Page last updated: 2024-09-02

1-hexadecyl-2-acetyl-glycero-3-phosphocholine and atropine

1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with atropine in 23 studies

Compound Research Comparison

Studies
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Trials
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Recent Studies (post-2010)
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010) (atropine)
9,15618755226,7111,2591,697

Protein Interaction Comparison

ProteinTaxonomy1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50)atropine (IC50)
cystic fibrosis transmembrane conductance regulatorHomo sapiens (human)21.41
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)1.012
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.0067
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.0007
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.001
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.001
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.001
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.001
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.0009
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.001
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.0015
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.0021
Alpha-1D adrenergic receptorHomo sapiens (human)1.354
5-hydroxytryptamine receptor 2CHomo sapiens (human)1.012

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199015 (65.22)18.7374
1990's7 (30.43)18.2507
2000's1 (4.35)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dohi, T; Kitayama, S; Morita, K; Tsujimoto, A1
Krell, RD; McCarthy, M1
Hamano, S; Ikeda, S; Kikuchi, S; Komatsu, H; Okegawa, T; Takehana, Y1
Kristersson, A; Mazzoni, L; Morley, J; Sanjar, S; Schaeublin, E1
Goswami, SK; Marom, ZM; Ohashi, M; Stathas, P1
Blake, JS; Leff, AR; Mack, MM; Moss, J; Munoz, NM; Murphy, TM1
Leff, AR; Munoz, NM; Popovich, KJ; Shioya, T; Stimler-Gerard, NP; White, SR1
Balázs, C; Fachet, J; Kiss, E; Nigam, S; Sipka, S; Szegedi, G1
Fischer, JJ; Rohrbach, MS; Rolstad, RA; Russell, JA1
Del Monte, M; Subissi, A1
Blake, J; Denberg, P; Leff, AR; Mack, M; Munoz, NM; Popovich, KJ; Sheldon, G; White, SR1
Bosia, A; Braquet, P; Bussolino, F; Camussi, G; Prosdocimi, M; Tessari, F; Turrini, F1
Patterson, R; Rubin, AH; Smith, LJ1
Okamoto, M; Terao, M; Tokumura, A; Tsukatani, H; Yoshida, K1
Levy, JV1
Chand, N; Diamantis, W; Mahoney, TP; Sofia, RD1
Cutcher, A; Dunn, AM; Halonen, M; Holmes, T; Palmer, JD; Smith, PF1
Stimler-Gerard, NP1
Arnoux, B; Benveniste, J; Denjean, A; Lockhart, A; Masse, R1
Howell, RE; Kovalsky, MP; Laemont, KD1
Kawazoe, Y; Mizuta, H; Sagara, K; Shibata, M; Yamada, I1
Fujimura, K; Miwa, M; Saito, K; Sugatani, J1
Ishii, S; Nagase, T; Ouchi, Y; Shimizu, T; Shindou, H1

Other Studies

23 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and atropine

ArticleYear
Calcium-dependent biosynthesis of platelet-activating factor by submandibular gland cells.
    The Biochemical journal, 1991, May-15, Volume: 276 ( Pt 1)

    Topics: Acetylcholine; Acetyltransferases; Animals; Arachidonic Acid; Arachidonic Acids; Atropine; Calcium; Diacylglycerol Cholinephosphotransferase; Dithiothreitol; Dogs; Female; In Vitro Techniques; Kinetics; Male; Pirenzepine; Platelet Activating Factor; Submandibular Gland

1991
Pharmacologic analysis of platelet activating factor16- and 18-induced bronchoconstriction in the guinea pig.
    Annals of the New York Academy of Sciences, 1991, Volume: 629

    Topics: Animals; Atropine; Bronchoconstriction; Capsaicin; Captopril; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Leukocyte Count; Lung; Male; Methysergide; Platelet Activating Factor; Platelet Count; Propranolol; Pyrilamine; Respiratory Function Tests; Thiorphan

1991
Inhibitory action of OKY-O46.HCl, a specific TXA2 synthetase inhibitor, on platelet activating factor (PAF)-induced airway hyperresponsiveness of guinea pigs: role of TXA2 in development of PAF-induced nonspecific airway hyperresponsiveness.
    Japanese journal of pharmacology, 1990, Volume: 52, Issue:4

    Topics: Acrylates; Animals; Atropine; Autonomic Nervous System; Calcium Radioisotopes; Guinea Pigs; Hemicholinium 3; Hexamethonium Compounds; Kinetics; Male; Methacrylates; Platelet Activating Factor; Receptors, Adrenergic, beta; Receptors, Muscarinic; Respiratory System; Thromboxane A2; Thromboxane-A Synthase

1990
Increased airway reactivity in the guinea-pig follows exposure to intravenous isoprenaline.
    The Journal of physiology, 1990, Volume: 425

    Topics: Airway Resistance; Animals; Atropine; Blood Platelets; Bombesin; Bronchodilator Agents; Colforsin; Dopamine; Epinephrine; Guinea Pigs; Histamine; Injections, Intravenous; Isoproterenol; Male; Norepinephrine; Platelet Activating Factor; Propranolol; Rabbits; Vagotomy; Vagus Nerve

1990
Platelet-activating factor stimulates secretion of respiratory glycoconjugate from human airways in culture.
    The Journal of allergy and clinical immunology, 1989, Volume: 84, Issue:5 Pt 1

    Topics: Arachidonic Acids; Atropine; Bronchi; Culture Techniques; Cyclooxygenase Inhibitors; Dexamethasone; Dose-Response Relationship, Drug; Glyceryl Ethers; Glycoconjugates; Histamine Release; Humans; Leukotrienes; Lipoxygenase Inhibitors; Mucous Membrane; Platelet Activating Factor; Thiazoles; Time Factors

1989
PAF-induced contraction of canine trachea mediated by 5-hydroxytryptamine in vivo.
    Journal of applied physiology (Bethesda, Md. : 1985), 1989, Volume: 66, Issue:2

    Topics: Animals; Atropine; Dogs; Histamine; Muscle Contraction; Parasympathetic Nervous System; Platelet Activating Factor; Serotonin; Trachea

1989
Parasympathetic involvement in PAF-induced contraction in canine trachealis in vivo.
    Journal of applied physiology (Bethesda, Md. : 1985), 1987, Volume: 62, Issue:2

    Topics: Animals; Atropine; Biomechanical Phenomena; Chlorpheniramine; Dogs; Dose-Response Relationship, Drug; Female; Hexamethonium; Hexamethonium Compounds; Indomethacin; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Parasympathetic Nervous System; Platelet Activating Factor; Reference Values; Trachea

1987
Atropine is an inhibitor of the chemiluminescence induced by platelet-activating factor in human neutrophils.
    Acta biochimica et biophysica Hungarica, 1987, Volume: 22, Issue:4

    Topics: Atropine; Humans; Kinetics; Luminescent Measurements; Neutrophils; Platelet Activating Factor

1987
Changes in the levels of bioactive components of cotton bracts accompanying senescence.
    Lung, 1988, Volume: 166, Issue:3

    Topics: Animals; Atropine; Blood Platelets; Dogs; Endotoxins; Gossypium; Humans; In Vitro Techniques; Methysergide; Muscle Contraction; Muscle, Smooth; Plant Extracts; Platelet Activating Factor; Serotonin; Spectrophotometry; Tannins; Time Factors

1988
Platelet-activating factor-induced contraction of guinea-pig lung parenchymal strips: possible involvement of arachidonate metabolites.
    Naunyn-Schmiedeberg's archives of pharmacology, 1988, Volume: 338, Issue:4

    Topics: Acetylcholine; Animals; Arachidonic Acids; Atropine; Azepines; Cyclooxygenase Inhibitors; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Lipoxygenase Inhibitors; Lung; Male; Muscle Contraction; Muscle, Smooth; Platelet Activating Factor; Thromboxane A2; Triazines; Triazoles

1988
Role of platelets in contraction of canine tracheal muscle elicited by PAF in vitro.
    Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:2

    Topics: Animals; Atropine; Blood Platelets; Dogs; Female; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Phospholipid Ethers; Platelet Activating Factor; Serotonin; Tachyphylaxis; Trachea

1988
Platelet activating factor induces dopamine release in PC-12 cell line.
    The American journal of physiology, 1988, Volume: 255, Issue:4 Pt 1

    Topics: Adrenal Gland Neoplasms; Animals; Atropine; Calcium; Carbachol; Cell Line; Diterpenes; Dopamine; Ginkgolides; Kinetics; Lactones; Pheochromocytoma; Phospholipid Ethers; Platelet Activating Factor

1988
Mechanism of platelet activating factor-induced bronchoconstriction in humans.
    The American review of respiratory disease, 1988, Volume: 137, Issue:5

    Topics: Adolescent; Adult; Asthma; Atropine; Bronchi; Bronchial Provocation Tests; Chlorpheniramine; Dose-Response Relationship, Drug; Humans; Indomethacin; Platelet Activating Factor; Respiratory Function Tests

1988
Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis.
    European journal of pharmacology, 1988, Apr-13, Volume: 148, Issue:3

    Topics: Animals; Atropine; Chlorpheniramine; Chromones; Colon; In Vitro Techniques; Indomethacin; Male; Methysergide; Muscle Contraction; Platelet Activating Factor; Rats; Rats, Inbred Strains; Serum Albumin; SRS-A; Tachyphylaxis

1988
Spasmogenic effect of platelet activating factor (PAF) on isolated rat stomach fundus strip.
    Biochemical and biophysical research communications, 1987, Jul-31, Volume: 146, Issue:2

    Topics: Acetylcholine; Animals; Atropine; Dose-Response Relationship, Drug; Female; Gastric Fundus; Male; Muscle Contraction; Platelet Activating Factor; Rats; Rats, Inbred Strains; Spasm

1987
The amplifier role of platelet activating factor (PAF), other chemical mediators and antigen in the induction of airway hyperreactivity to cold.
    European journal of pharmacology, 1986, Apr-16, Volume: 123, Issue:2

    Topics: Acetylcholine; Adenosine; Animals; Antigens; Asthma, Exercise-Induced; Atropine; Bronchial Spasm; Calcium; Cold Temperature; In Vitro Techniques; Muscle Contraction; Platelet Activating Factor; Potassium Chloride; Rats; Serotonin; Trachea

1986
The responsiveness of rabbit bronchial rings to antigen, AGEPC and histamine.
    Immunopharmacology, 1986, Volume: 12, Issue:2

    Topics: Animals; Antigens; Atropine; Bronchi; Carbachol; Chlorpheniramine; Female; Histamine; Immunoglobulin E; Immunoglobulin G; Male; Muscle Contraction; Muscle, Smooth; Platelet Activating Factor; Rabbits

1986
Parasympathetic stimulation as a mechanism for platelet-activating factor-induced contractile responses in the lung.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:1

    Topics: Acetylcholine; Animals; Atropine; Cholinesterase Inhibitors; Guinea Pigs; In Vitro Techniques; Indomethacin; Lung; Muscle Contraction; Parasympatholytics; Platelet Activating Factor; Tetrodotoxin

1986
Acute effects of intratracheal administration of platelet-activating factor in baboons.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1983, Volume: 55, Issue:3

    Topics: Anesthesia, Local; Animals; Aspirin; Atropine; Bronchi; Bronchial Spasm; Lidocaine; Papio; Platelet Activating Factor; Time Factors; Trachea

1983
Methoctramine induces nonspecific airway hyperresponsiveness in vivo.
    European journal of pharmacology, 1994, Nov-14, Volume: 265, Issue:1-2

    Topics: Aerosols; Albuterol; Animals; Arachidonic Acid; Atropine; Bronchial Hyperreactivity; Bronchoconstriction; Diamines; Drug Synergism; Gallamine Triethiodide; Guinea Pigs; Histamine; Male; Muscarinic Antagonists; Ovalbumin; Parasympatholytics; Piperazines; Piperidines; Platelet Activating Factor; Propranolol; Receptors, Muscarinic

1994
Gastrointestinal physiology-regulated dogs: utilization of a bioavailability study of a new thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]-diazepine, an antagonist of platelet-activating factor, and its preparations.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:1

    Topics: Administration, Oral; Animals; Atropine; Azepines; Biological Availability; Chromatography, High Pressure Liquid; Dogs; Dosage Forms; Humans; Injections, Intravenous; Intestinal Absorption; Male; Pentagastrin; Platelet Activating Factor; Solubility; Tablets; Triazoles

1994
Modulation by drugs acting on the autonomic nervous system of platelet-activating factor in the stomach of rats.
    Biochemical pharmacology, 1993, Jul-06, Volume: 46, Issue:1

    Topics: Animals; Atropine; Autonomic Agents; Carbachol; Catecholamines; Dopamine; Gastric Mucosa; Male; Oxidopamine; Platelet Activating Factor; Rats; Rats, Wistar; Stress, Physiological

1993
Airway hyperresponsiveness in transgenic mice overexpressing platelet activating factor receptor is mediated by an atropine-sensitive pathway.
    American journal of respiratory and critical care medicine, 2002, Jan-15, Volume: 165, Issue:2

    Topics: Animals; Atropine; Bronchial Diseases; Bronchoconstrictor Agents; Bronchodilator Agents; Disease Models, Animal; Free Radical Scavengers; Methacholine Chloride; Mice; Mice, Transgenic; Muscle, Smooth; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Muscarinic; Respiratory System; Serotonin; Signal Transduction

2002