Compounds > 1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene
Page last updated: 2024-09-03

1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene and metyrapone

1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene has been researched along with metyrapone in 3 studies

Compound Research Comparison

Studies
(1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene)		Trials
(1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene)		Recent Studies (post-2010)
(1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene)		Studies
(metyrapone)		Trials
(metyrapone)		Recent Studies (post-2010) (metyrapone)
18013,415128250

Protein Interaction Comparison

ProteinTaxonomy1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene (IC50)metyrapone (IC50)
Cytochrome P450 1A2Homo sapiens (human)4.8
Cytochrome P450 3A4Homo sapiens (human)2.8659
Cytochrome P450 2C8Homo sapiens (human)5
Cytochrome P450 2D6Homo sapiens (human)4.6
Cytochrome P450 11B1, mitochondrial Bos taurus (cattle)7.83
Cytochrome P450 11B1, mitochondrialRattus norvegicus (Norway rat)4.7357
Cytochrome P450 11B1, mitochondrialHomo sapiens (human)0.0181
Cytochrome P450 11B2, mitochondrialHomo sapiens (human)0.0838
Cytochrome P450 2C19Homo sapiens (human)5

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bergman, A; Brandt, I; Lund, BO1
Jönsson, CJ; Lund, BO1
Johansson, MK; Lund, BO; Sanderson, JT1

Other Studies

3 other study(ies) available for 1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene and metyrapone

ArticleYear
Metabolic activation and toxicity of a DDT-metabolite, 3-methylsulphonyl-DDE, in the adrenal zona fasciculata in mice.
    Chemico-biological interactions, 1988, Volume: 65, Issue:1

    Topics: Adrenal Cortex; Animals; Biotransformation; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dichlorodiphenyl Dichloroethylene; Epoxide Hydrolases; Epoxy Compounds; Female; Glutathione; Metyrapone; Mice; Mice, Inbred C57BL; Necrosis; Protein Binding; Tissue Distribution

1988
In vitro bioactivation of the environmental pollutant 3-methylsulphonyl-2, 2-bis(4-chlorophenyl)-1,1-dichloroethene in the human adrenal gland.
    Toxicology letters, 1994, Volume: 71, Issue:2

    Topics: Adrenal Glands; Binding Sites; Biotransformation; Cytochrome P-450 Enzyme System; Dichlorodiphenyl Dichloroethylene; Female; Glutathione; Humans; In Vitro Techniques; Metyrapone; Middle Aged; Mitochondria; Mitotane; Protein Binding

1994
Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line.
    Toxicology in vitro : an international journal published in association with BIBRA, 2002, Volume: 16, Issue:2

    Topics: Adrenal Cortex Neoplasms; Aminoglutethimide; Carcinoma; Chromatography, High Pressure Liquid; Colforsin; Cytochrome P-450 Enzyme Inhibitors; Dichlorodiphenyl Dichloroethylene; Dose-Response Relationship, Drug; Drug Combinations; Environmental Pollutants; Enzyme Inhibitors; Hydrocortisone; Ketoconazole; Metyrapone; Tumor Cells, Cultured

2002