1-amino-1,3-dicarboxycyclopentane has been researched along with quisqualic acid in 114 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.75) | 18.7374 |
| 1990's | 97 (85.09) | 18.2507 |
| 2000's | 14 (12.28) | 29.6817 |
| 2010's | 1 (0.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Allgeier, H; Knöpfel, T; Kuhn, R | 1 |
| Costantino, G; Pellicciari, R | 1 |
| Guiramand, J; Martinez, J; Récasens, M; Receveur, JM; Roumestant, ML; Viallefont, P | 1 |
| Acher, FC; Brabet, I; Jullian, N; Pin, JP | 1 |
| Costantino, G; Macchiarulo, A; Pellicciari, R | 1 |
| Bräuner-Osborne, H; Egebjerg, J; Krogsgaard-Larsen, P; Madsen, U; Nielsen, EO | 1 |
| Adam, G; Bleuel, Z; Chaboz, S; Ellis, GJ; Faull, RL; Malherbe, P; Messer, J; Metzler, V; Mutel, V; Nilly, A; Richards, JG; Roughley, BS; Schlaeger, EJ | 1 |
| Bischoff, F; Janssen, C; Langlois, X; Lavreysen, H; Lesage, AS; Leysen, JE | 1 |
| Acher, F; Bertrand, HO; Brabet, I; Pin, JP; Triballeau, N | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Li, PP; Vecil, GG; Warsh, JJ | 1 |
| Hu, GY; Storm, JF | 1 |
| Sheardown, MJ | 1 |
| Bockaert, J; Curry, K; Homburger, V; Manzoni, O; Prezeau, L; Sladeczek, F | 1 |
| Gallagher, JP; Zheng, F | 1 |
| Crill, W; Greene, C; Schwindt, P | 1 |
| de Barry, J; Kudo, Y; Takagi, H; Takimizu, H; Yoshioka, T | 1 |
| Boss, V; Conn, PJ | 1 |
| Baird, JG; Challiss, RA; Nahorski, SR | 1 |
| Courtney, MJ; Nicholls, DG | 1 |
| Charpak, S; Gähwiler, BH | 1 |
| Cotman, CW; Whittemore, ER | 1 |
| Lanthorn, TH; Monaghan, DT; Watson, GB | 1 |
| Corden, M; Curry, K; McLennan, H | 1 |
| Ito, I; Sugiyama, H; Tanabe, S | 1 |
| Bockaert, J; Dumuis, A; Oomagari, K; Pin, JP; Sebben, M | 1 |
| Courtney, MJ; Lambert, JJ; Nicholls, DG | 1 |
| Charpak, S; Do, KQ; Gähwiler, BH; Knöpfel, T | 1 |
| Cotman, CW; Monaghan, DT; Palmer, E | 1 |
| Baraban, JM; Stratton, KR; Worley, PF | 1 |
| MacDermott, AB; Reichling, DB | 1 |
| Connor, JA; Linden, DJ; Smeyne, M | 1 |
| Fox, EA; Gruol, DL | 1 |
| Glowinski, J; Prémont, J; Stella, N; Tencé, M | 1 |
| Klitgaard, H; Laudrup, P | 1 |
| Johnson, BG; Schoepp, DD | 1 |
| Amico, C; Condorelli, DF; Dell'Albani, P; Giuffrida-Stella, AM; Kaczmarek, L; Lukasiuk, K | 1 |
| Cavanni, P; Eistetter, H; Ferraguti, F; Ratti, E; Salvagno, C; Trist, DG | 1 |
| Dowling, JE; Grant, GB | 1 |
| Acciarri, N; Beani, L; Bianchi, C; Calo, G; Fabrizi, A; Ferraro, L; Morari, M; Piazza, G | 1 |
| Chung, SH; Premkumar, L | 1 |
| Cox, AJ; Lee, RK; Nitsch, RM; Wurtman, RJ | 1 |
| Miles, R; Poncer, JC; Shinozaki, H | 1 |
| Blanc, E; Recasens, M; Vignes, M | 1 |
| Kinney, GA; Slater, NT | 1 |
| Catania, MV; Hollingsworth, Z; Penney, JB; Young, AB | 1 |
| Casabona, G; Genazzani, AA; L'Episcopo, MR; Nicoletti, F; Shinozaki, H | 1 |
| Dykstra, CL; Gebhart, GF; Meller, ST | 1 |
| Bockaert, J; Brabet, I; Curry, K; Gomeza, J; Joly, C; Pin, JP | 1 |
| Lachica, EA; Rubel, EW; Zirpel, L | 1 |
| Bigl, V; Grantyn, R; Rothe, T | 1 |
| Scholz, WK | 1 |
| Akaike, N; Harata, N; Shirasaki, T | 1 |
| McDonald, JW; Schoepp, DD; Wright, RA | 1 |
| Littman, L; Robinson, MB | 1 |
| Rodnight, R; Wofchuk, ST | 1 |
| Cherici, G; Leonard, P; Lombardi, G; Moroni, F; Pellegrini-Giampietro, DE; Pellicciari, R | 1 |
| Lebrun, F; Lerner-Natoli, M; Mayat, E; Réasens, M; Rondouin, G; Sassetti, I | 1 |
| Katz, PS; Levitan, IB | 1 |
| Aronica, E; Balázs, R; Condorelli, DF; Nicoletti, F | 1 |
| Glatt, BS; Littman, L; Robinson, MB | 1 |
| Arrighi, V; Fallacara, C; Memo, M; Pizzi, M; Spano, PF | 1 |
| Masu, M; Nakanishi, S; Takahashi, K; Tanabe, Y; Tsuchida, K | 1 |
| Gähwiler, BH; Gerber, U; Smart, TG; Xie, X | 1 |
| Alesiani, M; Cherici, G; Leonardi, P; Lombardi, G; Moroni, F; Pellicciari, R | 1 |
| Candeo, P; Favaron, M; Gabellini, N; Manev, H; Manev, RM | 1 |
| Baba, A; Hashimoto, H; Saga, H | 1 |
| Birrell, GJ; Marcoux, FW | 1 |
| Childers, WS; Greenough, WT; Weiler, IJ | 1 |
| Chase, LA; Garlin, AB; Johnson, RL; Koerner, JF; Littman, L; Renzi, M; Robinson, MB | 1 |
| Gruol, DL; Netzeband, JG | 1 |
| Choi, S; Lovinger, DM | 1 |
| Neuman, RS; Rahman, S | 1 |
| Kirischuk, S; Kostyuk, P; Verkhratsky, A; Voitenko, N | 1 |
| Flor, PJ; Gomeza, J; Knöpfel, T; Kuhn, R; Pin, JP; Tones, MA | 1 |
| Jane, DE; Roberts, PJ; Toms, NJ; Tse, HW | 1 |
| Nakamura, Y; Ogata, T; Schubert, P | 1 |
| Cai, Z; Rhodes, PG | 2 |
| Burke, JP; Hablitz, JJ | 1 |
| Fu, WM; Liou, HC; Yang, RS | 1 |
| Aleppo, G; Canonico, PL; Casabona, G; Copani, A; Knöpfel, T; Kuhn, R; Malitschek, B; Nicoletti, F; Sortino, MA; Ventra, C | 1 |
| Acuña, C; Cudeiro, J; Martinez-Conde, S; Rivadulla, C; Rodriguez, R | 1 |
| Haak, LL; Heller, HC; van den Pol, AN | 1 |
| Fragoso, G; López-Colomé, AM; Ortega, A; Trueba, E | 1 |
| Belagaje, R; Burnett, JP; Johnson, BG; Mayne, NG; Monn, JA; Salhoff, CR; Schoepp, DD; Wright, RA; Wu, S | 1 |
| Best, R; Boddeke, HW; Boeijinga, PH | 1 |
| Bisso, GM; Fortuna, S; Lorenzini, P; Michalek, H | 1 |
| Balázs, R; Chun, Y; Cotman, CW; de Vries, A; Miller, S; Romano, C | 1 |
| Deng, A; Growdon, JH; Nitsch, RM; Wurtman, RJ | 1 |
| Blue, ME; Brennan, EM; Johnston, MV; Martin, LJ | 1 |
| Keirstead, SA; Miller, RF | 1 |
| Hablitz, JJ; Zhou, FM | 1 |
| Kleinrok, Z; Kocki, T; Saran, T; Turski, WA; Urbanska, EM | 1 |
| Bruno, V; Copani, A; Knöpfel, T; Meltzger, G; Nicoletti, F; Sureda, F | 1 |
| Cardoso, LF; Martini, LH; Ramírez, G; Souza, DO; Tasca, CI | 1 |
| Alger, BE; Kirov, SA; Morishita, W | 1 |
| Challiss, RA; Nahorski, SR; Saunders, R | 1 |
| Chu, Z; Hablitz, JJ | 1 |
| Martin, G; Przewlocki, R; Siggins, GR | 1 |
| Challiss, RA; Hermans, E; Nahorski, SR | 1 |
| Linden, R; Martins, RA; Rocha, M | 1 |
| Bernardi, G; Calabresi, P; Centonze, D; Gubellini, P; Marfia, GA | 1 |
| Blanc, EM; Guiramand, J; Jallageas, M; Recasens, M | 1 |
| Canonico, PL; Copani, A; de Grazia, U; Knöpfel, T; Nicoletti, F; Richelmi, P; Storto, M; Vairetti, M | 1 |
| Krenz, WD; Nguyen, D; Pérez-Acevedo, NL; Selverston, AI | 1 |
| Casabona, G; Copani, A; Di Giorgi Gerevini, V; Mutel, V; Nicoletti, F; Nicosia, A; Romano, C; Storto, M | 1 |
| Alford, S; Schwartz, NE | 1 |
| Ashe, JH; Bandrowski, AE; Crawford, CA | 1 |
| de Almeida, OM; de Mello, FG; de Mello, MC; Gardino, PF; Kubrusly, RC; Loureiro-Dos-Santos, NE; Reis, RA | 1 |
| Chiang, AS; Lin, SC; Liu, HP; Pszczolkowski, MA | 1 |
| Jankovic, SM; Milovanovic, DR | 1 |
| Carmignoto, G; Fellin, T; Gobbo, S; Pozzan, T; Sebelin, A; Zonta, M | 1 |
| Beltramo, M; Brusa, R; Lozza, G; Mancini, I; Petrò, R; Reggiani, A; Scandroglio, P | 1 |
2 review(s) available for 1-amino-1,3-dicarboxycyclopentane and quisqualic acid
| Article | Year |
|---|---|
Metabotropic glutamate receptors: novel targets for drug development.
Topics: Animals; Cloning, Molecular; Drug Design; Humans; Receptors, Metabotropic Glutamate | 1995 |
Ligands for glutamate receptors: design and therapeutic prospects.
Topics: Animals; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ligands; N-Methylaspartate; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synapses | 2000 |
112 other study(ies) available for 1-amino-1,3-dicarboxycyclopentane and quisqualic acid
| Article | Year |
|---|---|
Homology modeling of metabotropic glutamate receptors. (mGluRs) structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Computer Simulation; Electrochemistry; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Conformation; Protein Structure, Secondary; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Sequence Homology | 1996 |
Synthesis and biological activity of glutamic acid derivatives.
Topics: Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Prosencephalon; Rats; Receptors, Metabotropic Glutamate; Synaptosomes | 1998 |
Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation.
Topics: Animals; Binding Sites; Cell Line; CHO Cells; Cricetinae; Glutamates; Ligands; Models, Molecular; Molecular Conformation; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 1999 |
Pharmacophore models of group I and group II metabotropic glutamate receptor agonists. Analysis of conformational, steric, and topological parameters affecting potency and selectivity.
Topics: Excitatory Amino Acid Agonists; Ligands; Molecular Conformation; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 1999 |
Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections.
Topics: Animals; Binding, Competitive; Brain; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Humans; Imidazoles; Indans; Intracellular Fluid; Kainic Acid; Male; Organ Specificity; Quinazolines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Recombinant Proteins; Spinal Cord; Transfection | 2000 |
[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
Topics: Adamantane; Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; Brain; Cell Line; Cell Membrane; CHO Cells; Chromones; Cricetinae; Humans; Naphthalenes; Pyrans; Quinolines; Quinoxalines; Quisqualic Acid; Radioligand Assay; Rats; Receptors, Metabotropic Glutamate; Transfection; Tritium | 2003 |
Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.
Topics: Binding Sites; Databases, Factual; Drug Design; Models, Molecular; Quantitative Structure-Activity Relationship; Receptors, Metabotropic Glutamate; ROC Curve | 2005 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Evidence for metabotropic excitatory amino acid receptor heterogeneity: developmental and brain regional studies.
Topics: Aging; Alanine; Animals; Animals, Newborn; Brain; Cycloleucine; Drug Interactions; Male; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Tissue Distribution | 1992 |
2-Amino-3-phosphonopropionate fails to block postsynaptic effects of metabotropic glutamate receptors in rat hippocampal neurones.
Topics: Action Potentials; Alanine; Animals; Cycloleucine; Female; Glutamates; Hippocampus; Male; Membrane Potentials; Neurons; Neurotoxins; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
Metabotropic glutamate receptor agonists reduce epileptiform activity in the rat cortex.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cycloleucine; Epilepsy; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Quisqualic Acid; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Synapses | 1992 |
Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Alanine; Alkaloids; Animals; Cell Membrane; Cells, Cultured; Colforsin; Corpus Striatum; Cycloleucine; Glutamates; Glutamic Acid; GTP-Binding Proteins; In Vitro Techniques; Mice; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Signal Transduction; Staurosporine; Virulence Factors, Bordetella | 1992 |
Metabotropic glutamate receptor agonists potentiate a slow afterdepolarization in CNS neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cycloleucine; Evoked Potentials; Glutamates; Ibotenic Acid; In Vitro Techniques; Male; Membrane Potentials; Neurons; Prosencephalon; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate | 1992 |
Metabotropic receptor mediated afterdepolarization in neocortical neurons.
Topics: Action Potentials; Animals; Cerebral Cortex; Cycloleucine; Glutamates; Glutamic Acid; In Vitro Techniques; Microelectrodes; Neuromuscular Depolarizing Agents; Neurons; Quisqualic Acid; Rats; Receptors, Glutamate | 1992 |
The expression of presynaptic t-ACPD receptor in rat cerebellum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cerebellum; Cycloleucine; Dendrites; Evoked Potentials; Fluorescent Dyes; Heterocyclic Compounds, 3-Ring; In Vitro Techniques; Membrane Potentials; Neurotoxins; Purkinje Cells; Quinoxalines; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Receptors, Neurotransmitter; Synapses | 1992 |
Metabotropic excitatory amino acid receptor activation stimulates phospholipase D in hippocampal slices.
Topics: Animals; Autoradiography; Cycloleucine; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Hippocampus; Ibotenic Acid; Organ Culture Techniques; Phospholipase D; Quisqualic Acid; Receptors, Amino Acid | 1992 |
Role for ionotropic and metabotropic receptors in quisqualate-stimulated inositol polyphosphate accumulation in rat cerebral cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cerebral Cortex; Cycloleucine; Ibotenic Acid; In Vitro Techniques; Inositol Phosphates; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Neurotransmitter | 1991 |
Metabotropic receptor-mediated regulation of cytoplasmic free calcium in cultured cerebellar granule cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Carbachol; Cells, Cultured; Cerebellum; Cycloleucine; Cytoplasm; Ibotenic Acid; Kinetics; N-Methylaspartate; Neurotoxins; Piperidines; Quisqualic Acid; Receptors, Neurotransmitter | 1991 |
Glutamate mediates a slow synaptic response in hippocampal slice cultures.
Topics: Animals; Cycloleucine; Electric Stimulation; Electrophysiology; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Synapses | 1991 |
Agonists selective for phosphoinositide-coupled receptors sensitize neurons to depolarization by L-2-amino-4-phosphonobutanoic acid (L-AP4).
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Animals; Carbachol; Cerebral Cortex; Cycloleucine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Neuromuscular Depolarizing Agents; Neurons; Norepinephrine; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear | 1991 |
Selective activation of oscillatory currents by trans-ACPD in rat brain mRNA-injected Xenopus oocytes and their blockade by NMDA.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Cycloleucine; Ion Channels; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; RNA, Messenger; Xenopus | 1990 |
The actions of a conformationally restricted analogue of aspartic acid on mammalian spinal neurones.
Topics: Action Potentials; Animals; Aspartic Acid; Cycloleucine; Kainic Acid; Molecular Conformation; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Spinal Cord; Stereoisomerism | 1991 |
Possible heterogeneity of metabotropic glutamate receptors induced in Xenopus oocytes by rat brain mRNA.
Topics: Alanine; Animals; Brain Chemistry; Cycloleucine; GTP-Binding Proteins; Ibotenic Acid; Oocytes; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus | 1991 |
Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Arachidonic Acid; Arachidonic Acids; Aspartic Acid; Cells, Cultured; Corpus Striatum; Cycloleucine; Electrophysiology; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1990 |
The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Ibotenic Acid; Kainic Acid; Magnesium; Membrane Potentials; Neurons; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Potassium conductances in hippocampal neurons blocked by excitatory amino-acid transmitters.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Electric Conductivity; Electrophysiology; Hippocampus; Ibotenic Acid; Kynurenic Acid; Neurons; Potassium Channels; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Muscarinic; Receptors, Neurotransmitter | 1990 |
Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cycloleucine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Excitation of hippocampal neurons by stimulation of glutamate Qp receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Electric Stimulation; Electrophysiology; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Neurons; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Muscarinic; Receptors, Neurotransmitter | 1989 |
Brief calcium transients evoked by glutamate receptor agonists in rat dorsal horn neurons: fast kinetics and mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Female; Glutamates; Glutamic Acid; Ion Channel Gating; Kainic Acid; Kinetics; Lanthanum; N-Methylaspartate; Neurons; Neurotoxins; Photometry; Potassium; Pregnancy; Presynaptic Terminals; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1993 |
Induction of cerebellar long-term depression in culture requires postsynaptic action of sodium ions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Cycloleucine; Electrophysiology; Embryo, Mammalian; Evoked Potentials; Mice; N-Methylaspartate; Neuronal Plasticity; Neurons; Neurotoxins; Picrotoxin; Quisqualic Acid; Receptors, AMPA; Sodium; Synapses; Tetrodotoxin; Veratridine | 1993 |
Ionotropic and metabotropic components of electrophysiological response of cerebellar Purkinje neurons to excitatory amino acids.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Electrophysiology; Neurotoxins; Purkinje Cells; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate | 1993 |
Glutamate-evoked release of arachidonic acid from mouse brain astrocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Astrocytes; Brain; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Cycloleucine; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Neurotoxins; Organ Specificity; Quisqualic Acid; Receptors, Glutamate; Time Factors; Tritium | 1994 |
Metabotropic and ionotropic excitatory amino acid receptor agonists induce different behavioral effects in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ibotenic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Seizures | 1993 |
Metabotropic glutamate receptor modulation of cAMP accumulation in the neonatal rat hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Deaminase; Animals; Animals, Newborn; Colforsin; Cyclic AMP; Cycloleucine; Female; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Neurotoxins; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1993 |
Glutamate receptor-driven activation of transcription factors in primary neuronal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Astrocytes; Base Sequence; Binding Sites; Cell Nucleus; Cell Survival; Cells, Cultured; Cycloleucine; Embryo, Mammalian; Gene Expression; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Mice; Molecular Sequence Data; N-Methylaspartate; Neurons; Proto-Oncogene Proteins; Proto-Oncogenes; Quisqualic Acid; Rats; Receptors, Glutamate; Transcription Factors | 1994 |
Competitive antagonism by phenylglycine derivatives at type I metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Benzoates; Binding, Competitive; Calcium; Cells, Cultured; CHO Cells; Cricetinae; Cycloleucine; Cytidine Diphosphate Diglycerides; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Kainic Acid; Neurons; Neurotoxins; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Quisqualic Acid; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Signal Transduction | 1994 |
A glutamate-activated chloride current in cone-driven ON bipolar cells of the white perch retina.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chloride Channels; Chlorides; Cycloleucine; Dendrites; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurotoxins; Patch-Clamp Techniques; Perches; Picrotoxin; Quinoxalines; Quisqualic Acid; Receptors, Metabotropic Glutamate; Retina; Retinal Cone Photoreceptor Cells; Strychnine | 1995 |
AMPA receptor activation regulates the glutamate metabotropic receptor stimulated phosphatidylinositol turnover in human cerebral cortex slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcimycin; Cerebral Cortex; Child; Cycloleucine; Dizocilpine Maleate; Female; Glutamic Acid; Humans; Male; Middle Aged; N-Methylaspartate; Phosphatidylinositols; Quisqualic Acid; Receptors, AMPA; Receptors, Metabotropic Glutamate; Signal Transduction; Tetrodotoxin | 1995 |
Activation of K+ channels by stimulation of metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cycloleucine; Glutamic Acid; Hippocampus; In Vitro Techniques; Neurons; Potassium Channels; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stimulation, Chemical; Valine | 1995 |
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.
Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line; Chelating Agents; Cycloleucine; Embryo, Mammalian; Fetus; Glioma; Glutamic Acid; Hippocampus; Humans; Indoles; Kidney; Kinetics; Maleimides; N-Methylaspartate; Neuroblastoma; Neurons; Neurotoxins; PC12 Cells; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Protein Kinase C; Protein Processing, Post-Translational; Pyrimidines; Quinacrine; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1995 |
Dual modulation of synaptic inhibition by distinct metabotropic glutamate receptors in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Cycloleucine; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Neurotoxins; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission; Tetrodotoxin | 1995 |
Protein kinase C differently regulates quisqualate- and 1S,3R-trans aminocyclopentane dicarboxylate-induced phosphoinositide hydrolysis during in vitro development of hippocampal neurons.
Topics: Alkaloids; Animals; Carbachol; Cells, Cultured; Cycloleucine; Enzyme Activation; Hippocampus; Hydrolysis; Neurons; Neurotoxins; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Protein Kinase C; Quisqualic Acid; Rats; Staurosporine | 1995 |
Potentiation of NMDA receptor-mediated transmission in turtle cerebellar granule cells by activation of metabotropic glutamate receptors.
Topics: 2-Amino-5-phosphonovalerate; Adenylate Cyclase Toxin; Animals; Cerebellum; Colforsin; Cycloleucine; Evoked Potentials; In Vitro Techniques; Isomerism; Naphthalenes; Nitric Oxide; Pertussis Toxin; Polycyclic Compounds; Purkinje Cells; Quisqualic Acid; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Tetradecanoylphorbol Acetate; Turtles; Virulence Factors, Bordetella | 1993 |
Quisqualate resolves two distinct metabotropic [3H]glutamate binding sites.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Corpus Striatum; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid | 1993 |
(2s,1'R,2'R,3'R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbachol; Cycloleucine; Cyclopropanes; Glycine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1993 |
Acute mechanical hyperalgesia is produced by coactivation of AMPA and metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Hot Temperature; Ibotenic Acid; Male; N-Methylaspartate; Neurotoxins; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Quinoxalines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Spinal Cord | 1993 |
Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Line; Cyclic AMP; Cycloleucine; DNA Primers; Female; Gene Library; Genetic Variation; Glutamic Acid; Ibotenic Acid; In Situ Hybridization; Kidney; Molecular Sequence Data; Neurotoxins; Oocytes; Polymerase Chain Reaction; Prosencephalon; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Restriction Mapping; RNA, Messenger; Spleen; Swine; Transfection; Xenopus | 1995 |
Activation of a metabotropic glutamate receptor increases intracellular calcium concentrations in neurons of the avian cochlear nucleus.
Topics: Animals; Calcium; Chick Embryo; Cochlear Nucleus; Cycloleucine; Glutamic Acid; In Vitro Techniques; Intracellular Membranes; Neurons; Osmolar Concentration; Quisqualic Acid; Receptors, Metabotropic Glutamate | 1995 |
Potentiating and depressant effects of metabotropic glutamate receptor agonists on high-voltage-activated calcium currents in cultured retinal ganglion neurons from postnatal mice.
Topics: Alanine; Aminobutyrates; Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Glutamates; Glutamic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Intracellular Fluid; Mice; omega-Conotoxin GVIA; Organophosphorus Compounds; Peptides; Quisqualic Acid; Receptors, Metabotropic Glutamate; Retinal Ganglion Cells | 1994 |
An ibotenate-selective metabotropic glutamate receptor mediates protein phosphorylation in cultured hippocampal pyramidal neurons.
Topics: Animals; Calcium; Cycloleucine; Diglycerides; Embryo, Mammalian; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol; Inositol Phosphates; Kainic Acid; Myristic Acid; Myristic Acids; N-Methylaspartate; Nerve Tissue Proteins; Neurotoxins; Pertussis Toxin; Phosphatidylcholines; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Protein Kinase C; Pyramidal Cells; Quisqualic Acid; Rats; Receptors, Glutamate; Stearic Acids; Virulence Factors, Bordetella | 1994 |
Metabotropic glutamate response in acutely dissociated hippocampal CA1 pyramidal neurones of the rat.
Topics: Animals; Calcium; Cycloleucine; Dose-Response Relationship, Drug; Electrophysiology; Glutamates; Glutamic Acid; GTP-Binding Proteins; Hippocampus; Intracellular Membranes; Osmolar Concentration; Potassium Channels; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1994 |
Distribution and ontogeny of 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid-sensitive and quisqualate-insensitive [3H]glutamate binding sites in the rat brain.
Topics: Animals; Anions; Brain; Bromides; Calcium; Cell Membrane; Chlorides; Cycloleucine; Female; Glutamates; Glutamic Acid; Hypothalamus; Male; Prosencephalon; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tritium | 1994 |
The effects of L-glutamate and trans-(+-)-1-amino-1,3-cyclopentanedicarboxylate on phosphoinositide hydrolysis can be pharmacologically differentiated.
Topics: Alanine; Animals; Animals, Newborn; Aspartic Acid; Benzoates; Brain; Cerebellum; Cycloleucine; Glutamic Acid; Glycine; Hippocampus; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kinetics; Neurotoxins; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Stereoisomerism | 1994 |
Glutamate stimulates the phosphorylation of glial fibrillary acidic protein in slices of immature rat hippocampus via a metabotropic receptor.
Topics: Animals; Autoradiography; Cycloleucine; Electrophoresis, Gel, Two-Dimensional; Excitatory Amino Acid Agonists; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kinetics; Male; Neurotoxins; Phosphates; Phosphoproteins; Phosphorylation; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1994 |
The depolarization-induced outflow of D-[3H]aspartate from rat brain slices is modulated by metabotropic glutamate receptors.
Topics: Animals; Aspartic Acid; Brain; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Cycloleucine; Gene Expression; In Situ Hybridization; In Vitro Techniques; Kinetics; Male; Neurotoxins; Phosphatidylinositols; Potassium; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; RNA Probes; RNA, Messenger; Transfection | 1994 |
Kainate-induced status epilepticus leads to a delayed increase in various specific glutamate metabotropic receptor responses in the hippocampus.
Topics: Animals; Carbachol; Cycloleucine; Hippocampus; Hydrolysis; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Status Epilepticus; Synaptosomes | 1994 |
Quisqualate and ACPD are agonists for a glutamate-activated current in identified Aplysia neurons.
Topics: Animals; Aplysia; Cells, Cultured; Cycloleucine; Dose-Response Relationship, Drug; Ganglia; Glutamates; Glutamic Acid; Membrane Potentials; Neural Inhibition; Neurons; Potassium Channels; Quisqualic Acid; Receptors, Glutamate; Synaptic Transmission | 1993 |
Pharmacological characterization of metabotropic glutamate receptors in cultured cerebellar granule cells.
Topics: Alanine; Amino Acids, Diamino; Animals; Cells, Cultured; Cerebellum; Cyanobacteria Toxins; Cycloleucine; Drug Interactions; Enzyme Activation; Glutamates; Glutamic Acid; Ibotenic Acid; Magnesium; N-Methylaspartate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Quisqualic Acid; Rats; Receptors, Glutamate | 1993 |
Multiple subtypes of excitatory amino acid receptors coupled to the hydrolysis of phosphoinositides in rat brain.
Topics: Animals; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Cycloleucine; Glutamates; Glutamic Acid; Hippocampus; Hydrolysis; Ibotenic Acid; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, Glutamate | 1993 |
Attenuation of excitatory amino acid toxicity by metabotropic glutamate receptor agonists and aniracetam in primary cultures of cerebellar granule cells.
Topics: Animals; Cell Death; Cells, Cultured; Cerebellum; Cyclic AMP; Cycloleucine; Drug Synergism; Glutamates; Glutamic Acid; Inositol Phosphates; Kainic Acid; Pyrrolidinones; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1993 |
Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination.
Topics: Animals; Cattle; Cycloleucine; Female; Glutamates; Glutamic Acid; Mutagenesis, Site-Directed; Neurotoxins; Oocytes; Quisqualic Acid; Receptors, Glutamate; Recombinant Fusion Proteins; Restriction Mapping; Xenopus | 1993 |
Interaction of zinc with ionotropic and metabotropic glutamate receptors in rat hippocampal slices.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Neurotoxins; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Zinc | 1993 |
Pharmacological characterization of the metabotropic glutamate receptor inhibiting D-[3H]-aspartate output in rat striatum.
Topics: Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Colforsin; Corpus Striatum; Cyclic AMP; Cycloleucine; In Vitro Techniques; Male; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate | 1993 |
Functional evidence for a L-AP3-sensitive metabotropic receptor different from glutamate metabotropic receptor mGluR1.
Topics: Alanine; Animals; Cells, Cultured; Cerebellum; Culture Media; Cycloleucine; Granulocytes; Inositol Phosphates; Neurons; Osmolar Concentration; Potassium Chloride; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; RNA, Messenger | 1993 |
Inhibitory glutamate response on cyclic AMP formation in cultured astrocytes.
Topics: Adenylate Cyclase Toxin; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Colforsin; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; Iodine Radioisotopes; Isoproterenol; Pertussis Toxin; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Virulence Factors, Bordetella | 1993 |
Excitatory amino acid receptor-stimulated phosphoinositide turnover in primary cerebrocortical cultures.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cycloleucine; Female; GTP-Binding Proteins; Kynurenic Acid; Pertussis Toxin; Phosphatidylinositols; Piperazines; Pregnancy; Quinoxalines; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Virulence Factors, Bordetella | 1993 |
Calcium ion impedes translation initiation at the synapse.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cerebral Cortex; Cycloleucine; Depression, Chemical; Gene Expression Regulation; Ionophores; Long-Term Potentiation; N-Methylaspartate; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Protein Biosynthesis; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Ribosomes; RNA, Messenger; Sulfonamides; Synapses | 1996 |
Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; ATP-Binding Cassette Transporters; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Hydrolysis; In Vitro Techniques; Male; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1995 |
Modulatory effects of acute ethanol on metabotropic glutamate responses in cultured Purkinje neurons.
Topics: Animals; Cells, Cultured; Cycloleucine; Ethanol; Purkinje Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1995 |
Metabotropic glutamate receptor modulation of voltage-gated Ca2+ channels involves multiple receptor subtypes in cortical neurons.
Topics: Animals; Benzoates; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Cycloleucine; Cyclopropanes; Electrophysiology; Ethylmaleimide; Excitatory Amino Acid Agonists; Glycine; Ion Channel Gating; Neurons; Neurotoxins; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spider Venoms | 1996 |
Characterization of metabotropic glutamate receptor-mediated facilitation of N-methyl-D-aspartate depolarization of neocortical neurones.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alanine; Alkaloids; Aminobutyrates; Animals; Cerebral Cortex; Cyclic GMP; Cycloleucine; Male; Neurons; Phorbol Esters; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Staurosporine | 1996 |
Calcium signalling in granule neurones studied in cerebellar slices.
Topics: Acetylcholine; Age Factors; Animals; Animals, Newborn; Caffeine; Calcium; Calcium Channel Agonists; Cerebellum; Cycloleucine; Electric Conductivity; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Homeostasis; Ion Channel Gating; Mice; Mice, Inbred CBA; N-Methylaspartate; Neurons; Neurotoxins; Organ Culture Techniques; Phosphodiesterase Inhibitors; Quisqualic Acid; Sensitivity and Specificity; Signal Transduction | 1996 |
The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists.
Topics: Amino Acids, Dicarboxylic; Cell Line; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Humans; Kidney; Neurotoxins; Protein Conformation; Protein Structure, Tertiary; Quisqualic Acid; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Sensitivity and Specificity; Transfection | 1996 |
Characterization of metabotropic glutamate receptor-stimulated phosphoinositide hydrolysis in rat cultured cerebellar granule cells.
Topics: Animals; Cells, Cultured; Cerebellum; Cycloleucine; Excitatory Amino Acid Agonists; Hydrolysis; Neurons; Phosphatidylinositols; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate | 1995 |
Potentiated cAMP rise in metabotropically stimulated rat cultured astrocytes by a Ca2+-related A1/A2 adenosine receptor cooperation.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Astrocytes; Calcium; Cells, Cultured; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Agonists; Purinergic P1 Receptor Agonists; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stimulation, Chemical | 1996 |
Intrauterine hypoxia-ischemia reduces phosphoinositide hydrolysis stimulated by metabotropic glutamate receptor agonists in cultured rat cerebellar granule cells.
Topics: Alanine; Animals; Brain Ischemia; Cell Count; Cells, Cultured; Cerebellum; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Fetal Hypoxia; Hydrolysis; Hypoxia, Brain; Neurons; Neurotoxins; omega-N-Methylarginine; Phosphatidylinositols; Pregnancy; Proteins; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1996 |
G-protein activation by metabotropic glutamate receptors reduces spike frequency adaptation in neocortical neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adult; Alanine; Amino Acids, Dicarboxylic; Animals; Benzoates; Cycloleucine; Enzyme Inhibitors; Frontal Lobe; Glycine; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Isoquinolines; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Protein Kinase Inhibitors; Protein Kinases; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction; Staurosporine; Sulfonamides; Thionucleotides | 1996 |
Potentiation of spontaneous acetylcholine release from motor nerve terminals by glutamate in Xenopus tadpoles.
Topics: Acetylcholine; Alanine; Animals; Calcium; Calcium Channel Blockers; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Larva; Motor Endplate; N-Methylaspartate; Neurotoxins; Quisqualic Acid; Second Messenger Systems; Verapamil; Xenopus laevis | 1996 |
Immortalized hypothalamic neurons express metabotropic glutamate receptors positively coupled to cyclic AMP formation.
Topics: Animals; Cell Division; Cell Line, Transformed; Colforsin; Cyclic AMP; Cycloleucine; Dinoprostone; Excitatory Amino Acid Agonists; Gonadotropin-Releasing Hormone; Hypothalamus; Mice; Neurons; Norepinephrine; Phosphatidylinositols; Quisqualic Acid; Receptors, Metabotropic Glutamate | 1996 |
The influence of nitric oxide on perigeniculate GABAergic cell activity in the anaesthetized cat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Cycloleucine; Enzyme Inhibitors; gamma-Aminobutyric Acid; Geniculate Bodies; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Penicillamine; Photic Stimulation; Quisqualic Acid; S-Nitroso-N-Acetylpenicillamine | 1996 |
Metabotropic glutamate receptor activation modulates kainate and serotonin calcium response in astrocytes.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Astrocytes; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cerebral Cortex; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Nimodipine; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Second Messenger Systems; Serotonin; Suprachiasmatic Nucleus; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1997 |
Excitatory amino acid receptors coupled to the phosphoinositide pathway in Bergmann glia.
Topics: Animals; Astrocytes; Calcium Channels; Cells, Cultured; Cerebellum; Chick Embryo; Cycloleucine; Glutamic Acid; Hydrolysis; Neuroglia; Phosphatidylinositols; Quisqualic Acid; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Stimulation, Chemical | 1997 |
The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors.
Topics: Aging; Animals; Animals, Newborn; Brain; Cloning, Molecular; Colforsin; Cyclic AMP; Cycloleucine; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Humans; Inositol; Kinetics; Neuroprotective Agents; Phosphatidylinositols; Proline; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Resorcinols; Second Messenger Systems | 1996 |
Synchronous 20 Hz rhythmic activity in hippocampal networks induced by activation of metabotropic glutamate receptors in vitro.
Topics: Animals; Bicuculline; Carbachol; Cholinergic Agonists; Cycloleucine; Electroencephalography; Excitatory Amino Acid Agonists; GABA Antagonists; Hippocampus; In Vitro Techniques; Nerve Net; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate | 1997 |
Differential responsiveness of metabotropic glutamate receptors coupled to phosphoinositide hydrolysis to agonists in various brain areas of the adult rat.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Cycloleucine; Dose-Response Relationship, Drug; Hippocampus; Hydrolysis; Ibotenic Acid; In Vitro Techniques; Kinetics; Male; Neuroprotective Agents; Organ Specificity; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1996 |
Metabotropic glutamate receptor mGluR5 in astrocytes: pharmacological properties and agonist regulation.
Topics: Animals; Astrocytes; Calcium; Cells, Cultured; Concanavalin A; Cyclic AMP; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hydrolysis; Inositol Phosphates; Neuroprotective Agents; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sensitivity and Specificity; Tritium | 1997 |
Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain.
Topics: Amyloid beta-Protein Precursor; Benzoates; Cell Line; Cycloleucine; Enzyme Activation; Excitatory Amino Acid Antagonists; Gene Expression; Glutamic Acid; Glycine; GTP-Binding Proteins; Humans; Melitten; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Protein Kinases; Quisqualic Acid; Receptors, Metabotropic Glutamate; Transfection; Type C Phospholipases | 1997 |
Ontogeny of non-NMDA glutamate receptors in rat barrel field cortex: I. Metabotropic receptors.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Cycloleucine; Gene Expression Regulation, Developmental; Glutamic Acid; Immunohistochemistry; Neuroprotective Agents; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Somatosensory Cortex; Tritium; Vibrissae | 1997 |
Metabotropic glutamate receptor agonists evoke calcium waves in isolated Müller cells.
Topics: Adenosine Triphosphate; Ambystoma; Aminobutyrates; Animals; Calcium Channels; Cycloleucine; Excitatory Amino Acid Agonists; Fluorescent Dyes; Histocytochemistry; In Vitro Techniques; Neuroglia; Neuroprotective Agents; Quisqualic Acid; Receptors, Metabotropic Glutamate; Retina | 1997 |
Metabotropic glutamate receptor enhancement of spontaneous IPSCs in neocortical interneurons.
Topics: Action Potentials; Animals; Cell Polarity; Chlorides; Cycloleucine; Evoked Potentials; Frontal Lobe; In Vitro Techniques; Interneurons; Neocortex; Patch-Clamp Techniques; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrodotoxin | 1997 |
Impairment of brain kynurenic acid production by glutamate metabotropic receptor agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Cycloleucine; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Sodium | 1997 |
Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes.
Topics: Animals; Cells, Cultured; Cycloleucine; Excitatory Amino Acid Agonists; Liver; Neuroprotective Agents; Phosphatidylinositol Phosphates; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate | 1997 |
Guanine nucleotides inhibit cAMP accumulation induced by metabotropic glutamate receptor activation.
Topics: Animals; Cyclic AMP; Cycloleucine; Glutamic Acid; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Monophosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hippocampus; Neurotoxins; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Thionucleotides | 1998 |
Prenatal ethanol exposure enhances glutamate release stimulated by quisqualate in rat cerebellar granule cell cultures.
Topics: Alcoholism; Amino Acids; Animals; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Ethanol; Female; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Potassium Chloride; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1998 |
Evidence for metabotropic glutamate receptor activation in the induction of depolarization-induced suppression of inhibition in hippocampal CA1.
Topics: 4-Aminopyridine; Amino Acids, Dicarboxylic; Animals; Benzoates; Calcium Channels; Cycloleucine; Cyclopropanes; Enzyme Inhibitors; Ethylmaleimide; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Male; Membrane Potentials; Neural Inhibition; Neuroprotective Agents; Patch-Clamp Techniques; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Signal Transduction; Synapses | 1998 |
A modulatory effect of extracellular Ca2+ on type 1alpha metabotropic glutamate receptor-mediated signalling.
Topics: Animals; Arecoline; Calcium; Cell Line; Cricetinae; Cycloleucine; Enzyme Activation; Excitatory Amino Acid Agonists; Inositol Phosphates; Kidney; Methacholine Chloride; Muscarinic Agonists; Quisqualic Acid; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Type C Phospholipases | 1998 |
Activation of group I mGluRs increases spontaneous IPSC frequency in rat frontal cortex.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Frontal Lobe; Glycine; Neural Inhibition; Neuroprotective Agents; Patch-Clamp Techniques; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Synaptic Transmission; Tetrodotoxin | 1998 |
Chronic morphine treatment selectively augments metabotropic glutamate receptor-induced inhibition of N-methyl-D-aspartate receptor-mediated neurotransmission in nucleus accumbens.
Topics: Analgesics, Opioid; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Morphine; Neuroprotective Agents; Nucleus Accumbens; Propionates; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Effects of varying the expression level of recombinant human mGlu1alpha receptors on the pharmacological properties of agonists and antagonists.
Topics: Animals; CHO Cells; Cricetinae; Cycloleucine; Humans; Immunohistochemistry; Inositol Phosphates; Isopropyl Thiogalactoside; Pyruvic Acid; Quisqualic Acid; Receptors, Metabotropic Glutamate; Recombinant Proteins | 1999 |
Activation of NMDA receptors protects against glutamate neurotoxicity in the retina: evidence for the involvement of neurotrophins.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Growth Factors; Neuroprotective Agents; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptors, N-Methyl-D-Aspartate; Receptors, Nerve Growth Factor; Retina | 1999 |
Glutamate-triggered events inducing corticostriatal long-term depression.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Cycloleucine; Electric Stimulation; Electrophysiology; Glutamic Acid; Hydroxylamine; In Vitro Techniques; Male; Membrane Potentials; Neuronal Plasticity; Neurons; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Sulpiride; Synaptic Transmission; Time Factors | 1999 |
Potentiation of glutamatergic agonist-induced inositol phosphate formation by basic fibroblast growth factor is related to developmental features in hippocampal cultures: neuronal survival and glial cell proliferation.
Topics: Animals; Antimetabolites, Antineoplastic; Benzoates; Cell Division; Cell Survival; Cells, Cultured; Cellular Senescence; Cycloleucine; Cytarabine; Epidermal Growth Factor; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Fibroblast Growth Factor 2; Glutamic Acid; Glycine; Hippocampus; Inositol Phosphates; Neuroglia; Neurons; Neuroprotective Agents; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Type C Phospholipases | 1999 |
Selective blockade of mGlu5 metabotropic glutamate receptors protects rat hepatocytes against hypoxic damage.
Topics: Animals; Animals, Newborn; Blotting, Western; Cell Hypoxia; Cells, Cultured; Cycloleucine; Excitatory Amino Acid Agonists; Glycine; Immunohistochemistry; Liver; Male; Neuroprotective Agents; Pyridines; Quisqualic Acid; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2000 |
Group I, II, and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion.
Topics: Alanine; Amino Acids, Dicarboxylic; Animals; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Ganglia, Invertebrate; In Vitro Techniques; Male; Methoxyhydroxyphenylglycol; Motor Neurons; Nephropidae; Nerve Net; Quisqualic Acid; Receptors, Metabotropic Glutamate; Stomach | 2000 |
Reducing conditions differentially affect the functional and structural properties of group-I and -II metabotropic glutamate receptors.
Topics: Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Carbachol; Cell Membrane; Cerebellum; CHO Cells; Cholinergic Agonists; Colforsin; Cricetinae; Cyclic AMP; Cycloleucine; Cyclopropanes; Dimerization; Dithiothreitol; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Humans; Kidney; Neurons; Neuroprotective Agents; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Signal Transduction | 2000 |
Physiological activation of presynaptic metabotropic glutamate receptors increases intracellular calcium and glutamate release.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Brain Stem; Calcium; Chromones; Cycloleucine; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorometry; Glutamic Acid; Glycine Agents; GTP-Binding Proteins; In Vitro Techniques; Lampreys; Larva; Membrane Potentials; N-Methylaspartate; Neuronal Plasticity; Neuroprotective Agents; Patch-Clamp Techniques; Presynaptic Terminals; Quisqualic Acid; Receptors, Metabotropic Glutamate; Strychnine; Tetrodotoxin | 2000 |
Tetanic stimulation and metabotropic glutamate receptor agonists modify synaptic responses and protein kinase activity in rat auditory cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Auditory Cortex; Cyclic AMP-Dependent Protein Kinases; Cycloleucine; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Long-Term Potentiation; Male; Naphthalenes; Neural Inhibition; Neurons; Neuroprotective Agents; Phosphorylation; Protein Kinase C; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2001 |
Inhibition of choline acetyltransferase by excitatory amino acids as a possible mechanism for cholinergic dysfunction in the central nervous system.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Chick Embryo; Choline O-Acetyltransferase; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Neurons; NG-Nitroarginine Methyl Ester; Propionates; Quisqualic Acid; Retina; Signal Transduction; Tetrodotoxin; Trifluoperazine; Verapamil | 2001 |
Ionotropic glutamate receptors mediate juvenile hormone synthesis in the cockroach, Diploptera punctata.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cockroaches; Corpora Allata; Cycloleucine; Cytosol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Juvenile Hormones; Kainic Acid; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Receptors, Metabotropic Glutamate | 2002 |
A pharmacological analysis of the contractile effects of glutamate on rat and human isolated gut smooth muscle strips.
Topics: Aged; Animals; Aspartic Acid; Cycloleucine; Evoked Potentials, Motor; Female; Gastric Fundus; Glutamic Acid; Humans; In Vitro Techniques; Intestine, Large; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Proline; Quisqualic Acid; Rats; Receptors, Glutamate; Rectum; Stomach | 2002 |
Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes.
Topics: Animals; Astrocytes; Calcium; Calcium Signaling; Cell Line; Cells, Cultured; Coculture Techniques; Cycloleucine; Cytosol; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Epithelial Cells; Glutamic Acid; Green Fluorescent Proteins; Humans; Indomethacin; Luminescent Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Patch-Clamp Techniques; Prostaglandins; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Transfection; Valine; Xanthones | 2003 |
Evaluation of cannabinoid receptor 2 and metabotropic glutamate receptor 1 functional responses using a cell impedance-based technology.
Topics: Analgesics; Animals; Benzimidazoles; Biological Assay; Calcium; Cannabinoids; CHO Cells; Chromones; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Cycloleucine; Electric Impedance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Indoles; Naphthalenes; Neuroprotective Agents; Quinolines; Quisqualic Acid; Receptor, Cannabinoid, CB2; Receptors, Metabotropic Glutamate; Resorcinols; Signal Transduction; Thiazoles | 2010 |