calcium; Cytoplasm; Extracellular Space; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Ionomycin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
The relationship between cytosolic Ca2+, sn-1,2-diacylglycerol and inositol 1,4,5-trisphosphate elevation in platelet-activating-factor-stimulated rabbit platelets. Influence of protein kinase C on production of signal molecules.
Topics: Alkaloids; Animals; Blood Platelets; Calcium; Cytosol; Diglycerides; Dose-Response Relationship, Drug; Homeostasis; Inositol 1,4,5-Trisphosphate; Kinetics; Phosphorylation; Platelet Activating Factor; Platelet Activation; Protein Kinase C; Rabbits; Staurosporine; Thromboxane B2 | 1991 |
Platelet-activating factor stimulates a rapid accumulation of inositol (1,4,5)trisphosphate in guinea pig eosinophils: relationship to calcium mobilization and degranulation.
Topics: Animals; Azepines; Calcium; Cell Separation; Cytoplasmic Granules; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Inositol 1,4,5-Trisphosphate; Male; Peritoneal Cavity; Platelet Activating Factor; Second Messenger Systems; Stimulation, Chemical; Time Factors; Triazoles | 1991 |
PAF-dependent phosphatidylinositol turnover in platelets: differences between asthmatics and normal individuals.
Topics: Acute Disease; Administration, Inhalation; Adolescent; Adult; Asthma; Blood Platelets; Bronchoconstriction; Female; Humans; Inositol 1,4,5-Trisphosphate; Male; Phosphatidylinositols; Platelet Activating Factor; Platelet Count | 1990 |
The correlation between Ca2+ influx and inositol 1, 4, 5-trisphosphate (IP3) formation in platelets stimulated by various agonists.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Humans; Inositol 1,4,5-Trisphosphate; Ionomycin; Platelet Activating Factor; Temperature; Thrombin; Thromboxane A2 | 1990 |
Platelet activating factor induces inositol phosphate accumulation in cultures of rat and bovine anterior pituitary cells.
Topics: Animals; Cattle; Cells, Cultured; Chlorides; Furans; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Lithium Chloride; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Pituitary Gland, Anterior; Platelet Activating Factor; Rats; Thyrotropin-Releasing Hormone; Type C Phospholipases | 1990 |
Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness.
Topics: Cell Membrane; Estrenes; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; L-Lactate Dehydrogenase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Pyrrolidinones; Signal Transduction; Type C Phospholipases | 1990 |
High molecular weight dextran sulfate inhibits intracellular Ca2+ release and decreases growth factor-induced increases in intracellular free Ca2+ in Swiss 3T3 fibroblasts.
Topics: Arachidonic Acid; Arachidonic Acids; Arginine Vasopressin; Bradykinin; Calcimycin; Calcium; Cells, Cultured; Dextran Sulfate; Dextrans; Fibroblasts; Guanosine Triphosphate; Halothane; Heparin; Inositol 1,4,5-Trisphosphate; Mitogens; Molecular Weight; Platelet Activating Factor; Receptors, Cell Surface | 1989 |
Pertussis toxin-sensitive GTP-binding proteins may regulate phospholipase A2 in response to thrombin in rabbit platelets.
Topics: Animals; Arachidonic Acids; Blood Platelets; Calcium; Digitonin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Norepinephrine; Pertussis Toxin; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rabbits; Serotonin; Thionucleotides; Thrombin; Virulence Factors, Bordetella | 1989 |
Selenium deficiency inhibits prostacyclin release and enhances production of platelet activating factor by human endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Arachidonic Acids; Calcium; Cells, Cultured; Endothelium, Vascular; Epoprostenol; Glutathione Peroxidase; Histamine; Humans; Inositol 1,4,5-Trisphosphate; Platelet Activating Factor; Selenium; Thrombin; Umbilical Veins | 1989 |
Platelet-activating factor increases inositol phosphate production and cytosolic free Ca2+ concentrations in cultured rat Kupffer cells.
Topics: Animals; Calcium; Cells, Cultured; Cytosol; Enzyme Activation; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kupffer Cells; Male; Platelet Activating Factor; Protein Kinase C; Quinolines; Rats; Rats, Inbred Strains; Sugar Phosphates; Tetradecanoylphorbol Acetate | 1989 |
Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation.
Topics: Adenosine Triphosphate; Animals; Brain; Cells, Cultured; Chromatography, High Pressure Liquid; Cytosol; Humans; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Macrophages; Mice; Phosphorylation; Platelet Activating Factor; Rats; Receptors, Cell Surface; Sugar Phosphates | 1988 |
Platelet-activating factor-induced homologous and heterologous desensitization in cultured vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta; Benzofurans; Calcium; Cells, Cultured; Cytosol; Diglycerides; Fluorescent Dyes; Fura-2; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Male; Muscle, Smooth, Vascular; Platelet Activating Factor; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate; Vasopressins | 1988 |
Platelet activating factor-stimulated formation of inositol triphosphate in platelets and its regulation by various agents including Ca2+, indomethacin, CV-3988, and forskolin.
Topics: Animals; Blood Platelets; Calcium; Colforsin; Diterpenes; Dose-Response Relationship, Drug; Indomethacin; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Models, Biological; Phospholipid Ethers; Platelet Activating Factor; Rabbits; Sugar Phosphates; Thiazoles; Time Factors | 1985 |
Induction of photoresponse by the hydrolysis of polyphosphoinositides in the Hermissenda type B photoreceptor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Hydrolysis; Inositol 1,4,5-Trisphosphate; Kinetics; Lithium Chloride; Models, Biological; Neomycin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Photoreceptor Cells, Invertebrate; Platelet Activating Factor; Pyrimidinones; Snails; Spermine; Thiazoles; Thionucleotides; Type C Phospholipases | 1994 |
Stimulation of calcium influx by platelet activating factor in Dictyostelium.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Calcium; Cell Membrane; Cyclic AMP; Dictyostelium; Diterpenes; Dose-Response Relationship, Drug; Estrenes; Ginkgolides; GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Kinetics; Lactones; Platelet Activating Factor; Pyrrolidinones; Species Specificity; Time Factors | 1995 |
Tyrosine-kinase activity in rabbit platelets stimulated with platelet-activating factor. The effect of inhibiting tyrosine kinase with genistein on platelet-signal-molecule elevation and functional responses.
Topics: Animals; Blood Platelets; Cells, Cultured; Genistein; Inositol 1,4,5-Trisphosphate; Ionomycin; Isoflavones; Phosphorylation; Phosphotyrosine; Platelet Activating Factor; Protein-Tyrosine Kinases; Rabbits; Signal Transduction; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2; Type C Phospholipases; Tyrosine | 1993 |
Regulation by protein kinase C of platelet-activating factor- and thapsigargin-induced calcium entry in rabbit neutrophils.
Topics: Alkaloids; Animals; Calcium; Calcium Chloride; Calcium-Transporting ATPases; Cytosol; Electrophysiology; Enzyme Activation; Inositol 1,4,5-Trisphosphate; Neutrophils; Platelet Activating Factor; Protein Kinase C; Rabbits; Spectrometry, Fluorescence; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1994 |
Effects of platelet activating factor receptor antagonists on intracellular platelet activating factor function in neutrophils.
Topics: Animals; Azepines; Binding, Competitive; Calcium; Cell Count; Cell Degranulation; Chemotaxis, Leukocyte; Free Radical Scavengers; Inositol 1,4,5-Trisphosphate; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridines; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reference Standards; Signal Transduction; Structure-Activity Relationship; Superoxides; Thiazoles; Thiazolidines; Triazoles; Vitamin E | 1994 |
Functional platelet-activating factor receptors linked to inositol lipid hydrolysis, calcium mobilization and tyrosine kinase activity in the human endometrial HEC-1B cell line.
Topics: Azepines; Calcium; Cell Line; Endometrium; Female; Fura-2; Humans; Hydrolysis; Inositol; Inositol 1,4,5-Trisphosphate; Lipid Metabolism; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1994 |
PAF stimulates cAMP formation in P388D1 macrophage-like cells via the formation and secretion of prostaglandin E2 in an autocrine fashion.
Topics: Animals; Cell Line; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Inositol 1,4,5-Trisphosphate; Isoquinolines; Lipopolysaccharides; Mice; Models, Biological; Platelet Activating Factor; Signal Transduction; Sulfonamides | 1994 |
Role of type 1 and type 2A phosphatases in signal transduction of platelet-activating-factor-stimulated rabbit platelets.
Topics: Animals; Azepines; Blood Platelets; Calcium; Cations, Divalent; Indoles; Inositol 1,4,5-Trisphosphate; Ionomycin; Maleimides; Manganese; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Rabbits; Signal Transduction; Triazoles | 1994 |
Role of cytoplasmic tail phosphorylation sites of platelet-activating factor receptor in agonist-induced desensitization.
Topics: Amino Acid Sequence; Animals; Base Sequence; beta-Adrenergic Receptor Kinases; Calcium; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Guinea Pigs; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; Molecular Sequence Data; Mutation; Oligodeoxyribonucleotides; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Thrombin | 1994 |
Effect of platelet-activating factor on intracellular free calcium in cow tracheal epithelium.
Topics: Animals; Bradykinin; Calcium; Cattle; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Fura-2; Inositol 1,4,5-Trisphosphate; Platelet Activating Factor; Pyridinium Compounds; Trachea; Verapamil | 1994 |
Intracellular Ca2+, inositol 1,4,5-trisphosphate and additional signalling in the stimulation by platelet-activating factor of prostaglandin E2 formation in P388D1 macrophage-like cells.
Topics: Calcium; Cell Line; Dinoprostone; Egtazic Acid; Inositol 1,4,5-Trisphosphate; Ionomycin; Lipopolysaccharides; Macrophages; Pertussis Toxin; Platelet Activating Factor; Protein-Tyrosine Kinases; Signal Transduction; Virulence Factors, Bordetella | 1994 |
Heparin prevents antigen-induced airway hyperresponsiveness: interference with IP3-mediated mast cell degranulation?
Topics: Animals; Antigens; Bronchoconstriction; Cell Degranulation; Heparin; Inositol 1,4,5-Trisphosphate; Mast Cells; Platelet Activating Factor; Respiratory Hypersensitivity; Sheep | 1994 |
Inhibition of receptor-mediated platelet activation by nedocromil sodium.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calcium; Humans; Inositol 1,4,5-Trisphosphate; Nedocromil; Platelet Activating Factor; Platelet Activation; Platelet Membrane Glycoproteins; Protein Kinase C; Quinolones; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1993 |
Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors.
Topics: Animals; Calcium; Cell Membrane; Dopamine; Inositol 1,4,5-Trisphosphate; Kinetics; Lysophospholipids; PC12 Cells; Phospholipase D; Platelet Activating Factor; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid | 1993 |
Oestradiol-17 beta modulates PAF-evoked phospholipase D activity but not inositide-lipid hydrolysis in human endometrial cell line, HEC-1B.
Topics: Carcinogens; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Endometrium; Epithelium; Estradiol; Female; Humans; Hydrolysis; Inositol 1,4,5-Trisphosphate; Phosphatidylinositols; Phospholipase D; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Type C Phospholipases; Up-Regulation | 1995 |
Inhibition of protein prenylation down-regulates signalling by inflammatory mediators in human keratinocytes.
Topics: Adenosine Triphosphate; Benzylamines; Bradykinin; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Inositol 1,4,5-Trisphosphate; Keratinocytes; Mevalonic Acid; Platelet Activating Factor; Protein Prenylation; Signal Transduction; Thiophenes; Thrombin | 1996 |
Human platelet signaling defect characterized by impaired production of inositol-1,4,5-triphosphate and phosphatidic acid and diminished Pleckstrin phosphorylation: evidence for defective phospholipase C activation.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Blood Proteins; Calcimycin; Calcium; Diglycerides; Enzyme Activation; Female; Hemorrhagic Disorders; Humans; Inositol 1,4,5-Trisphosphate; Male; Middle Aged; Myosin Light Chains; Phosphatidic Acids; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoproteins; Phosphoric Diester Hydrolases; Phosphorylation; Platelet Activating Factor; Platelet Aggregation; Protein Processing, Post-Translational; Serotonin; Signal Transduction; Thrombin | 1996 |
Platelet-activating factor-induced inositol 1,4,5-trisphosphate generation in undifferentiated and differentiated U937 cells: role of tyrosine kinase.
Topics: Azepines; Blotting, Western; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Humans; Inositol 1,4,5-Trisphosphate; Isoflavones; Monocytes; Phosphorylation; Platelet Activating Factor; Protein-Tyrosine Kinases; Triazoles | 1996 |
Up-regulation of the alpha2-macroglobulin signaling receptor on rheumatoid synovial fibroblasts.
Topics: alpha-Macroglobulins; Arthritis, Rheumatoid; Calcium; Cell Division; Cells, Cultured; Fibroblasts; Humans; Inositol 1,4,5-Trisphosphate; Low Density Lipoprotein Receptor-Related Protein-1; Platelet Activating Factor; Receptors, Immunologic; Signal Transduction; Synovial Membrane; Up-Regulation | 1997 |
Signal transduction in human myometrial cells.
Topics: Calcium; Cell Membrane Permeability; Cells, Cultured; Dinoprost; Female; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; Muscle, Smooth; Myometrium; Oxytocin; Phosphatidylinositols; Platelet Activating Factor; Signal Transduction | 1996 |
Agonist-induced sequestration, recycling, and resensitization of platelet-activating factor receptor. Role of cytoplasmic tail phosphorylation in each process.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Cell Membrane; CHO Cells; Clathrin; Cricetinae; Folic Acid; Guinea Pigs; Inositol 1,4,5-Trisphosphate; Models, Molecular; Oligopeptides; Peptides; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Biosynthesis; Protein Structure, Secondary; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Transfection | 1998 |
alpha(2A)-adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels.
Topics: Adrenergic alpha-Agonists; Aspirin; Blood Platelets; Brimonidine Tartrate; Calcium; Calcium Chloride; Carbazoles; Cyclic AMP; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Epinephrine; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Models, Biological; Phosphorylation; Platelet Activating Factor; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Prostaglandins E; Pyrroles; Quinoxalines; Receptors, Adrenergic, alpha-2; Stimulation, Chemical; Thapsigargin; Thimerosal; Thrombin; Time Factors | 2000 |
Characterization and functional significance of calcium transients in the 2-cell mouse embryo induced by an autocrine growth factor.
Topics: Animals; Autocrine Communication; Blastocyst; Calcium; Estrenes; Inositol 1,4,5-Trisphosphate; Macrocyclic Compounds; Mice; Oxazoles; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyrrolidinones | 2000 |
Endotoxin fails to stimulate inositol triphosphate production in macrophages.
Topics: Cell Line; Drug Tolerance; Endotoxins; Inositol 1,4,5-Trisphosphate; Lipopolysaccharides; Macrophages; Platelet Activating Factor; Time Factors | 1999 |
The inositol trisphosphate pathway mediates platelet-activating-factor-induced pulmonary oedema.
Topics: Animals; Calcium; Disease Models, Animal; Endothelium; Female; Inositol 1,4,5-Trisphosphate; Intracellular Signaling Peptides and Proteins; Lung; Myosin-Light-Chain Kinase; Organ Size; Platelet Activating Factor; Protein Serine-Threonine Kinases; Pulmonary Edema; Rats; Rats, Wistar; Reference Values; rho-Associated Kinases | 2005 |
E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils.
Topics: Calcium; Calcium Signaling; CD18 Antigens; Cell Adhesion; E-Selectin; Endothelium, Vascular; Humans; Inositol 1,4,5-Trisphosphate; Neutrophils; Nitrendipine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptor Aggregation; Receptors, G-Protein-Coupled; src-Family Kinases; TRPC Cation Channels; TRPC6 Cation Channel | 2006 |
Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation.
Topics: Anti-Inflammatory Agents; Calcium; Calcium Channel Blockers; Dimethylphenylpiperazinium Iodide; Enzyme Activation; Humans; Inositol 1,4,5-Trisphosphate; Intracellular Membranes; Lipopolysaccharides; Macrophages, Alveolar; Monocytes; Nicotinic Agonists; Phosphatidylinositol 3-Kinases; Platelet Activating Factor; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Type C Phospholipases | 2006 |
Platelet-activating factor modulates activity of cyclic nucleotides in fetal ovine pulmonary vascular smooth muscle.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Female; Fetus; Inositol 1,4,5-Trisphosphate; Lung; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pregnancy; Receptors, G-Protein-Coupled; Sheep | 2007 |
Albuterol isomers modulate platelet-activating factor synthesis and receptor signaling in human bronchial smooth muscle cells.
Topics: Albuterol; Azepines; Bronchi; Bronchodilator Agents; Cell Line; Cell Proliferation; Humans; Inositol 1,4,5-Trisphosphate; Myocytes, Smooth Muscle; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles | 2012 |