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1-hexadecyl-2-acetyl-glycero-3-phosphocholine and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one in 12 studies

Compound Research Comparison

Studies
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Trials
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Recent Studies (post-2010)
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Studies
(2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one)
Trials
(2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one)
Recent Studies (post-2010) (2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one)
9,1561875524,82351,810

Protein Interaction Comparison

ProteinTaxonomy1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50)2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one (IC50)
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1Homo sapiens (human)4
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1Homo sapiens (human)4
Chain A, Methyltransferase WbddEscherichia coli68
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)1.6413
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betaHomo sapiens (human)1.4218
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)1.002
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)9.614
Cytochrome P450 1A2Homo sapiens (human)1
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)1.6
Serine/threonine-protein kinase pim-1Homo sapiens (human)3.364
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)1.6
Casein kinase II subunit alpha'Homo sapiens (human)6.9
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)3.1638
5-hydroxytryptamine receptor 2AHomo sapiens (human)2.796
5-hydroxytryptamine receptor 2CHomo sapiens (human)1.002
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)2.3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformBos taurus (cattle)3.7533
Type-1 angiotensin II receptorOryctolagus cuniculus (rabbit)0.5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)1.4593
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Mus musculus (house mouse)0.5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)1.2922
Serine/threonine-protein kinase mTORHomo sapiens (human)4.1638
Serine/threonine-protein kinase mTORRattus norvegicus (Norway rat)2.5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)2.4845
Glycogen synthase kinase-3 betaHomo sapiens (human)8.1
Serine/threonine-protein kinase PLK1Homo sapiens (human)2.05
Casein kinase II subunit betaHomo sapiens (human)6.9
Casein kinase II subunit alphaHomo sapiens (human)6.9
DNA-dependent protein kinase catalytic subunitHomo sapiens (human)1.32
Mu-type opioid receptorCavia porcellus (domestic guinea pig)1.6
Serine/threonine-protein kinase pim-3Homo sapiens (human)1.4
Phosphoinositide 3-kinase regulatory subunit 5Homo sapiens (human)1.72
Serine/threonine-protein kinase PLK3Homo sapiens (human)3

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (33.33)18.2507
2000's8 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Duronio, V; Ettinger, SL; Lauener, RW1
Coffer, PJ; Geijsen, N; Koenderman, L; Lammers, JW; M'rabet, L; Maikoe, T; Raaijmakers, JA; Schweizer, RC1
Bruyneel, E; Chastre, E; Gespach, C; Kotelevets, L; Mareel, M; Myssiakine, E; Noë, V1
Duronio, V; Lauener, RW; Salari, H; Sayed, MR; Stevens, CM1
Bazan, NG; Bernatchez, PN; Gélinas, DS; Rollin, S; Sirois, MG1
Buckley, A; Chilvers, ER; Haslett, C; MacKinnon, AC; Rossi, AG; Sethi, T1
Cahana, A; Chandrakanthan, V; Ishii, S; Lu, DP; O'Neill, C1
Alloatti, G; Berta, G; Cappello, S; Gattullo, D; Losano, G; Mognetti, B; Pagliaro, P; Penna, C1
Chen, LW; Hsu, CM; Lin, MW1
Dent, G; Djukanovic, R; Gray, BC; Harb, Z; Mishra, RK; Scaife, JE1
Chandrakanthan, V; Day, ML; Li, Y; O'Neill, C1
Caplan, MS; Jilling, T; Li, D; Lu, J1

Other Studies

12 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

ArticleYear
Protein kinase C delta specifically associates with phosphatidylinositol 3-kinase following cytokine stimulation.
    The Journal of biological chemistry, 1996, Jun-14, Volume: 271, Issue:24

    Topics: Androstadienes; Animals; Blood Platelets; Cell Line; Chromones; Cytokines; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Interleukin-5; Isoenzymes; Leukemia, Basophilic, Acute; Leukemia, Erythroblastic, Acute; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet Activating Factor; Protein Binding; Protein Kinase C; Protein Kinase C-delta; Rabbits; Rats; Receptors, IgE; Recombinant Proteins; Tumor Cells, Cultured; Wortmannin

1996
Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function.
    The Biochemical journal, 1998, Jan-01, Volume: 329 ( Pt 1)

    Topics: Androstadienes; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Chemotactic Factors; Chemotaxis, Leukocyte; Chromones; Cytokines; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Activating Factor; Protein Kinase Inhibitors; Protein Kinases; Respiratory Burst; Signal Transduction; Wortmannin; Zymosan

1998
Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion.
    The Journal of biological chemistry, 1998, Jun-05, Volume: 273, Issue:23

    Topics: Androstadienes; Animals; Azepines; Cell Adhesion Molecules; Cell Movement; Chromones; Colonic Neoplasms; Dogs; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Genes, src; GTP-Binding Proteins; Hepatocyte Growth Factor; Humans; Intestinal Mucosa; Kidney; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Thiazoles; Transformation, Genetic; Triazoles; Tumor Cells, Cultured; Virulence Factors, Bordetella; Wortmannin

1998
A role for phosphatidylinositol 3-kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin.
    Biochimica et biophysica acta, 1999, Nov-11, Volume: 1452, Issue:2

    Topics: Androstadienes; Animals; Blood Platelets; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thrombin; Wortmannin

1999
Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways.
    British journal of pharmacology, 2002, Volume: 137, Issue:7

    Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Animals; Calcimycin; Calcium; Cattle; Cells, Cultured; Chelating Agents; Chromones; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Egtazic Acid; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Ginkgolides; Indoles; Intercellular Signaling Peptides and Proteins; Ionophores; Lactones; Lymphokines; Maleimides; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serine; Signal Transduction; Time Factors; Type C Phospholipases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin

2002
Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Dec-01, Volume: 169, Issue:11

    Topics: Adult; Apoptosis; Calcium Signaling; Cell Polarity; Cell Size; Chromones; Enzyme Activation; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptide Fragments; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Recombinant Proteins; Respiratory Burst; Signal Transduction; Sphingosine; Substance P; Superoxides; Tumor Necrosis Factor-alpha

2002
Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development.
    Journal of cell science, 2004, Mar-15, Volume: 117, Issue:Pt 8

    Topics: Androstadienes; Animals; Blastocyst; Calcium Signaling; Chromones; Culture Media; Culture Techniques; Dose-Response Relationship, Drug; Embryonic Development; Enzyme Inhibitors; Female; Mice; Mice, Knockout; Morpholines; Morula; Phosphatidylinositol 3-Kinases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pregnancy; Receptors, G-Protein-Coupled; RNA, Messenger; Wortmannin; Zygote

2004
Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:5

    Topics: Alkaloids; Animals; Azepines; Benzophenanthridines; Cardiotonic Agents; Chromones; Coronary Circulation; Enzyme Inhibitors; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Morpholines; Myocardial Reperfusion Injury; Myocardium; Necrosis; Perfusion; Phenanthridines; Phosphatidylinositol 3-Kinases; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Kinase C; Rats; Rats, Wistar; Triazoles; Ventricular Function, Left

2005
Different pathways leading to activation of extracellular signal-regulated kinase and p38 MAP kinase by formyl-methionyl-leucyl-phenylalanine or platelet activating factor in human neutrophils.
    Journal of biomedical science, 2005, Volume: 12, Issue:2

    Topics: Androstadienes; Aristolochic Acids; Calcium; Calcium Channel Blockers; Calcium Channels; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Indoles; Maleimides; Models, Biological; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Naphthalenes; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein Isoforms; Protein Kinase C; Pyrrolidinones; Type C Phospholipases; Wortmannin

2005
Differential dependence of eosinophil chemotactic responses on phosphoinositide 3-kinase (PI3K).
    Allergy, 2005, Volume: 60, Issue:9

    Topics: Androstadienes; Cells, Cultured; Chemokine CCL11; Chemokines, CC; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Chromones; Eosinophils; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Platelet Activating Factor; Protein Kinase Inhibitors; Signal Transduction; Wortmannin

2005
Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo.
    Biology of reproduction, 2007, Volume: 77, Issue:5

    Topics: Animals; Blastocyst; Calcium; Chromones; Embryo, Mammalian; Mice; Mice, Mutant Strains; Morpholines; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Platelet Activating Factor; Proto-Oncogene Proteins c-akt; RNA, Messenger; Rotenone; Signal Transduction; Zygote

2007
Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells.
    American journal of physiology. Gastrointestinal and liver physiology, 2008, Volume: 294, Issue:5

    Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Motifs; Animals; Apoptosis; Arachidonic Acid; Caspase 3; Cell Line; Chromones; Docosahexaenoic Acids; Enzyme Inhibitors; Epithelial Cells; Fatty Acids, Unsaturated; Gene Expression; Indomethacin; Intestines; Lipoylation; Models, Biological; Morpholines; Oncogene Protein v-akt; Palmitates; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Rats

2008