Page last updated: 2024-09-02

1-hexadecyl-2-acetyl-glycero-3-phosphocholine and 1-methyl-3-isobutylxanthine

1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with 1-methyl-3-isobutylxanthine in 14 studies

Compound Research Comparison

Studies
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Trials
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Recent Studies (post-2010)
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
Studies
(1-methyl-3-isobutylxanthine)
Trials
(1-methyl-3-isobutylxanthine)
Recent Studies (post-2010) (1-methyl-3-isobutylxanthine)
9,1561875525,1485279

Protein Interaction Comparison

ProteinTaxonomy1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50)1-methyl-3-isobutylxanthine (IC50)
Chain A, High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7AHomo sapiens (human)8.1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)31
Chain A, Phosphodiesterase 9AHomo sapiens (human)500
Chain A, Class I phosphodiesterase PDEB1Leishmania major580
Chain A, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)698
Chain A, cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)40
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AHomo sapiens (human)117.2
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AHomo sapiens (human)117.2
Phosphodiesterase Bos taurus (cattle)9.9
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)4
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)3.1667
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Bos taurus (cattle)9.9
Adenosine receptor A1Rattus norvegicus (Norway rat)7
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AHomo sapiens (human)3.4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BBos taurus (cattle)9.9
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)3.4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BRattus norvegicus (Norway rat)0.1
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)0.242
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)3.4
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)7
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CRattus norvegicus (Norway rat)0.1
Phosphodiesterase Rattus norvegicus (Norway rat)0.1

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19904 (28.57)18.7374
1990's9 (64.29)18.2507
2000's1 (7.14)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chilton, FH; Goldman, D; Torphy, TJ; Undem, BJ1
Fernandez-Gallardo, S; Garcia, C; Garcia, MC; Gijon, MA; Nieto, ML; Sanchez Crespo, M1
Antonelli, T; Bacciarelli, C; Ballati, L; Beani, L; Borea, PA; Giachetti, A; Manzini, S; Meini, S1
Rink, TJ; Sage, SO1
Cox, CP1
Keery, RJ; Lumley, P1
Haslam, RJ; Vanderwel, M1
Abelli, L; Evangelista, S; Manzini, S; Page, CP; Perretti, F; Seeds, EA1
Alessio, P; Bussolino, F; Calvino, R; Fruttero, R; Gasco, A; Ghigo, D; Heller, R; Pescarmona, G; Till, U; Todde, R1
Alkon, DL; Inoue, H; Kouchi, T; Sakakibara, M; Yoshioka, T1
Columbo, M; Horowitz, EM; Kagey-Sobotka, A; Lichtenstein, LM; McKenzie-White, J1
Tool, AT; Verhoeven, AJ1
Bergamaschi, M; Bongrani, S; Caruso, P; Civelli, M; Gasco, A; Giossi, M; Razzetti, R1
Bazan, NG; Bernatchez, PN; GĂ©linas, DS; Rollin, S; Sirois, MG1

Other Studies

14 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and 1-methyl-3-isobutylxanthine

ArticleYear
Inhibition by adenosine 3':5'-monophosphate of eicosanoid and platelet-activating factor biosynthesis in the mouse PT-18 mast cell.
    The Journal of biological chemistry, 1990, Apr-25, Volume: 265, Issue:12

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Cell Line; Colforsin; Cyclic AMP; Eicosanoids; Kinetics; Leukotrienes; Mast Cells; Mice; Platelet Activating Factor; Prostaglandin D2; Theophylline

1990
Biosynthesis of platelet-activating factor (PAF) in human polymorphonuclear leucocytes. The role of lyso-PAF disposal and free arachidonic acid.
    The Biochemical journal, 1990, May-15, Volume: 268, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Acetyltransferases; Acyltransferases; Arachidonic Acid; Arachidonic Acids; Calcimycin; Coenzyme A Ligases; Fatty Acids; Humans; Kinetics; Leukotriene B4; Neutrophils; Platelet Activating Factor; Theophylline

1990
Pharmacodynamic profile of isbufylline, a new antibronchospastic xanthine devoid of central excitatory actions.
    Arzneimittel-Forschung, 1990, Volume: 40, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Anticonvulsants; Blood Pressure; Brain Chemistry; Bronchial Spasm; Bronchodilator Agents; Electroencephalography; Female; Gastrointestinal Transit; Guinea Pigs; Hemodynamics; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Parasympatholytics; Phosphodiesterase Inhibitors; Platelet Activating Factor; Rats; Rats, Inbred Strains; Receptors, Purinergic; Sleep; Trachea

1990
Inhibition by forskolin of cytosolic calcium rise, shape change and aggregation in quin2-loaded human platelets.
    FEBS letters, 1985, Aug-19, Volume: 188, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Blood Platelets; Calcium; Colforsin; Cyclic AMP; Cytosol; Diterpenes; Fluorescent Dyes; Humans; Platelet Activating Factor; Platelet Aggregation; Thrombin

1985
Effects of CV-3988, an antagonist of platelet-activating factor (PAF), on washed rabbit platelets.
    Thrombosis research, 1986, Jan-15, Volume: 41, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Platelets; Calcimycin; Collagen; Cyclic AMP; Dose-Response Relationship, Drug; Epoprostenol; Female; Osmolar Concentration; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thiazoles

1986
AH6809, a prostaglandin DP-receptor blocking drug on human platelets.
    British journal of pharmacology, 1988, Volume: 94, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine; Adenosine Diphosphate; Adenosine-5'-(N-ethylcarboxamide); Dinoprost; Epoprostenol; Humans; Hydantoins; In Vitro Techniques; Male; Platelet Activating Factor; Platelet Aggregation; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Receptors, Immunologic; Receptors, Prostaglandin; Xanthenes; Xanthones

1988
Inhibition of platelet adenylate cyclase by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (platelet-activating factor).
    The Journal of biological chemistry, 1982, Jun-25, Volume: 257, Issue:12

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Creatine Kinase; Cyclic AMP; Indomethacin; Lysophosphatidylcholines; Phosphocreatine; Platelet Activating Factor; Prostaglandins E; Rabbits

1982
Isbufylline, a new xanthine derivative, inhibits airway hyperresponsiveness and airway inflammation in guinea pigs.
    European journal of pharmacology, 1993, Nov-16, Volume: 249, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Albuterol; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Capsaicin; Dextrans; Dyspnea; Fluorescein-5-isothiocyanate; Guinea Pigs; Histamine; Leukocytes; Male; Ovalbumin; Platelet Activating Factor

1993
S35b, a new phenylsulfonylfuroxan compound, inhibits thrombin-induced synthesis of platelet-activating factor and prostacyclin in human endothelial cells.
    Agents and actions, 1993, Volume: 40, Issue:3-4

    Topics: 1-Methyl-3-isobutylxanthine; Acetyltransferases; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Humans; Iloprost; Oxadiazoles; Platelet Activating Factor; Platelet Aggregation Inhibitors; Thrombin; Umbilical Veins

1993
Induction of photoresponse by the hydrolysis of polyphosphoinositides in the Hermissenda type B photoreceptor.
    Biochemical and biophysical research communications, 1994, Jul-15, Volume: 202, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Hydrolysis; Inositol 1,4,5-Trisphosphate; Kinetics; Lithium Chloride; Models, Biological; Neomycin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Photoreceptor Cells, Invertebrate; Platelet Activating Factor; Pyrimidinones; Snails; Spermine; Thiazoles; Thionucleotides; Type C Phospholipases

1994
Pharmacologic control of histamine release from human basophils induced by platelet-activating factor.
    International archives of allergy and immunology, 1993, Volume: 102, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Basophils; Cyclic AMP; Enzyme Inhibitors; Histamine Release; Humans; Pertussis Toxin; Platelet Activating Factor; Verapamil; Virulence Factors, Bordetella

1993
Inhibition of the production of platelet activating factor and of leukotriene B4 in activated neutrophils by nimesulide due to an elevation of intracellular cyclic adenosine monophosphate.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:10

    Topics: 1-Methyl-3-isobutylxanthine; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytochalasin B; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoquinolines; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphodiesterase Inhibitors; Platelet Activating Factor; Protein Kinase Inhibitors; Sulfonamides; Zymosan

1995
The involvement of the release of nitric oxide in the pharmacological activity of the new furoxan derivative CHF 2363.
    British journal of pharmacology, 1996, Volume: 118, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Oxadiazoles; Phosphodiesterase Inhibitors; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Vasodilator Agents

1996
Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways.
    British journal of pharmacology, 2002, Volume: 137, Issue:7

    Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Animals; Calcimycin; Calcium; Cattle; Cells, Cultured; Chelating Agents; Chromones; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Egtazic Acid; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Ginkgolides; Indoles; Intercellular Signaling Peptides and Proteins; Ionophores; Lactones; Lymphokines; Maleimides; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serine; Signal Transduction; Time Factors; Type C Phospholipases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin

2002