Page last updated: 2024-09-02

1-hexadecyl-2-acetyl-glycero-3-phosphocholine and ibuprofen

1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with ibuprofen in 16 studies

Compound Research Comparison

Studies
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Trials
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Recent Studies (post-2010)
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Studies
(ibuprofen)
Trials
(ibuprofen)
Recent Studies (post-2010) (ibuprofen)
9,15618755210,2451,7814,267

Protein Interaction Comparison

ProteinTaxonomy1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50)ibuprofen (IC50)
Prostaglandin G/H synthase 1 Bos taurus (cattle)2.9
Prostaglandin G/H synthase 2 Bos taurus (cattle)1.1
AlbuminBos taurus (cattle)3
Prostaglandin G/H synthase 1Ovis aries (sheep)4.0919
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.22
Prostaglandin G/H synthase 1Homo sapiens (human)1.6273
Caspase-1Homo sapiens (human)7.2667
Substance-P receptorCavia porcellus (domestic guinea pig)1.1
Prostaglandin G/H synthase 2Homo sapiens (human)3.0687
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)1.3
Aldo-keto reductase family 1 member C3Homo sapiens (human)10
Caspase-3Homo sapiens (human)7.2667
Caspase-4Homo sapiens (human)7.2667
4-aminobutyrate aminotransferase, mitochondrialRattus norvegicus (Norway rat)1.1
Caspase-5Homo sapiens (human)7.2667
Caspase-9Homo sapiens (human)7.2667
Prostaglandin G/H synthase 2Ovis aries (sheep)1.1375
Mu-type opioid receptorCavia porcellus (domestic guinea pig)2.9
Fatty-acid amide hydrolase 1Rattus norvegicus (Norway rat)5
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.54
Solute carrier family 22 member 6Homo sapiens (human)8
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)1.3

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19902 (12.50)18.7374
1990's13 (81.25)18.2507
2000's1 (6.25)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kimura, K; Mochizuki, K; Ohta, M; Shiota, M; Sugano, T1
DeBuysere, MS; Gandhi, CR; Olson, MS1
Bautista, AP; Spitzer, JJ1
Grunfeld, S; Han, E; Joseph, R; Welch, KM1
Kaliner, M; Logun, C; Lundgren, JD; Shelhamer, JH1
Baum, TD; Feldman, HS; Fink, MP; Heard, SO; Latka, CA1
Adi, S; Feingold, KR; Fiers, W; Grunfeld, C; Moser, A; Soued, M1
Lapointe, DS; Olson, MS1
Makowka, L; Mazzaferro, V; Ontell, SJ; Ove, P; Starzl, TE; Trager, J1
Fletcher, JR; Khimenko, PL; Logsdon, P; Rizzo, A; Taylor, AE; Townsley, MI1
Rola-Pleszczynski, M; Thivierge, M1
Iwao, H; Kim, S; Miura, K; Yamanaka, S; Yukimura, T1
Kroegel, C; Matthys, H1
Mue, S; Ohuchi, K; Watanabe, M; Yamada, M1
Ebara, T; Imanishi, M; Iwao, H; Kim, S; Matsuura, T; Miura, K; Yamano, Y1
Downing, SJ; Leese, HJ; Maguiness, SD; Tay, JI; Watson, A1

Other Studies

16 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and ibuprofen

ArticleYear
Different preparations of zymosan induce glycogenolysis independently in the perfused rat liver. Involvement of mannose receptors, peptide-leukotrienes and prostaglandins.
    The Biochemical journal, 1992, May-01, Volume: 283 ( Pt 3)

    Topics: Animals; Chromones; Glycogen; Hot Temperature; Ibuprofen; Isoproterenol; Liver; Male; Mannans; Masoprocol; Opsonin Proteins; Platelet Activating Factor; Prostaglandins; Rats; Rats, Inbred Strains; Receptors, Immunologic; Receptors, Leukotriene; Solubility; Zymosan

1992
Platelet-activating factor-mediated synthesis of prostaglandins in rat Kupffer cells.
    Biochimica et biophysica acta, 1992, Jul-22, Volume: 1136, Issue:1

    Topics: Animals; Bacterial Toxins; Calcium; Cells, Cultured; Cyclic AMP; Enzyme Activation; Ibuprofen; Kupffer Cells; Male; Masoprocol; Platelet Activating Factor; Prostaglandins; Protein Kinase C; Rats; Rats, Inbred Strains

1992
Platelet activating factor stimulates and primes the liver, Kupffer cells and neutrophils to release superoxide anion.
    Free radical research communications, 1992, Volume: 17, Issue:3

    Topics: Animals; Anions; Free Radicals; Ibuprofen; In Vitro Techniques; Kupffer Cells; Lipopolysaccharides; Liver; Male; Neutrophils; Peroxidase; Platelet Activating Factor; Quinolinium Compounds; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxides; Zymosan

1992
[Effect of chronic antiplatelet treatment on platelet activating factor-induced platelet activity in stroke].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1991, Volume: 24, Issue:1

    Topics: Adenosine Triphosphate; Adult; Aspirin; Calcium; Cerebrovascular Disorders; Female; Humans; Ibuprofen; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation

1991
Platelet activating factor and tracheobronchial respiratory glycoconjugate release in feline and human explants: involvement of the lipoxygenase pathway.
    Agents and actions, 1990, Volume: 30, Issue:3-4

    Topics: Animals; Bronchi; Cats; Culture Techniques; Glyceryl Ethers; Glycoconjugates; Humans; Ibuprofen; Lipoxygenase; Masoprocol; Platelet Activating Factor; Thiazoles; Trachea; Tritium

1990
Endotoxin-induced myocardial depression in rats: effect of ibuprofen and SDZ 64-688, a platelet activating factor receptor antagonist.
    The Journal of surgical research, 1990, Volume: 48, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Body Weight; Depression, Chemical; Endotoxins; Escherichia coli; Heart Rate; Ibuprofen; In Vitro Techniques; Lipopolysaccharides; Male; Myocardial Contraction; Platelet Activating Factor; Rats; Rats, Inbred Strains

1990
Search for mediators of the lipogenic effects of tumor necrosis factor: potential role for interleukin 6.
    Cancer research, 1990, Jul-15, Volume: 50, Issue:14

    Topics: Animals; Aspirin; Azepines; Cholesterol; Fatty Acids; Ibuprofen; Interleukin-6; Lipids; Liver; Male; Mice; Mice, Inbred C57BL; Oleic Acid; Oleic Acids; Pentoxifylline; Phenoxybenzamine; Platelet Activating Factor; Propranolol; Rats; Rats, Inbred Strains; Reference Values; Triazoles; Triglycerides; Tumor Necrosis Factor-alpha

1990
Platelet-activating factor-stimulated hepatic glycogenolysis is not mediated through cyclooxygenase-derived metabolites of arachidonic acid.
    The Journal of biological chemistry, 1989, Jul-25, Volume: 264, Issue:21

    Topics: Animals; Arachidonic Acids; Glucose; Ibuprofen; Liver; Liver Circulation; Liver Glycogen; Male; Platelet Activating Factor; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Reference Values; Thromboxane B2; Vascular Resistance

1989
Pharmacologic modulation of experimental postischemic hepatic function.
    Annals of surgery, 1989, Volume: 209, Issue:2

    Topics: Animals; Bile; Disease Models, Animal; Drug Evaluation, Preclinical; Hot Temperature; Ibuprofen; Ischemia; Liver; Male; Microscopy, Electron; Perfusion; Platelet Activating Factor; Quinolinium Compounds; Rats; Rats, Inbred Strains; Reperfusion Injury; Superoxide Dismutase; Transaminases

1989
Platelet-activating factor increases vascular resistance in rat hindquarters by thromboxane A2.
    The American journal of physiology, 1995, Volume: 268, Issue:5 Pt 2

    Topics: Animals; Azepines; Blood Pressure; Capillary Permeability; Hindlimb; Ibuprofen; Male; Phenylacetates; Platelet Activating Factor; Rats; Rats, Wistar; Regional Blood Flow; Sulfonamides; Thromboxane A2; Thromboxanes; Triazoles; Vascular Resistance

1995
Involvement of both cyclooxygenase and lipoxygenase pathways in platelet-activating factor-induced interleukin-6 production by alveolar macrophages.
    Annals of the New York Academy of Sciences, 1994, May-28, Volume: 725

    Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Arachidonate 5-Lipoxygenase; Aspirin; Bucladesine; Cyclooxygenase Inhibitors; Dinoprostone; Ibuprofen; Indomethacin; Interleukin-6; Leukotriene B4; Macrophages, Alveolar; Male; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha

1994
Effect of the platelet-activating factor antagonist, TCV-309, and the cyclo-oxygenase inhibitor, ibuprofen, on the haemodynamic changes in canine experimental endotoxic shock.
    British journal of pharmacology, 1993, Volume: 110, Issue:4

    Topics: Animals; Dogs; Endotoxins; Female; Hemodynamics; Ibuprofen; Isoquinolines; Male; Nitric Oxide; Platelet Activating Factor; Pyridinium Compounds; Shock, Septic; Tetrahydroisoquinolines

1993
Platelet-activating factor-induced human eosinophil activation. Generation and release of cyclo-oxygenase metabolites in human blood eosinophils from asthmatics.
    Immunology, 1993, Volume: 78, Issue:2

    Topics: Asthma; Cells, Cultured; Dose-Response Relationship, Drug; Eosinophils; Humans; Ibuprofen; Leukocytes; Platelet Activating Factor; Prostaglandins; Thromboxane B2

1993
Enhancement by cyclo-oxygenase inhibitors of platelet-activating factor production in thapsigargin-stimulated macrophages.
    British journal of pharmacology, 1995, Volume: 116, Issue:3

    Topics: Animals; Arachidonic Acid; Bucladesine; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Ibuprofen; Indomethacin; Macrophages, Peritoneal; Male; Naproxen; Platelet Activating Factor; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Terpenes; Thapsigargin

1995
Role of platelet-activating factor and prostanoids in hemodynamic changes in rat experimental endotoxic shock.
    Japanese journal of pharmacology, 1996, Volume: 71, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds; Fatty Acids, Monounsaturated; Hemodynamics; Ibuprofen; Isoquinolines; Male; Platelet Activating Factor; Prostaglandins; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Shock, Septic; Tetrahydroisoquinolines

1996
Effect of inflammatory mediators on the physiology of the human Fallopian tube.
    Human fertility (Cambridge, England), 2002, Volume: 5, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Diclofenac; Dose-Response Relationship, Drug; Electric Conductivity; Electrophysiology; Epithelial Cells; Fallopian Tubes; Female; Histamine; Humans; Ibuprofen; Indomethacin; Inflammation Mediators; Muscle Contraction; Muscle, Smooth; Naproxen; Pelvic Pain; Platelet Activating Factor

2002