1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with bw-755c in 29 studies
| Studies (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Trials (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Recent Studies (post-2010) (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Studies (bw-755c) | Trials (bw-755c) | Recent Studies (post-2010) (bw-755c) |
|---|---|---|---|---|---|
| 9,156 | 187 | 552 | 462 | 0 | 0 |
| Protein | Taxonomy | 1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50) | bw-755c (IC50) |
|---|---|---|---|
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | 3 | |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | 2.4237 | |
| Cytochrome P450 11B1, mitochondrial | Rattus norvegicus (Norway rat) | 5 | |
| Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Norway rat) | 5 | |
| Sodium- and chloride-dependent GABA transporter 2 | Rattus norvegicus (Norway rat) | 5 | |
| Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Norway rat) | 5 | |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | 5.5 | |
| Sodium- and chloride-dependent betaine transporter | Rattus norvegicus (Norway rat) | 5 | |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | 5.5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (72.41) | 18.7374 |
| 1990's | 8 (27.59) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amorim, CZ; Cordeiro, RS; Henriques, MG; Vargaftig, BB; Weg, VB | 1 |
| Furman, BL; Gray, GA; Parratt, JR | 1 |
| Bozza, PT; Cordeiro, RS; Faria Neto, HC; Martins, MA; Pasquale, CP; Pires, AL; Silva, PM | 1 |
| Cordeiro, RS; e Silva, PM; Martins, MA; Pasquale, CP; Vargaftig, BB | 1 |
| Myers, AK; Price, RM; Robey, JW | 1 |
| Lefkowith, JB; Rovin, BH; Schreiner, GF | 1 |
| Dumarey, C; Lefort, J; Pretolani, M; Vargaftig, BB | 1 |
| Browning, JL; Cirino, G; Flower, RJ; Peers, SH; Pepinsky, RB | 1 |
| Boughton-Smith, NK; Hutcheson, I; Whittle, BJ | 1 |
| Fitzgerald, MF; Parente, L; Whittle, BJ | 1 |
| Anderson, GP; Fennessy, MR | 1 |
| Dejana, E; Prosdocimi, M; Zanetti, A; Zatta, A | 1 |
| Issekutz, AC; Ripley, M; Rochon, Y | 1 |
| Moodley, I; Stuttle, A | 1 |
| Darius, H; Lefer, AM; Lefer, DJ; Smith, JB | 1 |
| Altman, R; Scazziota, A | 1 |
| Wallace, JL; Whittle, BJ | 1 |
| Barnes, PJ; Chung, KF; Evans, TW; Rogers, DF | 1 |
| Imura, Y; Nishikawa, K; Shino, A; Terashita, Z | 1 |
| Darius, H; Lefer, AM | 1 |
| Abbate, M; Bertani, T; Cucchi, M; Delaini, F; Perico, N; Remuzzi, G; Tagliaferri, M | 1 |
| Acker, G; Braquet, P; Etienne, A; Hecquet, F; Mencia-Huerta, JM | 1 |
| Peers, SH | 1 |
| Anderson, GP; Fennessy, MR; White, HL | 1 |
| Cloutier, S; Jancar, S; Provençal, B; Sirois, P; Thériault, P | 1 |
| Baum, T; Pula, K; Rivelli, M; Sybertz, EJ; Watkins, RW | 1 |
| Barth, T; Bekemeier, H; Hänsel, F; Hirschelmann, R; Sänze, JU | 1 |
| Becker, I; Huber, W; Peskar, BM; Schenck, U; Schepp, W; Trautmann, M | 1 |
| Becker, K; Förster, W; Grupe, R; Lueddeckens, G | 1 |
29 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and bw-755c
| Article | Year |
|---|---|
Effect of PAF-acether antagonists on active anaphylactic mouse paw edema.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Anaphylaxis; Animals; Aspirin; Azepines; Cimetidine; Dexamethasone; Edema; Male; Meclizine; Methysergide; Mice; Ovalbumin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prednisolone; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetrazoles; Triazoles | 1991 |
Endotoxin-induced impairment of vascular reactivity in the pithed rat: role of arachidonic acid metabolites.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Cyclooxygenase Inhibitors; Dinoprostone; Electric Stimulation; Endotoxins; Epoprostenol; Flurbiprofen; Hemodynamics; Iloprost; Male; Norepinephrine; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Spinal Cord; Sympathetic Nervous System | 1990 |
Bradykinin induces eosinophil accumulation in the rat pleural cavity.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Benzeneacetamides; Bradykinin; Cell Movement; Chemotaxis; Diterpenes; Dose-Response Relationship, Drug; Eosinophilia; Female; Ginkgolides; Hydroxamic Acids; Injections, Intraperitoneal; Lactones; Lipoxygenase Inhibitors; Male; Neutrophils; Platelet Activating Factor; Pleura; Pleurisy; Rats; Rats, Inbred Strains | 1991 |
Eosinophil accumulation in the rat pleural cavity after mast cell stimulation with compound 48/80 involves protein synthesis and is selectively suppressed by dexamethasone.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Azepines; Cycloheximide; Dexamethasone; Eosinophils; Female; Leukocyte Count; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Platelet Activating Factor; Pleura; Protein Biosynthesis; Rats; Rats, Inbred Strains; Triazoles | 1990 |
Relationships between tumour necrosis factor, eicosanoids and platelet-activating factor as mediators of endotoxin-induced shock in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Capillary Permeability; Diterpenes; Drug Interactions; Eicosanoids; Endotoxins; Escherichia coli; Female; Ginkgolides; Hematocrit; Indomethacin; Lactones; Mice; Platelet Activating Factor; Recombinant Proteins; Shock, Septic; Tumor Necrosis Factor-alpha | 1990 |
Mechanisms underlying the anti-inflammatory effects of essential fatty acid deficiency in experimental glomerulonephritis. Inhibited release of a monocyte chemoattractant by glomeruli.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Chemotactic Factors; Eicosanoids; Fatty Acids, Essential; Glomerulonephritis; Kidney Glomerulus; Macrophages; Male; Monocytes; Platelet Activating Factor; Rats; Rats, Inbred Lew | 1990 |
Role of lipoxygenase metabolites for the hyper-responsiveness to platelet-activating factor of lungs from actively sensitized guinea pigs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Female; Guinea Pigs; Histamine Release; Immunization; Immunoglobulins; Kinetics; Lipoxygenase; Lung; Male; Platelet Activating Factor; Pyrazoles; SRS-A; Trachea | 1989 |
Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adrenalectomy; Animals; Annexins; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Carrageenan; Dexamethasone; Dextrans; Edema; Glycoproteins; Indomethacin; Male; Methotrexate; p-Methoxy-N-methylphenethylamine; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Pyrazoles; Rats; Rats, Inbred Strains; Recombinant Proteins; Serotonin | 1989 |
Relationship between PAF-acether and thromboxane A2 biosynthesis in endotoxin-induced intestinal damage in the rat.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Escherichia coli; Ethanol; Imidazoles; Indomethacin; Jejunum; Lipopolysaccharides; Male; Methacrylates; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred Strains; Shock, Septic; Thromboxane A2; Thromboxane-A Synthase | 1989 |
Release of PAF-acether and eicosanoids from guinea-pig alveolar macrophages by FMLP: effect of cyclo-oxygenase and lipoxygenase inhibition.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate Lipoxygenases; Benzeneacetamides; Cyclooxygenase Inhibitors; Guinea Pigs; Hydroxamic Acids; In Vitro Techniques; Indomethacin; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pulmonary Alveoli; Pyrazoles; Radioimmunoassay; Thromboxane B2 | 1989 |
Lipoxygenase metabolites mediate increased airways responsiveness to histamine after acute platelet activating factor exposure in the guinea-pig.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Airway Resistance; Animals; Aspirin; Bronchi; Chromones; Female; Guinea Pigs; Histamine; Leukotriene B4; Lipoxygenase; Lung Compliance; Male; Platelet Activating Factor; Pyrazoles; Quinolinium Compounds; SRS-A | 1988 |
The effect of AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxy- carbonylmethoxycoumarin) on washed human platelet aggregation induced by platelet activating factor (PAF) and epinephrine.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Aspirin; beta-Thromboglobulin; Blood Platelets; Chromonar; Coumarins; Drug Interactions; Epinephrine; Humans; In Vitro Techniques; Masoprocol; Platelet Activating Factor; Platelet Aggregation; Pyrazoles | 1986 |
Synergistic inhibition of complement induced granulocyte margination by BW755C and calcium channel blockers.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Agranulocytosis; Animals; Calcium; Calcium Channel Blockers; Cell Aggregation; Chemotactic Factors; Complement System Proteins; Female; Granulocytes; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pyrazoles; Rabbits; Verapamil | 1985 |
Evidence for a dual pathway in platelet activating factor-induced aggregation of rat polymorphonuclear leucocytes.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Cell Aggregation; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Neutrophils; Platelet Activating Factor; Pyrazoles; Pyrazolones; Rats; Rats, Inbred Strains | 1987 |
Role of platelet-activating factor-acether in mediating guinea pig anaphylaxis.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Alprazolam; Anaphylaxis; Animals; Anti-Inflammatory Agents; Benzodiazepines; Blood Pressure; Diphenhydramine; Guinea Pigs; In Vitro Techniques; Kinetics; Lung; Male; Ovalbumin; Platelet Activating Factor; Platelet Count; Pyrazoles | 1986 |
Synergistic actions of paf-acether and sodium arachidonate in human platelet aggregation. 2. Unexpected results after aspirin intake.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adenosine; Administration, Oral; Adult; Apyrase; Arachidonic Acids; Aspirin; Catechols; Drug Synergism; Epoprostenol; Humans; Indomethacin; Masoprocol; Platelet Activating Factor; Platelet Aggregation; Pyrazoles; Thromboxane B2; Time Factors; Umbelliferones | 1986 |
Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentration.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Pressure; Dexamethasone; Gastric Mucosa; Hematocrit; Male; Necrosis; Platelet Activating Factor; Prednisolone; Pyrazoles; Rats; Rats, Inbred Strains | 1986 |
Effect of platelet-activating factor on airway vascular permeability: possible mechanisms.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Biomechanical Phenomena; Capillary Permeability; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Lactones; Male; Plant Extracts; Platelet Activating Factor; Platelet Count; Pyrazoles; Respiratory System; Time Factors | 1987 |
A lethal role of platelet activating factor in anaphylactic shock in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromones; Dexamethasone; Male; Mice; Mice, Inbred Strains; Naloxone; Phospholipid Ethers; Platelet Activating Factor; Pyrazoles; SRS-A; Thiazoles | 1987 |
Pharmacologic antagonism of platelet activating factor and peptide leukotrienes inhibits guinea pig anaphylaxis.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Blood Pressure; Diphenhydramine; Guinea Pigs; In Vitro Techniques; Lignans; Lung; Male; Platelet Activating Factor; Platelet Count; Pyrazoles | 1987 |
Effect of platelet-activating factor and its specific receptor antagonist on glomerular permeability to proteins in isolated perfused rat kidney.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Antioxidants; Basement Membrane; Cell Membrane Permeability; Cyclooxygenase Inhibitors; Furans; Glomerular Filtration Rate; Indomethacin; Kidney Glomerulus; Lipoxygenase Inhibitors; Male; Microscopy, Electron; Perfusion; Phenothiazines; Platelet Activating Factor; Proteins; Proteinuria; Pyrazoles; Rats; Rats, Inbred Strains; Vascular Resistance | 1988 |
Role of platelet-activating factor (PAF) in the ovoimplantation in the rat: effect of the specific PAF-acether antagonist, BN 52021.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Catechols; Diterpenes; Dose-Response Relationship, Drug; Embryo Implantation; Female; Ginkgolides; Indomethacin; Kinetics; Lactones; Lipoxygenase Inhibitors; Masoprocol; Platelet Activating Factor; Pyrazoles; Rats; Rats, Inbred Strains; Sulfides | 1988 |
Dexamethasone inhibits platelet activating factor-induced inflammation in the paw but not the pleural cavity of rats.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Dexamethasone; Edema; Female; Foot; Indomethacin; Inflammation; Male; Platelet Activating Factor; Pleura; Pyrazoles; Rats; Rats, Inbred Strains | 1988 |
Increased airways responsiveness to histamine induced by platelet activating factor in the guinea-pig: possible role of lipoxygenase metabolites.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Aspirin; Atropine Derivatives; Bronchi; Female; Guinea Pigs; Histamine; Indomethacin; Lipoxygenase; Male; Masoprocol; Platelet Activating Factor; Pyrazoles; Vagotomy | 1988 |
Mechanism of action of platelet-activating factor on guinea-pig lung parenchyma strips.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Guinea Pigs; Immunoenzyme Techniques; Lung; Masoprocol; Methacrylates; Muscle Contraction; Platelet Activating Factor; Pyrazoles; Sulfonamides; Thromboxane A2; Thromboxane B2 | 1988 |
Cardiac, coronary and peripheral vascular effects of acetyl glyceryl ether phosphoryl choline in the anesthetized dog.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Blood Pressure; Coronary Circulation; Dogs; Extremities; Female; Heart; Heart Rate; Hexamethonium Compounds; Indomethacin; Male; Myocardial Contraction; Platelet Activating Factor; Pyrazoles; Regional Blood Flow; Theophylline; Vagotomy; Vasodilation | 1985 |
On the nature of the vasoreactivity depressing factor (VDF) in inflammation and anaphylaxis in the rat and mouse.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Alprostadil; Anaphylaxis; Animals; Anti-Inflammatory Agents; Epoprostenol; Female; Histamine; Indomethacin; Inflammation; Male; Mice; Mice, Inbred Strains; Norepinephrine; Platelet Activating Factor; Prostaglandins E; Pyrazoles; Rats; Rats, Inbred Strains; Serotonin; Vasopressins | 1984 |
Leukotriene B4 and C4 production in isolated rat gastric mucosal cells.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Bucladesine; Calcimycin; Cell Separation; Colforsin; Diglycerides; Female; Gastric Mucosa; Histamine; In Vitro Techniques; Interleukin-1; Interleukin-2; Kinetics; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Pentagastrin; Phenothiazines; Platelet Activating Factor; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1993 |
PAF-induced death in NMRI mice--a suitable shock model for testing new PAF receptor antagonists. Correlation with eicosanoid related substances.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Azepines; Disease Models, Animal; Diterpenes; Eicosanoids; Female; Ginkgolides; Lactones; Masoprocol; Mice; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock; Species Specificity; Triazoles | 1993 |