Page last updated: 2024-09-02

1-hexadecyl-2-acetyl-glycero-3-phosphocholine and eicosapentaenoic acid

1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with eicosapentaenoic acid in 21 studies

Compound Research Comparison

Studies
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Trials
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Recent Studies (post-2010)
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Studies
(eicosapentaenoic acid)
Trials
(eicosapentaenoic acid)
Recent Studies (post-2010) (eicosapentaenoic acid)
9,1561875527,1711,3043,623

Protein Interaction Comparison

ProteinTaxonomy1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50)eicosapentaenoic acid (IC50)
Chain A, Protein (peroxisome Proliferator Activated Receptor (ppar-delta))Homo sapiens (human)4
Prostaglandin G/H synthase 2Ovis aries (sheep)7.1
Oxoeicosanoid receptor 1Homo sapiens (human)2

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19907 (33.33)18.7374
1990's9 (42.86)18.2507
2000's4 (19.05)29.6817
2010's1 (4.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Misso, NL; Passarelli, M; Phillips, MJ; Thompson, PJ1
Chilton, FH; Connell, TR; Triggiani, M1
Careaga-Houck, M; Sprecher, H1
Holub, BJ; Philbrick, DJ; Yeo, YK1
Beilin, LJ; Codde, JP; Hill, KJ; Mori, TA; Vandongen, R1
Bullock, BC; Chabot, MC; Schmitt, JD; Wykle, RL1
Austen, KF; Kylander, KA; Lee, TH; Lewis, RA; Robin, JL; Sperling, RI1
Barden, A; Beilin, LJ; Codde, JP; Croft, KD; Vandongen, R1
Dondero-Zahn, C; Nytko, D; Pickett, WC; Ramesha, C1
Dyerberg, J; Jørgensen, KA1
van Delft, JL; van Haeringen, NJ; Verbey, NL1
Chilton, FH; Fonteh, AN; Hubbard, WC; Patel, M; Triggiani, M1
Akkerman, JW; Banga, JD; de Graaf, JC; Erkelens, DW; Sixma, JJ; van Breugel, HH; Westerveld, HT1
Fukumura, D; Imaeda, H; Kurose, I; Miura, S; Sekizuka, E; Serizawa, H; Shiozaki, H; Suematsu, M; Tashiro, H; Tsuchiya, M1
Keicher, U; Koletzko, B; Reinhardt, D1
Hata, N; Kobayashi, T; Misawa, Y; Ohhashi, K; Okuyama, H; Takahashi, T; Watanabe, S1
Grimminger, F; Kiss, L; Mayer, K; Seeger, W; Walmrath, D1
Hichami, A; Legrand, AB; Martin-Chouly, CA; Menier, V; Noel, F; Pedrono, F; Youmine, H1
Bieniek, E; Grandel, U; Grimminger, F; Kiss, L; Mayer, K; Rose, F; Seeger, W; Sibelius, U1
Bauer, JE; Horohov, DW; Hosgood, G; LeBlanc, CJ; Mauldin, GE1
Dona, M; Fredman, G; Irimia, D; Krishnamoorthy, S; Oh, SF; Serhan, CN1

Reviews

1 review(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and eicosapentaenoic acid

ArticleYear
Platelets and atherosclerosis.
    Advances in nutritional research, 1983, Volume: 5

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arteriosclerosis; Blood Platelets; Blood Vessels; Dietary Fats; Eicosapentaenoic Acid; Epoprostenol; Fatty Acids, Unsaturated; Hemostasis; Humans; Lipid Peroxides; Mitogens; Platelet Activating Factor; Platelet Aggregation; Thromboxanes

1983

Trials

3 trial(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and eicosapentaenoic acid

ArticleYear
The effect of eicosapentaenoic acid consumption on human neutrophil chemiluminescence.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Adult; Dietary Fats; Double-Blind Method; Eicosapentaenoic Acid; Female; Humans; Kinetics; Luminescent Measurements; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Olive Oil; Plant Oils; Platelet Activating Factor; Time Factors

1991
Effects of low-dose EPA-E on glycemic control, lipid profile, lipoprotein(a), platelet aggregation, viscosity, and platelet and vessel wall interaction in NIDDM.
    Diabetes care, 1993, Volume: 16, Issue:5

    Topics: Adenosine Diphosphate; Analysis of Variance; Blood Glucose; Blood Platelets; Blood Viscosity; Collagen; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blind Method; Eicosapentaenoic Acid; Endothelium, Vascular; Erythrocyte Deformability; Extracellular Matrix; Female; Humans; In Vitro Techniques; Lipoprotein(a); Male; Middle Aged; Platelet Activating Factor; Platelet Adhesiveness; Platelet Aggregation

1993
Resolvin E2 formation and impact in inflammation resolution.
    Journal of immunology (Baltimore, Md. : 1950), 2012, May-01, Volume: 188, Issue:9

    Topics: Animals; Chemotaxis; Down-Regulation; Eicosapentaenoic Acid; Female; Humans; Immunity, Innate; Inflammation; Integrins; Male; Mice; Neutrophils; Phagocytosis; Platelet Activating Factor

2012

Other Studies

17 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and eicosapentaenoic acid

ArticleYear
Evidence that increasing the cellular content of eicosapentaenoic acid does not reduce the biosynthesis of platelet-activating factor.
    Journal of immunology (Baltimore, Md. : 1950), 1990, Oct-01, Volume: 145, Issue:7

    Topics: Acylation; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Dietary Fats; Eicosapentaenoic Acid; Fish Oils; In Vitro Techniques; Mast Cells; Mice; Neutrophils; Phosphatidylcholines; Platelet Activating Factor

1990
Effects of a fish oil diet on the metabolism of endogenous (n-6) and (n-3) fatty acids in rat neutrophils.
    Biochimica et biophysica acta, 1990, Oct-22, Volume: 1047, Issue:1

    Topics: Acylation; Animals; Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Dietary Fats, Unsaturated; Eicosapentaenoic Acid; Fatty Acids; Fish Oils; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Male; Neutrophils; Phospholipids; Platelet Activating Factor; Rats; Rats, Inbred Strains

1990
The effect of long-term consumption of fish oil on platelet-activating factor synthesis in rat renal microsomes.
    Biochemical and biophysical research communications, 1989, May-15, Volume: 160, Issue:3

    Topics: Acetyl Coenzyme A; Acetyltransferases; Animals; Dietary Fats; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fish Oils; Glycerylphosphorylcholine; Kidney; Male; Microsomes; Plant Oils; Platelet Activating Factor; Rats; Rats, Inbred Strains; Sunflower Oil

1989
Can the synthesis of platelet-activating factor, a potent vasodilator and pro-aggregatory agent, be altered by dietary marine oils?
    Clinical and experimental pharmacology & physiology, 1987, Volume: 14, Issue:3

    Topics: Adult; Blood Platelets; Chromatography, Gas; Diet; Eicosapentaenoic Acid; Fatty Acids; Fish Oils; Humans; Male; Middle Aged; Phospholipids; Platelet Activating Factor; Platelet Aggregation; Thromboxane B2

1987
Reacylation of platelet activating factor with eicosapentaenoic acid in fish-oil-enriched monkey neutrophils.
    Biochimica et biophysica acta, 1987, Nov-21, Volume: 922, Issue:2

    Topics: Acylation; Animals; Eicosapentaenoic Acid; Fish Oils; Kinetics; Macaca fascicularis; Neutrophils; Platelet Activating Factor; Reference Values

1987
The effects of N-3 polyunsaturated fatty acids on the generation of platelet-activating factor-acether by human monocytes.
    Journal of immunology (Baltimore, Md. : 1950), 1987, Dec-15, Volume: 139, Issue:12

    Topics: Adult; Arachidonic Acid; Arachidonic Acids; Calcimycin; Dietary Fats; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fish Oils; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Platelet Activating Factor

1987
Effect of dietary fish oils on the formation of leukotriene B4 and B5, thromboxane and platelet activating factor by rat leukocytes.
    Clinical and experimental pharmacology & physiology, 1988, Volume: 15, Issue:7

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Diet; Eicosapentaenoic Acid; Fatty Acids; Fish Oils; In Vitro Techniques; Leukocytes; Leukotriene B4; Lipoxygenase; Male; Phospholipids; Platelet Activating Factor; Rats; Rats, Inbred Strains; Thromboxane B2; Thromboxanes

1988
The effect of endogenous eicosapentaenoic acid on PMN leukotriene and PAF biosynthesis.
    Prostaglandins, leukotrienes, and medicine, 1986, Volume: 23, Issue:2-3

    Topics: Animals; Diet; Eicosapentaenoic Acid; Fish Oils; Leukotriene B4; Neutrophils; Platelet Activating Factor; Rats

1986
Antagonists and inhibitors of lipid mediators in experimental inflammation of the cornea.
    Journal of ocular pharmacology, 1993,Winter, Volume: 9, Issue:4

    Topics: Animals; Chromones; Diterpenes; Eicosapentaenoic Acid; Fluorometholone; Ginkgolides; Keratitis; Lactones; Linolenic Acids; Lipids; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Rabbits; SRS-A; Suprofen

1993
Dietary n-3 fatty acid effects on neutrophil lipid composition and mediator production. Influence of duration and dosage.
    The Journal of clinical investigation, 1993, Volume: 91, Issue:1

    Topics: Adult; Dietary Fats; Dose-Response Relationship, Drug; Eicosapentaenoic Acid; Fatty Acids; Fatty Acids, Omega-3; Fish Oils; Humans; Kinetics; Leukotriene B4; Lipids; Male; Neutrophils; Phospholipids; Platelet Activating Factor; Reference Values; Time Factors

1993
Attenuation of endotoxin-induced intestinal microcirculatory damage by eicosapentanoic acid.
    The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 1

    Topics: Animals; Blood Flow Velocity; Cell Adhesion; Edema; Eicosapentaenoic Acid; Endotoxins; Erythrocytes; Escherichia coli; Fatty Acids; Ileum; Intestinal Mucosa; Leukocytes; Male; Microcirculation; Phospholipids; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Wistar; Venules

1993
Omega-3 fatty acids suppress the enhanced production of 5-lipoxygenase products from polymorph neutrophil granulocytes in cystic fibrosis.
    European journal of clinical investigation, 1995, Volume: 25, Issue:12

    Topics: Adolescent; Adult; Arachidonate 5-Lipoxygenase; Arachidonic Acids; Catechols; Child; Child, Preschool; Cystic Fibrosis; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Female; Fish Oils; Humans; Leukotrienes; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; Platelet Activating Factor; Tyrphostins

1995
Effect of replacing a high linoleate oil with a low linoleate, high alpha-linolenate oil, as compared with supplementing EPA or DHA, on reducing lipid mediator production in rat polymorphonuclear leukocytes.
    Biological & pharmaceutical bulletin, 1998, Volume: 21, Issue:6

    Topics: alpha-Linolenic Acid; Animals; Calcimycin; Dietary Fats, Unsaturated; Docosahexaenoic Acids; Eicosanoids; Eicosapentaenoic Acid; Ionophores; Linoleic Acid; Male; Neutrophils; Phospholipids; Plant Oils; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Safflower Oil

1998
PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in the isolated rabbit lung.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 278, Issue:2

    Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Capillaries; Cysteine; Drug Combinations; Eicosapentaenoic Acid; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Leukotrienes; Lung; Neutrophils; Platelet Activating Factor; Pulmonary Circulation; Rabbits

2000
Modulation of PAF production by incorporation of arachidonic acid and eicosapentaenoic acid in phospholipids of human leukemic monocyte-like cells THP-1.
    Prostaglandins & other lipid mediators, 2000, Volume: 60, Issue:4-6

    Topics: Acetates; Arachidonic Acid; Calcimycin; Eicosapentaenoic Acid; Humans; Ionophores; Leukemia, Monocytic, Acute; Phospholipids; Platelet Activating Factor; Tumor Cells, Cultured

2000
E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 279, Issue:1

    Topics: Animals; Eicosanoids; Eicosapentaenoic Acid; Escherichia coli; Hemolysin Proteins; Hydroxyeicosatetraenoic Acids; Inflammation Mediators; Leukotriene B4; Lipid Metabolism; Lipoxygenase Inhibitors; Macrophages, Alveolar; Platelet Activating Factor; Rabbits

2000
Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs.
    American journal of veterinary research, 2008, Volume: 69, Issue:4

    Topics: Animals; Area Under Curve; Cytokines; Dietary Supplements; Dinoprostone; Docosahexaenoic Acids; Dogs; Eicosapentaenoic Acid; Female; Interleukin-1; Interleukin-6; Male; Platelet Activating Factor; Random Allocation; Tumor Necrosis Factor-alpha; Vitamin E

2008