1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene has been researched along with mitotane in 4 studies
| Studies (1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene) | Trials (1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene) | Recent Studies (post-2010) (1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene) | Studies (mitotane) | Trials (mitotane) | Recent Studies (post-2010) (mitotane) |
|---|---|---|---|---|---|
| 18 | 0 | 1 | 895 | 38 | 290 |
| Protein | Taxonomy | 1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene (IC50) | mitotane (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 10 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.819 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 7.347 | |
| Adenosine receptor A3 | Homo sapiens (human) | 7.445 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 7.445 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.819 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 3.015 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 4.832 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 7.445 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 1.402 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 1.001 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jönsson, CJ; Lund, BO | 1 |
| Brandt, I; Lindhe, O; Skogseid, B | 1 |
| Bergman, A; Brandt, I; Cantillana, T; Hermansson, V; Hovander, L; Ljungvall, K; Magnusson, U; Törneke, K | 1 |
| Asp, V; Bergman, A; Bergström, U; Brandt, I; Hermansson, V | 1 |
4 other study(ies) available for 1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene and mitotane
| Article | Year |
|---|---|
In vitro bioactivation of the environmental pollutant 3-methylsulphonyl-2, 2-bis(4-chlorophenyl)-1,1-dichloroethene in the human adrenal gland.
Topics: Adrenal Glands; Binding Sites; Biotransformation; Cytochrome P-450 Enzyme System; Dichlorodiphenyl Dichloroethylene; Female; Glutathione; Humans; In Vitro Techniques; Metyrapone; Middle Aged; Mitochondria; Mitotane; Protein Binding | 1994 |
Cytochrome P450-catalyzed binding of 3-methylsulfonyl-DDE and o,p'-DDD in human adrenal zona fasciculata/reticularis.
Topics: Adult; Autoradiography; Cytochrome P-450 Enzyme System; Dichlorodiphenyl Dichloroethylene; Female; Hormones; Humans; In Vitro Techniques; Male; Middle Aged; Mitotane; Zona Fasciculata; Zona Reticularis | 2002 |
Pharmacokinetics of the adrenocorticolytic compounds 3-methylsulphonyl-DDE and o,p'-DDD (mitotane) in Minipigs.
Topics: Adipose Tissue; Adrenal Cortex; Animals; Antineoplastic Agents, Hormonal; Area Under Curve; Biotransformation; Chromatography, Gas; Data Interpretation, Statistical; Dichlorodiphenyl Dichloroethylene; Electrochemistry; Liver; Mitotane; Subcutaneous Fat; Swine; Swine, Miniature; Tissue Distribution | 2008 |
Comparative CYP-dependent binding of the adrenocortical toxicants 3-methylsulfonyl-DDE and o,p'-DDD in Y-1 adrenal cells.
Topics: Adrenal Glands; Animals; Cell Line; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dichlorodiphenyl Dichloroethylene; Female; Glutathione; Mice; Mice, Inbred C57BL; Mitotane; Protein Binding; Sulfhydryl Compounds | 2007 |