1-benzylpiperidine has been researched along with piperidines in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.11) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 17 (62.96) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y; Collantes, ER; Tong, W; Welsh, WJ | 1 |
| Bernard, P; Chrétien, JR; Coppet, L; Fortier, PL; Kireev, DB | 1 |
| Badia, A; Baños, JE; Castro, A; Conde, S; Fernandez, E; Martinez, A; Rodriguez-Franco, I | 1 |
| PODVALOVA, I; VOTAVA, Z | 2 |
| CAVALLITO, CJ; MILLER, LD; NAPOLI, MD; O'DELL, TB | 1 |
| Kajos, M; Kankaanpää, A; Meririnne, E; Seppälä, T | 1 |
| Baumann, MH; Blough, BE; Mello, NK; Negus, SS; Rothman, RB | 1 |
| Chai, Y; Jiang, K; Pan, Y | 1 |
| Bajda, M; Guzior, N; Malawska, B; Więckowska, A | 1 |
| Chioua, M; Estrada, M; Iriepa, I; Marco-Contelles, J; Moraleda, I; Pérez, C; Rodríguez-Franco, MI; Samadi, A | 1 |
| Alipour, M; Asadipour, A; Emami, S; Foroumadi, A; Homayouni Moghadam, F; Jafari, M; Khoobi, M; Moradi, A; Nadri, H; Sakhteman, A; Shafiee, A; Sheibani, V | 1 |
| Ismaïli, L; Iutzeler, A; Luzet, V; Pudlo, M; Refouvelet, B; Tomassoli, I | 1 |
| Isensee, K; Odadzic, D; Odazic, D; Schwed, JS; Stark, H; Weizel, L; Wingen, K; Zivković, A | 1 |
| Bautista-Aguilera, OM; Chioua, M; Colmena, I; Criado, M; Gandía, L; Marco-Contelles, J; Mulet, J; Sala, F; Sala, S; Samadi, A | 1 |
| Estrada, M; Herrera-Arozamena, C; Morales-García, JA; Pérez, C; Pérez-Castillo, A; Rodríguez-Franco, MI; Romero, A; Viña, D | 1 |
| Jamison, TF; Katcher, MH; Seo, H | 1 |
| Bitam, S; Hamadache, M; Hanini, S | 1 |
| Acharya, S; Cheon, SH; Khadka, DB; Kim, KM; Min, X; Paudel, S; Yoon, G | 2 |
| Campillo, NE; Carvalho, I; de Andrade, P; Gonçalves Nunes, PS; Hojo, ETS; Magadán, CR; Mantoani, SP; Martínez, A; Pérez, C; Xavier, DJ | 1 |
| Krishnamurthy, S; Prajapati, SK; Seth, A; Sharma, P; Shrivastava, SK; Srivastava, P; Tiwari, V; Tripathi, A; Tripathi, MK; Tripathi, PN | 1 |
| Cordier, W; Johan van der Westhuizen, C; Nell, M; Panayides, JL; Riley, DL; Stander, A; Steenkamp, V; van Greunen, DG | 1 |
| Sharma, P; Shrivastava, SK; Singh, SP; Singh, SS; Tripathi, A; Tripathi, PN | 1 |
| Liu, X; Peng, J; Sun, W; Yan, H; Zhang, L; Zhou, Y; Zuo, Z | 1 |
| Chen, C; Chen, H; Cheng, K; Li, M; Liu, J; Liu, S; Sun, H; Wang, Y; Wen, X; Xu, QL; Yuan, H; Zhou, J; Zhou, S; Zhou, X | 1 |
| Akbarzadeh, T; Edraki, N; Felegari, P; Firuzi, O; Hariri, R; Iraji, A; Mahdavi, M; Mirfazli, SS; Rastegari, A; Saeedi, M | 1 |
27 other study(ies) available for 1-benzylpiperidine and piperidines
| Article | Year |
|---|---|
A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Models, Molecular; Piperidines | 1996 |
Automated docking of 82 N-benzylpiperidine derivatives to mouse acetylcholinesterase and comparative molecular field analysis with 'natural' alignment.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Mice; Models, Molecular; Piperidines; Protein Binding; Static Electricity; Structure-Activity Relationship | 1999 |
N-Benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Male; Models, Molecular; Neuromuscular Blocking Agents; Piperidines; Rats; Rats, Sprague-Dawley; Thiadiazines | 2000 |
[Pharmacological study on synthetic ecbolics; substituted N-benzylpiperidines and 3, 4-dimethoxybenzylamines].
Topics: Amines; Female; Humans; Piperidines; Uterus | 1956 |
Pharmacological research of synthetic uterotonics. II. Substituted N-benzylpiperidines and 3,4-dimethoxybenzylamines].
Topics: Amines; Benzylamines; Female; Humans; Oxytocics; Piperidines; Uterus | 1954 |
Effectiveness of 1-dimethylaminoethyl-4-benzylpiperidine (IN379) in prevention and regression of experimental atherosclerosis in the rabbit.
Topics: Animals; Arteriosclerosis; Atherosclerosis; Piperidines; Rabbits | 1962 |
Rewarding properties of 1-benzylpiperazine, a new drug of abuse, in rats.
Topics: Animals; Behavior, Animal; Benzazepines; Conditioning, Psychological; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Ketanserin; Male; Piperidines; Psychotropic Drugs; Raclopride; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Serotonin, 5-HT2; Receptors, Serotonin, 5-HT3; Reward; Serotonin 5-HT2 Receptor Antagonists; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Substance-Related Disorders; Tropanes | 2006 |
Selective suppression of cocaine- versus food-maintained responding by monoamine releasers in rhesus monkeys: benzylpiperazine, (+)phenmetrazine, and 4-benzylpiperidine.
Topics: Animals; Biogenic Monoamines; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Discrimination, Psychological; Dopamine; Dopamine Uptake Inhibitors; Food; Macaca mulatta; Male; Norepinephrine; Phenmetrazine; Piperazines; Piperidines; Reward; Serotonin; Synaptosomes | 2009 |
Hydride transfer reactions via ion-neutral complex: fragmentation of protonated N-benzylpiperidines and protonated N-benzylpiperazines in mass spectrometry.
Topics: Cycloheptanes; Piperazines; Piperidines; Protons; Spectrometry, Mass, Electrospray Ionization; Thermodynamics; Toluene | 2010 |
Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Enzyme Activation; Kinetics; Models, Molecular; Molecular Structure; Piperazines; Piperidines; Stereoisomerism; Structure-Activity Relationship | 2010 |
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminopyridines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Enzyme Assays; Humans; Indans; Models, Biological; Models, Molecular; Nitriles; Permeability; Piperidines; Protein Binding; Pyridines; Structure-Activity Relationship | 2012 |
Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Amides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumarins; Dose-Response Relationship, Drug; Electrophorus; Horses; Models, Molecular; Molecular Structure; Piperidines; Structure-Activity Relationship | 2013 |
Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Antioxidants; Binding Sites; Catalytic Domain; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Piperidines; Quinolones; Structure-Activity Relationship | 2014 |
Benzylpiperidine variations on histamine H3 receptor ligands for improved drug-likeness.
Topics: Histamine Antagonists; Humans; Kinetics; Ligands; Piperidines; Protein Binding; Receptors, Histamine H3 | 2014 |
N-Benzylpiperidine Derivatives as α7 Nicotinic Receptor Antagonists.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Line, Tumor; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Isoxazoles; Membrane Potentials; Microinjections; Neuroblastoma; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Piperidines; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Serotonin; Xenopus laevis | 2016 |
New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.
Topics: Alzheimer Disease; Amines; Animals; Antioxidants; Cell Line, Tumor; Cholinesterases; Drug Design; Humans; Male; Mice; Molecular Targeted Therapy; Monoamine Oxidase; Neuroprotective Agents; Piperidines | 2016 |
Photoredox activation of carbon dioxide for amino acid synthesis in continuous flow.
Topics: Amino Acids; Carbon Dioxide; Catalysis; Free Radicals; Models, Chemical; Molecular Structure; Oxidation-Reduction; Photochemistry; Piperidines; Terphenyl Compounds; Ultraviolet Rays | 2017 |
QSAR model for prediction of the therapeutic potency of N-benzylpiperidine derivatives as AChE inhibitors.
Topics: Algorithms; Cholinesterase Inhibitors; Neural Networks, Computer; Piperidines; Quantitative Structure-Activity Relationship | 2017 |
Triple reuptake inhibitors: Design, synthesis and structure-activity relationship of benzylpiperidine-tetrazoles.
Topics: Dopamine; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperidines; Serotonin; Structure-Activity Relationship; Tetrazoles | 2017 |
Design, synthesis, and systematic evaluation of 4-arylpiperazine- and 4-benzylpiperidine napthyl ethers as inhibitors of monoamine neurotransmitters reuptake.
Topics: Antidepressive Agents; Drug Design; HEK293 Cells; Humans; Molecular Docking Simulation; Norepinephrine; Piperazine; Piperidines; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin and Noradrenaline Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins | 2018 |
Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease.
Topics: Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Click Chemistry; Drug Design; Drug Discovery; Humans; Molecular Docking Simulation; Piperidines; Structure-Activity Relationship | 2019 |
Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Blood-Brain Barrier; Cell Line, Tumor; Cholinesterase Inhibitors; Cognitive Dysfunction; Drug Design; Humans; Mice; Piperidines; Protein Aggregation, Pathological; Structure-Activity Relationship | 2019 |
Novel N-benzylpiperidine carboxamide derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Eels; Horses; Humans; Models, Molecular; Molecular Structure; Piperidines; Structure-Activity Relationship | 2019 |
Novel Molecular Hybrids of
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Drug Design; Molecular Docking Simulation; Oxadiazoles; Piperidines; Rats; Structure-Activity Relationship | 2019 |
Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments.
Topics: Acetylcholinesterase; Blood-Brain Barrier; Chelating Agents; Cholinesterase Inhibitors; Copper; Drug Design; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Piperidines; Pyridines; Structure-Activity Relationship | 2019 |
N-benzylpiperidinol derivatives as novel USP7 inhibitors: Structure-activity relationships and X-ray crystallographic studies.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Piperidines; Structure-Activity Relationship; Ubiquitin-Specific Peptidase 7 | 2020 |
Novel N-benzylpiperidine derivatives of 5-arylisoxazole-3-carboxamides as anti-Alzheimer's agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Isoxazoles; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents; PC12 Cells; Piperidines; Rats; Structure-Activity Relationship | 2021 |