1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with edelfosine in 28 studies
| Studies (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Trials (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Recent Studies (post-2010) (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Studies (edelfosine) | Trials (edelfosine) | Recent Studies (post-2010) (edelfosine) |
|---|---|---|---|---|---|
| 9,156 | 187 | 552 | 454 | 7 | 85 |
| Protein | Taxonomy | 1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50) | edelfosine (IC50) |
|---|---|---|---|
| Platelet-activating factor receptor | Cavia porcellus (domestic guinea pig) | 1.8 | |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | 3.5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (39.29) | 18.7374 |
| 1990's | 13 (46.43) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 2 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Donaldson, J; Lohmeyer, M; Workman, P | 1 |
| Brohult, J; Palmblad, J; Samuelsson, J | 1 |
| Bazill, GW; Dexter, TM | 2 |
| Debs, RA; Philip, R; Rose, JK; Ruis, NM; Valone, FH | 1 |
| Kosano, H; Takatani, O | 1 |
| Daniel, LW; Schmitt, JD; Wilcox, RW; Wykle, RL | 1 |
| Chang, HW; Hayashi, H; Inoue, K; Kondo, E; Kudo, I; Nojima, S; Nomura, H; Yanoshita, R | 1 |
| Eibl, H; Nagel, GA; Söling, U; Unger, C | 1 |
| Berdel, WE; Eibl, H; Fink, U; Fromm, M; Jehn, U; Rastetter, J; Reichert, A; Schick, HD; Ulm, K; Unger, C | 1 |
| Berdel, WE; Busch, R; Danhauser, S; Eibl, H; Fink, U; Fromm, M; Rastetter, J; Reichert, A; Schick, HD | 1 |
| Hoffman, DR; Hoffman, LH; Snyder, F | 1 |
| Cordeiro, RS; Henriques, MG; Martins, MA; Silva, PM; Vargaftig, BB | 1 |
| Ferber, E; Herrmann, DB; Munder, PG | 1 |
| Andreesen, R; Costabel, U; Löhr, GW; Luckenbach, GA; Munder, PG; Osterholz, J; Schulz, A; Speth, V | 1 |
| Amico, C; Belluardo, N; Bindoni, M; Condorelli, DF; Dell' Albani, P; Mudò, G | 1 |
| Bindoni, M; Cardile, V; Jiang, X; Renis, M | 1 |
| Lin, S; Makriyannis, A; Moring, J; Xie, X | 1 |
| Bindoni, M; Cardile, V; De Simoni, MG; Jiang, X; Mascarucci, P | 1 |
| Bjerve, KS; Bleivik, B; White, LR | 1 |
| Benito, A; Fernández-Luna, JL; Gajate, C; Martín-Martín, B; Martínez-Dalmau, R; Modolell, M; Mollinedo, F | 1 |
| Alonso, MT; Alvarez, J; Gajate, C; García-Sancho, J; Modolell, M; Mollinedo, F | 1 |
| Makriyannis, A; Moring, J; Xie, XQ | 1 |
| Campisi, A; Cardile, V; Collovà, F; Renis, M; Russo, A | 1 |
| Grosman, N | 1 |
| Bahnson, BJ; Berg, OG; Jain, MK; Pan, YH; Yu, BZ | 1 |
| Danker, K; Klein, A; Semini, G | 1 |
| Dynarowicz-Łątka, P; Flasiński, M; Hąc-Wydro, K; Wydro, P | 1 |
28 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and edelfosine
| Article | Year |
|---|---|
Platelet-activating factor (PAF) antagonist WEB 2086 does not modulate the cytotoxicity of PAF or antitumour alkyl lysophospholipids ET-18-O-methyl and SRI 62-834 in HL-60 promyelocytic leukaemia cells.
Topics: Antineoplastic Agents; Azepines; Calcium; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Furans; Humans; Leukemia, Promyelocytic, Acute; Phospholipid Ethers; Platelet Activating Factor; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured | 1991 |
Interactions between alkylglycerols and human neutrophil granulocytes.
Topics: Calcium; Cytochrome c Group; Glyceryl Ethers; Humans; Kinetics; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidation-Reduction; Phospholipid Ethers; Platelet Activating Factor | 1990 |
Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Survival; Chloroquine; Diltiazem; Drug Synergism; Endocytosis; Furans; Humans; Hydroxyzine; In Vitro Techniques; Leukemia, Myeloid; Mice; Nifedipine; Phospholipid Ethers; Platelet Activating Factor; Pyridines; Quinidine; Quinine; Sodium Fluoride; Thiazoles; Triazoles; Verapamil | 1990 |
Selective activation of human monocytes by the platelet-activating factor analog 1-O-hexadecyl-2-O-methyl-sn-glycero-3-phosphorylcholine.
Topics: Cell Survival; Cytotoxicity, Immunologic; Glucuronidase; Humans; In Vitro Techniques; Monocytes; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Tumor Necrosis Factor-alpha | 1990 |
An antagonist to platelet activating factor counteracts the tumoricidal action of alkyl lysophospholipids.
Topics: Biological Transport; Cell Survival; Furans; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tumor Cells, Cultured | 1989 |
Reduction of epidermal growth factor binding in human breast cancer cell lines by an alkyl-lysophospholipid.
Topics: Antineoplastic Agents; Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Phosphatidylcholines; Phospholipid Ethers; Platelet Activating Factor; Protein Kinase C; Tumor Cells, Cultured | 1988 |
The degradation of platelet-activating factor and related lipids: susceptibility to phospholipases C and D.
Topics: Animals; Antineoplastic Agents; Humans; Phospholipase D; Phospholipases; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Tumor Cells, Cultured; Type C Phospholipases | 1987 |
Antitumor activity of synthetic alkylphospholipids with or without PAF activity.
Topics: Animals; Antineoplastic Agents; Cell Line; Female; Injections, Intravenous; Mice; Mice, Inbred C3H; Mice, Inbred ICR; Molecular Conformation; Phospholipid Ethers; Platelet Activating Factor; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1987 |
Effect of synthetic phospholipids on platelet aggregation and serotonin release.
Topics: Blood Platelets; Humans; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Serotonin | 1987 |
Cytotoxic effects of ether lipids and derivatives in human nonneoplastic bone marrow cells and leukemic cells in vitro.
Topics: Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cell Survival; Cytotoxins; Humans; Leukemia; Organophosphates; Phospholipid Ethers; Platelet Activating Factor; Thymidine; Tumor Cells, Cultured | 1987 |
Structure-cytotoxicity studies on alkyl lysophospholipids and some analogs in leukemic blasts of human origin in vitro.
Topics: Antineoplastic Agents; Cell Survival; Cytotoxins; Glyceryl Ethers; Humans; Leukemia; Lysophospholipids; Organophosphates; Phospholipid Ethers; Platelet Activating Factor; Tumor Cells, Cultured | 1987 |
Cytotoxicity and metabolism of alkyl phospholipid analogues in neoplastic cells.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Membrane; Dogs; Humans; Lysophosphatidylcholines; Microsomes, Liver; Mixed Function Oxygenases; Phospholipid Ethers; Platelet Activating Factor; Rats; Substrate Specificity | 1986 |
Platelet involvement in rat paw edema induced by 2-methoxy-PAF.
Topics: Animals; Blood Platelets; Edema; Female; Lysophosphatidylcholines; Male; Phospholipid Ethers; Platelet Activating Factor; Rabbits; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Ether phospholipids as inhibitors of the arachidonoyl-CoA: 1-acyl-sn-glycero-3-phosphocholine acyltransferase in macrophages.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Acyl Coenzyme A; Acylation; Acyltransferases; Animals; Dose-Response Relationship, Drug; Female; Kinetics; Lysophosphatidylcholines; Macrophages; Mice; Phospholipid Ethers; Phospholipids; Platelet Activating Factor | 1986 |
Tumor cytotoxicity of human macrophages after incubation with synthetic analogues of 2-lysophosphatidylcholine.
Topics: Antineoplastic Agents; Cell Line; Cytotoxicity, Immunologic; Humans; In Vitro Techniques; Lymphoma; Lysophosphatidylcholines; Macrophage Activation; Macrophages; Phospholipid Ethers; Platelet Activating Factor | 1984 |
Platelet-activating factor and its methoxy-analogue ET-18-OCH3 stimulate immediate early gene expression in rat astroglial cultures.
Topics: Animals; Astrocytes; Cells, Cultured; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression; Genes, fos; Immediate-Early Proteins; Phospholipid Ethers; Platelet Activating Factor; Rats; RNA, Messenger; Transcription Factors | 1993 |
Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero- 3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes.
Topics: Animals; Antineoplastic Agents; Astrocytes; Azepines; Cells, Cultured; Citrulline; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Immunohistochemistry; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Stimulation, Chemical; Thienopyridines; Triazoles | 1996 |
Interdigitation of bilayers from ether lipid analogs: (R)-PAF, (R)-Lyso-PAF and the antineoplastic (R)-ET-18-OMe.
Topics: Antineoplastic Agents; Calorimetry, Differential Scanning; Lipid Bilayers; Phospholipid Ethers; Platelet Activating Factor; Thermodynamics; X-Ray Diffraction | 1996 |
The effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and its analogues platelet activating factor and carbamyl-platelet activating factor on the biosynthesis of interleukin-6 in human thymic epithelial cells cultivated in vitro
Topics: Azepines; Cells, Cultured; Dose-Response Relationship, Drug; Epithelium; Humans; Interleukin-6; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Thymus Gland; Triazoles | 1996 |
Protein kinase C inhibitors and PAF stimulate phosphatidylserine synthesis in human leucocytes.
Topics: Antineoplastic Agents; Carbon Radioisotopes; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Male; Neutrophils; Phosphatidylserines; Phospholipid Ethers; Platelet Activating Factor; Protein Kinase C; Serine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1996 |
Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L).
Topics: Albumins; Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Gene Expression; Genes, bcl-2; Humans; Lymphocytes; Mice; Monocytes; Phospholipid Ethers; Platelet Activating Factor; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Suramin; Tumor Cells, Cultured | 1997 |
Dissociation of the effects of the antitumour ether lipid ET-18-OCH3 on cytosolic calcium and on apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Calcium; Cytosol; HL-60 Cells; Humans; Phospholipid Ethers; Platelet Activating Factor | 1997 |
Differential scanning calorimetry and small angle x-ray diffraction study of the interaction of (R)-PAF, (R)-ET-18-OME and (R)-Lyso-PAF with model membranes.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Antineoplastic Agents; Calorimetry, Differential Scanning; Dimyristoylphosphatidylcholine; Inflammation Mediators; Lipid Bilayers; Membranes, Artificial; Phospholipid Ethers; Platelet Activating Factor; Stereoisomerism; Temperature; X-Ray Diffraction | 1997 |
Glutamine synthetase activity and HSP70 levels in cultured rat astrocytes: effect of 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine.
Topics: Analysis of Variance; Animals; Astrocytes; Cells, Cultured; Conserved Sequence; DNA Fragmentation; Glutamate-Ammonia Ligase; HSP70 Heat-Shock Proteins; L-Lactate Dehydrogenase; Molecular Weight; Nerve Tissue Proteins; Oxidative Stress; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Wistar | 1998 |
Similar effects of ether phospholipids, PAF and lyso-PAF on the Ca(2+)-ATPase activity of rat brain synaptosomes and leukocyte membranes.
Topics: Animals; Calcium-Transporting ATPases; Cell Membrane; In Vitro Techniques; Inflammation Mediators; Leukocytes; Male; Membranes; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phospholipids; Platelet Activating Factor; Rats; Synaptosomes | 2001 |
Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive.
Topics: Animals; Anions; Binding Sites; Catalysis; Crystallization; Crystallography, X-Ray; Dimerization; Histidine; Hydrolysis; Ligands; Phospholipases A; Phospholipases A2; Phospholipid Ethers; Platelet Activating Factor; Protein Binding; Protein Structure, Tertiary; Protein Subunits; Spectrometry, Fluorescence; Substrate Specificity; Swine | 2002 |
Impact of alkylphospholipids on the gene expression profile of HaCaT cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Line; Cell Membrane; Cell Movement; Cell Proliferation; Gene Expression Profiling; Humans; Immunity, Innate; Keratinocytes; Neoplasms; Oligonucleotide Array Sequence Analysis; Phospholipid Ethers; Platelet Activating Factor; Transcription, Genetic | 2011 |
Influence of platelet-activating factor, lyso-platelet-activating factor and edelfosine on Langmuir monolayers imitating plasma membranes of cell lines differing in susceptibility to anti-cancer treatment: the effect of plasmalogen level.
Topics: Antineoplastic Agents; Cell Membrane; HL-60 Cells; Humans; K562 Cells; Membranes, Artificial; Neoplasms; Phospholipid Ethers; Plasmalogens; Platelet Activating Factor | 2014 |