1-amino-1,3-dicarboxycyclopentane has been researched along with n-methylaspartate in 177 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.56) | 18.7374 |
| 1990's | 151 (85.31) | 18.2507 |
| 2000's | 23 (12.99) | 29.6817 |
| 2010's | 2 (1.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Araldi, GL; Kozikowski, AP; Pshenichkin, S; Steensma, D; Surina, E; Tückmantel, W; Wang, S; Wroblewski, JT | 1 |
| Bräuner-Osborne, H; Egebjerg, J; Krogsgaard-Larsen, P; Madsen, U; Nielsen, EO | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Cerne, R; Randic, M | 1 |
| Hong, JS; McMillian, M; Pennypacker, KR | 1 |
| Alexander, SP; Curtis, AR; Hill, SJ; Kendall, DA | 1 |
| Haley, JE; Kitto, KF; Wilcox, GL | 1 |
| Aleppo, G; Aronica, E; Bruno, V; Canonico, PL; Copani, A; D'Agata, V; Nicoletti, F; Pisani, A | 1 |
| Radpour, S; Thomson, AM | 1 |
| Clifford, DB; Izumi, Y; Zorumski, CF | 1 |
| Bleakman, D; Chard, PS; Glaum, SR; Miller, RJ; Rusin, KI | 1 |
| McDonald, JW; Schoepp, DD | 1 |
| Fadda, E; Lipartiti, M; Manev, H; Sautter, J; Siliprandi, R | 1 |
| Lowe, DA; Roy, BL; Taschenberger, H | 1 |
| Courtney, MJ; Nicholls, DG | 1 |
| Cotman, CW; Koh, JY; Palmer, E | 1 |
| Cotman, CW; Koh, JY; Lin, A; Palmer, E | 1 |
| Lanthorn, TH; Monaghan, DT; Watson, GB | 1 |
| Aniksztejn, L; Ben-Ari, Y; Bregestovski, P | 1 |
| Corden, M; Curry, K; McLennan, H | 1 |
| Bockaert, J; Dumuis, A; Oomagari, K; Pin, JP; Sebben, M | 1 |
| Cotman, CW; Monaghan, DT; Palmer, E | 1 |
| MacDermott, AB; Reichling, DB | 1 |
| Connor, JA; Linden, DJ; Smeyne, M | 1 |
| Miller, RF; Thoreson, WB | 1 |
| Glowinski, J; Prémont, J; Stella, N; Tencé, M | 1 |
| Klitgaard, H; Laudrup, P | 2 |
| Battaglia, G; Bruno, V; Copani, A; Nicoletti, F; Raffaele, R; Shinozaki, H | 1 |
| Argiolas, A; Melis, MR; Stancampiano, R | 1 |
| Herrera, AJ; Osborne, NN | 1 |
| Amico, C; Condorelli, DF; Dell'Albani, P; Giuffrida-Stella, AM; Kaczmarek, L; Lukasiuk, K | 1 |
| Mikuni, M; Saitoh, K; Shinno, H; Takahashi, K; Tomita, U; Yamawaki, S | 1 |
| Lücke, T; Neugebauer, V; Schaible, HG | 1 |
| Gebhart, GF; Meller, ST | 1 |
| Abe, I; Fujishima, M; Tsuchihashi, T | 1 |
| Collins, DR; Davies, SN | 1 |
| Devillers, JP; Simonnet, G | 1 |
| Dowling, JE; Grant, GB | 1 |
| Acciarri, N; Beani, L; Bianchi, C; Calo, G; Fabrizi, A; Ferraro, L; Morari, M; Piazza, G | 1 |
| McCarthy, KD; Porter, JT | 1 |
| Gorman, AM; Grieve, A; Griffiths, R | 1 |
| Cotman, CW; Kesslak, JP; Miller, S; Romano, C | 1 |
| de Mello, FG; de Mello, MC; Kubrusly, RC; Reis, RA | 1 |
| Cox, AJ; Lee, RK; Nitsch, RM; Wurtman, RJ | 1 |
| Birse, EF; Eaton, SA; Jane, DE; Jones, PL; Pook, PC; Porter, RH; Roberts, PJ; Sunter, DC; Udvarhelyi, PM; Wharton, B | 1 |
| Alagarsamy, S; Johnson, KM; Lonart, G | 1 |
| Catania, MV; Hollingsworth, Z; Penney, JB; Young, AB | 1 |
| Bockaert, J; Cragoe, EJ; Dumuis, A; Fagni, L; Manzoni, O; Prézeau, L; Sebben, M | 1 |
| Jane, DE; Jones, PL; Pook, PC; Salt, TE; Sunter, DC; Watkins, JC | 1 |
| Naarala, J; Nykvist, P; Savolainen, K; Tuomala, M | 1 |
| Dykstra, CL; Gebhart, GF; Meller, ST | 1 |
| Klockgether, T; Turski, L | 1 |
| Ambrosini, A; Bresciani, L; Brunello, N; Fracchia, S; Racagni, G | 1 |
| Challiss, RA; Mistry, R; Wilke, R | 1 |
| Birrell, GJ; Gordon, MP; Marcoux, FW | 1 |
| Scholz, WK | 1 |
| Esposito, E; Gorbunov, N | 1 |
| Challiss, RA; Gray, DW; Mistry, R; Nahorski, SR | 1 |
| Jane, DE; Jones, PL; Pook, PC; Tse, HW; Watkins, JC | 1 |
| Hansen, L; Suzdak, PD; Thomsen, C | 1 |
| Colwell, CS; Levine, MS | 2 |
| Alford, S; Dubuc, R | 1 |
| Aronica, E; Balázs, R; Condorelli, DF; Nicoletti, F | 1 |
| Beani, L; Bianchi, C; Caló, G; Ferraro, L; Menegale, M; Morari, M; Tomasini, C | 1 |
| Andersen, CF; Frandsen, A; Schousboe, A; Suzdak, PD; Thomsen, C | 1 |
| Eaton, SA; Jane, DE; Jones, PL; Pook, PC; Porter, RH; Roberts, PJ; Salt, TE; Sunter, DC; Udvarhelyi, PM; Watkins, JC | 1 |
| Ballyk, BA; Goh, JW; Musgrave, MA | 1 |
| Collingridge, GL; Harvey, J | 1 |
| Ishida, M; Ohfune, Y; Saitoh, T; Shimamoto, K; Shinozaki, H | 1 |
| Arban, R; Fadda, E; Lipartiti, M; Manev, H; Sautter, J; Savoini, G; Siliprandi, R | 1 |
| Behnisch, T; Reymann, KG | 1 |
| De Bernardi, R; Ferro, F; Fontana, G; Gemignani, A; Raiteri, M | 1 |
| Childers, WS; Greenough, WT; Weiler, IJ | 1 |
| Bond, A; Lodge, D | 1 |
| Carter, AJ; Kozikowski, AP; Opitz, T; Reymann, KG; Richter, P; Shinozaki, H | 1 |
| Morishita, W; Sastry, BR; Shew, TR | 1 |
| Cao, CQ; Evans, RH; Headley, PM; Udvarhelyi, PM | 1 |
| Berrino, L; Leyva, J; Maione, S; Pallotta, M; Rossi, F | 1 |
| Ohno, M; Watanabe, S | 1 |
| Kirischuk, S; Kostyuk, P; Verkhratsky, A; Voitenko, N | 1 |
| Challiss, RA; Nahorski, SR; Simpson, PB | 1 |
| Berrino, L; D'Amico, M; de Novellis, V; Pizzirusso, A; Rossi, F | 1 |
| Bruno, V; Marinozzi, M; Nicoletti, F; Pellicciari, R; Thomsen, C | 1 |
| Kaneko, A; Sasaki, T | 1 |
| Clements, MP; Rose, SP | 1 |
| Consolandi, O; Memo, M; Pizzi, M; Spano, PF | 1 |
| Barrios, M; Liljequist, S | 1 |
| Carlà, V; Mannaioni, G; Moroni, F | 1 |
| Altemus, KL; Colwell, CS; Levine, MS | 1 |
| Daw, NW; Wang, XF | 1 |
| Koenig, ML; Meyerhoff, JL; Yourick, DL | 1 |
| Arnolda, LF; Chalmers, JP; Llewellyn-Smith, IJ; Minson, JB; Pilowsky, PM | 1 |
| Burke, JP; Hablitz, JJ | 1 |
| Fu, WM; Liou, HC; Yang, RS | 1 |
| Chisamore, B; Dow, K; Solc, M | 1 |
| Acuña, C; Cudeiro, J; Martinez-Conde, S; Rivadulla, C; Rodriguez, R | 1 |
| Angenstein, F; Hirschfelder, M; Staak, S | 1 |
| Easaw, JC; Jhamandas, JH; Petrov, T | 1 |
| Bhardwaj, A; Hanley, DF; Koehler, RC; Martin, LJ; Northington, FJ; Traystman, RJ | 1 |
| Alici, K; Gloveli, T; Heinemann, U; Schmitz, D | 1 |
| Rusak, B; Scott, G | 1 |
| Abe, I; Fujishima, M; Kagiyama, S; Onaka, U; Tsuchihashi, T | 1 |
| Dow, KE; Wang, W | 1 |
| Gähwiler, BH; Gerber, U; Lüthi, A | 2 |
| Jane, DE; Thomas, NK; Tse, HW; Watkins, JC | 1 |
| Bernardi, G; Calabresi, P; Centonze, D; Pisani, A | 1 |
| Fergus, A; Lee, KS | 1 |
| Clapp, LE; DeCoster, MA; Klette, KL; Lin, Y; Moreton, JE; Tortella, FC | 1 |
| Argiolas, A; Iannucci, U; Melis, MR; Succu, S | 1 |
| Nabeshima, T; Yamada, K | 1 |
| Blasi, F; Guerrini, L; Kistler, B; Molteni, A; Wirth, T | 1 |
| Komori, Y; Nabeshima, T; Nikai, T; Senzaki, K; Sugihara, H; Yamada, K | 1 |
| Mifflin, SW; Zhang, J | 1 |
| Bordi, F; Corsi, M; Ugolini, A | 2 |
| Kleinrok, Z; Kocki, T; Saran, T; Turski, WA; Urbanska, EM | 1 |
| Clayton, P; Jane, DE; Thomas, NK | 1 |
| Budai, D; Larson, AA | 1 |
| Baird, DH; Console-Bram, LM; Fitzpatrick-McElligott, SG; McElligott, JG | 1 |
| Baruzzi, F; Memo, M; Paterlini, M; Spano, PF; Valerio, A | 1 |
| Durkin, JP; Mealing, GA; Morley, P; Murray, CL; Poulter, MO; Small, DL; Stanimirovic, DB | 1 |
| Cudeiro, J; Grieve, KL; Rivadulla, C | 1 |
| Cai, Z; Rhodes, PG | 1 |
| González, MP; Herrero, MT; Oset-Gasque, MJ; Vicente, S | 1 |
| Salt, TE; Turner, JP | 1 |
| McGee, J; Sanes, DH; Walsh, EJ | 1 |
| Schwarzer, C; Sperk, G | 1 |
| Daw, NW; Jin, X | 1 |
| López, T; López-Colomé, AM; Ortega, A | 1 |
| Sattler, R; Spetzler, RF; Tymianski, M; Zabramski, JM | 1 |
| Näsström, J; Sequeira, S | 1 |
| Murali, SG; Sun, D | 1 |
| Chandler, SH; Del Negro, CA | 1 |
| Daw, NW; Jin, X; Wang, XF | 1 |
| El Manira, A; Grillner, S; Krieger, P | 1 |
| Banno, T; Kohno, K | 1 |
| Davidoff, RA; Hackman, JC; Holohean, AM | 1 |
| Bockaert, J; Fagni, L; Guiraud, MJ; Lafon-Cazal, M; Lerner-Natoli, M; Mary, S; Pin, JP; Shigemoto, R | 1 |
| Irić-Cupić, V; Janković, SM; Matović, M; Milovanović, D | 1 |
| Bhatnagar, T; Chitravanshi, VC; Sapru, HN | 1 |
| Foley, CM; Hasser, EM; Hay, M; Mueller, PJ; Vogl, HW | 1 |
| Linden, R; Martins, RA; Rocha, M | 1 |
| Alagarsamy, S; Conn, PJ; Gereau, RW; Heinemann, SF; Rouse, ST; Smith, Y | 1 |
| Al-Ghoul, W; Curras, MC; Meeker, RB; Serje, A; Stewart, J | 1 |
| Chen, Q; Reiner, A; Surmeier, DJ | 1 |
| Dammerman, RS; Flint, AC; Kriegstein, AR | 1 |
| Kingston, AE; Salt, TE; Turner, JP | 1 |
| Hanania, T; Johnson, KM | 1 |
| Chouvet, G; Dugast, C; Schmitt, P; Souliere, F | 1 |
| Bardgett, ME; Henry, JD | 1 |
| Ellis, EF; Moore, SF; Rzigalinski, BA; Weber, JT; Willoughby, KA | 1 |
| Benarese, M; Boroni, F; Goffi, F; Pizzi, M; Spano, PF; Valerio, A | 1 |
| Alford, S; Schwartz, NE | 1 |
| Adamchik, Y; Baskys, A | 1 |
| Inoue, N; Nakayama, T; Soga, TM | 1 |
| Blaabjerg, M; Bonde, C; Kristensen, BW; Zimmer, J | 1 |
| Bennett, MV; Jover, T; Lan , JY; Skeberdis, VA; Zheng, X; Zukin, RS | 1 |
| Abe, I; Fujishima, M; Kagiyama, S; Matsumura, K; Phillips, MI; Tsuchihashi, T | 1 |
| Abarca, J; Bustos, G; Campusano, JM; Forray, MI; Gysling, K | 1 |
| Meeker, RB | 1 |
| Johnson, SW; Zheng, F | 1 |
| Boldyrev, AA; Bulygina, ER; Lyapina, LY | 1 |
| Chan, JY; Lo, WC; Tseng, CJ; Tung, CS | 1 |
| Brown, JJ; Bushman, SM; Pszczolkowski, MA; Zahand, A | 1 |
| Boldyrev, A; Bulygina, E; Gerasimova, O | 1 |
| Sitniewska, EM; Wiśniewska, RJ; Wiśniewski, K | 1 |
| Kudo, Y; Matsumoto, N; Miyakawa, H; Morita, M; Tsuchiya, R; Yoshida, Y | 1 |
| Chianca, DA; Dragon, DN; Lin, LH; Talman, WT | 1 |
| Boeck, CR; Bronzatto, MJ; Jardim, FM; Kroth, EH; Souza, DO; Vendite, D | 1 |
| Calixto, JB; Gadotti, VM; Paszcuk, AF; Rodrigues, AL; Santos, AR; Tibola, D | 1 |
| Andrianov, GN; Nozdrachev, AD; Ryzhova, IV | 1 |
| Jakovljevic, M; Jankovic, SM; Jankovic, SV; Milovanovic, D; Stojadinovic, D | 1 |
| Chen, Y; Ma, Y; McNearney, TA; Taglialatela, G; Westlund, KN; Yin, H; Zhang, WR | 1 |
| Baldridge, WH; Blandford, SN | 1 |
2 review(s) available for 1-amino-1,3-dicarboxycyclopentane and n-methylaspartate
| Article | Year |
|---|---|
Ligands for glutamate receptors: design and therapeutic prospects.
Topics: Animals; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ligands; N-Methylaspartate; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synapses | 2000 |
Roles of metabotropic glutamate receptors in brain plasticity and pathology.
Topics: Animals; Astrocytes; Brain; Brain Diseases; Carbachol; Cells, Cultured; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; In Vitro Techniques; Mice; N-Methylaspartate; Neuronal Plasticity; Phosphatidylinositols; Receptors, Metabotropic Glutamate; Signal Transduction | 1995 |
175 other study(ies) available for 1-amino-1,3-dicarboxycyclopentane and n-methylaspartate
| Article | Year |
|---|---|
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.
Topics: Animals; Bridged Bicyclo Compounds; Calcium; Cells, Cultured; Cerebellum; CHO Cells; Cricetinae; Cyclic AMP; Cycloleucine; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Glutamic Acid; Inositol Phosphates; Kidney; Ligands; Models, Molecular; Molecular Conformation; Norbornanes; Rats; Receptors, Metabotropic Glutamate; Stereoisomerism | 1998 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Modulation of AMPA and NMDA responses in rat spinal dorsal horn neurons by trans-1-aminocyclopentane-1,3-dicarboxylic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Electrophysiology; Ibotenic Acid; N-Methylaspartate; Neurons; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Spinal Cord | 1992 |
Preferential activation of [3H]phorbol-12,13-dibutyrate binding by AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) in neonatal striatal cell cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Binding Sites; Cells, Cultured; Corpus Striatum; Cycloleucine; Glial Fibrillary Acidic Protein; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Phorbol 12,13-Dibutyrate; Phosphopyruvate Hydratase; Rats; Rats, Inbred F344 | 1992 |
Activation of a metabotropic excitatory amino acid receptor potentiates A2b adenosine receptor-stimulated cyclic AMP accumulation.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biotransformation; Cerebral Cortex; Cyclic AMP; Cycloleucine; Female; Guinea Pigs; Ibotenic Acid; In Vitro Techniques; Inositol Phosphates; Male; N-Methylaspartate; Receptors, Amino Acid; Receptors, Purinergic; Vasodilator Agents | 1992 |
Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Arginine; Cycloleucine; Hemoglobins; Hydroxylamine; Hydroxylamines; Hyperalgesia; Ibotenic Acid; Injections, Spinal; Kainic Acid; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Spinal Cord; Time Factors | 1992 |
Metabotropic glutamate receptors and neuronal toxicity.
Topics: Amino Acids, Diamino; Animals; Cells, Cultured; Cerebellum; Cyanobacteria Toxins; Cycloleucine; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1992 |
Synaptic enhancement induced by NMDA and Qp receptors and presynaptic activity.
Topics: Animals; Axons; Cycloleucine; Electrophysiology; Evoked Potentials; Hippocampus; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurotoxins; Oxadiazoles; Pyramidal Tracts; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1992 |
Norepinephrine reverses N-methyl-D-aspartate-mediated inhibition of long-term potentiation in rat hippocampal slices.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cycloleucine; Hippocampus; In Vitro Techniques; Isoproterenol; Male; Methoxamine; N-Methylaspartate; Neuronal Plasticity; Norepinephrine; Phenylephrine; Rats | 1992 |
Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Drug Synergism; Glutamates; Glutamic Acid; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Myocardial Contraction; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synapses; Synaptic Transmission | 1992 |
The metabotropic excitatory amino acid receptor agonist 1S,3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cycloleucine; Drug Synergism; Ibotenic Acid; In Vitro Techniques; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid | 1992 |
Activation of the glutamate metabotropic receptor protects retina against N-methyl-D-aspartate toxicity.
Topics: Animals; Cycloleucine; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glutamate; Retina | 1992 |
Effects of a metabotropic glutamate agonist, trans-ACPD, on cortical epileptiform activity.
Topics: Animals; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Epilepsy; Glutamates; In Vitro Techniques; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Stereoisomerism | 1992 |
Metabotropic receptor-mediated regulation of cytoplasmic free calcium in cultured cerebellar granule cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Carbachol; Cells, Cultured; Cerebellum; Cycloleucine; Cytoplasm; Ibotenic Acid; Kinetics; N-Methylaspartate; Neurotoxins; Piperidines; Quisqualic Acid; Receptors, Neurotransmitter | 1991 |
Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Animals; Carbachol; Cells, Cultured; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Isoquinolines; Mice; N-Methylaspartate; Neurons; Neurotoxins; Piperazines; Protein Kinase C; Receptors, Glutamate; Receptors, Neurotransmitter; Sulfonamides | 1991 |
A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebral Cortex; Cycloleucine; Embryo, Mammalian; Glutamates; Ibotenic Acid; Kainic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Receptors, Glutamate; Receptors, Neurotransmitter; Tetrodotoxin | 1991 |
Selective activation of oscillatory currents by trans-ACPD in rat brain mRNA-injected Xenopus oocytes and their blockade by NMDA.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Cycloleucine; Ion Channels; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; RNA, Messenger; Xenopus | 1990 |
Selective activation of quisqualate metabotropic receptor potentiates NMDA but not AMPA responses.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Ion Channels; N-Methylaspartate; Neurons; Receptors, AMPA; Receptors, Neurotransmitter | 1991 |
The actions of a conformationally restricted analogue of aspartic acid on mammalian spinal neurones.
Topics: Action Potentials; Animals; Aspartic Acid; Cycloleucine; Kainic Acid; Molecular Conformation; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Spinal Cord; Stereoisomerism | 1991 |
Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Arachidonic Acid; Arachidonic Acids; Aspartic Acid; Cells, Cultured; Corpus Striatum; Cycloleucine; Electrophysiology; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1990 |
Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cycloleucine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Brief calcium transients evoked by glutamate receptor agonists in rat dorsal horn neurons: fast kinetics and mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Female; Glutamates; Glutamic Acid; Ion Channel Gating; Kainic Acid; Kinetics; Lanthanum; N-Methylaspartate; Neurons; Neurotoxins; Photometry; Potassium; Pregnancy; Presynaptic Terminals; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1993 |
Induction of cerebellar long-term depression in culture requires postsynaptic action of sodium ions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Cycloleucine; Electrophysiology; Embryo, Mammalian; Evoked Potentials; Mice; N-Methylaspartate; Neuronal Plasticity; Neurons; Neurotoxins; Picrotoxin; Quisqualic Acid; Receptors, AMPA; Sodium; Synapses; Tetrodotoxin; Veratridine | 1993 |
Membrane currents evoked by excitatory amino acid agonists in ON bipolar cells of the mudpuppy retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Animals; Cadmium; Cell Membrane; Cobalt; Cycloleucine; Electrophysiology; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Necturus maculosus; Neurotransmitter Agents; Receptors, Amino Acid; Retina | 1993 |
Glutamate-evoked release of arachidonic acid from mouse brain astrocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Astrocytes; Brain; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Cycloleucine; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Neurotoxins; Organ Specificity; Quisqualic Acid; Receptors, Glutamate; Time Factors; Tritium | 1994 |
Metabotropic and ionotropic excitatory amino acid receptor agonists induce different behavioral effects in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ibotenic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Seizures | 1993 |
Metabotropic excitatory amino acid receptor agonists selectively potentiate behavioral effects induced by ionotropic excitatory amino acid receptor agonists in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; Drug Synergism; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Neurotoxins; Pentylenetetrazole; Receptors, Glutamate; Seizures | 1993 |
Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acids, Dicarboxylic; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cycloleucine; Cyclopropanes; Glycine; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Phosphatidylinositols; Receptors, Metabotropic Glutamate | 1994 |
Penile erection and yawning induced by paraventricular NMDA injection in male rats are mediated by oxytocin.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dopamine; Injections; Injections, Intraventricular; Male; N-Methylaspartate; Neurotoxins; Oxytocin; Paraventricular Hypothalamic Nucleus; Penile Erection; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Synaptic Transmission; Yawning | 1994 |
The effect of experimental ischaemia and excitatory amino acid agonists on the GABA and serotonin immunoreactivities in the rabbit retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cycloleucine; Dextromethorphan; Eye Proteins; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamic Acid; Intraocular Pressure; Ischemia; Kainic Acid; Kynurenic Acid; Memantine; N-Methylaspartate; Oxygen; Potassium Cyanide; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Vessels; Serotonin | 1994 |
Glutamate receptor-driven activation of transcription factors in primary neuronal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Astrocytes; Base Sequence; Binding Sites; Cell Nucleus; Cell Survival; Cells, Cultured; Cycloleucine; Embryo, Mammalian; Gene Expression; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Mice; Molecular Sequence Data; N-Methylaspartate; Neurons; Proto-Oncogene Proteins; Proto-Oncogenes; Quisqualic Acid; Rats; Receptors, Glutamate; Transcription Factors | 1994 |
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine Maleate; Glioma; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Ion Channels; Kainic Acid; Kinetics; Magnesium Chloride; N-Methylaspartate; Neurotoxins; Pyrrolidinones; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Signal Transduction; Tumor Cells, Cultured | 1994 |
Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons.
Topics: Acute Disease; Afferent Pathways; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arthritis; Cycloleucine; Inflammation; Knee Joint; Male; N-Methylaspartate; Neurons; Pain; Pressure; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1994 |
Spinal mediators of hyperalgesia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Arginine; Calcium; Cycloleucine; Disease Models, Animal; Excitatory Amino Acids; Hot Temperature; Hyperalgesia; Male; N-Methylaspartate; Neuronal Plasticity; Neurons, Afferent; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stress, Mechanical | 1994 |
Role of metabotropic glutamate receptors in ventrolateral medulla of hypertensive rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Cycloleucine; Heart Rate; Hypertension; Male; Medulla Oblongata; N-Methylaspartate; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Metabotropic Glutamate; Sympathetic Nervous System | 1994 |
Potentiation of synaptic transmission in the rat hippocampal slice by exogenous L-glutamate and selective L-glutamate receptor subtype agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Evoked Potentials; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hippocampus; In Vitro Techniques; Iontophoresis; N-Methylaspartate; Nerve Fibers; Neurotoxins; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Synapses; Synaptic Transmission | 1994 |
Modulation of neuropeptide FF release from rat spinal cord slices by glutamate. Involvement of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dizocilpine Maleate; Glutamic Acid; In Vitro Techniques; Iodine Radioisotopes; Male; Membranes; N-Methylaspartate; Neuropeptides; Neurotoxins; Oligopeptides; Radioimmunoassay; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1994 |
A glutamate-activated chloride current in cone-driven ON bipolar cells of the white perch retina.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chloride Channels; Chlorides; Cycloleucine; Dendrites; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurotoxins; Patch-Clamp Techniques; Perches; Picrotoxin; Quinoxalines; Quisqualic Acid; Receptors, Metabotropic Glutamate; Retina; Retinal Cone Photoreceptor Cells; Strychnine | 1995 |
AMPA receptor activation regulates the glutamate metabotropic receptor stimulated phosphatidylinositol turnover in human cerebral cortex slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcimycin; Cerebral Cortex; Child; Cycloleucine; Dizocilpine Maleate; Female; Glutamic Acid; Humans; Male; Middle Aged; N-Methylaspartate; Phosphatidylinositols; Quisqualic Acid; Receptors, AMPA; Receptors, Metabotropic Glutamate; Signal Transduction; Tetrodotoxin | 1995 |
GFAP-positive hippocampal astrocytes in situ respond to glutamatergic neuroligands with increases in [Ca2+]i.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Rats | 1995 |
Modulation by ionotropic excitatory amino acids and potassium of (+/-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid-stimulated phosphoinositide hydrolysis in mouse cerebellar granule cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Survival; Cerebellum; Cycloleucine; Drug Synergism; Excitatory Amino Acids; Hydrolysis; Magnesium; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Phosphatidylinositols; Potassium; Receptors, Amino Acid; Receptors, Metabotropic Glutamate | 1995 |
Transient coupling of NMDA receptor with ip3 production in cultured cells of the avian retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Chick Embryo; Cycloleucine; Dizocilpine Maleate; gamma-Aminobutyric Acid; Inositol 1,4,5-Trisphosphate; Kainic Acid; N-Methylaspartate; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Retina; Time Factors | 1995 |
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.
Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line; Chelating Agents; Cycloleucine; Embryo, Mammalian; Fetus; Glioma; Glutamic Acid; Hippocampus; Humans; Indoles; Kidney; Kinetics; Maleimides; N-Methylaspartate; Neuroblastoma; Neurons; Neurotoxins; PC12 Cells; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Protein Kinase C; Protein Processing, Post-Translational; Pyrimidines; Quinacrine; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1995 |
Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cerebral Cortex; Cycloleucine; Glycine; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Phosphatidylinositols; Rats; Receptors, Glutamate; Spinal Cord; Thalamus | 1993 |
(R,S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors mediate a calcium-dependent inhibition of the metabotropic glutamate receptor-stimulated formation of inositol 1,4,5-trisphosphate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol 1,4,5-Trisphosphate; N-Methylaspartate; Protein Kinases; Rats; Receptors, AMPA; Receptors, Glutamate | 1993 |
Quisqualate resolves two distinct metabotropic [3H]glutamate binding sites.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Corpus Striatum; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid | 1993 |
Stimulation by glutamate receptors of arachidonic acid release depends on the Na+/Ca2+ exchanger in neuronal cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Calcium; Carrier Proteins; Cells, Cultured; Corpus Striatum; Cycloleucine; Electrophysiology; Ibotenic Acid; Mice; N-Methylaspartate; Neurons; Phospholipases A; Phospholipases A2; Protein Kinase C; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sodium; Sodium-Calcium Exchanger; Veratridine; Virulence Factors, Bordetella | 1993 |
Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzoates; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; Ibotenic Acid; Motor Neurons; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Neurotoxins; Rats; Spinal Cord; Stereoisomerism; Thalamus | 1993 |
Excitatory amino acid-induced slow biphasic responses of free intracellular calcium in human neuroblastoma cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcium; Cycloleucine; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Tumor Cells, Cultured | 1993 |
Acute mechanical hyperalgesia is produced by coactivation of AMPA and metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Hot Temperature; Ibotenic Acid; Male; N-Methylaspartate; Neurotoxins; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Quinoxalines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Spinal Cord | 1993 |
Toward an understanding of the role of glutamate in experimental parkinsonism: agonist-sensitive sites in the basal ganglia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Ganglia; Cycloleucine; Electromyography; Glutamates; Glutamic Acid; Kainic Acid; Male; Muscles; N-Methylaspartate; Parkinson Disease; Rats; Receptors, Glutamate | 1993 |
Metabotropic glutamate receptors negatively coupled to adenylate cyclase inhibit N-methyl-D-aspartate receptor activity and prevent neurotoxicity in mesencephalic neurons in vitro.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acids, Dicarboxylic; Animals; Cells, Cultured; Cyclic GMP; Cycloleucine; GTP-Binding Proteins; In Vitro Techniques; Mesencephalon; Mice; N-Methylaspartate; Neurons; Neurotoxins; Phosphatidylinositols; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems | 1995 |
Modulation of NMDA effects on agonist-stimulated phosphoinositide turnover by memantine in neonatal rat cerebral cortex.
Topics: Animals; Animals, Newborn; Carbachol; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Drug Interactions; Female; Inositol 1,4,5-Trisphosphate; Male; Memantine; N-Methylaspartate; Neurotoxins; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Polyphosphates; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1995 |
(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid attenuates N-methyl-D-aspartate-induced neuronal cell death in cortical cultures via a reduction in delayed Ca2+ accumulation.
Topics: Animals; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Cycloleucine; Fetus; Glutamates; Glutamic Acid; Kinetics; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neurotoxins; Pertussis Toxin; Phosphatidylinositols; Rats; Time Factors; Virulence Factors, Bordetella | 1993 |
An ibotenate-selective metabotropic glutamate receptor mediates protein phosphorylation in cultured hippocampal pyramidal neurons.
Topics: Animals; Calcium; Cycloleucine; Diglycerides; Embryo, Mammalian; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol; Inositol Phosphates; Kainic Acid; Myristic Acid; Myristic Acids; N-Methylaspartate; Nerve Tissue Proteins; Neurotoxins; Pertussis Toxin; Phosphatidylcholines; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Protein Kinase C; Pyramidal Cells; Quisqualic Acid; Rats; Receptors, Glutamate; Stearic Acids; Virulence Factors, Bordetella | 1994 |
Activation of glutamate receptors stimulates the formation of nitrite in synaptosomes from rat cerebellum.
Topics: Animals; Cerebellum; Cycloleucine; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Nitrites; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synaptosomes | 1994 |
Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S,3R-ACPD in neonatal rat cerebral cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Calcium; Cerebral Cortex; Cycloleucine; Dizocilpine Maleate; Female; Hydrolysis; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; N-Methylaspartate; Neurotoxins; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1994 |
Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Animals, Newborn; Cycloleucine; Excitatory Amino Acids; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Neurons, Afferent; Neurotoxins; Rats; Receptors, Metabotropic Glutamate; Spinal Cord; Synapses | 1994 |
L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a.
Topics: Alanine Transaminase; Animals; Asparagine; Aspartic Acid; Cell Line; Cell Membrane; Cricetinae; Cycloleucine; Cysteine; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Glutamate Decarboxylase; Glutamic Acid; Hydrolysis; Kidney; N-Methylaspartate; Phosphatidylinositols; Pyrrolidines; Receptors, Metabotropic Glutamate | 1994 |
Metabotropic glutamate receptors modulate N-methyl-D-aspartate receptor function in neostriatal neurons.
Topics: Action Potentials; Alanine; Animals; Cycloleucine; Iontophoresis; Male; Microelectrodes; N-Methylaspartate; Neostriatum; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses | 1994 |
Glutamate metabotropic receptor mediated depression of synaptic inputs to lamprey reticulospinal neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Axons; Cycloleucine; Electric Stimulation; Electrophysiology; Evoked Potentials; GTP-Binding Proteins; Ketamine; Lampreys; Microelectrodes; N-Methylaspartate; Neurons; Receptors, Glutamate; Reticular Formation; Rhombencephalon; Spinal Cord; Synapses | 1993 |
Pharmacological characterization of metabotropic glutamate receptors in cultured cerebellar granule cells.
Topics: Alanine; Amino Acids, Diamino; Animals; Cells, Cultured; Cerebellum; Cyanobacteria Toxins; Cycloleucine; Drug Interactions; Enzyme Activation; Glutamates; Glutamic Acid; Ibotenic Acid; Magnesium; N-Methylaspartate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Quisqualic Acid; Rats; Receptors, Glutamate | 1993 |
Excitatory amino acids (EAAs) stimulate phosphatidylinositol turnover in adult rat striatal slices: interaction between NMDA and EAA metabotropic receptors.
Topics: Amino Acids; Animals; Calcium; Corpus Striatum; Cycloleucine; Drug Interactions; Extracellular Space; In Vitro Techniques; Male; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Time Factors | 1994 |
Effects of t-ACPD on neural survival and second messengers in cultured cerebral cortical neurones.
Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Cycloleucine; Hydrolysis; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Neurons; Phosphatidylinositols; Receptors, Metabotropic Glutamate; Second Messenger Systems | 1993 |
Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine.
Topics: Animals; Animals, Newborn; Benzoates; Cerebral Cortex; Chromatography, High Pressure Liquid; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Phosphatidylinositols; Rats; Spinal Cord; Synapses; Thalamus | 1993 |
Coactivation of metabotropic and NMDA receptors is required for LTP induction.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alanine; Animals; Carbachol; Cyclic AMP; Cycloleucine; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Thionucleotides | 1993 |
Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in rat hippocampal slices.
Topics: Animals; Arachidonic Acid; Calcium; Cyclic AMP; Cycloleucine; Drug Synergism; Enzyme Activation; Female; Hippocampus; In Vitro Techniques; Magnesium; N-Methylaspartate; Neuronal Plasticity; Neurotoxins; Protein Kinase C; Rats; Receptors, Glutamate; Signal Transduction; Stereoisomerism; Tetrodotoxin | 1993 |
A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord.
Topics: Amino Acids; Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Cycloleucine; Cyclopropanes; Electric Stimulation; Electrophysiology; Glycine; In Vitro Techniques; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Reflex, Monosynaptic; Spinal Cord | 1993 |
In rats, the metabotropic glutamate receptor-triggered hippocampal neuronal damage is strain-dependent.
Topics: Animals; Behavior, Animal; Brain Diseases; Cycloleucine; Drug Synergism; Hippocampus; Male; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Inbred BN; Rats, Inbred F344; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptors, Glutamate | 1993 |
Co-activation of metabotropic glutamate and N-methyl-D-aspartate receptors is involved in mechanisms of long-term potentiation maintenance in rat hippocampal CA1 neurons.
Topics: Alanine; Animals; Cycloleucine; Electrophysiology; Hippocampus; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses | 1993 |
Characterization of the glutamate receptors mediating release of somatostatin from cultured hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Cycloleucine; Dizocilpine Maleate; Drug Synergism; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Somatostatin; Tetrodotoxin | 1996 |
Calcium ion impedes translation initiation at the synapse.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cerebral Cortex; Cycloleucine; Depression, Chemical; Gene Expression Regulation; Ionophores; Long-Term Potentiation; N-Methylaspartate; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Protein Biosynthesis; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Ribosomes; RNA, Messenger; Sulfonamides; Synapses | 1996 |
Pharmacology of metabotropic glutamate receptor-mediated enhancement of responses to excitatory and inhibitory amino acids on rat spinal neurones in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cycloleucine; Electrophoresis; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Spinal Cord | 1995 |
Metabotropic glutamate receptor subtypes differentially influence neuronal recovery from in vitro hypoxia/hypoglycemia in rat hippocampal slices.
Topics: Adenosine Triphosphate; Animals; Cycloleucine; Electrophysiology; Energy Metabolism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Phosphocreatine; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1995 |
Presynaptic actions of glutamate receptor agonists in the CA1 region of rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic | 1995 |
A comparison of the effects of selective metabotropic glutamate receptor agonists on synaptically evoked whole cell currents of rat spinal ventral horn neurones in vitro.
Topics: Aminobutyrates; Animals; Anterior Horn Cells; Cycloleucine; Depression, Chemical; Excitatory Amino Acid Agonists; N-Methylaspartate; Neurons; Neurotoxins; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1995 |
Metabotropic and ionotropic glutamate receptors mediate opposite effects on periaqueductal gray matter.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Blood Pressure; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Microinjections; N-Methylaspartate; Neurons; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate | 1995 |
Persistent increase in dopamine release following activation of metabotropic glutamate receptors in the rat nucleus accumbens.
Topics: Animals; Benzoates; Chromatography, High Pressure Liquid; Cycloleucine; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Male; Microdialysis; N-Methylaspartate; Neurotoxins; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1995 |
Calcium signalling in granule neurones studied in cerebellar slices.
Topics: Acetylcholine; Age Factors; Animals; Animals, Newborn; Caffeine; Calcium; Calcium Channel Agonists; Cerebellum; Cycloleucine; Electric Conductivity; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Homeostasis; Ion Channel Gating; Mice; Mice, Inbred CBA; N-Methylaspartate; Neurons; Neurotoxins; Organ Culture Techniques; Phosphodiesterase Inhibitors; Quisqualic Acid; Sensitivity and Specificity; Signal Transduction | 1996 |
Agonist-evoked Ca2+ mobilization from stores expressing inositol 1,4,5-trisphosphate receptors and ryanodine receptors in cerebellar granule neurones.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Calcium-Binding Proteins; Carbachol; Central Nervous System Stimulants; Cerebellum; Cycloleucine; Down-Regulation; Excitatory Amino Acid Agonists; Female; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Male; Muscle Proteins; N-Methylaspartate; Neurons; Neurotoxins; Nicotinic Agonists; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Ryanodine Receptor Calcium Release Channel; Signal Transduction | 1996 |
Opposing effects on blood pressure following the activation of metabotropic and ionotropic glutamate receptors in raphe obscurus in the anaesthetized rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Benzoates; Blood Pressure; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hypertension; Male; Microinjections; N-Methylaspartate; Neurotoxins; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Valine | 1996 |
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; Cerebral Cortex; Cricetinae; Cyclic AMP; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Kidney; Kinetics; Mice; N-Methylaspartate; Neuroglia; Neurons; Neurotoxins; Phosphatidylinositols; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 1996 |
L-Glutamate-induced responses in OFF-type bipolar cells of the cat retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Calcium; Cats; Chlorides; Cycloleucine; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; In Vitro Techniques; Ion Transport; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Potassium; Retina; Retinal Cone Photoreceptor Cells; Sodium | 1996 |
Time-dependent increase in release of arachidonic acid following passive avoidance training in the day-old chick.
Topics: Age Factors; Animals; Arachidonic Acid; Avoidance Learning; Carbon Radioisotopes; Chickens; Cycloleucine; Excitatory Amino Acid Agonists; Female; Male; N-Methylaspartate; Neurotoxins; Potassium Chloride; Receptors, Glutamate; Signal Transduction; Time Factors | 1996 |
Activation of multiple metabotropic glutamate receptor subtypes prevents NMDA-induced excitotoxicity in rat hippocampal slices.
Topics: Animals; Benzoates; Cycloleucine; Excitatory Amino Acid Antagonists; Female; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neuroprotective Agents; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1996 |
Developmental changes in glutamate receptor-activated translocation of protein kinase C in cerebellar granule neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Biological Transport; Carcinogens; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurotoxins; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Tritium | 1996 |
Pharmacological characterization of metabotropic glutamate receptors potentiating NMDA responses in mouse cortical wedge preparations.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Cycloleucine; Drug Synergism; Excitatory Amino Acid Agonists; In Vitro Techniques; Male; Mice; N-Methylaspartate; Neurotoxins; Receptors, Metabotropic Glutamate | 1996 |
Metabotropic glutamate receptor activation selectively limits excitotoxic damage in the intact neostriatum.
Topics: Analysis of Variance; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Kainic Acid; Male; Microinjections; N-Methylaspartate; Neostriatum; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1996 |
Metabotropic glutamate receptors potentiate responses to NMDA and AMPA from layer V cells in rat visual cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Drug Synergism; Excitatory Amino Acid Agonists; In Vitro Techniques; Iontophoresis; N-Methylaspartate; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Visual Cortex | 1996 |
Thyrotropin-releasing hormone (TRH) attenuates glutamate-stimulated increases in calcium in primary neuronal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Electrophysiology; Glutamic Acid; Intracellular Membranes; Ion Channel Gating; N-Methylaspartate; Neurons; Rats; Thyrotropin-Releasing Hormone | 1996 |
Tachycardia after glutamate injection in rat spinal cord is not blocked by kynurenate or mimicked by metabotropic agonists.
Topics: Aminobutyrates; Analysis of Variance; Animals; Blood Pressure; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Injections, Spinal; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred WKY; Receptors, Metabotropic Glutamate; Spinal Cord; Tachycardia | 1996 |
G-protein activation by metabotropic glutamate receptors reduces spike frequency adaptation in neocortical neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adult; Alanine; Amino Acids, Dicarboxylic; Animals; Benzoates; Cycloleucine; Enzyme Inhibitors; Frontal Lobe; Glycine; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Isoquinolines; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Protein Kinase Inhibitors; Protein Kinases; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction; Staurosporine; Sulfonamides; Thionucleotides | 1996 |
Potentiation of spontaneous acetylcholine release from motor nerve terminals by glutamate in Xenopus tadpoles.
Topics: Acetylcholine; Alanine; Animals; Calcium; Calcium Channel Blockers; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Larva; Motor Endplate; N-Methylaspartate; Neurotoxins; Quisqualic Acid; Second Messenger Systems; Verapamil; Xenopus laevis | 1996 |
Excitatory amino acid regulation of astrocyte proteoglycans.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; CD57 Antigens; Cell Membrane; Cells, Cultured; Chondroitin Sulfates; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Heparitin Sulfate; Hippocampus; Immunohistochemistry; Kainic Acid; N-Methylaspartate; Protein Kinase C; Rats; Receptors, Metabotropic Glutamate; Subcellular Fractions; Sulfates; Sulfur Radioisotopes | 1996 |
The influence of nitric oxide on perigeniculate GABAergic cell activity in the anaesthetized cat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Cycloleucine; Enzyme Inhibitors; gamma-Aminobutyric Acid; Geniculate Bodies; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Penicillamine; Photic Stimulation; Quisqualic Acid; S-Nitroso-N-Acetylpenicillamine | 1996 |
Activation of metabotropic glutamate receptors increases endogenous protein kinase C substrate phosphorylation in adult hippocampal slices.
Topics: Animals; Autoradiography; Biotransformation; Cycloleucine; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Isoenzymes; Male; N-Methylaspartate; Neuroprotective Agents; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Subcellular Fractions; Tetradecanoylphorbol Acetate | 1997 |
An electrophysiological study of neurons in the horizontal limb of the diagonal band of Broca.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Frontal Lobe; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetrodotoxin | 1997 |
Characterization of metabotropic glutamate receptor-mediated nitric oxide production in vivo.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Biomarkers; Calcium Channels; Citrulline; Cycloleucine; Dantrolene; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Male; Microdialysis; Muscle Proteins; N-Methylaspartate; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Ryanodine Receptor Calcium Release Channel; Tetrodotoxin | 1997 |
Effects of glutamate receptor agonists and antagonists on Ca2+ uptake in rat hippocampal slices lesioned by glucose deprivation or by kainate.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glucose; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Organ Culture Techniques; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Synaptic Transmission | 1997 |
Activation of hamster suprachiasmatic neurons in vitro via metabotropic glutamate receptors.
Topics: Animals; Cricetinae; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Extracellular Space; In Vitro Techniques; Male; Mesocricetus; N-Methylaspartate; Neurons; Receptors, Metabotropic Glutamate; Suprachiasmatic Nucleus | 1996 |
Pressor and sympathetic responses to excitatory amino acids are not augmented in the ventrolateral medulla of Dahl salt-sensitive rats.
Topics: Analysis of Variance; Animals; Blood Pressure; Body Weight; Cycloleucine; Diet, Sodium-Restricted; Excitatory Amino Acid Agonists; Glutamic Acid; Heart Rate; Male; Medulla Oblongata; Microinjections; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Inbred Strains; Sodium, Dietary; Splanchnic Circulation; Sympathetic Nervous System | 1997 |
Differential regulation of neuronal proteoglycans by activation of excitatory amino acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Chondroitin Sulfate Proteoglycans; Cycloleucine; DNA Primers; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Glycosylphosphatidylinositols; Glypicans; Heparan Sulfate Proteoglycans; Hippocampus; Lectins, C-Type; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurocan; Neurons; Neuroprotective Agents; Polymerase Chain Reaction; Proteoglycans; Rats; Receptors, Glutamate; RNA, Messenger; Transcription, Genetic | 1997 |
1S, 3R-ACPD induces a region of negative slope conductance in the steady-state current-voltage relationship of hippocampal pyramidal cells.
Topics: Animals; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Kinetics; Membrane Potentials; N-Methylaspartate; Neural Conduction; Patch-Clamp Techniques; Potassium Channels; Pyramidal Cells; Rats; Receptors, Metabotropic Glutamate | 1997 |
Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Animals, Newborn; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamates; Glycine; N-Methylaspartate; Rats; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Spinal Cord | 1996 |
Enhancement of NMDA responses by group I metabotropic glutamate receptor activation in striatal neurones.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agents; Glycine; Male; N-Methylaspartate; Neostriatum; Neurons; Patch-Clamp Techniques; Protein Kinase C; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols | 1997 |
Regulation of cerebral microvessels by glutamatergic mechanisms.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Cerebrovascular Circulation; Cycloleucine; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Microcirculation; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synapses; Vasoconstriction; Vasodilation | 1997 |
Neuroprotective sigma ligands attenuate NMDA and trans-ACPD-induced calcium signaling in rat primary neurons.
Topics: Animals; Calcium; Cells, Cultured; Cycloleucine; Ligands; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, sigma; Signal Transduction | 1997 |
N-methyl-D-aspartic acid-induced penile erection and yawning: role of hypothalamic paraventricular nitric oxide.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hemoglobins; Male; Methylene Blue; Microdialysis; N-Methylaspartate; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxytocin; Paraventricular Hypothalamic Nucleus; Penile Erection; Rats; Rats, Sprague-Dawley; Yawning | 1997 |
Two pathways of nitric oxide production through glutamate receptors in the rat cerebellum in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine; Calcium; Cerebellum; Cycloleucine; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Male; N-Methylaspartate; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Rats, Wistar; Receptors, Glutamate | 1997 |
Glutamate-dependent activation of NF-kappaB during mouse cerebellum development.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; Animals; Antibody Specificity; Cell Nucleus; Cerebellum; Cycloleucine; Cytoplasm; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Developmental; Glutamic Acid; Injections, Intraperitoneal; Mice; Mice, Transgenic; N-Methylaspartate; Neuroprotective Agents; Neurotransmitter Agents; NF-kappa B; Transgenes | 1997 |
Changes in extracellular nitrite and nitrate levels after inhibition of glial metabolism with fluorocitrate.
Topics: Aconitate Hydratase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Benzoates; Cerebellum; Citrates; Citric Acid Cycle; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glycine; Male; N-Methylaspartate; Neuroglia; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Nitroarginine; Quinoxalines; Rats; Rats, Wistar; Substrate Specificity | 1997 |
Influences of excitatory amino acid receptor agonists on nucleus of the solitary tract neurons receiving aortic depressor nerve inputs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aorta; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Nervous System Physiological Phenomena; Neurons; Rats; Rats, Sprague-Dawley; Solitary Nucleus | 1997 |
Potentiation of NMDA and AMPA responses by group I mGluR in spinal cord motoneurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Drug Synergism; Excitatory Amino Acid Agonists; Glycine; In Vitro Techniques; Male; Membrane Potentials; Motor Neurons; N-Methylaspartate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord | 1997 |
Impairment of brain kynurenic acid production by glutamate metabotropic receptor agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Cycloleucine; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Sodium | 1997 |
Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzoates; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Kinetics; Motor Neurons; N-Methylaspartate; Neuroprotective Agents; Rats; Spinal Cord | 1997 |
The involvement of metabotropic glutamate receptors in sensory transmission in dorsal horn of the rat spinal cord.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agonists; Extracellular Space; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord; Synaptic Transmission | 1998 |
Modulation of GAP-43 mRNA by GABA and glutamate in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Blotting, Northern; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; gamma-Aminobutyric Acid; GAP-43 Protein; Gene Expression Regulation, Developmental; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunohistochemistry; In Situ Hybridization; Microtubule-Associated Proteins; Muscimol; N-Methylaspartate; Neurons; Neuroprotective Agents; Piperazines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1998 |
Opposing regulation of tau protein levels by ionotropic and metabotropic glutamate receptors in human NT2 neurons.
Topics: Cell Death; Cell Line; Cycloleucine; Excitatory Amino Acid Agonists; Gene Expression; Humans; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; tau Proteins | 1998 |
Evidence that functional glutamate receptors are not expressed on rat or human cerebromicrovascular endothelial cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Calcium; Capillaries; Cattle; Cells, Cultured; Cerebrovascular Circulation; Colforsin; Cyclic AMP; Cycloleucine; Endothelin-1; Endothelium, Vascular; Gene Expression; Humans; Inositol 1,4,5-Trisphosphate; Kainic Acid; Mice; N-Methylaspartate; Neurons; Polymerase Chain Reaction; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Second Messenger Systems | 1998 |
Enhanced visual responses in cat dLGN--potentiation by priming with excitatory amino acids.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Cycloleucine; Drug Synergism; Excitatory Amino Acids; Geniculate Bodies; Iontophoresis; N-Methylaspartate; Neurons; Neuroprotective Agents; Photic Stimulation; Visual Perception | 1998 |
Prenatal ethanol exposure enhances glutamate release stimulated by quisqualate in rat cerebellar granule cell cultures.
Topics: Alcoholism; Amino Acids; Animals; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Ethanol; Female; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Potassium Chloride; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1998 |
Effect of glutamate receptor agonists on catecholamine secretion in bovine chromaffin cells.
Topics: Adrenal Medulla; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nicotine; Receptors, Glutamate | 1998 |
Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonist S-2-methyl-4-carboxy-phenylglycine.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Male; N-Methylaspartate; Naphthols; Neurons, Afferent; Neuroprotective Agents; Propylene Glycols; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Thalamus | 1998 |
Metabotropic glutamate receptor activation modulates sound level processing in the cochlear nucleus.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Auditory Pathways; Auditory Perception; Benzoates; Cats; Cochlear Nucleus; Cycloleucine; Evoked Potentials; Excitatory Amino Acid Antagonists; Gerbillinae; Glycine; N-Methylaspartate; Neurons; Neuroprotective Agents; Receptors, Metabotropic Glutamate; Time Factors | 1998 |
Glutamate-stimulated neuropeptide Y mRNA expression in the rat dentate gyrus: a prominent role of metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Injections; Injections, Intraperitoneal; Male; N-Methylaspartate; Neuropeptide Y; Neuropeptides; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; RNA, Messenger | 1998 |
The group III metabotropic glutamate receptor agonist, l-AP4, reduces EPSPs in some layers of rat visual cortex.
Topics: Alanine; Aminobutyrates; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; N-Methylaspartate; Neuroprotective Agents; Presynaptic Terminals; Rats; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Visual Cortex | 1998 |
Changes in GluR4 expression induced by metabotropic receptor activation in radial glia cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Chick Embryo; Cycloleucine; Glutamic Acid; Kainic Acid; Kinetics; N-Methylaspartate; Neuroglia; Polymerase Chain Reaction; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Metabotropic Glutamate; Retina; RNA, Messenger; Transcription, Genetic; Up-Regulation | 1998 |
Characterization of neuroprotection from excitotoxicity by moderate and profound hypothermia in cultured cortical neurons unmasks a temperature-insensitive component of glutamate neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Cold Temperature; Cycloleucine; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Fluorescent Dyes; Glutamic Acid; Humans; Hypothermia, Induced; Kainic Acid; Mice; N-Methylaspartate; Neuroglia; Neurons; Neurotoxins; Synapses | 1998 |
Low-affinity kainate receptors and long-lasting depression of NMDA-receptor-mediated currents in rat superficial dorsal horn.
Topics: Action Potentials; Animals; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Glutamic Acid; Indoles; Ion Channel Gating; Kainic Acid; Male; N-Methylaspartate; Neurons, Afferent; Neuroprotective Agents; Oximes; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission | 1998 |
Stimulation of Na+-K+-2Cl- cotransporter in neuronal cells by excitatory neurotransmitter glutamate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Bumetanide; Carrier Proteins; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agents; Gene Expression Regulation; Glutamic Acid; Humans; Kinetics; N-Methylaspartate; Neuroblastoma; Neurons; Potassium; Receptors, Glutamate; Sodium-Potassium-Chloride Symporters; Tumor Cells, Cultured | 1998 |
Regulation of intrinsic and synaptic properties of neonatal rat trigeminal motoneurons by metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzoates; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neuroprotective Agents; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrodotoxin; Trigeminal Nuclei | 1998 |
The effect of ACPD on the responses to NMDA and AMPA varies with layer in slices of rat visual cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Drug Synergism; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Visual Cortex | 1998 |
Endogenous activation of metabotropic glutamate receptors contributes to burst frequency regulation in the lamprey locomotor network.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Lampreys; Locomotion; Membrane Potentials; N-Methylaspartate; Nerve Net; Periodicity; Propionates; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord; Synaptic Transmission | 1998 |
Conformational changes of the smooth endoplasmic reticulum are facilitated by L-glutamate and its receptors in rat Purkinje cells.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apnea; Bradycardia; Calcium Signaling; Cycloleucine; Dendrites; Endoplasmic Reticulum, Smooth; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia, Brain; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Neuroprotective Agents; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Respiration | 1998 |
Mechanisms involved in the metabotropic glutamate receptor-enhancement of NMDA-mediated motoneurone responses in frog spinal cord.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Benzoates; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Chlorpromazine; Cycloleucine; Dose-Response Relationship, Drug; Drug Synergism; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; GTP-Binding Proteins; In Vitro Techniques; Kynurenic Acid; Magnesium; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neuroprotective Agents; Pertussis Toxin; Rana pipiens; Receptors, Metabotropic Glutamate; Reflex; Resorcinols; Second Messenger Systems; Spinal Cord; Sulfonamides; Tetrodotoxin; Thapsigargin; Virulence Factors, Bordetella | 1999 |
mGluR7-like metabotropic glutamate receptors inhibit NMDA-mediated excitotoxicity in cultured mouse cerebellar granule neurons.
Topics: Animals; Calcium Channels; Cell Death; Cells, Cultured; Cerebellum; Cyclic GMP; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Mice; Microtubule-Associated Proteins; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Patch-Clamp Techniques; Phosphoserine; Propionates; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
The effects of excitatory amino acids on isolated gut segments of the rat.
Topics: Animals; Aspartic Acid; Cycloleucine; Digestive System; Digestive System Physiological Phenomena; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Female; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; N-Methylaspartate; Neuroprotective Agents; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Cardiovascular responses to microinjections of excitatory amino acids into the area postrema of the rat.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Intravenous; Animals; Blood Pressure; Bradycardia; Cerebral Ventricles; Cycloleucine; Decerebrate State; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Male; Microinjections; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Wistar; Tachycardia; Urethane | 1999 |
Cardiovascular response to group I metabotropic glutamate receptor activation in NTS.
Topics: Animals; Baroreflex; Benzoates; Blood Pressure; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Kynurenic Acid; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sympathetic Nervous System | 1999 |
Activation of NMDA receptors protects against glutamate neurotoxicity in the retina: evidence for the involvement of neurotrophins.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Growth Factors; Neuroprotective Agents; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptors, N-Methyl-D-Aspartate; Receptors, Nerve Growth Factor; Retina | 1999 |
Metabotropic glutamate receptor modulation of excitotoxicity in the neostriatum: role of calcium channels.
Topics: Animals; Barium; Brain Edema; Cadmium; Calcium Channel Blockers; Calcium Channels; Cycloleucine; Excitatory Amino Acid Agonists; Glycine; Membrane Potentials; Methoxyhydroxyphenylglycol; Microscopy, Video; N-Methylaspartate; Neostriatum; Neuroprotective Agents; Neurotoxins; omega-Conotoxin GVIA; Organ Culture Techniques; Patch-Clamp Techniques; Peptides; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1999 |
Activation of N-methyl-D-aspartate receptors reverses desensitization of metabotropic glutamate receptor, mGluR5, in native and recombinant systems.
Topics: Animals; Brain; Cycloleucine; Electrophysiology; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neuroprotective Agents; Oocytes; Phosphoprotein Phosphatases; Phosphorylation; Rats; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Xenopus | 1999 |
Functional activation of punch-cultured magnocellular neuroendocrine cells by glutamate receptor subtypes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine Vasopressin; Calcium; Cell Culture Techniques; Cells, Cultured; Cycloleucine; Excitatory Amino Acid Agonists; Fetus; Kainic Acid; N-Methylaspartate; Neurons; Neurophysins; Neurosecretory Systems; Patch-Clamp Techniques; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Supraoptic Nucleus | 1999 |
NMDA and non-NMDA receptor-mediated excitotoxicity are potentiated in cultured striatal neurons by prior chronic depolarization.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Corpus Striatum; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Fetus; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Potassium Chloride; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Endogenous activation of metabotropic glutamate receptors in neocortical development causes neuronal calcium oscillations.
Topics: Animals; Calcium; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Lysine; Mice; Microscopy, Fluorescence; N-Methylaspartate; Neocortex; Neuroglia; Neurons; Neuroprotective Agents; Protein Isoforms; Receptors, Metabotropic Glutamate; Time Factors | 1999 |
Evaluation of agonists and antagonists acting at Group I metabotropic glutamate receptors in the thalamus in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Phospholipid Ethers; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Thalamus | 1999 |
Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzophenanthridines; Calcium; Cycloleucine; Drug Synergism; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Membrane Potentials; Motor Neurons; N-Methylaspartate; Phenanthridines; Phenylacetates; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Spinal Cord | 1999 |
Regulation of NMDA-stimulated [14C]GABA and [3H]acetylcholine release by striatal glutamate and dopamine receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Carbon Radioisotopes; Corpus Striatum; Cycloleucine; Dopamine Agonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; N-Methylaspartate; Proline; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
Regulation of substantia nigra pars reticulata neuronal activity by excitatory amino acids.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Substantia Nigra | 1999 |
Locomotor activity and accumbens Fos expression driven by ventral hippocampal stimulation require D1 and D2 receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Benzazepines; Brain Chemistry; Cycloleucine; Dextroamphetamine; Dopamine Agents; Dopamine Antagonists; Excitatory Amino Acid Agonists; Genes, Immediate-Early; Glutamic Acid; Haloperidol; Hippocampus; Kainic Acid; Lidocaine; Locomotion; Male; N-Methylaspartate; Neural Pathways; Neuroprotective Agents; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1999 |
Alterations in calcium-mediated signal transduction after traumatic injury of cortical neurons.
Topics: Animals; Brain Injuries; Calcium; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Neuroglia; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Thapsigargin | 1999 |
Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Cell Survival; Choline O-Acetyltransferase; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Situ Nick-End Labeling; In Vitro Techniques; Kainic Acid; Male; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord | 2000 |
Physiological activation of presynaptic metabotropic glutamate receptors increases intracellular calcium and glutamate release.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Brain Stem; Calcium; Chromones; Cycloleucine; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorometry; Glutamic Acid; Glycine Agents; GTP-Binding Proteins; In Vitro Techniques; Lampreys; Larva; Membrane Potentials; N-Methylaspartate; Neuronal Plasticity; Neuroprotective Agents; Patch-Clamp Techniques; Presynaptic Terminals; Quisqualic Acid; Receptors, Metabotropic Glutamate; Strychnine; Tetrodotoxin | 2000 |
Glutamate-mediated neuroprotection against N-methyl-D-aspartate toxicity: a role for metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cell Death; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Neuroprotective Agents; Oligodeoxyribonucleotides, Antisense; Organ Culture Techniques; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Tetrodotoxin | 2000 |
Expression and regulation of Na pump isoforms in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Cerebellum; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Isoenzymes; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Potassium Radioisotopes; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 2001 |
The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures.
Topics: Animals; Coloring Agents; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Immunohistochemistry; In Vitro Techniques; Microtubule-Associated Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurotoxins; Propidium; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Staining and Labeling | 2001 |
Potentiation of a metabotropic glutamatergic response following NMDA receptor activation in rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cycloleucine; Excitatory Amino Acid Agonists; Hippocampus; N-Methylaspartate; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1994 |
Activation of metabotropic glutamate receptor 1 accelerates NMDA receptor trafficking.
Topics: Animals; Blotting, Western; Botulinum Toxins, Type A; Cell Membrane; Cells, Cultured; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exocytosis; Fluorescent Antibody Technique; Ion Channel Gating; Membrane Potentials; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Oocytes; Patch-Clamp Techniques; Protein Transport; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptosomal-Associated Protein 25; Transfection; Xenopus | 2001 |
Magnesium decreases arterial pressure and inhibits cardiovascular responses induced by N-methyl-D-aspartate and metabotropic glutamate receptors stimulation in rostral ventrolateral medulla.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Heart Rate; Magnesium; Magnesium Chloride; Magnesium Sulfate; Male; Medulla Oblongata; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2001 |
Modulation of dendritic release of dopamine by metabotropic glutamate receptors in rat substantia nigra.
Topics: Animals; Cycloleucine; Dendritic Cells; Dopamine; Excitatory Amino Acid Agonists; In Vitro Techniques; Male; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Tritium | 2002 |
Metabotropic and NMDA glutamate receptor interactions with osmotic stimuli in supraoptic neurons.
Topics: Animals; Calcium Signaling; Cells, Cultured; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Agonists; Female; Glycine; Image Processing, Computer-Assisted; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Neurosecretory Systems; Osmolar Concentration; Pregnancy; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Supraoptic Nucleus | 2002 |
Group I metabotropic glutamate receptor-mediated enhancement of dopamine cell burst firing in rat ventral tegmental area in vitro.
Topics: Action Potentials; Animals; Apamin; Benzoates; Biological Clocks; Cycloleucine; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Resorcinols; Ventral Tegmental Area | 2002 |
Activation of glutamate receptors inhibits Na/K-ATPase of cerebellum granule cells.
Topics: Alkaloids; Animals; Benzoates; Benzophenanthridines; Cerebellum; Cycloleucine; Cysteine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Glutamates; Glycine; Male; Mice; Mice, Inbred AKR; N-Methylaspartate; Neurons; Phenanthridines; Receptors, Glutamate; Sodium-Potassium-Exchanging ATPase | 2002 |
Carbon monoxide and metabotropic glutamate receptors in rat nucleus tractus solitarii: participation in cardiovascular effect.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Carbon Monoxide; Cardiovascular System; Cycloleucine; Deuteroporphyrins; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Heme Oxygenase (Decyclizing); Hemin; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Solitary Nucleus | 2002 |
Effects of calcium and glutamate receptor agonists on leaf consumption by lepidopteran neonates.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Feeding Behavior; Kainic Acid; Lepidoptera; N-Methylaspartate; Plant Leaves | 2003 |
Glutamate receptors regulate Na/K-ATPase in cerebellum neurons.
Topics: Animals; Cells, Cultured; Cerebellum; Cycloleucine; Glutamic Acid; Homeostasis; N-Methylaspartate; Neurons; Neurotoxins; Reactive Oxygen Species; Receptors, Glutamate; Sodium-Potassium-Exchanging ATPase | 2003 |
The role of ionotropic receptors of glutaminic acid in cardiovascular system. A. The influence of ionotropic receptor NMDA agonist - 1R,3R-ACPD and antagonist - DL-AP7 on the systemic pressure in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Chlorisondamine; Cycloleucine; Dose-Response Relationship, Drug; Heart Rate; Injections, Intravenous; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2003 |
Expression of group I metabotropic glutamate receptors in rat hippocampal cells in culture and their characterization by intracellular calcium ion dynamics.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Cycloleucine; Hippocampus; Intracellular Fluid; N-Methylaspartate; Rats; Rats, Wistar; Receptors, AMPA | 2003 |
NMDA receptors in nucleus tractus solitarii are linked to soluble guanylate cyclase.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminoquinolines; Animals; Baroreflex; Biotransformation; Blood Pressure; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Guanylate Cyclase; In Vitro Techniques; Male; Microinjections; N-Methylaspartate; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Stereotaxic Techniques | 2004 |
Effects of glutamate transporter and receptor ligands on neuronal glutamate uptake.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ligands; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Oxepins; Rats; Rats, Wistar; Receptors, Glutamate; Tritium; Valine | 2005 |
Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in mice.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Nociceptors; Pain; Receptors, Glutamate; Spinal Cord | 2006 |
The role of defensins in the excitability of the peripheral vestibular system in the frog: evidence for the presence of communication between the immune and nervous systems.
Topics: Acetylcholine; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha-Defensins; Animals; Atropine; Cholinergic Antagonists; Cycloleucine; Defensins; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Immune System; In Vitro Techniques; Inflammation; Kainic Acid; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neuroimmunomodulation; Neurons, Afferent; Rabbits; Rana temporaria; Receptors, Cholinergic; Receptors, Glutamate; Receptors, Opioid; Semicircular Canals; Synaptic Transmission; Vestibule, Labyrinth | 2007 |
Effect of exogenous glutamate and N-Methyl-D-aspartic acid on spontaneous activity of isolated human ureter.
Topics: Adult; Aged; Cycloleucine; Female; Glutamic Acid; Humans; In Vitro Techniques; Kainic Acid; Male; Middle Aged; Muscle, Smooth; N-Methylaspartate; Ureter | 2007 |
A peripheral neuroimmune link: glutamate agonists upregulate NMDA NR1 receptor mRNA and protein, vimentin, TNF-alpha, and RANTES in cultured human synoviocytes.
Topics: Animals; Arthritis; CD11b Antigen; Cell Line, Tumor; Chemokine CCL5; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; N-Methylaspartate; Neurogenic Inflammation; Neuroimmunomodulation; Protein Kinase C; Rats; Receptors, Complement 3d; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sarcoma, Synovial; Synovial Membrane; Synovitis; Tumor Necrosis Factor-alpha; Up-Regulation; Vimentin | 2010 |
The Effect of Glutamate Receptor Agonists on Mouse Retinal Astrocyte [Ca(2+)]i.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Calcium; Cycloleucine; Excitatory Amino Acid Agonists; Fura-2; Methoxyhydroxyphenylglycol; Mice, Inbred C57BL; N-Methylaspartate; Receptors, Glutamate; Retina | 2016 |