1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with arachidonic acid in 523 studies
| Studies (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Trials (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Recent Studies (post-2010) (1-hexadecyl-2-acetyl-glycero-3-phosphocholine) | Studies (arachidonic acid) | Trials (arachidonic acid) | Recent Studies (post-2010) (arachidonic acid) |
|---|---|---|---|---|---|
| 9,156 | 187 | 552 | 19,295 | 486 | 3,040 |
| Protein | Taxonomy | 1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50) | arachidonic acid (IC50) |
|---|---|---|---|
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | 4.5 | |
| Fatty acid-binding protein, adipocyte | Homo sapiens (human) | 2.75 | |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | 4.5 | |
| 60 kDa chaperonin | Escherichia coli | 7.3 | |
| 10 kDa chaperonin | Escherichia coli | 7.3 | |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | 1.0715 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 0.6026 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 207 (39.58) | 18.7374 |
| 1990's | 253 (48.37) | 18.2507 |
| 2000's | 47 (8.99) | 29.6817 |
| 2010's | 13 (2.49) | 24.3611 |
| 2020's | 3 (0.57) | 2.80 |
| Authors | Studies |
|---|---|
| Colwell, JA; Halushka, PV; Nair, RM; Rogers, C; Sagel, J; Whetsell, A | 1 |
| Huang, TG; Ju, DW; Rui, YC; Sun, DX; Zeng, GQ; Zhu, J | 1 |
| Aepfelbacher, M; Lux, I; Weber, PC; Ziegler-Heitbrock, HW | 1 |
| Baroni, A; Biancone, L; Camussi, G; Giovane, A; Iorio, EL; Tetta, C; Tufano, MA | 1 |
| Bito, H; Honda, Z; Izumi, T; Nakamura, M; Shimizu, T | 1 |
| Müller, S; Nigam, S | 1 |
| Dunn, MJ; Kester, M; Thomas, CP; Wang, J | 1 |
| Schatz-Munding, M; Ullrich, V | 1 |
| Bass, DA; Bauldry, SA; Elsey, KL | 1 |
| Bachelet, M; Barre, A; Chouaid, C; Havet, N; Housset, B; Masliah, J; Vargaftig, BB | 1 |
| Babycos, CR; Hood, JS; Ibrahim, IN; Kadowitz, PJ; McMahon, TJ; Nossaman, BD; Ragheb, MS | 1 |
| Babycos, CR; Hood, JS; Ibrahim, IN; Kadowitz, PJ; McMahon, TJ; Nossaman, BD | 1 |
| Friedman, M; Koren, HS; Madden, MC; Samet, JM | 1 |
| Lefort, J; Perrisoud, D; Pretolani, M; Vargaftig, BB; Venco, C | 1 |
| Lee, TC; Snyder, F; Uemura, Y | 1 |
| Alves, AC; Cordeiro, RS; Diaz, BL; e Silva, PM; Lima, MC; Martins, MA | 1 |
| Kunievsky, B; Yavin, E | 1 |
| Ko, FN; Lin, CN; Liou, SS; Teng, CM | 1 |
| Chilton, FH; Hubbard, WC; Sung, CM; Winkler, JD | 2 |
| Christman, BW; Hwang, YS; King, GA; Lefferts, PL; Snapper, JR; Trochtenberg, DS | 1 |
| Hibler, S; Ibe, BO; Raj, JU; Toga, H | 1 |
| Tatarintsev, AV; Varfolomeyev, SD; Vrzheshch, PV; Yershov, DE | 1 |
| Huang, SC; Huang, TF; Li, HL; Teng, CM; Wu, TS | 1 |
| Chilton, FH; Fonteh, AN; Triggiani, M | 1 |
| Fujii, T; Hashizume, T; Sato, T | 1 |
| Misso, NL; Stewart, GA; Taylor, ML; Thompson, PJ | 2 |
| Holgate, ST; Lai, CK | 1 |
| Breton, M; Colard, O; Joly, F; Ninio, E; Wolf, C | 1 |
| Manning, PJ; O'Byrne, PM | 1 |
| Chepenik, KP; Wykle, RL | 1 |
| Bin, Z; Kun, L | 1 |
| Galli, C; Marangoni, F; Petroni, A | 1 |
| Blank, ML; Lee, TC; Snyder, F | 1 |
| Dohi, T; Kitayama, S; Morita, K; Tsujimoto, A | 1 |
| Levine, L | 2 |
| Beilin, LJ; Croft, KD; Moulton, C; Proudfoot, J | 1 |
| Borgeat, P; Palmantier, R | 2 |
| Elsasser, S; Perruchoud, AP | 1 |
| Balsinde, J; Fernández, B | 1 |
| Elmore, M; Kellie, S; Murphy, CT; Westwick, J | 1 |
| Harris, T; Stewart, AG | 1 |
| Ammit, AJ; O'Neill, C | 1 |
| Teng, CM; Wang, JP | 1 |
| Tattersfield, AE | 1 |
| Fernandez-Gallardo, S; Garcia, C; Garcia, MC; Gijon, MA; Nieto, ML; Sanchez Crespo, M | 1 |
| Forn, J; García-Rafanell, J; Gómez, LA; Merlos, M; Vericat, L | 1 |
| Furman, BL; Gray, GA; Parratt, JR | 1 |
| Bosia, A; Bussolino, F; Garbarino, G; Ghigo, D; Heller, R; Pescarmona, G; Schröder, H; Till, U | 1 |
| Abraham, WM; Ahmed, A; Cortes, A; Garcia, L; Lansing, MW; Lauredo, IT; Mansour, E; Wanner, A | 1 |
| Deguchi, K; Murashima, S | 1 |
| Ishii, Y; Kitamura, S; Kobayashi, J | 1 |
| Leong, L; Sturm, M; Taylor, R | 1 |
| Blasevich, M; Caruso, D; Galli, C; Petroni, A; Visioli, F; Zancocchia, B | 1 |
| Salari, H; Schellenberg, RR | 1 |
| Blasevich, M; Galli, C; Petroni, A; Visioli, F | 1 |
| Borgeat, P; Braquet, M; Braquet, P; Krump, E; McColl, SR; Naccache, PH; Poubelle, PE | 1 |
| Bass, DA; Bauldry, SA; Cousart, SL; McCall, CE | 1 |
| Ahnfelt-Rønne, I; Kirstein, D; Larsen, CG; Skak-Nielsen, T; Thestrup-Pedersen, K; Thomsen, HK; Thomsen, MK | 1 |
| Franklin-Johnson, J; Kuruvilla, A; Mangus, L; Putcha, G; Schulam, PG; Shearer, WT | 1 |
| Asmis, R; Dennis, EA; Glaser, KB | 1 |
| Waku, K | 1 |
| Capecchi, PL; Ceccatelli, L; Di Perri, T; Gistri, A; Laghi Pasini, F; Mazza, S; Pasqui, AL | 1 |
| Arita, H | 1 |
| Nakagawa, Y | 1 |
| Takahashi, O | 1 |
| Buckalew, VM; Handa, RK; Strandhoy, JW | 1 |
| Ahmed, Y; Elder, MG; Sullivan, MH | 1 |
| Saeed, SA | 1 |
| Clay, KL; Johnson, C; Worthen, GS | 1 |
| Dyson, MC; Kadowitz, PJ | 1 |
| Glusa, E | 1 |
| Hatakeyama, K; Watanabe, K; Yano, S | 1 |
| Bishai, I; Coceani, F; Hynes, N; Lees, J | 1 |
| Kinjoh, K; Kosugi, T; Nakamura, M; Saitoh, S | 1 |
| Naps, MS; Rubin, RP; Thompson, RH | 1 |
| Croset, M; Fonlupt, P; Lagarde, M | 1 |
| Di Marzo, V; Galadari, SH; Morris, HR | 1 |
| Borgeat, P; Braquet, M; Krump, E; McColl, SR; McDonald, PP; Naccache, PH | 1 |
| Gilani, AH; Husnain, SQ; Saeed, SA; Suria, A | 1 |
| Dujovne, CA; Harris, WS; Silveira, S | 1 |
| Kambayashi, J; Kawasaki, T; Mori, T; Sakon, M; Shiba, E; Uemura, Y | 1 |
| Blank, ML; Kawasaki, T; Snyder, F; Suga, K | 1 |
| Inada, Y; Kojima, S; Saito, Y; Sato, F; Sekiya, F; Tsukada, T | 1 |
| Gilani, AH; Saeed, SA | 1 |
| Chilton, FH; Connell, TR; Triggiani, M | 1 |
| Béréziat, G; Cherqui, G; Etienne, J; Kadiri, C; Masliah, J; Rybkine, T | 1 |
| Akedo, Y; Kaku, S; Nagakawa, Y; Orimo, H | 1 |
| Bazan, HE; Bazan, NG; de Abreu, MT | 1 |
| Fukuda, T; Masuzawa, Y; Sugiura, T; Waku, K | 1 |
| Basha, MA; Kasahara, K; Kunkel, SL; Lynch, JP; Standiford, TJ; Strieter, RM | 1 |
| Christophers, E; Morita, E; Schröder, JM | 2 |
| Chavis, C; Crastes de Paulet, A; Damon, M; Godard, PH; Michel, FB; Radeau, T | 1 |
| Lim, WH; Stewart, AG | 1 |
| McIntyre, TM; Prescott, SM; Whatley, RE; Zimmerman, GA | 1 |
| Randriamampita, C; Trautmann, A | 1 |
| Hauser, A; Heinroth-Hoffmann, I; Mest, HJ | 1 |
| Huang, TF; Ko, FN; Liu, YM; Sheu, SJ; Teng, CM | 1 |
| Hecker, G; Ney, P; Schrör, K | 1 |
| Borgeat, P; Laviolette, M; Ménard, L; Naccache, PH; Pilote, S | 1 |
| Grinstein, S; Lu, DJ | 1 |
| Austen, KF; Benincaso, AI; Coblyn, JS; Larkin, JK; Sperling, RI; Weinblatt, ME | 1 |
| Haranaka, K; Haranaka, R; Iimura, F; Sakurai, A; Satomi, N | 1 |
| Chao, W; Hanahan, DJ; Liu, H; Olson, MS | 1 |
| Beilin, LJ; Croft, KD; Masarei, J; Rouse, I; Vandongen, R | 1 |
| Careaga-Houck, M; Sprecher, H | 1 |
| Fox, CC; Kagey-Sobotka, A; Lichtenstein, LM; MacGlashan, DW; Peters, SP; Schleimer, RP | 1 |
| Morris, HG | 1 |
| Benveniste, J; Chignard, M; Coëffier, E | 1 |
| Prunieras, M | 1 |
| Blache, D; Ciavatti, M | 1 |
| Melder, DC; Olsen, RA; Powis, G; Schlager, JJ; Seewald, MJ | 1 |
| Lefer, AM | 1 |
| Molski, TF; Sha'afi, RI; Tao, W | 1 |
| Ewenstein, BM; Pober, JS; Schafer, AI; Zavoico, GB | 1 |
| Lianos, EA | 1 |
| Hanahan, DJ; Kumar, R; Nunez, D | 1 |
| Bompiani, GD; Cardella, F; Davì, G; Giardina, E; Meli, F; Strano, A; Triolo, G | 1 |
| Briand, H; Burka, JF; Pasutto, FM; Scott-Savage, P | 1 |
| Houben, A; Lenoir, G; Remacle, J; Remy, E; Vandesteene, C | 1 |
| Pacitti, N; Parratt, JR; Rodger, IW | 1 |
| Jandrot-Perrus, M; Touqui, L; Vargaftig, BB | 1 |
| Ershov, DE; Fedorov, NA; Tatarintsev, AV; Varfolomeev, SD; Vrzheshch, PV; Zaĭtsev, SV | 1 |
| Murphy, S; Welk, G | 1 |
| Benveniste, J; Bouloux, C; Chignard, M; Delautier, D; Lalau Keraly, C; Motte, G; Sebag, C | 1 |
| Bryant, NL; Guccione, MA; Kinlough-Rathbone, RL; Mustard, JF; Packham, MA | 1 |
| Hampel, G; Jaffe, EA; Watanabe, K; Weksler, BB | 1 |
| Benveniste, J; Dulioust, A; Haye-Legrand, I; Meslier, N; Roubin, R; Vivier, E | 1 |
| Cassaro, CM; Chamone, DA; Maeda, NY; Sampaio, CA; Sampaio, MU | 1 |
| Ludwig, H | 1 |
| Braquet, P; Hosford, D; Mencia-Huerta, JM; Sturk, A; ten Cate, JW | 1 |
| Bielawiec, M; Bodzenta-Lukaszyk, A; Gabryelewicz, A; Lukaszyk, A | 1 |
| Franson, RC; Rosenthal, MD; Vishwanath, BS | 1 |
| O'Flaherty, JT; Tessner, TG; Wykle, RL | 1 |
| Hsueh, W; Needleman, P; Spaethe, SM | 1 |
| Benigni, A; Bertani, T; Livio, M; Macconi, D; Morigi, M; Orisio, S; Patrono, C; Perico, N; Remuzzi, G; Ubiali, A | 1 |
| Heidel, JR; Laegreid, WW; Leid, RW; Liggitt, HD; Silflow, RM; Taylor, SM | 1 |
| Nakashima, S; Nozawa, Y; Sato, M; Suganuma, A; Tohmatsu, T | 1 |
| Feuerstein, G; Sirén, AL | 1 |
| Bernardini, R; Brucke, T; Calogero, AE; Chrousos, GP; Ehrlich, YH; Gold, PW | 1 |
| Tai, HH; Tanizawa, H | 1 |
| Borgeat, P; Caon, AC; McColl, SR; Naccache, PH | 1 |
| Burch, RM; Tiffany, CW | 1 |
| Bauer, JA; Conzen, P; Fritz, H; Wurster, K | 1 |
| Phillips, WA; Stewart, AG | 1 |
| Audette, CA; Burstein, SH; Doyle, SA; Hull, K; Hunter, SA; Latham, V | 1 |
| Franson, RC; Rosenthal, MD | 1 |
| Alonso, MT; Garcia-Sancho, J; Sanchez, A | 1 |
| Gentry, PA; Liptrap, RM; Niemuller, C; Ross, ML | 1 |
| Beetens, JR; De Clerck, F; Folkerts, G; Nijkamp, FP | 1 |
| Marone, G | 1 |
| Blair, IA; Cragoe, EJ; Frazer, M; Limbird, LE; Reed, PW; Schwartzberg, MS; Sweatt, JD | 1 |
| Hanahan, DJ; Olson, MS; Saito, K; Steinhelper, ME; Sugatani, J | 1 |
| Austen, KF; Kylander, KA; Lee, TH; Lewis, RA; Robin, JL; Sperling, RI | 1 |
| Benveniste, J; Bourdillat, B; Brink, C; Delautier, D; Labat, C; Potier, P | 1 |
| Kraemer, R; Mullane, KM; Westlin, W | 1 |
| Behrens, T; Goodwin, JS | 1 |
| Abraham, WM | 1 |
| Grinstein, S; Nasmith, PE | 1 |
| Adolfs, MJ; Bachelet, M; Bereziat, G; Bonta, IL; Masliah, J; Vargaftig, BB | 1 |
| Camp, RD; Greaves, MW | 1 |
| Cano, E; Fernandez-Gallardo, S; Garcia, MC; Gijon, MA; Sanchez Crespo, M | 1 |
| Barden, A; Beilin, LJ; Codde, JP; Croft, KD; Vandongen, R | 1 |
| Houston, DS; Miller, VM; Rubanyi, GM; Vanhoutte, PM | 1 |
| Criscuoli, M; Subissi, A | 1 |
| Benveniste, J; Hirafuji, M; Mencia-Huerta, JM | 1 |
| Asyee, GM; Schaap, MC; Sturk, A; ten Cate, JW; van Maanen, M | 1 |
| Blank, M; Lee, TC; Malone, B; Robinson, M; Snyder, F; Woodard, D | 1 |
| Ambler, J; Birch, J; Maguire, ED; Wallis, RB | 1 |
| Kumahara, Y; Masugi, F; Oda, M; Ogihara, T; Saeki, S; Saito, K; Sakaguchi, K; Satouchi, K; Tokunaga, K | 1 |
| Bachelet, M; Errasfa, M; Russo-Marie, F | 1 |
| Loeb, AL; Peach, MJ; Singer, HA | 1 |
| Borgeat, P; Braquet, M; Braquet, P; Chignard, M; Dormont, D; Ducousso, R; Garay, R; Guilbaud, J; Lavaud, P | 1 |
| Meyers, KM | 1 |
| Dangelmaier, C; Mauco, G; Purdon, AD; Smith, JB | 1 |
| Pickett, WC; Ramesha, CS | 4 |
| Arese, P; Biffignandi, P; Bussolino, F | 1 |
| Beneker, C; De Boer, E; Harmsen, HJ; Raaijmakers, JA; Van Rozen, RJ | 1 |
| Del Maschio, A; Iliou, JP; Maclouf, J | 1 |
| Chavis, C; Crastes De Paulet, A; Damon, M; Godard, P; Michel, FB | 1 |
| Nishihira, J; O'Flaherty, JT | 1 |
| Henderson, WR | 1 |
| Piper, PJ; Stewart, AG | 4 |
| Parker, CW | 1 |
| Kawaguchi, H; Yasuda, H | 3 |
| Fuse, I; Hanano, M; Hattori, A; Higashihara, M; Koike, T; Nagayama, R; Shibata, A; Takahashi, H; Takeshige, T; Takizawa, S | 1 |
| Ando, T; Aoki, H; Iwami, M; Kohsaka, M; Nishikawa, M; Okamoto, M; Yoshida, K | 1 |
| Valone, FH | 1 |
| Adkinson, NF; Davidson, DA; Lichtenstein, LM; Schleimer, RP | 1 |
| Benveniste, J; Braquet, P; Chignard, M; Korth, R; Le Couedic, JP; Norel, X; Nunez, D; Spinnewyn, B | 1 |
| Lewis, RA | 1 |
| Metz, SA | 1 |
| Daniel, LW; Waite, M; Wykle, RL | 1 |
| Finiasz, M; Gimeno, M; Lazzari, MA; Schattner, MA | 1 |
| Neuwirth, R; Schlondorff, D | 1 |
| Akkerman, JW; Gorter, G; Hasselaar, P; Kloprogge, E | 1 |
| Bachelet, M; Bereziat, G; Colard, O; Masliah, J; Vargaftig, BB | 1 |
| Alonso, F; Henson, PM; Leslie, CC | 1 |
| Borgeat, P; Braquet, P; Harczy, M; Maclouf, J; Pradelles, P; Sirois, P | 1 |
| Blank, ML; Johnson, D; Lee, TC; Malone, B; Robinson, M; Snyder, F; Woodard, DS | 1 |
| Wallace, JL; Whittle, BJ | 1 |
| Frölich, JC; Küster, LJ | 1 |
| Detty, DM; Leslie, CC | 1 |
| Berti, F; Braquet, P; Omini, C; Rossoni, G | 1 |
| Aurousseau, M; Benveniste, J; Chignard, M; Greiss, M; Lalau Keraly, C; Maamer, M | 1 |
| Akkerman, JW; Kloprogge, E | 1 |
| Joseph, S; Kakkar, VV; Krishnamurthi, S | 1 |
| D'Humières, S; Russo-Marie, F; Vargaftig, BB | 1 |
| Criscuoli, M; Daffonchio, L; Omini, C; Subissi, A | 1 |
| Esterbauer, H; Hurst, JS; Juergens, G; Lang, J; Slater, TF; Zollner, H | 1 |
| Cerutti, P; Emerit, I; Jörg, A; Kozumbo, WJ; Muehlematter, D | 1 |
| Hanahan, DJ; Miwa, M; Sugatani, J | 1 |
| Burka, JF | 1 |
| Haroldsen, PE; Henson, JE; Henson, PM; Murphy, RC; Voelkel, NF | 1 |
| Mathias, M; Morganroth, ML; Pickett, WC; Reeves, JT; Voelkel, NF; Worthen, S | 1 |
| Bienenstock, J; Denburg, J; Dolovich, J; Ernst, P; Gauldie, J; Jordana, M; Stead, R; Tomioka, M | 1 |
| Chen, WY; Ko, WC; Ouyang, CH; Teng, CM | 1 |
| Tou, JS | 1 |
| Bell, RM; Greenberg, CS; Hannun, YA | 1 |
| Csonka-Khalifah, L; Maguire, MH | 1 |
| Smith, TF | 1 |
| Bruijnzeel, PL; Hamelink, ML; Kijne, AM; Kok, PT; Verhagen, J | 1 |
| Coëffier, E; Joseph, D; Prévost, MC; Vargaftig, BB | 1 |
| Hayashi, Y; Hirasawa, N; Ohuchi, K; Sugidachi, A; Tsurufuji, S; Watanabe, M | 1 |
| Braquet, P; Neuwirth, R; Satriano, JA; Schlondorff, D; Singhal, P | 1 |
| Calhoun, W; Carlson, RP; Chang, J | 1 |
| Hirafuji, M; Nave, JF | 1 |
| Vandongen, R | 1 |
| Picado, C; Plaza, V | 1 |
| Altin, JG; Bygrave, FL | 1 |
| Iwahashi, K; Kase, H; Yamada, K | 1 |
| Myers, AK; Nakanishi, T; Ramwell, P | 1 |
| Bruynzeel, PL; Hamelink, ML; Kijne, AM; Koenderman, L; Kok, PT; Verhagen, J | 1 |
| Azami, K; Hasegawa, T; Hoshi, M; Ohura, T; Ono, I; Tsutsumi, M | 1 |
| Altman, R; Funes, JC; Scazziota, A | 1 |
| Bazan, HE; Bazan, NG; Braquet, P; Reddy, ST | 1 |
| Schilling, W; Slapke, J | 1 |
| Fraser Mustard, J; Kinlough-Rathbone, RL; Packham, MA; Rand, ML | 1 |
| Channon, JY; Leslie, CC; Voelker, DR; Wall, MM; Zelarney, PT | 1 |
| Bimmler, M; Donath, E; Egger, M; Glaser, R; Spangenberg, P; Till, U | 1 |
| De Rijke, YB; Kuiper, J; Van Berkel, TJ; Van Waas, MP; Zijlstra, FJ | 1 |
| Blauhut, B; Doran, JE; Lundsgaard-Hansen, P | 1 |
| Brown, ME; Jones, JE; Rosenthal, MD | 1 |
| Csatò, M; Czarnetzki, BM; Rosenbach, T | 1 |
| Miadonna, A; Tedeschi, A | 1 |
| Cassina, G; Livio, M; Macconi, D; Morelli, C; Morzenti, G; Remuzzi, G | 1 |
| FitzGerald, GA; Pedersen, AK | 1 |
| Lee, T; Malone, B; Snyder, F | 1 |
| Vigo, C | 1 |
| Sugiura, T; Waku, K | 1 |
| Khan, SN; Lane, PA; Smith, AD | 1 |
| Tou, J | 1 |
| Billah, MM; Bryant, RW; Siegel, MI | 1 |
| Benveniste, J; Billerey, M; Buonocore, M; Chignard, M; Driss, F; Juhan-Vague, I; Poisson, C; Roul, C; Vague, P | 1 |
| Ma, YH; Ouyang, CH; Teng, CM | 1 |
| Abdel-Latif, AA; Yousufzai, SY | 1 |
| Benveniste, J; Chignard, M | 1 |
| Brooks, DP; Chesney, CM; Crofton, JT; Huch, KM; Pifer, DD; Share, L | 1 |
| Altman, R; Rouvier, J; Weisenberger, H | 1 |
| Ip, M; Kwan, S; Lam, WK; So, SY | 1 |
| Moore, TL; Weiss, TD | 1 |
| Landolfi, R; Motola, NC; Steiner, M; Turcotte, JG | 1 |
| Giles, TD; Given, MB; Sander, GE | 1 |
| Chap, H; Douste-Blazy, L | 1 |
| Metcalfe, DD | 1 |
| Gerrard, JM | 1 |
| Bach, MK | 1 |
| Ehrlich, YH; Kornecki, E; Lenox, RH | 1 |
| Wasserman, SI | 2 |
| Adams, GK; Adkinson, NF; Kagey-Sobotka, A; Lichtenstein, LM; MacGlashan, DW; Peters, SP; Schleimer, RP; Schulman, ES | 1 |
| Lees, CJ; McCall, CE; O'Flaherty, JT; Shewmake, T; Thomas, MJ; Wykle, RL | 1 |
| Gorman, RR; Hopkins, NK; Lin, AH | 1 |
| Kalter, ES | 1 |
| Inada, Y; Nishikawa, K; Nomura, H; Terashita, Z; Tsushima, S; Yoshioka, Y | 1 |
| Lee, TC; Malone, B; Snyder, F | 1 |
| Billah, MM; Johnston, JM | 1 |
| Chilton, FH; Ellis, JM; O'Flaherty, JT; Swendsen, CL; Wykle, RL | 2 |
| MacIntyre, DE; Pollock, WK | 1 |
| Bult, H; Herman, AG | 1 |
| Kay, AB | 1 |
| Mueller, HW; Purdon, AD; Smith, JB; Wykle, RL | 1 |
| Baud, L; Hagege, J; Perez, J; Satriano, JA; Schlondorff, D | 1 |
| Greene, DG; Mueller, HW; O'Flaherty, JT; Samuel, MP; Wykle, RL | 1 |
| White, GC | 1 |
| Lapetina, EG; Siess, W; Weber, PC | 1 |
| Guccione, MA; Kinlough-Rathbone, RL; Mustard, JF; Nina, M; Packham, MA | 1 |
| Lefort, J; Rotilio, D; Vargaftig, BB | 1 |
| Bergstrand, H; Dahlbäck, M; Sörenby, L | 1 |
| Dangelmaier, C; Hassell, B; Holmsen, H; Rao, AK; Smith, JB; Willis, J | 1 |
| Chilton, FH; Ellis, JM; Olson, SC; Wykle, RL | 1 |
| Huston, L; Leid, RW; Liggitt, HD | 1 |
| Albert, DH; Snyder, F | 1 |
| Deykin, D; Kramer, RM; Patton, GM; Pritzker, CR | 1 |
| Benveniste, J; Chignard, M; Coëffier, E; Le Couedic, JP | 1 |
| Block, HU; Ostermann, G; Till, U | 1 |
| Chilton, FH; DeChatelet, LR; O'Flaherty, JT; Thomas, MJ; Waite, BM; Walsh, CE; Wykle, RL | 1 |
| Henson, PM | 1 |
| Arnoux, B; Benveniste, J; Durand, J; Rigaud, M; Vargaftig, BB | 1 |
| Chignard, M; Lefort, J; Vargaftig, BB; Wal, F | 1 |
| Burrell, R; Gee, JB; Morgan, WK; Vesterlund, J; Willoughby, WF | 1 |
| Rao, GH; White, JG | 1 |
| Bussolino, F; Locati, M; Mantovani, A; Proost, P; Rieppi, M; Sozzani, S; Van Damme, J; Zhou, D | 1 |
| Cotterill, T; Harris, T; Stewart, AG | 1 |
| Maclouf, J; Pretolani, M; Vargaftig, BB; Zuany-Amorim, C | 1 |
| Antunes, E; Cirino, G; de Nucci, G; Donato, JL; Faro, R; Hyslop, S; Landucci, EC; Marangoni, S; Oliveira, B | 1 |
| Conroy, MC; Finkel, M; Grabow, D; Lesch, M; Low, J; Metz, A; Schrier, D; Sommers, C; Wallace, J | 1 |
| Adams, JL; Badger, A; Bolognese, B; Chabot-Fletcher, M; Flamberg, PL; Hall, RH; Marshall, LA; Roshak, A; Sung, CM; Winkler, JD | 1 |
| Akiba, S; Fujii, T; Hashizume, T; Naka, M; Sato, T; Sugatani, J | 1 |
| Borgeat, P; Krump, E; Naccache, PH; Pouliot, M | 1 |
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| Aepfelbacher, M; Haag, H; Weber, C; Weber, PC; Ziegler-Heitbrock, HW | 1 |
| Nigam, S; Svetlov, S | 1 |
| Hirafuji, M; Shinoda, H | 1 |
| Chung, D; Gravel, S; Powell, WS | 1 |
| Logun, C; Rieves, RD; Shelhamer, JH; Wu, T | 1 |
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| Chen, XS; Funk, CD; Griffis, G; Kurre, U | 1 |
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| Aragonés, MD; Catalán, RE; Garde, E; Lombardía, M; Martínez, AM; Ortega, P | 1 |
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| Ko, FN; Lin, CN; Shieh, WL; Teng, CM | 1 |
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| Boll, RM; Gustafson-Svärd, C; Kald, B; Tagesson, C | 1 |
| Baldi, E; Carloni, V; Casano, R; Falsetti, C; Forti, G; Gervasi, G; Krausz, C | 1 |
| Bazan, HE; Hurst, JS | 2 |
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| Ko, FN; Lai, SC; Lin, CN; Lin, HC; Liou, SS; Liu, HW; Teng, CM | 1 |
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| Aihara, M; Bito, H; Kume, K; Mori, M; Sakanaka, C; Shimizu, T; Tabuchi, S | 1 |
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| Ito, S; Komiyama, Y; Miwa, M; Sugatani, J | 1 |
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| Bisogno, L; Cifone, MG; Frati, L; Gismondi, A; Milella, M; Palmieri, G; Roncaioli, P; Santoni, A | 1 |
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| Chang, YL; Hsueh, CM; Ko, FN; Lee, SS; Liu, KC; Teng, CM | 1 |
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| Aihara, M; Ishii, S; Kume, K; Mishina, M; Shimizu, T; Tabuchi, S | 1 |
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| Gilani, AH; Nawaz, Z; Saeed, SA; Shah, BH; Shamim, G | 1 |
| Meyer, T; Oancea, E; Quest, AF; Teruel, MN | 1 |
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| Berón de Astrada, M; Chaud, MA; Franchi, AM; Gimeno, MF | 1 |
| Ishii, I; Izumi, T; Saito, E; Shimizu, T; Ui, M | 1 |
| Borgeat, P; Boudreault, S; Krump, E; Surette, ME | 1 |
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| Barber, LA; Dy, LC; Fertel, RH; Johnson, CA; Kelley, SW; Murphy, RC; Nguyen, TM; Pei, Y; Travers, JB; Williams, DA | 1 |
| Chen, IS; Ishikawa, T; Teng, CM; Tsai, IL; Wun, MF | 1 |
| Ali, IQ; Gilani, AH; Nawaz, Z; Saeed, SA; Shah, BH; Virani, SS | 1 |
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| Aida, Y; Fukaya, H; Kasama, T; Sugiyama, K; Takeuchi, N; Tobinaga, S | 1 |
| Hanahan, DJ; Javors, MA; Siafaka-Kapadai, A; Svetlov, S | 1 |
| Hajjar, JJ; Molski, TF; Nagarkatti, D; Sha'afi, RI; Syrbu, SI; Waterman, WH | 1 |
| Balestrieri, C; Balestrieri, ML; Lee, TC; Malik, KU | 1 |
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| Gilani, AH; Mahmood, H; Nawaz, Z; Pertani, SA; Roomi, A; Saeed, SA; Shah, BH | 1 |
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| Burgermeister, E; Heinrich, PC; Küster, A; Pessara, U; Scheuer, WV; Tibes, U | 1 |
| Hichami, A; Legrand, AB; Martin-Chouly, CA; Menier, V; Noel, F; Pedrono, F; Youmine, H | 1 |
| Ko, FN; Liao, CH; Teng, CM; Wu, CL | 1 |
| Balboa, MA; Balsinde, J; Dennis, EA; Li, WH; Llopis, J | 1 |
| Bock, CB; Haribabu, B; Sellars, DD; Snyderman, R; Steeber, DA; Verghese, MW | 1 |
| Baldi, E; Bonaccorsi, L; Cioppi, F; Forti, G; Granchi, S; Luconi, M; Maggi, M; Miele, L; Mini, E; Muratori, M; Peri, A; Pesciullesi, A; Serio, M | 1 |
| Enomoto, A; Gelb, MH; Ghomashchi, F; Koduri, RS; Kudo, I; Lambeau, G; Murakami, M; Seki, M; Shimbara, S; Singer, A; Valentin, E; Yoshihara, K | 1 |
| Hour, MJ; Huang, LJ; Ko, TC; Kuo, SC; Lee, KH; Lien, JC; Teng, CM | 1 |
| Ibe, BO; Raj, JU | 1 |
| Kohno, S; Nabe, T | 1 |
| Lee, RK; Teather, LA; Wurtman, RJ | 1 |
| Fonteh, AN | 1 |
| Chen, ZH; Hao, XJ; Li, L; Shen, YM; Shen, ZQ; Yang, XS; Zuo, GY | 1 |
| Grandel, U; Grimminger, F; Hattar, K; Hoffmann, S; Mayer, K; Schenkel, A; Seeger, W; Sibelius, U | 1 |
| Huang, XL; Lawrence, M; Madara, P; Nanavaty, UB; Pawliczak, R; Shelhamer, JH | 1 |
| Chang, FR; Du, YC; Kuo, RY; Patnam, R; Wang, WY; Wu, CC; Wu, YC | 1 |
| Chen, Z; Cheng, P; Dong, Z; Li, L; Liu, J; Shen, Z | 1 |
| Beck-Speier, I; Dayal, N; Denzlinger, C; Haberl, C; Heyder, J; Maier, KL; Ziesenis, A | 1 |
| Bosco, O; Camussi, G; Del Sorbo, L; Emanuelli, G; Fascio Pecetto, P; Goffi, A; Lupia, E; Montrucchio, G; Omedè, P | 1 |
| Jung, TT; Park, SK; Rhee, CK | 1 |
| Croxtall, JD; Gilroy, DW; Newson, J; Sawmynaden, P; Willoughby, DA | 1 |
| Biasi, F; Chiarpotto, E; Leonarduzzi, G; Poli, G | 1 |
| Chen, CL; Chou, JD; Chou, KJ; Chung, HM; Fang, HC; Hwang, YY; Jan, CR; Lee, PT | 1 |
| Brown, GE; Cherepanov, V; Degousee, N; Downey, GP; Gelb, MH; Ghomashchi, F; Glogauer, M; Grinstein, S; Harkin, DW; Kelvin, D; Koh, A; Lindsay, TF; Nallan, L; Plumb, J; Rubin, BB; Sadilek, M; Smart, BP; Stefanski, E; Sun, C; Vachon, E; Yaffe, MB | 1 |
| Hsieh, HK; Ko, HH; Lin, CN; Lin, HC; Liu, CT; Teng, CM | 1 |
| Chang, HT; Chen, JS; Cheng, HH; Ho, CM; Hsu, SS; Huang, CJ; Huang, JK; Jan, CR; Jiann, BP; Lo, YK; Yeh, JH | 1 |
| Creer, MH; Kell, PJ; McHowat, J; Meyer, MC | 1 |
| Creer, MH; McHowat, J; Meyer, MC | 1 |
| Besana, A; Feinmark, SJ; Robinson, RB | 1 |
| Chang, GT; Chang, YC; Chung, KH; Kang, SK; Kim, CH; Kim, JH | 1 |
| Antonopoulou, S; Demopoulos, CA; Fragopoulou, E; Karantonis, HC; Phenekos, C; Rementzis, J | 1 |
| Buchanan, MR | 1 |
| Chen, CC; Hsu, HC; Huang, HY; Tsai, WJ; Tsai, YC; Yang, WC | 1 |
| Slomiany, A; Slomiany, BL | 3 |
| Antonopoulou, S; Fragopoulou, E; Ginis, A; Karantonis, HC; Mitsou, E; Mourelatos, A; Phenekos, C; Rementzis, J; Sitara, M | 1 |
| Imai, H; Kitahara, J; Nakagawa, Y; Sakamoto, H; Tosaki, T | 1 |
| Chang, FR; Chen, KS; Chia, YC; Chiang, MY; Lan, YH; Wang, JC; Wu, CC; Wu, YC | 1 |
| Gao, L; Lu, FR; Pan, LM; Qin, Y; Shen, L; Shi, W | 1 |
| Dong, Q; Kurek, C; Patel, MI | 1 |
| Caplan, MS; Jilling, T; Li, D; Lu, J | 1 |
| Chang, HW; Peng, S; Wang, W; Wang, Y; Zhang, X; Zhao, M; Zheng, M | 1 |
| McHowat, J; Rastogi, P | 1 |
| Gelb, MH; Giannattasio, G; Granata, F; Lai, Y; Lambeau, G; Leslie, CC; Marone, G; Mounier, CM; Nallan, L; Oslund, R; Triggiani, M | 1 |
| Azambuja, P; Castro, DP; Figueiredo, MB; Garcia, ES; Genta, FA; Ribeiro, IM; Tomassini, TC | 1 |
| Bazan, HE; Kenchegowda, S | 1 |
| Berge, RK; Felberg, HS; Johansen, B; Jørgensen, KM; Laegreid, A | 1 |
| Coy Barrera, ED; Cuca Suárez, LE | 1 |
| McHowat, J; Sharma, J; Turk, J | 1 |
| Faxvaag, A; Feuerherm, AJ; Johansen, B; Leistad, L | 1 |
| Ahmad, S; Ahmed, S; Hanif, M; Qayum, M; Rizwani, GH; Zia-Ul-Haq, M | 1 |
| Lambeau, G; Murakami, M | 1 |
| Kang, JW; Lee, JH; Min, BS | 1 |
| De Nucci, G; Donato, JL; Lilla, S; Lorenzetti, R; Maziero, AM | 1 |
| Feng, Q; Jiang, X; Liu, J; Ma, H; Peng, S; Tang, J; Wang, Y; Wu, J; Xu, W; Zhao, M; Zhu, H | 1 |
| Huang, GJ; Kuo, PC; Lee, KH; Liao, YR; Tsai, WJ; Wu, TS | 1 |
| Antonopoulou, S; Laios, K; Moschos, MM; Moustafa, GA; Papakonstantinou, VD; Tsatsos, M | 1 |
| Androudi, S; Chatziralli, IP; Ladas, DS; Laios, K; Moschos, MM | 1 |
| Arifulin, EA; Azbukina, NV; Baksheeva, VE; Chistyakov, DV; Chistyakov, VV; Gancharova, OS; Goriainov, SV; Komarov, SV; Philippov, PP; Senin, II; Sergeeva, MG; Tikhomirova, NK; Tiulina, VV; Zamyatnin, AA; Zernii, EY | 1 |
| Kim, Y; Stanley, D | 1 |
| Cui, K; Feng, Y; Gu, L; Hu, J; Hu, Y; Huang, N; Li, G; Li, J; Li, W; Li, Y; Wang, X; Wu, W; Yu, J; Yue, C; Zeng, F; Zhao, F; Zhou, P | 1 |
70 review(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and arachidonic acid
| Article | Year |
|---|---|
Platelet-activating factor receptor and signal transduction.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Azepines; Cloning, Molecular; GTP-Binding Proteins; Humans; Molecular Sequence Data; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Second Messenger Systems; Sequence Homology, Amino Acid; Signal Transduction; Triazoles | 1992 |
Clinical relevance of lipid mediators in asthma.
Topics: Animals; Arachidonic Acid; Asthma; Humans; Leukotrienes; Lipids; Platelet Activating Factor; Prostaglandins; Thromboxanes | 1992 |
The role of transacylases in the metabolism of arachidonate and platelet activating factor.
Topics: Acetyl-CoA C-Acyltransferase; Arachidonic Acid; Humans; Lysophospholipids; Platelet Activating Factor | 1992 |
[Mediators and ARDS].
Topics: Arachidonic Acid; Blood Coagulation Disorders; Bronchoalveolar Lavage Fluid; Complement Activation; Cytokines; Endopeptidases; Free Radicals; Humans; Microbial Collagenase; Neutrophils; Platelet Activating Factor; Respiratory Distress Syndrome | 1991 |
Prospects for bronchodilating drugs in the 1990s.
Topics: Adrenergic beta-Agonists; Arachidonic Acid; Asthma; Bronchodilator Agents; Forecasting; Humans; Muscarine; Narcotics; Phosphodiesterase Inhibitors; Platelet Activating Factor; Potassium Channels; Signal Transduction | 1991 |
Arachidonic acid cascade and platelet-activating factor in the network of eye inflammatory mediators: therapeutic implications in uveitis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Autoimmunity; Endophthalmitis; Humans; Hypersensitivity; Inflammation; Platelet Activating Factor; Uveitis | 1990 |
Host responses in mediating sepsis and adult respiratory distress syndrome.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Coagulation; Complement System Proteins; Cross Infection; Cytokines; Endopeptidases; Humans; Intensive Care Units; Lipopolysaccharides; Liver; Multiple Organ Failure; Platelet Activating Factor; Pneumonia; Respiratory Distress Syndrome | 1990 |
Lipid metabolism and signal transduction in endothelial cells.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Endothelium; Fatty Acids; Humans; Lipid Metabolism; Platelet Activating Factor; Protein Kinases; Signal Transduction | 1990 |
Mediator release from human basophils and mast cells from lung and intestinal mucosa.
Topics: Antibodies, Anti-Idiotypic; Arachidonic Acid; Arachidonic Acids; Basophils; Histamine Release; Humans; Immunoglobulin E; Indomethacin; Intestinal Mucosa; Leukotriene B4; Lipoxygenase; Lung; Mast Cells; Peptide Hydrolases; Platelet Activating Factor; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins D; SRS-A | 1985 |
Mechanisms of glucocorticoid action in pulmonary disease.
Topics: Animals; Annexins; Arachidonic Acid; Arachidonic Acids; Asthma; Calcium-Binding Proteins; Chemotactic Factors; Glucocorticoids; Glycoproteins; Histamine Release; Humans; Inflammation; Lung; Lung Diseases; Platelet Activating Factor; Protein Biosynthesis; Pulmonary Gas Exchange; Receptors, Glucocorticoid; Status Asthmaticus | 1985 |
Role of paf-acether and related ether-lipid metabolism in platelets.
Topics: Acetyltransferases; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Cyclic AMP; Glycerylphosphorylcholine; Histamine Release; Humans; Hydrolysis; Phospholipases A; Platelet Activating Factor; Platelet Aggregation; Serotonin; Thrombin | 1985 |
Melanocytes, melanogenesis, and inflammation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Epidermal Cells; Humans; Inflammation; Keratins; Melanins; Melanocytes; Monophenol Monooxygenase; Phorbol Esters; Photosensitivity Disorders; Platelet Activating Factor; Prostaglandins; Swine | 1986 |
Mediators of acute lung injury in endotoxaemia.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cats; Cyclooxygenase Inhibitors; Endotoxins; Escherichia coli; Lung; Lung Diseases; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Shock, Septic; Thromboxane-A Synthase; Thromboxanes | 1989 |
[The chorion and decidua--morphology and biomolecular processes for their activation exemplified by premature rupture of the fetal membranes].
Topics: Arachidonic Acid; Arachidonic Acids; Chorion; Decidua; Dinoprost; Female; Fetal Membranes, Premature Rupture; Humans; Immunohistochemistry; Infant, Newborn; Interleukin-1; Platelet Activating Factor; Pregnancy; Uterine Contraction | 1989 |
The synthesis, catabolism, and pathophysiological role of platelet-activating factor.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Infections; Humans; Immune System Diseases; Immunity, Cellular; Inflammation; Platelet Activating Factor; Platelet Activation | 1989 |
The role of basophils and mast cells in the pathogenesis of pulmonary diseases.
Topics: Anaphylaxis; Arachidonic Acid; Arachidonic Acids; Asthma; Basophils; Blood Platelets; Bronchial Provocation Tests; Calmodulin; Cyclic AMP; Deuterium; Deuterium Oxide; Histamine Release; Humans; Lung Diseases; Mast Cells; Peptide Hydrolases; Phospholipids; Platelet Activating Factor; Platelet Factor 4; Prostaglandin D2; Prostaglandins D; Receptors, IgE; Receptors, Immunologic; Serotonin; Water | 1985 |
Activated neutrophils release mediators that may contribute to myocardial injury and dysfunction associated with ischemia and reperfusion.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cardiomyopathies; Coronary Disease; Eicosanoic Acids; Free Radicals; Humans; Lipoxygenase; Neutrophils; Oxygen; Platelet Activating Factor; Platelet Aggregation; Serotonin; SRS-A; Superoxides | 1988 |
The role of leukotrienes in allergen-induced late responses in allergic sheep.
Topics: Allergens; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Asthma; Bronchial Spasm; Disease Models, Animal; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Leukotriene B4; Models, Biological; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Sheep; SRS-A | 1988 |
Prostaglandins, leukotrienes, phospholipase, platelet activating factor, and cytokines: an integrated approach to inflammation of human skin.
Topics: Annexins; Arachidonic Acid; Arachidonic Acids; Dermatitis; Glycoproteins; Humans; Interleukin-1; Leukotriene B4; Lipoxygenase; Phospholipases; Platelet Activating Factor; Prostaglandins; Psoriasis | 1988 |
Modulation of vascular smooth muscle contraction by the endothelium.
Topics: Acetylcholine; Adenine Nucleotides; Animals; Arachidonic Acid; Arachidonic Acids; Blood Vessels; Catecholamines; Cattle; Dogs; Endothelium; Enzyme Activation; Free Radicals; Guanylate Cyclase; Hemodynamics; Hemostasis; Hormones; Humans; Muscle Proteins; Muscle, Smooth, Vascular; Nitric Oxide; Oxidation-Reduction; Phospholipases; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rabbits; Rats; Serotonin; Thrombin | 1986 |
Role of thromboxane A2.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Collagen; Epinephrine; Humans; Indomethacin; Kinetics; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Serotonin; Thrombin; Thromboxane A2; Thromboxane B2 | 1985 |
Pathobiology of animal platelets.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cyclic AMP; Endotoxins; Epinephrine; Epoprostenol; Glycoproteins; Platelet Activating Factor; Platelet Aggregation; Thrombocytopenia; von Willebrand Factor | 1985 |
Regulation of platelet phospholipid metabolism.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Diglycerides; Fatty Acids; Humans; Kinetics; Phosphatidylcholines; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipases A; Phospholipids; Platelet Activating Factor; Thrombin | 1985 |
Platelet-activating factor--a powerful lipid autacoid possibly involved in microangiopathy.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arteriosclerosis; Blood Platelets; Calmodulin; Capillary Permeability; Chemical Phenomena; Chemistry; Cyclic AMP; Diabetic Angiopathies; Endothelium; Humans; Microcirculation; Neutrophils; Platelet Activating Factor; Steroids; Thrombosis | 1986 |
Lipid-derived and other chemical mediators of inflammation in the lung.
Topics: Anaphylatoxins; Arachidonic Acid; Arachidonic Acids; Asthma; Eicosanoic Acids; Fatty Acids; Humans; Leukocytes; Leukotriene B4; Lung; Macrophage Activation; Mucus; Platelet Activating Factor; Pneumonia; Prostaglandin-Endoperoxide Synthases; Respiratory Distress Syndrome; SRS-A | 1987 |
Lipid mediators produced through the lipoxygenase pathway.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Humans; Hydroxyeicosatetraenoic Acids; Interleukin-1; Interleukin-2; Leukotriene B4; Lipid Metabolism; Lipoxygenase; Platelet Activating Factor; SRS-A; T-Lymphocytes | 1987 |
Mast cell-dependent immediate hypersensitivity responses.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Chemotaxis, Leukocyte; Enzyme Activation; Histamine; Humans; Hypersensitivity, Immediate; Mast Cells; Peptide Hydrolases; Phospholipids; Platelet Activating Factor; Prostaglandin D2; Prostaglandins D; SRS-A; Type C Phospholipases | 1986 |
Platelet-activating factor and the kidney.
Topics: Acetylation; Arachidonic Acid; Arachidonic Acids; Calcium; Capillary Permeability; Cardiac Output; Electrolytes; Enzyme Activation; Glomerular Filtration Rate; Hypotension; Kidney; Lipoxygenase; Lymphocyte Activation; Models, Biological; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Proteinuria; Regional Blood Flow; Respiration | 1986 |
The interaction of histamine with other bronchoconstrictor mediators.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Asthma; Bronchi; Histamine; Humans; Muscle Contraction; Platelet Activating Factor | 1987 |
Mast cell involvement in various inflammatory processes.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Basophils; Cytotoxicity, Immunologic; Granuloma; Humans; Hypersensitivity, Delayed; Mast Cells; Nervous System Physiological Phenomena; Platelet Activating Factor; Proteoglycans; Rhinitis, Allergic, Perennial | 1987 |
Allergy and pseudoallergy: an overview of basic mechanisms.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Basophils; Chemotaxis; Drug Hypersensitivity; Histamine; Humans; Hypersensitivity; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Inflammation; Mast Cells; Platelet Activating Factor | 1987 |
[Asthma and platelets].
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Blood Platelets; Drug Tolerance; Humans; Platelet Activating Factor | 1988 |
[Shock mediators and their antagonists as future therapeutic perspectives].
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Endothelium, Vascular; Free Radicals; Humans; Interleukin-1; Oxygen Consumption; Peptide Hydrolases; Platelet Activating Factor; Shock; Tumor Necrosis Factor-alpha | 1988 |
[Mediators of immunologic inflammation of the respiratory tract].
Topics: Allergens; Arachidonic Acid; Arachidonic Acids; Asthma; Blood Platelets; Bronchial Provocation Tests; Histamine; Humans; Inflammation; Kinins; Leukocytes; Leukotrienes; Macrophages; Mast Cells; Nasal Provocation Tests; Platelet Activating Factor; Prostaglandins; Respiratory Hypersensitivity; Rhinitis, Allergic, Seasonal | 1988 |
A role for PAF-acether (platelet-activating factor) in platelet-dependent vascular diseases?
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Humans; Hypersensitivity; Kidney Diseases; Platelet Activating Factor; Rabbits; Vascular Diseases | 1985 |
Mediators of inflammation.
Topics: Arachidonic Acid; Arachidonic Acids; Chemotactic Factors, Eosinophil; Complement Membrane Attack Complex; Complement Pathway, Alternative; Complement Pathway, Classical; Complement System Proteins; Factor XI; Factor XII; Histamine; Humans; Inflammation; Kininogens; Mast Cells; Platelet Activating Factor; Prekallikrein | 1985 |
Mast cell mediators with emphasis on intestinal mast cells.
Topics: Aging; Animals; Arachidonic Acid; Arachidonic Acids; Arylsulfatases; Chemotactic Factors; Cytoplasmic Granules; Food Hypersensitivity; Gastric Mucosa; Glycoside Hydrolases; Heparin; Histamine; Humans; Hypersensitivity, Immediate; Intestinal Mucosa; Intestines; Lysosomes; Mast Cells; Oligopeptides; Peptide Hydrolases; Peroxidases; Platelet Activating Factor; Proteoglycans; Receptors, Histamine; Serotonin; Skin; Substrate Specificity; Superoxide Dismutase; Superoxides; Tissue Distribution | 1984 |
Phospholipid metabolism and cell stimulus activation coupling in platelets and other blood cells.
Topics: Actins; Arachidonic Acid; Arachidonic Acids; Biological Evolution; Biological Transport; Blood Cells; Blood Platelets; Blood Vessels; Calcium; Cell Membrane; Diglycerides; Endoplasmic Reticulum; Hydrolysis; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lipid Bilayers; Lipids; Lysophosphatidylcholines; Lysophospholipids; Myosins; Organoids; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phospholipases A; Phospholipids; Platelet Activating Factor; Solubility; Type C Phospholipases; Water | 1984 |
Mediators of anaphylaxis and inflammation.
Topics: Anaphylaxis; Animals; Arachidonic Acid; Arachidonic Acids; Autacoids; Chemical Phenomena; Chemistry; Chemotactic Factors; Chemotactic Factors, Eosinophil; Histamine; Humans; Hydrolases; Inflammation; Leukocytes; Leukotriene B4; Mast Cells; Platelet Activating Factor; Prostaglandins; Serotonin; SRS-A; Structure-Activity Relationship; Thromboxanes; Vasoactive Intestinal Peptide | 1982 |
Mediators of immediate hypersensitivity.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Basophils; Chemotactic Factors, Eosinophil; Drug Interactions; Heparin; Histamine Release; Homeostasis; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Lipoxygenase; Lysosomes; Mast Cells; Mice; Peptide Hydrolases; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rabbits; Rats | 1983 |
Studies with purified human basophils and mast cells.
Topics: Arachidonic Acid; Arachidonic Acids; Basophils; Cell Separation; Histamine; Histamine Release; Humans; Leukotrienes; Mast Cells; Peptide Hydrolases; Platelet Activating Factor; Prostaglandin D2; Prostaglandins D; Receptors, IgE; Receptors, Immunologic | 1983 |
Inflammatory mediators and acute infections.
Topics: Arachidonic Acid; Arachidonic Acids; Complement Activation; Factor XII; Histamine; Humans; Infections; Inflammation; Neutrophils; Platelet Activating Factor; Receptors, Histamine H1; Receptors, Histamine H2; Shock, Septic | 1984 |
Mediators of hypersensitivity and inflammatory cells in the pathogenesis of bronchial asthma.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Asthma; Asthma, Exercise-Induced; Bronchitis; Chemotactic Factors; Humans; Hypersensitivity; Immunoglobulin E; Interleukin-8; Mast Cells; Platelet Activating Factor; SRS-A | 1983 |
The human lung mast cell.
Topics: Arachidonic Acid; Arachidonic Acids; Biotransformation; Bradykinin; Chemotaxis; Enzymes; Histamine; Humans; Lung; Lung Diseases; Mast Cells; Muscle, Smooth; Muscle, Smooth, Vascular; Oxidation-Reduction; Platelet Activating Factor; Serotonin | 1984 |
Inducible prostaglandin synthase in cell injury.
Topics: Animals; Arachidonic Acid; Enzyme Induction; Gene Expression; Humans; Ischemic Attack, Transient; Phospholipases A; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Second Messenger Systems; Wounds and Injuries | 1995 |
Multiple forms of phospholipase A2 in macrophages capable of arachidonic acid release for eicosanoid biosynthesis.
Topics: Animals; Arachidonic Acid; Calcium; Cell Line; Eicosanoids; Enzyme Activation; Isoenzymes; Lipopolysaccharides; Macrophages; Mice; Phospholipases A; Phospholipases A2; Platelet Activating Factor | 1995 |
Update on current models of HIV-related neuronal injury: platelet-activating factor, arachidonic acid and nitric oxide.
Topics: AIDS Dementia Complex; Arachidonic Acid; Cytokines; HIV Envelope Protein gp120; HIV Infections; Humans; Macrophages; Neurons; Nitric Oxide; Oxidative Stress; Platelet Activating Factor; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate | 1994 |
Platelet-activating factor antagonists and ocular inflammation.
Topics: Animals; Arachidonic Acid; Collagenases; Cornea; Gene Expression Regulation, Enzymologic; Keratitis; Platelet Activating Factor; RNA, Messenger | 1994 |
An overview of glucocorticoid anti-inflammatory actions.
Topics: Anti-Inflammatory Agents; Arachidonic Acid; Blood Vessels; Cytokines; Endothelium, Vascular; Epithelium; Glucocorticoids; Humans; Inflammation; Interleukins; Leukocyte Count; Leukocytes; Platelet Activating Factor; Steroids | 1993 |
Platelet-activating factor: receptors and signal transduction.
Topics: Animals; Arachidonic Acid; Calcium; Cell Membrane; GTP-Binding Proteins; Humans; Liver; Models, Biological; Phosphatidylinositols; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Structure, Secondary; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction | 1993 |
Activation of the phospholipase/cyclooxygenase cascade in the rabbit cornea by platelet-activating factor is challenged by PAF receptor antagonists.
Topics: Animals; Arachidonic Acid; Azepines; Cornea; Enzyme Activation; Phospholipases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prostaglandin-Endoperoxide Synthases; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles | 1995 |
Retrograde messengers, long-term potentiation and memory.
Topics: Animals; Arachidonic Acid; Carbon Monoxide; Long-Term Potentiation; Memory, Short-Term; Neurotransmitter Agents; Nitric Oxide; Platelet Activating Factor | 1995 |
Platelet-activating factor and somatostatin activate mitogen-activated protein kinase (MAP kinase) and arachidonate release.
Topics: Animals; Arachidonic Acid; Brain; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Platelet Activating Factor; Rats; Signal Transduction; Somatostatin | 1996 |
Retrograde messengers and long-term potentiation: a progress report.
Topics: Animals; Arachidonic Acid; Humans; Long-Term Potentiation; Neuronal Plasticity; Neurotransmitter Agents; Nitric Oxide; Platelet Activating Factor; Synaptic Transmission | 1996 |
Pathogenesis of preterm labor and preterm premature rupture of membranes associated with intraamniotic infection.
Topics: Amnion; Arachidonic Acid; Bacterial Infections; Cytokines; Female; Fetal Membranes, Premature Rupture; Humans; Infant, Newborn; Metalloendopeptidases; Obstetric Labor, Premature; Platelet Activating Factor; Pregnancy; Prostaglandins | 1997 |
Activation of 85 kDa PLA2 by eicosanoids in human neutrophils and eosinophils.
Topics: Arachidonic Acid; Eicosanoids; Enzyme Activation; Eosinophils; Humans; Neutrophils; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor | 1996 |
Mediators of mucosal inflammation: implications for therapy.
Topics: Arachidonic Acid; Cytokines; Eicosanoids; Humans; Inflammation Mediators; Inflammatory Bowel Diseases; Platelet Activating Factor | 1997 |
Systemic inflammatory response syndrome.
Topics: Arachidonic Acid; Cytokines; Endothelium; Enteral Nutrition; Humans; Leukocytes; Nitric Oxide; Platelet Activating Factor; Reactive Oxygen Species; Systemic Inflammatory Response Syndrome | 1997 |
Acyltransferases and transacylases involved in fatty acid remodeling of phospholipids and metabolism of bioactive lipids in mammalian cells.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Acyltransferases; Animals; Arachidonic Acid; Fatty Acids; Humans; Lipid Metabolism; Lysophospholipase; Mammals; Phospholipases A; Phospholipids; Platelet Activating Factor; Rats | 1997 |
[Analysis of chemical mediators involved in acute inflammatory reaction with the rat pleurisy model].
Topics: Animals; Arachidonic Acid; Capillary Permeability; Carrageenan; Cell Movement; Chemokines; Complement System Proteins; Disease Models, Animal; Eicosanoids; Histamine; Inflammation; Kallikrein-Kinin System; Male; Neutrophils; Platelet Activating Factor; Pleurisy; Rats; Zymosan | 1997 |
Lipid mediators in inflammatory disorders.
Topics: Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Fatty Acids, Omega-3; Humans; Inflammation; Inflammation Mediators; Leukotriene Antagonists; Lipid Metabolism; Lipoxygenase Inhibitors; Phospholipases A; Phospholipases A2; Phospholipids; Platelet Activating Factor; Prostaglandins | 1998 |
Adenosine. An endogenous inhibitor of arachidonic acid release and leukotriene biosynthesis in human neutrophils.
Topics: Adenosine; Animals; Arachidonic Acid; Humans; Leukotriene B4; Neutrophils; Phosphodiesterase Inhibitors; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Theophylline | 1999 |
Investigations into the polydeterminant nature of sepsis.
Topics: Animals; Arachidonic Acid; Eicosanoids; Heart Diseases; Humans; Hypertension, Pulmonary; Platelet Activating Factor; Shock, Septic; Tumor Necrosis Factor-alpha | 1999 |
[Inflammatory mediators (leukotrienes, thromboxane A2, tachykinins and others)].
Topics: Arachidonic Acid; Asthma; Endothelins; Humans; Inflammation Mediators; Leukotriene Antagonists; Leukotrienes; Membrane Proteins; Platelet Activating Factor; Receptors, Leukotriene; Tachykinins; Thromboxane A2 | 2001 |
Oxidative stress and cell signalling.
Topics: Aldehydes; Animals; Arachidonic Acid; Cell Communication; Growth Substances; Humans; Isoprostanes; Linoleic Acid; Lipid Metabolism; Lysophospholipids; Oxidation-Reduction; Oxidative Stress; Platelet Activating Factor; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Reactive Oxygen Species; Signal Transduction; Transcription Factors | 2004 |
Lipids and two-pore domain K+ channels in excitable cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Endocannabinoids; Heart Ventricles; Hippocampus; Humans; Lipid Metabolism; Lipoxygenase; Memory; Mice; Myocytes, Cardiac; Nerve Tissue Proteins; Neurons; Platelet Activating Factor; Polyunsaturated Alkamides; Potassium Channels; Potassium Channels, Tandem Pore Domain; Protein Structure, Tertiary; Signal Transduction; Synaptic Transmission; Time Factors | 2005 |
The arachidonic acid pathway and its role in prostate cancer development and progression.
Topics: Animals; Annexins; Arachidonic Acid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Disease Progression; Group II Phospholipases A2; Humans; Lipoxygenase; Male; Oxygenases; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Prostatic Neoplasms | 2008 |
Significance of lipid mediators in corneal injury and repair.
Topics: Animals; Arachidonic Acid; Cornea; Corneal Injuries; Humans; Inflammation; Lipid Metabolism; Platelet Activating Factor; Wound Healing | 2010 |
Emerging roles of secreted phospholipase A(2) enzymes: an update.
Topics: Animals; Arachidonic Acid; Atherosclerosis; Catalysis; Fatty Acids, Nonesterified; Glycerophospholipids; Humans; Hydrolysis; Inflammation; Mice; Phospholipases A2, Secretory; Platelet Activating Factor | 2013 |
Eicosanoid Signaling in Insect Immunology: New Genes and Unresolved Issues.
Topics: Animals; Arachidonic Acid; Eicosanoids; Fatty Acid Desaturases; Hemocytes; Insecta; Lipoxygenase; Mammals; Phospholipases A2; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Signal Transduction | 2021 |
5 trial(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and arachidonic acid
| Article | Year |
|---|---|
Effect of diltiazem and low-dose aspirin on platelet aggregation and ATP release induced by paired agonists.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Arachidonic Acid; Aspirin; Bleeding Time; Blood Platelets; Diltiazem; Drug Synergism; Epinephrine; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors | 1993 |
Platelet responses to several agonists and combinations of agonists in whole blood: a placebo controlled comparison of the effects of a once daily dose of plain aspirin 300 mg, plain aspirin 75 mg and enteric coated aspirin 300 mg, in man.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Coagulants; Collagen; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; Male; Placebos; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Ristocetin; Streptokinase; Tablets, Enteric-Coated | 1997 |
The inhibitory effect of cinchonine on human platelet aggregation due to blockade of calcium influx.
Topics: Adenosine Diphosphate; Antimalarials; Arachidonic Acid; Calcimycin; Calcium; Cinchona Alkaloids; Collagen; Epinephrine; Humans; Platelet Activating Factor; Platelet Aggregation Inhibitors; Reference Values; Signal Transduction | 1998 |
Effect of fast-food Mediterranean-type diet on type 2 diabetics and healthy human subjects' platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Blood Platelets; Body Weight; Diabetes Mellitus, Type 2; Diet; Diet, Mediterranean; Energy Intake; Food Analysis; Humans; Lipids; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Reference Values; Restaurants | 2006 |
Effect of traditional Greek Mediterranean meals on platelet aggregation in normal subjects and in patients with type 2 diabetes mellitus.
Topics: Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Diabetes Mellitus, Type 2; Diet, Mediterranean; Female; Greece; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Thrombin | 2006 |
448 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and arachidonic acid
| Article | Year |
|---|---|
Platelet adhesion and aggregation in diabetes mellitus.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Blood Coagulation Factors; Blood Platelets; Diabetes Mellitus; Factor VIII; Humans; Imidazoles; Insulin; Male; Platelet Activating Factor; Platelet Adhesiveness; Platelet Aggregation; von Willebrand Factor | 1979 |
[Effects of platelet activating factor on the cerebrovascular permeability in rats and the protection by drug].
Topics: Animals; Arachidonic Acid; Brain; Capillary Permeability; Cattle; Cells, Cultured; Female; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Platelet Activating Factor; Pyrans; Rats; Rats, Wistar | 1992 |
Bacterial lipopolysaccharide up-regulates platelet-activating factor-stimulated Ca2+ mobilization and eicosanoid release in human Mono Mac 6 cells.
Topics: Antigens, Surface; Arachidonic Acid; Calcium; Cells, Cultured; Eicosanoids; Humans; Lipopolysaccharides; Macrophages; Monocytes; Phagocytosis; Platelet Activating Factor; Signal Transduction; Superoxides; Thromboxane B2; Up-Regulation | 1992 |
Salmonella typhimurium porins stimulate platelet-activating factor synthesis by human polymorphonuclear neutrophils.
Topics: Arachidonic Acid; Bacterial Outer Membrane Proteins; Calcium; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Space; Humans; In Vitro Techniques; Neutrophils; Platelet Activating Factor; Porins; Salmonella typhimurium; Time Factors | 1992 |
Arachidonic acid release and platelet-activating factor formation by staurosporine in human neutrophils challenged with n-formyl peptide.
Topics: Alkaloids; Arachidonic Acid; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Protein Kinase C; Staurosporine | 1992 |
Platelet-activating factor stimulates multiple signaling pathways in cultured rat mesangial cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Arachidonic Acid; Cells, Cultured; Cyclic AMP; Glomerular Mesangium; Guanosine 5'-O-(3-Thiotriphosphate); Male; Pertussis Toxin; Phosphatidylinositols; Phospholipases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Virulence Factors, Bordetella | 1992 |
Regulation of leukotriene biosynthesis in human polymorphonuclear leukocytes.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcium; Chromatography, High Pressure Liquid; Egtazic Acid; Fluorescent Dyes; Fura-2; Humans; Ionomycin; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor | 1992 |
Activation of NADPH oxidase and phospholipase D in permeabilized human neutrophils. Correlation between oxidase activation and phosphatidic acid production.
Topics: Adenine Nucleotides; Adult; Analysis of Variance; Arachidonic Acid; Bacterial Toxins; Calcium; Cell Membrane Permeability; Diglycerides; Enzyme Activation; Ethanol; Guanosine 5'-O-(3-Thiotriphosphate); Hemolysin Proteins; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phosphatidic Acids; Phospholipase D; Platelet Activating Factor; Reference Values; Second Messenger Systems; Staphylococcus aureus; Superoxides | 1992 |
Modulation of arachidonic acid metabolism and cyclic AMP content of human alveolar macrophages.
Topics: Adult; Aged; Aged, 80 and over; Arachidonic Acid; Calcimycin; Cell Count; Cells, Cultured; Cyclic AMP; Cyclooxygenase Inhibitors; Female; Humans; Lipoxygenase Inhibitors; Macrophage Activation; Macrophages, Alveolar; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic | 1992 |
Blockade of thromboxane/endoperoxide receptor-mediated responses in the pulmonary vascular bed of the cat by sulotroban.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Arachidonic Acid; Blood Pressure; Cats; Endothelins; Female; Histamine; Lung; Male; Norepinephrine; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Receptors, Prostaglandin; Receptors, Thromboxane; Serotonin; Sulfonamides | 1992 |
Daltroban blocks thromboxane responses in the pulmonary vascular bed of the cat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Blood Pressure; Cats; Endothelins; Female; Male; Phenylacetates; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Receptors, Prostaglandin; Receptors, Thromboxane; Serotonin; Sulfonamides; Thromboxane A2; Vasoconstrictor Agents | 1992 |
Effects of ozone exposure on lipid metabolism in human alveolar macrophages.
Topics: Adult; Arachidonic Acid; Humans; In Vitro Techniques; Lipid Metabolism; Macrophages, Alveolar; Male; Ozone; Platelet Activating Factor; Prostaglandins | 1992 |
Inhibition by azelastine of the effects of platelet-activating factor in lungs from actively sensitised guinea-pigs.
Topics: Animals; Arachidonic Acid; Bronchoconstriction; Guinea Pigs; Histamine; Immunization; Injections, Intra-Arterial; Leukotrienes; Lung; Male; Ovalbumin; Phthalazines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pulmonary Artery; Thromboxane B2 | 1992 |
A novel CoA-independent transacetylase produces the ethanolamine plasmalogen and acyl analogs of platelet-activating factor (PAF) with PAF as the acetate donor in HL-60 cells.
Topics: Acetates; Acetyltransferases; Arachidonic Acid; Calcimycin; Calcium; Cations, Divalent; Cell Membrane; Cells, Cultured; Chromatography, Thin Layer; Hydrogen-Ion Concentration; Magnesium; Phenylmethylsulfonyl Fluoride; Phospholipids; Plasmalogens; Platelet Activating Factor; Substrate Specificity; Temperature | 1992 |
Pharmacological modulation of the late eosinophilia induced by antigen in actively sensitized rats.
Topics: Animals; Antigens; Arachidonic Acid; Cyclooxygenase Inhibitors; Eosinophilia; Female; Leukocyte Count; Lipoxygenase Inhibitors; Male; Ovalbumin; Platelet Activating Factor; Pleurisy; Rats; Rats, Wistar | 1992 |
Platelet-activating factor stimulates arachidonic acid release and enhances thromboxane B2 production in intact fetal rat brain ex vivo.
Topics: Animals; Arachidonic Acid; Brain Chemistry; Calcium; Fetus; Humans; Phospholipids; Platelet Activating Factor; Rats; Rats, Wistar; Telencephalon; Thromboxane B2 | 1992 |
Gamma-pyrone compounds. II: Synthesis and antiplatelet effects of tetraoxygenated xanthones.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Cells, Cultured; Collagen; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Structure-Activity Relationship; Xanthenes | 1992 |
Evidence for different mechanisms involved in the formation of lyso platelet-activating factor and the calcium-dependent release of arachidonic acid from human neutrophils.
Topics: Acyltransferases; Arachidonic Acid; Calcium; Cell Membrane; Humans; Neutrophils; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Phospholipids; Platelet Activating Factor | 1992 |
Effects of thromboxane synthase and cyclooxygenase inhibition on PAF-induced changes in lung function and arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Body Fluids; Imidazoles; Lung; Meclofenamic Acid; Pilot Projects; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Respiratory Mechanics; Sheep; Tetrahydronaphthalenes; Thromboxane-A Synthase | 1992 |
Vascular effects of platelet-activating factor in lambs: role of cyclo- and lipoxygenase.
Topics: Anesthesia; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Blood Pressure; Cardiac Output; Hemodynamics; Hydrogen-Ion Concentration; In Vitro Techniques; Lung; Microcirculation; Perfusion; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Pulmonary Circulation; Sheep; Structure-Activity Relationship; Vascular Resistance | 1992 |
Cell response kinetics: the phenomenon of supercooperativity in aggregation of human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Calcimycin; Epinephrine; Humans; Kinetics; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Tetradecanoylphorbol Acetate; Thimerosal | 1992 |
Antiplatelet actions of some coumarin compounds isolated from plant sources.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acid; Blood Platelets; Coumarins; Membrane Lipids; Molecular Structure; Phospholipids; Plants; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Rabbits; Thrombin; Thromboxane B2 | 1992 |
Factors that influence the proportions of platelet-activating factor and 1-acyl-2-acetyl-sn-glycero-3-phosphocholine synthesized by the mast cell.
Topics: Animals; Arachidonic Acid; Calcimycin; Cells, Cultured; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Mast Cells; Mice; Mice, Inbred CBA; Phenylmethylsulfonyl Fluoride; Phosphorus; Platelet Activating Factor | 1992 |
Sphingosine enhances platelet aggregation through an increase in phospholipase C activity by a protein kinase C-independent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Calcium; Cell Membrane; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; Piperazines; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Rabbits; Sphingosine; Staurosporine; Thrombin; Type C Phospholipases | 1992 |
The effects of varying doses of aspirin on human platelet activation induced by PAF, collagen and arachidonic acid.
Topics: Adenosine Triphosphate; Adult; Arachidonic Acid; Aspirin; Collagen; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Sex Factors | 1992 |
Stimulation of human airway epithelial cells by platelet activating factor (PAF) and arachidonic acid produces 15-hydroxyeicosatetraenoic acid (15-HETE) capable of contracting bronchial smooth muscle.
Topics: Arachidonic Acid; Bronchi; Bronchoconstriction; Epithelial Cells; Epithelium; Humans; Hydroxyeicosatetraenoic Acids; Platelet Activating Factor | 1992 |
Heterogeneity of arachidonate and paf-acether precursor pools in mast cells.
Topics: Acetyltransferases; Animals; Antibodies, Monoclonal; Arachidonic Acid; Bone Marrow; Dinitrophenols; Fatty Acids; Femur; Lipid Metabolism; Mast Cells; Mice; Mice, Inbred BALB C; Phosphatidylcholines; Platelet Activating Factor; Serum Albumin, Bovine; Substrate Specificity; Tibia | 1992 |
Synthesis of platelet activating factor and metabolism of related lipids in embryonic cells.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Chromatography, Thin Layer; Lipid Metabolism; Mice; Palate; Phospholipases; Platelet Activating Factor | 1992 |
Inhibition by glaucocalyxin A of aggregation of rabbit platelets induced by ADP, arachidonic acid and platelet-activating factor, and inhibition of [3H]-PAF binding.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Blood Platelets; Diterpenes, Kaurane; Drugs, Chinese Herbal; Female; Glyceryl Ethers; In Vitro Techniques; Kinetics; Male; Molecular Structure; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thiazoles | 1992 |
Modulation of arachidonic acid metabolism in cultured rat astroglial cells by long-chain N-3 fatty acids.
Topics: Animals; Arachidonic Acid; Astrocytes; Calcimycin; Cells, Cultured; Eicosanoids; Fatty Acids, Unsaturated; Platelet Activating Factor; Rats | 1992 |
Calcium-dependent biosynthesis of platelet-activating factor by submandibular gland cells.
Topics: Acetylcholine; Acetyltransferases; Animals; Arachidonic Acid; Arachidonic Acids; Atropine; Calcium; Diacylglycerol Cholinephosphotransferase; Dithiothreitol; Dogs; Female; In Vitro Techniques; Kinetics; Male; Pirenzepine; Platelet Activating Factor; Submandibular Gland | 1991 |
Effects of okadaic acid on agonist-stimulated PGI2 production by rat liver cells (the C-9 cell line).
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Ethers, Cyclic; Kinetics; Liver; Okadaic Acid; Phosphoprotein Phosphatases; Platelet Activating Factor; Prostaglandins F; Radioimmunoassay; Rats; Tetradecanoylphorbol Acetate; Thrombin | 1991 |
The effect of lipoproteins on the release of some eicosanoids by stimulated human leukocytes. A possible role in atherogenesis.
Topics: Arachidonic Acid; Calcimycin; Dextran Sulfate; Dinoprostone; Fatty Acids; Humans; Hydroxyeicosatetraenoic Acids; Leukocytes; Leukotriene B4; Lipoproteins, LDL; Platelet Activating Factor | 1991 |
Thrombin-activated platelets promote leukotriene B4 synthesis in polymorphonuclear leucocytes stimulated by physiological agonists.
Topics: Arachidonate 12-Lipoxygenase; Arachidonic Acid; Blood Platelets; Humans; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Activation; Thrombin | 1991 |
Receptor-mediated activation of arachidonic acid release in mouse peritoneal macrophages is linked to extracellular calcium influx.
Topics: Animals; Arachidonic Acid; Calcium; Cells, Cultured; Egtazic Acid; Kinetics; Macrophages; Mice; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Receptors, Cell Surface; Verapamil; Zymosan | 1991 |
Comparison of the role of protein kinase C in platelet functional responses induced by three different mechanisms, PAF, ionomycin and arachidonic acid.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium; Feedback; Ionomycin; Phosphorylation; Platelet Activating Factor; Platelet Activation; Platelet Membrane Glycoproteins; Protein Kinase C; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1991 |
Transcellular metabolism of arachidonic acid in platelets and polymorphonuclear leukocytes activated by physiological agonists: enhancement of leukotriene B4 synthesis.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Blood Platelets; Humans; In Vitro Techniques; Kinetics; Leukotriene B4; Models, Biological; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Activation; Thrombin | 1991 |
Platelet-activating factor may participate in signal transduction processes in rabbit leukocytes.
Topics: Animals; Arachidonic Acid; Azepines; Blood Platelets; Calcimycin; Chloroquine; Female; Kinetics; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Pyridinium Compounds; Rabbits; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Triazoles | 1991 |
Platelet-activating factor (PAF) receptor antagonists inhibit arachidonic acid induced platelet aggregation in rabbit whole blood.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Azepines; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazoles | 1991 |
Effects of anti-inflammatory drugs on rat hind-paw swelling caused by phospholipase A2 from Naja naja atra venom.
Topics: Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Edema; Elapid Venoms; Histamine; Kinins; Leukocytes, Mononuclear; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Rats, Inbred Strains; Serotonin; Time Factors | 1991 |
Biosynthesis of platelet-activating factor (PAF) in human polymorphonuclear leucocytes. The role of lyso-PAF disposal and free arachidonic acid.
Topics: 1-Methyl-3-isobutylxanthine; Acetyltransferases; Acyltransferases; Arachidonic Acid; Arachidonic Acids; Calcimycin; Coenzyme A Ligases; Fatty Acids; Humans; Kinetics; Leukotriene B4; Neutrophils; Platelet Activating Factor; Theophylline | 1990 |
Comparative study of the effect of CV-6209, a specific PAF-antagonist, on rat paw edema caused by different phlogogen agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Carrageenan; Dextrans; Edema; Histamine Antagonists; Male; p-Methoxy-N-methylphenethylamine; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Inbred Strains; Serotonin Antagonists; Zymosan | 1990 |
Endotoxin-induced impairment of vascular reactivity in the pithed rat: role of arachidonic acid metabolites.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Cyclooxygenase Inhibitors; Dinoprostone; Electric Stimulation; Endotoxins; Epoprostenol; Flurbiprofen; Hemodynamics; Iloprost; Male; Norepinephrine; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Spinal Cord; Sympathetic Nervous System | 1990 |
Protein kinase C and cyclic AMP modulate thrombin-induced platelet-activating factor synthesis in human endothelial cells.
Topics: Acetyltransferases; Arachidonic Acid; Arachidonic Acids; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Endothelium, Vascular; Humans; Iloprost; Ionomycin; Kinetics; Platelet Activating Factor; Protein Kinase C; Tetradecanoylphorbol Acetate; Thrombin | 1991 |
Lipid mediators contribute to oxygen-radical-induced airway responses in sheep.
Topics: Animals; Arachidonic Acid; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Eicosanoids; Female; Free Radical Scavengers; Free Radicals; Oxygen; Platelet Activating Factor; Premedication; Sheep | 1991 |
[The interaction of platelet and vascular endothelial cell].
Topics: Angiogenesis Inducing Agents; Arachidonic Acid; Blood Coagulation Factors; Blood Platelets; Cell Communication; Cell Division; Endothelins; Endothelium, Vascular; Epoprostenol; Heparan Sulfate Proteoglycans; Heparitin Sulfate; Humans; Nitric Oxide; Platelet Activating Factor; Platelet Aggregation; Proteoglycans; Thromboxane A2 | 1991 |
[Roles of arachidonic acid cascade and related substances in respiratory diseases].
Topics: Animals; Arachidonic Acid; Asthma; Bronchi; Humans; Lung Diseases; Macrophages; Muscle Tonus; Platelet Activating Factor; Pulmonary Fibrosis; Respiratory Tract Diseases; Sarcoidosis; Smoking | 1991 |
The lyso-precursor of platelet-activating factor (lyso-PAF) in ischaemic myocardium.
Topics: Acetylation; Animals; Arachidonic Acid; Blood Platelets; Coronary Disease; Dogs; Kinetics; Myocardium; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Serotonin; Type C Phospholipases | 1991 |
Arachidonic acid cycloxygenase and lipoxygenase pathways are differently activated by platelet activating factor and the calcium-ionophore A23187 in a primary culture of astroglial cells.
Topics: Animals; Arachidonic Acid; Astrocytes; Calcimycin; Cells, Cultured; Diglycerides; Fatty Acids, Nonesterified; Hydrolysis; Lipoxygenase; Phospholipids; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rats | 1991 |
Stimulation of human airway epithelial cells by platelet activating factor (PAF) and arachidonic acid produces 15-hydroxyeicosatetraenoic acid (15-HETE) capable of contracting bronchial smooth muscle.
Topics: Arachidonic Acid; Bronchi; Chromatography, High Pressure Liquid; Epithelial Cells; Epithelium; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Platelet Activating Factor; Protein Biosynthesis; Stimulation, Chemical | 1991 |
Arachidonic acid cyclo and lipoxygenase pathways in astroglial cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Astrocytes; Calcimycin; Cells, Cultured; Diglycerides; Eicosanoids; Fatty Acids, Nonesterified; Hydroxyeicosatetraenoic Acids; Lipoxygenase; Platelet Activating Factor; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Thromboxane B2 | 1991 |
Granulocyte-macrophage colony-stimulating factor increases the synthesis of leukotriene B4 by human neutrophils in response to platelet-activating factor. Enhancement of both arachidonic acid availability and 5-lipoxygenase activation.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Diterpenes; Enzyme Activation; Ginkgolides; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Lactones; Leukotriene B4; Neutrophils; Platelet Activating Factor | 1991 |
Tumor necrosis factor-alpha priming of phospholipase A2 activation in human neutrophils. An alternative mechanism of priming.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Cytochalasin B; Diglycerides; Enzyme Activation; Humans; Leukotriene B4; Membrane Lipids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Platelet Activating Factor; Tumor Necrosis Factor-alpha | 1991 |
Recombinant human interleukin-8 is a potent activator of canine neutrophil aggregation, migration, and leukotriene B4 biosynthesis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Aggregation; Chemotaxis, Leukocyte; Cycloheximide; Dogs; Humans; Injections, Intradermal; Interleukin-1; Interleukin-8; Kinetics; Leukotriene B4; Neutrophils; Platelet Activating Factor; Recombinant Proteins; Skin | 1991 |
Platelet-activating factor induces phospholipid turnover, calcium flux, arachidonic acid liberation, eicosanoid generation, and oncogene expression in a human B cell line.
Topics: Arachidonic Acid; Arachidonic Acids; B-Lymphocytes; Calcium; Cell Line, Transformed; DNA-Binding Proteins; Eicosanoids; Gene Expression Regulation; Herpesvirus 4, Human; Humans; Hydroxyeicosatetraenoic Acids; Membrane Lipids; Phospholipids; Phosphorus Radioisotopes; Platelet Activating Factor; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Transcription Factors; Up-Regulation | 1991 |
PAF receptor mediated PGE2 production in LPS primed P388D1 macrophage-like cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cycloheximide; Cyclooxygenase Inhibitors; Dactinomycin; Dinoprostone; Enzyme Activation; Gene Expression Regulation, Neoplastic; Genistein; Isoflavones; Lipopolysaccharides; Macrophages; Mice; Phospholipases A; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Tumor Cells, Cultured | 1991 |
[PAF synthesis and its regulation].
Topics: Acetyltransferases; Animals; Arachidonic Acid; Arachidonic Acids; Diacylglycerol Cholinephosphotransferase; Inflammation; Kidney; Macrophages; Neutrophils; Platelet Activating Factor; Spleen | 1991 |
Nitroprusside in vitro inhibits platelet aggregation and intracellular calcium translocation. Effect of haemoglobin.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Collagen; Hemoglobins; Humans; In Vitro Techniques; Intracellular Fluid; Nitroprusside; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors | 1991 |
[Phospholipid metabolism in vascular endothelial cells].
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Endothelium, Vascular; Humans; Phospholipids; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases | 1991 |
[The metabolism of glycerophospholipids and its regulation of macrophages].
Topics: Acylation; Animals; Arachidonic Acid; Arachidonic Acids; Eicosanoids; Fatty Acids; Humans; Macrophage Activation; Macrophages; Phospholipids; Platelet Activating Factor | 1991 |
Some properties of rat platelet aggregation and effects of butylated hydroxytoluene, warfarin and aspirin.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Coagulation Factors; Butylated Hydroxytoluene; Collagen; Epinephrine; Male; Platelet Activating Factor; Platelet Aggregation; Rats; Rats, Inbred Strains; Ristocetin; Warfarin | 1991 |
Selective inhibition of vasoconstrictor responses by platelet-activating factor in rat kidney.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Calcium Channel Blockers; Dopamine Antagonists; Dose-Response Relationship, Drug; Furans; Gallic Acid; Haloperidol; Hematocrit; Male; Nimodipine; Platelet Activating Factor; Potassium Chloride; Rats; Rats, Inbred Strains; Renal Circulation; Vasoconstriction | 1991 |
Detection of platelet desensitization in pregnancy-induced hypertension is dependent on the agonist used.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Collagen; Female; Humans; Hypertension; Platelet Activating Factor; Platelet Aggregation; Pregnancy; Pregnancy Complications, Cardiovascular; Reference Values | 1991 |
Antagonism of PAF and arachidonic acid by ketotifen.
Topics: Arachidonic Acid; Arachidonic Acids; Humans; Ketotifen; Platelet Activating Factor | 1991 |
Biosynthesis of platelet activating factor and 1-O-acyl analogues by endothelial cells.
Topics: Acetylation; Arachidonic Acid; Arachidonic Acids; Endothelium, Vascular; Humans; Phosphatidylcholines; Platelet Activating Factor; Spectrometry, Mass, Fast Atom Bombardment; Umbilical Veins | 1991 |
Influence of SK&F 96148 on thromboxane-mediated responses in the airways of the cat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Airway Resistance; Animals; Arachidonic Acid; Arachidonic Acids; Cats; Endothelins; Endotoxins; Escherichia coli; Female; Male; Phenylacetates; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Respiratory Physiological Phenomena; Respiratory System; Sulfonamides; Thromboxane A2; Thromboxanes | 1991 |
Platelet aggregation in recombinant-hirudin-anticoagulated blood.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Citrates; Citric Acid; Collagen; Drug Synergism; Epinephrine; Hirudins; Humans; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Recombinant Proteins; Serotonin | 1991 |
Gastric bleeding and increased gastric vascular permeability induced by platelet activating factor (PAF): effect of drugs that affect arachidonate metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Caffeic Acids; Capillary Permeability; Dinoprostone; Gastric Mucosa; Gastrointestinal Hemorrhage; Hydrocortisone; Imidazoles; Indomethacin; Male; Perfusion; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains | 1991 |
Leukotrienes in brain: natural occurrence and induced changes.
Topics: Administration, Oral; Animals; Arachidonic Acid; Body Temperature; Brain Chemistry; Cats; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Cyclooxygenase Inhibitors; Dinoprostone; Female; In Vitro Techniques; Injections, Intraventricular; Leukotrienes; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Pyrogens; Radioimmunoassay; Thromboxane B2 | 1991 |
Changes of rabbit platelet function on simultaneous administration of ticlopidine hydrochloride and OKY-046.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arachidonic Acid; Collagen; Drug Interactions; Drug Synergism; Methacrylates; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Statistics as Topic; Ticlopidine | 1991 |
Differential inhibition by nedocromil sodium of superoxide generation elicited by platelet activating factor in human neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Nedocromil; Neutrophils; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Quinolones; Superoxides | 1990 |
Benzodiazepine analogues inhibit arachidonate-induced aggregation and thromboxane synthesis in human platelets.
Topics: Arachidonic Acid; Arachidonic Acids; Benzodiazepines; Blood Coagulation Factors; Blood Platelets; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, GABA-A; Thromboxanes | 1990 |
Novel interactions between second messengers in rat basophilic leukaemia (RBL-1) cells.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Cyclic AMP; Enzyme Activation; Inositol Phosphates; Leukemia, Basophilic, Acute; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Second Messenger Systems; SRS-A; Tumor Cells, Cultured; Type C Phospholipases | 1990 |
Enhancement of platelet-activating factor-induced leukotriene synthesis in neutrophils by granulocyte-macrophage colony-stimulating factor (GM-CSF): studies on the mechanism of action of GM-CSF.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Drug Synergism; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Leukotriene B4; Leukotrienes; Lipid Peroxides; Neutrophils; Platelet Activating Factor | 1990 |
Effect of histamine receptor blockers on human platelet aggregation.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Collagen; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Aggregation | 1990 |
The combined effects of N-3 fatty acids and aspirin on hemostatic parameters in man.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Bleeding Time; Collagen; Depression, Chemical; Drug Synergism; Fish Oils; Hemostasis; Humans; Male; Platelet Activating Factor; Platelet Aggregation | 1990 |
The correlation between Ca2+ influx and inositol 1, 4, 5-trisphosphate (IP3) formation in platelets stimulated by various agonists.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Humans; Inositol 1,4,5-Trisphosphate; Ionomycin; Platelet Activating Factor; Temperature; Thrombin; Thromboxane A2 | 1990 |
An arachidonoyl (polyenoic)-specific phospholipase A2 activity regulates the synthesis of platelet-activating factor in granulocytic HL-60 cells.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Differentiation; Cyclooxygenase Inhibitors; Dimethyl Sulfoxide; Fatty Acids, Unsaturated; Granulocytes; Humans; Lipoxygenase Inhibitors; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipases; Phospholipases A; Phospholipases A2; Phospholipids; Platelet Activating Factor; Tumor Cells, Cultured | 1990 |
Cooperativity between platelet-activating factor and collagen in aggregation of bovine platelets III.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cattle; Collagen; Drug Synergism; Phospholipids; Platelet Activating Factor; Platelet Aggregation | 1990 |
A comparative study of the effects of local anaesthetics on platelet aggregation.
Topics: Adenosine Diphosphate; Anesthetics, Local; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Humans; In Vitro Techniques; Membrane Lipids; Platelet Activating Factor; Platelet Aggregation | 1990 |
Evidence that increasing the cellular content of eicosapentaenoic acid does not reduce the biosynthesis of platelet-activating factor.
Topics: Acylation; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Dietary Fats; Eicosapentaenoic Acid; Fish Oils; In Vitro Techniques; Mast Cells; Mice; Neutrophils; Phosphatidylcholines; Platelet Activating Factor | 1990 |
Mechanism of N-formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-induced arachidonic acid release in guinea pig alveolar macrophages: involvement of a GTP-binding protein and role of protein kinase A and protein kinase C.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Down-Regulation; GTP-Binding Proteins; Guinea Pigs; Isoquinolines; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Pulmonary Alveoli; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1990 |
Effect of nicergoline on platelet aggregation, plasma viscosity and erythrocyte deformability in geriatric patients with cerebral infarction. Preliminary report.
Topics: Aged; Arachidonic Acid; Arachidonic Acids; Blood Viscosity; Cerebral Infarction; Collagen; Erythrocyte Deformability; Female; Humans; Male; Middle Aged; Nicergoline; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors | 1990 |
Ether lysophospholipid-induced production of platelet-activating factor in human polymorphonuclear leukocytes.
Topics: Acetates; Acetyl Coenzyme A; Arachidonic Acid; Arachidonic Acids; Calcimycin; Humans; In Vitro Techniques; Kinetics; Neutrophils; Platelet Activating Factor; Zymosan | 1990 |
Production of 15-hydroxyeicosatetraenoic acid by purified human eosinophils and neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Separation; Complement C5a; Eosinophils; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor | 1990 |
Enhanced arachidonic acid metabolism and human neutrophil migration in asthma.
Topics: Adolescent; Adult; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Asthma; Calcimycin; Chemotaxis, Leukocyte; Humans; Leukotrienes; Middle Aged; Neutrophils; Platelet Activating Factor | 1990 |
Macrophage activation reduces mobilization of arachidonic acid by guinea-pig and rat peritoneal macrophages in vitro.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Calcimycin; Epoprostenol; Guinea Pigs; Macrophage Activation; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Peritoneal Cavity; Platelet Activating Factor; Rats; Rats, Inbred Strains; Zymosan | 1990 |
Arachidonic acid activates Ca2+ extrusion in macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Calcium-Transporting ATPases; Carrier Proteins; Cell Membrane; Macrophage Activation; Macrophages; Mice; Nucleotides, Cyclic; Platelet Activating Factor; Protein Kinase C; Sodium; Sodium-Calcium Exchanger; Terpenes; Thapsigargin | 1990 |
Effects of platelet activating factor antagonists on arachidonic acid-induced platelet aggregation and TXA2 formation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Azepines; Blood Platelets; Diterpenes; Ginkgolides; Imidazoles; In Vitro Techniques; Lactones; Naphthalenes; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Triazoles | 1990 |
Identification of a novel and highly potent eosinophil chemotactic lipid in human eosinophils treated with arachidonic acid.
Topics: Arachidonate 15-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cells, Cultured; Chemotactic Factors; Chemotaxis, Leukocyte; Eosinophils; Glutathione; Humans; In Vitro Techniques; Leukotriene B4; Lipids; Magnesium; Platelet Activating Factor; Structure-Activity Relationship | 1990 |
Inhibition of rabbit platelet aggregation by 1,4-naphthoquinones.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Calcium; Collagen; Naphthoquinones; Phosphatidylinositols; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thrombin; Thromboxane A2 | 1990 |
Cytotoxic enzyme release and oxygen centered radical formation in human neutrophils are selectively inhibited by E-type prostaglandins but not by PGI2.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cyclic AMP; Diterpenes; Epoprostenol; Free Radicals; Ginkgolides; Glucuronidase; Humans; In Vitro Techniques; Lactones; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Prostaglandins E; Superoxides | 1990 |
Inhibitory effects of MK-886 on arachidonic acid metabolism in human phagocytes.
Topics: Actins; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cell Survival; Chromatography, High Pressure Liquid; Colony-Stimulating Factors; Eosinophils; Humans; In Vitro Techniques; Indoles; Leukotriene Antagonists; Leukotrienes; Neutrophils; Phagocytes; Platelet Activating Factor; Superoxides | 1990 |
ATP and guanine nucleotide dependence of neutrophil activation. Evidence for the involvement of two distinct GTP-binding proteins.
Topics: Adenosine Triphosphate; Alkaloids; Arachidonic Acid; Arachidonic Acids; Cell Membrane Permeability; GTP-Binding Proteins; Guanine Nucleotides; Humans; In Vitro Techniques; Kinetics; Leukotriene B4; Models, Biological; Neutrophils; Oxygen Consumption; Pertussis Toxin; Platelet Activating Factor; Protein Kinase C; Staurosporine; Structure-Activity Relationship; Virulence Factors, Bordetella | 1990 |
Inhibition of leukotriene B4 synthesis in neutrophils from patients with rheumatoid arthritis by a single oral dose of methotrexate.
Topics: Aged; Arachidonic Acid; Arachidonic Acids; Arthritis, Rheumatoid; Calcimycin; Chemotaxis, Leukocyte; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Methotrexate; Middle Aged; Neutrophils; Phospholipases; Platelet Activating Factor | 1990 |
Preventive effect of several drugs against Pseudomonas aeruginosa infection and the toxicity of combined tumor necrosis factor with lipopolysaccharide: relationship between lethality and the arachidonic cascade.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Antibodies; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arachidonic Acid; Arachidonic Acids; Cephamycins; Chromones; Drug Synergism; Drugs, Chinese Herbal; Female; Leukotriene Antagonists; Leukotriene E4; Lipopolysaccharides; Mice; Mice, Inbred Strains; Platelet Activating Factor; Polymyxin B; Pseudomonas Infections; Recombinant Proteins; SRS-A; Tumor Necrosis Factor-alpha | 1990 |
Regulation of platelet-activating factor receptor and PAF receptor-mediated arachidonic acid release by protein kinase C activation in rat Kupffer cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cells, Cultured; Dimethyl Sulfoxide; Down-Regulation; Enzyme Activation; Kinetics; Kupffer Cells; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetradecanoylphorbol Acetate | 1990 |
Leukocyte and platelet function and eicosanoid production in subjects with hypercholesterolaemia.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Collagen; Fatty Acids; Female; Humans; Hyperlipoproteinemia Type II; Leukotriene B4; Lipids; Luminescent Measurements; Male; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Serotonin; Thromboxane B2 | 1990 |
Effects of a fish oil diet on the metabolism of endogenous (n-6) and (n-3) fatty acids in rat neutrophils.
Topics: Acylation; Animals; Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Dietary Fats, Unsaturated; Eicosapentaenoic Acid; Fatty Acids; Fish Oils; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Male; Neutrophils; Phospholipids; Platelet Activating Factor; Rats; Rats, Inbred Strains | 1990 |
Rat platelet arachidonate metabolism in the presence of Ca2+, Sr2+ and Ba2+: studies using intact platelets and semi-purified phospholipase A2.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Barium; Blood Platelets; Calcium; Cytosol; Dose-Response Relationship, Drug; In Vitro Techniques; Ion Channels; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Selenium; Thrombin | 1987 |
High molecular weight dextran sulfate inhibits intracellular Ca2+ release and decreases growth factor-induced increases in intracellular free Ca2+ in Swiss 3T3 fibroblasts.
Topics: Arachidonic Acid; Arachidonic Acids; Arginine Vasopressin; Bradykinin; Calcimycin; Calcium; Cells, Cultured; Dextran Sulfate; Dextrans; Fibroblasts; Guanosine Triphosphate; Halothane; Heparin; Inositol 1,4,5-Trisphosphate; Mitogens; Molecular Weight; Platelet Activating Factor; Receptors, Cell Surface | 1989 |
Significance of lipid mediators in shock states.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Fatty Acids, Unsaturated; In Vitro Techniques; Leukotrienes; Lipid Metabolism; Platelet Activating Factor; Prostaglandins; Shock; Thromboxane B2 | 1989 |
Arachidonic acid release in rabbit neutrophils.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1989 |
IL-1 and related cytokines enhance thrombin-stimulated PGI2 production in cultured endothelial cells without affecting thrombin-stimulated von Willebrand factor secretion or platelet-activating factor biosynthesis.
Topics: Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Chromatography, Thin Layer; Cycloheximide; Drug Synergism; Endothelium, Vascular; Epoprostenol; Histamine; Humans; Interleukin-1; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Thrombin; von Willebrand Factor | 1989 |
Lipid inflammatory mediators in glomerulonephritis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Glomerulonephritis; Humans; Platelet Activating Factor; Thromboxane A2 | 1989 |
Inhibition of [3H]platelet activating factor (PAF) binding by Zn2+: a possible explanation for its specific PAF antiaggregating effects in human platelets.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cations; Humans; In Vitro Techniques; Kinetics; Phosphatidic Acids; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Secretory Rate; Serotonin; Serum Albumin, Bovine; Thrombin; Zinc | 1989 |
The relationship of insulin antibodies, platelet-fixing immune complexes and platelet-associated IgG to in vitro platelet aggregation and thromboxane B2 synthesis in childhood type 1 (insulin-dependent) diabetes mellitus.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Child; Collagen; Diabetes Mellitus, Type 1; Epinephrine; Female; Humans; Immunoglobulin G; Immunoglobulins; In Vitro Techniques; Insulin Antibodies; Male; Platelet Activating Factor; Platelet Aggregation; Reference Values; Thromboxane B2 | 1989 |
Leukotriene D4 and platelet-activating factor-acether antagonists on allergic and arachidonic acid-induced reactions in guinea pig airways.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Guinea Pigs; Hypersensitivity; In Vitro Techniques; Indomethacin; Lung; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Ovalbumin; Platelet Activating Factor; Respiratory System; SRS-A; Trachea | 1989 |
Inhibition of platelet-activating factor biosynthesis via the acetyltransferase by arachidonic and oleic acids in ionophore A23187-stimulated bovine neutrophils.
Topics: Acetates; Acetyltransferases; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cattle; In Vitro Techniques; Kinetics; Neutrophils; Oleic Acid; Oleic Acids; Platelet Activating Factor | 1989 |
Gamma-thrombin-induced phospholipase A2 activation in rabbit platelets: comparison with alpha-thrombin.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Calcium; Cytosol; Edetic Acid; Enzyme Activation; Humans; Kinetics; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rabbits; Structure-Activity Relationship; Thrombin | 1989 |
[Kinetics of the cellular response: the phenomenon of supercooperativity in platelet aggregation].
Topics: Adenosine Diphosphate; Alprostadil; Arachidonic Acid; Arachidonic Acids; Epinephrine; Humans; In Vitro Techniques; Indomethacin; Kinetics; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors | 1989 |
Arachidonic acid evokes inositol phospholipid hydrolysis in astrocytes.
Topics: Animals; Animals, Newborn; Arachidonic Acid; Arachidonic Acids; Astrocytes; Carbachol; Cells, Cultured; Cerebral Cortex; Hydrolysis; Inositol; Inositol Phosphates; Kinetics; Norepinephrine; Platelet Activating Factor; Rats | 1989 |
Reduced sensitivity of human platelets to PAF-acether following ticlopidine intake.
Topics: Adenosine Diphosphate; Administration, Oral; Arachidonic Acid; Arachidonic Acids; Humans; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 1989 |
Effect of the concentration of Ca2+ in the suspending medium on the responses of human and rabbit platelets to aggregating agents.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Collagen; Dose-Response Relationship, Drug; Humans; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thromboxane B2 | 1989 |
Selenium deficiency inhibits prostacyclin release and enhances production of platelet activating factor by human endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Arachidonic Acids; Calcium; Cells, Cultured; Endothelium, Vascular; Epoprostenol; Glutathione Peroxidase; Histamine; Humans; Inositol 1,4,5-Trisphosphate; Platelet Activating Factor; Selenium; Thrombin; Umbilical Veins | 1989 |
Biosynthesis of paf-acether. Paf-acether but not leukotriene C4 production is impaired in cultured macrophages.
Topics: Acetyltransferases; Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Chromatography, High Pressure Liquid; Female; Macrophages; Mice; Mice, Inbred C57BL; Peritoneal Cavity; Platelet Activating Factor; SRS-A; Zymosan | 1989 |
The role of bradykinin on the effect of plasma kallikrein on platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Collagen; Humans; Kallikreins; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin | 1989 |
Does acute experimental pancreatitis affect blood platelet function?
Topics: Acute Disease; Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; beta-Thromboglobulin; Blood Platelets; Dogs; Hemostasis; In Vitro Techniques; Pancreatitis; Platelet Activating Factor; Platelet Aggregation; Platelet Count; Thromboxane B2 | 1989 |
Effects of aristolochic acid on phospholipase A2 activity and arachidonate metabolism of human neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Aristolochic Acids; Calcimycin; Dose-Response Relationship, Drug; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Neutrophils; Phenanthrenes; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor | 1989 |
Stimulation of platelet-activating factor synthesis by a nonmetabolizable bioactive analog of platelet-activating factor and influence of arachidonic acid metabolites.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Acetates; Arachidonic Acid; Arachidonic Acids; Calcimycin; Humans; Hydrolysis; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Neutrophils; Phospholipases A; Platelet Activating Factor | 1989 |
Pharmacological manipulation of inflammation in rabbit hydronephrosis: effects of a combined cyclooxygenase/lipoxygenase inhibitor ethoxyquin, a thromboxane synthase inhibitor RS-5186 and a PAF antagonist L-659,989.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Ethoxyquin; Fatty Acids, Nonesterified; Furans; Hydronephrosis; Inflammation; Kidney; Leukotriene B4; Lipoxygenase Inhibitors; Male; Perfusion; Platelet Activating Factor; Quinolines; Rabbits; Thiophenes; Thromboxane-A Synthase | 1989 |
Enhanced glomerular thromboxane A2 mediates some pathophysiologic effect of platelet-activating factor in rabbit nephrotoxic nephritis: evidence from biochemical measurements and inhibitor trials.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Furans; Glomerulonephritis; Kidney; Kidney Glomerulus; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Prostaglandins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thromboxane A2; Thromboxane-A Synthase | 1989 |
Characterization of arachidonic acid metabolism, superoxide production, and bacterial killing in bovine circulating neutrophils and elicited alveolar neutrophils.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Bactericidal Activity; Cattle; Haemophilus; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Male; Neutrophils; Platelet Activating Factor; Pulmonary Alveoli; Staphylococcus epidermidis; Superoxides | 1989 |
Mechanism of arachidonic acid liberation in platelet-activating factor-stimulated human polymorphonuclear neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Cell Fractionation; Cell Membrane; Humans; Kinetics; Neutrophils; Pertussis Toxin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tritium; Virulence Factors, Bordetella | 1989 |
Effects of PAF and BN 52021 on cardiac function and regional blood flow in conscious rats.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Diterpenes; Dose-Response Relationship, Drug; Ginkgolides; Hemodynamics; Lactones; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Regional Blood Flow; Vascular Resistance | 1989 |
The alkyl-ether phospholipid platelet-activating factor is a stimulator of the hypothalamic-pituitary-adrenal axis in the rat.
Topics: Adrenocorticotropic Hormone; Alprazolam; Animals; Arachidonic Acid; Arachidonic Acids; Central Nervous System; Corticosterone; Corticotropin-Releasing Hormone; Diterpenes; Ginkgolides; Hypothalamo-Hypophyseal System; Hypothalamus; Lactones; Male; Pituitary Gland; Pituitary-Adrenal System; Platelet Activating Factor; Rats; Rats, Inbred Strains; Verapamil | 1989 |
Synergism between chemotactic peptide and platelet-activating factor in stimulating thromboxane B2 and leukotriene B4 biosynthesis in human neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Humans; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Thromboxane B2 | 1989 |
Arachidonic acid-induced mobilization of calcium in human neutrophils: evidence for a multicomponent mechanism of action.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Cholera Toxin; Egtazic Acid; Humans; In Vitro Techniques; Leukotriene B4; Masoprocol; Neutrophils; Pertussis Toxin; Platelet Activating Factor; Virulence Factors, Bordetella | 1989 |
Tumor necrosis factor causes amplification of arachidonic acid metabolism in response to interleukin 1, bradykinin, and other agonists.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bombesin; Bradykinin; Cell Line; Dexamethasone; Dinoprostone; Interleukin-1; Mice; Norepinephrine; Phospholipases A; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Receptors, Cell Surface; Thrombin; Tumor Necrosis Factor-alpha | 1989 |
Modulation of resynthesis of 1-alkyl-2-arachidonyl-glycero-3-phosphocholine and phosphatidylinositols for interception in vivo of free arachidonic acid, lyso-PAF, diacyl-glycerols, and phosphoinositides.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Burns; Diglycerides; Disease Models, Animal; Flavonoids; Ginkgo biloba; Hemostatics; Humans; Lysophosphatidylcholines; Pain; Pain Measurement; Phosphatidylinositols; Plant Extracts; Platelet Activating Factor; Swine | 1989 |
Intracellular platelet-activating factor regulates eicosanoid generation in guinea-pig resident peritoneal macrophages.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Azepines; Calcimycin; Chromatography, High Pressure Liquid; Culture Media; Dinoprostone; Eicosanoids; Guinea Pigs; In Vitro Techniques; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Peritoneal Cavity; Platelet Activating Factor; Superoxides; Triazines; Triazoles | 1989 |
Antagonism to the actions of platelet activating factor by a nonpsychoactive cannabinoid.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cannabinoids; Dronabinol; Edema; Female; Hydroxyeicosatetraenoic Acids; Mice; Naproxen; Platelet Activating Factor; Structure-Activity Relationship | 1989 |
Oligomers of prostaglandin B1 inhibit arachidonic acid mobilization in human neutrophils and endothelial cells.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Leukotriene B4; Macromolecular Substances; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Platelet Activating Factor; Polymers; Prostaglandins; Prostaglandins B; Serum Albumin, Bovine; Structure-Activity Relationship; Umbilical Veins | 1989 |
Receptor-operated calcium channels in human platelets.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Calcium Channels; Collagen; Humans; Manganese; Platelet Activating Factor; Spectrometry, Fluorescence; Thrombin | 1989 |
Platelet aggregation in the Asian elephant is not dependent on thromboxane B2 production.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Elephants; Female; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Verapamil | 1989 |
Suppression of PAF-induced bronchoconstriction in the guinea-pig by oxatomide: mechanism of action.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Blood Cell Count; Blood Platelets; Blood Pressure; Bronchi; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Macrophages; Muscle Contraction; Piperazines; Platelet Activating Factor; Platelet Aggregation; Pulmonary Alveoli; Respiratory Function Tests; Superoxides | 1989 |
Evidence for a role for Na+-H+ exchange in activation of human platelets by PAF.
Topics: Amiloride; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Humans; Hydrazines; Indomethacin; Platelet Activating Factor; Platelet Aggregation; Protons; Serotonin; Sodium; Thromboxane A2; Thromboxane B2 | 1987 |
Potential involvement of vicinal sulfhydryls in stimulus-induced rabbit platelet activation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arsenicals; Blood Platelets; Calcimycin; Cyclic AMP; Molecular Weight; Platelet Activating Factor; Rabbits; Sulfhydryl Reagents; Thrombin | 1987 |
The effects of N-3 polyunsaturated fatty acids on the generation of platelet-activating factor-acether by human monocytes.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Calcimycin; Dietary Fats; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fish Oils; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Platelet Activating Factor | 1987 |
Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels.
Topics: Alprostadil; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Buffers; Collagen; Cyclic AMP; Flavones; Flavonoids; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Aggregation Inhibitors; Radioimmunoassay; Theophylline | 1988 |
Role of lipoxygenase metabolites of arachidonic acid in T cell activation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclic GMP; Humans; Leukotriene B4; Leukotrienes; Lipid Peroxides; Lipoxygenase; Lymphocyte Activation; Mice; Platelet Activating Factor; T-Lymphocytes | 1988 |
Cytosolic calcium, oxygen consumption and the intracellular pH of stimulated neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cell Separation; Concanavalin A; Cytoplasm; Digitonin; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Platelet Activating Factor; Protons; Sodium; Tetradecanoylphorbol Acetate | 1988 |
Interaction between PAF-acether and drugs that stimulate cyclic AMP in guinea-pig alveolar macrophages.
Topics: Albuterol; Animals; Arachidonic Acid; Arachidonic Acids; Cell Adhesion; Cyclic AMP; Dinoprostone; Female; Guinea Pigs; In Vitro Techniques; Macrophages; Male; Platelet Activating Factor; Prostaglandins E; Pulmonary Alveoli | 1988 |
Biosynthesis of platelet-activating factor in glandular gastric mucosa. Evidence for the involvement of the 'de novo' pathway and modulation by fatty acids.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Acetyltransferases; Animals; Arachidonic Acid; Arachidonic Acids; Diacylglycerol Cholinephosphotransferase; Fatty Acids; Gastric Mucosa; In Vitro Techniques; Kinetics; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Phosphoric Diester Hydrolases; Phosphotransferases; Platelet Activating Factor; Rats; Rats, Inbred Strains | 1988 |
Platelet-activating factor stimulates arachidonic acid metabolism in rat liver cells (C-9 cell line) by a receptor-mediated mechanism.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Carcinogens; Cell Line; Liver; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1988 |
Effect of dietary fish oils on the formation of leukotriene B4 and B5, thromboxane and platelet activating factor by rat leukocytes.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Diet; Eicosapentaenoic Acid; Fatty Acids; Fish Oils; In Vitro Techniques; Leukocytes; Leukotriene B4; Lipoxygenase; Male; Phospholipids; Platelet Activating Factor; Rats; Rats, Inbred Strains; Thromboxane B2; Thromboxanes | 1988 |
Paf-acether-induced death in mice: involvement of arachidonate metabolites and beta-adrenoceptors.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Bronchial Spasm; Dexamethasone; Male; Mice; Platelet Activating Factor; Receptors, Adrenergic, beta | 1987 |
Regulation of PAF-acether (platelet-activating factor) biosynthesis in cultured human vascular endothelial cells stimulated with thrombin.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Acetyl-CoA C-Acetyltransferase; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Endothelium, Vascular; Female; Humans; Kinetics; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Thrombin; Umbilical Veins | 1987 |
Synergistic effects of platelet-activating factor and other platelet agonists in human platelet aggregation and release: the role of ADP and products of the cyclooxygenase pathway.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; beta-Thromboglobulin; Blood Platelets; Calcimycin; Collagen; Drug Synergism; Epinephrine; Humans; Kinetics; Platelet Activating Factor; Platelet Aggregation; Ristocetin; Thrombin | 1985 |
Platelet-activating factor: alternate pathways of biosynthesis, mechanism of inactivation, and reacylation of lyso-PAF with arachidonate.
Topics: Acetyltransferases; Animals; Arachidonic Acid; Arachidonic Acids; Choline O-Acetyltransferase; Kidney; Platelet Activating Factor | 1985 |
Endogenous platelet-activating factor and anti-platelet-activating factor in patients with renovascular hypertension.
Topics: Adenosine Diphosphate; Adolescent; Adult; Angioplasty, Balloon; Arachidonic Acid; Arachidonic Acids; Female; Humans; Hypertension, Renovascular; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Renal Veins | 1988 |
Inhibition of phospholipase A2 activity of guinea-pig alveolar macrophages by lipocortin-like proteins purified from mice lung.
Topics: Animals; Annexins; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Glycoproteins; Guinea Pigs; Lung; Macrophages; Mice; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Pulmonary Alveoli | 1988 |
Mechanisms of endothelium-dependent vascular smooth muscle relaxation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cyclic GMP; Cyclooxygenase Inhibitors; Endothelium; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Platelet Activating Factor; Receptors, Muscarinic; Vasoconstriction; Vasodilation; Vasodilator Agents | 1985 |
Leukocytic functions in burn-injured patients.
Topics: Adolescent; Adult; Aged; Arachidonic Acid; Arachidonic Acids; Burns; Calcium; Ceruloplasmin; Chromatography, High Pressure Liquid; Female; Humans; Leukocyte Count; Leukocytes; Male; Middle Aged; Monocytes; Neutrophils; Phagocytosis; Platelet Activating Factor; Potassium; Superoxides; T-Lymphocytes; Time Factors | 1985 |
Platelet-activating factor and leukotriene biosynthesis is inhibited in polymorphonuclear leukocytes depleted of arachidonic acid.
Topics: Acetates; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Dietary Fats; Leukotriene B4; Neutrophils; Oligopeptides; Platelet Activating Factor; Rats | 1986 |
Phospholipase A2 products induce pulmonary beta-adrenoceptor deviations.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dihydroalprenolol; Guinea Pigs; In Vitro Techniques; Inflammation; Lung; Male; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Receptors, Adrenergic, beta | 1986 |
Potentiation of 5-lipoxygenase metabolism by human neutrophils using a combination of activators.
Topics: Arachidonate 5-Lipoxygenase; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Drug Synergism; Humans; Leukotriene B4; Leukotrienes; Neutrophils; Platelet Activating Factor; Stimulation, Chemical | 1986 |
Chemical mediators of anaphylaxis released by alveolar macrophages in bronchial asthma.
Topics: Anaphylaxis; Arachidonic Acid; Arachidonic Acids; Asthma; Blood Proteins; Humans; Leukotriene B4; Macrophages; Platelet Activating Factor; Pulmonary Alveoli | 1986 |
Arachidonate metabolites, platelet-activating factor, and the mobilization of protein kinase C in human polymorphonuclear neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Membrane; Cell-Free System; Cytosol; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Neutrophils; Platelet Activating Factor; Protamine Kinase; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Solubility; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1987 |
Antagonism of vasoconstriction induced by platelet-activating factor in guinea-pig perfused hearts by selective platelet-activating factor receptor antagonists.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Chromones; Coronary Vessels; Diterpenes; Furans; Ginkgolides; Guinea Pigs; In Vitro Techniques; Indomethacin; Lactones; Leukotriene B4; Male; Perfusion; Plant Extracts; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; SRS-A; Thromboxane A2; Time Factors; Vasoconstriction | 1987 |
Effect of platelet-activating factor on arachidonic acid metabolism in renal epithelial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cells, Cultured; Enzyme Activation; Epithelial Cells; Epithelium; Kidney; Lipid Metabolism; Mice; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Prostaglandins; Type C Phospholipases | 1986 |
Platelet-activating factor stimulates prostaglandin synthesis in cultured cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Diglycerides; Hydrolysis; In Vitro Techniques; Kidney; Muscle, Smooth, Vascular; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Prostaglandins; Rats; Time Factors; Type C Phospholipases | 1986 |
A defect of platelet release reaction in a patient with SLE: impaired platelet aggregation induced by phorbol ester with a normal phosphorylation of 40K protein.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Blood Proteins; Calcimycin; Collagen; Diglycerides; Epinephrine; Female; Humans; Lupus Erythematosus, Systemic; Phorbols; Phosphorylation; Platelet Activating Factor; Platelet Aggregation; Tetradecanoylphorbol Acetate; Thrombin | 1986 |
FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Chemical Phenomena; Chemistry; Collagen; Fermentation; Indoles; Piperazines; Platelet Activating Factor; Platelet Aggregation; Rabbits; Streptomyces | 1986 |
Synergistic platelet activation by aggregates of IgG and the phospholipid platelet-activating factor 1-O-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Dose-Response Relationship, Drug; Drug Synergism; Humans; Immunoglobulin G; Kinetics; Macromolecular Substances; Platelet Activating Factor; Platelet Aggregation; Serotonin | 1986 |
Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids.
Topics: Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Dexamethasone; Humans; Immunoglobulin E; Lung; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Prostaglandin Antagonists; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins D; Prostaglandins F; SRS-A; Thromboxane B2 | 1986 |
Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Benzofurans; Benzopyrans; Blood Platelets; Diterpenes; Ginkgolides; Humans; In Vitro Techniques; Lactones; Lignans; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Thiazoles | 1986 |
Ether-linked lysophospholipids initiate insulin secretion. Lysophospholipids may mediate effects of phospholipase A2 activation on hormone release.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Chromium Radioisotopes; Cytoplasmic Granules; Energy Metabolism; Enzyme Activation; Ethers; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Lysophospholipids; Oxidation-Reduction; Phospholipases; Phospholipases A; Phospholipases A2; Phospholipids; Platelet Activating Factor; Rats | 1986 |
A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Choline; Diglycerides; Dogs; Glycerides; Kidney; Palmitic Acid; Palmitic Acids; Phorbols; Phosphates; Phosphatidylcholines; Phosphatidylethanolamines; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1986 |
Platelet aggregating substance from mononuclear leukocytes.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Coagulation Factors; Catechols; Humans; In Vitro Techniques; Masoprocol; Monocytes; Platelet Activating Factor; Platelet Aggregation | 1986 |
Stimulus-aggregation coupling in platelets activated with PAF-acether.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Cytosol; Fibrinogen; Humans; Kinetics; Molecular Weight; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Platelet Activating Factor; Platelet Aggregation; Temperature; Thromboxane B2 | 1986 |
Coronary vasoconstriction in the rat, isolated perfused heart induced by platelet-activating factor is mediated by leukotriene C4.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arginine Vasopressin; Calcimycin; Coronary Vessels; Heart; In Vitro Techniques; Lipoxygenase; Male; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Rats; Rats, Inbred Strains; SRS-A; Time Factors; Vasoconstriction | 1986 |
Changes induced by PAF-acether in diacyl and ether phospholipids from guinea-pig alveolar macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Guinea Pigs; In Vitro Techniques; Macrophages; Male; Phospholipids; Platelet Activating Factor; Pulmonary Alveoli | 1986 |
A cytosolic phospholipase in human neutrophils that hydrolyzes arachidonoyl-containing phosphatidylcholine.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Cytosol; Heparin; Humans; Hydrogen-Ion Concentration; Hydrolysis; Neutrophils; Phosphatidylcholines; Phospholipases; Platelet Activating Factor; Structure-Activity Relationship; Substrate Specificity | 1986 |
Inhibitory effects of a novel platelet activating factor (PAF) antagonist (BN 52021) on antigen-induced prostaglandin and thromboxane formation by the guinea pig lung.
Topics: Anaphylaxis; Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; Diterpenes; Female; Ginkgolides; Guinea Pigs; In Vitro Techniques; Kinetics; Lactones; Lung; Male; Ovalbumin; Plant Extracts; Platelet Activating Factor; Prostaglandins; Prostaglandins E; Thromboxane B2; Thromboxanes | 1986 |
Platelet-activating factor-induced vasoconstriction in rat isolated, perfused hearts: contribution of cyclo-oxygenase and lipoxygenase arachidonic acid metabolites.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Chromones; Coronary Circulation; Diethylcarbamazine; In Vitro Techniques; Indomethacin; Lipoxygenase; Male; Myocardium; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Vasoconstriction | 1986 |
Alkylacetylglycerols versus lyso-PAF as precursors in PAF biosynthesis and the role of arachidonic acid in PAF metabolism.
Topics: Acetyltransferases; Animals; Arachidonic Acid; Arachidonic Acids; Glycerides; In Vitro Techniques; Inflammation; Lipids; Platelet Activating Factor; Rabbits | 1986 |
Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentration.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Pressure; Dexamethasone; Gastric Mucosa; Hematocrit; Male; Necrosis; Platelet Activating Factor; Prednisolone; Pyrazoles; Rats; Rats, Inbred Strains | 1986 |
Metabolism of platelet-activating factor by arachidonic acid-depleted rat polymorphonuclear leukocytes.
Topics: Acylation; Animals; Arachidonic Acid; Arachidonic Acids; Fatty Acids; Kinetics; Neutrophils; Phosphatidylcholines; Platelet Activating Factor; Rats | 1986 |
Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man.
Topics: Adenosine Diphosphate; Adolescent; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Thromboxane B2; Thromboxanes | 1986 |
Arachidonic acid turnover in response to lipopolysaccharide and opsonized zymosan in human monocyte-derived macrophages.
Topics: Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Fatty Acids; Humans; Lipopolysaccharides; Macrophages; Opsonin Proteins; Phosphatidylcholines; Phospholipids; Platelet Activating Factor; Zymosan | 1986 |
Protection by two ginkgolides, BN-52020 and BN-52021, against guinea-pig lung anaphylaxis.
Topics: Anaphylaxis; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Diterpenes; Dose-Response Relationship, Drug; Ginkgolides; Guinea Pigs; Lactones; Lung; Male; Perfusion; Plant Extracts; Platelet Activating Factor; Thromboxane B2 | 1986 |
Inhibitory effects of three new synthetic compounds on human platelet aggregation.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Humans; Kinetics; Platelet Activating Factor; Platelet Aggregation; Structure-Activity Relationship; Thiophenes; Thrombin | 1986 |
Platelet-activating factor (PAF-acether) induces high- and low-affinity binding of fibrinogen to human platelets via independent mechanisms.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Fibrinogen; Humans; Indomethacin; Kinetics; Macromolecular Substances; Platelet Activating Factor; Prostaglandin Endoperoxides; Protein Binding; Thromboxanes | 1986 |
Effect of phorbol 12-myristate 13-acetate (PMA) on agonist-induced arachidonate release and 5-hydroxytryptamine secretion in human platelets. Dependence of effects on agonist type and time of incubation with PMA.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Collagen; Epinephrine; Humans; In Vitro Techniques; Kinetics; Male; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Serotonin; Tetradecanoylphorbol Acetate; Thrombin | 1987 |
PAF-acether-induced synthesis of prostacyclin by human endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Endothelium; Epoprostenol; Humans; Phospholipids; Platelet Activating Factor; Radioimmunoassay; von Willebrand Factor | 1986 |
LG 30435, a new bronchodilator/antiallergic agent, inhibits PAF-acether induced platelet aggregation and bronchoconstriction.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bronchi; Bronchodilator Agents; Collagen; In Vitro Techniques; Male; Phenothiazines; Platelet Activating Factor; Platelet Aggregation; Rabbits | 1986 |
Effects of the lipid peroxidation product 4-hydroxynonenal on the aggregation of human platelets.
Topics: Adenosine Diphosphate; Aldehydes; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Drug Antagonism; Fatty Acids; Glutathione; Humans; In Vitro Techniques; Malondialdehyde; Platelet Activating Factor; Platelet Aggregation; Thrombin | 1987 |
Phorbol ester-induced formation of clastogenic factor from human monocytes.
Topics: Arachidonic Acid; Arachidonic Acids; Chromosome Aberrations; Humans; Leukotrienes; Lipid Metabolism; Lipid Peroxides; Monocytes; Mutagens; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1987 |
Platelet-activating factor stimulation of rabbit platelets is blocked by serine protease inhibitor (chymotryptic protease inhibitor).
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Kinetics; Platelet Activating Factor; Protease Inhibitors; Proteins; Rabbits; Serine Proteinase Inhibitors; Serotonin | 1987 |
Fatty acid composition of diacyl, alkylacyl, and alkenylacyl phospholipids of control and arachidonate-depleted rat polymorphonuclear leukocytes.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Fatty Acids; Male; Neutrophils; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Platelet Activating Factor; Rats; Rats, Inbred Strains | 1987 |
Metabolism of platelet-activating factor in isolated perfused rat lung.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Glycerylphosphorylcholine; Lung; Male; Perfusion; Phosphatidylcholines; Platelet Activating Factor; Rats | 1987 |
Decreased pulmonary vascular responsiveness in rats raised on an essential fatty acid deficient diet.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Body Weight; Dietary Fats; Fatty Acids, Unsaturated; In Vitro Techniques; Lung; Male; Platelet Activating Factor; Rats; Rats, Inbred Strains; SRS-A; Vasoconstriction | 1987 |
Antiplatelet effect of butylidenephthalide.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Blood Coagulation Factors; Calcimycin; Collagen; Dinoprostone; Guinea Pigs; Humans; In Vitro Techniques; Phthalic Acids; Phthalic Anhydrides; Platelet Activating Factor; Platelet Aggregation; Prostaglandins E; Rabbits; Thrombin; Thromboxane B2 | 1987 |
Platelet-activating factor modulates phospholipid acylation in human neutrophils.
Topics: Acylation; Arachidonic Acid; Arachidonic Acids; Calcium; Humans; Neutrophils; Phosphatidylcholines; Phosphatidylinositols; Phospholipids; Platelet Activating Factor | 1987 |
Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Collagen; Diglycerides; Humans; Kinetics; Phorbol 12,13-Dibutyrate; Phorbol Esters; Platelet Activating Factor; Platelet Aggregation; Protein Kinase C; Sphingosine; Thrombin | 1987 |
Vinca alkaloids inhibit conversion of arachidonic acid to thromboxane by human platelet microsomes: comparison with other microtubule-active drugs.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Chromatography, Thin Layer; Cyclooxygenase Inhibitors; Dinoprostone; Humans; In Vitro Techniques; Malondialdehyde; Microsomes; Oxygen Consumption; Platelet Activating Factor; Platelet Aggregation; Prostaglandins E; Thromboxane B2; Vinblastine | 1987 |
Platelet-activating factor induces leukotriene C4 synthesis by purified human eosinophils.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Chromatography, High Pressure Liquid; Drug Synergism; Eosinophils; Humans; Platelet Activating Factor; Radioimmunoassay; SRS-A; Time Factors; Zymosan | 1987 |
Platelet-leukocyte interaction: activation of rabbit platelets by FMLP-stimulated neutrophils.
Topics: Acetylglucosaminidase; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Female; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Rabbits | 1987 |
Platelet-activating factor in the inflammatory exudate in the anaphylactic phase of allergic inflammation in rats.
Topics: Adenosine Diphosphate; Anaphylaxis; Animals; Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Exudates and Transudates; Inflammation; Male; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rats; Rats, Inbred Strains; Thiazoles | 1987 |
Effect of platelet activating factor antagonists on cultured rat mesangial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzofurans; Calcimycin; Cells, Cultured; Dinoprostone; Diterpenes; Dose-Response Relationship, Drug; Ginkgolides; Glomerular Mesangium; Lactones; Lignans; Male; Plant Extracts; Platelet Activating Factor; Prostaglandins E; Rats; Thiazoles | 1987 |
Effect of selected antiinflammatory agents and other drugs on zymosan, arachidonic acid, PAF and carrageenan induced paw edema in the mouse.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Carrageenan; Drug Evaluation, Preclinical; Edema; Female; Mice; Platelet Activating Factor; Zymosan | 1987 |
Ether phospholipids in control and 20:4-depleted rat PMN: additional evidence for a 1-O-alkyl-2-20:4-sn-glycerol-3-phosphocholine specific phospholipase A2.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipid Ethers; Platelet Activating Factor; Rats | 1987 |
Platelet-activating factor (PAF-acether) formation in rat basophilic leukemia cells stimulated by ionophore A23187.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Basophils; Calcimycin; Leukemia, Experimental; Platelet Activating Factor; Quinacrine; Rats | 1987 |
Vasodepressor phospholipids in reversal of renal hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Antihypertensive Agents; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Dinoprostone; Hypertension, Renovascular; Phospholipases A; Phospholipids; Platelet Activating Factor; Prostaglandins E; Rats | 1987 |
Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Dinoprost; Dinoprostone; Glucagon; In Vitro Techniques; Liver; Male; Oxygen Consumption; Phenylephrine; Platelet Activating Factor; Prostaglandin D2; Prostaglandins D; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Thromboxane A2; Vasoconstriction | 1988 |
Parallel inhibition of platelet-activating factor-induced protein phosphorylation and serotonin release by K-252a, a new inhibitor of protein kinases, in rabbit platelets.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Carbazoles; Cytosol; Indole Alkaloids; Male; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Proteins; Rabbits; Serotonin | 1988 |
Antagonism of PAF-induced death in mice.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Diterpenes; Epinephrine; Fatty Acids, Unsaturated; Furans; Ginkgolides; Hydrazines; Lactones; Male; Mice; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Pyridines; Thiazoles; Thromboxane A2 | 1988 |
Arachidonic acid can induce leukotriene C4 formation by purified human eosinophils in the absence of other stimuli.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Calcium Chloride; Eosinophils; Glutathione; Humans; In Vitro Techniques; Masoprocol; Platelet Activating Factor; SRS-A | 1988 |
Platelet-activating factor and the cardiovascular system: involvement in cardiac anaphylaxis.
Topics: Anaphylaxis; Animals; Arachidonic Acid; Arachidonic Acids; Guinea Pigs; Heart; Male; Platelet Activating Factor; Vasoconstriction | 1988 |
The effect of drugs which affect the arachidonate cascade in burned rabbits.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Coagulation; Blood Platelets; Burns; Epoprostenol; Fibrinolysis; Kidney; Methacrylates; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Thromboxane-A Synthase | 1986 |
Why single daily dose of aspirin may not prevent platelet aggregation.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Drug Synergism; Female; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 1988 |
Inhibition of the alkali burn-induced lipoxygenation of arachidonic acid in the rabbit cornea in vivo by a platelet activating factor antagonist.
Topics: Alkalies; Animals; Aqueous Humor; Arachidonic Acid; Arachidonic Acids; Burns, Chemical; Cornea; Diterpenes; Eye Burns; Eye Proteins; Female; Ginkgolides; Hydroxyeicosatetraenoic Acids; Lactones; Lipoxygenase; Male; Membrane Lipids; Phospholipids; Platelet Activating Factor; Rabbits | 1987 |
[Arachidonic acid metabolism and chronic obstructive respiratory tract diseases: pathologic effects and perspectives for therapy].
Topics: Arachidonic Acid; Arachidonic Acids; Bronchi; Humans; Lung Diseases, Obstructive; Phospholipases A; Platelet Activating Factor | 1988 |
Effects of ethanol on pathways of platelet aggregation in vitro.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Collagen; Ethanol; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Rabbits; Thrombin | 1988 |
Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Line; Cytosol; Hydrogen-Ion Concentration; Hydrolysis; Macrophages; Mice; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Structure-Activity Relationship; Substrate Specificity | 1988 |
Human platelet electrorotation change induced by activation: inducer specificity and correlation to serotonin release.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Cell Membrane; Collagen; Cytoplasmic Granules; Electric Conductivity; Electrophysiology; Epinephrine; Humans; Kinetics; Microscopy, Electron; Platelet Activating Factor; Platelet Aggregation; Serotonin; Thrombin | 1988 |
The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Glucose; Glycogen; Indomethacin; Kupffer Cells; Liver; Male; Perfusion; Platelet Activating Factor; Prostaglandin D2; Rats; Rats, Inbred Strains | 1988 |
Esterification of 8,11,14-eicosatrienoate and arachidonate into alkylacyl- and diacylglycerophosphocholine by vascular endothelial cells.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Endothelium, Vascular; Esterification; Fatty Acids, Unsaturated; Humans; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Platelet Activating Factor | 1988 |
Involvement of arachidonate-dependent lipid mediators and platelet-activating factor in experimental murine contact dermatitis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Capillary Permeability; Croton Oil; Dermatitis, Contact; Dinitrofluorobenzene; Ear, External; Female; Lipids; Lipoxygenase Inhibitors; Mice; Mice, Inbred BALB C; Platelet Activating Factor | 1988 |
Acetyl glycerylphosphorylcholine aggregates human platelets through two distinct pathways, both dependent on arachidonic acid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Catechols; Chromatography, Thin Layer; Cyclooxygenase Inhibitors; Humans; Imidazoles; In Vitro Techniques; Lipoxygenase Inhibitors; Masoprocol; Phospholipases; Platelet Activating Factor; Platelet Aggregation; Prostanoic Acids; Quinacrine; Radioimmunoassay; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase | 1985 |
Cyclooxygenase inhibition, platelet function, and metabolite formation during chronic sulfinpyrazone dosing.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cyclooxygenase Inhibitors; Epoprostenol; Humans; Platelet Activating Factor; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Sulfinpyrazone; Thromboxane B2 | 1985 |
Inactivation of platelet activating factor by rabbit platelets. Lyso-platelet activating factor as a key intermediate with phosphatidylcholine as the source of arachidonic acid in its conversion to a tetraenoic acylated product.
Topics: Acetylation; Acylation; Alkylation; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Female; Male; Phosphatidylcholines; Platelet Activating Factor; Rabbits | 1985 |
Effect of C-reactive protein on platelet-activating factor-induced platelet aggregation and membrane stabilization.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; C-Reactive Protein; Cell Membrane; Lysophosphatidylcholines; Phospholipases; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thrombin | 1985 |
CoA-independent transfer of arachidonic acid from 1,2-diacyl-sn-glycero-3-phosphocholine to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso platelet-activating factor) by macrophage microsomes.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Cholic Acid; Cholic Acids; Coenzyme A; Macrophages; Magnesium; Microsomes; Phosphatidylcholines; Platelet Activating Factor; Quinacrine; Rabbits | 1985 |
Desaggregation of PAF-acether-aggregated platelets by verapamil and TMB-8 with reversal of phosphorylation of 40K and 20K proteins.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Egtazic Acid; Gallic Acid; In Vitro Techniques; Lanthanum; Phosphorylation; Platelet Activating Factor; Platelet Aggregation; Proteins; Rabbits; Serotonin; Verapamil | 1985 |
Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Diglycerides; Guinea Pigs; Kinetics; Neutrophils; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Platelet Activating Factor | 1985 |
Lipoxygenase products of arachidonic acid modulate biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human neutrophils via phospholipase A2.
Topics: Acetates; Acetic Acid; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Calcimycin; Catechols; Humans; Hydroxyeicosatetraenoic Acids; Lipoxygenase; Masoprocol; Membrane Lipids; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Trifluoperazine | 1985 |
Possible participation of adenosine 5'-diphosphate, arachidonic acid and paf-acether in the platelet pro-aggregating effect of uncontrolled insulin-dependent diabetic erythrocytes in vitro.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Diabetes Mellitus, Type 1; Erythrocytes; Glutaral; Humans; Plasma; Platelet Activating Factor; Platelet Aggregation | 1985 |
Action mechanism of the platelet aggregation inducer and inhibitor from Echis carinatus snake venom.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Chymotrypsin; Collagen; Fibrinogen; Heparin; Hirudins; Platelet Activating Factor; Platelet Aggregation; Prostaglandins E; Rabbits; Thrombin; Viper Venoms | 1985 |
Effects of platelet-activating factor on the release of arachidonic acid and prostaglandins by rabbit iris smooth muscle. Inhibition by calcium channel antagonists.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Calcium Channel Blockers; Dinoprostone; Dose-Response Relationship, Drug; Female; Iris; Male; Microsomes; Muscle, Smooth; Phosphatidylinositols; Platelet Activating Factor; Prostaglandins; Prostaglandins E; Rabbits; Time Factors | 1985 |
Subcellular localization of vasopressin-like material in platelets.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Arginine Vasopressin; Blood Platelets; Calcimycin; Collagen; Epinephrine; Humans; Microscopy, Electron; Norepinephrine; Platelet Activating Factor; Subcellular Fractions | 1985 |
Identification of platelet inhibitor present in the melon (Cucurbitacea cucumis melo).
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Collagen; Epinephrine; Fruit; Humans; Kinetics; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thrombin | 1985 |
Changing concepts on pathogenesis of asthma.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Asthma; Bronchi; Chemotactic Factors; Child; Epithelium; Humans; Inflammation; Macrophages; Mast Cells; Platelet Activating Factor; Pulmonary Alveoli; Vagus Nerve | 1985 |
Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF).
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Collagen; Diglycerides; Epinephrine; Humans; Oxidation-Reduction; Phosphatidic Acids; Platelet Activating Factor; Platelet Aggregation; Thrombin | 1985 |
Methionine-enkephalin does not alter human platelet aggregatory response.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Collagen; Enkephalin, Methionine; Epinephrine; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Thrombin | 1985 |
[Cell membrane and phospholipids].
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Cell Membrane; Humans; Lysophosphatidylcholines; Membrane Lipids; Phospholipases A; Phospholipases A2; Phospholipids; Platelet Activating Factor; Prostaglandins; SRS-A; Thromboxanes; Type C Phospholipases | 1985 |
Platelet-activating factor-induced aggregation of human platelets specifically inhibited by triazolobenzodiazepines.
Topics: Adenosine Diphosphate; Alprazolam; Anti-Anxiety Agents; Arachidonic Acid; Arachidonic Acids; Benzodiazepines; Blood Platelets; Calcimycin; Chromatography, Gel; Collagen; Epinephrine; Humans; Platelet Activating Factor; Platelet Aggregation; Thrombin; Triazolam | 1984 |
Neutrophil-degranulating action of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid and 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. Comparison with other degranulating agents.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cattle; Chemotactic Factors; Cytochalasin B; Cytoplasmic Granules; Humans; In Vitro Techniques; Leukotriene B4; Lysophosphatidylcholines; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Rabbits; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1981 |
Evidence for mediation of acetyl glyceryl ether phosphorylcholine stimulation of adenosine 3',5'-(cyclic)monophosphate levels in human polymorphonuclear leukocytes by leukotriene B4.
Topics: Adenylyl Cyclases; Animals; Arachidonic Acid; Arachidonic Acids; Cyclic AMP; Enzyme Activation; Epinephrine; Humans; Kinetics; Leukotriene B4; Neutrophils; Platelet Activating Factor; Sodium Fluoride; Swine | 1983 |
CV-3988 - a specific antagonist of platelet activating factor (PAF).
Topics: Adenosine Diphosphate; Alprostadil; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Calcimycin; Collagen; Dose-Response Relationship, Drug; Male; Micelles; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Prostaglandins E; Rabbits; Rats; Rats, Inbred Strains; Thiazoles | 1983 |
Stimulation of calcium uptake by 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in rabbit platelets: possible involvement of the lipoxygenase pathway.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport, Active; Blood Platelets; Calcium; Indomethacin; Platelet Activating Factor; Rabbits; Verapamil | 1983 |
Identification of phospholipid platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid and urine.
Topics: Amniotic Fluid; Arachidonic Acid; Arachidonic Acids; Calcium; Female; Humans; Indomethacin; Platelet Activating Factor; Platelet Aggregation; Pregnancy | 1983 |
1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a novel source of arachidonic acid in neutrophils stimulated by the calcium ionophore A23187.
Topics: Animals; Anti-Bacterial Agents; Arachidonic Acid; Arachidonic Acids; Calcimycin; Chromatography, High Pressure Liquid; Neutrophils; Platelet Activating Factor; Rabbits; Stearic Acids | 1983 |
Selective acylation of lyso platelet activating factor by arachidonate in human neutrophils.
Topics: Acylation; Arachidonic Acid; Arachidonic Acids; Humans; Kinetics; Neutrophils; Platelet Activating Factor; Tritium | 1983 |
Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Humans; Phosphatidylinositols; Phospholipids; Platelet Activating Factor; Platelet Aggregation; Time Factors | 1983 |
Inflammatory mediators released by complement-derived peptides.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Complement C3; Complement C3b; Complement C5; Complement C5a; Complement C5b; Complement System Proteins; Humans; Inflammation; Lysosomes; Oxygen; Peptides; Platelet Activating Factor | 1983 |
1-O-alkyl-linked phosphoglycerides of human platelets: distribution of arachidonate and other acyl residues in the ether-linked and diacyl species.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Fatty Acids; Gas Chromatography-Mass Spectrometry; Humans; Platelet Activating Factor | 1983 |
Effect of platelet-activating factor and serum-treated zymosan on prostaglandin E2 synthesis, arachidonic acid release, and contraction of cultured rat mesangial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Glomerular Mesangium; Phagocytosis; Platelet Activating Factor; Prostaglandins E; Rats; Zymosan | 1984 |
1-O-alkyl-linked glycerophospholipids of human neutrophils: distribution of arachidonate and other acyl residues in the ether-linked and diacyl species.
Topics: Acylation; Arachidonic Acid; Arachidonic Acids; Ethers; Fatty Acids; Gas Chromatography-Mass Spectrometry; Glycerylphosphorylcholine; Humans; Neutrophils; Phosphatidylethanolamines; Phosphatidylinositols; Phosphatidylserines; Platelet Activating Factor; Sphingomyelins | 1984 |
Effect of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine on calcium fluxes by human platelet microsomes.
Topics: Arachidonic Acid; Arachidonic Acids; Biological Transport; Blood Platelets; Calcimycin; Calcium; Dose-Response Relationship, Drug; Humans; Microsomes; Phosphatidic Acids; Platelet Activating Factor | 1984 |
Activation of phospholipase C is dissociated from arachidonate metabolism during platelet shape change induced by thrombin or platelet-activating factor. Epinephrine does not induce phospholipase C activation or platelet shape change.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Enzyme Activation; Epinephrine; Humans; Indomethacin; Kinetics; Phospholipases; Platelet Activating Factor; Platelet Aggregation; Thrombin; Trifluoperazine; Type C Phospholipases | 1984 |
Effects of tris on responses of human and rabbit platelets to aggregating agents.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Calcium; Collagen; Dose-Response Relationship, Drug; Humans; Platelet Activating Factor; Platelet Aggregation; Rabbits; Serotonin; Thrombin; Tromethamine | 1984 |
The platelet-independent release of thromboxane A2 by Paf-acether from guinea-pig lungs involves mechanisms distinct from those for leukotriene.
Topics: Aerosols; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Bradykinin; Female; In Vitro Techniques; Lung; Male; Mice; Muscle Contraction; Muscle, Smooth; Perfusion; Platelet Activating Factor; SRS-A; Thromboxane A2; Thromboxanes | 1984 |
Bronchial anaphylaxis in actively sensitized Sprague Dawley rats: studies on mediators involved.
Topics: Acetylcholine; Anaphylaxis; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Bronchi; Cyclooxygenase Inhibitors; Immunization; Indomethacin; Male; Methysergide; Platelet Activating Factor; Rats; Rats, Inbred Strains; Serotonin; Vagotomy | 1984 |
Platelet-activating factor is a weak platelet agonist: evidence from normal human platelets and platelets with congenital secretion defects.
Topics: Adenosine; Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelet Disorders; Humans; Platelet Activating Factor; Platelet Aggregation; Serotonin; Thrombin; Thromboxanes | 1984 |
1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Chromatography, High Pressure Liquid; Humans; Models, Biological; Neutrophils; Phosphatidylcholines; Phospholipid Ethers; Platelet Activating Factor; Time Factors; Zymosan | 1984 |
Aggregation of bovine platelets by acetyl glyceryl ether phosphorylcholine (platelet activating factor).
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cattle; In Vitro Techniques; Inflammation; Platelet Activating Factor; Platelet Aggregation | 1984 |
Release of arachidonic acid from 1-alkyl-2-acyl-sn-glycero-3-phosphocholine, a precursor of platelet-activating factor, in rat alveolar macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Carbon Radioisotopes; Fatty Acids; Kinetics; Macrophages; Platelet Activating Factor; Rats; Structure-Activity Relationship; Tritium | 1984 |
Platelet-activating factor stimulates phospholipase in quiescent Swiss mouse 3T3 fibroblast.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Choline; Diglycerides; Enzyme Activation; Fibroblasts; Kinetics; Mice; Phospholipases; Phospholipases A; Phospholipases A2; Phospholipids; Platelet Activating Factor; Type C Phospholipases | 1984 |
Metabolism of platelet-activating factor in human platelets. Transacylase-mediated synthesis of 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine.
Topics: Acyltransferases; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Carbon Radioisotopes; Cell Membrane; Humans; Kinetics; Platelet Activating Factor; Tritium | 1984 |
Paf-acether formation and arachidonic acid freeing from platelet ether-linked glyceryl-phosphorylcholine.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Phospholipids; Platelet Activating Factor; Platelet Aggregation; Rabbits; Tritium | 1984 |
The influence of PAF on the metabolization of arachidonic acid by human blood platelets.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Collagen; Humans; Kinetics; Malondialdehyde; Platelet Activating Factor; Platelet Aggregation; Thromboxane B2 | 1984 |
Platelet activating factor. Stimulation of the lipoxygenase pathway in polymorphonuclear leukocytes by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Coagulation Factors; Calcimycin; Cattle; Cytochalasin B; Glucuronidase; Kinetics; Lipoxygenase; Lysophosphatidylcholines; Muramidase; Myocardium; Neutrophils; Platelet Activating Factor; Rabbits | 1982 |
Platelet-activating factor (PAF) as a mediator of neutrophil-platelet interactions in inflammation.
Topics: Arachidonic Acid; Arachidonic Acids; Basophils; Blood Coagulation Factors; Blood Platelets; Humans; Immunoglobulin E; In Vitro Techniques; Inflammation; Lysophosphatidylcholines; Neutrophils; Platelet Activating Factor | 1981 |
Release of platelet-activating factor (PAF-acether) and arachidonic acid metabolites from alveolar macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Humans; In Vitro Techniques; Inflammation; Lysophosphatidylcholines; Macrophages; Papio; Platelet Activating Factor; Pulmonary Alveoli; Rats | 1981 |
Inhibition by sulphinpyrazone of the platelet-dependent bronchoconstriction due to platelet-activating factor (PAF-acether) in the guinea pig.
Topics: Adenosine Diphosphate; Airway Resistance; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Bronchi; Guinea Pigs; In Vitro Techniques; Lysophosphatidylcholines; Muscle Contraction; Platelet Activating Factor; Platelet Count; Sulfinpyrazone | 1982 |
Byssinosis: some unanswered questions.
Topics: Arachidonic Acid; Arachidonic Acids; Byssinosis; Forced Expiratory Volume; Histamine; Humans; Lysophosphatidylcholines; Platelet Activating Factor; SRS-A | 1982 |
Platelet activating factor (PAF) causes human platelet aggregation through the mechanism of membrane modulation.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cell Membrane; Epinephrine; Epoprostenol; Humans; Platelet Activating Factor; Platelet Aggregation; Thromboxane B2; Time Factors | 1982 |
Synergism between platelet activating factor and C-C chemokines for arachidonate release in human monocytes.
Topics: Arachidonic Acid; Chemokine CCL2; Chemokine CCL4; Chemokine CCL5; Chemokine CCL7; Chemotactic Factors; Chemotaxis, Leukocyte; Cytokines; Drug Synergism; Humans; In Vitro Techniques; Kinetics; Lymphokines; Macrophage Inflammatory Proteins; Monocyte Chemoattractant Proteins; Monokines; Platelet Activating Factor | 1994 |
Granulocyte and granulocyte-macrophage colony-stimulating factors exert differential effects on neutrophil platelet-activating factor generation and release.
Topics: Arachidonic Acid; Calcium; Cells, Cultured; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Recombinant Proteins; Respiratory Burst; Superoxides; Tumor Necrosis Factor-alpha | 1994 |
Strain-dependency of leukotriene C4 generation from isolated lungs of immunized mice.
Topics: Animals; Antibodies; Antigens; Arachidonic Acid; Histamine Release; Immunization; Leukotriene C4; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; N-Formylmethionine Leucyl-Phenylalanine; Perfusion; Platelet Activating Factor; Rats; Rats, Wistar; Species Specificity | 1994 |
Inhibition of carrageenin-induced rat paw oedema by crotapotin, a polypeptide complexed with phospholipase A2.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Arachidonic Acid; Carrageenan; Cell Degranulation; Crotoxin; Disease Models, Animal; Edema; Guinea Pigs; Histamine Release; Humans; Injections, Intraperitoneal; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Aggregation; Rats; Rats, Wistar; Serotonin; Thromboxane B2 | 1995 |
Cytoprotective effects of CI-959 in the rat gastric mucosa: modulation of leukocyte adhesion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cell Adhesion; Dinoprostone; Dogs; Ethanol; Female; Gastric Acid; Gastric Mucosa; Histamine Antagonists; Indomethacin; Leukocytes; Leukotriene C4; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sulfhydryl Compounds; Tetrazoles; Thiophenes | 1995 |
SB 203347, an inhibitor of 14 kDa phospholipase A2, alters human neutrophil arachidonic acid release and metabolism and prolongs survival in murine endotoxin shock.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Arachidonic Acid; Cell-Free System; Disease Models, Animal; Enzyme Inhibitors; Humans; Leukotriene B4; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Shock, Septic; Sulfonamides; Survivors | 1995 |
Stimulation of platelet-activating factor synthesis in polymorphonuclear leukocytes from streptozotocin-induced diabetic rats.
Topics: Acetates; Acetyltransferases; Acyltransferases; Animals; Arachidonic Acid; Biological Assay; Diabetes Mellitus, Experimental; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Kinetics; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Rats, Wistar; Reference Values | 1995 |
Leukotriene synthesis in calcium-depleted human neutrophils: arachidonic acid release correlates with calcium influx.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcium; Chromatography, High Pressure Liquid; Enzyme Activation; Humans; In Vitro Techniques; Kinetics; Leukotriene B4; Leukotrienes; Mass Spectrometry; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Platelet Activating Factor | 1995 |
Studies on the mechanism of anti-inflammatory and anti-ulcer activity of Pluchea indica--probable involvement of 5-lipooxygenase pathway.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Ethanol; Gastric Mucosa; Histamine Release; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Plant Extracts; Platelet Activating Factor; Rats | 1993 |
Tumor necrosis factor induces enhanced responses to platelet-activating factor and differentiation in human monocytic Mono Mac 6 cells.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arachidonic Acid; Calcium; Cell Differentiation; Cell Division; Cells, Cultured; Furans; In Vitro Techniques; Lipopolysaccharide Receptors; Lipopolysaccharides; Monocytes; Phagocytosis; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Burst; Superoxides; Tumor Necrosis Factor-alpha | 1993 |
Calphostin C, a specific protein kinase C inhibitor, activates human neutrophils: effect on phospholipase A2 and aggregation.
Topics: Arachidonic Acid; Calcium; Cell Aggregation; Enzyme Activation; Fura-2; Humans; N-Formylmethionine Leucyl-Phenylalanine; Naphthalenes; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Polycyclic Compounds; Protein Kinase C | 1993 |
Increased prostaglandin I2 and thromboxane A2 production by rat dental pulp after intravenous administration of endotoxin.
Topics: Animals; Arachidonic Acid; Azepines; Dental Pulp; Endotoxins; Epoprostenol; Escherichia coli; Indomethacin; Injections, Intravenous; Jejunum; Lung; Male; Platelet Activating Factor; Rats; Rats, Wistar; Thromboxane A2; Time Factors; Triazoles | 1994 |
5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of human eosinophil migration.
Topics: Arachidonic Acid; Arachidonic Acids; Cell Movement; Chemotaxis, Leukocyte; Eosinophils; Glucuronidase; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1995 |
Platelet-activating factor stimulates eicosanoid production in cultured feline tracheal epithelial cells.
Topics: Animals; Arachidonic Acid; Cats; Cells, Cultured; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Eicosanoids; Epithelial Cells; Epithelium; Platelet Activating Factor; Radioimmunoassay; Trachea | 1995 |
Activation of endothelial guanylate cyclase inhibits cellular reactivity.
Topics: Arachidonic Acid; Cell Adhesion; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Guanylate Cyclase; Humans; Molsidomine; Nitric Oxide; Nitroprusside; Oxadiazoles; Platelet Activating Factor; Thrombin; Umbilical Veins | 1995 |
Leukotriene-deficient mice generated by targeted disruption of the 5-lipoxygenase gene.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Bone Marrow Cells; Carrageenan; Dinoprostone; Female; Inflammation; Leukotriene C4; Leukotrienes; Macrophages; Male; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Mutant Strains; Phagocytosis; Phenotype; Platelet Activating Factor; Spleen; Tetradecanoylphorbol Acetate | 1995 |
Antiplatelet actions of 2-(4-[1-(2-chlorophenyl) piperazinyl]) methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one compound.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acid; Blood Platelets; Calcium; Collagen; Cyclic AMP; Epinephrine; Fibrinogen; Humans; Imidazoles; Pancreatic Elastase; Phosphatidylinositols; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Quinazolines; Rabbits; Receptors, Cell Surface; Signal Transduction; Thromboxane A2; Thromboxane B2 | 1995 |
Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells.
Topics: Alkaloids; Analysis of Variance; Animals; Aorta, Thoracic; Arachidonic Acid; Becaplermin; Cell Division; Cells, Cultured; Diacylglycerol Kinase; DNA; Enzyme Activation; Genistein; Humans; Isoflavones; Mitogens; Muscle, Smooth, Vascular; Myristic Acid; Myristic Acids; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Pyrimidinones; Rats; Recombinant Proteins; Signal Transduction; Staurosporine; Thiazoles | 1994 |
Polarized release of lipid mediators derived from phospholipase A2 activity in a human bronchial cell line.
Topics: Arachidonic Acid; Bronchi; Cell Line; Cell Survival; Humans; Melitten; Phospholipases A; Phospholipases A2; Platelet Activating Factor | 1994 |
Effects of organometals on cellular signaling. II. Inhibition of reincorporation of free arachidonic acid and influence on paf-acether synthesis by triethyllead.
Topics: Acetyl-CoA C-Acetyltransferase; Arachidonic Acid; Cell Communication; Cell Differentiation; Humans; Lead; Lysophospholipids; Organometallic Compounds; Platelet Activating Factor; Tumor Cells, Cultured | 1994 |
Comparison of neutrophil chemotactic factor release by human and rabbit alveolar macrophages in response to tannin exposure.
Topics: Animals; Arachidonic Acid; Calcimycin; Cells, Cultured; Chemotaxis, Leukocyte; Culture Media, Conditioned; Humans; Hydrolyzable Tannins; Interleukin-8; Lipoxygenase Inhibitors; Macrophages, Alveolar; Masoprocol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1995 |
The effects of aspirin and paracetamol on the aggregation of equine blood platelets.
Topics: Acetaminophen; Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Cell Size; Collagen; Dose-Response Relationship, Drug; Horses; In Vitro Techniques; Nephelometry and Turbidimetry; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2 | 1994 |
Modulation of glutamate and aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic acid metabolism.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arginine; Aspartic Acid; Female; Flavanones; Flavonoids; gamma-Aminobutyric Acid; Glutamates; Hippocampus; In Vitro Techniques; Indoles; Indomethacin; Masoprocol; omega-N-Methylarginine; Platelet Activating Factor; Potassium; Prostaglandin-Endoperoxide Synthases; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Taurine | 1995 |
Methoctramine induces nonspecific airway hyperresponsiveness in vivo.
Topics: Aerosols; Albuterol; Animals; Arachidonic Acid; Atropine; Bronchial Hyperreactivity; Bronchoconstriction; Diamines; Drug Synergism; Gallamine Triethiodide; Guinea Pigs; Histamine; Male; Muscarinic Antagonists; Ovalbumin; Parasympatholytics; Piperazines; Piperidines; Platelet Activating Factor; Propranolol; Receptors, Muscarinic | 1994 |
Dual inhibition of platelet-activating factor and arachidonic acid metabolism by ajmaline and effect on carrageenan-induced rat paw oedema.
Topics: Ajmaline; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Carbon Radioisotopes; Carrageenan; Edema; Humans; Indomethacin; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Rats; Shock | 1993 |
Endothelial cell-associated platelet-activating factor primes neutrophils for enhanced superoxide production and arachidonic acid release during adhesion to but not transmigration across IL-1 beta-treated endothelial monolayers.
Topics: Arachidonic Acid; Azepines; Cell Adhesion; Cell Movement; Cell Polarity; Endothelium, Vascular; Humans; In Vitro Techniques; Interleukin-1; Neutrophil Activation; Neutrophils; Piperazines; Platelet Activating Factor; Superoxides; Thiazoles; Thiazolidines; Triazoles | 1994 |
Coenzyme A-independent transacylation in amnion-derived (WISH) cells.
Topics: Acylation; Acyltransferases; Amnion; Arachidonic Acid; Cell Line; Coenzyme A; Humans; Lysophosphatidylcholines; Platelet Activating Factor; Substrate Specificity | 1994 |
Inhibitor of phospholipase A2 blocks eicosanoid and platelet activating factor biosynthesis and has topical anti-inflammatory activity.
Topics: Administration, Topical; Anti-Inflammatory Agents; Arachidonic Acid; Dermatitis; Eicosanoids; Humans; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Tretinoin | 1994 |
Arachidonic acid mobilization in P388D1 macrophages is controlled by two distinct Ca(2+)-dependent phospholipase A2 enzymes.
Topics: Animals; Arachidonic Acid; Base Sequence; Cell Line; Dinoprostone; DNA Primers; DNA, Antisense; Gene Expression; Macrophages; Membrane Lipids; Mice; Molecular Sequence Data; Phospholipases A; Phospholipases A2; Phospholipids; Platelet Activating Factor; RNA, Messenger; Time Factors | 1994 |
BIRM 270: a novel inhibitor of arachidonate release that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils.
Topics: Arachidonic Acid; Benzoxazoles; Calcimycin; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor | 1994 |
Autocrine enhancement of leukotriene synthesis by endogenous leukotriene B4 and platelet-activating factor in human neutrophils.
Topics: Amino Acid Sequence; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Complement C5a; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukotriene B4; Leukotrienes; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Platelet Activating Factor; Recombinant Proteins; Signal Transduction; Virulence Factors, Bordetella | 1994 |
Kinetics of 5-lipoxygenase activation, arachidonic acid release, and leukotriene synthesis in human neutrophils: effects of granulocyte-macrophage colony-stimulating factor.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Ionomycin; Kinetics; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Time Factors | 1994 |
Rapid induction of arachidonic acid release by monocyte chemotactic protein-1 and related chemokines. Role of Ca2+ influx, synergism with platelet-activating factor and significance for chemotaxis.
Topics: Arachidonic Acid; Calcimycin; Calcium; Cell Line; Chemokine CCL2; Chemotactic Factors; Chemotaxis, Leukocyte; Cytokines; Egtazic Acid; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Recombinant Proteins; Structure-Activity Relationship; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1994 |
Platelet-activating factor potentiates protamine-induced lung edema. Role of eicosanoids.
Topics: Animals; Arachidonic Acid; Benzoquinones; Constriction, Pathologic; Drug Synergism; Indomethacin; Leukotriene C4; Lipoxygenase Inhibitors; Male; Organ Size; Platelet Activating Factor; Premedication; Prostaglandins F; Protamines; Pulmonary Circulation; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Thromboxane B2; Vascular Resistance | 1994 |
Effects of scalaradial, a type II phospholipase A2 inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Homosteroids; Humans; Leukotrienes; Male; Mice; Mice, Inbred BALB C; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Sesterterpenes; Terpenes; Tetradecanoylphorbol Acetate | 1994 |
Triterpenes and B-sitosterol from piper betle: isolation, antiplatelet and anti-inflammatory effects.
Topics: Adenosine Diphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Areca; Aspirin; Chromatography, Liquid; Edema; Humans; Plants, Medicinal; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Sitosterols; Triterpenes | 1993 |
Effect of a new de-N-acetyl-lysoglycosphingolipid on chemically-induced inflammatory bowel disease: possible mechanism of action.
Topics: Animals; Arachidonic Acid; Carbohydrate Sequence; Colitis; Colon; Gangliosides; Humans; Inflammatory Bowel Diseases; Leukotriene B4; Male; Malondialdehyde; Molecular Sequence Data; Organ Size; Pancreas; Peroxidase; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Spleen; Synovial Fluid; Trinitrobenzenesulfonic Acid | 1993 |
Roles of tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, platelet-activating factor, and arachidonic acid metabolites in interleukin-1-induced resistance to infection in neutropenic mice.
Topics: Animals; Arachidonic Acid; Female; Gram-Negative Bacterial Infections; Granulocyte-Macrophage Colony-Stimulating Factor; Immunoglobulin G; Interleukin-1; Mice; Neutropenia; Platelet Activating Factor; Tumor Necrosis Factor-alpha | 1994 |
Method for simultaneous isolation and quantitation of platelet activating factor and multiple arachidonate metabolites from small samples: analysis of effects of Staphylococcus aureus enterotoxin B in mice.
Topics: Animals; Arachidonic Acid; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Enterotoxins; Hydroxyeicosatetraenoic Acids; Leukotrienes; Male; Mice; Mice, Inbred ICR; Microchemistry; Platelet Activating Factor; Spectrophotometry; Staphylococcus aureus | 1994 |
Inhibition of platelet thromboxane formation and phosphoinositides breakdown by diisoeugenol.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acid; Blood Platelets; Collagen; Cyclic AMP; Eugenol; Humans; Membrane Lipids; Phosphatidylinositols; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thrombin; Thromboxanes | 1994 |
Synthesis and release of platelet-activating factor and eicosanoids in human endothelial cells induced by different agonists.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Blood Platelets; Calcimycin; Cells, Cultured; Dinoprostone; Endothelins; Endothelium, Vascular; Epoprostenol; Histamine; Humans; Hydroxyeicosatetraenoic Acids; Interleukin-1; Platelet Activating Factor; Platelet Aggregation; Prostaglandins; Serotonin; Thrombin; Tumor Necrosis Factor-alpha; Umbilical Veins | 1993 |
Inhibition of collagen-induced platelet aggregation and adhesion by a pseudocyanide derivative of avicine isolated from Zanthoxylum integrifoliolum Merr.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acid; Blood Platelets; Calcium; Cell Adhesion; Collagen; Dioxoles; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Inositol Phosphates; Phenanthridines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandin D2; Proteoglycans; Rabbits; Structure-Activity Relationship; Thromboxane B2 | 1993 |
Dissociation of platelet-activating factor production and arachidonate release by the endomembrane Ca(2+)-ATPase inhibitor thapsigargin. Evidence for the involvement of a Ca(2+)-dependent route of priming in the production of lipid mediators by human poly
Topics: Arachidonic Acid; Calcium; Calcium-Transporting ATPases; Cell Membrane; Glycerophospholipids; Humans; In Vitro Techniques; Ionomycin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Platelet Activating Factor; Terpenes; Thapsigargin | 1993 |
Anti-platelet and anti-thrombotic effects of OP-41483.alpha-CD, a prostacyclin analogue, in experimental animals.
Topics: Adenosine Diphosphate; alpha-Cyclodextrins; Animals; Arachidonic Acid; Blood Coagulation Factors; Blood Platelets; Blood Pressure; Collagen; Cyclodextrins; Dogs; Epoprostenol; Female; Fibrinolytic Agents; Humans; Macaca; Male; Platelet Activating Factor; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Rabbits; Rats; Rats, Wistar; Species Specificity; Thrombocytopenia | 1993 |
Leukotriene B4 and C4 production in isolated rat gastric mucosal cells.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Bucladesine; Calcimycin; Cell Separation; Colforsin; Diglycerides; Female; Gastric Mucosa; Histamine; In Vitro Techniques; Interleukin-1; Interleukin-2; Kinetics; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Pentagastrin; Phenothiazines; Platelet Activating Factor; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1993 |
Transfected platelet-activating factor receptor activates mitogen-activated protein (MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells.
Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Cyclic AMP; Enzyme Activation; GTP-Binding Proteins; Guanosine Triphosphate; Guinea Pigs; Inositol Phosphates; Kinetics; Mitogen-Activated Protein Kinase Kinases; Pertussis Toxin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Transfection; Virulence Factors, Bordetella | 1994 |
Rhazimine from Rhazya stricta: a dual inhibitor of arachidonic acid metabolism and platelet activating factor-induced platelet aggregation.
Topics: Arachidonic Acid; Humans; In Vitro Techniques; Molecular Structure; Pakistan; Plants, Medicinal; Platelet Activating Factor; Platelet Aggregation Inhibitors; Quinolines | 1993 |
Aggregation of killer whale platelets.
Topics: Adaptation, Physiological; Adenosine Diphosphate; Animals; Arachidonic Acid; Blood Platelets; Calcimycin; Collagen; Dolphins; Epinephrine; Female; Male; Platelet Activating Factor; Platelet Aggregation; Ristocetin; Thromboxane B2; Time Factors | 1993 |
Platelet activating factor, lyso-platelet activating factor and arachidonic acid release in normal human skin and the influence of topical steroid treatment.
Topics: Administration, Topical; Adrenal Cortex Hormones; Adult; Arachidonic Acid; Blister; Clobetasol; Dinoprostone; Exudates and Transudates; Female; Gas Chromatography-Mass Spectrometry; Humans; Lipid Metabolism; Male; Middle Aged; Platelet Activating Factor; Skin | 1993 |
Whole blood platelet aggregation in moderate and severe pre-eclampsia.
Topics: Adenosine Diphosphate; Arachidonic Acid; Collagen; Epinephrine; Female; Humans; Platelet Activating Factor; Platelet Aggregation; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Third | 1993 |
Metabolism of arachidonic acid by caruncular and allantochorionic tissues in cows with retained fetal membranes (RFM).
Topics: 6-Ketoprostaglandin F1 alpha; Allantois; Animals; Arachidonic Acid; Calcium; Cattle; Chorion; Chromatography, High Pressure Liquid; Dinoprost; Dinoprostone; Epidermal Growth Factor; Female; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Oxytocin; Placenta; Placenta Diseases; Platelet Activating Factor; Pregnancy; Thromboxane B2 | 1993 |
Mode of action of the new selective leukotriene synthesis inhibitor BAY X 1005 ((R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid) and structurally related compounds.
Topics: Animals; Arachidonic Acid; Binding Sites; Binding, Competitive; Cell-Free System; Humans; Hydroxyeicosatetraenoic Acids; Indoles; Kinetics; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Platelet Activating Factor; Quinolines; Rats; Structure-Activity Relationship; Subcellular Fractions | 1993 |
Stimulatory and inhibitory guanine-nucleotide-binding regulatory protein involvement in stimulation of arachidonic-acid release by N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor from guinea-pig alveolar macrophages. Differential re
Topics: Adenosine Diphosphate Ribose; Animals; Arachidonic Acid; Cell Membrane Permeability; Cells, Cultured; Cholera Toxin; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; Guanine Nucleotides; Guinea Pigs; Macrophages, Alveolar; Magnesium; Male; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Receptors, Cell Surface; Virulence Factors, Bordetella | 1993 |
Differential regulation of early phase and late phase responses in human neutrophils by cAMP.
Topics: Adenylyl Cyclases; Arachidonic Acid; Cell Movement; Cell Size; Chemotaxis; Colforsin; Cyclic AMP; Humans; Interleukin-8; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Superoxides; Time Factors | 1993 |
1,3-Dioctanoylglycerol modulates arachidonate mobilization in human neutrophils and its inhibition by PGBx: evidence of a protein-kinase-C-independent role for diacylglycerols in signal transduction.
Topics: Arachidonic Acid; Calcimycin; Diglycerides; Dose-Response Relationship, Drug; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Polymers; Prostaglandins B; Protein Kinase C; Signal Transduction; Superoxides | 1993 |
Influence of arachidonic acid on indices of phospholipase A2 activity in the human neutrophil.
Topics: Arachidonic Acid; Calcimycin; Fatty Acids; Fatty Acids, Nonesterified; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Leukotrienes; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor | 1993 |
Impaired superoxide anion, platelet-activating factor, and leukotriene B4 synthesis by neutrophils in cirrhosis.
Topics: Adult; Aged; Arachidonic Acid; Calcimycin; Female; Humans; Leukotriene B4; Liver Cirrhosis; Male; Mass Spectrometry; Middle Aged; Neutrophils; Platelet Activating Factor; Superoxides; Zymosan | 1993 |
PAF and thrombin actions in platelets are selectively affected by a new 1,4-dihydropyridine derivative.
Topics: Animals; Arachidonic Acid; Blood Platelets; Diglycerides; Dihydropyridines; Phosphatidylinositols; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thrombin; Type C Phospholipases | 1993 |
Prostaglandin E2 limits arachidonic acid availability and inhibits leukotriene B4 synthesis in rat alveolar macrophages by a nonphospholipase A2 mechanism.
Topics: Animals; Arachidonic Acid; Calcimycin; Dinoprostone; Leukotriene B4; Leukotrienes; Macrophages, Alveolar; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats | 1993 |
Antiplatelet activity of some prenylflavonoids.
Topics: Animals; Arachidonic Acid; Blood Platelets; Collagen; Flavonoids; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Structure-Activity Relationship | 1993 |
Competitive inhibition of phospholipase A2 activity by the platelet-activating factor antagonist Ro 19-3704 and evidence for a novel suppressive effect on platelet activation.
Topics: Animals; Arachidonic Acid; Blood Platelets; Glyceryl Ethers; Male; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Activation; Rabbits; Serum Albumin, Bovine; Thiazoles | 1993 |
Utilization by human amniocytes for prostaglandin synthesis of [1-14C]arachidonate derived from 2-[1-14C]arachidonylphosphatidylcholine associated with human fetal pulmonary surfactant.
Topics: Amnion; Amniotic Fluid; Arachidonic Acid; Carbon Radioisotopes; Fatty Acids; Fetus; Humans; Liposomes; Phosphatidylcholines; Phospholipases; Phospholipids; Platelet Activating Factor; Prostaglandins; Pulmonary Surfactants | 1993 |
Effect of docosahexaenoic acid on the generation of platelet-activating factor by eosinophilic leukemia cells, Eol-1.
Topics: Acetyltransferases; Arachidonic Acid; Calcimycin; Docosahexaenoic Acids; Eosinophils; Fatty Acids, Nonesterified; Humans; Interferon-gamma; Leukemia, Eosinophilic, Acute; Phosphatidylcholines; Phosphatidylethanolamines; Platelet Activating Factor; Tumor Cells, Cultured | 1993 |
The differential effect of aspirin on human platelet activation in aspirin-sensitive asthmatics and normal subjects.
Topics: Adenosine Triphosphate; Adult; Analysis of Variance; Arachidonic Acid; Aspirin; Asthma; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Humans; In Vitro Techniques; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Regression Analysis | 1993 |
Tumor necrosis factor-alpha potentiates phospholipase A2-stimulated release and metabolism of arachidonic acid in cultured intestinal epithelial cells (INT 407).
Topics: Arachidonic Acid; Calcimycin; Cell Line; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Epithelium; Humans; Intestinal Mucosa; Lipid Metabolism; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Type C Phospholipases | 1993 |
Stimulation of platelet-activating factor synthesis by progesterone and A23187 in human spermatozoa.
Topics: Acetyltransferases; Animals; Arachidonic Acid; Calcimycin; Cells, Cultured; Humans; In Vitro Techniques; Male; Platelet Activating Factor; Progesterone; Rabbits; Spermatozoa | 1993 |
Platelet-activating factor preferentially stimulates the phospholipase A2/cyclooxygenase cascade in the rabbit cornea.
Topics: Animals; Arachidonic Acid; Azepines; Cornea; Dinoprostone; Female; In Vitro Techniques; Male; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rabbits; Thienopyridines; Triazoles | 1995 |
Activation of phospholipase A2 and acylation of lysophospholipids: the major regulators for platelet activating factor production in rat neutrophils.
Topics: Acylation; Animals; Antibodies, Monoclonal; Arachidonic Acid; Enzyme Activation; Lysophospholipids; Male; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Thimerosal; Triazenes; Zymosan | 1995 |
Synthesis and antiplatelet effects of omega-aminoalkoxylxanthones.
Topics: Animals; Arachidonic Acid; Collagen; Female; Humans; In Vitro Techniques; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Wistar; Spectrophotometry, Infrared; Structure-Activity Relationship; Thrombin; Xanthenes | 1995 |
Pyrido[2,3-d]pyrimidin-4(3H)-one derivatives and 1,2,3,4-tetrahydro- pyrido[2,3-d]pyrimidine derivatives: synthesis and in vitro study of their activity against platelet aggregation.
Topics: Arachidonic Acid; Collagen; Diterpenes; Fibrinolytic Agents; Ginkgolides; Humans; In Vitro Techniques; Lactones; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrimidines; Pyrimidinones; Serotonin; Spectrophotometry, Infrared | 1995 |
Lipid changes in HL-60 cells on differentiation into macrophages by treatment with a phorbol ester.
Topics: Arachidonic Acid; Carcinogens; Cell Differentiation; Cholesterol; Ethanolamines; HL-60 Cells; Humans; Lipid Metabolism; Macrophages; Phospholipids; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Triglycerides; Tumor Cells, Cultured | 1995 |
Inhibition of the production of platelet activating factor and of leukotriene B4 in activated neutrophils by nimesulide due to an elevation of intracellular cyclic adenosine monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytochalasin B; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoquinolines; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphodiesterase Inhibitors; Platelet Activating Factor; Protein Kinase Inhibitors; Sulfonamides; Zymosan | 1995 |
Interaction of platelet-activating factor with rat hepatocytes: uptake, translocation, metabolism, and effects on PAF-acetylhydrolase secretion and protein tyrosine phosphorylation.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Arachidonic Acid; Biological Transport; Biotransformation; Blotting, Northern; Cells, Cultured; DNA, Complementary; Kinetics; Liver; Male; Phospholipases A; Phospholipases A2; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; RNA, Messenger; Tritium | 1996 |
Enhancement by cyclo-oxygenase inhibitors of platelet-activating factor production in thapsigargin-stimulated macrophages.
Topics: Animals; Arachidonic Acid; Bucladesine; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Ibuprofen; Indomethacin; Macrophages, Peritoneal; Male; Naproxen; Platelet Activating Factor; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Terpenes; Thapsigargin | 1995 |
Predominant expression of platelet-activating factor receptor in the rat brain microglia.
Topics: Animals; Arachidonic Acid; Base Sequence; Blotting, Northern; Brain Chemistry; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; In Situ Hybridization; Male; Microglia; Molecular Sequence Data; Phospholipases A; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger | 1996 |
KW-4679, an antiallergic drug, inhibits the production of inflammatory lipids in human polymorphonuclear leukocytes and guinea pig eosinophils.
Topics: Acetyltransferases; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Autacoids; Dibenzoxepins; Enzyme Activation; Eosinophils; Guinea Pigs; Humans; Leukotriene B4; Lipids; Lipoxygenase Inhibitors; Male; Neutrophils; Olopatadine Hydrochloride; Platelet Activating Factor; Thromboxane B2; Thromboxane-A Synthase | 1996 |
Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum.
Topics: Alkaloids; Animals; Arachidonic Acid; Collagen; Plants, Medicinal; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinazolines; Rabbits; Taiwan; Thrombin | 1996 |
Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophils.
Topics: Acylation; Acyltransferases; Arachidonic Acid; Cell Membrane Permeability; Glycerophosphates; Humans; Lysophospholipids; Membrane Lipids; Neutrophils; Phosphatidylethanolamines; Platelet Activating Factor; Substrate Specificity | 1996 |
Platelet-activating factor and arachidonic acid metabolites in psoriatic inflammation.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adolescent; Adult; Aged; Arachidonic Acid; Child; Dinoprostone; Female; Humans; Leukotrienes; Male; Middle Aged; Phospholipases A; Platelet Activating Factor; Psoriasis; Thromboxane B2 | 1996 |
Inhibitory effect of arachidonic acid on platelet-activating factor production in rat neutrophils.
Topics: Acetyl-CoA C-Acetyltransferase; Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indomethacin; Male; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazenes; Zymosan | 1996 |
Differential expression of platelet activation markers in aspirin-sensitive asthmatics and normal subjects.
Topics: Adult; Antigens, CD; Arachidonic Acid; Aspirin; Asthma; Blood Platelets; Cell Adhesion Molecules; Collagen; Drug Hypersensitivity; Drug Interactions; Female; Flow Cytometry; Humans; Male; Middle Aged; P-Selectin; Platelet Activating Factor; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Tetraspanin 30 | 1996 |
Tumor necrosis factor-alpha, platelet-activating factor, and hydrogen peroxide activate protein kinase C subtypes alpha and epsilon in human saphenous vein endothelial cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acid; Blotting, Western; Endothelium, Vascular; Enzyme Activation; Humans; Hydrogen Peroxide; In Vitro Techniques; Isoenzymes; Platelet Activating Factor; Protein Kinase C; Saphenous Vein; Tumor Necrosis Factor-alpha | 1996 |
Effect of lipoxygenase inhibition on mucous glycoprotein secretion from chinchilla middle ear epithelial cells in vitro.
Topics: Acetamides; Animals; Arachidonic Acid; Cells, Cultured; Chinchilla; Cyclooxygenase Inhibitors; Ear, Middle; Epithelium; Glycoproteins; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Phenyl Ethers; Platelet Activating Factor | 1996 |
Effect of lipopolysaccharide on mitogen-activated protein kinases and cytosolic phospholipase A2.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Genistein; Humans; Immunoblotting; Isoflavones; Lipopolysaccharides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Weight; Myelin Basic Protein; Neutrophils; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein-Tyrosine Kinases; Tyrosine | 1995 |
High-density lipoprotein inhibits the synthesis of platelet-activating factor in human vascular endothelial cells.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Acetyltransferases; Arachidonic Acid; Calcimycin; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Histamine; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Phospholipases A; Platelet Activating Factor; Thrombin; Umbilical Veins | 1996 |
Induction of cytosolic phospholipase A2 activity by phosphatidic acid and diglycerides in permeabilized human neutrophils: interrelationship between phospholipases D and A2.
Topics: Arachidonic Acid; Bacterial Toxins; Cell Membrane Permeability; Cytosol; Diglycerides; Dose-Response Relationship, Drug; Enzyme Induction; Ethanol; Hemolysin Proteins; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Phospholipase D; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Tumor Necrosis Factor-alpha | 1997 |
Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses.
Topics: 5-Lipoxygenase-Activating Proteins; Anaphylaxis; Animals; Arachidonic Acid; Carrier Proteins; DNA, Complementary; Edema; Eicosanoids; Hypersensitivity, Delayed; Immunoglobulin E; Inflammation; Macrophages, Peritoneal; Membrane Proteins; Mice; Mice, Knockout; Peritonitis; Peroxidase; Platelet Activating Factor; RNA, Messenger; Transcription, Genetic; Zymosan | 1997 |
CD16 cross-linking induces both secretory and extracellular signal-regulated kinase (ERK)-dependent cytosolic phospholipase A2 (PLA2) activity in human natural killer cells: involvement of ERK, but not PLA2, in CD16-triggered granule exocytosis.
Topics: Antibodies, Monoclonal; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cytoplasmic Granules; Cytosol; Enzyme Activation; Enzyme Induction; Exocytosis; Humans; Killer Cells, Natural; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Receptors, IgG | 1997 |
Inhibitors of arachidonate metabolism and effects on PAF production.
Topics: Acyltransferases; Animals; Arachidonic Acid; Benzenesulfonates; Bone Marrow; Bone Marrow Cells; Enzyme Inhibitors; Humans; Imidazoles; Mast Cells; Mice; Mice, Inbred CBA; Monocytes; Organophosphorus Compounds; Platelet Activating Factor; Urea | 1996 |
2',5'-Dihydroxychalcone as a potent chemical mediator and cyclooxygenase inhibitor.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Chalcone; Chalcones; Cyclooxygenase Inhibitors; Indomethacin; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Structure-Activity Relationship; Thrombin | 1997 |
Regulation of platelet-activating factor (PAF) biosynthesis via coenzyme A-independent transacylase in the macrophage cell line IC-21 stimulated with lipopolysaccharide.
Topics: Acetyltransferases; Acyltransferases; Animals; Arachidonic Acid; Cell Line; Culture Media; Enzyme Activation; Kinetics; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Platelet Activating Factor | 1997 |
Evidence that 85 kDa phospholipase A2 is not linked to CoA-independent transacylase-mediated production of platelet-activating factor in human monocytes.
Topics: Acyltransferases; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Benzenesulfonates; Calcimycin; Enzyme Inhibitors; Homosteroids; Humans; Monocytes; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Recombinant Proteins; Sesterterpenes; Sulfonamides; Terpenes; Urea | 1997 |
Identification of sn-2 acetyl glycerophosphocholines in human keratinocytes.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Arachidonic Acid; Calcimycin; Cell Line; Dexamethasone; Humans; Infant, Newborn; Ionophores; Keratinocytes; Kinetics; Mass Spectrometry; Platelet Activating Factor | 1997 |
Inflammatory activation of arachidonic acid signaling in murine P388D1 macrophages via sphingomyelin synthesis.
Topics: Animals; Arachidonic Acid; Carboxylic Acids; Diglycerides; Fumonisins; Leukemia P388; Lipopolysaccharides; Macrophages; Mice; Platelet Activating Factor; Sphingomyelins; Tumor Cells, Cultured | 1997 |
Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aporphines; Arachidonic Acid; Blood Platelets; Collagen; Cyclic AMP; Guaiacol; Humans; Isoquinolines; Isotope Labeling; Lipoxygenase Inhibitors; Male; Phenanthrenes; Platelet Activating Factor; Platelet Aggregation Inhibitors; Quinolines; Rabbits; Radioimmunoassay; Structure-Activity Relationship; Thrombin; Thromboxane B2; Vasoconstrictor Agents | 1997 |
The regulation by phosphorylation of 'priming' of phospholipase A2 activity in the neutrophil model system, differentiated HL60 cells.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Differentiation; Cell Membrane; Cytochalasin B; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; HL-60 Cells; Humans; Lysophospholipids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein-Tyrosine Kinases; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1997 |
Diversity of agonist-mediated signal transduction pathways in human platelets.
Topics: Adenosine Diphosphate; Androstadienes; Arachidonic Acid; Blood Platelets; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Epinephrine; Humans; Phosphoinositide-3 Kinase Inhibitors; Platelet Activating Factor; Platelet Aggregation; Serotonin; Signal Transduction; Wortmannin | 1997 |
Anti-thrombotic and anti-inflammatory activities of protopine.
Topics: Adenosine Diphosphate; Alkaloids; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Benzophenanthridines; Berberine Alkaloids; Blood Platelets; Carrageenan; Edema; Fibrinolytic Agents; Histamine H1 Antagonists; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rabbits; Rats; Rats, Sprague-Dawley; Thromboxane A2 | 1997 |
Pulmonary and neutrophil responses to priming effects of platelet-activating factor in pigs.
Topics: Analysis of Variance; Animals; Arachidonic Acid; Blood Gas Analysis; Blood Pressure; Carcinogens; Cyclooxygenase Inhibitors; Indomethacin; Lipopolysaccharides; Neutrophils; Platelet Activating Factor; Random Allocation; Respiratory Physiological Phenomena; Respiratory System; Superoxides; Swine; Tetradecanoylphorbol Acetate; Time Factors; Vascular Resistance | 1997 |
Endotoxin-induced macrophage gene expression depends on platelet-activating factor.
Topics: Animals; Arachidonic Acid; Endotoxins; Escherichia coli; Gene Expression; Macrophages, Alveolar; Male; Platelet Activating Factor; Rabbits; RNA, Messenger; Tumor Necrosis Factor-alpha | 1997 |
Lipid mediators modulate NMDA receptor currents in a Xenopus oocyte expression system.
Topics: Animals; Arachidonic Acid; Lipids; Lysophospholipids; Mice; Oleic Acid; Oocytes; Phosphorylation; Platelet Activating Factor; Protein Kinase Inhibitors; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Xenopus laevis | 1997 |
Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils.
Topics: Arachidonic Acid; Calcium; Catalase; Eicosanoids; Enzyme Inhibitors; Eosinophils; Female; Humans; Indoles; Leukotriene C4; Male; Maleimides; Naphthalenes; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Protein Kinase C; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1998 |
Role of phosphatidylinositol 3-kinase in human platelet aggregation.
Topics: Androstadienes; Arachidonic Acid; Collagen; Enzyme Inhibitors; Epinephrine; Humans; In Vitro Techniques; Kinetics; Phosphatidylinositol 3-Kinases; Platelet Activating Factor; Platelet Aggregation; Serotonin; Wortmannin | 1997 |
Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells.
Topics: Animals; Arachidonic Acid; Cell Membrane; Cloning, Molecular; Cytosol; Diffusion; Diglycerides; Green Fluorescent Proteins; Isoenzymes; Luminescent Proteins; Nuclear Envelope; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, IgE; Recombinant Fusion Proteins; Second Messenger Systems; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1998 |
Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo.
Topics: Animals; Arachidonic Acid; Endothelin-1; Heart; Lipids; Lung; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Swine; Thromboxane B2; Tumor Necrosis Factor-alpha | 1998 |
Nitric oxide mediates platelet-activating factor stimulatory action on uterine prostaglandin production.
Topics: Animals; Arachidonic Acid; Citrulline; Cyclooxygenase Inhibitors; Dinoprostone; Embryo Implantation; Enzyme Inhibitors; Female; Gestational Age; Indomethacin; Isometric Contraction; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Platelet Activating Factor; Pregnancy; Prostaglandins; Rats; Rats, Wistar; Uterus | 1998 |
Agonist-induced sequestration, recycling, and resensitization of platelet-activating factor receptor. Role of cytoplasmic tail phosphorylation in each process.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Cell Membrane; CHO Cells; Clathrin; Cricetinae; Folic Acid; Guinea Pigs; Inositol 1,4,5-Trisphosphate; Models, Molecular; Oligopeptides; Peptides; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Biosynthesis; Protein Structure, Secondary; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Transfection | 1998 |
Effect of GM-CSF on leukotriene B4 synthesis in human neutrophils: facilitation of the priming effect by autologous plasma.
Topics: Arachidonic Acid; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Kinetics; Leukotriene B4; Neutrophils; Plasma; Platelet Activating Factor | 1997 |
Activation of the epidermal platelet-activating factor receptor results in cytokine and cyclooxygenase-2 biosynthesis.
Topics: Arachidonic Acid; Cell Line; Cyclooxygenase 2; Cytokines; Dinoprostone; Epidermis; Humans; Interleukin-6; Interleukin-8; Isoenzymes; KB Cells; Keratinocytes; Membrane Proteins; Models, Biological; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prostaglandin-Endoperoxide Synthases; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1998 |
Anti-platelet aggregation constituents from Formosan Toddalia asiatica.
Topics: Adenosine Diphosphate; Alkaloids; Arachidonic Acid; Benzoquinones; Blood Platelets; Collagen; Coumarins; Humans; Molecular Structure; Plant Extracts; Plant Stems; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Taiwan; Thrombin | 1998 |
Anandamide synthesis is induced by arachidonate mobilizing agonists in cells of the immune system.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Line; Dronabinol; Endocannabinoids; Immune System; Indomethacin; Ionophores; Lipopolysaccharides; Macrophages; Mice; Platelet Activating Factor; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug | 1998 |
Effects of chroman derivatives on platelet aggregation induced by some aggregating agents in rabbits.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Chromans; Collagen; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Structure-Activity Relationship | 1998 |
Effects of suramin on human platelet aggregation and Ca2+ mobilization induced by thrombin and other agonists.
Topics: Antineoplastic Agents; Arachidonic Acid; Blood Platelets; Calcium; Dose-Response Relationship, Drug; Drug Antagonism; Humans; Phosphatidic Acids; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Signal Transduction; Suramin; Thrombin | 1998 |
Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils.
Topics: Acyltransferases; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Flavonoids; Humans; Imidazoles; Lipopolysaccharides; Microsomes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Pyridines; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Types of purinoceptors and phospholipase A2 involved in the activation of the platelet-activating factor-dependent transacetylase activity and arachidonate release by ATP in endothelial cells.
Topics: Acetylesterase; Adenosine Triphosphate; Animals; Arachidonic Acid; Cattle; Cell Line; Dose-Response Relationship, Drug; Endothelium, Vascular; Lysophospholipids; Oligonucleotides; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Receptors, Purinergic; Thionucleotides; Transfection; Uridine Triphosphate | 1998 |
Bacterial lipopolysaccharide induction of the prostaglandin G/H synthase 2 gene causes thromboxane-dependent pulmonary hypertension in rabbits.
Topics: Animals; Arachidonic Acid; Cycloheximide; Cyclooxygenase 1; Cyclooxygenase 2; Dactinomycin; Drug Interactions; Enzyme Induction; Female; Hypertension, Pulmonary; In Vitro Techniques; Isoenzymes; Lipopolysaccharides; Perfusion; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rabbits; Thromboxanes | 1999 |
Effect of DP-1904, a thromboxane synthetase inhibitor, on antigen- and spasmogen-induced bronchoconstriction in rodents.
Topics: Acetylcholine; Animals; Antigens; Arachidonic Acid; Bradykinin; Bronchoconstriction; Bronchoconstrictor Agents; Enzyme Inhibitors; Guinea Pigs; Histamine; Histamine H1 Antagonists; Imidazoles; Indomethacin; Leukotriene D4; Male; Methacrylates; Platelet Activating Factor; Pyrilamine; Rats; Rats, Sprague-Dawley; Tetrahydronaphthalenes; Thromboxane-A Synthase | 1999 |
Inhibitory effect of sulfur-containing compounds in Scorodocarpus borneensis Becc. on the aggregation of rabbit platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Coagulation Factors; Collagen; Hemostatics; Hexanes; Inhibitory Concentration 50; Octanes; Plant Extracts; Plants, Edible; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Sulfur Compounds; Thrombin; Trees; Vasoconstrictor Agents | 1999 |
Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation.
Topics: Adult; Arachidonic Acid; Chromatography, High Pressure Liquid; Diterpenes; Drugs, Chinese Herbal; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Spectrophotometry, Ultraviolet | 1999 |
Effect of the crude extract of Cestrum parqui on carrageenin-induced rat paw oedema and aggregation of human blood platelets.
Topics: Adenosine Diphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrageenan; Edema; Male; Pakistan; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Solanaceae | 1999 |
Effect of protopine on cytosolic Ca2+ in rabbit platelets.
Topics: Adenosine Diphosphate; Alkaloids; Animals; Arachidonic Acid; Benzophenanthridines; Berberine Alkaloids; Biological Transport, Active; Blood Platelets; Calcium; Female; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits | 1999 |
Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcium; Curcuma; Curcumin; Cyclooxygenase Inhibitors; Drug Interactions; Humans; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Signal Transduction; Spices; Thromboxanes | 1999 |
Platelet-activating factor and arachidonic acid metabolites mediate tumor necrosis factor and eicosanoid kinetics and cardiopulmonary dysfunction during bacteremic shock.
Topics: Aeromonas hydrophila; Animals; Arachidonic Acid; Azepines; Bridged Bicyclo Compounds, Heterocyclic; Eicosanoids; Female; Gram-Negative Bacterial Infections; Heart Diseases; Hemodynamics; Hypertension, Pulmonary; Lipoxygenase Inhibitors; Masoprocol; Oxazoles; Oxygen; Oxygen Consumption; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Shock, Septic; Swine; Thromboxane A2; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice.
Topics: Acute Disease; Anaphylaxis; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell Movement; Crosses, Genetic; Cysteine; Dermatitis, Contact; Ear; Epoxide Hydrolases; Fluorescein-5-isothiocyanate; Immunoglobulin E; Inflammation Mediators; Leukotriene B4; Leukotrienes; Lipopolysaccharides; Mice; Mice, Knockout; Neutrophils; Peritonitis; Platelet Activating Factor | 1999 |
PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in the isolated rabbit lung.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Capillaries; Cysteine; Drug Combinations; Eicosapentaenoic Acid; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Leukotrienes; Lung; Neutrophils; Platelet Activating Factor; Pulmonary Circulation; Rabbits | 2000 |
Respective roles of the 14 kDa and 85 kDa phospholipase A2 enzymes in human monocyte eicosanoid formation.
Topics: Arachidonic Acid; Arachidonic Acids; Eicosanoids; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Leukotrienes; Models, Biological; Molecular Weight; Monocytes; Oligonucleotides, Antisense; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Prostaglandins; Sulfonamides | 1999 |
Inhibition of cytosolic phospholipase A(2) attenuates activation of mitogen-activated protein kinases in human monocytic cells.
Topics: Arachidonic Acid; CCAAT-Enhancer-Binding Proteins; Cell Line; Cytosol; DNA-Binding Proteins; Enzyme Activation; Gene Expression; Humans; Interleukin-1; Leukotriene B4; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Nuclear Proteins; Oligonucleotides, Antisense; Phospholipases A; Phosphorylation; Platelet Activating Factor; STAT1 Transcription Factor; Trans-Activators; Transcription Factor AP-1 | 2000 |
Modulation of PAF production by incorporation of arachidonic acid and eicosapentaenoic acid in phospholipids of human leukemic monocyte-like cells THP-1.
Topics: Acetates; Arachidonic Acid; Calcimycin; Eicosapentaenoic Acid; Humans; Ionophores; Leukemia, Monocytic, Acute; Phospholipids; Platelet Activating Factor; Tumor Cells, Cultured | 2000 |
Antiplatelet effect of marchantinquinone, isolated from Reboulia hemisphaerica, in rabbit washed platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; Arachidonic Acid; Bibenzyls; Blood Platelets; Calcium; Collagen; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Ethers, Cyclic; Phosphatidylinositols; Plants, Medicinal; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thrombin; Thromboxane B2 | 2000 |
Cellular regulation of cytosolic group IV phospholipase A2 by phosphatidylinositol bisphosphate levels.
Topics: Animals; Arachidonic Acid; Calcium Signaling; Cell Membrane; Cell Membrane Permeability; Cytosol; Enzyme Activation; Leukemia P388; Lipopolysaccharides; Macrophages; Mice; Phosphatidylinositol 4,5-Diphosphate; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Protein Kinase C; Proto-Oncogene Proteins c-raf; Tumor Cells, Cultured; Ultraviolet Rays | 2000 |
Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis.
Topics: Anaphylaxis; Animals; Arachidonic Acid; Ear, External; Female; Gene Targeting; Inflammation Mediators; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Peritoneum; Platelet Activating Factor; Receptors, Leukotriene B4; Zymosan | 2000 |
Uteroglobin reverts the transformed phenotype in the endometrial adenocarcinoma cell line HEC-1A by disrupting the metabolic pathways generating platelet-activating factor.
Topics: Acetyltransferases; Adenocarcinoma; Arachidonic Acid; Cell Cycle; Cell Division; Cell Membrane; Cell Transformation, Neoplastic; Endometrial Neoplasms; Female; Humans; Kinetics; Phospholipases A; Platelet Activating Factor; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Uteroglobin | 2000 |
Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Cell Line; Cell Membrane; Dinoprostone; Electrophoresis, Polyacrylamide Gel; Group II Phospholipases A2; Group V Phospholipases A2; Heparan Sulfate Proteoglycans; Heparin; Humans; Hydrogen-Ion Concentration; Hydrolysis; Immunohistochemistry; Leukotriene C4; Mast Cells; Mast-Cell Sarcoma; Mice; Microscopy, Confocal; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Phospholipases A; Phosphorylation; Platelet Activating Factor; Protein Binding; Rats; Recombinant Proteins; RNA; Sequence Homology, Amino Acid; Time Factors; Transfection; Tumor Cells, Cultured | 2001 |
Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents.
Topics: Alkanes; Arachidonic Acid; Collagen; Combinatorial Chemistry Techniques; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinolines; Structure-Activity Relationship; Thrombin | 2001 |
Leukotriene metabolism by intrapulmonary vessels of newborn lambs: effect of platelet-activating factor.
Topics: Animals; Animals, Newborn; Arachidonic Acid; Benzoquinones; In Vitro Techniques; Leukotriene B4; Leukotriene C4; Leukotriene D4; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Muscle, Smooth, Vascular; Platelet Activating Factor; Pulmonary Artery; Pulmonary Veins; Pyridinium Compounds; Sheep | 2001 |
Platelet-activating factor increases prostaglandin E(2) release from astrocyte-enriched cortical cell cultures.
Topics: Animals; Arachidonic Acid; Astrocytes; Binding Sites; Cells, Cultured; Cerebral Cortex; Dinoprostone; Diterpenes; Drug Synergism; Female; Ginkgolides; Lactones; Osmolar Concentration; Phospholipid Ethers; Platelet Activating Factor; Pyridinium Compounds; Rats; Solvents | 2002 |
Differential effects of arachidonoyl trifluoromethyl ketone on arachidonic acid release and lipid mediator biosynthesis by human neutrophils. Evidence for different arachidonate pools.
Topics: Acyltransferases; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cells, Cultured; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ionophores; Leukotriene B4; Leukotrienes; Lipid Metabolism; Lipoxygenase Inhibitors; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Platelet Activating Factor | 2002 |
Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica.
Topics: Adenosine Diphosphate; Alkaloids; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Diterpenes; Female; Fibrinolytic Agents; Ginkgolides; In Vitro Techniques; Indicators and Reagents; Lactones; Male; Plant Extracts; Plant Roots; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Spiraea | 2002 |
Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10.
Topics: Arachidonic Acid; Autocrine Communication; Azepines; Escherichia coli; Humans; In Vitro Techniques; Indoles; Interleukin-10; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Lipopolysaccharide Receptors; Lipopolysaccharides; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Prospective Studies; Respiratory Burst; Superoxides; Triazoles | 2002 |
Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway.
Topics: Antineoplastic Agents; Arachidonic Acid; Calcium; Cells, Cultured; Cytosol; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; Ionophores; Lung; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Platelet Activating Factor; Protein Serine-Threonine Kinases; Pyridines; Quinazolines; ras Proteins; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2002 |
Antiplatelet activity of benzylisoquinoline derivatives oxidized by cerium(IV) ammonium nitrate.
Topics: Arachidonic Acid; Aspirin; Benzylisoquinolines; Cerium; Collagen; Nitrates; Oxidation-Reduction; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Structure-Activity Relationship; Thrombin | 2003 |
Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Blood Platelets; In Vitro Techniques; Male; Naphthoquinones; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Rabbits | 2003 |
Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2.
Topics: Air Pollutants; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Autoradiography; Carbon Radioisotopes; Cells, Cultured; Chromatography, Thin Layer; Dinoprostone; Dogs; Enzyme Activation; Fatty Acids, Unsaturated; Hydrogen-Ion Concentration; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Macrophages, Alveolar; Phospholipases A; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Sulfates; Sulfites; Sulfur; Thromboxane B2 | 2003 |
Mechanisms of the priming effect of low doses of lipopoly-saccharides on leukocyte-dependent platelet aggregation in whole blood.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Blood; Blood Platelets; Cell Adhesion; Drug Interactions; Epinephrine; Humans; Leukocytes; Lipopolysaccharide Receptors; Lipopolysaccharides; Membrane Glycoproteins; Platelet Activating Factor; Platelet Aggregation; Receptors, Cell Surface; Toll-Like Receptor 4; Toll-Like Receptors | 2003 |
Effect of inhibitors of leukotriene and/or platelet activating factor on killed H. influenzae induced experimental otitis media with effusion.
Topics: Animals; Arachidonic Acid; Azepines; Case-Control Studies; Chinchilla; Chromatography, High Pressure Liquid; Haemophilus influenzae; Injections, Intraperitoneal; Leukotriene Antagonists; Leukotrienes; Naphthyridines; Otitis Media with Effusion; Platelet Activating Factor; Platelet Aggregation Inhibitors; Random Allocation; Temporal Bone; Triazoles | 2004 |
A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation.
Topics: Acute Disease; Animals; Arachidonic Acid; Carrageenan; Cells, Cultured; Convalescence; Corticosterone; Cyclooxygenase 2; Disease Progression; Enzyme Induction; Epithelial Cells; Fibroblasts; Group II Phospholipases A2; Group IV Phospholipases A2; Group V Phospholipases A2; Group VI Phospholipases A2; Interleukin-1; Isoenzymes; Leukotriene B4; Lipoxins; Macrophages; Male; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Pleurisy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar | 2004 |
Platelet hyperreactivity in hemodialysis patients with frequently occluded vascular access.
Topics: Adenosine Diphosphate; Arachidonic Acid; Calcium; Catheters, Indwelling; Diabetes Mellitus; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Activation; Renal Dialysis; Thrombin; Thrombosis | 2004 |
Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activ
Topics: Animals; Arachidonic Acid; Bronchoalveolar Lavage Fluid; CD11b Antigen; Cytosol; Dose-Response Relationship, Drug; Escherichia coli; Group IV Phospholipases A2; Humans; Inflammation; Ionomycin; Leukotriene B4; Mice; Mice, Transgenic; NADPH Oxidases; Neutrophils; Oxygen; Phagocytosis; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Pneumonia; Pyrrolidines; Receptors, IgG; Time Factors; Tumor Necrosis Factor-alpha | 2005 |
Structure-activity relationship studies on chalcone derivatives: potent inhibition of platelet aggregation.
Topics: Animals; Arachidonic Acid; Chalcones; Collagen; Epinephrine; Humans; Molecular Structure; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Structure-Activity Relationship; Thrombin | 2004 |
Defect in regulation of Ca2+ movement in platelets from patients with systemic lupus erythematosus.
Topics: Adenosine Diphosphate; Arachidonic Acid; Blood Platelets; Calcium; Calcium Signaling; Female; Fluorescent Dyes; Fura-2; Humans; Lupus Erythematosus, Systemic; Patients; Platelet Activating Factor; Thrombin | 2005 |
Calcium-independent phospholipase A2 is regulated by a novel protein kinase C in human coronary artery endothelial cells.
Topics: Arachidonic Acid; Cell Membrane; Cells, Cultured; Coronary Vessels; Endothelial Cells; Enzyme Activation; Group VI Phospholipases A2; Humans; Immunoblotting; Phospholipases A; Phospholipases A2; Phospholipids; Platelet Activating Factor; Polymerase Chain Reaction; Protein Isoforms; Protein Kinase C; Tetradecanoylphorbol Acetate; Thrombin | 2005 |
Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium.
Topics: Arachidonic Acid; Cell Adhesion; Cells, Cultured; Coronary Vessels; Electric Impedance; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Humans; Mast Cells; Naphthalenes; Neutrophils; Oligopeptides; P-Selectin; Phosphodiesterase Inhibitors; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Pyrones; Receptor, PAR-2; Serine Endopeptidases; Tryptases | 2005 |
Inhibitory effect of the Korean herbal medicine, Dae-Jo-Whan, on platelet-activating factor-induced platelet aggregation.
Topics: Animals; Arachidonic Acid; Dinoprostone; Dose-Response Relationship, Drug; Exocytosis; Fibrinolytic Agents; Korea; Male; Mice; Mice, Inbred ICR; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thromboxane A2 | 2005 |
Biological basis and clinical implications of acetylsalicylic acid resistance.
Topics: Acetylation; Acetyltransferases; Arachidonic Acid; Aspirin; Drug Resistance; Fibrinolytic Agents; Humans; Myocardial Infarction; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Stroke; Thromboxane A2 | 2006 |
Alpha-bulnesene, a novel PAF receptor antagonist isolated from Pogostemon cablin.
Topics: Animals; Arachidonic Acid; Blood Platelets; Calcium; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Models, Chemical; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Receptors, G-Protein-Coupled; Sesquiterpenes; Sesquiterpenes, Guaiane; Thromboxanes | 2006 |
Porphyromonas gingivalis lipopolysaccharide-induced cytosolic phospholipase A2 activation interferes with salivary mucin synthesis via platelet activating factor generation.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Cytosol; Endothelin-1; Enzyme Activation; Humans; Lipopolysaccharides; Mucins; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Porphyromonas gingivalis; Rats; Salivary Glands; Signal Transduction; Up-Regulation | 2006 |
Leptin modulates the detrimental effect of Porphyromonas gingivalis lipopolysaccharide-induced cytosolic phospholipase A2 activation on salivary mucin synthesis via ERK-signal transduction.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Cytosol; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Leptin; Lipopolysaccharides; Mucins; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Porphyromonas gingivalis; Rats; Signal Transduction; Sublingual Gland | 2006 |
Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetyltransferases; Antioxidants; Arachidonic Acid; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Endothelial Cells; Genistein; Glutathione; Humans; Hydrogen Peroxide; Maleates; Oxidants; Platelet Activating Factor; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Sulfonamides; Umbilical Veins | 2007 |
Interference by leptin with Helicobacter pylori lipopolysaccharide-induced cytosolic phospholipase A2 activation in gastric mucosal cells.
Topics: Androstadienes; Animals; Apoptosis; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gastric Mucins; Gastric Mucosa; Ginkgolides; Lactones; Leptin; Lipopolysaccharides; Organophosphonates; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Signal Transduction; Wortmannin | 2007 |
Antiplatelet aggregation coumarins from the leaves of Murraya omphalocarpa.
Topics: Animals; Arachidonic Acid; Blood Platelets; Collagen; Coumarins; Models, Molecular; Murraya; Plant Leaves; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thrombin; X-Ray Diffraction | 2008 |
[Study on composing mechanism by effect of disassembled compositions of Yiqi Huoxue decoction on platelet aggregation of health adults].
Topics: Adenosine Diphosphate; Adult; Angelica sinensis; Arachidonic Acid; Astragalus propinquus; Drug Combinations; Drug Synergism; Drugs, Chinese Herbal; Female; Humans; Male; Middle Aged; Plants, Medicinal; Platelet Activating Factor; Platelet Aggregation; Young Adult | 2007 |
Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Motifs; Animals; Apoptosis; Arachidonic Acid; Caspase 3; Cell Line; Chromones; Docosahexaenoic Acids; Enzyme Inhibitors; Epithelial Cells; Fatty Acids, Unsaturated; Gene Expression; Indomethacin; Intestines; Lipoylation; Models, Biological; Morpholines; Oncogene Protein v-akt; Palmitates; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Rats | 2008 |
(3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a class of novel antithrombotic agents: synthesis, bioassay, 3D QSAR, and ADME analysis.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Biological Assay; Dose-Response Relationship, Drug; Fibrinolytic Agents; Molecular Structure; Platelet Activating Factor; Platelet Aggregation; Quantitative Structure-Activity Relationship; Rats; Tetrahydroisoquinolines; Thrombin | 2008 |
Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium.
Topics: Arachidonic Acid; Cell Adhesion; Cells, Cultured; Endothelial Cells; Enzyme Activation; Epoprostenol; Group VI Phospholipases A2; Humans; Hypersensitivity; Inflammation Mediators; Lung; Naphthalenes; Neutrophils; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyrones; Thrombin; Tryptases | 2009 |
Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis.
Topics: Arachidonic Acid; Carbamates; Cells, Cultured; Enzyme Inhibitors; Exocytosis; Fluoroimmunoassay; Glucuronidase; Group IV Phospholipases A2; Humans; Immunoblotting; Indolizines; Ionophores; Lipopolysaccharides; Macrophages, Alveolar; Platelet Activating Factor; Polymerase Chain Reaction | 2009 |
Physalin B inhibits Rhodnius prolixus hemocyte phagocytosis and microaggregation by the activation of endogenous PAF-acetyl hydrolase activities.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Arachidonic Acid; Cell Aggregation; Enzyme Activation; Hemocytes; Insect Proteins; Phagocytosis; Platelet Activating Factor; Rhodnius; Saccharomyces cerevisiae; Secosteroids | 2009 |
Platelet activating factor stimulates arachidonic acid release in differentiated keratinocytes via arachidonyl non-selective phospholipase A2.
Topics: Arachidonic Acid; Calcium; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Group IV Phospholipases A2; Group VI Phospholipases A2; Humans; Inflammation; Inflammation Mediators; Ionophores; Isoenzymes; Keratinocytes; Organometallic Compounds; Phospholipase A2 Inhibitors; Phospholipases A2; Phospholipases A2, Secretory; Platelet Activating Factor; Signal Transduction; Sulfides | 2010 |
In vitro inhibitory activities of Lauraceae aporphine alkaloids.
Topics: Adenosine Diphosphate; Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aporphines; Arachidonic Acid; Circular Dichroism; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; In Vitro Techniques; Lauraceae; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Plant Extracts; Plant Leaves; Platelet Activating Factor; Platelet Aggregation; Rabbits | 2010 |
Endothelial cell prostaglandin I(2) and platelet-activating factor production are markedly attenuated in the calcium-independent phospholipase A(2)beta knockout mouse.
Topics: Animals; Arachidonic Acid; Endothelial Cells; Epoprostenol; Hydrolysis; Membrane Lipids; Mice; Mice, Knockout; Phospholipases A2, Calcium-Independent; Platelet Activating Factor; Thrombin; Tryptases | 2010 |
Multiple phospholipase A2 enzymes participate in the inflammatory process in osteoarthritic cartilage.
Topics: Aged; Aged, 80 and over; Arachidonic Acid; Cartilage, Articular; Cells, Cultured; Chondrocytes; Dinoprostone; Female; Humans; Inflammation; Interleukin-1beta; Isoenzymes; Male; Middle Aged; Oleic Acid; Osteoarthritis, Hip; Osteoarthritis, Knee; Phospholipases A2; Platelet Activating Factor; RNA, Messenger; Tumor Necrosis Factor-alpha | 2011 |
Report: Platelet aggregation inhibition activity of selected legumes of Pakistan.
Topics: Arachidonic Acid; Dose-Response Relationship, Drug; Fabaceae; Glycine max; Humans; Lens Plant; Methanol; Pakistan; Plant Extracts; Plants, Medicinal; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Seeds; Solvents | 2012 |
Anti-platelet activity of erythro-(7S,8R)-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan from Myristica fragrans.
Topics: Adult; Arachidonic Acid; Blood Platelets; Calcium; Calcium Signaling; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Lignans; Male; Myristica; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin; Thrombin; Thromboxane B2; Young Adult | 2013 |
Inhibition of human platelet aggregation by eosinophils.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Blood Platelets; Chromatography, Gel; Collagen; Cytosol; Dextrans; Eosinophils; HL-60 Cells; Humans; Indomethacin; Male; Molecular Weight; NG-Nitroarginine Methyl Ester; Platelet Activating Factor; Platelet Aggregation; Rats; Rats, Wistar; Thrombin; Time Factors | 2013 |
Aqueous extract of Rabdosia rubescens leaves: forming nanoparticles, targeting P-selectin, and inhibiting thrombosis.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Blood Coagulation; Blood Platelets; Chromatography, High Pressure Liquid; Cinnamates; Depsides; Flow Cytometry; Hydroxybenzoates; Isodon; Magnetic Resonance Spectroscopy; Male; Nanoparticles; P-Selectin; Plant Extracts; Plant Leaves; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Rosmarinic Acid; Spectrometry, Mass, Electrospray Ionization; Thrombin; Thrombosis | 2015 |
Bioactive chemical constituents from the root bark of Morus australis.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Dose-Response Relationship, Drug; Flavonoids; Mice; Molecular Structure; Morus; Nitric Oxide; Plant Roots; Platelet Activating Factor; Platelet Aggregation; Rabbits; RAW 264.7 Cells; Structure-Activity Relationship | 2017 |
Anti-platelet effects of anti-glaucomatous eye drops: an in vitro study on human platelets.
Topics: Adenosine Diphosphate; Arachidonic Acid; Blood Platelets; Glaucoma; Humans; Mediator Complex; Ophthalmic Solutions; Platelet Activating Factor; Platelet Aggregation | 2017 |
Anti-platelet effects of vitamin supplements in age-related macular degeneration: an in vitro study.
Topics: Adenosine Diphosphate; Arachidonic Acid; Blood Platelets; Dietary Supplements; Healthy Volunteers; Humans; Inhibitory Concentration 50; Macular Degeneration; Platelet Activating Factor; Platelet Aggregation; Receptors, Thrombin; Vitamins | 2018 |
Mechanisms and Treatment of Light-Induced Retinal Degeneration-Associated Inflammation: Insights from Biochemical Profiling of the Aqueous Humor.
Topics: Animals; Antioxidants; Aqueous Humor; Arachidonic Acid; Disease Models, Animal; Docosahexaenoic Acids; Edema; Inflammation; Light; Lipid Peroxidation; Macular Degeneration; Male; Mitochondria; Oxidative Stress; Oxylipins; Plastoquinone; Platelet Activating Factor; Rabbits; Retina; Retinal Degeneration | 2020 |
WFDC12-overexpressing contributes to the development of atopic dermatitis via accelerating ALOX12/15 metabolism and PAF accumulation.
Topics: Animals; Arachidonate 12-Lipoxygenase; Arachidonic Acid; Dermatitis, Atopic; Dinitrofluorobenzene; Humans; Mice; Platelet Activating Factor; Proteins; Skin | 2023 |