1-amino-1,3-dicarboxycyclopentane has been researched along with cycloleucine in 837 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (0.84) | 18.7374 |
| 1990's | 681 (81.36) | 18.2507 |
| 2000's | 140 (16.73) | 29.6817 |
| 2010's | 9 (1.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cerne, R; Randic, M | 1 |
| Hong, JS; McMillian, M; Pennypacker, KR | 1 |
| Alexander, SP; Curtis, AR; Hill, SJ; Kendall, DA | 1 |
| Haley, JE; Kitto, KF; Wilcox, GL | 1 |
| Johnson, BG; Monn, JA; Schoepp, DD | 2 |
| Alexander, SP; Cartmell, J; Hill, SJ; Kemp, JA; Kendall, DA | 1 |
| Garaschuk, OV; Kovalchuk, YN; Krishtal, OA | 1 |
| Akiyama, K; Daigen, A; Itoh, T; Kohira, I; Otsuki, S; Ujike, H; Yamada, N | 1 |
| Gallagher, JP; Zheng, F | 6 |
| Bymaster, FP; Sacaan, AI; Schoepp, DD | 1 |
| Li, PP; Vecil, GG; Warsh, JJ | 1 |
| Collingridge, GL; Irving, AJ; Schofield, JG | 1 |
| Alagarsamy, S; Johnson, KM; Lonart, G; Ravula, R; Wang, J | 1 |
| Hu, GY; Storm, JF | 1 |
| Aleppo, G; Aronica, E; Bruno, V; Canonico, PL; Copani, A; D'Agata, V; Nicoletti, F; Pisani, A | 1 |
| Casabona, G; Di Stefano, M; Genazzani, AA; Nicoletti, F; Sortino, MA | 1 |
| Bockaert, J; Manzoni, O; Prezeau, L; Sladeczek, F | 1 |
| Bortolotto, ZA; Collingridge, GL | 4 |
| Crepel, F; Daniel, H; Hemart, N; Jaillard, D | 2 |
| Radpour, S; Thomson, AM | 1 |
| Sheardown, MJ | 1 |
| Conn, PJ; Desai, MA; Smith, TS | 1 |
| Bridges, RJ; Cotman, CW; Miller, S | 2 |
| Kinney, GA; Slater, NT | 2 |
| Garashchuk, OV; Koval'chuk, IuN; Kryshtal', OA | 1 |
| Conn, PJ; Winder, DG | 3 |
| Alexander, SP; Hill, SJ; Kendall, DA | 1 |
| Bockaert, J; Curry, K; Homburger, V; Manzoni, O; Prezeau, L; Sladeczek, F | 1 |
| Bernardi, G; Calabresi, P; Mercuri, NB | 1 |
| Rainnie, DG; Shinnick-Gallagher, P | 1 |
| Crill, W; Greene, C; Schwindt, P | 1 |
| Herrero, I; Miras-Portugal, MT; Sánchez-Prieto, J | 1 |
| Boss, V; Conn, PJ; Desai, MA; Smith, TS | 1 |
| Ishida, M; Shinozaki, H | 1 |
| Clifford, DB; Izumi, Y; Zorumski, CF | 1 |
| de Barry, J; Kudo, Y; Takagi, H; Takimizu, H; Yoshioka, T | 1 |
| Hayashi, M; Hirose, E; Ito, I; Kohda, A; Mitsunaga, S; Sugiyama, H; Tanabe, S | 1 |
| Bleakman, D; Chard, PS; Glaum, SR; Miller, RJ; Rusin, KI | 1 |
| Bockaert, J; Curry, K; Manzoni, O; Prezeau, L; Rassendren, FA; Sladeczek, F | 1 |
| McDonald, JW; Schoepp, DD | 1 |
| Okada, D | 2 |
| East, SJ; Garthwaite, J | 1 |
| Gähwiler, BH; Gerber, U | 1 |
| Albertini, P; Chiamulera, C; Reggiani, A; Valerio, E | 1 |
| Fadda, E; Lipartiti, M; Manev, H; Sautter, J; Siliprandi, R | 1 |
| Sacaan, AI; Schoepp, DD | 1 |
| de Barry, J; Gombos, G; Levy, O | 1 |
| Lowe, DA; Roy, BL; Taschenberger, H | 1 |
| Constanti, A; Libri, V | 1 |
| Boss, V; Conn, PJ | 1 |
| Glaum, SR; Miller, RJ; Rossi, DJ; Slater, NT | 1 |
| Bockaert, J; Heinemann, SF; Pin, JP; Prezeau, L; Waeber, C | 1 |
| Schoepp, DD; True, RA | 1 |
| Pook, PC; Sunter, DC; Udvarhelyi, PM; Watkins, JC | 1 |
| Baskys, A; Malenka, RC | 2 |
| Baird, JG; Challiss, RA; Nahorski, SR | 1 |
| Courtney, MJ; Nicholls, DG | 1 |
| Anwyl, R; McGuinness, N; Rowan, M | 2 |
| Lovinger, DM | 1 |
| Cotman, CW; Koh, JY; Palmer, E | 1 |
| Monn, JA; Sacaan, AI; Schoepp, DD | 1 |
| Johnson, BG; Monn, JA; Schoepp, DD; True, RA | 1 |
| Cotman, CW; Koh, JY; Lin, A; Palmer, E | 1 |
| Ben-Ari, Y; Otani, S | 1 |
| Charpak, S; Gähwiler, BH | 1 |
| Cotman, CW; Whittemore, ER | 1 |
| Jacques-Berg, W; Patel, AJ; Rodriguez, J | 1 |
| Bockaert, J; Manzoni, OJ; Prezeau, L | 1 |
| Kelso, SR; Pacelli, GJ | 1 |
| Lanthorn, TH; Monaghan, DT; Watson, GB | 1 |
| Curry, K; McLarnon, JG | 1 |
| Aniksztejn, L; Ben-Ari, Y; Bregestovski, P | 1 |
| Corden, M; Curry, K; McLennan, H | 1 |
| Batchelor, A; Gähwiler, BH; Garthwaite, J; Knöpfel, T; Staub, C; Vranesic, I | 1 |
| Johnson, BG; Johnston, MV; McDonald, JW; Salhoff, CR; Schoepp, DD | 1 |
| Ito, I; Sugiyama, H; Tanabe, S | 1 |
| Baraban, JM; Stratton, KR; Worley, PF | 2 |
| Akagi, H; Ishida, M; Ohfune, Y; Shimamoto, K; Shinozaki, H | 1 |
| Bredt, DS; Hwang, PM; Snyder, SH | 1 |
| Bockaert, J; Dumuis, A; Oomagari, K; Pin, JP; Sebben, M | 1 |
| Courtney, MJ; Lambert, JJ; Nicholls, DG | 1 |
| Bockaert, J; Fagni, L; Manzoni, O; Pin, JP; Poulat, F; Rassendren, F; Sladeczek, F | 1 |
| Charpak, S; Do, KQ; Gähwiler, BH; Knöpfel, T | 1 |
| Collingridge, GL; Irving, AJ; Schofield, JG; Sunter, DC; Watkins, JC | 1 |
| Cotman, CW; Monaghan, DT; Palmer, E | 1 |
| Cotman, C; Monaghan, D | 1 |
| Miller, RF; Slaughter, MM | 1 |
| Curry, K; Magnuson, DS; McLennan, H; Peet, MJ | 1 |
| Kasafírek, E; Kosar, K; Vanzura, J | 1 |
| Lancaster, B; Wheal, HV | 1 |
| Baker, SR; Goldsworthy, JS; Johnson, BG; Salhoff, CR; Schoepp, DD; Wright, RA | 1 |
| Herrero, I; Miras-Portugal, MT; Sánchez-Prieto, J; Vázquez, E | 3 |
| Griffey, KI; Schoepp, DD; Tizzano, JP | 1 |
| Cherubini, E; Fisher, ND; Sciancalepore, M; Stratta, F | 1 |
| Brown, RE; Reymann, KG | 1 |
| Bernardi, G; Bonci, A; Calabresi, P; Mercuri, NB; Stratta, F | 1 |
| MacDermott, AB; Reichling, DB | 1 |
| Connor, JA; Linden, DJ; Smeyne, M | 2 |
| Miller, RF; Thoreson, WB | 2 |
| Fox, EA; Gruol, DL | 1 |
| Glowinski, J; Prémont, J; Stella, N; Tencé, M | 1 |
| Klitgaard, H; Laudrup, P | 2 |
| Johnson, BG; Schoepp, DD | 2 |
| Glaum, SR; Miller, RJ; Sunter, DC; Udvarhelyi, PM; Watkins, JC | 1 |
| Glaum, SR; Miller, RJ | 3 |
| Battaglia, G; Bruno, V; Copani, A; Nicoletti, F; Raffaele, R; Shinozaki, H | 1 |
| DiChiara, TJ; Kauer, JA; McBain, CJ | 1 |
| Argiolas, A; Melis, MR; Stancampiano, R | 1 |
| Herrera, AJ; Osborne, NN | 1 |
| Amico, C; Condorelli, DF; Dell'Albani, P; Giuffrida-Stella, AM; Kaczmarek, L; Lukasiuk, K | 1 |
| Cavanni, P; Eistetter, H; Ferraguti, F; Ratti, E; Salvagno, C; Trist, DG | 1 |
| Mikuni, M; Saitoh, K; Shinno, H; Takahashi, K; Tomita, U; Yamawaki, S | 1 |
| Lücke, T; Neugebauer, V; Schaible, HG | 1 |
| Boatright, JH; Gordon, JR; Iuvone, PM | 1 |
| Gebhart, GF; Meller, ST | 1 |
| Abe, I; Fujishima, M; Tsuchihashi, T | 1 |
| Alagarsamy, S; Johnson, KM; Lonart, G | 2 |
| Collins, DR; Davies, SN | 2 |
| Carlà, V; Cherici, G; Leonardi, P; Lombardi, G; Mannaioni, G; Moroni, F | 1 |
| Devillers, JP; Simonnet, G | 1 |
| Hansson, E; Johansson, BB; Rönnbäck, L; Westergren, I | 1 |
| Dowling, JE; Grant, GB | 1 |
| Acciarri, N; Beani, L; Bianchi, C; Calo, G; Fabrizi, A; Ferraro, L; Morari, M; Piazza, G | 1 |
| McCarthy, KD; Porter, JT | 1 |
| Brune, T; Deitmer, JW | 1 |
| Chad, JE; Jane, SD; Phenna, S | 1 |
| Llano, I; Marty, A | 1 |
| Beaver, KM; Hawkins, LM; Jane, DE; Roberts, PJ; Sunter, DC; Taylor, PM | 1 |
| Gotani, H; Kuno, M; Matsuura, S; Nakamura, F | 1 |
| Billard, JM; Dutar, P; Jouvenceau, A | 2 |
| Gorman, AM; Grieve, A; Griffiths, R | 1 |
| Fix, AS; Schoepp, DD; Tizzano, JP; Wright, RA | 1 |
| Chung, SH; Premkumar, L | 1 |
| Cotman, CW; Kesslak, JP; Miller, S; Romano, C | 1 |
| Mortensen, M; Suzdak, PD; Thomsen, C | 1 |
| de Mello, FG; de Mello, MC; Kubrusly, RC; Reis, RA | 1 |
| Brotchie, JM; East, SJ; Hill, MP | 1 |
| Albin, RL; Kaatz, KW | 2 |
| Aniksztejn, L; Ben Ari, Y; Cherubini, E; Sciancalepore, M | 1 |
| Cox, AJ; Lee, RK; Nitsch, RM; Wurtman, RJ | 1 |
| Eaton, SA; Salt, TE | 1 |
| Black, RT; Delahunty, TM; Jiang, JY; Lyeth, BG | 1 |
| Miles, R; Poncer, JC; Shinozaki, H | 1 |
| Cotman, CW; Miller, S; Romano, C | 1 |
| Blanc, E; Recasens, M; Vignes, M | 1 |
| Jope, RS; Kolasa, K | 1 |
| Collins, GG | 2 |
| Birse, EF; Eaton, SA; Jane, DE; Jones, PL; Pook, PC; Porter, RH; Roberts, PJ; Sunter, DC; Udvarhelyi, PM; Wharton, B | 1 |
| Catania, MV; Hollingsworth, Z; Penney, JB; Young, AB | 1 |
| Knöpfel, T; Staub, C; Vranesic, I | 1 |
| Bockaert, J; Cragoe, EJ; Dumuis, A; Fagni, L; Manzoni, O; Prézeau, L; Sebben, M | 1 |
| Casabona, G; Genazzani, AA; L'Episcopo, MR; Nicoletti, F; Shinozaki, H | 1 |
| Neale, JH; Saab, OH; Wroblewska, B; Wroblewski, JT | 1 |
| Jane, DE; Jones, PL; Pook, PC; Salt, TE; Sunter, DC; Watkins, JC | 1 |
| Naarala, J; Nykvist, P; Savolainen, K; Tuomala, M | 1 |
| Dykstra, CL; Gebhart, GF; Meller, ST | 1 |
| Klockgether, T; Turski, L | 1 |
| Bau, A; Faarup, P; Foged, C; Kanstrup, A; Suzdak, PD; Thomsen, C | 1 |
| Ajmal, M; Lang, CH | 1 |
| Bormann, J; Feigenspan, A | 1 |
| Ambrosini, A; Bresciani, L; Brunello, N; Fracchia, S; Racagni, G | 1 |
| Battaglia, G; Bruno, V; Copani, A; Leanza, G; Nicoletti, F; Pellitteri, R; Russo, A; Stanzani, S | 1 |
| Fibiger, HC; Taber, MT | 2 |
| Bockaert, J; Brabet, I; Curry, K; Gomeza, J; Joly, C; Pin, JP | 1 |
| Challiss, RA; Mistry, R; Wilke, R | 1 |
| Ikeda, T; Puro, DG | 1 |
| Bossu, JL; Gähwiler, BH; Gerber, U; Guérineau, NC | 2 |
| Barresi, V; Battaglia, G; Bruno, VM; Condorelli, DF; Copani, A; Nicoletti, F | 1 |
| Eveleth, D; Gutierrez, C; Lutz, D; Pettit, HO | 1 |
| Lachica, EA; Rubel, EW; Zirpel, L | 1 |
| el Manira, A; Grillner, S; Krieger, P; Tegnér, J | 1 |
| Haruta, H; Hicks, TP; Kamishita, T; Takahashi, MP; Tsumoto, T | 1 |
| Becker, T; de Barry, J; Gombos, G | 1 |
| Bridges, RJ; Chamberlin, AR; Cotman, CW; Miller, S | 1 |
| Lynch, MA; McGahon, B | 3 |
| Kato, N | 1 |
| Anwyl, R; O'Connor, JJ; Rowan, MJ | 2 |
| Meaney, MJ; Parent, A; Quirion, R; Rowe, W | 1 |
| Conn, PJ; Desai, MA; Kauer, JA; McBain, CJ | 1 |
| Miles, R; Poncer, JC | 1 |
| Devau, G; Lehouelleur, J; Sans, A | 1 |
| Gähwiler, BH; Gerber, U; Lüthi, A | 3 |
| Bigl, V; Grantyn, R; Rothe, T | 1 |
| Birrell, GJ; Gordon, MP; Marcoux, FW | 1 |
| Scholz, WK | 1 |
| Esposito, E; Gorbunov, N | 1 |
| Catt, KJ; Krsmanovic, LZ; Spergel, DJ; Stojilkovic, SS | 1 |
| Akaike, N; Harata, N; Shirasaki, T | 1 |
| Challiss, RA; Gray, DW; Mistry, R; Nahorski, SR | 1 |
| McDonald, JW; Schoepp, DD; Wright, RA | 1 |
| Hansson, E | 1 |
| Jane, DE; Jones, PL; Pook, PC; Tse, HW; Watkins, JC | 1 |
| Blackstone, CD; Candeo, P; Favaron, M; Manev, H; Milani, D | 1 |
| Cornell-Bell, AH; Kim, WT; Rioult, MG | 1 |
| Littman, L; Robinson, MB | 1 |
| Coffey, ET; Herrero, I; Nicholls, DG; Sánchez-Prieto, J; Sihra, TS | 1 |
| Slaughter, MM; Tian, N | 1 |
| Bevilacqua, JA; Downes, CP; Lowenstein, PR | 2 |
| Manzoni, OJ; Nicoll, RA; Weisskopf, MG | 1 |
| Ishida, M; Kwak, S; Miyamoto, M; Shinozaki, H | 1 |
| Collingridge, GL; Henley, JM; Irving, AJ; Seal, AJ | 1 |
| Hansen, L; Suzdak, PD; Thomsen, C | 1 |
| Challiss, RA; Nahorski, SR; Simpson, PB | 2 |
| Bernardi, G; Calabresi, P; Mercuri, NB; Pisani, A; Stefani, A | 1 |
| Dichter, MA; Maki, R; Robinson, MB | 1 |
| Bockaert, J; Chavis, P; Fagni, L; Shinozaki, H | 1 |
| Holmes, KH; Rainnie, DG; Shinnick-Gallagher, P | 1 |
| Berrino, L; Calderaro, V; D'Amico, M; Maione, S; Pizzirusso, A; Rossi, F; Vitagliano, S | 1 |
| Colwell, CS; Levine, MS | 2 |
| Burke, JP; Hablitz, JJ | 3 |
| Rodnight, R; Wofchuk, ST | 1 |
| Cherici, G; Leonard, P; Lombardi, G; Moroni, F; Pellegrini-Giampietro, DE; Pellicciari, R | 1 |
| Gabellini, N; Manev, H; Manev, RM | 2 |
| Cahusac, PM | 1 |
| Gorman, A; Griffiths, R | 1 |
| Alexander, SP; Cartmell, J; Kemp, JA; Kendall, DA; Shinozaki, H | 1 |
| Gähwiler, BH; Gerber, U; Guérineau, NC | 1 |
| Dougherty, PM; Paleček, J; Palečková, V; Willis, WD | 1 |
| Hayashi, Y; Higuchi, T; Kaba, H; Nakanishi, S | 1 |
| Baker, SR; Goldsworthy, J; Johnson, BG; Salhoff, CR; Schoepp, DD | 1 |
| Kataoka, K; Nakamura, Y; Ogata, T; Schubert, P; Shibata, T; Tsuji, K | 1 |
| Czyrak, A; Frankiewicz, T; Legutko, B; Pilc, A | 1 |
| Hartell, NA | 1 |
| Caciagli, F; Casabona, G; Ciccarelli, R; De Bernardis, E; Di Iorio, P; L'Episcopo, MR; Nicoletti, F; Shinozaki, H | 1 |
| Lebrun, F; Lerner-Natoli, M; Mayat, E; Réasens, M; Rondouin, G; Sassetti, I | 1 |
| Hölscher, C | 2 |
| Hiramatsu, M; Kadowaki, D; Kadoya, K; Kinno, I; Mori, A | 1 |
| Moises, HC; Womble, MD | 1 |
| Katz, PS; Levitan, IB | 1 |
| Ueda, T; Winter, HC | 2 |
| Alford, S; Dubuc, R | 1 |
| Aronica, E; Balázs, R; Condorelli, DF; Nicoletti, F | 1 |
| Cotman, CW; Kahle, JS | 1 |
| Glatt, BS; Littman, L; Robinson, MB | 1 |
| Arrighi, V; Fallacara, C; Memo, M; Pizzi, M; Spano, PF | 1 |
| Masu, M; Nakanishi, S; Takahashi, K; Tanabe, Y; Tsuchida, K | 1 |
| Cappel, E; Holler, T; Klein, J; Löffelholz, K | 1 |
| Fix, AS; Griffey, KI; Helton, DR; Johnson, JA; Schoepp, DD; Tizzano, JP | 1 |
| Knöpfel, T; Lingenhöhl, K; Olpe, HR | 1 |
| Bendali, N; Knöpfel, T; Lingenhöhl, K; Olpe, HR | 1 |
| Bashir, ZI; Bortolotto, ZA; Collingridge, GL; Davies, CH | 1 |
| Jane, D; Jones, A; Jones, P; Kemp, M; Pook, P; Roberts, P; Sunter, D; Udvarhelyi, P; Watkins, J | 1 |
| Brorson, JR; Gibbons, SJ; Holzwarth, JA; Miller, RJ; Philipson, LH | 1 |
| Beani, L; Bianchi, C; Caló, G; Ferraro, L; Menegale, M; Morari, M; Tomasini, C | 1 |
| Conn, PJ; Gereau, RW | 2 |
| Cahusac, PM; Taylor, KE | 1 |
| Fleetwood-Walker, SM; Mitchell, R; Munro, FE; Young, MR | 1 |
| Gallagher, JP; Johnson, KM; Lonart, G; Zheng, F | 1 |
| Chung, DS; Conn, PJ; Winder, DG | 1 |
| Andersen, CF; Frandsen, A; Schousboe, A; Suzdak, PD; Thomsen, C | 1 |
| Ikeda, M | 1 |
| Momiyama, A; Sladeczek, F; Takahashi, T | 1 |
| Ishida, M; Saitoh, T; Shinozaki, H | 1 |
| Birse, EF; Eaton, SA; Salt, TE; Sunter, DC; Udvarhelyi, PM; Watkins, JC; Wharton, B | 1 |
| Brown, DA; Caeser, M; Gähwiler, BH; Knöpfel, T | 1 |
| Jope, RS; Powers, R; Song, L | 1 |
| Gähwiler, BH; Gerber, U; Smart, TG; Xie, X | 1 |
| Bernardi, G; Calabresi, P; Mercuri, NB; Pisani, A | 2 |
| Koch, M | 1 |
| Alesiani, M; Cherici, G; Leonardi, P; Lombardi, G; Moroni, F; Pellicciari, R | 1 |
| Ben-Ari, Y; Otani, S; Roisin-Lallemand, MP | 1 |
| Candeo, P; Favaron, M; Gabellini, N; Manev, H; Manev, RM | 1 |
| Arban, R; Candeo, P; Favaron, M; Gabellini, N; Kozikowski, AP; Manev, H; Manev, RM | 1 |
| Alexander, SP; Cartmell, J; Kemp, JA; Kendall, DA | 1 |
| Opitz, T; Reymann, KG | 1 |
| Eaton, SA; Jane, DE; Jones, PL; Pook, PC; Porter, RH; Roberts, PJ; Salt, TE; Sunter, DC; Udvarhelyi, PM; Watkins, JC | 1 |
| Schoepp, DD | 1 |
| Ballyk, BA; Goh, JW; Musgrave, MA | 1 |
| Goh, JW; Musgrave, MA | 1 |
| Baba, A; Hashimoto, H; Saga, H | 1 |
| Dawson, TM; Fotuhi, M; Glatt, CE; Hwang, PM; Sharp, AH; Snyder, SH; von Krosigk, M | 1 |
| McCormick, DA; Wang, Z | 1 |
| Fidler, S; Lovinger, DM; Merritt, A; Tyler, E | 1 |
| Ballyk, BA; Goh, JW | 1 |
| Alexander, SP; Cartmell, J; Curtis, AR; Kemp, JA; Kendall, DA | 1 |
| Conn, PJ; Smith, T; Winder, DG | 1 |
| Birrell, GJ; Marcoux, FW | 1 |
| Porter, RH; Roberts, PJ | 1 |
| Collingridge, GL; Harvey, J | 1 |
| Ishida, M; Ohfune, Y; Saitoh, T; Shimamoto, K; Shinozaki, H | 1 |
| Fix, AS; McDonald, JW; Schoepp, DD; Tizzano, JP | 1 |
| Arban, R; Fadda, E; Lipartiti, M; Manev, H; Sautter, J; Savoini, G; Siliprandi, R | 1 |
| Averill, DB; Tsuchihashi, T | 1 |
| Netzeband, JG; Strahlendorf, HK; Strahlendorf, JC; Weathers, LB | 1 |
| Behnisch, T; Reymann, KG | 1 |
| De Bernardi, R; Ferro, F; Fontana, G; Gemignani, A; Raiteri, M | 1 |
| Childers, WS; Greenough, WT; Weiler, IJ | 1 |
| Gorbunov, NV | 1 |
| Bond, A; Lodge, D | 1 |
| Headley, PM; Jones, MW | 1 |
| Dickinson, T; Fleetwood-Walker, SM; Mitchell, R; Young, MR | 1 |
| Manahan-Vaughan, D; Reymann, KG | 2 |
| Chase, LA; Garlin, AB; Johnson, RL; Koerner, JF; Littman, L; Renzi, M; Robinson, MB | 1 |
| Jane, DE; Pittaway, K; Sunter, DC; Thomas, NK; Watkins, JC | 1 |
| Gallagher, JP; Hasuo, H; Zheng, F | 1 |
| Lovinger, DM; Tyler, EC | 1 |
| Anwyl, R; O'Mara, SM; Rowan, MJ | 1 |
| Darlington, CL; Smith, PF | 1 |
| Gruol, DL; Netzeband, JG | 1 |
| Carter, AJ; Kozikowski, AP; Opitz, T; Reymann, KG; Richter, P; Shinozaki, H | 1 |
| Morishita, W; Sastry, BR; Shew, TR | 1 |
| Cao, CQ; Evans, RH; Headley, PM; Udvarhelyi, PM | 1 |
| DaSilva, AM; Gillis, RA; McManigle, JE; Panico, WH | 1 |
| Berrino, L; Leyva, J; Maione, S; Pallotta, M; Rossi, F | 1 |
| Eriksson, G; Iverfeldt, K; Peterson, A; Walum, E | 1 |
| Dolan, L; Roberts, K; Tanimoto, M | 1 |
| Attwell, PJ; Bradford, HF; Croucher, MJ; Jane, DE; Kaura, S; Sigala, G; Watkins, JC | 1 |
| Hay, M; Lindsley, KA | 1 |
| Li, A; Nattie, EE | 1 |
| Pedarzani, P; Storm, JF | 1 |
| Gahwiler, BH; Scanziani, M; Thompson, SM | 1 |
| Arrighi, V; Consolandi, O; Galli, P; Memo, M; Pizzi, M; Spano, PF | 1 |
| Merlin, LR; Taylor, GW; Wong, RK | 1 |
| Choi, S; Lovinger, DM | 1 |
| Benz, A; Mennerick, S; Zorumski, CF | 1 |
| Ohno, M; Watanabe, S | 1 |
| Akhondzadeh, S; Stone, TW | 1 |
| Jope, RS; Kish, SJ; Li, PP; Pacheco, MA; Song, L; Warsh, JJ; Young, LT | 1 |
| Maiese, K; Swiriduk, M; TenBroeke, M | 1 |
| Gilbert, E; Grimwood, S; Hutson, PH; Ragan, CI | 1 |
| Burnett, JP; Johnson, BG; Mann, A; Mayne, NG; Schoenfelder, A; Schoepp, DD; Wermuth, CG; Wright, RA | 1 |
| Neuman, RS; Rahman, S | 1 |
| Kirischuk, S; Kostyuk, P; Verkhratsky, A; Voitenko, N | 1 |
| Schoepp, DD; Wright, RA | 1 |
| Ballerini, P; Battaglia, G; Caciagli, F; Ciccarelli, R; Di Iorio, P; Giuliani, P; Nicoletti, F; Poli, A | 1 |
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| Dolan, S; Nolan, AM | 1 |
| Albani-Torregrossa, S; Cattabeni, F; Colciaghi, F; De Graan, PN; Di Luca, M; Gardoni, F; Moroni, F; Pastorino, L; Pellegrini-Giampietro, DE | 1 |
| Blatow, M; Giuffrida, R; Monyer, H; van Hooft, JA | 1 |
| Cox, CL; Sherman, SM; Zhan, XJ | 1 |
| Calejesan, AA; Kim, SJ; Zhuo, M | 2 |
| Casabona, G; Copani, A; Di Giorgi Gerevini, V; Mutel, V; Nicoletti, F; Nicosia, A; Romano, C; Storto, M | 1 |
| Brumberg, JC; McCormick, DA; Nowak, LG | 1 |
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| Balcar, VJ; FitzGibbon, T; Lawrance, ML; Pliss, L; Shave, E; Stastny, F | 1 |
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| Hounsgaard, J; Noraberg, J; Perrier, JF; Simon, M | 1 |
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| Chen, J; Heinke, B; Sandkühler, J | 1 |
| Adamchik, Y; Baskys, A | 1 |
| Battaglia, G; Calogero, A; de Grazia, U; Felli, MP; Frati, L; Gulino, A; Maroder, M; Nicoletti, F; Ragona, G; Screpanti, I; Storto, M | 1 |
| Cox, CL; Sherman, SM | 1 |
| Oja, SS; Saransaari, P | 1 |
| Zilberter, Y | 1 |
| Dutar, P; Perkel, DJ; Petrozzino, JJ; Schmidt, MF; Vu, HM | 1 |
| Barbara, JG; Lasser-Ross, N; Nakamura, K; Nakamura, T; Ross, WN; Sandler, VM | 1 |
| Bennett, HJ; Semba, K; White, TD | 1 |
| Ruscheweyh, R; Sandkühler, J | 1 |
| Bellone, C; Cattabeni, F; Di Luca, M; Gardoni, F | 1 |
| Donato, R; Nistri, A | 1 |
| Gerber, G; Kojić, L; Randić, M; Zhong, J | 1 |
| Hasser, EM; Hay, M; Hoang, CJ; Price, EM | 1 |
| Aoki, F; Grillner, S; Wannier, T | 1 |
| Akaike, N; Katsurabayashi, S; Kubota, H; Rhee, JS; Wang, ZM | 1 |
| Nagy, F; Voisin, DL | 1 |
| Ellis, EF; Floyd, CL; Rzigalinski, BA; Sitterding, HA; Weber, JT; Willoughby, KA | 1 |
| Aramakis, VB; Ashe, JH; Bandrowski, AE; Moore, SL | 1 |
| Bear, M; Blakemore, C; Hannan, AJ; Huber, KM; Katsnelson, A; Kim, D; Kind, PC; Roder, J; Shin, HS; Vitalis, T | 1 |
| Martin, SJ | 1 |
| Ashe, JH; Bandrowski, AE; Crawford, CA | 1 |
| Inoue, N; Nakayama, T; Soga, TM | 1 |
| Hamilton, SE; Nathanson, NM | 1 |
| Blaabjerg, M; Bonde, C; Kristensen, BW; Zimmer, J | 1 |
| Gleason, EL; Kreimborg, KM; Lester, ML; Medler, KF | 1 |
| de Almeida, OM; de Mello, FG; de Mello, MC; Gardino, PF; Kubrusly, RC; Loureiro-Dos-Santos, NE; Reis, RA | 1 |
| Bennett, MV; Lan, J; Opitz, T; Skeberdis, VA; Zheng, X; Zukin, RS | 1 |
| Haworth, RA; Schomberg, SL; Su, G; Sun, D | 1 |
| Morsette, DJ; Sidorowicz, H; Sladek, CD | 1 |
| Bennett, MV; Jover, T; Lan , JY; Skeberdis, VA; Zheng, X; Zukin, RS | 1 |
| Hirai, H | 1 |
| Chamberlain, M; Johnson, MP; Kelly, G | 1 |
| Castro-Moure, F; Goshgarian, HG; Zhou, SY | 1 |
| Hirose, K; Iino, M; Kakizawa, S; Okubo, Y | 1 |
| Albani-Torregrossa, S; Attucci, S; Moroni, F; Pellegrini-Giampietro, DE | 1 |
| Crepel, F; Daniel, H; Levenes, C | 1 |
| Ransom, BR; Sontheimer, H; Ye, ZC | 1 |
| Abe, I; Fujishima, M; Kagiyama, S; Matsumura, K; Phillips, MI; Tsuchihashi, T | 1 |
| Luo, L; Qu, B; Sun, Y; Wang, T; Yuan, F; Zhang, L | 1 |
| Akaike, N; Doi, A; Ishibashi, H; Jinno, S; Kosaka, T | 1 |
| Cai, Z; Lin, S; Rhodes, PG | 1 |
| Blethyn, KL; Cope, DW; Crunelli, V; Hughes, SW | 1 |
| Caguioa-Aquino, JN; Gruol, DL; Netzeband, JG; Schneeloch, JR; Trotter, C | 1 |
| Abarca, J; Bustos, G; Campusano, JM; Forray, MI; Gysling, K | 1 |
| Duvilanski, B; Lasaga, M; Pampillo, M; Seilicovich, A; Theas, S | 1 |
| Chiang, AS; Lin, SC; Liu, HP; Pszczolkowski, MA | 1 |
| Akiyama, M; Isoda, Y; Kamihara, K; Kuboki, A; Ohira, S | 1 |
| Hornby, TG; McDonagh, JC; Reinking, RM; Stuart, DG | 1 |
| Celis, ME; Duvilanski, BH; Lasaga, M; Pampillo, M; Scimonelli, T; Seilicovich, A | 1 |
| Meeker, RB | 1 |
| Lasser-Ross, N; Nakamura, K; Nakamura, T; Ross, WN | 1 |
| Johnson, SW; Zheng, F | 2 |
| Boldyrev, AA; Bulygina, ER; Lyapina, LY | 1 |
| Bradley, DM; Hayes, CJ; Mapitse, R; Thomson, NM | 1 |
| Chan, JY; Lo, WC; Tseng, CJ; Tung, CS | 1 |
| Kudo, Y; Morita, M; Tsuchiya, R; Yoshiki, F | 1 |
| Woody, CD | 1 |
| Brown, JJ; Bushman, SM; Pszczolkowski, MA; Zahand, A | 1 |
| Bräuner-Osborne, H; Conti, P; De Amici, M; De Micheli, C; Madsen, U; Toma, L | 1 |
| Blanchard, JA; Fu, MC; Gibson, DA; Harris, BR; Hart, SR; Holley, RC; Littleton, JM; Pedigo, NW; Prendergast, MA; Rogers, DT | 1 |
| Maeda, J; Okauchi, T; Semba, J; Suhara, T | 1 |
| Antunes, VR; Machado, BH | 1 |
| Jankovic, SM; Milovanovic, DR | 1 |
| Croucher, MJ; Lee, JJ | 1 |
| Hong, YM; Jun, K; Kim, DY; Kim, YI; Lee, S; Park, D; Shin, HS | 1 |
| Fiumana, E; Jaggar, JH; Leffler, CW; Parfenova, H | 1 |
| Larkum, ME; Lasser-Ross, N; Nakamura, T; Ross, WN; Watanabe, S | 1 |
| Boldyrev, A; Bulygina, E; Gerasimova, O | 1 |
| Sitniewska, EM; Wiśniewska, RJ; Wiśniewski, K | 1 |
| Chappell, RL; Rosenstein, FJ | 1 |
| Davies, R; Reynolds, AM; Robbins, J; Treseder, S | 1 |
| Kudo, Y; Matsumoto, N; Miyakawa, H; Morita, M; Tsuchiya, R; Yoshida, Y | 2 |
| Alexander, JS; Chi, A; Elrod, JW; Hines, I; Houghton, J; Jackson, TH; Jawahar, A; Long, A; Minagar, A; Nanda, A; Sharp, CD; Warren, A | 1 |
| Barbanel, G; Kamenka, JM; Laplanche, L; Michaud, M | 1 |
| Cox, CL; Reichova, I; Sherman, SM | 1 |
| Ameda, K; Kakizaki, H; Koyanagi, T; Shibata, T; Tanaka, H | 1 |
| Alreja, M; Hajszan, T; Leranth, C; Wu, M | 1 |
| Carmignoto, G; Fellin, T; Gobbo, S; Pozzan, T; Sebelin, A; Zonta, M | 1 |
| Casolini, P; Catalani, A; Cinque, C; Di Giorgi Gerevini, V; Maccari, S; Melchiorri, D; Ngomba, RT; Nicoletti, F; Zuena, AR | 1 |
| Aránguez, I; Arce, C; Del Campo, AB; Figueroa, S; González, MP; López, E; Oset-Gasque, MJ | 1 |
| Chianca, DA; Dragon, DN; Lin, LH; Talman, WT | 1 |
| Antunes, VR; Bonagamba, LG; Machado, BH | 1 |
| Fitarelli, D; Horn, J; Kommers, T; Oliveira, D; Oppelt, D; Rodnight, R; Wofchuk, S | 1 |
| Lu, Y; Rubel, EW | 1 |
| Arvanian, VL; Mendell, LM; Motin, V | 1 |
| Bonev, AD; Filosa, JA; Nelson, MT | 1 |
| Chi, OZ; Liu, X; Weiss, HR | 1 |
| Andrianov, GN; Demêmes, D; Puyal, J; Raymond, J; Ryzhova, IV; Ventéo, S | 1 |
| Boeck, CR; Bronzatto, MJ; Jardim, FM; Kroth, EH; Souza, DO; Vendite, D | 1 |
| Abarca, J; Andrés, ME; Bustos, G; Campusano, JM; Magendzo, K; Tapia-Arancibia, L | 1 |
| Connors, BW; Landisman, CE | 1 |
| Blethyn, KL; Cope, DW; Crunelli, V; Hughes, SW; Tóth, TI | 1 |
| Calixto, JB; Gadotti, VM; Paszcuk, AF; Rodrigues, AL; Santos, AR; Tibola, D | 1 |
| Blethyn, KL; Cope, DW; Crunelli, V; Hughes, SW; Tsomaia, V; Zhu, L | 1 |
| Kanumilli, S; Roberts, PJ | 1 |
| Hayashi, K; Ichitani, Y; Yoshihara, T | 1 |
| Andrianov, GN; Nozdrachev, AD; Ryzhova, IV | 1 |
| Grau, Y; Hamasaka, Y; Helfrich-Förster, C; Nässel, DR; Parmentier, ML; Rieger, D | 1 |
| Jakovljevic, M; Jankovic, SM; Jankovic, SV; Milovanovic, D; Stojadinovic, D | 1 |
| Rao, SP; Sikdar, SK | 1 |
| Bogun, M; Fricke, O; Kow, LM; Pfaff, DW | 1 |
| Larkum, ME; Lasser-Ross, N; Rhodes, P; Ross, WN; Watanabe, S | 1 |
| Blanco, VM; Filosa, JA; Stern, JE | 1 |
| Martina, M; Mugnaini, E; Nunzi, MG; Russo, MJ; Yau, HJ | 1 |
| Dietrich, D; Wostrack, M | 1 |
| Bhatt, D; Chung, WY; Cooper, RL; Lee, JY | 1 |
| Chen, Y; Ma, Y; McNearney, TA; Taglialatela, G; Westlund, KN; Yin, H; Zhang, WR | 1 |
| Beltramo, M; Brusa, R; Lozza, G; Mancini, I; Petrò, R; Reggiani, A; Scandroglio, P | 1 |
| Dong, LP; Han, M; Wang, TY; Xu, LX; Yuan, F | 1 |
| Bartoletti, TM; Thoreson, WB | 1 |
| He, L; Linden, DJ; Sapirstein, A | 1 |
| Beka, TI; Boas, DA; Chen, J; Cheng, Q; Cui, J; Dale, AM; Devor, A; Einevoll, GT; Gratiy, SL; MacDonald, CL; Masliah, E; Nizar, K; Reznichenko, L; Saisan, PA; Sakadzić, S; Silva, GA; Sridhar, VB; Steed, TC; Tian, P; Uhlirova, H; Weldy, KL | 1 |
| Charles, JR; Duva, MA; Lara, RL; Ramirez, GJ; Stanley, BG; Yang, CR | 1 |
| Amakhin, DV; Popov, VA; Veselkin, NP | 1 |
| Aira, Z; Azkue, JJ; Barrenetxea, T; Buesa, I; Martínez, E | 1 |
| Baldridge, WH; Blandford, SN | 1 |
6 review(s) available for 1-amino-1,3-dicarboxycyclopentane and cycloleucine
| Article | Year |
|---|---|
A metabotropic L-glutamate receptor agonist: pharmacological difference between rat central neurones and crayfish neuromuscular junctions.
Topics: Amino Acids, Dicarboxylic; Animals; Astacoidea; Cycloleucine; Hippocampus; Membrane Potentials; Motor Neurons; Neuromuscular Junction; Oocytes; Phosphatidylinositols; Rats; Receptors, Glutamate; Synaptosomes | 1992 |
Multiple excitatory amino acid receptor regulation of intracellular Ca2+. Implications for aging and Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Brain Chemistry; Calcium; Cycloleucine; Humans; Phosphatidylinositols; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Roles of metabotropic glutamate receptors in brain plasticity and pathology.
Topics: Animals; Astrocytes; Brain; Brain Diseases; Carbachol; Cells, Cultured; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; In Vitro Techniques; Mice; N-Methylaspartate; Neuronal Plasticity; Phosphatidylinositols; Receptors, Metabotropic Glutamate; Signal Transduction | 1995 |
Glutamate-induced calcium signaling in astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Calcium; Cell Communication; Cell Compartmentation; Cells, Cultured; Cycloleucine; Glutamic Acid; Hippocampus; Humans; Inositol 1,4,5-Trisphosphate; Models, Neurological; Nerve Tissue Proteins; Rats; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Second Messenger Systems; Videodisc Recording | 1994 |
The biochemical pharmacology of metabotropic glutamate receptors.
Topics: Animals; Brain; Cyclic AMP; Cycloleucine; Hydrolysis; Molecular Structure; Phosphatidylinositols; Rats; Receptors, Glutamate | 1993 |
Metabotropic glutamate receptors control gating of spike transmission in the hippocampus area CA1.
Topics: Animals; Cycloleucine; Electroencephalography; Hippocampus; Humans; Interneurons; Long-Term Potentiation; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2002 |
831 other study(ies) available for 1-amino-1,3-dicarboxycyclopentane and cycloleucine
| Article | Year |
|---|---|
Modulation of AMPA and NMDA responses in rat spinal dorsal horn neurons by trans-1-aminocyclopentane-1,3-dicarboxylic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Electrophysiology; Ibotenic Acid; N-Methylaspartate; Neurons; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Spinal Cord | 1992 |
Preferential activation of [3H]phorbol-12,13-dibutyrate binding by AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) in neonatal striatal cell cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Binding Sites; Cells, Cultured; Corpus Striatum; Cycloleucine; Glial Fibrillary Acidic Protein; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Phorbol 12,13-Dibutyrate; Phosphopyruvate Hydratase; Rats; Rats, Inbred F344 | 1992 |
Activation of a metabotropic excitatory amino acid receptor potentiates A2b adenosine receptor-stimulated cyclic AMP accumulation.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biotransformation; Cerebral Cortex; Cyclic AMP; Cycloleucine; Female; Guinea Pigs; Ibotenic Acid; In Vitro Techniques; Inositol Phosphates; Male; N-Methylaspartate; Receptors, Amino Acid; Receptors, Purinergic; Vasodilator Agents | 1992 |
Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Arginine; Cycloleucine; Hemoglobins; Hydroxylamine; Hydroxylamines; Hyperalgesia; Ibotenic Acid; Injections, Spinal; Kainic Acid; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Spinal Cord; Time Factors | 1992 |
Inhibition of cyclic AMP formation by a selective metabotropic glutamate receptor agonist.
Topics: Animals; Colforsin; Cyclic AMP; Cycloleucine; Hippocampus; In Vitro Techniques; Isomerism; Male; Osmolar Concentration; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
Inhibition of forskolin-stimulated cyclic AMP formation by 1-aminocyclopentane-trans-1,3-dicarboxylate in guinea-pig cerebral cortical slices.
Topics: Amino Acids; Animals; Cerebral Cortex; Colforsin; Cyclic AMP; Cycloleucine; Guinea Pigs; In Vitro Techniques; Receptors, Amino Acid; Receptors, Cell Surface; Stereoisomerism | 1992 |
Trans-ACPD selectively inhibits excitability of hippocampal CA1 neurones.
Topics: Animals; Cycloleucine; Evoked Potentials; Hippocampus; In Vitro Techniques; Neurons; Rats; Synaptic Transmission | 1992 |
Long-lasting enhancement of metabotropic excitatory amino acid receptor-mediated polyphosphoinositide hydrolysis in the amygdala/pyriform cortex of deep prepiriform cortical kindled rats.
Topics: Amygdala; Animals; Cerebral Cortex; Cycloleucine; Electric Stimulation; Hydrolysis; Ibotenic Acid; Isomerism; Kindling, Neurologic; Limbic System; Male; Neurotoxins; Phosphatidylinositol Phosphates; Phosphatidylinositols; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Seizures | 1992 |
Burst firing of rat septal neurons induced by 1S,3R-ACPD requires influx of extracellular calcium.
Topics: Animals; Calcium; Calcium Channel Blockers; Cycloleucine; In Vitro Techniques; Male; Membrane Potentials; Neurons; Nickel; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Second Messenger Systems; Tetrodotoxin | 1992 |
Metabotropic glutamate receptor activation produces extrapyramidal motor system activation that is mediated by striatal dopamine.
Topics: Animals; Corpus Striatum; Cycloleucine; Dopamine; Dopamine Antagonists; Extrapyramidal Tracts; Haloperidol; Male; Motor Activity; Neurotoxins; Potassium; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
Evidence for metabotropic excitatory amino acid receptor heterogeneity: developmental and brain regional studies.
Topics: Aging; Alanine; Animals; Animals, Newborn; Brain; Cycloleucine; Drug Interactions; Male; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Tissue Distribution | 1992 |
L-glutamate and acetylcholine mobilise Ca2+ from the same intracellular pool in cerebellar granule cells using transduction mechanisms with different Ca2+ sensitivities.
Topics: Acetylcholine; Animals; Calcium; Cerebellar Cortex; Cycloleucine; Glutamates; Pertussis Toxin; Rats; Receptors, Glutamate; Receptors, Muscarinic; Receptors, Neurotransmitter; Signal Transduction; Virulence Factors, Bordetella | 1992 |
Inhibition of the phospholipase C-linked metabotropic glutamate receptor by 2-amino-3-phosphonopropionate is dependent on extracellular calcium.
Topics: Alanine; Animals; Calcium; Chromatography, High Pressure Liquid; Cycloleucine; Extracellular Matrix; Glutamates; GTP-Binding Proteins; Hippocampus; Inositol 1,4,5-Trisphosphate; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Time Factors; Type C Phospholipases | 1992 |
2-Amino-3-phosphonopropionate fails to block postsynaptic effects of metabotropic glutamate receptors in rat hippocampal neurones.
Topics: Action Potentials; Alanine; Animals; Cycloleucine; Female; Glutamates; Hippocampus; Male; Membrane Potentials; Neurons; Neurotoxins; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
Metabotropic glutamate receptors and neuronal toxicity.
Topics: Amino Acids, Diamino; Animals; Cells, Cultured; Cerebellum; Cyanobacteria Toxins; Cycloleucine; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1992 |
Developmental changes in the modulation of cyclic AMP formation by the metabotropic glutamate receptor agonist 1S,3R-aminocyclopentane-1,3-dicarboxylic acid in brain slices.
Topics: Aging; Animals; Animals, Newborn; Brain; Colforsin; Cyclic AMP; Cycloleucine; Dose-Response Relationship, Drug; Hippocampus; Hypothalamus; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
Trans-ACPD inhibits cAMP formation via a pertussis toxin-sensitive G-protein.
Topics: Animals; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Cycloleucine; Dose-Response Relationship, Drug; GTP-Binding Proteins; Pertussis Toxin; Virulence Factors, Bordetella | 1992 |
Activation of glutamate metabotropic receptors induces long-term potentiation.
Topics: Animals; Cycloleucine; Hippocampus; In Vitro Techniques; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1992 |
Coactivation of metabotropic glutamate receptors and of voltage-gated calcium channels induces long-term depression in cerebellar Purkinje cells in vitro.
Topics: Animals; Azasteroids; Calcium Channels; Cycloleucine; Evoked Potentials; In Vitro Techniques; Ion Channel Gating; Neuronal Plasticity; Oxidoreductases; Pregnanediones; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synaptic Transmission | 1992 |
Synaptic enhancement induced by NMDA and Qp receptors and presynaptic activity.
Topics: Animals; Axons; Cycloleucine; Electrophysiology; Evoked Potentials; Hippocampus; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurotoxins; Oxadiazoles; Pyramidal Tracts; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1992 |
Metabotropic glutamate receptor agonists reduce epileptiform activity in the rat cortex.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cycloleucine; Epilepsy; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Quisqualic Acid; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Synapses | 1992 |
Multiple metabotropic glutamate receptors regulate hippocampal function.
Topics: Alanine; Animals; Cycloleucine; Electric Stimulation; Electrophysiology; Hippocampus; Hydrolysis; Male; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1992 |
1-Aminocyclopentane-trans-1,3-dicarboxylic acid induces glutamine synthetase activity in cultured astrocytes.
Topics: Amino Acids; Animals; Astrocytes; Cells, Cultured; Cycloleucine; Glutamate-Ammonia Ligase; Microscopy, Phase-Contrast; Receptors, Amino Acid; Receptors, Cell Surface | 1992 |
Potentiation of mossy fiber-evoked EPSPs in turtle cerebellar Purkinje cells by the metabotropic glutamate receptor agonist 1S,3R-ACPD.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Cycloleucine; Dose-Response Relationship, Drug; Evoked Potentials; Glutamates; In Vitro Techniques; Nerve Fibers; Neurotoxins; Purkinje Cells; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Turtles | 1992 |
[Effect of trans-ACPD, a specific agonist of glutamate interacting with metabotropic receptors, on synaptic transmission in the rat hippocampus].
Topics: Animals; Cycloleucine; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Membrane Potentials; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1992 |
Activation of metabotropic glutamate receptors in the hippocampus increases cyclic AMP accumulation.
Topics: Alanine; Animals; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Male; Neurotoxins; Osmolar Concentration; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
Excitatory amino acid-induced phosphoinositide turnover in guinea pig cerebral cortical slices: selective enhancement by spermine of the response to DL-1-aminocyclopentane-trans-1,3-dicarboxylate.
Topics: Adrenergic alpha-Antagonists; Alkaloids; Amino Acids; Animals; Calcium; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Female; Glutamates; Guinea Pigs; Hydrolysis; Male; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Piperidines; Polyamines; Protein Kinase C; Receptors, Amino Acid; Receptors, Cell Surface; Spermine; Staurosporine | 1992 |
Metabotropic glutamate receptors are required for the induction of long-term potentiation.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Alanine; Aminobutyrates; Animals; Calcium; Cycloleucine; Dose-Response Relationship, Drug; Egtazic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Male; Microinjections; Neurons; Organ Culture Techniques; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission; Time Factors | 1992 |
Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Alanine; Alkaloids; Animals; Cell Membrane; Cells, Cultured; Colforsin; Corpus Striatum; Cycloleucine; Glutamates; Glutamic Acid; GTP-Binding Proteins; In Vitro Techniques; Mice; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Signal Transduction; Staurosporine; Virulence Factors, Bordetella | 1992 |
Activation of quisqualate metabotropic receptors reduces glutamate and GABA-mediated synaptic potentials in the rat striatum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Cycloleucine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Neurotoxins; Quinoxalines; Rats; Receptors, AMPA; Receptors, Neurotransmitter; Synapses | 1992 |
Trans-ACPD and L-APB presynaptically inhibit excitatory glutamatergic transmission in the basolateral amygdala (BLA).
Topics: Aminobutyrates; Amygdala; Animals; Cycloleucine; Electrodes; Evoked Potentials; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 1992 |
Metabotropic glutamate receptor agonists potentiate a slow afterdepolarization in CNS neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cycloleucine; Evoked Potentials; Glutamates; Ibotenic Acid; In Vitro Techniques; Male; Membrane Potentials; Neurons; Prosencephalon; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate | 1992 |
Metabotropic receptor mediated afterdepolarization in neocortical neurons.
Topics: Action Potentials; Animals; Cerebral Cortex; Cycloleucine; Glutamates; Glutamic Acid; In Vitro Techniques; Microelectrodes; Neuromuscular Depolarizing Agents; Neurons; Quisqualic Acid; Rats; Receptors, Glutamate | 1992 |
Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation.
Topics: 4-Aminopyridine; Animals; Arachidonic Acid; Calcium; Cycloleucine; Dose-Response Relationship, Drug; Exocytosis; Feedback; Glutamates; Glutamic Acid; Male; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Synaptosomes | 1992 |
Trans-ACPD-induced phosphoinositide hydrolysis and modulation of hippocampal pyramidal cell excitability do not undergo parallel developmental regulation.
Topics: Action Potentials; Animals; Cycloleucine; Female; Glutamates; Glutamic Acid; Hippocampus; Hydrolysis; In Vitro Techniques; Male; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1992 |
Norepinephrine reverses N-methyl-D-aspartate-mediated inhibition of long-term potentiation in rat hippocampal slices.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cycloleucine; Hippocampus; In Vitro Techniques; Isoproterenol; Male; Methoxamine; N-Methylaspartate; Neuronal Plasticity; Norepinephrine; Phenylephrine; Rats | 1992 |
The expression of presynaptic t-ACPD receptor in rat cerebellum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cerebellum; Cycloleucine; Dendrites; Evoked Potentials; Fluorescent Dyes; Heterocyclic Compounds, 3-Ring; In Vitro Techniques; Membrane Potentials; Neurotoxins; Purkinje Cells; Quinoxalines; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Receptors, Neurotransmitter; Synapses | 1992 |
3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Animals; Cycloleucine; Egtazic Acid; Glycine; Hippocampus; In Vitro Techniques; Male; Oocytes; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Resorcinols; RNA, Messenger; Xenopus | 1992 |
Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Drug Synergism; Glutamates; Glutamic Acid; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Myocardial Contraction; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synapses; Synaptic Transmission | 1992 |
Both enantiomers of 1-aminocyclopentyl-1,3-dicarboxylate are full agonists of metabotropic glutamate receptors coupled to phospholipase C.
Topics: Animals; Calcium; Cell Differentiation; Cells, Cultured; Cerebellum; Corpus Striatum; Cycloleucine; Cytoplasmic Granules; Female; Inositol Phosphates; Intracellular Fluid; Mice; Neurons; Oocytes; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA; Stereoisomerism; Stimulation, Chemical; Type C Phospholipases; Xenopus | 1992 |
The metabotropic excitatory amino acid receptor agonist 1S,3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cycloleucine; Drug Synergism; Ibotenic Acid; In Vitro Techniques; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid | 1992 |
Two pathways of cyclic GMP production through glutamate receptor-mediated nitric oxide synthesis.
Topics: 1-Methyl-3-isobutylxanthine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cyclic GMP; Cycloleucine; Ibotenic Acid; In Vitro Techniques; Male; Nitric Oxide; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Glutamate | 1992 |
Actions of a metabotropic glutamate receptor agonist in immature and adult rat cerebellum.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cerebellum; Cycloleucine; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Antagonists; Ibotenic Acid; In Vitro Techniques; Purkinje Cells; Quinoxalines; Rats; Receptors, Glutamate | 1992 |
4C3HPG (RS-4-carboxy-3-hydroxyphenylglycine), a weak agonist at metabotropic glutamate receptors, occludes the action of trans-ACPD in hippocampus.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Ion Channels; Rats; Receptors, Glutamate | 1992 |
Activation of metabotropic receptors has a neuroprotective effect in a rodent model of focal ischaemia.
Topics: Animals; Cerebral Arteries; Cycloleucine; Disease Models, Animal; Ischemic Attack, Transient; Male; Mice; Receptors, Glutamate | 1992 |
Activation of the glutamate metabotropic receptor protects retina against N-methyl-D-aspartate toxicity.
Topics: Animals; Cycloleucine; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glutamate; Retina | 1992 |
Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage.
Topics: Animals; Behavior, Animal; Biotransformation; Cell Death; Cycloleucine; GTP-Binding Proteins; Hippocampus; Male; Neuronal Plasticity; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Seizures | 1992 |
Developmental changes of EAA metabotropic receptor activity in rat cerebellum.
Topics: Aging; Animals; Cerebellum; Cycloleucine; Hydrolysis; Inositol; Inositol Phosphates; Rats; Rats, Wistar; Receptors, Amino Acid | 1992 |
Effects of a metabotropic glutamate agonist, trans-ACPD, on cortical epileptiform activity.
Topics: Animals; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Epilepsy; Glutamates; In Vitro Techniques; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Stereoisomerism | 1992 |
Trans-ACPD induces a slow post-stimulus inward tail current (IADP) in guinea-pig olfactory cortex neurones in vitro.
Topics: Animals; Cerebral Cortex; Cycloleucine; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Neurons; Stereoisomerism | 1992 |
Metabotropic excitatory amino acid receptor activation stimulates phospholipase D in hippocampal slices.
Topics: Animals; Autoradiography; Cycloleucine; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Hippocampus; Ibotenic Acid; Organ Culture Techniques; Phospholipase D; Quisqualic Acid; Receptors, Amino Acid | 1992 |
Role of metabotropic glutamate (ACPD) receptors at the parallel fiber-Purkinje cell synapse.
Topics: Afferent Pathways; Animals; Cerebellum; Cycloleucine; Electric Stimulation; Evoked Potentials; Female; Glutamates; In Vitro Techniques; Male; Membrane Potentials; Nerve Fibers; Neurotoxins; Purkinje Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synapses; Tetrodotoxin | 1992 |
Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Calcium; Cycloleucine; Egtazic Acid; Gene Library; Glutamates; Ibotenic Acid; Kainic Acid; Membrane Potentials; Molecular Sequence Data; Neurotoxins; Oligodeoxyribonucleotides; Oligonucleotide Probes; Oocytes; Polymerase Chain Reaction; Receptors, Glutamate; Restriction Mapping; Xenopus | 1992 |
1S,3R-ACPD-sensitive (metabotropic) [3H]glutamate receptor binding in membranes.
Topics: Animals; Cerebral Cortex; Cycloleucine; In Vitro Techniques; Kinetics; Membranes; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1992 |
Evidence for presynaptic depression of monosynaptic excitation in neonatal rat motoneurones by (1S,3S)- and (1S,3R)-ACPD.
Topics: Animals; Animals, Newborn; Cycloleucine; Isomerism; Motor Neurons; Rats; Spinal Nerve Roots; Synapses | 1992 |
Trans-ACPD depresses synaptic transmission in the hippocampus.
Topics: Animals; Cycloleucine; Evoked Potentials; Hippocampus; In Vitro Techniques; Rats; Synapses; Synaptic Transmission | 1991 |
Role for ionotropic and metabotropic receptors in quisqualate-stimulated inositol polyphosphate accumulation in rat cerebral cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cerebral Cortex; Cycloleucine; Ibotenic Acid; In Vitro Techniques; Inositol Phosphates; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Neurotransmitter | 1991 |
Metabotropic receptor-mediated regulation of cytoplasmic free calcium in cultured cerebellar granule cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Carbachol; Cells, Cultured; Cerebellum; Cycloleucine; Cytoplasm; Ibotenic Acid; Kinetics; N-Methylaspartate; Neurotoxins; Piperidines; Quisqualic Acid; Receptors, Neurotransmitter | 1991 |
Trans-ACPD enhances long-term potentiation in the hippocampus.
Topics: Animals; Cycloleucine; Electrophysiology; Glutamates; Hippocampus; In Vitro Techniques; Neurotoxins; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1991 |
Trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) decreases synaptic excitation in rat striatal slices through a presynaptic action.
Topics: Animals; Corpus Striatum; Cycloleucine; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neurotoxins; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1991 |
Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Animals; Carbachol; Cells, Cultured; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Isoquinolines; Mice; N-Methylaspartate; Neurons; Neurotoxins; Piperazines; Protein Kinase C; Receptors, Glutamate; Receptors, Neurotransmitter; Sulfonamides | 1991 |
Effects of ACPD and AP3 on parallel-fibre-mediated EPSPs of Purkinje cells in cerebellar slices in vitro.
Topics: Alanine; Animals; Calcium; Cerebellum; Cycloleucine; Evoked Potentials, Somatosensory; In Vitro Techniques; Purkinje Cells; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Neurotransmitter | 1991 |
Intrastriatal injection of a selective metabotropic excitatory amino acid receptor agonist induces contralateral turning in the rat.
Topics: Animals; Behavior, Animal; Corpus Striatum; Cycloleucine; Dose-Response Relationship, Drug; Locomotion; Male; Phosphatidylinositols; Pipecolic Acids; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Tritium | 1991 |
Comparison of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD)- and 1R,3S-ACPD-stimulated brain phosphoinositide hydrolysis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cycloleucine; Hydrolysis; Ibotenic Acid; Kainic Acid; Male; Membranes; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Stimulation, Chemical | 1991 |
A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebral Cortex; Cycloleucine; Embryo, Mammalian; Glutamates; Ibotenic Acid; Kainic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Receptors, Glutamate; Receptors, Neurotransmitter; Tetrodotoxin | 1991 |
The effects of trans-ACPD on long-term potentiation in the rat hippocampal slice.
Topics: Animals; Cycloleucine; Electric Stimulation; Hippocampus; Membrane Potentials; Neurotoxins; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Second Messenger Systems; Sphingosine | 1991 |
Metabotropic receptor-mediated long-term potentiation in rat hippocampal slices.
Topics: Animals; Cycloleucine; Hippocampus; In Vitro Techniques; Membrane Potentials; Neuronal Plasticity; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Time Factors | 1991 |
Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus.
Topics: Aminobutyrates; Animals; Cycloleucine; Electrophysiology; Hippocampus; In Vitro Techniques; Neurotoxins; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1991 |
Glutamate mediates a slow synaptic response in hippocampal slice cultures.
Topics: Animals; Cycloleucine; Electric Stimulation; Electrophysiology; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Synapses | 1991 |
Agonists selective for phosphoinositide-coupled receptors sensitize neurons to depolarization by L-2-amino-4-phosphonobutanoic acid (L-AP4).
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Animals; Carbachol; Cerebral Cortex; Cycloleucine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Neuromuscular Depolarizing Agents; Neurons; Norepinephrine; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear | 1991 |
Differential regulation of cerebellar granule neurons by two types of quisqualate receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cerebellar Cortex; Cycloleucine; Diltiazem; Glutaminase; Ibotenic Acid; Ion Channel Gating; L-Lactate Dehydrogenase; Neuronal Plasticity; Neurons; Nifedipine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Neurotransmitter | 1991 |
beta-N-methylamino-L-alanine is a low-affinity agonist of metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids, Diamino; Animals; Carbachol; Cells, Cultured; Corpus Striatum; Cyanobacteria Toxins; Cycloleucine; Dizocilpine Maleate; Embryo, Mammalian; Glutamates; Inositol; Inositol Phosphates; Kinetics; Mice; Neurons; Neurotoxins; Phorbol 12,13-Dibutyrate; Quinoxalines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
Trans-ACPD reduces multiple components of synaptic transmission in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cycloleucine; Electrophysiology; Hippocampus; In Vitro Techniques; Male; Quinoxalines; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Synapses; Synaptic Transmission | 1991 |
Selective activation of oscillatory currents by trans-ACPD in rat brain mRNA-injected Xenopus oocytes and their blockade by NMDA.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Cycloleucine; Ion Channels; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; RNA, Messenger; Xenopus | 1990 |
Single channel properties of the N-methyl-D-aspartate receptor channel using NMDA and NMDA agonists: on-cell recordings.
Topics: Animals; Cells, Cultured; Cycloleucine; Electrophysiology; Hippocampus; Ion Channels; Kinetics; Magnesium; Membrane Potentials; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Temperature | 1990 |
Selective activation of quisqualate metabotropic receptor potentiates NMDA but not AMPA responses.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Ion Channels; N-Methylaspartate; Neurons; Receptors, AMPA; Receptors, Neurotransmitter | 1991 |
The actions of a conformationally restricted analogue of aspartic acid on mammalian spinal neurones.
Topics: Action Potentials; Animals; Aspartic Acid; Cycloleucine; Kainic Acid; Molecular Conformation; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Spinal Cord; Stereoisomerism | 1991 |
Trans-ACPD-induced Ca2+ signals in cerebellar Purkinje cells.
Topics: Animals; Calcium; Cycloleucine; Dendrites; Electrophysiology; Fluorometry; Osmolar Concentration; Purkinje Cells; Rats; Rats, Inbred Strains; Signal Transduction | 1991 |
In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Choline O-Acetyltransferase; Corpus Striatum; Cycloleucine; Dose-Response Relationship, Drug; Glutamate Decarboxylase; Injections; Ions; Male; Nerve Degeneration; Neurotoxins; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Seizures; Stereoisomerism | 1991 |
Possible heterogeneity of metabotropic glutamate receptors induced in Xenopus oocytes by rat brain mRNA.
Topics: Alanine; Animals; Brain Chemistry; Cycloleucine; GTP-Binding Proteins; Ibotenic Acid; Oocytes; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus | 1991 |
Trans-ACPD (trans-D,L-1-amino-1,3-cyclopentanedicarboxylic acid) elicited oscillation of membrane potentials in rat dorsolateral septal nucleus neurons recorded intracellularly in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cycloleucine; Ibotenic Acid; In Vitro Techniques; Male; Membrane Potentials; Neurons; Neurotoxins; Rats; Rats, Inbred Strains; Sodium | 1991 |
Pharmacological characterization of phosphoinositide-linked glutamate receptor excitation of hippocampal neurons.
Topics: Alanine; Animals; Cycloleucine; Electrophysiology; Hippocampus; In Vitro Techniques; Male; Neurons; Pertussis Toxin; Phorbol Esters; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Virulence Factors, Bordetella | 1990 |
A potent metabotropic glutamate receptor agonist: electrophysiological actions of a conformationally restricted glutamate analogue in the rat spinal cord and Xenopus oocytes.
Topics: Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Brain; Cycloleucine; Electrophysiology; Molecular Conformation; Oocytes; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Spinal Cord; Xenopus | 1990 |
Autoradiographic imaging of phosphoinositide turnover in the brain.
Topics: Alanine; Animals; Autoradiography; Brain; Carbachol; Cerebellum; Cycloleucine; Cytidine; Cytidine Diphosphate Diglycerides; Glutamates; Glutamic Acid; Hippocampus; Neomycin; Phosphatidylinositols; Pirenzepine; Purkinje Cells; Rats; Receptors, Muscarinic; Tissue Distribution | 1990 |
Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Arachidonic Acid; Arachidonic Acids; Aspartic Acid; Cells, Cultured; Corpus Striatum; Cycloleucine; Electrophysiology; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1990 |
The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Ibotenic Acid; Kainic Acid; Magnesium; Membrane Potentials; Neurons; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes.
Topics: Amino Acids; Animals; Cells, Cultured; Corpus Striatum; Cycloleucine; gamma-Aminobutyric Acid; Glutamates; Mice; Oocytes; Phosphatidylinositols; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Xenopus | 1990 |
Potassium conductances in hippocampal neurons blocked by excitatory amino-acid transmitters.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Electric Conductivity; Electrophysiology; Hippocampus; Ibotenic Acid; Kynurenic Acid; Neurons; Potassium Channels; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Muscarinic; Receptors, Neurotransmitter | 1990 |
1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons.
Topics: Alanine; Animals; Calcium; Cerebellum; Cycloleucine; In Vitro Techniques; Neurons; Rats | 1990 |
Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cycloleucine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Excitation of hippocampal neurons by stimulation of glutamate Qp receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Electric Stimulation; Electrophysiology; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Neurons; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Muscarinic; Receptors, Neurotransmitter | 1989 |
Characterization of an extended glutamate receptor of the on bipolar neuron in the vertebrate retina.
Topics: Aminobutyrates; Animals; Cycloleucine; Electrophysiology; Glutamates; Ibotenic Acid; Light; Molecular Conformation; Necturus maculosus; Neurons; Phosphoserine; Photoreceptor Cells; Receptors, Glutamate; Receptors, Neurotransmitter; Retina; Structure-Activity Relationship | 1985 |
Synthesis, resolution, and absolute configuration of the isomers of the neuronal excitant 1-amino-1,3-cyclopentanedicarboxylic acid.
Topics: Amino Acids; Animals; Circular Dichroism; Crystallization; Cycloleucine; Hippocampus; Isomerism; Neurons | 1988 |
Inhibition of proliferative activity by cyclic dipeptides: spirocyclic derivatives of 1-aminocyclopentane-carboxylic acid.
Topics: Amino Acids; Animals; Cell Division; Chick Embryo; Cycloleucine; Dipeptides; Structure-Activity Relationship | 1986 |
A comparative histological and electrophysiological study of some neurotoxins in the rat hippocampus.
Topics: Afferent Pathways; Animals; Cycloleucine; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Inbred Strains; Seizures; Synaptic Transmission | 1982 |
Second-messenger responses in brain slices to elucidate novel glutamate receptors.
Topics: Animals; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Guinea Pigs; Hippocampus; Rats; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Resorcinols; Second Messenger Systems | 1995 |
Developmental change from inhibition to facilitation in the presynaptic control of glutamate exocytosis by metabotropic glutamate receptors.
Topics: Animals; Calcium; Cerebral Cortex; Cycloleucine; Excitatory Amino Acid Agonists; Exocytosis; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Nerve Endings; Neurotoxins; Rats; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Synaptic Membranes; Synaptosomes | 1995 |
(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced burst firing is mediated by a native pertussis toxin-sensitive metabotropic receptor at rat dorsolateral septal nucleus neurons.
Topics: Animals; Basal Ganglia; Cycloleucine; In Vitro Techniques; Male; Membrane Potentials; Neural Pathways; Neurons; Neurotoxins; Patch-Clamp Techniques; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction; Virulence Factors, Bordetella | 1995 |
Receptor subtypes linked to metabotropic glutamate receptor agonist-mediated limbic seizures in mice.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Cycloleucine; Dose-Response Relationship, Drug; Functional Laterality; Limbic System; Male; Mice; Mice, Inbred Strains; Microinjections; Models, Neurological; Neurotoxins; Phosphoserine; Receptors, Metabotropic Glutamate; Seizures; Stereoisomerism | 1995 |
Activation of metabotropic glutamate receptors increase the frequency of spontaneous GABAergic currents through protein kinase A in neonatal rat hippocampal neurons.
Topics: Animals; Animals, Newborn; Cyclic AMP-Dependent Protein Kinases; Cycloleucine; Hippocampus; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission; Time Factors | 1995 |
Metabotropic glutamate receptor agonists reduce paired-pulse depression in the dentate gyrus of the rat in vitro.
Topics: Animals; Cycloleucine; Dentate Gyrus; In Vitro Techniques; Male; Membrane Potentials; Neurotoxins; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synapses | 1995 |
Activation of metabotropic glutamate receptors induces an inward current in rat dopamine mesencephalic neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dopamine; Electrophysiology; Female; Glycine; Male; Neurons; Potassium; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stimulation, Chemical; Tetrodotoxin | 1993 |
Brief calcium transients evoked by glutamate receptor agonists in rat dorsal horn neurons: fast kinetics and mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Female; Glutamates; Glutamic Acid; Ion Channel Gating; Kainic Acid; Kinetics; Lanthanum; N-Methylaspartate; Neurons; Neurotoxins; Photometry; Potassium; Pregnancy; Presynaptic Terminals; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1993 |
Induction of cerebellar long-term depression in culture requires postsynaptic action of sodium ions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Cycloleucine; Electrophysiology; Embryo, Mammalian; Evoked Potentials; Mice; N-Methylaspartate; Neuronal Plasticity; Neurons; Neurotoxins; Picrotoxin; Quisqualic Acid; Receptors, AMPA; Sodium; Synapses; Tetrodotoxin; Veratridine | 1993 |
Membrane currents evoked by excitatory amino acid agonists in ON bipolar cells of the mudpuppy retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Animals; Cadmium; Cell Membrane; Cobalt; Cycloleucine; Electrophysiology; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Necturus maculosus; Neurotransmitter Agents; Receptors, Amino Acid; Retina | 1993 |
Ionotropic and metabotropic components of electrophysiological response of cerebellar Purkinje neurons to excitatory amino acids.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Electrophysiology; Neurotoxins; Purkinje Cells; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate | 1993 |
Glutamate-evoked release of arachidonic acid from mouse brain astrocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Astrocytes; Brain; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Cycloleucine; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Neurotoxins; Organ Specificity; Quisqualic Acid; Receptors, Glutamate; Time Factors; Tritium | 1994 |
Metabotropic and ionotropic excitatory amino acid receptor agonists induce different behavioral effects in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ibotenic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Seizures | 1993 |
Metabotropic excitatory amino acid receptor agonists selectively potentiate behavioral effects induced by ionotropic excitatory amino acid receptor agonists in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; Drug Synergism; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Neurotoxins; Pentylenetetrazole; Receptors, Glutamate; Seizures | 1993 |
Metabotropic glutamate receptor modulation of cAMP accumulation in the neonatal rat hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Deaminase; Animals; Animals, Newborn; Colforsin; Cyclic AMP; Cycloleucine; Female; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Neurotoxins; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1993 |
The actions of phenylglycine derived metabotropic glutamate receptor antagonists on multiple (1S,3R)-ACPD responses in the rat nucleus of the tractus solitarius.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Stem; Cycloleucine; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Membrane Potentials; Muscimol; Neurons; Neurotoxins; Rats; Receptors, GABA-A; Solitary Nucleus; Structure-Activity Relationship; Synaptic Transmission | 1993 |
Inhibition of phosphoprotein phosphatases blocks metabotropic glutamate receptor effects in the rat nucleus tractus solitarii.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Ethers, Cyclic; In Vitro Techniques; Marine Toxins; Membrane Potentials; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Receptors, Metabotropic Glutamate; Solitary Nucleus; Tacrolimus | 1994 |
Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acids, Dicarboxylic; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cycloleucine; Cyclopropanes; Glycine; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Phosphatidylinositols; Receptors, Metabotropic Glutamate | 1994 |
Activation of metabotropic glutamate receptors differentially affects two classes of hippocampal interneurons and potentiates excitatory synaptic transmission.
Topics: Animals; Calcium; Cycloleucine; Electricity; Electrophysiology; Hippocampus; Interneurons; Intracellular Membranes; Ion Channels; Neurotoxins; Nucleotides, Cyclic; Oscillometry; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1994 |
Penile erection and yawning induced by paraventricular NMDA injection in male rats are mediated by oxytocin.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dopamine; Injections; Injections, Intraventricular; Male; N-Methylaspartate; Neurotoxins; Oxytocin; Paraventricular Hypothalamic Nucleus; Penile Erection; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Synaptic Transmission; Yawning | 1994 |
The effect of experimental ischaemia and excitatory amino acid agonists on the GABA and serotonin immunoreactivities in the rabbit retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cycloleucine; Dextromethorphan; Eye Proteins; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamic Acid; Intraocular Pressure; Ischemia; Kainic Acid; Kynurenic Acid; Memantine; N-Methylaspartate; Oxygen; Potassium Cyanide; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Vessels; Serotonin | 1994 |
Glutamate receptor-driven activation of transcription factors in primary neuronal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Astrocytes; Base Sequence; Binding Sites; Cell Nucleus; Cell Survival; Cells, Cultured; Cycloleucine; Embryo, Mammalian; Gene Expression; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Mice; Molecular Sequence Data; N-Methylaspartate; Neurons; Proto-Oncogene Proteins; Proto-Oncogenes; Quisqualic Acid; Rats; Receptors, Glutamate; Transcription Factors | 1994 |
Competitive antagonism by phenylglycine derivatives at type I metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Benzoates; Binding, Competitive; Calcium; Cells, Cultured; CHO Cells; Cricetinae; Cycloleucine; Cytidine Diphosphate Diglycerides; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Kainic Acid; Neurons; Neurotoxins; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Quisqualic Acid; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Signal Transduction | 1994 |
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine Maleate; Glioma; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Ion Channels; Kainic Acid; Kinetics; Magnesium Chloride; N-Methylaspartate; Neurotoxins; Pyrrolidinones; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Signal Transduction; Tumor Cells, Cultured | 1994 |
Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons.
Topics: Acute Disease; Afferent Pathways; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arthritis; Cycloleucine; Inflammation; Knee Joint; Male; N-Methylaspartate; Neurons; Pain; Pressure; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1994 |
Inhibition of endogenous dopamine release in amphibian retina by L-2-amino-4-phosphonobutyric acid (L-AP4) and trans-2-aminocyclopentane-1,3-dicarboxylate (ACPD).
Topics: Aminobutyrates; Animals; Cycloleucine; Dopamine; Ion Channels; Light; Neurotoxins; Picrotoxin; Receptors, Metabotropic Glutamate; Retina; Retinal Cone Photoreceptor Cells; Retinal Rod Photoreceptor Cells; Stereoisomerism; Xenopus laevis | 1994 |
Spinal mediators of hyperalgesia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Arginine; Calcium; Cycloleucine; Disease Models, Animal; Excitatory Amino Acids; Hot Temperature; Hyperalgesia; Male; N-Methylaspartate; Neuronal Plasticity; Neurons, Afferent; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stress, Mechanical | 1994 |
Role of metabotropic glutamate receptors in ventrolateral medulla of hypertensive rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Cycloleucine; Heart Rate; Hypertension; Male; Medulla Oblongata; N-Methylaspartate; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Metabotropic Glutamate; Sympathetic Nervous System | 1994 |
Regulation of nitric oxide synthase activity in cortical slices by excitatory amino acids and calcium.
Topics: Amino Acid Oxidoreductases; Amino Acids; Animals; Arginine; Calcium; Cerebral Cortex; Citrulline; Cycloleucine; In Vitro Techniques; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1994 |
Potentiation of synaptic transmission in the rat hippocampal slice by exogenous L-glutamate and selective L-glutamate receptor subtype agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Evoked Potentials; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hippocampus; In Vitro Techniques; Iontophoresis; N-Methylaspartate; Nerve Fibers; Neurotoxins; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Synapses; Synaptic Transmission | 1994 |
Protein kinase C modulates calcium sensitivity of nitric oxide synthase in cerebellar slices.
Topics: Amino Acid Oxidoreductases; Animals; Calcium; Cerebellum; Cyclic GMP; Cycloleucine; Enzyme Activation; Excitatory Amino Acid Agonists; Guanylate Cyclase; In Vitro Techniques; Male; Naphthalenes; Nitric Oxide Synthase; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Wistar; Receptors, Glutamate; Signal Transduction; Tetradecanoylphorbol Acetate | 1995 |
Ammonium acetate inhibits ionotropic receptors and differentially affects metabotropic receptors for glutamate.
Topics: 1-Methyl-3-isobutylxanthine; Acetates; Colforsin; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Neurotoxins; Phosphatidylinositols; Receptors, AMPA; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1994 |
Modulation of neuropeptide FF release from rat spinal cord slices by glutamate. Involvement of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dizocilpine Maleate; Glutamic Acid; In Vitro Techniques; Iodine Radioisotopes; Male; Membranes; N-Methylaspartate; Neuropeptides; Neurotoxins; Oligopeptides; Radioimmunoassay; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1994 |
Glutamate-induced swelling of single astroglial cells in primary culture.
Topics: Aminobutyrates; Animals; Animals, Newborn; Astrocytes; Calcium; Cell Size; Cells, Cultured; Cerebral Cortex; Cycloleucine; Extracellular Space; Glutamic Acid; GTP-Binding Proteins; Ion Channels; Neurotoxins; Pertussis Toxin; Potassium Channels; Rats; Receptors, Glutamate; Spectrometry, Fluorescence; Virulence Factors, Bordetella | 1994 |
A glutamate-activated chloride current in cone-driven ON bipolar cells of the white perch retina.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chloride Channels; Chlorides; Cycloleucine; Dendrites; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurotoxins; Patch-Clamp Techniques; Perches; Picrotoxin; Quinoxalines; Quisqualic Acid; Receptors, Metabotropic Glutamate; Retina; Retinal Cone Photoreceptor Cells; Strychnine | 1995 |
AMPA receptor activation regulates the glutamate metabotropic receptor stimulated phosphatidylinositol turnover in human cerebral cortex slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcimycin; Cerebral Cortex; Child; Cycloleucine; Dizocilpine Maleate; Female; Glutamic Acid; Humans; Male; Middle Aged; N-Methylaspartate; Phosphatidylinositols; Quisqualic Acid; Receptors, AMPA; Receptors, Metabotropic Glutamate; Signal Transduction; Tetrodotoxin | 1995 |
GFAP-positive hippocampal astrocytes in situ respond to glutamatergic neuroligands with increases in [Ca2+]i.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Rats | 1995 |
Intracellular acidification and Ca2+ transients in cultured rat cerebellar astrocytes evoked by glutamate agonists and noradrenaline.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Calcium; Cells, Cultured; Cerebellum; Cycloleucine; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Fura-2; Glutamic Acid; Hydrogen-Ion Concentration; Kainic Acid; Neurotoxins; Norepinephrine; Rats; Receptors, Metabotropic Glutamate | 1995 |
Increased perinuclear Ca2+ activity evoked by metabotropic glutamate receptor activation in rat hippocampal neurones.
Topics: Animals; Calcium; Cell Nucleus; Cells, Cultured; Cycloleucine; Cytoplasm; Excitatory Amino Acid Agonists; Fluorescent Dyes; Fura-2; Hippocampus; Hydrogen-Ion Concentration; Microscopy, Confocal; Neurons; Neurotoxins; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1995 |
Presynaptic metabotropic glutamatergic regulation of inhibitory synapses in rat cerebellar slices.
Topics: Action Potentials; Animals; Cerebellar Cortex; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Interneurons; Purkinje Cells; Rats; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Synapses; Synaptic Transmission | 1995 |
Binding of the new radioligand (S)-[3H]AMPA to rat brain synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardiine.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cycloleucine; Male; Pyrimidinones; Quinoxalines; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Stereoisomerism; Synaptic Membranes; Tritium; Uracil | 1995 |
Potentiation of excitatory postsynaptic potentials by a metabotropic glutamate receptor agonist (1S,3R-ACPD) in frog spinal motoneurons.
Topics: Animals; Cycloleucine; Electric Stimulation; Feedback; In Vitro Techniques; Magnesium; Membrane Potentials; Motor Neurons; Neurotoxins; Rana catesbeiana; Receptors, Metabotropic Glutamate; Spinal Cord | 1995 |
Presynaptic depression of inhibitory postsynaptic potentials by metabotropic glutamate receptors in rat hippocampal CA1 pyramidal cells.
Topics: Animals; Cycloleucine; gamma-Aminobutyric Acid; Hippocampus; Male; Membrane Potentials; Neurotoxins; Presynaptic Terminals; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Time Factors | 1995 |
Modulation by ionotropic excitatory amino acids and potassium of (+/-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid-stimulated phosphoinositide hydrolysis in mouse cerebellar granule cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Survival; Cerebellum; Cycloleucine; Drug Synergism; Excitatory Amino Acids; Hydrolysis; Magnesium; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Phosphatidylinositols; Potassium; Receptors, Amino Acid; Receptors, Metabotropic Glutamate | 1995 |
Reversible and irreversible neuronal injury induced by intrahippocampal infusion of the mGluR agonist 1S,3R-ACPD in the rat.
Topics: Animals; Cycloleucine; Hippocampus; Infusions, Parenteral; Male; Microscopy, Electron; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Time Factors | 1995 |
Activation of K+ channels by stimulation of metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cycloleucine; Glutamic Acid; Hippocampus; In Vitro Techniques; Neurons; Potassium Channels; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stimulation, Chemical; Valine | 1995 |
The effect of lorazepam tolerance and withdrawal on metabotropic glutamate receptor function.
Topics: Animals; Cerebral Cortex; Cyclic AMP; Cycloleucine; Drug Tolerance; Hydrolysis; In Vitro Techniques; Lorazepam; Male; Mice; Phosphatidylinositols; Protein Kinases; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Seizures; Substance Withdrawal Syndrome | 1995 |
Transient coupling of NMDA receptor with ip3 production in cultured cells of the avian retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Chick Embryo; Cycloleucine; Dizocilpine Maleate; gamma-Aminobutyric Acid; Inositol 1,4,5-Trisphosphate; Kainic Acid; N-Methylaspartate; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Retina; Time Factors | 1995 |
Metabotropic glutamate receptor agonists inhibit endogenous glutamate release from rat striatal synaptosomes.
Topics: 4-Aminopyridine; Aminobutyrates; Animals; Corpus Striatum; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Rats; Receptors, Metabotropic Glutamate; Synaptosomes | 1995 |
Intrastriatal and intrasubthalamic stimulation of metabotropic glutamate receptors: a behavioral and Fos immunohistochemical study.
Topics: Animals; Basal Ganglia; Behavior, Animal; Cycloleucine; Immunohistochemistry; Injections; Male; Neostriatum; Neurotoxins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Rotation; Stereotyped Behavior; Thalamus | 1995 |
Persistent current oscillations produced by activation of metabotropic glutamate receptors in immature rat CA3 hippocampal neurons.
Topics: Animals; Animals, Newborn; Caffeine; Calcium; Cycloleucine; Electrophysiology; Hippocampus; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Neurons; Neurotoxins; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Ryanodine; Sodium Channels; Tetrodotoxin | 1995 |
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.
Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line; Chelating Agents; Cycloleucine; Embryo, Mammalian; Fetus; Glioma; Glutamic Acid; Hippocampus; Humans; Indoles; Kidney; Kinetics; Maleimides; N-Methylaspartate; Neuroblastoma; Neurons; Neurotoxins; PC12 Cells; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Protein Kinase C; Protein Processing, Post-Translational; Pyrimidines; Quinacrine; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1995 |
The function of metabotropic excitatory amino acid receptors in synaptic transmission in the thalamus: studies with novel phenylglycine antagonists.
Topics: Action Potentials; Air; Animals; Benzoates; Cycloleucine; Glycine; Hot Temperature; Iontophoresis; Neurons; Nociceptors; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Thalamus | 1994 |
Differential modulation of carbachol and trans-ACPD-stimulated phosphoinositide turnover following traumatic brain injury.
Topics: Animals; Brain Injuries; Carbachol; Cycloleucine; Male; Neurotoxins; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1995 |
Dual modulation of synaptic inhibition by distinct metabotropic glutamate receptors in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Cycloleucine; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Neurotoxins; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission; Tetrodotoxin | 1995 |
Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes.
Topics: Animals; Astrocytes; Cerebral Cortex; Cycloleucine; Growth Substances; Hydrolysis; Neurotoxins; Pertussis Toxin; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Up-Regulation; Virulence Factors, Bordetella | 1995 |
Protein kinase C differently regulates quisqualate- and 1S,3R-trans aminocyclopentane dicarboxylate-induced phosphoinositide hydrolysis during in vitro development of hippocampal neurons.
Topics: Alkaloids; Animals; Carbachol; Cells, Cultured; Cycloleucine; Enzyme Activation; Hippocampus; Hydrolysis; Neurons; Neurotoxins; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Protein Kinase C; Quisqualic Acid; Rats; Staurosporine | 1995 |
Synergistic activation of phosphoinositide hydrolysis induced in brain slices by norepinephrine and the excitatory amino acid agonist, trans-ACPD.
Topics: Animals; Biotransformation; Brain Chemistry; Cycloleucine; Drug Synergism; Hippocampus; Hydrolysis; In Vitro Techniques; Inositol; Male; Norepinephrine; Phosphatidylinositols; Propranolol; Rats; Rats, Sprague-Dawley; Ruthenium Red; Verapamil | 1993 |
Actions of agonists of metabotropic glutamate receptors on synaptic transmission and transmitter release in the olfactory cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cycloleucine; Ibotenic Acid; In Vitro Techniques; Male; Mice; Neurotransmitter Agents; Olfactory Bulb; Potassium; Quinoxalines; Receptors, Glutamate; Synapses; Synaptic Transmission | 1993 |
Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cerebral Cortex; Cycloleucine; Glycine; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Phosphatidylinositols; Rats; Receptors, Glutamate; Spinal Cord; Thalamus | 1993 |
Potentiation of NMDA receptor-mediated transmission in turtle cerebellar granule cells by activation of metabotropic glutamate receptors.
Topics: 2-Amino-5-phosphonovalerate; Adenylate Cyclase Toxin; Animals; Cerebellum; Colforsin; Cycloleucine; Evoked Potentials; In Vitro Techniques; Isomerism; Naphthalenes; Nitric Oxide; Pertussis Toxin; Polycyclic Compounds; Purkinje Cells; Quisqualic Acid; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Tetradecanoylphorbol Acetate; Turtles; Virulence Factors, Bordetella | 1993 |
Activation of metabotropic glutamate receptors produces reciprocal regulation of ionotropic glutamate and GABA responses in the nucleus of the tractus solitarius of the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Electrophysiology; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Ibotenic Acid; Male; Medulla Oblongata; Muscimol; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synapses | 1993 |
(R,S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors mediate a calcium-dependent inhibition of the metabotropic glutamate receptor-stimulated formation of inositol 1,4,5-trisphosphate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol 1,4,5-Trisphosphate; N-Methylaspartate; Protein Kinases; Rats; Receptors, AMPA; Receptors, Glutamate | 1993 |
Quisqualate resolves two distinct metabotropic [3H]glutamate binding sites.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Corpus Striatum; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid | 1993 |
Activation of metabotropic glutamate receptors induces an outward current which is potentiated by methylxanthines in rat cerebellar Purkinje cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cycloleucine; Electrophysiology; Fluorometry; Fura-2; In Vitro Techniques; Ion Channels; Male; Purkinje Cells; Rats; Receptors, Glutamate; Xanthines | 1993 |
Stimulation by glutamate receptors of arachidonic acid release depends on the Na+/Ca2+ exchanger in neuronal cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Calcium; Carrier Proteins; Cells, Cultured; Corpus Striatum; Cycloleucine; Electrophysiology; Ibotenic Acid; Mice; N-Methylaspartate; Neurons; Phospholipases A; Phospholipases A2; Protein Kinase C; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sodium; Sodium-Calcium Exchanger; Veratridine; Virulence Factors, Bordetella | 1993 |
(2s,1'R,2'R,3'R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbachol; Cycloleucine; Cyclopropanes; Glycine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1993 |
N-acetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cerebellum; Colforsin; Cyclic AMP; Cycloleucine; Dipeptides; Glutamates; Glutamic Acid; Granulocytes; Inositol Phosphates; Receptors, Glutamate | 1993 |
Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzoates; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; Ibotenic Acid; Motor Neurons; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Neurotoxins; Rats; Spinal Cord; Stereoisomerism; Thalamus | 1993 |
Excitatory amino acid-induced slow biphasic responses of free intracellular calcium in human neuroblastoma cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcium; Cycloleucine; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Tumor Cells, Cultured | 1993 |
Acute mechanical hyperalgesia is produced by coactivation of AMPA and metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Hot Temperature; Ibotenic Acid; Male; N-Methylaspartate; Neurotoxins; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Quinoxalines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Spinal Cord | 1993 |
Toward an understanding of the role of glutamate in experimental parkinsonism: agonist-sensitive sites in the basal ganglia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Ganglia; Cycloleucine; Electromyography; Glutamates; Glutamic Acid; Kainic Acid; Male; Muscles; N-Methylaspartate; Parkinson Disease; Rats; Receptors, Glutamate | 1993 |
Effects of bromohomoibotenate on metabotropic glutamate receptors.
Topics: Aminobutyrates; Animals; Binding, Competitive; Cell Line; Cerebral Cortex; Cricetinae; Cyclic AMP; Cycloleucine; Dose-Response Relationship, Drug; Glutamic Acid; Hippocampus; Hydrolysis; Ibotenic Acid; Kidney; Membranes; Phosphatidylinositols; Quinoxalines; Receptors, AMPA; Receptors, Metabotropic Glutamate; Stereoisomerism | 1994 |
Metabolic, hormonal, and hemodynamic changes induced by metabotropic excitatory amino acid agonist (1S,3R)-ACPD.
Topics: Animals; Blood Circulation; Cycloleucine; Glucose; Hemodynamics; Hormones; Male; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Stress, Physiological | 1995 |
Modulation of GABAC receptors in rat retinal bipolar cells by protein kinase C.
Topics: Animals; Baclofen; Bicuculline; Cell Polarity; Cycloleucine; Down-Regulation; Electrophysiology; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Receptors, GABA; Receptors, Serotonin; Retina | 1994 |
Metabotropic glutamate receptors negatively coupled to adenylate cyclase inhibit N-methyl-D-aspartate receptor activity and prevent neurotoxicity in mesencephalic neurons in vitro.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acids, Dicarboxylic; Animals; Cells, Cultured; Cyclic GMP; Cycloleucine; GTP-Binding Proteins; In Vitro Techniques; Mesencephalon; Mice; N-Methylaspartate; Neurons; Neurotoxins; Phosphatidylinositols; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems | 1995 |
Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide.
Topics: Aminobutyrates; Amyloid beta-Peptides; Animals; Apoptosis; Benzoates; Calcium Channels; Cells, Cultured; Cerebellum; Cycloleucine; Glycine; Mice; Nerve Degeneration; Neurons; Peptide Fragments; Phosphoserine; Receptors, Metabotropic Glutamate | 1995 |
Electrical stimulation of the prefrontal cortex increases dopamine release in the nucleus accumbens of the rat: modulation by metabotropic glutamate receptors.
Topics: Animals; Cycloleucine; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Kinetics; Kynurenic Acid; Male; Microdialysis; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Tetrodotoxin; Time Factors | 1995 |
Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Line; Cyclic AMP; Cycloleucine; DNA Primers; Female; Gene Library; Genetic Variation; Glutamic Acid; Ibotenic Acid; In Situ Hybridization; Kidney; Molecular Sequence Data; Neurotoxins; Oocytes; Polymerase Chain Reaction; Prosencephalon; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Restriction Mapping; RNA, Messenger; Spleen; Swine; Transfection; Xenopus | 1995 |
Modulation of NMDA effects on agonist-stimulated phosphoinositide turnover by memantine in neonatal rat cerebral cortex.
Topics: Animals; Animals, Newborn; Carbachol; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Drug Interactions; Female; Inositol 1,4,5-Trisphosphate; Male; Memantine; N-Methylaspartate; Neurotoxins; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Polyphosphates; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1995 |
Regulation of retinal glial cell proliferation by antiproliferative molecules.
Topics: Alkaloids; Benzophenanthridines; Cell Division; Cells, Cultured; Cycloleucine; Epidermal Growth Factor; Fibroblast Growth Factor 2; Humans; Insulin-Like Growth Factor I; Neuroglia; Phenanthridines; Platelet-Derived Growth Factor; Protein Kinase C; Retina; Transforming Growth Factor beta | 1995 |
Activation of a nonselective cationic conductance by metabotropic glutamatergic and muscarinic agonists in CA3 pyramidal neurons of the rat hippocampus.
Topics: Animals; Barium; Cadmium; Cations, Divalent; Cesium; Cholinergic Agents; Cycloleucine; Egtazic Acid; GTP-Binding Proteins; Hippocampus; Magnesium; Membrane Potentials; Neurotoxins; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Second Messenger Systems; Stereoisomerism | 1995 |
Activation of metabotropic glutamate receptors prevents neuronal apoptosis in culture.
Topics: Animals; Apoptosis; Cells, Cultured; Cycloleucine; Dose-Response Relationship, Drug; Glutamates; Microscopy, Fluorescence; Neurons; Potassium; Rats; Receptors, Glutamate | 1995 |
I.c.v. infusions of ACPD(1S,3R) attenuate learning in a Morris water maze paradigm.
Topics: Analysis of Variance; Animals; Cerebral Ventricles; Cycloleucine; Factor Analysis, Statistical; Infusions, Parenteral; Male; Maze Learning; Neurotoxins; Rats; Rats, Wistar; Time Factors | 1994 |
Activation of a metabotropic glutamate receptor increases intracellular calcium concentrations in neurons of the avian cochlear nucleus.
Topics: Animals; Calcium; Chick Embryo; Cochlear Nucleus; Cycloleucine; Glutamic Acid; In Vitro Techniques; Intracellular Membranes; Neurons; Osmolar Concentration; Quisqualic Acid; Receptors, Metabotropic Glutamate | 1995 |
Pharmacologically distinct, pertussis toxin-resistant inward currents evoked by metabotropic glutamate receptor (mGluR) agonists in dorsolateral septal nucleus (DLSN) neurons.
Topics: Animals; Cycloleucine; Electric Conductivity; Male; Neurons; Neurotoxins; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Septum Pellucidum; Virulence Factors, Bordetella | 1995 |
Effects of metabotropic glutamate receptor activation on the cellular and network level in the lamprey spinal cord.
Topics: Animals; Cadmium; Cycloleucine; In Vitro Techniques; Lampreys; Locomotion; Nerve Net; Neurons; Neurotoxins; Receptors, Metabotropic Glutamate; Spinal Cord; Swimming; Synapses; Tetrodotoxin | 1994 |
Induction of LTD but not LTP through metabotropic glutamate receptors in visual cortex.
Topics: Animals; Benzoates; Calcium; Cycloleucine; Depression, Chemical; Glycine; In Vitro Techniques; Long-Term Potentiation; Neuronal Plasticity; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Visual Cortex | 1994 |
Metabotropic glutamate receptor (mGluR)-mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR.
Topics: Animals; Brain; Calcium; Calcium-Transporting ATPases; Cyclic AMP; Cycloleucine; Glycine; Hydrolysis; In Vitro Techniques; Intracellular Membranes; Neurotoxins; Phosphatidylinositols; Protein Kinase C; Rats; Receptors, Metabotropic Glutamate; Resorcinols; Terpenes; Thapsigargin | 1995 |
Changes of pharmacological properties of (1S,3R)-ACPD-sensitive glutamate binding sites in developing mouse cerebellum.
Topics: Aminobutyrates; Animals; Autoradiography; Cerebellum; Cycloleucine; Kinetics; Mice; Receptors, Metabotropic Glutamate | 1994 |
Pharmacological dissociation of glutamatergic metabotropic signal transduction pathways in cortical astrocytes.
Topics: Animals; Astrocytes; Benzoates; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cycloleucine; Dicarboxylic Acids; Glutamic Acid; Glycine; Isoproterenol; Neuroglia; Neurotoxins; Phosphatidylinositols; Pyrrolidines; Rats; Receptors, Metabotropic Glutamate; Signal Transduction | 1994 |
A study of the synergism between metabotropic glutamate receptor activation and arachidonic acid in the rat hippocampus.
Topics: Animals; Arachidonic Acid; Cyclic AMP; Cycloleucine; Drug Synergism; Glutamic Acid; Hippocampus; Male; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptosomes | 1994 |
Long-term depression requiring tACPD-receptor activation and NMDA-receptor blockade.
Topics: Animals; Cycloleucine; In Vitro Techniques; Neurotoxins; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tetany; Valine; Visual Cortex | 1994 |
Tetanically induced LTP involves a similar increase in the AMPA and NMDA receptor components of the excitatory postsynaptic current: investigations of the involvement of mGlu receptors.
Topics: Animals; Cycloleucine; Electric Stimulation; Hippocampus; Long-Term Potentiation; Rats; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1995 |
Increased production of inositol phosphates and diacylglycerol in aged cognitively impaired rats after stimulation of muscarinic, metabotropic-glutamate and endothelin receptors.
Topics: Aging; Animals; Behavior, Animal; Carbachol; Cognition Disorders; Cycloleucine; Diglycerides; Inositol Phosphates; Male; Maze Learning; Rats; Receptors, Endothelin; Receptors, Glutamate; Receptors, Muscarinic; Signal Transduction | 1995 |
Metabotropic glutamate receptor-induced disinhibition is mediated by reduced transmission at excitatory synapses onto interneurons and inhibitory synapses onto pyramidal cells.
Topics: Animals; Cycloleucine; Electric Stimulation; Interneurons; Male; Neural Inhibition; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission | 1994 |
Metabotropic glutamate receptors mediate a post-tetanic excitation of guinea-pig hippocampal inhibitory neurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Cycloleucine; Electric Stimulation; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Neurons, Afferent; Picrotoxin; Potassium Chloride; Pyramidal Cells; Quinoxalines; Receptors, Metabotropic Glutamate; Synapses | 1993 |
Glutamate receptors on type I vestibular hair cells of guinea-pig.
Topics: Animals; Calcium; Cell Separation; Cycloleucine; Glutamates; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory; Intracellular Membranes; Receptors, AMPA; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1993 |
Inhibition of a slow synaptic response by a metabotropic glutamate receptor antagonist in hippocampal CA3 pyramidal cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Bicuculline; Cycloleucine; Evoked Potentials; Glycine; Hippocampus; In Vitro Techniques; Nerve Fibers; Neurotoxins; Pyramidal Cells; Quinoxalines; Rats; Receptors, Glutamate; Synapses | 1993 |
Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation.
Topics: Animals; Cycloleucine; Hippocampus; In Vitro Techniques; Neurotransmitter Agents; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Time Factors | 1994 |
Potentiating and depressant effects of metabotropic glutamate receptor agonists on high-voltage-activated calcium currents in cultured retinal ganglion neurons from postnatal mice.
Topics: Alanine; Aminobutyrates; Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Glutamates; Glutamic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Intracellular Fluid; Mice; omega-Conotoxin GVIA; Organophosphorus Compounds; Peptides; Quisqualic Acid; Receptors, Metabotropic Glutamate; Retinal Ganglion Cells | 1994 |
(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid attenuates N-methyl-D-aspartate-induced neuronal cell death in cortical cultures via a reduction in delayed Ca2+ accumulation.
Topics: Animals; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Cycloleucine; Fetus; Glutamates; Glutamic Acid; Kinetics; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neurotoxins; Pertussis Toxin; Phosphatidylinositols; Rats; Time Factors; Virulence Factors, Bordetella | 1993 |
An ibotenate-selective metabotropic glutamate receptor mediates protein phosphorylation in cultured hippocampal pyramidal neurons.
Topics: Animals; Calcium; Cycloleucine; Diglycerides; Embryo, Mammalian; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol; Inositol Phosphates; Kainic Acid; Myristic Acid; Myristic Acids; N-Methylaspartate; Nerve Tissue Proteins; Neurotoxins; Pertussis Toxin; Phosphatidylcholines; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Protein Kinase C; Pyramidal Cells; Quisqualic Acid; Rats; Receptors, Glutamate; Stearic Acids; Virulence Factors, Bordetella | 1994 |
Activation of glutamate receptors stimulates the formation of nitrite in synaptosomes from rat cerebellum.
Topics: Animals; Cerebellum; Cycloleucine; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Nitrites; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synaptosomes | 1994 |
Glutamate modulates [Ca2+]i and gonadotropin-releasing hormone secretion in immortalized hypothalamic GT1-7 neurons.
Topics: Animals; Calcium; Cells, Cultured; Cycloleucine; Excitatory Amino Acid Antagonists; Fura-2; Glutamates; Glutamic Acid; Gonadotropin-Releasing Hormone; Hypothalamus; Inositol Phosphates; Mice; Mice, Transgenic; Neurons; Neurotoxins; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence | 1994 |
Metabotropic glutamate response in acutely dissociated hippocampal CA1 pyramidal neurones of the rat.
Topics: Animals; Calcium; Cycloleucine; Dose-Response Relationship, Drug; Electrophysiology; Glutamates; Glutamic Acid; GTP-Binding Proteins; Hippocampus; Intracellular Membranes; Osmolar Concentration; Potassium Channels; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1994 |
Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S,3R-ACPD in neonatal rat cerebral cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Calcium; Cerebral Cortex; Cycloleucine; Dizocilpine Maleate; Female; Hydrolysis; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; N-Methylaspartate; Neurotoxins; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1994 |
Distribution and ontogeny of 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid-sensitive and quisqualate-insensitive [3H]glutamate binding sites in the rat brain.
Topics: Animals; Anions; Brain; Bromides; Calcium; Cell Membrane; Chlorides; Cycloleucine; Female; Glutamates; Glutamic Acid; Hypothalamus; Male; Prosencephalon; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tritium | 1994 |
Metabotropic glutamate receptor activation induces astroglial swelling.
Topics: Animals; Animals, Newborn; Astrocytes; Calcium; Cell Size; Cells, Cultured; Cerebral Cortex; Cycloleucine; Glutamates; Glutamic Acid; Ibotenic Acid; Rats; Receptors, Metabotropic Glutamate | 1994 |
Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Animals, Newborn; Cycloleucine; Excitatory Amino Acids; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Neurons, Afferent; Neurotoxins; Rats; Receptors, Metabotropic Glutamate; Spinal Cord; Synapses | 1994 |
A subpopulation of cerebellar granule neurons in culture expresses a functional mGluR1 metabotropic glutamate receptor: effect of depolarizing growing conditions.
Topics: Animals; Calcium; Cell Division; Cells, Cultured; Cerebellum; Cycloleucine; Intracellular Fluid; Membrane Potentials; Neurons; Pertussis Toxin; Potassium Chloride; Rats; Receptors, Metabotropic Glutamate; Virulence Factors, Bordetella | 1993 |
Actions of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) in retinal ON bipolar cells indicate that it is an agonist at L-AP4 receptors.
Topics: Aminobutyrates; Animals; Cycloleucine; Excitatory Amino Acid Agonists; GABA-A Receptor Agonists; Glycine; Necturus maculosus; Receptors, GABA-A; Receptors, Glutamate; Retina | 1994 |
The effects of L-glutamate and trans-(+-)-1-amino-1,3-cyclopentanedicarboxylate on phosphoinositide hydrolysis can be pharmacologically differentiated.
Topics: Alanine; Animals; Animals, Newborn; Aspartic Acid; Benzoates; Brain; Cerebellum; Cycloleucine; Glutamic Acid; Glycine; Hippocampus; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kinetics; Neurotoxins; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Stereoisomerism | 1994 |
Glutamate exocytosis and MARCKS phosphorylation are enhanced by a metabotropic glutamate receptor coupled to a protein kinase C synergistically activated by diacylglycerol and arachidonic acid.
Topics: Animals; Arachidonic Acid; Calcium; Cerebral Cortex; Cycloleucine; Cytosol; Diglycerides; Drug Synergism; Enzyme Activation; Exocytosis; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Neurotoxins; Phosphorylation; Protein Kinase C; Proteins; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptosomes | 1994 |
Pharmacological similarity between the retinal APB receptor and the family of metabotropic glutamate receptors.
Topics: Ambystoma; Aminobutyrates; Animals; Culture Techniques; Cycloleucine; Necturus; Neurotoxins; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Retina; Synaptic Transmission | 1994 |
Visualization of agonist-stimulated inositol phospholipid turnover in individual neurons of the rat cerebral cortex and hippocampus.
Topics: Animals; Autoradiography; Carbachol; Cerebral Cortex; Cycloleucine; Cytidine Monophosphate; Female; Glycerophospholipids; Hippocampus; In Vitro Techniques; Inositol; Lithium; Neurons; Phosphatidic Acids; Phosphatidylinositols; Rats; Rats, Wistar; Stimulation, Chemical | 1994 |
MCPG antagonizes metabotropic glutamate receptors but not long-term potentiation in the hippocampus.
Topics: Animals; Benzoates; Cycloleucine; Glycine; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Neurotoxins; Receptors, Metabotropic Glutamate; Stereoisomerism; Synapses; Synaptic Transmission | 1994 |
Agonists for metabotropic glutamate receptors in the rat delay recovery from halothane anesthesia.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Anesthesia; Animals; Cycloleucine; Cyclopropanes; Glycine; Halothane; Injections, Intraventricular; Male; Neurotoxins; Postural Balance; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1994 |
Stereoselective antagonism of the metabotropic glutamate receptor mGluR1 alpha by alpha-methyl-4-carboxyphenylglycine.
Topics: Animals; Benzoates; Calcium; CHO Cells; Cricetinae; Cycloleucine; Glycine; Perfusion; Receptors, Metabotropic Glutamate; Stereoisomerism | 1994 |
L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a.
Topics: Alanine Transaminase; Animals; Asparagine; Aspartic Acid; Cell Line; Cell Membrane; Cricetinae; Cycloleucine; Cysteine; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Glutamate Decarboxylase; Glutamic Acid; Hydrolysis; Kidney; N-Methylaspartate; Phosphatidylinositols; Pyrrolidines; Receptors, Metabotropic Glutamate | 1994 |
Chronic activation of muscarinic and metabotropic glutamate receptors down-regulates type I inositol 1,4,5-trisphosphate receptor expression in cerebellar granule cells.
Topics: Animals; Calcium; Calcium Channels; Carbachol; Cells, Cultured; Cerebellum; Cycloleucine; Down-Regulation; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Kinetics; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; RNA, Messenger | 1994 |
Activation of metabotropic glutamate receptors inhibits calcium currents and GABA-mediated synaptic potentials in striatal neurons.
Topics: Alanine; Animals; Calcium; Corpus Striatum; Cycloleucine; Electrophysiology; gamma-Aminobutyric Acid; Male; Neurons; Neurotoxins; omega-Conotoxin GVIA; Peptides; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1994 |
The glutamate uptake inhibitor L-trans-pyrrolidine-2,4-dicarboxylate depresses excitatory synaptic transmission via a presynaptic mechanism in cultured hippocampal neurons.
Topics: Animals; Benzoates; Cells, Cultured; Cycloleucine; Dicarboxylic Acids; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Neurons; Presynaptic Terminals; Pyrrolidines; Rats; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Synaptic Transmission | 1994 |
The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebellum; Cyclic AMP; Cycloleucine; Dihydropyridines; Glutamic Acid; GTP-Binding Proteins; Mice; Neurotoxins; Nifedipine; Pertussis Toxin; Protein Kinases; Receptors, Metabotropic Glutamate; Second Messenger Systems; Up-Regulation; Virulence Factors, Bordetella | 1994 |
Activation of postsynaptic metabotropic glutamate receptors by trans-ACPD hyperpolarizes neurons of the basolateral amygdala.
Topics: Action Potentials; Amygdala; Animals; Calcium; Cells, Cultured; Cycloleucine; Male; Membrane Potentials; Neurons; Neurotoxins; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1994 |
Metabotropic glutamate receptors are involved in the control of breathing at the medulla oblongata level of anaesthetized rats.
Topics: Alanine; Anesthesia; Animals; Blood Pressure; Cycloleucine; Glutamic Acid; Injections; Male; Medulla Oblongata; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Respiratory Mechanics; Solitary Nucleus | 1994 |
Metabotropic glutamate receptors modulate N-methyl-D-aspartate receptor function in neostriatal neurons.
Topics: Action Potentials; Alanine; Animals; Cycloleucine; Iontophoresis; Male; Microelectrodes; N-Methylaspartate; Neostriatum; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses | 1994 |
Metabotropic glutamate receptor activation decreases epileptiform activity in rat neocortex.
Topics: Aminobutyrates; Animals; Bicuculline; Cerebral Cortex; Cycloleucine; Epilepsy; Evoked Potentials; Female; GABA-A Receptor Antagonists; In Vitro Techniques; Male; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1994 |
Role of arachidonic acid in the facilitation of glutamate release from rat cerebrocortical synaptosomes independent of metabotropic glutamate receptor responses.
Topics: 4-Aminopyridine; Animals; Arachidonic Acid; Cerebral Cortex; Cycloleucine; Diglycerides; Glutamic Acid; In Vitro Techniques; Male; Nerve Endings; Neurotoxins; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Signal Transduction; Synaptosomes | 1994 |
Glutamate stimulates the phosphorylation of glial fibrillary acidic protein in slices of immature rat hippocampus via a metabotropic receptor.
Topics: Animals; Autoradiography; Cycloleucine; Electrophoresis, Gel, Two-Dimensional; Excitatory Amino Acid Agonists; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kinetics; Male; Neurotoxins; Phosphates; Phosphoproteins; Phosphorylation; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1994 |
The depolarization-induced outflow of D-[3H]aspartate from rat brain slices is modulated by metabotropic glutamate receptors.
Topics: Animals; Aspartic Acid; Brain; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Cycloleucine; Gene Expression; In Situ Hybridization; In Vitro Techniques; Kinetics; Male; Neurotoxins; Phosphatidylinositols; Potassium; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; RNA Probes; RNA, Messenger; Transfection | 1994 |
Is the heterologous expression of metabotropic glutamate receptors (mGluRs) an appropriate method to study the mGluR function? Experience with human embryonic kidney 293 cells transfected with mGluR1.
Topics: Alternative Splicing; Blotting, Northern; Calcium; Cell Division; Cell Line; Cell Survival; Colforsin; Cycloleucine; Embryo, Mammalian; Gene Expression; Glutamic Acid; Humans; Inositol Phosphates; Kidney; Neurotoxins; Pertussis Toxin; Receptors, Metabotropic Glutamate; RNA, Messenger; Thymidine; Transfection; Virulence Factors, Bordetella | 1994 |
Cortical layer-specific effects of the metabotropic glutamate receptor agonist 1S,3R-ACPD in rat primary somatosensory cortex in vivo.
Topics: Aminobutyrates; Animals; Benzoates; Cycloleucine; Glycine; Iontophoresis; Male; Neurons; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Somatosensory Cortex; Synapses | 1994 |
Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptors.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Cycloleucine; Cysteic Acid; Cysteine; Dose-Response Relationship, Drug; Glutamates; Homocysteine; Inositol Phosphates; Kinetics; Mice; Neurons; Neurotransmitter Agents; Receptors, N-Methyl-D-Aspartate; Virulence Factors, Bordetella | 1994 |
Modulation of cyclic AMP formation by putative metabotropic receptor agonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Cerebral Cortex; Colforsin; Cyclic AMP; Cycloleucine; Guinea Pigs; Hydrolysis; In Vitro Techniques; Phosphatidylinositols; Receptors, Metabotropic Glutamate | 1994 |
Reduction of resting K+ current by metabotropic glutamate and muscarinic receptors in rat CA3 cells: mediation by G-proteins.
Topics: Animals; Cell Line; Cloning, Molecular; Cycloleucine; GTP-Binding Proteins; Neurons; Oxidation-Reduction; Potassium Channels; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Muscarinic | 1994 |
The effect of trans-ACPD, a metabotropic excitatory amino acid receptor agonist, on the responses of primate spinothalamic tract neurons.
Topics: Action Potentials; Amino Acids; Animals; Cycloleucine; Hot Temperature; Macaca fascicularis; Microdialysis; Neural Pathways; Neurons; Neurotoxins; Physical Stimulation; Receptors, Metabotropic Glutamate; Spinal Cord; Thalamus | 1994 |
Induction of an olfactory memory by the activation of a metabotropic glutamate receptor.
Topics: Animals; Cycloleucine; Cyclopropanes; Estrus; Female; gamma-Aminobutyric Acid; Glycine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Neuronal Plasticity; Olfactory Bulb; Phentolamine; Pheromones; Pregnancy; Pregnancy, Animal; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Sexual Behavior, Animal | 1994 |
3,5-dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus.
Topics: Aging; Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Colforsin; Cyclic AMP; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; Kinetics; Male; Neurotoxins; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Resorcinols; Second Messenger Systems | 1994 |
Adenosine enhances intracellular Ca2+ mobilization in conjunction with metabotropic glutamate receptor activation by t-ACPD in cultured hippocampal astrocytes.
Topics: Adenosine; Animals; Astrocytes; Calcium; Cells, Cultured; Cycloleucine; Drug Synergism; Hippocampus; Neurotoxins; Purinergic P1 Receptor Antagonists; Rats; Receptors, Metabotropic Glutamate | 1994 |
Presynaptic depression of synaptic transmission mediated by activation of metabotropic glutamate receptors in rat neocortex.
Topics: Aminobutyrates; Animals; Benzoates; Cycloleucine; Electrophysiology; Female; Frontal Lobe; Glycine; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Presynaptic; Synaptic Transmission | 1994 |
Trans-(+-)-1-amino-1,3-cyclopentanedicarboxylate (trans-ACPD) stimulates cAMP accumulation in rat cerebral cortical slices but not in glial or neuronal cultures.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cycloleucine; In Vitro Techniques; Neuroglia; Neurons; Neurotoxins; Rats; Rats, Wistar; Stimulation, Chemical | 1994 |
Induction of cerebellar long-term depression requires activation of glutamate metabotropic receptors.
Topics: Aniline Compounds; Animals; Benzoates; Biotransformation; Cerebellum; Cyclic GMP; Cycloleucine; Cyclopropanes; Evoked Potentials; Fluorescent Dyes; Glycine; In Vitro Techniques; Nerve Fibers; Neuronal Plasticity; Neurotoxins; Purkinje Cells; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Xanthenes | 1994 |
Interaction between metabotropic receptors and purinergic transmission in rat hippocampal slices.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Colforsin; Cycloleucine; Cyclopropanes; Glycine; Hippocampus; In Vitro Techniques; Male; Neurotoxins; Purines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1994 |
Kainate-induced status epilepticus leads to a delayed increase in various specific glutamate metabotropic receptor responses in the hippocampus.
Topics: Animals; Carbachol; Cycloleucine; Hippocampus; Hydrolysis; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Status Epilepticus; Synaptosomes | 1994 |
Trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons.
Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Cytophotometry; Dendrites; Electric Stimulation; Excitatory Amino Acid Antagonists; Fetus; GTP-Binding Proteins; Membrane Potentials; Mice; Neurotoxins; Purkinje Cells; Receptors, N-Methyl-D-Aspartate; Sodium; Synaptic Transmission | 1994 |
Inhibitors of metabotropic glutamate receptors produce amnestic effects in chicks.
Topics: Aminobutyrates; Amnesia; Animals; Avoidance Learning; Benzoates; Chickens; Cycloleucine; Cyclopropanes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glycine; Injections, Intraperitoneal; Injections, Intraventricular; Male; Motor Activity; Phosphoserine; Receptors, Metabotropic Glutamate | 1994 |
(+-)-1-Amino-1,3-cyclopentane-trans-dicarboxylic acid (trans-ACPD) induced inositol triphosphoric acid formation in the brain of iron-induced epileptic rats and epileptic El mice.
Topics: Animals; Brain; Chlorides; Cycloleucine; Disease Models, Animal; Epilepsy; Ferric Compounds; Inositol 1,4,5-Trisphosphate; Male; Mice; Neurotoxins; Rats; Rats, Sprague-Dawley | 1994 |
Metabotropic glutamate receptor agonist ACPD inhibits some, but not all, muscarinic-sensitive K+ conductances in basolateral amygdaloid neurons.
Topics: Action Potentials; Amplifiers, Electronic; Amygdala; Animals; Calcium; Cycloleucine; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Neurotoxins; Parasympathomimetics; Potassium Channels; Pyramidal Cells; Rats; Receptors, Metabotropic Glutamate; Tetrodotoxin | 1994 |
Quisqualate and ACPD are agonists for a glutamate-activated current in identified Aplysia neurons.
Topics: Animals; Aplysia; Cells, Cultured; Cycloleucine; Dose-Response Relationship, Drug; Ganglia; Glutamates; Glutamic Acid; Membrane Potentials; Neural Inhibition; Neurons; Potassium Channels; Quisqualic Acid; Receptors, Glutamate; Synaptic Transmission | 1993 |
Pharmacology of metabotropic glutamate receptor inhibition of cyclic AMP formation in the adult rat hippocampus.
Topics: Alanine; Animals; Colforsin; Cyclic AMP; Cycloleucine; Glutamates; Glutamic Acid; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1993 |
Glutamate uptake system in the presynaptic vesicle: glutamic acid analogs as inhibitors and alternate substrates.
Topics: Animals; Cattle; Cerebral Cortex; Cycloleucine; Cysteine; Glutamates; Glutamic Acid; Synaptic Vesicles; Tryptophan | 1993 |
Glutamate metabotropic receptor mediated depression of synaptic inputs to lamprey reticulospinal neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Axons; Cycloleucine; Electric Stimulation; Electrophysiology; Evoked Potentials; GTP-Binding Proteins; Ketamine; Lampreys; Microelectrodes; N-Methylaspartate; Neurons; Receptors, Glutamate; Reticular Formation; Rhombencephalon; Spinal Cord; Synapses | 1993 |
Pharmacological characterization of metabotropic glutamate receptors in cultured cerebellar granule cells.
Topics: Alanine; Amino Acids, Diamino; Animals; Cells, Cultured; Cerebellum; Cyanobacteria Toxins; Cycloleucine; Drug Interactions; Enzyme Activation; Glutamates; Glutamic Acid; Ibotenic Acid; Magnesium; N-Methylaspartate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Quisqualic Acid; Rats; Receptors, Glutamate | 1993 |
L-2-amino-4-phosphonobutanoic acid and 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid reduce paired-pulse depression recorded from medial perforant path in the dentate gyrus of rat hippocampal slices.
Topics: Aminobutyrates; Animals; Atropine; Baclofen; Carbachol; Cycloleucine; Depression, Chemical; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neural Pathways; Neurotransmitter Uptake Inhibitors; Picrotoxin; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Theophylline | 1993 |
Multiple subtypes of excitatory amino acid receptors coupled to the hydrolysis of phosphoinositides in rat brain.
Topics: Animals; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Cycloleucine; Glutamates; Glutamic Acid; Hippocampus; Hydrolysis; Ibotenic Acid; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, Glutamate | 1993 |
Attenuation of excitatory amino acid toxicity by metabotropic glutamate receptor agonists and aniracetam in primary cultures of cerebellar granule cells.
Topics: Animals; Cell Death; Cells, Cultured; Cerebellum; Cyclic AMP; Cycloleucine; Drug Synergism; Glutamates; Glutamic Acid; Inositol Phosphates; Kainic Acid; Pyrrolidinones; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1993 |
Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination.
Topics: Animals; Cattle; Cycloleucine; Female; Glutamates; Glutamic Acid; Mutagenesis, Site-Directed; Neurotoxins; Oocytes; Quisqualic Acid; Receptors, Glutamate; Recombinant Fusion Proteins; Restriction Mapping; Xenopus | 1993 |
Glutamate activates phospholipase D in hippocampal slices of newborn and adult rats.
Topics: Aging; Animals; Animals, Newborn; Cycloleucine; Enzyme Activation; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Phospholipase D; Rats | 1993 |
Intracerebral 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) produces limbic seizures that are not blocked by ionotropic glutamate receptor antagonists.
Topics: Animals; Anticonvulsants; Cycloleucine; Dose-Response Relationship, Drug; Hippocampus; Injections; Limbic System; Male; Mice; Receptors, Amino Acid; Receptors, Metabotropic Glutamate; Seizures; Signal Transduction; Stereoisomerism; Thalamus | 1993 |
Multiphasic responses of cerebellar Purkinje cells to 1S,3R-ACPD: an in vivo study.
Topics: Action Potentials; Animals; Cycloleucine; Iontophoresis; Male; Neurotoxins; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1993 |
Phenylglycine derivatives antagonize the excitatory response to Purkinje cells to 1S,3R-ACPD: an in vivo and in vitro study.
Topics: Action Potentials; Animals; Benzoates; Cerebellum; Cycloleucine; Electrophysiology; Glycine; In Vitro Techniques; Iontophoresis; Male; Neurotoxins; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1993 |
A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation.
Topics: Animals; Benzoates; Carbazoles; Cycloleucine; Glycine; Hippocampus; In Vitro Techniques; Indole Alkaloids; Long-Term Potentiation; Protein Kinase Inhibitors; Protein Kinases; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 1994 |
Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors.
Topics: Aminobutyrates; Animals; Animals, Newborn; Benzoates; Cerebral Cortex; Colforsin; Cyclic AMP; Cycloleucine; Electrophysiology; Glycine; Guinea Pigs; Neurotoxins; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1994 |
Glutamate receptor agonists stimulate diverse calcium responses in different types of cultured rat cortical glial cells.
Topics: Animals; Animals, Newborn; Base Sequence; Calcium; Calcium-Transporting ATPases; Cells, Cultured; Cerebral Cortex; Cycloleucine; DNA Primers; Fura-2; Ganglia, Spinal; Glial Fibrillary Acidic Protein; Immunohistochemistry; Kainic Acid; Kinetics; Macromolecular Substances; Membrane Potentials; Molecular Sequence Data; Neuroglia; Neurotoxins; Polymerase Chain Reaction; Rats; Receptors, Glutamate; Terpenes; Thapsigargin | 1994 |
Excitatory amino acids (EAAs) stimulate phosphatidylinositol turnover in adult rat striatal slices: interaction between NMDA and EAA metabotropic receptors.
Topics: Amino Acids; Animals; Calcium; Corpus Striatum; Cycloleucine; Drug Interactions; Extracellular Space; In Vitro Techniques; Male; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Time Factors | 1994 |
A cyclic AMP-dependent form of associative synaptic plasticity induced by coactivation of beta-adrenergic receptors and metabotropic glutamate receptors in rat hippocampus.
Topics: Animals; Cyclic AMP; Cycloleucine; Drug Synergism; Electrophysiology; Evoked Potentials; Hippocampus; Isoproterenol; Male; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Metabotropic Glutamate; Synapses | 1994 |
The effects of the metabotropic glutamate receptor agonist 1S,3R-ACPD on neurones in the rat primary somatosensory cortex in vivo.
Topics: Action Potentials; Aminobutyrates; Animals; Cycloleucine; Extracellular Space; Iontophoresis; Male; Neurons; Neurotoxins; Physical Stimulation; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex | 1994 |
Evidence for a role of metabotropic glutamate receptors in sustained nociceptive inputs to rat dorsal horn neurons.
Topics: Animals; Cycloleucine; Glutamates; Hindlimb; Isothiocyanates; Male; Neurons; Neurotoxins; Nociceptors; Pain Measurement; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Spinal Cord | 1994 |
The characteristics and pharmacology of olfactory cortical LTP induced by theta-burst high frequency stimulation and 1S,3R-ACPD.
Topics: Animals; Cerebral Cortex; Cycloleucine; Electric Stimulation; In Vitro Techniques; Long-Term Potentiation; Male; Mice; Neurotoxins; Olfactory Pathways; Receptors, Metabotropic Glutamate; Synaptic Transmission; Theta Rhythm | 1994 |
(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) induces burst firing via an inositol-1,4,5-triphosphate-independent pathway at rat dorsolateral septal nucleus.
Topics: Action Potentials; Animals; Cycloleucine; Electrophysiology; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Neurons; Neurotoxins; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Type C Phospholipases | 1994 |
Potentiation of cAMP responses by metabotropic glutamate receptors depresses excitatory synaptic transmission by a kinase-independent mechanism.
Topics: Alkaloids; Analysis of Variance; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloleucine; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Isoproterenol; Male; Models, Neurological; Neurons; Neurotoxins; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Glutamate; Staurosporine; Synapses; Synaptic Transmission | 1994 |
4-Bromohomoibotenic acid selectively activates a 1-aminocyclopentane-1S,3R-dicarboxylic acid-insensitive metabotropic glutamate receptor coupled to phosphoinositide hydrolysis in rat cortical slices.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cerebral Cortex; Cyclic AMP; Cycloleucine; Drug Resistance; Enzyme Activation; Hydrolysis; Ibotenic Acid; Male; Phosphatidylinositols; Phospholipase D; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1994 |
Effects of t-ACPD on neural survival and second messengers in cultured cerebral cortical neurones.
Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Cycloleucine; Hydrolysis; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Neurons; Phosphatidylinositols; Receptors, Metabotropic Glutamate; Second Messenger Systems | 1993 |
Reduction of phosphoinositide hydrolysis by L-amino-3-phosphonopropionate may be caused by the inhibition of synthesis of phosphatidylinositols.
Topics: Alanine; Animals; Atropine; Carbachol; Cycloleucine; Depression, Chemical; Hippocampus; Hydrolysis; In Vitro Techniques; Inositol; Lithium Chloride; Male; Phosphatidylinositols; Rats; Rats, Wistar | 1993 |
Presynaptic inhibitory action of a metabotropic glutamate receptor agonist on excitatory transmission in visual cortical neurons.
Topics: Animals; Bicuculline; Cycloleucine; Electric Stimulation; Evoked Potentials; In Vitro Techniques; Membrane Potentials; Neurons; Neurotoxins; Rats; Receptors, Glutamate; Strychnine; Synaptic Transmission; Tetrodotoxin; Time Factors; Visual Cortex | 1993 |
Co-administration of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid and arachidonic acid potentiates synaptic transmission in rat hippocampal slices.
Topics: Animals; Arachidonic Acid; Cycloleucine; Drug Synergism; Hippocampus; In Vitro Techniques; Rats; Stereoisomerism; Synaptic Transmission | 1993 |
A new metabotropic glutamate receptor agonist: developmental change of its sensitivity to receptors in the newborn rat spinal cord.
Topics: Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Baclofen; Cycloleucine; Cyclopropanes; Dose-Response Relationship, Drug; Glycine; In Vitro Techniques; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Spinal Cord; Synapses | 1993 |
Mediation of thalamic sensory responses in vivo by ACPD-activated excitatory amino acid receptors.
Topics: Animals; Cycloleucine; Electrophysiology; Male; Neurons; Nociceptors; Physical Stimulation; Rats; Rats, Wistar; Receptors, Amino Acid; Sensation; Thalamus | 1993 |
Characterization of a calcium-dependent current generating a slow afterdepolarization of CA3 pyramidal cells in rat hippocampal slice cultures.
Topics: Animals; Calcium; Chlorides; Culture Techniques; Cycloleucine; Electric Conductivity; Electrophysiology; Hippocampus; Potassium; Rats; Sodium | 1993 |
Agonist-induced, GTP-dependent phosphoinositide hydrolysis in postmortem human brain membranes.
Topics: Adenosine Triphosphate; Aged; Aluminum Compounds; Brain; Calcium; Carbachol; Cell Membrane; Cycloleucine; Female; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histamine; Humans; Hydrolysis; Male; Neurotoxins; Phosphatidylinositols; Pilocarpine; Postmortem Changes; Second Messenger Systems; Serotonin; Type C Phospholipases | 1994 |
Interaction of zinc with ionotropic and metabotropic glutamate receptors in rat hippocampal slices.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Neurotoxins; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Zinc | 1993 |
Heterogeneity of metabotropic glutamate receptors in the striatum: electrophysiological evidence.
Topics: Alanine; Aminobutyrates; Animals; Cerebral Cortex; Corpus Striatum; Cycloleucine; Electric Stimulation; Evoked Potentials; In Vitro Techniques; Lithium Chloride; Neuronal Plasticity; Organophosphorus Compounds; Rats; Rats, Wistar; Receptors, Glutamate; Stereoisomerism; Synapses | 1993 |
Microinjections of the metabotropic glutamate receptor agonist, trans-(+/-)-1-amino-cyclopentane-1,3-dicarboxylate (trans-ACPD) into the amygdala increase the acoustic startle response of rats.
Topics: Acoustic Stimulation; Amygdala; Animals; Brain Mapping; Cycloleucine; Male; Microinjections; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Reflex, Startle; Time Factors | 1993 |
Pharmacological characterization of the metabotropic glutamate receptor inhibiting D-[3H]-aspartate output in rat striatum.
Topics: Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Colforsin; Corpus Striatum; Cyclic AMP; Cycloleucine; In Vitro Techniques; Male; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate | 1993 |
Metabotropic receptor stimulation coupled to weak tetanus leads to long-term potentiation and a rapid elevation of cytosolic protein kinase C activity.
Topics: Animals; Cycloleucine; Cytosol; Enzyme Activation; Male; Neuronal Plasticity; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Tetanus; Time Factors | 1993 |
Functional evidence for a L-AP3-sensitive metabotropic receptor different from glutamate metabotropic receptor mGluR1.
Topics: Alanine; Animals; Cells, Cultured; Cerebellum; Culture Media; Cycloleucine; Granulocytes; Inositol Phosphates; Neurons; Osmolar Concentration; Potassium Chloride; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; RNA, Messenger | 1993 |
Trans-azetidine-2,4-dicarboxylic acid activates neuronal metabotropic receptors.
Topics: Animals; Azetidinecarboxylic Acid; Cell Line; Cells, Cultured; Cerebellum; Cycloleucine; DNA; Down-Regulation; Female; Humans; Inositol Phosphates; Kidney; Neurons; Neurotoxins; Potassium Chloride; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Transfection | 1993 |
Endogenous adenosine regulates the apparent efficacy of 1-aminocyclopentyl-1S,3R-dicarboxylate inhibition of forskolin-stimulated cyclic AMP accumulation in rat cerebral cortical slices.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cerebral Cortex; Colforsin; Cyclic AMP; Cycloleucine; Female; In Vitro Techniques; Kinetics; Male; Neurotoxins; Rats; Rats, Inbred Strains; Xanthines | 1993 |
Activation of metabotropic glutamate receptors increases cAMP accumulation in hippocampus by potentiating responses to endogenous adenosine.
Topics: Adenosine; Adenosine Deaminase; Animals; Cyclic AMP; Cycloleucine; Drug Synergism; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Purinergic | 1993 |
Characterisation of LTP induced by the activation of glutamate metabotropic receptors in area CA1 of the hippocampus.
Topics: Alkaloids; Animals; Calcium-Transporting ATPases; Cycloleucine; Electric Stimulation; Hippocampus; In Vitro Techniques; Neuronal Plasticity; Phosphatidylinositols; Protein Kinase C; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Staurosporine; Stereoisomerism; Synapses; Terpenes; Thapsigargin | 1993 |
(1S, 3R)-ACPD protects synaptic transmission from hypoxia in hippocampal slices.
Topics: Alanine; Animals; Cycloleucine; Evoked Potentials; Excitatory Amino Acid Antagonists; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Rats; Rats, Wistar; Synapses; Synaptic Transmission | 1993 |
Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine.
Topics: Animals; Animals, Newborn; Benzoates; Cerebral Cortex; Chromatography, High Pressure Liquid; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Phosphatidylinositols; Rats; Spinal Cord; Synapses; Thalamus | 1993 |
Coactivation of metabotropic and NMDA receptors is required for LTP induction.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alanine; Animals; Carbachol; Cyclic AMP; Cycloleucine; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Thionucleotides | 1993 |
L-AP3 does not antagonize hippocampal synaptic depression induced by 1S,3R-ACPD.
Topics: Alanine; Animals; Cycloleucine; Dendrites; Evoked Potentials; Extracellular Space; Hippocampus; In Vitro Techniques; Phosphatidylinositols; Rats; Rats, Wistar; Synapses | 1993 |
Inhibitory glutamate response on cyclic AMP formation in cultured astrocytes.
Topics: Adenylate Cyclase Toxin; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Colforsin; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; Iodine Radioisotopes; Isoproterenol; Pertussis Toxin; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Virulence Factors, Bordetella | 1993 |
Differential localization of phosphoinositide-linked metabotropic glutamate receptor (mGluR1) and the inositol 1,4,5-trisphosphate receptor in rat brain.
Topics: Animals; Brain; Calcium Channels; Cycloleucine; Immunohistochemistry; In Situ Hybridization; Inositol 1,4,5-Trisphosphate Receptors; Male; Microscopy, Electron; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Glutamate; RNA, Messenger; Tissue Distribution | 1993 |
Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R-ACPD.
Topics: Acetylcholine; Animals; Cerebral Cortex; Cycloleucine; Electrophysiology; Female; Guinea Pigs; In Vitro Techniques; Male; Neurons; Norepinephrine; Pons; Superior Colliculi; Synaptic Transmission | 1993 |
Properties of a presynaptic metabotropic glutamate receptor in rat neostriatal slices.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium; Corpus Striatum; Cycloleucine; Extracellular Space; In Vitro Techniques; Neurons; Rats; Receptors, Glutamate; Synapses; Synaptic Transmission | 1993 |
A cAMP-linked metabotropic glutamate receptor in hippocampus.
Topics: Action Potentials; Animals; Cyclic AMP; Cycloleucine; Hippocampus; Male; Membrane Potentials; Rats; Rats, Wistar; Receptors, Glutamate | 1993 |
Subtypes of metabotropic excitatory amino acid receptor distinguished by stereoisomers of the rigid glutamate analogue, 1-aminocyclopentane-1,3-dicarboxylate.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cerebral Cortex; Colforsin; Cyclic AMP; Cycloleucine; Glutamates; Guinea Pigs; In Vitro Techniques; Phosphatidylinositols; Receptors, Amino Acid; Receptors, Purinergic; Stereoisomerism | 1993 |
Zinc protoporphyrin-IX blocks the effects of metabotropic glutamate receptor activation in the rat nucleus tractus solitarii.
Topics: Action Potentials; Animals; Brain Stem; Cyclic GMP; Cycloleucine; Electrophysiology; Heme Oxygenase (Decyclizing); Neurotoxins; Protoporphyrins; Rats; Receptors, GABA-A; Receptors, Glutamate | 1993 |
Polyamines modulate the function of transfected glutamate receptor mGluR1a.
Topics: Biogenic Polyamines; Cell Line; Cycloleucine; Female; Humans; Hydrolysis; Kidney; Phosphatidylinositols; Pregnancy; Putrescine; Receptors, Glutamate; Spermidine; Spermine; Transfection | 1993 |
Pharmacological differentiation of metabotropic glutamate receptors coupled to potentiation of cyclic adenosine monophosphate responses and phosphoinositide hydrolysis.
Topics: Animals; Brain; Cyclic AMP; Cycloleucine; Hydrolysis; In Vitro Techniques; Male; Phosphatidylinositols; Phosphoserine; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Vasoactive Intestinal Peptide | 1993 |
Excitatory amino acid receptor-stimulated phosphoinositide turnover in primary cerebrocortical cultures.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cycloleucine; Female; GTP-Binding Proteins; Kynurenic Acid; Pertussis Toxin; Phosphatidylinositols; Piperazines; Pregnancy; Quinoxalines; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Virulence Factors, Bordetella | 1993 |
Glutamate metabotropic receptor activation in neonatal rat cerebral cortex by sulphur-containing excitatory amino acids.
Topics: Amino Acids, Sulfur; Animals; Animals, Newborn; Biotransformation; Cerebral Cortex; Cycloleucine; In Vitro Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Glutamate | 1993 |
Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in rat hippocampal slices.
Topics: Animals; Arachidonic Acid; Calcium; Cyclic AMP; Cycloleucine; Drug Synergism; Enzyme Activation; Female; Hippocampus; In Vitro Techniques; Magnesium; N-Methylaspartate; Neuronal Plasticity; Neurotoxins; Protein Kinase C; Rats; Receptors, Glutamate; Signal Transduction; Stereoisomerism; Tetrodotoxin | 1993 |
A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord.
Topics: Amino Acids; Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Cycloleucine; Cyclopropanes; Electric Stimulation; Electrophysiology; Glycine; In Vitro Techniques; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Reflex, Monosynaptic; Spinal Cord | 1993 |
Stimulation of phosphoinositide hydrolysis by trans-(+/-)-ACPD is greatly enhanced when astrocytes are cultured in a serum-free defined medium.
Topics: Animals; Astrocytes; Cells, Cultured; Culture Media, Serum-Free; Cycloleucine; Hydrolysis; Phosphatidylinositols; Rats; Receptors, Metabotropic Glutamate | 1993 |
Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Benzodiazepines; Brain Injuries; Cell Nucleus; Corpus Striatum; Cycloleucine; Dantrolene; Dizocilpine Maleate; Female; Hippocampus; Male; Microscopy, Electron; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Seizures; Stereotaxic Techniques | 1993 |
In rats, the metabotropic glutamate receptor-triggered hippocampal neuronal damage is strain-dependent.
Topics: Animals; Behavior, Animal; Brain Diseases; Cycloleucine; Drug Synergism; Hippocampus; Male; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Inbred BN; Rats, Inbred F344; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptors, Glutamate | 1993 |
Metabotropic glutamate receptors in the ventrolateral medulla of rats.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Amino Acids; Animals; Blood Pressure; Cycloleucine; Dose-Response Relationship, Drug; Drug Combinations; Male; Medulla Oblongata; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Stimulation, Chemical | 1993 |
Lithium treatment blocks long-term synaptic depression in the striatum.
Topics: Animals; Carbachol; Cell Membrane; Corpus Striatum; Cycloleucine; Lithium; Membrane Potentials; Neurons; Rats; Rats, Wistar; Synapses | 1993 |
Serotonin depresses excitatory amino acid-induced excitation of cerebellar Purkinje cells in the adult rat in vivo.
Topics: Action Potentials; Amino Acids; Animals; Cycloleucine; Male; Microcomputers; Nervous System; Purkinje Cells; Rats; Rats, Sprague-Dawley; Serotonin | 1993 |
Co-activation of metabotropic glutamate and N-methyl-D-aspartate receptors is involved in mechanisms of long-term potentiation maintenance in rat hippocampal CA1 neurons.
Topics: Alanine; Animals; Cycloleucine; Electrophysiology; Hippocampus; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses | 1993 |
Characterization of the glutamate receptors mediating release of somatostatin from cultured hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Cycloleucine; Dizocilpine Maleate; Drug Synergism; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Somatostatin; Tetrodotoxin | 1996 |
Calcium ion impedes translation initiation at the synapse.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cerebral Cortex; Cycloleucine; Depression, Chemical; Gene Expression Regulation; Ionophores; Long-Term Potentiation; N-Methylaspartate; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Protein Biosynthesis; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Ribosomes; RNA, Messenger; Sulfonamides; Synapses | 1996 |
[Activation of nitric oxide formation mediated by metabotropic glutamate receptors in primary cultures of cerebellar granule cells].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcium; Cells, Cultured; Cerebellum; Cycloleucine; Cytoplasmic Granules; Enzyme Activation; Guanylate Cyclase; Nitric Oxide; Nitric Oxide Synthase; Receptors, Metabotropic Glutamate | 1995 |
On the mechanism of long-term potentiation induced by (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) in rat hippocampal slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium Channel Blockers; Cycloleucine; Evoked Potentials; Excitatory Amino Acid Agonists; Female; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Nimodipine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic | 1995 |
Pharmacology of metabotropic glutamate receptor-mediated enhancement of responses to excitatory and inhibitory amino acids on rat spinal neurones in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cycloleucine; Electrophoresis; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Spinal Cord | 1995 |
Interactions between metabotropic and ionotropic glutamate receptor agonists in the rat spinal cord in vivo.
Topics: Action Potentials; Animals; Blood Pressure; Cycloleucine; Electrophoresis; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Male; Neurons; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord | 1995 |
The involvement of metabotropic glutamate receptors and their intracellular signalling pathways in sustained nociceptive transmission in rat dorsal horn neurons.
Topics: Animals; Cycloleucine; Extracellular Space; In Vitro Techniques; Iontophoresis; Male; Mustard Plant; Neurons; Pain; Physical Stimulation; Plant Extracts; Plant Oils; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Signal Transduction; Spinal Cord; Synaptic Transmission | 1995 |
1S,3R-ACPD dose-dependently induces a slow-onset potentiation in the rat hippocampal CA1 region in vivo.
Topics: Animals; Cycloleucine; Evoked Potentials; Hippocampus; In Vitro Techniques; Injections, Intraventricular; Male; Neuronal Plasticity; Rats; Rats, Wistar; Synaptic Transmission | 1995 |
Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; ATP-Binding Cassette Transporters; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Hydrolysis; In Vitro Techniques; Male; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1995 |
New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord.
Topics: Aminobutyrates; Animals; Animals, Newborn; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; Motor Neurons; Rats; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Spinal Cord; Tetrodotoxin | 1995 |
1S,3R-ACPD-preferring inward current in rat dorsolateral septal neurons is mediated by a novel excitatory amino acid receptor.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cycloleucine; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Pertussis Toxin; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Temperature; Virulence Factors, Bordetella | 1995 |
Metabotropic glutamate receptor modulation of synaptic transmission in corticostriatal co-cultures: role of calcium influx.
Topics: Animals; Calcium; Cerebral Cortex; Coculture Techniques; Cycloleucine; Electrophysiology; Immunohistochemistry; Ion Channel Gating; Neostriatum; Pertussis Toxin; Phorbol Esters; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Virulence Factors, Bordetella | 1995 |
Metabotropic glutamate receptor-induced homosynaptic long-term depression and depotentiation in the dentate gyrus of the rat hippocampus in vitro.
Topics: Animals; Cycloleucine; Dentate Gyrus; Depression, Chemical; Electric Stimulation; Excitatory Amino Acid Antagonists; In Vitro Techniques; Neuronal Plasticity; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic | 1995 |
Metabotropic glutamate receptors in the guinea-pig medial vestibular nucleus in vitro.
Topics: Animals; Cycloleucine; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Neurons; Receptors, Metabotropic Glutamate; Vestibular Nuclei | 1995 |
Modulatory effects of acute ethanol on metabotropic glutamate responses in cultured Purkinje neurons.
Topics: Animals; Cells, Cultured; Cycloleucine; Ethanol; Purkinje Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1995 |
Metabotropic glutamate receptor subtypes differentially influence neuronal recovery from in vitro hypoxia/hypoglycemia in rat hippocampal slices.
Topics: Adenosine Triphosphate; Animals; Cycloleucine; Electrophysiology; Energy Metabolism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Phosphocreatine; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1995 |
Presynaptic actions of glutamate receptor agonists in the CA1 region of rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic | 1995 |
A comparison of the effects of selective metabotropic glutamate receptor agonists on synaptically evoked whole cell currents of rat spinal ventral horn neurones in vitro.
Topics: Aminobutyrates; Animals; Anterior Horn Cells; Cycloleucine; Depression, Chemical; Excitatory Amino Acid Agonists; N-Methylaspartate; Neurons; Neurotoxins; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1995 |
Respiratory effects produced by microinjection of L-glutamate and an uptake inhibitor of L-glutamate into the caudal subretrofacial area of the medulla.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Apnea; Blood Pressure; Cats; Cycloleucine; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Heart Rate; Kynurenic Acid; Male; Neurotoxins; Neurotransmitter Uptake Inhibitors; Piperazines; Pyrrolidines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Respiration; Respiratory Function Tests; Tidal Volume; Trigeminal Caudal Nucleus | 1995 |
Metabotropic and ionotropic glutamate receptors mediate opposite effects on periaqueductal gray matter.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Blood Pressure; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Microinjections; N-Methylaspartate; Neurons; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate | 1995 |
Sodium-dependent glutamate uptake as an activator of oxidative metabolism in primary astrocyte cultures from newborn rat.
Topics: Animals; Animals, Newborn; Astrocytes; Biotransformation; Cells, Cultured; Cycloleucine; Energy Metabolism; Glutamic Acid; Ketoglutaric Acids; Nerve Tissue Proteins; Oxidation-Reduction; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sodium | 1995 |
Ethylene is a positive regulator of root hair development in Arabidopsis thaliana.
Topics: Arabidopsis; Cycloleucine; Dose-Response Relationship, Drug; Ethylenes; Homeostasis; Plant Roots | 1995 |
Blockade of both epileptogenesis and glutamate release by (1S,3S)-ACPD, a presynaptic glutamate receptor agonist.
Topics: Animals; Cycloleucine; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1995 |
Metabotropic glutamate receptor inhibition of visceral afferent potassium currents.
Topics: 4-Aminopyridine; Animals; Cycloleucine; Ion Channel Gating; Membrane Potentials; Neurons, Afferent; Potassium Channel Blockers; Rats; Receptors, Metabotropic Glutamate; Viscera | 1995 |
Prolonged stimulation of respiration by brain stem metabotropic glutamate receptors.
Topics: Analysis of Variance; Animals; Benzoates; Brain Stem; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; Microinjections; Microscopy, Fluorescence; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Respiration; Stimulation, Chemical | 1995 |
Evidence that Ca/calmodulin-dependent protein kinase mediates the modulation of the Ca2+-dependent K+ current, IAHP, by acetylcholine, but not by glutamate, in hippocampal neurons.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cycloleucine; Hippocampus; Molecular Sequence Data; Neurons; Potassium Channels; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Signal Transduction | 1996 |
Presynaptic inhibition of excitatory synaptic transmission by muscarinic and metabotropic glutamate receptor activation in the hippocampus: are Ca2+ channels involved?
Topics: Animals; Calcium Channels; Cycloleucine; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Methacholine Chloride; Muscarinic Agonists; Potassium; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1995 |
Metabotropic and ionotropic transducers of glutamate signal inversely control cytoplasmic Ca2+ concentration and excitotoxicity in cultured cerebellar granule cells: pivotal role of protein kinase C.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Cycloleucine; Cytosol; Glutamic Acid; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems | 1996 |
Transiently selective activation of phosphoinositide turnover in layer V pyramidal neurons after specific mGluRs stimulation in rat somatosensory cortex during early postnatal development.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Carbachol; Cycloleucine; Female; Lithium; Male; Phosphatidylinositols; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Silver; Somatosensory Cortex; Time Factors | 1995 |
Synchronized oscillations in hippocampal CA3 neurons induced by metabotropic glutamate receptor activation.
Topics: Animals; Cycloleucine; Electric Stimulation; Electrophysiology; Female; GABA Antagonists; Hippocampus; Male; Neurons; Neurotoxins; Oscillometry; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, Metabotropic Glutamate; Synapses; Time Factors | 1995 |
Metabotropic glutamate receptor modulation of voltage-gated Ca2+ channels involves multiple receptor subtypes in cortical neurons.
Topics: Animals; Benzoates; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Cycloleucine; Cyclopropanes; Electrophysiology; Ethylmaleimide; Excitatory Amino Acid Agonists; Glycine; Ion Channel Gating; Neurons; Neurotoxins; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spider Venoms | 1996 |
Components of glial responses to exogenous and synaptic glutamate in rat hippocampal microcultures.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cells, Cultured; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Microglia; Neurons; Neurotoxins; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Tacrine | 1996 |
Persistent increase in dopamine release following activation of metabotropic glutamate receptors in the rat nucleus accumbens.
Topics: Animals; Benzoates; Chromatography, High Pressure Liquid; Cycloleucine; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Male; Microdialysis; N-Methylaspartate; Neurotoxins; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1995 |
Glutamate-independent long term depression in rat hippocampus by activation GABAA receptors.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Alanine; Animals; Cycloleucine; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetics; Kynurenic Acid; Male; Muscimol; Neuronal Plasticity; Neurotoxins; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A | 1996 |
The phosphoinositide signal transduction system is impaired in bipolar affective disorder brain.
Topics: Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Bipolar Disorder; Brain Chemistry; Carbachol; Cell Membrane; Cycloleucine; Female; Guanosine 5'-O-(3-Thiotriphosphate); Histamine; Humans; Hydrolysis; Male; Middle Aged; Muscarinic Agonists; Neurotoxins; Phosphatidylinositols; Serotonin; Signal Transduction; Sodium Fluoride; Tritium; Type C Phospholipases | 1996 |
Cellular mechanisms of protection by metabotropic glutamate receptors during anoxia and nitric oxide toxicity.
Topics: Alanine; Aminobutyrates; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction | 1996 |
Modulation of 45Ca2+ influx into cells stably expressing recombinant human NMDA receptors by ligands acting at distinct recognition sites.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Calcium; Calcium Radioisotopes; Cycloleucine; Dithionitrobenzoic Acid; Dithiothreitol; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Humans; Kainic Acid; L Cells; Ligands; Mice; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermine; Sulfhydryl Reagents | 1996 |
(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase.
Topics: Adenylyl Cyclases; Amino Acids, Dicarboxylic; Animals; Binding, Competitive; Brain; Cell Line; Cell Membrane; Cycloleucine; Glutamic Acid; Humans; Indicators and Reagents; Inositol Phosphates; Kinetics; Neurotoxins; Phosphatidylinositols; Rats; Receptors, Metabotropic Glutamate | 1996 |
Characterization of metabotropic glutamate receptor-mediated facilitation of N-methyl-D-aspartate depolarization of neocortical neurones.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alanine; Alkaloids; Aminobutyrates; Animals; Cerebral Cortex; Cyclic GMP; Cycloleucine; Male; Neurons; Phorbol Esters; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Staurosporine | 1996 |
Calcium signalling in granule neurones studied in cerebellar slices.
Topics: Acetylcholine; Age Factors; Animals; Animals, Newborn; Caffeine; Calcium; Calcium Channel Agonists; Cerebellum; Cycloleucine; Electric Conductivity; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Homeostasis; Ion Channel Gating; Mice; Mice, Inbred CBA; N-Methylaspartate; Neurons; Neurotoxins; Organ Culture Techniques; Phosphodiesterase Inhibitors; Quisqualic Acid; Sensitivity and Specificity; Signal Transduction | 1996 |
Differentiation of group 2 and group 3 metabotropic glutamate receptor cAMP responses in the rat hippocampus.
Topics: Adenosine; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Colforsin; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Vasoactive Intestinal Peptide | 1996 |
Interaction between A1 adenosine and class II metabotropic glutamate receptors in the regulation of purine and glutamate release from rat hippocampal slices.
Topics: Adenosine; Animals; Cycloleucine; Cyclopropanes; Excitatory Amino Acids; Glutamic Acid; Glycine; Hippocampus; Male; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Xanthines | 1996 |
Agonist-evoked Ca2+ mobilization from stores expressing inositol 1,4,5-trisphosphate receptors and ryanodine receptors in cerebellar granule neurones.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Calcium-Binding Proteins; Carbachol; Central Nervous System Stimulants; Cerebellum; Cycloleucine; Down-Regulation; Excitatory Amino Acid Agonists; Female; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Male; Muscle Proteins; N-Methylaspartate; Neurons; Neurotoxins; Nicotinic Agonists; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Ryanodine Receptor Calcium Release Channel; Signal Transduction | 1996 |
The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists.
Topics: Amino Acids, Dicarboxylic; Cell Line; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Humans; Kidney; Neurotoxins; Protein Conformation; Protein Structure, Tertiary; Quisqualic Acid; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Sensitivity and Specificity; Transfection | 1996 |
Characterization of metabotropic glutamate receptor-stimulated phosphoinositide hydrolysis in rat cultured cerebellar granule cells.
Topics: Animals; Cells, Cultured; Cerebellum; Cycloleucine; Excitatory Amino Acid Agonists; Hydrolysis; Neurons; Phosphatidylinositols; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate | 1995 |
Opposing effects on blood pressure following the activation of metabotropic and ionotropic glutamate receptors in raphe obscurus in the anaesthetized rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Benzoates; Blood Pressure; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hypertension; Male; Microinjections; N-Methylaspartate; Neurotoxins; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Valine | 1996 |
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; Cerebral Cortex; Cricetinae; Cyclic AMP; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Kidney; Kinetics; Mice; N-Methylaspartate; Neuroglia; Neurons; Neurotoxins; Phosphatidylinositols; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 1996 |
A metabotropic glutamate receptor agonist DCG-IV suppresses synaptic transmission at mossy fiber pathway of the guinea pig hippocampus.
Topics: Aminobutyrates; Animals; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Agonists; Glycine; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Receptors, Metabotropic Glutamate | 1996 |
Heterologous modulation of inhibitory synaptic transmission by metabotropic glutamate receptors in cultured hippocampal neurons.
Topics: Animals; Benzoates; Cells, Cultured; Cycloleucine; Dicarboxylic Acids; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Neural Inhibition; Neurons; Neurotransmitter Uptake Inhibitors; Patch-Clamp Techniques; Pyrrolidines; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1996 |
Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs).
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Cortex; Colforsin; Cyclic AMP; Cycloleucine; Glycine; Inositol Phosphates; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 1995 |
Influences of hypothyroidism on lipid composition and inositol lipid-linked receptors responsiveness and protein kinase C (PKC) activity in the cerebral cortex of Lewis rats.
Topics: Animals; Carbachol; Cerebral Cortex; Cycloleucine; Hypothyroidism; Inositol; Inositol Phosphates; Male; Neurotoxins; Pirenzepine; Protein Kinase C; Rats; Rats, Inbred Lew; Receptors, Metabotropic Glutamate; Receptors, Muscarinic | 1996 |
Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices.
Topics: 2-Chloroadenosine; Alanine; Aminobutyrates; Animals; Animals, Newborn; Cycloleucine; Depression, Chemical; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Organophosphonates; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrazoles | 1996 |
L-AP4 inhibits high voltage-activated Ca2+ currents in pyramidal cortical neurones.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Barium; Calcium Channel Blockers; Cerebral Cortex; Cycloleucine; Excitatory Amino Acid Agonists; Ion Channel Gating; Male; Microtubule-Associated Proteins; Neurotoxins; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1996 |
Contralateral turning caused by metabotropic glutamate receptor stimulation in the dorsal striatum is reversed by MCPG, TTX, and cis-flupenthixol.
Topics: Animals; Benzoates; Corpus Striatum; Cycloleucine; Dominance, Cerebral; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Flupenthixol; Glycine; Male; Motor Activity; Neurons; Neurotoxins; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stereotyped Behavior; Synaptic Transmission; Tetrodotoxin | 1996 |
Differences in agonist and antagonist activities for two indices of metabotropic glutamate receptor-stimulated phosphoinositide turnover.
Topics: Animals; Benzoates; Cerebral Cortex; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Glycine; Inositol 1,4,5-Trisphosphate; Male; Molecular Conformation; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1996 |
Coupling of metabotropic glutamate receptors to phosphoinositide mobilisation and inhibition of cyclic AMP generation in the guinea-pig cerebellum.
Topics: 2-Chloroadenosine; Animals; Cerebellum; Colforsin; Cyclic AMP; Cycloleucine; Female; Glutamic Acid; Glycine; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Phosphatidylinositols; Receptors, Metabotropic Glutamate; Resorcinols | 1996 |
L-Glutamate-induced responses in OFF-type bipolar cells of the cat retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Calcium; Cats; Chlorides; Cycloleucine; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; In Vitro Techniques; Ion Transport; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Potassium; Retina; Retinal Cone Photoreceptor Cells; Sodium | 1996 |
Patch-clamp study of neurones in rat olfactory cortex slices: properties of a slow post-stimulus afterdepolarizing current (IADP).
Topics: Animals; Cell Count; Cycloleucine; Female; Male; Membrane Potentials; Olfactory Pathways; Oxotremorine; Patch-Clamp Techniques; Rats; Rats, Wistar | 1995 |
Metabotropic glutamate receptors and visual cortical synaptic plasticity.
Topics: Animals; Benzoates; Calcium; Cycloleucine; Evoked Potentials; Excitatory Amino Acid Antagonists; Female; Glycine; In Vitro Techniques; Long-Term Potentiation; Male; Neuronal Plasticity; Neurotoxins; Rats; Receptors, Metabotropic Glutamate; Visual Cortex | 1995 |
Adenosine A2 receptor-mediated modulation of contralateral rotation induced by metabotropic glutamate receptor activation.
Topics: Animals; Behavior, Animal; Caffeine; Cycloleucine; Male; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Rotation; Theophylline | 1995 |
Metabotropic glutamate group II receptors are responsible for the depression of synaptic transmission induced by ACPD in the dentate gyrus.
Topics: Animals; Benzoates; Cycloleucine; Dentate Gyrus; Excitatory Amino Acid Antagonists; Glycine; Male; Rats; Rats, Wistar; Receptors, Glutamate; Synaptic Transmission | 1995 |
1S,3R-ACPD dose dependently induces a slow onset potentiation in the dentate gyrus in vivo.
Topics: Action Potentials; Animals; Benzoates; Cycloleucine; Dentate Gyrus; Dose-Response Relationship, Drug; Glycine; Long-Term Potentiation; Male; Rats; Rats, Wistar; Synaptic Transmission | 1995 |
Functional coupling between ryanodine receptors and L-type calcium channels in neurons.
Topics: Animals; Barium; Caffeine; Calcium Channels; Cells, Cultured; Cerebellum; Cycloleucine; Inositol 1,4,5-Trisphosphate; Membrane Potentials; Mice; Muscle Proteins; Neurons; Phosphodiesterase Inhibitors; Protein Kinases; Receptors, Metabotropic Glutamate; Ryanodine; Ryanodine Receptor Calcium Release Channel; Type C Phospholipases | 1996 |
Time-dependent increase in release of arachidonic acid following passive avoidance training in the day-old chick.
Topics: Age Factors; Animals; Arachidonic Acid; Avoidance Learning; Carbon Radioisotopes; Chickens; Cycloleucine; Excitatory Amino Acid Agonists; Female; Male; N-Methylaspartate; Neurotoxins; Potassium Chloride; Receptors, Glutamate; Signal Transduction; Time Factors | 1996 |
Potentiated cAMP rise in metabotropically stimulated rat cultured astrocytes by a Ca2+-related A1/A2 adenosine receptor cooperation.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Astrocytes; Calcium; Cells, Cultured; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Agonists; Purinergic P1 Receptor Agonists; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stimulation, Chemical | 1996 |
Differential long-lasting potentiation of the NMDA and non-NMDA synaptic currents induced by metabotropic and NMDA receptor coactivation in cerebellar granule cells.
Topics: Animals; Benzoates; Cerebellum; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Long-Term Potentiation; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1996 |
Multiple actions of 1S,3R-ACPD in modulating endogenous synaptic transmission to spinal respiratory motoneurons.
Topics: Animals; Cycloleucine; Electric Conductivity; Motor Neurons; Neurotoxins; Phrenic Nerve; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Respiration; Spinal Cord; Synapses; Synaptic Transmission | 1996 |
Activation of multiple metabotropic glutamate receptor subtypes prevents NMDA-induced excitotoxicity in rat hippocampal slices.
Topics: Animals; Benzoates; Cycloleucine; Excitatory Amino Acid Antagonists; Female; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neuroprotective Agents; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1996 |
(1 S,3 R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced increases in cyclic AMP formation in the neonatal rat hippocampus are mediated by a synergistic interaction between phosphoinositide- and inhibitory cyclic AMP-coupled mGluRs.
Topics: Animals; Animals, Newborn; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; Female; Glycine; Hippocampus; In Vitro Techniques; Male; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols | 1996 |
Activation of metabotropic glutamate receptors induce differential effects on synaptic transmission in the dentate gyrus and CA1 of the hippocampus in the anaesthetized rat.
Topics: Animals; Calcium; Cycloleucine; Dentate Gyrus; Dose-Response Relationship, Drug; Hippocampus; Long-Term Potentiation; Male; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1996 |
Excitatory amino acid-, except 1S,3R-ACPD, induced transient high stimulation of phosphoinositide metabolism during hippocampal neuron development.
Topics: Animals; Cells, Cultured; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Hippocampus; Membrane Lipids; Neurites; Neurons; Neurotoxins; Phosphatidylinositols; Rats; Receptors, Metabotropic Glutamate; Stimulation, Chemical | 1995 |
Interactions between arachidonic acid and metabotropic glutamate receptors in the induction of synaptic potentiation in the rat hippocampal slice.
Topics: Animals; Arachidonic Acid; Cycloleucine; Electric Stimulation; GABA Antagonists; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Melitten; Phospholipases A; Phospholipases A2; Picrotoxin; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1995 |
Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus.
Topics: Analysis of Variance; Animals; Brain; Cycloleucine; Enzyme Induction; Glycerophospholipids; Hippocampus; Male; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Signal Transduction; Stereoisomerism | 1996 |
Intrauterine hypoxia-ischemia reduces phosphoinositide hydrolysis stimulated by metabotropic glutamate receptor agonists in cultured rat cerebellar granule cells.
Topics: Alanine; Animals; Brain Ischemia; Cell Count; Cells, Cultured; Cerebellum; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Fetal Hypoxia; Hydrolysis; Hypoxia, Brain; Neurons; Neurotoxins; omega-N-Methylarginine; Phosphatidylinositols; Pregnancy; Proteins; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1996 |
Is activation of metabotropic glutamate receptors responsible for acute hyposic changes in hippocampal neurons?
Topics: Animals; Cycloleucine; Hippocampus; Hypoxia; Male; Membrane Potentials; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1996 |
Activation of a metabotropic excitatory amino acid receptor potentiates spike-driven calcium increases in neurons of the dorsolateral septum.
Topics: Action Potentials; Animals; Calcium; Cycloleucine; Dendrites; Fluorescent Dyes; Fura-2; Homeostasis; Intracellular Membranes; Male; Neurons; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Septum Pellucidum | 1996 |
Developmental changes in glutamate receptor-activated translocation of protein kinase C in cerebellar granule neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Biological Transport; Carcinogens; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurotoxins; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Tritium | 1996 |
Effects of metabotropic glutamate receptor agonists on excitatory and inhibitory transmissions in cultured rat hippocampal neurons.
Topics: Animals; Animals, Newborn; Benzoates; Cells, Cultured; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Neural Inhibition; Neurons; Neurotoxins; Rats; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Synaptic Transmission | 1995 |
Metabotropic glutamate receptors, transmitter output and fatty acids: studies in rat brain slices.
Topics: Acetophenones; Animals; Arachidonic Acid; Aspartic Acid; Corpus Striatum; Cyclohexanones; Cycloleucine; Cyclooxygenase Inhibitors; Fatty Acids; Glutamic Acid; In Vitro Techniques; Indomethacin; Lipoprotein Lipase; Male; Masoprocol; Membrane Potentials; Neurotoxins; Oleic Acids; Parietal Lobe; Phospholipases A; Phospholipases A2; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Serum Albumin; Stearic Acids | 1996 |
Pharmacological characterization of metabotropic glutamate receptors potentiating NMDA responses in mouse cortical wedge preparations.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Cycloleucine; Drug Synergism; Excitatory Amino Acid Agonists; In Vitro Techniques; Male; Mice; N-Methylaspartate; Neurotoxins; Receptors, Metabotropic Glutamate | 1996 |
Intraseptal administration of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid induces immediate early gene expression in lateral septal neurons.
Topics: Animals; Cycloleucine; Enzyme Inhibitors; Gene Expression; Genes, Immediate-Early; Injections; Lithium; Male; Masoprocol; Neurons; Phospholipases A; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Septum Pellucidum | 1996 |
Metabotropic glutamate receptor activation selectively limits excitotoxic damage in the intact neostriatum.
Topics: Analysis of Variance; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Kainic Acid; Male; Microinjections; N-Methylaspartate; Neostriatum; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1996 |
Stimulation of phospholipase C activity by norepinephrine, t-ACPD and bombesin in LA-N-2 cells.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alanine; Bombesin; Cycloleucine; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Humans; Inositol Phosphates; Isoproterenol; Isotope Labeling; Neuroblastoma; Neurokinin B; Neurotoxins; Norepinephrine; Propranolol; Receptors, Bombesin; Receptors, Metabotropic Glutamate; Tritium; Tumor Cells, Cultured; Type C Phospholipases | 1996 |
Modulation of excitatory synaptic transmission by low concentrations of glutamate in cultured rat hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic Acid; Benzothiadiazines; Calcium; Cells, Cultured; Cycloleucine; Evoked Potentials; Glutamic Acid; Hippocampus; Neurons; Patch-Clamp Techniques; Pertussis Toxin; Rats; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Virulence Factors, Bordetella; Wheat Germ Agglutinins | 1996 |
The enhancement and the inhibition of noradrenaline-induced cyclic AMP accumulation in rat brain by stimulation of metabotropic glutamate receptors.
Topics: Adrenergic Agonists; Animals; Brain Chemistry; Cerebral Cortex; Cyclic AMP; Cycloleucine; Excitatory Amino Acids; In Vitro Techniques; Neurotoxins; Norepinephrine; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stimulation, Chemical | 1996 |
Interaction between the intracellular Ca2+ stores in rat dissociated hippocampal neurones.
Topics: Animals; Caffeine; Calcium; Cholinergic Agonists; Cycloleucine; Hippocampus; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Neurons; Potassium Channels; Rats | 1996 |
Exposure of astrocytes to thrombin reduces levels of the metabotropic glutamate receptor mGluR5.
Topics: Animals; Astrocytes; Cells, Cultured; Cycloleucine; Down-Regulation; Glial Fibrillary Acidic Protein; Neurotoxins; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; RNA, Messenger; Thrombin; Transcription, Genetic; Transforming Growth Factor alpha | 1996 |
Cyclothiazide unmasks an AMPA-evoked release of arachidonic acid from cultured striatal neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Benzothiadiazines; Calcium; Cells, Cultured; Corpus Striatum; Cycloleucine; Drug Synergism; Embryo, Mammalian; Kinetics; Mice; Neurons; Neurotoxins | 1996 |
Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxicity in mice and glutamate toxicity in primary cultures of neurons.
Topics: Ammonia; Animals; Carnitine; Cells, Cultured; Choline; Cycloleucine; Glutamic Acid; Male; Methylamines; Mice; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1996 |
Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors.
Topics: Animals; Cells, Cultured; Cerebellum; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Glycine; Male; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1996 |
Metabotropic glutamate receptors potentiate responses to NMDA and AMPA from layer V cells in rat visual cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Drug Synergism; Excitatory Amino Acid Agonists; In Vitro Techniques; Iontophoresis; N-Methylaspartate; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Visual Cortex | 1996 |
Facilitation of long-term potentiation by prior activation of metabotropic glutamate receptors.
Topics: Animals; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synapses; Time Factors | 1996 |
The synergism between ACPD and arachidonic acid on glutamate release in hippocampus is age-dependent.
Topics: Aging; Animals; Arachidonic Acid; Cycloleucine; Drug Synergism; Excitatory Amino Acid Agonists; Glutamic Acid; Heparin; Hippocampus; Male; Rats; Rats, Wistar | 1996 |
Stimulatory effects of the putative metabotropic glutamate receptor antagonist L-AP3 on phosphoinositide turnover in neonatal rat cerebral cortex.
Topics: Alanine; Animals; Animals, Newborn; Cerebral Cortex; Cycloleucine; Excitatory Amino Acid Antagonists; Female; Hippocampus; In Vitro Techniques; Inositol Phosphates; Male; Mice; Neurotoxins; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stereoisomerism | 1996 |
Thyrotropin-releasing hormone (TRH) attenuates glutamate-stimulated increases in calcium in primary neuronal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Electrophysiology; Glutamic Acid; Intracellular Membranes; Ion Channel Gating; N-Methylaspartate; Neurons; Rats; Thyrotropin-Releasing Hormone | 1996 |
Metabotropic glutamate receptors switch visual response mode of lateral geniculate nucleus cells from burst to tonic.
Topics: Animals; Cats; Cycloleucine; Electric Stimulation; Electrophysiology; Evoked Potentials; Geniculate Bodies; Interneurons; Iontophoresis; Photic Stimulation; Receptors, AMPA; Receptors, Metabotropic Glutamate; Signal Transduction | 1996 |
Properties of a slow nonselective cation conductance modulated by neurotensin and other neurotransmitters in midbrain dopaminergic neurons.
Topics: Animals; Cations; Cations, Divalent; Cells, Cultured; Chelating Agents; Cyclic AMP; Cyclic GMP; Cycloleucine; Dopamine; Electrophysiology; Immunohistochemistry; Ion Channels; Male; Membrane Potentials; Mesencephalon; Neurokinin B; Neurons; Neurotensin; Neurotransmitter Agents; Rats | 1996 |
Metabotropic glutamate receptors coupled to IP3 production mediate inhibition of IAHP in rat dentate granule neurons.
Topics: Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Cycloleucine; Dentate Gyrus; GTP-Binding Proteins; Heparin; Inositol 1,4,5-Trisphosphate; Male; Neomycin; Neurons; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1996 |
Loss of mGluR-mediated hyperpolarizations and increase in mGluR depolarizations in basolateral amygdala neurons in kindling-induced epilepsy.
Topics: Amygdala; Animals; Cycloleucine; Electric Conductivity; Epilepsy; Evoked Potentials; In Vitro Techniques; Kindling, Neurologic; Male; Membrane Potentials; Neurons; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1996 |
Tyrosine kinase inhibitors enhance a Ca(2+)-activated K+ current (IAHP) and reduce IAHP suppression by a metabotropic glutamate receptor agonist in rat dentate granule neurones.
Topics: Adenylyl Cyclases; Animals; Calcium; Cycloleucine; Dentate Gyrus; Enzyme Activation; Enzyme Inhibitors; Genistein; In Vitro Techniques; Isoflavones; Male; Neuronal Plasticity; Neurons; Neurotoxins; Potassium Channels; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Staurosporine | 1996 |
Tachycardia after glutamate injection in rat spinal cord is not blocked by kynurenate or mimicked by metabotropic agonists.
Topics: Aminobutyrates; Analysis of Variance; Animals; Blood Pressure; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Injections, Spinal; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred WKY; Receptors, Metabotropic Glutamate; Spinal Cord; Tachycardia | 1996 |
cAMP levels increased by activation of metabotropic glutamate receptors correlate with visual plasticity.
Topics: Animal Husbandry; Animals; Cats; Cyclic AMP; Cycloleucine; Dark Adaptation; Functional Laterality; Neuronal Plasticity; Ocular Physiological Phenomena; Receptors, Metabotropic Glutamate; Visual Cortex; Visual Pathways | 1996 |
G-protein activation by metabotropic glutamate receptors reduces spike frequency adaptation in neocortical neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adult; Alanine; Amino Acids, Dicarboxylic; Animals; Benzoates; Cycloleucine; Enzyme Inhibitors; Frontal Lobe; Glycine; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Isoquinolines; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Protein Kinase Inhibitors; Protein Kinases; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction; Staurosporine; Sulfonamides; Thionucleotides | 1996 |
Potentiation of spontaneous acetylcholine release from motor nerve terminals by glutamate in Xenopus tadpoles.
Topics: Acetylcholine; Alanine; Animals; Calcium; Calcium Channel Blockers; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Larva; Motor Endplate; N-Methylaspartate; Neurotoxins; Quisqualic Acid; Second Messenger Systems; Verapamil; Xenopus laevis | 1996 |
Glutamate receptor subtypes mediate excitatory synaptic responses of rat lateral parabrachial neurons.
Topics: Animals; Cycloleucine; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Antagonists; Male; Neurons; Pons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1996 |
Stimulation of metabotropic glutamate receptors in the dorsomedial hypothalamus elevates heart rate in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cycloleucine; Dose-Response Relationship, Drug; Glycine; Heart Rate; Hypothalamus, Middle; Male; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Tachycardia | 1996 |
Anticonvulsant action of metabotropic glutamate receptor agonists in kindled amygdala of rats.
Topics: Aminobutyrates; Amygdala; Animals; Anticonvulsants; Cycloleucine; Electroencephalography; Excitatory Amino Acid Agonists; Injections; Kindling, Neurologic; Male; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1996 |
Differential effects of learning and recall of a spatial task on phosphoinositide hydrolysis induced by the metabotropic glutamate receptor agonist 1S,3R-ACPD (1S,3R-1-amino-cyclopentane-1,3-discarboxylic acid) in the hippocampus and the prefrontal cortex
Topics: Animals; Cycloleucine; Hippocampus; Hydrolysis; Lithium; Male; Maze Learning; Mental Recall; Phosphatidylinositols; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1996 |
Metabotropic glutamate receptor agonist-induced hyperpolarizations in rat basolateral amygdala neurons: receptor characterization and ion channels.
Topics: Amygdala; Animals; Cycloleucine; Dose-Response Relationship, Drug; Ion Channels; Male; Membrane Potentials; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1996 |
Metabotropic glutamate receptor dependent EPSP and EPSP-spike potentiation in area CA1 of the submerged rat hippocampal slice.
Topics: Animals; Cycloleucine; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Membrane Potentials; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1996 |
NMDA receptor dependence of mGlu-mediated depression of synaptic transmission in the CA1 region of the rat hippocampus.
Topics: Animals; Cycloleucine; Female; Hippocampus; In Vitro Techniques; Magnesium; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Synaptic Transmission | 1996 |
Excitatory amino acid regulation of astrocyte proteoglycans.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; CD57 Antigens; Cell Membrane; Cells, Cultured; Chondroitin Sulfates; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Heparitin Sulfate; Hippocampus; Immunohistochemistry; Kainic Acid; N-Methylaspartate; Protein Kinase C; Rats; Receptors, Metabotropic Glutamate; Subcellular Fractions; Sulfates; Sulfur Radioisotopes | 1996 |
Immortalized hypothalamic neurons express metabotropic glutamate receptors positively coupled to cyclic AMP formation.
Topics: Animals; Cell Division; Cell Line, Transformed; Colforsin; Cyclic AMP; Cycloleucine; Dinoprostone; Excitatory Amino Acid Agonists; Gonadotropin-Releasing Hormone; Hypothalamus; Mice; Neurons; Norepinephrine; Phosphatidylinositols; Quisqualic Acid; Receptors, Metabotropic Glutamate | 1996 |
Postsynaptic glutamate uptake in rat cerebellar Purkinje cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Benzoates; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ion Channel Gating; Kynurenic Acid; Membrane Potentials; Monosaccharide Transport Proteins; Neuroprotective Agents; Purkinje Cells; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrodotoxin | 1996 |
Comparison of nociceptive effects produced by intrathecal administration of mGluR agonists.
Topics: Animals; Behavior, Animal; Cycloleucine; Dose-Response Relationship, Drug; Injections, Spinal; Male; Neuroprotective Agents; Nociceptors; Rats | 1996 |
1S,3R-ACPD has cataleptogenic effects and reverses MK-801-, and less pronounced, D,L-amphetamine-induced locomotion.
Topics: Amphetamine; Animals; Catalepsy; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Locomotion; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reaction Time | 1996 |
Activation of pharmacologically distinct metabotropic glutamate receptors depresses reticulospinal-evoked monosynaptic EPSPs in the lamprey spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Axons; Benzoates; Cycloleucine; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Lampreys; Neural Pathways; Patch-Clamp Techniques; Receptors, Metabotropic Glutamate; Reticular Formation; Spinal Cord; Synaptic Transmission | 1996 |
The influence of nitric oxide on perigeniculate GABAergic cell activity in the anaesthetized cat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Cycloleucine; Enzyme Inhibitors; gamma-Aminobutyric Acid; Geniculate Bodies; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Penicillamine; Photic Stimulation; Quisqualic Acid; S-Nitroso-N-Acetylpenicillamine | 1996 |
Release of Ca2+ is the crucial step for the potentiation of IPSCs in the cultured cerebellar Purkinje cells of the rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Calcium Channels; Chelating Agents; Cycloleucine; Egtazic Acid; Enzyme Inhibitors; Estrenes; Evoked Potentials; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Heparin; Neuroprotective Agents; Phosphodiesterase Inhibitors; Purkinje Cells; Pyrrolidinones; Rats; Receptors, Metabotropic Glutamate; Ruthenium Red; Synapses; Thapsigargin; Type C Phospholipases | 1996 |
Pharmacological characterization of desensitization in a human mGlu1 alpha-expressing non-neuronal cell line co-transfected with a glutamate transporter.
Topics: Amino Acid Transport System X-AG; Animals; Carrier Proteins; Cell Line; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; Glycoproteins; Humans; Hydrolysis; Inosine Triphosphate; Inositol; Neurotoxins; Phosphatidylinositols; Rats; Receptors, Metabotropic Glutamate; Resorcinols | 1996 |
Feeding-evoked dopamine release in the nucleus, accumbens: regulation by glutamatergic mechanisms.
Topics: Animals; Cycloleucine; Dopamine; Excitatory Amino Acid Antagonists; Feeding Behavior; Glutamic Acid; Kynurenic Acid; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Ventral Tegmental Area | 1997 |
Metabotropic glutamate receptor activation modulates kainate and serotonin calcium response in astrocytes.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Astrocytes; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cerebral Cortex; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Nimodipine; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Second Messenger Systems; Serotonin; Suprachiasmatic Nucleus; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1997 |
Activation of metabotropic glutamate receptors increases endogenous protein kinase C substrate phosphorylation in adult hippocampal slices.
Topics: Animals; Autoradiography; Biotransformation; Cycloleucine; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Isoenzymes; Male; N-Methylaspartate; Neuroprotective Agents; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Subcellular Fractions; Tetradecanoylphorbol Acetate | 1997 |
An electrophysiological study of neurons in the horizontal limb of the diagonal band of Broca.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Frontal Lobe; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetrodotoxin | 1997 |
Characterization of metabotropic glutamate receptor-mediated nitric oxide production in vivo.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Biomarkers; Calcium Channels; Citrulline; Cycloleucine; Dantrolene; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Male; Microdialysis; Muscle Proteins; N-Methylaspartate; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Ryanodine Receptor Calcium Release Channel; Tetrodotoxin | 1997 |
Effects of glutamate receptor agonists and antagonists on Ca2+ uptake in rat hippocampal slices lesioned by glucose deprivation or by kainate.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glucose; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Organ Culture Techniques; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Synaptic Transmission | 1997 |
A metabotropic glutamate receptor agonist regulates neurotrophin messenger RNA in rat forebrain.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cycloleucine; In Situ Hybridization; Injections, Intraventricular; Male; Nerve Growth Factors; Neurotrophin 3; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; RNA, Messenger | 1996 |
Excitatory amino acid receptors coupled to the phosphoinositide pathway in Bergmann glia.
Topics: Animals; Astrocytes; Calcium Channels; Cells, Cultured; Cerebellum; Chick Embryo; Cycloleucine; Glutamic Acid; Hydrolysis; Neuroglia; Phosphatidylinositols; Quisqualic Acid; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Stimulation, Chemical | 1997 |
Activation of hamster suprachiasmatic neurons in vitro via metabotropic glutamate receptors.
Topics: Animals; Cricetinae; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Extracellular Space; In Vitro Techniques; Male; Mesocricetus; N-Methylaspartate; Neurons; Receptors, Metabotropic Glutamate; Suprachiasmatic Nucleus | 1996 |
Conformational analysis of glutamic acid analogues as probes of glutamate receptors using molecular modelling and NMR methods. Comparison with specific agonists.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Probes; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Xenopus | 1997 |
Presynaptic modulation by metabotropic glutamate receptors of excitatory and inhibitory synaptic inputs to hypothalamic magnocellular neurons.
Topics: Animals; Cycloleucine; Electric Stimulation; Hypothalamus; Immunohistochemistry; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1997 |
Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Brain; Calcium; Cell Line; Chromosome Mapping; Chromosomes, Human, Pair 6; Cloning, Molecular; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Genetic Variation; Glutamic Acid; Humans; Membrane Potentials; Molecular Sequence Data; Oocytes; Open Reading Frames; Rats; Receptors, AMPA; Recombinant Proteins; RNA, Messenger; Sequence Deletion; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Transcription, Genetic; Transfection; Xenopus | 1996 |
The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors.
Topics: Aging; Animals; Animals, Newborn; Brain; Cloning, Molecular; Colforsin; Cyclic AMP; Cycloleucine; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Humans; Inositol; Kinetics; Neuroprotective Agents; Phosphatidylinositols; Proline; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Resorcinols; Second Messenger Systems | 1996 |
Dual action of metabotropic glutamate receptor agonists on neuronal excitability and synaptic transmission in spinal ventral horn neurons in vitro.
Topics: Amino Acids, Dicarboxylic; Animals; Anterior Horn Cells; Benzoates; Cycloleucine; Dose-Response Relationship, Drug; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Rats; Spinal Cord; Synaptic Transmission; Time Factors | 1996 |
Modulation of plateau properties in dorsal horn neurones in a slice preparation of the turtle spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Neurokinin A; Neurons, Afferent; Neuroprotective Agents; Neurotoxins; Peptide Fragments; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, Neurokinin-1; Spinal Cord; Substance P; Tetrodotoxin; Turtles | 1997 |
Block of HFS-induced LTP in the dentate gyrus by 1S,3S-ACPD: further evidence against LTP as a model for learning.
Topics: Animals; Cycloleucine; Dentate Gyrus; Learning; Long-Term Potentiation; Male; Models, Neurological; Neuroprotective Agents; Rats; Rats, Wistar | 1997 |
Decrease in [Ca2+]c but not in cAMP Mediates L-AP4 inhibition of glutamate release: PKC-mediated suppression of this inhibitory pathway.
Topics: Aminobutyrates; Animals; Calcium; Cerebral Cortex; Cyclic AMP; Cycloleucine; Cytoplasm; Excitatory Amino Acid Antagonists; Osmolar Concentration; Protein Kinase C; Rats; Rats, Wistar | 1996 |
Pressor and sympathetic responses to excitatory amino acids are not augmented in the ventrolateral medulla of Dahl salt-sensitive rats.
Topics: Analysis of Variance; Animals; Blood Pressure; Body Weight; Cycloleucine; Diet, Sodium-Restricted; Excitatory Amino Acid Agonists; Glutamic Acid; Heart Rate; Male; Medulla Oblongata; Microinjections; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Inbred Strains; Sodium, Dietary; Splanchnic Circulation; Sympathetic Nervous System | 1997 |
Activation of group-II metabotropic glutamate receptors blocks induction of long-term potentiation and depotentiation in area CA1 of the rat in vivo.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Long-Term Potentiation; Male; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1997 |
The effect of metabotropic excitatory amino-acid receptor agonists and antagonists on hypothalamic neurons which respond to changes in scrotal skin temperature in the anesthetized male rat.
Topics: Action Potentials; Alanine; Animals; Cycloleucine; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Hot Temperature; Hypothalamus, Anterior; Male; Neurons; Preoptic Area; Rats; Scrotum; Thermoreceptors | 1997 |
Differential regulation of neuronal proteoglycans by activation of excitatory amino acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Chondroitin Sulfate Proteoglycans; Cycloleucine; DNA Primers; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Glycosylphosphatidylinositols; Glypicans; Heparan Sulfate Proteoglycans; Hippocampus; Lectins, C-Type; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurocan; Neurons; Neuroprotective Agents; Polymerase Chain Reaction; Proteoglycans; Rats; Receptors, Glutamate; RNA, Messenger; Transcription, Genetic | 1997 |
HFS-induced long-term potentiation and LFS-induced depotentiation in area CA1 of the hippocampus are not good models for learning.
Topics: Animals; Cycloleucine; Discrimination, Psychological; Electric Stimulation; Electrophysiology; Evoked Potentials; Hippocampus; Injections, Intraventricular; Learning; Long-Term Potentiation; Male; Maze Learning; Models, Psychological; Neuronal Plasticity; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Space Perception; Visual Perception | 1997 |
Evidence for functional metabotropic glutamate receptors in the dorsal cochlear nucleus.
Topics: Animals; Cochlear Nucleus; Cycloleucine; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Linear Models; Neurons; Patch-Clamp Techniques; Pyramidal Cells; Receptors, AMPA; Receptors, Metabotropic Glutamate; Second Messenger Systems; Synaptic Transmission | 1997 |
Role of metabotropic glutamate receptors in the cat's visual cortex during development.
Topics: Animals; Animals, Newborn; Cats; Cyclic AMP; Cycloleucine; In Vitro Techniques; Receptors, Metabotropic Glutamate; Second Messenger Systems; Visual Cortex | 1996 |
1S, 3R-ACPD induces a region of negative slope conductance in the steady-state current-voltage relationship of hippocampal pyramidal cells.
Topics: Animals; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Kinetics; Membrane Potentials; N-Methylaspartate; Neural Conduction; Patch-Clamp Techniques; Potassium Channels; Pyramidal Cells; Rats; Receptors, Metabotropic Glutamate | 1997 |
Regulation of excitatory input to inhibitory interneurons of the dentate gyrus during hypoxia.
Topics: Animals; Benzoates; Cycloleucine; Dentate Gyrus; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Antagonists; Glycine; Hypoxia, Brain; In Vitro Techniques; Interneurons; Kinetics; Male; Membrane Potentials; Patch-Clamp Techniques; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Synaptic Transmission | 1997 |
Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Animals, Newborn; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamates; Glycine; N-Methylaspartate; Rats; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Spinal Cord | 1996 |
Mechanisms of 1S,3R-ACPD-induced neuroprotection in rat hippocampal slices subjected to oxygen and glucose deprivation.
Topics: Animals; Cyclic AMP; Cycloleucine; Dose-Response Relationship, Drug; Electrophysiology; Glucose; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Microscopy, Confocal; Neuroprotective Agents; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 1996 |
The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception.
Topics: Aminobutyrates; Analysis of Variance; Animals; Benzoates; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; Glycine; Male; Pain; Rats; Receptors, Metabotropic Glutamate; Resorcinols | 1996 |
Methamphetamine-induced sensitization of dopamine release via a metabotropic glutamate receptor mediated pathway in rat striatal slices.
Topics: Analysis of Variance; Animals; Benzoates; Corpus Striatum; Cycloleucine; Dopamine; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Injections, Intraperitoneal; Male; Methamphetamine; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stereoisomerism | 1997 |
Metabotropic glutamate receptor-mediated inhibition and excitation of substantia nigra dopamine neurons.
Topics: Animals; Cycloleucine; Dopamine; Dose-Response Relationship, Drug; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Substantia Nigra | 1997 |
Enhancement of NMDA responses by group I metabotropic glutamate receptor activation in striatal neurones.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agents; Glycine; Male; N-Methylaspartate; Neostriatum; Neurons; Patch-Clamp Techniques; Protein Kinase C; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols | 1997 |
Metabotropic glutamate receptor subtypes mediating slow inward tail current (IADP) induction and inhibition of synaptic transmission in olfactory cortical neurones.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Guinea Pigs; Male; Muscarinic Agonists; Neurons; Olfactory Pathways; Oxotremorine; Patch-Clamp Techniques; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1997 |
Regulation of cerebral microvessels by glutamatergic mechanisms.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Cerebrovascular Circulation; Cycloleucine; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Microcirculation; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synapses; Vasoconstriction; Vasodilation | 1997 |
Involvement of metabotropic glutamate receptors in Gi- and Gs-dependent modulation of adenylate cyclase activity induced by a novel cognition enhancer NS-105 in rat brain.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic alpha-Agonists; Alanine; Animals; Baclofen; Brimonidine Tartrate; Cell Membrane; Cerebral Cortex; Cholera Toxin; Cognition; Colforsin; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Isoproterenol; Kinetics; Male; Manganese; Pertussis Toxin; Piperidines; Proline; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Neurotransmitter; Virulence Factors, Bordetella; Yohimbine | 1997 |
Synchronous 20 Hz rhythmic activity in hippocampal networks induced by activation of metabotropic glutamate receptors in vitro.
Topics: Animals; Bicuculline; Carbachol; Cholinergic Agonists; Cycloleucine; Electroencephalography; Excitatory Amino Acid Agonists; GABA Antagonists; Hippocampus; In Vitro Techniques; Nerve Net; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate | 1997 |
The t-ACPD-induced current response in rat cerebellum.
Topics: Aging; Animals; Cerebellum; Cycloleucine; Evoked Potentials; Gene Expression Regulation, Developmental; GTP-Binding Proteins; In Vitro Techniques; Neuroprotective Agents; Rats; Receptors, Metabotropic Glutamate; Synapses | 1993 |
Differential responsiveness of metabotropic glutamate receptors coupled to phosphoinositide hydrolysis to agonists in various brain areas of the adult rat.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Cycloleucine; Dose-Response Relationship, Drug; Hippocampus; Hydrolysis; Ibotenic Acid; In Vitro Techniques; Kinetics; Male; Neuroprotective Agents; Organ Specificity; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1996 |
G-protein-mediated desensitization of metabotropic glutamatergic and muscarinic responses in CA3 cells in rat hippocampus.
Topics: Animals; Cations; Cyclic AMP-Dependent Protein Kinases; Cycloleucine; Electrophysiology; Glutamic Acid; GTP-Binding Proteins; Hippocampus; Methacholine Chloride; Muscarinic Agonists; Neurons; Neuroprotective Agents; Organ Culture Techniques; Protein Kinase C; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Sensitivity and Specificity | 1997 |
Metabotropic glutamate agonist-induced rotation: a pharmacological, FOS immunohistochemical, and [14C]-2-deoxyglucose autoradiographic study.
Topics: Animals; Autoradiography; Basal Ganglia; Behavior, Animal; Caffeine; Carbon Radioisotopes; Cycloleucine; Deoxyglucose; Dopamine; Dopamine Agonists; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Glucose; Glycine; Immunohistochemistry; Male; Neuroprotective Agents; Proto-Oncogene Proteins c-fos; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Receptors, Purinergic P1; Resorcinols; Rotation; Salicylamides; Thalamic Nuclei; Xanthines | 1997 |
Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist.
Topics: Adenylyl Cyclases; Animals; Aspartic Acid; Behavior, Animal; Brain; Cell Line; Colforsin; Cricetinae; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; Hydrolysis; In Vitro Techniques; Indans; Injections, Intraventricular; Male; Mice; Phosphatidylinositols; Phospholipase D; Rats; Receptors, Metabotropic Glutamate; Transfection; Type C Phospholipases | 1997 |
Microinfusion of the metabotropic glutamate receptor agonist 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid into the nucleus accumbens induces dopamine-dependent locomotor activation in the rat.
Topics: Analysis of Variance; Animals; Brain Mapping; Cycloleucine; Dopamine; Infusions, Parenteral; Male; Motor Activity; Neuroprotective Agents; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Time Factors | 1997 |
Characterization of metabotropic glutamate receptors in rat C6 glioma cells.
Topics: Animals; Brain Neoplasms; Cell Membrane; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glioma; Glutamic Acid; Guanylyl Imidodiphosphate; Kinetics; Neuroprotective Agents; Radioligand Assay; Rats; Receptors, Metabotropic Glutamate; Tumor Cells, Cultured | 1997 |
Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP.
Topics: Animals; Behavior, Animal; Binding, Competitive; Central Nervous System; Conditioning, Psychological; Cycloleucine; Fear; Hippocampus; Learning Disabilities; Long-Term Potentiation; Maze Learning; Mice; Mice, Inbred Strains; Mutation; Receptors, Metabotropic Glutamate; Reference Values; Synapses | 1997 |
Neuroprotective sigma ligands attenuate NMDA and trans-ACPD-induced calcium signaling in rat primary neurons.
Topics: Animals; Calcium; Cells, Cultured; Cycloleucine; Ligands; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, sigma; Signal Transduction | 1997 |
Prolonged anticonvulsant action of glutamate metabotropic receptor agonists in inferior colliculus of genetically epilepsy-prone rats.
Topics: Animals; Behavior, Animal; Cycloleucine; Dose-Response Relationship, Drug; Epilepsy; Female; Glycine; Inferior Colliculi; Male; Neuroprotective Agents; Noise; Phosphoserine; Rats; Receptors, Metabotropic Glutamate | 1997 |
Metabotropic glutamate receptor mGluR5 in astrocytes: pharmacological properties and agonist regulation.
Topics: Animals; Astrocytes; Calcium; Cells, Cultured; Concanavalin A; Cyclic AMP; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hydrolysis; Inositol Phosphates; Neuroprotective Agents; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sensitivity and Specificity; Tritium | 1997 |
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells.
Topics: Animals; Calcium; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cycloleucine; Dipeptides; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Histamine H1 Antagonists; Humans; Hydrolysis; Kidney; Neuropeptides; Neuroprotective Agents; Phosphates; Rats; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Transfection | 1997 |
Amyloid beta protein (25-35) stimulation of phospholipase C in LA-N-2 cells.
Topics: Adrenergic Agonists; Adrenergic alpha-Agonists; Amyloid beta-Peptides; Bombesin; Calcium; Chelating Agents; Cholera Toxin; Cycloleucine; Egtazic Acid; Enzyme Inhibitors; Epinephrine; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Humans; Neuroblastoma; Neuroprotective Agents; Norepinephrine; Peptide Fragments; Pertussis Toxin; Protein Kinase Inhibitors; Protein Kinases; Sensitivity and Specificity; Thionucleotides; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1997 |
A long-lasting calcium-activated nonselective cationic current is generated by synaptic stimulation or exogenous activation of group I metabotropic glutamate receptors in CA1 pyramidal neurons.
Topics: Animals; Calcium; Cations; Cycloleucine; Ion Transport; Male; Neuroprotective Agents; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission; Time Factors | 1997 |
N-methyl-D-aspartic acid-induced penile erection and yawning: role of hypothalamic paraventricular nitric oxide.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hemoglobins; Male; Methylene Blue; Microdialysis; N-Methylaspartate; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxytocin; Paraventricular Hypothalamic Nucleus; Penile Erection; Rats; Rats, Sprague-Dawley; Yawning | 1997 |
Two pathways of nitric oxide production through glutamate receptors in the rat cerebellum in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine; Calcium; Cerebellum; Cycloleucine; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Male; N-Methylaspartate; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Rats, Wistar; Receptors, Glutamate | 1997 |
Metabotropic glutamate receptor mediated long-term depression in developing hippocampus.
Topics: Animals; Benzoates; Cycloleucine; Depression, Chemical; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; Neuronal Plasticity; Neuroprotective Agents; Nitrendipine; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission; Theophylline | 1997 |
Activation of group III metabotropic glutamate receptors depresses glutamatergic transmission at corticostriatal synapse.
Topics: Aminobutyrates; Animals; Benzoates; Corpus Striatum; Cycloleucine; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Male; Neural Inhibition; Neuroprotective Agents; Phosphoserine; Presynaptic Terminals; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1997 |
Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain.
Topics: Amyloid beta-Protein Precursor; Benzoates; Cell Line; Cycloleucine; Enzyme Activation; Excitatory Amino Acid Antagonists; Gene Expression; Glutamic Acid; Glycine; GTP-Binding Proteins; Humans; Melitten; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Protein Kinases; Quisqualic Acid; Receptors, Metabotropic Glutamate; Transfection; Type C Phospholipases | 1997 |
Glutamate-dependent activation of NF-kappaB during mouse cerebellum development.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; Animals; Antibody Specificity; Cell Nucleus; Cerebellum; Cycloleucine; Cytoplasm; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Developmental; Glutamic Acid; Injections, Intraperitoneal; Mice; Mice, Transgenic; N-Methylaspartate; Neuroprotective Agents; Neurotransmitter Agents; NF-kappa B; Transgenes | 1997 |
Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist.
Topics: Animals; Benzoates; Caudate Nucleus; Corpus Striatum; Cyclic AMP; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1997 |
Role of group I metabotropic glutamate receptors in the patterning of epileptiform activities in vitro.
Topics: Animals; Cycloleucine; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Techniques; Picrotoxin; Receptors, Metabotropic Glutamate | 1997 |
Changes in extracellular nitrite and nitrate levels after inhibition of glial metabolism with fluorocitrate.
Topics: Aconitate Hydratase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Benzoates; Cerebellum; Citrates; Citric Acid Cycle; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glycine; Male; N-Methylaspartate; Neuroglia; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Nitroarginine; Quinoxalines; Rats; Rats, Wistar; Substrate Specificity | 1997 |
Influences of excitatory amino acid receptor agonists on nucleus of the solitary tract neurons receiving aortic depressor nerve inputs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aorta; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Nervous System Physiological Phenomena; Neurons; Rats; Rats, Sprague-Dawley; Solitary Nucleus | 1997 |
A novel cognition enhancer NS-105 modulates adenylate cyclase activity through metabotropic glutamate receptors in primary neuronal culture.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cells, Cultured; Cerebral Cortex; Cognition; Colforsin; Cyclic AMP; Cycloleucine; Mice; Neurons; Pertussis Toxin; Piperidines; Proline; Receptors, Metabotropic Glutamate; Virulence Factors, Bordetella | 1997 |
Neurotensin and dopamine D2 activation oppositely regulate the same K+ conductance in rat midbrain dopaminergic neurons.
Topics: Animals; Cells, Cultured; Cycloleucine; Dopamine; Dopamine Agonists; Neurons; Neuroprotective Agents; Neurotensin; Patch-Clamp Techniques; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine D2; Ventral Tegmental Area | 1997 |
Influence of metabotropic glutamate receptor agonists on the inhibitory effects of adenosine A1 receptor activation in the rat hippocampus.
Topics: Adenosine; Animals; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Protein Kinase C; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Resorcinols | 1997 |
Modulation of excitatory synaptic transmission in locus coeruleus by multiple presynaptic metabotropic glutamate receptors.
Topics: Aminobutyrates; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acids; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Neurotoxins; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission | 1997 |
Down-regulation of mGluR5 by antisense deoxynucleotides alters pharmacological responses to applications of ACPD in the rat hippocampus.
Topics: Animals; Cycloleucine; DNA, Antisense; Down-Regulation; Electrophysiology; Hippocampus; Immunoblotting; Male; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1997 |
Potentiation of NMDA and AMPA responses by group I mGluR in spinal cord motoneurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Drug Synergism; Excitatory Amino Acid Agonists; Glycine; In Vitro Techniques; Male; Membrane Potentials; Motor Neurons; N-Methylaspartate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord | 1997 |
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors.
Topics: Animals; CHO Cells; Cricetinae; Cycloleucine; Glutamic Acid; In Vitro Techniques; Receptors, Metabotropic Glutamate; Second Messenger Systems; Stereoisomerism; Structure-Activity Relationship | 1997 |
Block of theta-burst-induced long-term potentiation by (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid: further evidence against long-term potentiation as a model for learning.
Topics: Action Potentials; Animals; Cycloleucine; Electric Stimulation; Excitatory Postsynaptic Potentials; Learning; Long-Term Potentiation; Male; Neuronal Plasticity; Neuroprotective Agents; Periodicity; Rats; Rats, Wistar; Spatial Behavior; Synaptic Transmission | 1997 |
Ontogeny of non-NMDA glutamate receptors in rat barrel field cortex: I. Metabotropic receptors.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Cycloleucine; Gene Expression Regulation, Developmental; Glutamic Acid; Immunohistochemistry; Neuroprotective Agents; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Somatosensory Cortex; Tritium; Vibrissae | 1997 |
Phospholipase C isozymes selectively couple to specific neurotransmitter receptors.
Topics: Animals; Ataxia; Binding Sites; Brain; Carbachol; Cerebellum; Cycloleucine; Epilepsy; Hippocampus; Isoenzymes; Mice; Mice, Knockout; Muscarinic Agonists; Mutagenesis; Phosphatidylinositols; Phospholipase C beta; Piperazines; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Serotonin Receptor Agonists; Signal Transduction; Type C Phospholipases | 1997 |
Modulation of mEPSCs in olfactory bulb mitral cells by metabotropic glutamate receptors.
Topics: Adenylyl Cyclases; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Axons; Cadmium; Calcium Channels; Cells, Cultured; Cycloleucine; Electric Stimulation; Excitatory Amino Acid Agonists; Membrane Potentials; Neurons; Neuroprotective Agents; Olfactory Bulb; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrodotoxin | 1997 |
The metabotropic glutamate receptor mGluR5 induces calcium oscillations in cultured astrocytes via protein kinase C phosphorylation.
Topics: Animals; Astrocytes; Calcium; Cells, Cultured; Cycloleucine; Growth Substances; Intracellular Membranes; Osmolar Concentration; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Up-Regulation | 1997 |
Strategies for receptor control of neurotransmitter release.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium Channels; Cycloleucine; Elapid Venoms; Exocytosis; Glutamic Acid; Homeostasis; Models, Neurological; Neuroprotective Agents; Neurotoxins; Potassium Channels; Potassium Chloride; Protein Kinase C; Rats; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Synaptosomes | 1998 |
The influence of 1S,3R-ACPD on central dopaminergic transmission and recognition memory.
Topics: Animals; Avoidance Learning; Catalepsy; Cognition; Cycloleucine; Dopamine; Male; Memory; Motor Activity; Neuroprotective Agents; Rats; Rats, Wistar; Stereotyped Behavior; Synaptic Transmission | 1996 |
Metabotropic glutamate receptor activation modulates epileptiform activity in the hippocampus.
Topics: 4-Aminopyridine; Adrenergic Antagonists; Animals; Bicuculline; Cholinergic Antagonists; Cycloleucine; Electrophysiology; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Neurotransmitter Agents; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1997 |
Role of metabotropic glutamate receptors in the depression of GABA-mediated depolarization of frog primary afferent terminals.
Topics: Animals; Cycloleucine; Electric Stimulation; Electrophysiology; gamma-Aminobutyric Acid; In Vitro Techniques; Isomerism; Membrane Potentials; Nerve Endings; Neurons, Afferent; Neuroprotective Agents; Rana pipiens; Receptors, Metabotropic Glutamate; Signal Transduction; Spinal Cord; Spinal Nerve Roots | 1997 |
Presynaptic depression at a calyx synapse: the small contribution of metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Afferent Pathways; Aminobutyrates; Animals; Brain Stem; Cycloleucine; Electric Stimulation; Glutamic Acid; Glycine; Neuronal Plasticity; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses | 1997 |
Metabotropic glutamate receptor agonists evoke calcium waves in isolated Müller cells.
Topics: Adenosine Triphosphate; Ambystoma; Aminobutyrates; Animals; Calcium Channels; Cycloleucine; Excitatory Amino Acid Agonists; Fluorescent Dyes; Histocytochemistry; In Vitro Techniques; Neuroglia; Neuroprotective Agents; Quisqualic Acid; Receptors, Metabotropic Glutamate; Retina | 1997 |
Is activation of the metabotropic glutamate receptors impaired in the hippocampal CA1 area of the aged rat?
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Benzoates; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neuronal Plasticity; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses | 1997 |
Metabotropic glutamate autoreceptors on nerve terminals of crayfish muscle depress or facilitate release.
Topics: Animals; Astacoidea; Cycloleucine; Glutamic Acid; Membrane Potentials; Nerve Endings; Neuromuscular Junction; Receptors, Metabotropic Glutamate | 1997 |
4-Methylhomoibotenic acid activates a novel metabotropic glutamate receptor coupled to phosphoinositide hydrolysis.
Topics: Animals; Cell Line; Cricetinae; Cycloleucine; Female; Hydrolysis; Ibotenic Acid; Phosphatidylinositols; Rats; Receptors, Metabotropic Glutamate; Xenopus | 1997 |
Activation of metabotropic glutamate receptors in the rat nucleus accumbens increases locomotor activity in a dopamine-dependent manner.
Topics: Animals; Cycloleucine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Microinjections; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1997 |
Metabotropic glutamate receptor enhancement of spontaneous IPSCs in neocortical interneurons.
Topics: Action Potentials; Animals; Cell Polarity; Chlorides; Cycloleucine; Evoked Potentials; Frontal Lobe; In Vitro Techniques; Interneurons; Neocortex; Patch-Clamp Techniques; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrodotoxin | 1997 |
Excitation of rat subthalamic nucleus neurones in vitro by activation of a group I metabotropic glutamate receptor.
Topics: Adenine Nucleotides; Affinity Labels; Animals; Benzoates; Cycloleucine; Cyclopropanes; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Male; Neurons; Neuroprotective Agents; Pyridoxal; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Thalamic Nuclei | 1997 |
Metabotropic glutamate receptors modulate synaptic transmission in the perforant path: pharmacology and localization of two distinct receptors.
Topics: Aminobutyrates; Animals; Cycloleucine; Dentate Gyrus; Excitatory Postsynaptic Potentials; Male; Neuronal Plasticity; Perforant Pathway; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1997 |
Development of metabotropic glutamate receptor-mediated synaptic inhibition.
Topics: Animals; Benzoates; Cycloleucine; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Male; Neural Inhibition; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1997 |
Characterization of the inward current induced by metabotropic glutamate receptor stimulation in rat ventromedial hypothalamic neurones.
Topics: Animals; Cell Membrane; Cycloleucine; Electric Stimulation; Electrophysiology; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Photolysis; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sodium; Type C Phospholipases; Ventromedial Hypothalamic Nucleus | 1997 |
Metabotropic glutamate receptors regulate N-methyl-D-aspartate-mediated synaptic transmission in nucleus accumbens.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Male; Membrane Potentials; Nucleus Accumbens; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1997 |
Glutamate metabotropic receptor agonist 1S,3R-ACPD induces internucleosomal DNA fragmentation and cell death in rat striatum.
Topics: Alanine; Animals; Autoradiography; Cell Death; Cycloleucine; DNA Fragmentation; Electrophoresis, Agar Gel; Excitatory Amino Acid Antagonists; Histocytochemistry; In Situ Hybridization; Neurotoxins; Nucleosomes; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1997 |
Acute ethanol alters calcium signals elicited by glutamate receptor agonists and K+ depolarization in cultured cerebellar Purkinje neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebellar Cortex; Cycloleucine; Embryo, Mammalian; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Membrane Potentials; Potassium; Purkinje Cells; Rats; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Resorcinols | 1997 |
Effects of the metabotropic glutamate receptor antagonist MCPG on phosphoinositide turnover and synaptic plasticity in visual cortex.
Topics: Action Potentials; Age Factors; Animals; Benzoates; Binding, Competitive; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Long-Term Potentiation; Neuronal Plasticity; Neuroprotective Agents; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Metabotropic Glutamate; Synapses; Visual Cortex | 1998 |
(R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) fails to block long-term potentiation under urethane anaesthesia in vivo.
Topics: Analysis of Variance; Anesthesia; Anesthetics, Intravenous; Animals; Benzoates; Body Temperature; Brain; Cycloleucine; Drug Synergism; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Male; Neuroprotective Agents; Rats; Receptors, Metabotropic Glutamate; Tetanus; Time Factors; Urethane | 1997 |
Transmitter regulation of plateau properties in turtle motoneurons.
Topics: Animals; Atropine; Baclofen; Benzoates; Calcium Channels; Calcium Channels, L-Type; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Membrane Potentials; Motor Neurons; Muscarine; Nifedipine; Patch-Clamp Techniques; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord; Tetraethylammonium; Tetrodotoxin; Turtles | 1998 |
Abnormal synaptic transmission in the olfactory bulb of Fyn-kinase-deficient mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Crosses, Genetic; Cycloleucine; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Heterozygote; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Neurons; Neuroprotective Agents; Olfactory Bulb; Picrotoxin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, Glutamate; Synaptic Transmission | 1998 |
Impairment of brain kynurenic acid production by glutamate metabotropic receptor agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Cycloleucine; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Sodium | 1997 |
Behavioral activity of 1S,3R-ACPD, an agonist of metabotropic glutamate receptors.
Topics: Animals; Apomorphine; Avoidance Learning; Catalepsy; Cycloleucine; Haloperidol; Injections, Intraventricular; Male; Memory; Motor Activity; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stereotyped Behavior | 1997 |
Action of a metabotropic glutamate receptor agonist in rat lateral septum: induction of a sodium-dependent inward aftercurrent.
Topics: Age Factors; Animals; Animals, Newborn; Cycloleucine; Electric Conductivity; Gluconates; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Membrane Potentials; Neuroprotective Agents; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Septal Nuclei; Sodium; Sodium Channels; Tetrodotoxin | 1997 |
Prostaglandins stimulate calcium-dependent glutamate release in astrocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Biological Transport; Calcium; Cells, Cultured; Cerebral Cortex; Cycloleucine; Glutamic Acid; Hippocampus; In Vitro Techniques; Prostaglandins; Rats; Receptors, AMPA; Receptors, Glutamate; Visual Cortex | 1998 |
Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord.
Topics: Alanine; Animals; Antihypertensive Agents; Behavior, Animal; Benzothiadiazines; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Glycine; Male; Mustard Plant; Neuroprotective Agents; Nociceptors; Pain; Phenylacetates; Plant Extracts; Plant Oils; Plants, Medicinal; Rats; Rats, Inbred Strains; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord | 1997 |
Evidence for neuronal origin and metabotropic receptor-mediated regulation of extracellular glutamate and aspartate in rat striatum in vivo following electrical stimulation of the prefrontal cortex.
Topics: Animals; Aspartic Acid; Benzoates; Calcium; Corpus Striatum; Cycloleucine; Dicarboxylic Acids; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Glycine; Male; Neurons; Neurotransmitter Uptake Inhibitors; Prefrontal Cortex; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tetrodotoxin; Time Factors | 1998 |
Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzoates; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Kinetics; Motor Neurons; N-Methylaspartate; Neuroprotective Agents; Rats; Spinal Cord | 1997 |
Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes.
Topics: Animals; Cells, Cultured; Cycloleucine; Excitatory Amino Acid Agonists; Liver; Neuroprotective Agents; Phosphatidylinositol Phosphates; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate | 1997 |
In vivo microdialysis reveals facilitatory metabotropic glutamate receptors regulating excitatory amino acid release in rat nucleus tractus solitarius.
Topics: Animals; Aspartic Acid; Benzoates; Calcium; Chromatography, High Pressure Liquid; Cycloleucine; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Glycine; Kinetics; Male; Microdialysis; Neurotoxins; Rats; Rats, Inbred WKY; Receptors, Metabotropic Glutamate; Solitary Nucleus; Tetrodotoxin | 1998 |
The involvement of metabotropic glutamate receptors in sensory transmission in dorsal horn of the rat spinal cord.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agonists; Extracellular Space; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord; Synaptic Transmission | 1998 |
Characterization of an intracellular alkaline shift in rat astrocytes triggered by metabotropic glutamate receptors.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4-Chloro-7-nitrobenzofurazan; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Animals, Newborn; Anti-Bacterial Agents; Astrocytes; Benzoates; Caffeine; Calcium; Cells, Cultured; Chlorides; Cycloleucine; Dicyclohexylcarbodiimide; Enzyme Inhibitors; Glycine; HEPES; Hydrogen-Ion Concentration; Indans; Intracellular Fluid; Ion Transport; Ionomycin; Ionophores; Macrolides; Nigericin; Rats; Receptors, Metabotropic Glutamate; Sodium | 1998 |
Modulation of spindle oscillations by acetylcholine, cholecystokinin and 1S,3R-ACPD in the ferret lateral geniculate and perigeniculate nuclei in vitro.
Topics: Acetylcholine; Animals; Cerebral Cortex; Cholecystokinin; Cycloleucine; Electrophysiology; Extracellular Space; Female; Ferrets; gamma-Aminobutyric Acid; Geniculate Bodies; In Vitro Techniques; Male; Neurons; Neuroprotective Agents; Potassium Channels; Receptors, Metabotropic Glutamate; Thalamus | 1997 |
Guanine nucleotides inhibit cAMP accumulation induced by metabotropic glutamate receptor activation.
Topics: Animals; Cyclic AMP; Cycloleucine; Glutamic Acid; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Monophosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hippocampus; Neurotoxins; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Thionucleotides | 1998 |
Target-specific expression of presynaptic mossy fiber plasticity.
Topics: Afferent Pathways; Animals; Colforsin; Cyclic AMP; Cycloleucine; Cyclopropanes; Electric Stimulation; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Long-Term Potentiation; Mossy Fibers, Hippocampal; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1998 |
Seizures and neuronal damage induced in the rat by activation of group I metabotropic glutamate receptors with their selective agonist 3,5-dihydroxyphenylglycine.
Topics: Analysis of Variance; Animals; Cerebral Ventricles; Cycloleucine; Excitatory Amino Acid Agonists; Glycine; Infusions, Parenteral; Male; Motor Activity; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Seizures | 1998 |
Regulation of striatal dopamine release by metabotropic glutamate receptors.
Topics: Animals; Consciousness; Corpus Striatum; Cycloleucine; Dopamine; Male; Microdialysis; Neuroprotective Agents; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tetrodotoxin | 1998 |
Differential involvement of metabotropic and p75 neurotrophin receptors in effects of nerve growth factor and neurotrophin-3 on cultured Purkinje cell survival.
Topics: Animals; Cell Survival; Cycloleucine; Enzyme Inhibitors; Glycine; Nerve Growth Factors; Neuroprotective Agents; Neurotrophin 3; Protein Kinase C; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Receptors, Metabotropic Glutamate; Receptors, Nerve Growth Factor; Signal Transduction | 1998 |
Local activation of metabotropic glutamate receptors inhibits the handling-induced increased release of dopamine in the nucleus accumbens but not that of dopamine or noradrenaline in the prefrontal cortex: comparison with inhibition of ionotropic receptor
Topics: 3,4-Dihydroxyphenylacetic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Cycloleucine; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; GABA Agonists; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Microdialysis; Neuroprotective Agents; Norepinephrine; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, GABA-B; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Stress, Physiological | 1998 |
(+)-MCPG blocks induction of LTP in CA1 of rat hippocampus via agonist action at an mGluR group II receptor.
Topics: Amino Acids, Dicarboxylic; Animals; Benzoates; Cycloleucine; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Neuroprotective Agents; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1998 |
Modulation of GAP-43 mRNA by GABA and glutamate in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Blotting, Northern; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; gamma-Aminobutyric Acid; GAP-43 Protein; Gene Expression Regulation, Developmental; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunohistochemistry; In Situ Hybridization; Microtubule-Associated Proteins; Muscimol; N-Methylaspartate; Neurons; Neuroprotective Agents; Piperazines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1998 |
Metabotropic glutamate receptors depress glutamate-mediated synaptic input to rat midbrain dopamine neurones in vitro.
Topics: Alanine; Animals; Benzoates; Cycloleucine; Dopamine; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamates; Glycine; In Vitro Techniques; Male; Mesencephalon; Neurons; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1998 |
Analysis of the interaction between arachidonic acid and metabotropic glutamate receptor activation reveals that phospholipase C acts as a coincidence detector in the expression of long-term potentiation in the rat dentate gyrus.
Topics: Animals; Arachidonic Acid; Cycloleucine; Dentate Gyrus; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Genistein; In Vitro Techniques; Long-Term Potentiation; Male; Neomycin; Neuroprotective Agents; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Type C Phospholipases | 1998 |
Group II and III metabotropic glutamate receptors modulate paired pulse depression in the rat dentate gyrus in vitro.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Benzoates; Cycloleucine; Cyclopropanes; Dentate Gyrus; Evoked Potentials, Somatosensory; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Neuroprotective Agents; Rats; Receptors, Metabotropic Glutamate; Resorcinols | 1997 |
Opposing regulation of tau protein levels by ionotropic and metabotropic glutamate receptors in human NT2 neurons.
Topics: Cell Death; Cell Line; Cycloleucine; Excitatory Amino Acid Agonists; Gene Expression; Humans; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; tau Proteins | 1998 |
Evidence that functional glutamate receptors are not expressed on rat or human cerebromicrovascular endothelial cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Calcium; Capillaries; Cattle; Cells, Cultured; Cerebrovascular Circulation; Colforsin; Cyclic AMP; Cycloleucine; Endothelin-1; Endothelium, Vascular; Gene Expression; Humans; Inositol 1,4,5-Trisphosphate; Kainic Acid; Mice; N-Methylaspartate; Neurons; Polymerase Chain Reaction; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Second Messenger Systems | 1998 |
Aminobicyclo[2.2.1.]heptane dicarboxylic acids (ABHD), rigid analogs of ACPD and glutamic acid: synthesis and pharmacological activity on metabotropic receptors mGluR1 and mGluR2.
Topics: Chromatography, High Pressure Liquid; Cycloleucine; Dicarboxylic Acids; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Isomerism; Models, Chemical; Molecular Conformation; Norbornanes; Receptors, Metabotropic Glutamate | 1998 |
Metabotropic glutamate receptor agonist increases neuropeptide mRNA expression in rat striatum.
Topics: Animals; Corpus Striatum; Cycloleucine; Dynorphins; Enkephalins; Globus Pallidus; In Situ Hybridization; Male; Microinjections; Neurons; Neuropeptides; Protein Precursors; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; RNA, Messenger; Substance P; Substantia Nigra | 1998 |
Enhanced visual responses in cat dLGN--potentiation by priming with excitatory amino acids.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Cycloleucine; Drug Synergism; Excitatory Amino Acids; Geniculate Bodies; Iontophoresis; N-Methylaspartate; Neurons; Neuroprotective Agents; Photic Stimulation; Visual Perception | 1998 |
Prenatal ethanol exposure enhances glutamate release stimulated by quisqualate in rat cerebellar granule cell cultures.
Topics: Alcoholism; Amino Acids; Animals; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Ethanol; Female; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Potassium Chloride; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1998 |
Metabotropic glutamate receptors limit adenylyl cyclase-mediated effects in rat hippocampus via protein kinase C.
Topics: Adenylyl Cyclases; Animals; Bucladesine; Cycloleucine; Hippocampus; Isoproterenol; Male; Models, Neurological; Neurons; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Metabotropic Glutamate; Second Messenger Systems | 1998 |
Priming of long-term potentiation induced by activation of metabotropic glutamate receptors coupled to phospholipase C.
Topics: Animals; Cycloleucine; Electric Stimulation; Estrenes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Neuroprotective Agents; Pyramidal Cells; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Synapses; Type C Phospholipases | 1998 |
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.
Topics: Animals; Bridged Bicyclo Compounds; Calcium; Cells, Cultured; Cerebellum; CHO Cells; Cricetinae; Cyclic AMP; Cycloleucine; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Glutamic Acid; Inositol Phosphates; Kidney; Ligands; Models, Molecular; Molecular Conformation; Norbornanes; Rats; Receptors, Metabotropic Glutamate; Stereoisomerism | 1998 |
Regulation of the nigrostriatal pathway by metabotropic glutamate receptors during development.
Topics: Alanine; Animals; Cerebral Cortex; Corpus Striatum; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Microscopy, Confocal; Nerve Fibers; Neural Pathways; Neurons; Neuroprotective Agents; Organ Culture Techniques; Phytohemagglutinins; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Second Messenger Systems; Substantia Nigra; Tyrosine 3-Monooxygenase | 1998 |
mGluR activation reveals a tonic NMDA component in inflammatory hyperalgesia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hyperalgesia; Inflammation; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1998 |
Intracellular free calcium dynamics in stretch-injured astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Calcium; Cells, Cultured; Cerebral Cortex; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Inositol Phosphates; Intracellular Fluid; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Thapsigargin | 1998 |
Metabotropic glutamate receptor agonists potentiate cyclic AMP formation induced by forskolin or beta-adrenergic receptor activation in cerebral cortical astrocytes in culture.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Colforsin; Cyclic AMP; Cycloleucine; Drug Synergism; Estrenes; Excitatory Amino Acid Agonists; Glycine; Neocortex; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Adrenergic, beta; Receptors, Metabotropic Glutamate; Resorcinols; Signal Transduction; Type C Phospholipases; Up-Regulation | 1998 |
How many subtypes of inhibitory cells in the hippocampus?
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Axons; Cell Size; Cycloleucine; Dendrites; Excitatory Amino Acid Antagonists; Hippocampus; Interneurons; Muscarine; Muscarinic Agonists; Neural Inhibition; Neuroprotective Agents; Neurotransmitter Agents; Norepinephrine; Rats; Receptors, Metabotropic Glutamate; Serotonin; Sympathomimetics; Tetrodotoxin | 1998 |
Metabotropic glutamate receptor-mediated control of neurotransmitter release.
Topics: 4-Aminopyridine; Animals; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Lampreys; Membrane Potentials; Motor Neurons; Neuroprotective Agents; Neurotransmitter Agents; Potassium; Presynaptic Terminals; Receptors, Metabotropic Glutamate; Resorcinols; Ryanodine; Spinal Cord; Synaptic Transmission | 1998 |
Effect of glutamate receptor agonists on catecholamine secretion in bovine chromaffin cells.
Topics: Adrenal Medulla; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nicotine; Receptors, Glutamate | 1998 |
Regulation of immediate early gene c-fos and zif/268 mRNA expression in rat striatum by metabotropic glutamate receptor.
Topics: Animals; Benzazepines; Benzoates; Corpus Striatum; Cycloleucine; DNA-Binding Proteins; Dopamine Antagonists; Dose-Response Relationship, Drug; Early Growth Response Protein 1; Excitatory Amino Acid Antagonists; Gene Expression; Genes, Immediate-Early; Glycine; Immediate-Early Proteins; In Situ Hybridization; Male; Microinjections; Neuroprotective Agents; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Metabotropic Glutamate; RNA, Messenger; Transcription Factors; Zinc Fingers | 1998 |
Evidence for metabotropic glutamate receptor activation in the induction of depolarization-induced suppression of inhibition in hippocampal CA1.
Topics: 4-Aminopyridine; Amino Acids, Dicarboxylic; Animals; Benzoates; Calcium Channels; Cycloleucine; Cyclopropanes; Enzyme Inhibitors; Ethylmaleimide; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Male; Membrane Potentials; Neural Inhibition; Neuroprotective Agents; Patch-Clamp Techniques; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Signal Transduction; Synapses | 1998 |
Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonist S-2-methyl-4-carboxy-phenylglycine.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Male; N-Methylaspartate; Naphthols; Neurons, Afferent; Neuroprotective Agents; Propylene Glycols; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Thalamus | 1998 |
Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurones.
Topics: Animals; Carrageenan; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; Inflammation; Male; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord; Supine Position | 1998 |
Presynaptic mGlu1 type receptors potentiate transmitter output in the rat cortex.
Topics: Animals; Benzoates; Bridged Bicyclo Compounds; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Indans; Microdialysis; Parietal Lobe; Rats; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Resorcinols | 1998 |
Sensitivity and density of glutamate receptor subtypes in the hippocampal formation are altered in pentylenetetrazole-kindled rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Chemistry; Convulsants; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Inositol Phosphates; Kindling, Neurologic; Male; Neuroprotective Agents; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tritium | 1998 |
Progression of change in NMDA, non-NMDA, and metabotropic glutamate receptor function at the developing corticothalamic synapse.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn; Benzoates; Cerebral Cortex; Cycloleucine; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Mice; Mice, Inbred ICR; Nerve Fibers; Neurons; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Thalamus | 1998 |
Metabotropic glutamate receptor activation modulates sound level processing in the cochlear nucleus.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Auditory Pathways; Auditory Perception; Benzoates; Cats; Cochlear Nucleus; Cycloleucine; Evoked Potentials; Excitatory Amino Acid Antagonists; Gerbillinae; Glycine; N-Methylaspartate; Neurons; Neuroprotective Agents; Receptors, Metabotropic Glutamate; Time Factors | 1998 |
Metabotropic and ionotropic glutamate receptors regulate calcium channel currents in salamander retinal ganglion cells.
Topics: Ambystoma; Aminobutyrates; Animals; Barium; Calcium Channels; Chelating Agents; Cycloleucine; Egtazic Acid; Excitatory Amino Acid Agonists; In Vitro Techniques; Kainic Acid; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Retinal Ganglion Cells; Signal Transduction | 1998 |
Glutamate-stimulated neuropeptide Y mRNA expression in the rat dentate gyrus: a prominent role of metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Injections; Injections, Intraperitoneal; Male; N-Methylaspartate; Neuropeptide Y; Neuropeptides; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; RNA, Messenger | 1998 |
The group III metabotropic glutamate receptor agonist, l-AP4, reduces EPSPs in some layers of rat visual cortex.
Topics: Alanine; Aminobutyrates; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; N-Methylaspartate; Neuroprotective Agents; Presynaptic Terminals; Rats; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Visual Cortex | 1998 |
Antidepressant treatment influences group I of glutamate metabotropic receptors in slices from hippocampal CA1 region.
Topics: Action Potentials; Animals; Antidepressive Agents, Tricyclic; Cycloleucine; Electroshock; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Imipramine; Inositol Phosphates; Male; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols | 1998 |
The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats.
Topics: Amphetamine; Animals; Benzoates; Central Nervous System Stimulants; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Injections, Intraventricular; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1998 |
A modulatory effect of extracellular Ca2+ on type 1alpha metabotropic glutamate receptor-mediated signalling.
Topics: Animals; Arecoline; Calcium; Cell Line; Cricetinae; Cycloleucine; Enzyme Activation; Excitatory Amino Acid Agonists; Inositol Phosphates; Kidney; Methacholine Chloride; Muscarinic Agonists; Quisqualic Acid; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Type C Phospholipases | 1998 |
Metabotropic glutamate receptor-mediated excitation and inhibition of sympathetic preganglionic neurones.
Topics: Amino Acids, Dicarboxylic; Animals; Autonomic Fibers, Preganglionic; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord | 1998 |
Phosphorylation of mitogen-activated protein kinase in cultured rat cortical glia by stimulation of metabotropic glutamate receptors.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebral Cortex; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flavonoids; Glycine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Neuroglia; Neuroprotective Agents; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Tyrosine | 1998 |
Changes in GluR4 expression induced by metabotropic receptor activation in radial glia cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Chick Embryo; Cycloleucine; Glutamic Acid; Kainic Acid; Kinetics; N-Methylaspartate; Neuroglia; Polymerase Chain Reaction; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Metabotropic Glutamate; Retina; RNA, Messenger; Transcription, Genetic; Up-Regulation | 1998 |
Metabotropic glutamate receptor activation in vivo induces intraneuronal amyloid immunoreactivity in guinea pig hippocampus.
Topics: Amyloid; Amyloid beta-Protein Precursor; Animals; Cycloleucine; Guinea Pigs; Hippocampus; Immunohistochemistry; Male; Microinjections; Neurons; Receptors, Metabotropic Glutamate | 1998 |
Activation of group I metabotropic glutamate receptors elicits pH changes in cultured rat cortical glia and neurons.
Topics: Animals; Animals, Newborn; Astrocytes; Calcium; Cells, Cultured; Cerebral Cortex; Chelating Agents; Cycloleucine; Egtazic Acid; Enzyme Inhibitors; Glycine; Hydrogen-Ion Concentration; Neuroglia; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1998 |
Glutamate locally activates dendritic outputs of thalamic interneurons.
Topics: Animals; Cats; Cycloleucine; Dendrites; Geniculate Bodies; Glutamic Acid; In Vitro Techniques; Interneurons; Neural Inhibition; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Tetrodotoxin; Thalamus | 1998 |
Characterization of neuroprotection from excitotoxicity by moderate and profound hypothermia in cultured cortical neurons unmasks a temperature-insensitive component of glutamate neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Cold Temperature; Cycloleucine; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Fluorescent Dyes; Glutamic Acid; Humans; Hypothermia, Induced; Kainic Acid; Mice; N-Methylaspartate; Neuroglia; Neurons; Neurotoxins; Synapses | 1998 |
Activation of group I mGluRs increases spontaneous IPSC frequency in rat frontal cortex.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Frontal Lobe; Glycine; Neural Inhibition; Neuroprotective Agents; Patch-Clamp Techniques; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Synaptic Transmission; Tetrodotoxin | 1998 |
Low-affinity kainate receptors and long-lasting depression of NMDA-receptor-mediated currents in rat superficial dorsal horn.
Topics: Action Potentials; Animals; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Glutamic Acid; Indoles; Ion Channel Gating; Kainic Acid; Male; N-Methylaspartate; Neurons, Afferent; Neuroprotective Agents; Oximes; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission | 1998 |
Glutamate receptors underlying excitatory synaptic transmission in the rat's lateral superior olive studied in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Aminobutyrates; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Neuroprotective Agents; Olivary Nucleus; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1998 |
Effects of metabotropic glutamate receptor block on the synaptic transmission and plasticity in the rat medial vestibular nuclei.
Topics: Animals; Benzoates; Cycloleucine; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Long-Term Potentiation; Neuronal Plasticity; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Vestibular Nuclei | 1998 |
Stimulation of Na+-K+-2Cl- cotransporter in neuronal cells by excitatory neurotransmitter glutamate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Bumetanide; Carrier Proteins; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agents; Gene Expression Regulation; Glutamic Acid; Humans; Kinetics; N-Methylaspartate; Neuroblastoma; Neurons; Potassium; Receptors, Glutamate; Sodium-Potassium-Chloride Symporters; Tumor Cells, Cultured | 1998 |
Blockade of GABA(B) receptors facilitates muscarinic agonist-induced epileptiform activity in immature rat piriform cortex in vitro.
Topics: Animals; Benzylamines; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; GABA-B Receptor Antagonists; Male; Membrane Potentials; Muscarinic Agonists; Neurons; Neuroprotective Agents; Oxotremorine; Phosphinic Acids; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Synaptic Transmission | 1998 |
Neurotransmitter activation of inwardly rectifying potassium current in dissociated hippocampal CA3 neurons: interactions among multiple receptors.
Topics: 2-Chloroadenosine; Animals; Baclofen; Barium; Cells, Cultured; Cycloleucine; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; GABA Agonists; Hippocampus; Membrane Potentials; Neuroprotective Agents; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyramidal Cells; Rats; Rats, Long-Evans; Receptors, GABA-B; Receptors, Metabotropic Glutamate; Serotonin; Somatostatin | 1998 |
Contrasting Ca2+ channel subtypes at cell bodies and synaptic terminals of rat anterioventral cochlear bushy neurones.
Topics: Algorithms; Animals; Calcium Channels; Cell Separation; Cochlea; Cycloleucine; Electric Stimulation; Electrophysiology; In Vitro Techniques; Membrane Potentials; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Presynaptic Terminals; Rats | 1998 |
Glutamate-induced swelling of cultured astrocytes is mediated by metabotropic glutamate receptor.
Topics: Animals; Astrocytes; Cell Size; Cells, Cultured; Cerebral Cortex; Cycloleucine; Dantrolene; Glutamates; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1996 |
Functional coupling of human metabotropic glutamate receptor hmGlu1d: comparison to splice variants hmGlu1a and -1b.
Topics: Adenylate Cyclase Toxin; Aequorin; Alternative Splicing; Amino Acid Sequence; Animals; Calcium; Cell Line; CHO Cells; Cricetinae; Cycloleucine; Excitatory Amino Acid Agonists; Genetic Variation; Glutamic Acid; Humans; Inositol Phosphates; Molecular Sequence Data; Pertussis Toxin; Polymerase Chain Reaction; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Transfection; Virulence Factors, Bordetella | 1998 |
Phospholipase C-independent group I metabotropic glutamate receptor-mediated inward current in mouse purkinje cells.
Topics: Animals; Calcium; Calcium Channels; Cycloleucine; Egtazic Acid; Electric Conductivity; Evoked Potentials; Heparin; Image Processing, Computer-Assisted; Inositol 1,4,5-Trisphosphate Receptors; Mice; Patch-Clamp Techniques; Purkinje Cells; Receptors, Cytoplasmic and Nuclear; Receptors, Metabotropic Glutamate; Signal Transduction; Sodium-Calcium Exchanger; Synapses; Thiourea; Type C Phospholipases | 1998 |
Priming of long-term potentiation by prior activation of group I and II metabotropic glutamate receptors in the rat dentate gyrus in vitro.
Topics: Amino Acids, Dicarboxylic; Animals; Cycloleucine; Dentate Gyrus; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Long-Term Potentiation; Membrane Potentials; Neuroprotective Agents; Phenylacetates; Propionates; Rats; Receptors, Metabotropic Glutamate | 1998 |
Regulation of intrinsic and synaptic properties of neonatal rat trigeminal motoneurons by metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzoates; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neuroprotective Agents; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrodotoxin; Trigeminal Nuclei | 1998 |
The effect of ACPD on the responses to NMDA and AMPA varies with layer in slices of rat visual cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Drug Synergism; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Visual Cortex | 1998 |
Depletion of dopamine in the nucleus accumbens prevents the generation of locomotion by metabotropic glutamate receptor activation.
Topics: Amphetamine; Animals; Cycloleucine; Dopamine; Locomotion; Male; Microinjections; Nucleus Accumbens; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1998 |
Receptor-activated Ca2+ increases in vibrodissociated cortical astrocytes: a nonenzymatic method for acute isolation of astrocytes.
Topics: Animals; Astrocytes; Calcium; Cell Separation; Cell Size; Cells, Cultured; Cerebral Cortex; Cycloleucine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glutamic Acid; Immunohistochemistry; Indans; Norepinephrine; Phenylephrine; Potassium; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Serotonin | 1998 |
Kindled seizures increase metabotropic glutamate receptor expression and function in the rat supraoptic nucleus.
Topics: Amygdala; Animals; Calcium; Cerebral Cortex; Cycloleucine; Disease Models, Animal; Epilepsy; Immunohistochemistry; In Situ Hybridization; Kindling, Neurologic; Magnesium; Male; Neurons; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Seizures; Supraoptic Nucleus | 1998 |
Carnitine inhibits hydrolysis of inositol phospholipids induced by activation of metabotropic receptors.
Topics: Animals; Carbachol; Carnitine; Catechols; Cycloleucine; Glycine; GTP-Binding Proteins; Hippocampus; Hydrolysis; Male; Neuroprotective Agents; Norepinephrine; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Type C Phospholipases | 1998 |
Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures.
Topics: Animals; Cesium; Choline; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Feedback; Glutamic Acid; Hippocampus; Kainic Acid; Ketamine; Magnesium; Neural Inhibition; Neurons; Neuroprotective Agents; Nitrous Oxide; Nootropic Agents; Propionates; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1998 |
Endogenous activation of metabotropic glutamate receptors contributes to burst frequency regulation in the lamprey locomotor network.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Lampreys; Locomotion; Membrane Potentials; N-Methylaspartate; Nerve Net; Periodicity; Propionates; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord; Synaptic Transmission | 1998 |
Group I mGluRs modulate calcium currents in rat GP: functional implications.
Topics: Animals; Benzoates; Calcium Channel Blockers; Calcium Channels; Cycloleucine; Electric Conductivity; Excitatory Amino Acid Antagonists; Globus Pallidus; Glycine; Male; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols | 1998 |
Metabotropic glutamate receptor agonist (1S,3R-ACPD) increased frontal cortex dopamine release in aged but not in young rats.
Topics: Animals; Benzoates; Cycloleucine; Dopamine; Excitatory Amino Acid Antagonists; Frontal Lobe; Glycine; Male; Microdialysis; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Time Factors | 1998 |
The metabotropic glutamate receptors of the vestibular organs.
Topics: Afferent Pathways; Animals; Auditory Pathways; Cycloleucine; Excitatory Amino Acid Antagonists; Feedback; Hair Cells, Auditory; In Vitro Techniques; Models, Biological; Rana pipiens; Receptors, Metabotropic Glutamate; RNA; Semicircular Canals; Vestibule, Labyrinth | 1998 |
Role of group I metabotropic glutamate receptors in traumatic spinal cord white matter injury.
Topics: Age Factors; Animals; Astrocytes; Benzoates; Cycloleucine; Electrophysiology; Estrenes; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Glycine; Immunohistochemistry; Male; Membrane Potentials; Nerve Fibers; Neuroprotective Agents; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord; Spinal Cord Injuries; Type C Phospholipases | 1998 |
Conformational changes of the smooth endoplasmic reticulum are facilitated by L-glutamate and its receptors in rat Purkinje cells.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apnea; Bradycardia; Calcium Signaling; Cycloleucine; Dendrites; Endoplasmic Reticulum, Smooth; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia, Brain; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Neuroprotective Agents; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Respiration | 1998 |
Chronic morphine treatment selectively augments metabotropic glutamate receptor-induced inhibition of N-methyl-D-aspartate receptor-mediated neurotransmission in nucleus accumbens.
Topics: Analgesics, Opioid; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Morphine; Neuroprotective Agents; Nucleus Accumbens; Propionates; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Nociceptive integration in the rat spinal cord: role of non-linear membrane properties of deep dorsal horn neurons.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cell Membrane; Cycloleucine; Electric Stimulation; Electrophysiology; Female; Male; Models, Neurological; Neurons, Afferent; Neuroprotective Agents; Nociceptors; Nonlinear Dynamics; Pain; Rats; Rats, Wistar; Spinal Cord | 1998 |
Inhibition by inorganic ions of a sustained calcium signal evoked by activation of mGlu5 receptors in rat cortical neurons and glia.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Cations; Cells, Cultured; Cerebral Cortex; Cycloleucine; Neuroglia; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1998 |
Expression of a foreign G-protein coupled receptor modulates the excitability of the peptidergic bag cell neurons of Aplysia.
Topics: Action Potentials; Animals; Aplysia; Cells, Cultured; Cycloleucine; Electric Stimulation; GTP-Binding Proteins; Neurons; Receptors, Metabotropic Glutamate | 1998 |
The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity.
Topics: Aging; Amino Acids; Animals; Binding, Competitive; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Humans; In Vitro Techniques; Long-Term Potentiation; Neuronal Plasticity; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Resorcinols; Transfection; Xanthenes | 1998 |
Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice.
Topics: Animals; Cerebral Ventricles; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; Indans; Infusions, Parenteral; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Reaction Time; Resorcinols; Seizures | 1998 |
Characterisation of mGluRs which modulate nociception in the PAG of the mouse.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Mice; Microinjections; Neuroprotective Agents; Pain; Periaqueductal Gray; Receptors, Metabotropic Glutamate; Time Factors | 1998 |
Membrane potential and intracellular Ca2+ oscillations activated by mGluRs in hippocampal stratum oriens/alveus interneurons.
Topics: Animals; Benzoates; Calcium; Calcium Signaling; Cycloleucine; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Image Processing, Computer-Assisted; In Vitro Techniques; Interneurons; Male; Membrane Potentials; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tetrodotoxin | 1999 |
LTP occludes the interaction between arachidonic acid and ACPD and NGF and ACPD.
Topics: Animals; Arachidonic Acid; Calcium; Cycloleucine; Dentate Gyrus; Drug Interactions; Electric Stimulation; Glutamic Acid; Hippocampus; Long-Term Potentiation; Male; Nerve Growth Factors; Perforant Pathway; Potassium Chloride; Rats; Rats, Wistar; Synaptosomes | 1998 |
Metabotropic glutamate receptor agonists reduce glutamate release from cultured astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Culture Media, Conditioned; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sodium-Potassium-Exchanging ATPase | 1999 |
(1S,3R)-ACPD, a metabotropic glutamate receptor agonist, enhances damage after global ischaemia.
Topics: Animals; Benzoates; Brain Ischemia; Cell Count; Cell Survival; Cycloleucine; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Gerbillinae; Glycine; Hippocampus; Male; Neurons; Neuroprotective Agents; Receptors, Metabotropic Glutamate | 1999 |
Local glutamatergic and GABAergic synaptic circuits and metabotropic glutamate receptors in the hypothalamic paraventricular and supraoptic nuclei.
Topics: Animals; Cycloleucine; Electric Stimulation; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Models, Neurological; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Supraoptic Nucleus; Synapses | 1998 |
Mechanisms involved in the metabotropic glutamate receptor-enhancement of NMDA-mediated motoneurone responses in frog spinal cord.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Benzoates; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Chlorpromazine; Cycloleucine; Dose-Response Relationship, Drug; Drug Synergism; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; GTP-Binding Proteins; In Vitro Techniques; Kynurenic Acid; Magnesium; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neuroprotective Agents; Pertussis Toxin; Rana pipiens; Receptors, Metabotropic Glutamate; Reflex; Resorcinols; Second Messenger Systems; Spinal Cord; Sulfonamides; Tetrodotoxin; Thapsigargin; Virulence Factors, Bordetella | 1999 |
mGluR7-like metabotropic glutamate receptors inhibit NMDA-mediated excitotoxicity in cultured mouse cerebellar granule neurons.
Topics: Animals; Calcium Channels; Cell Death; Cells, Cultured; Cerebellum; Cyclic GMP; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Mice; Microtubule-Associated Proteins; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Patch-Clamp Techniques; Phosphoserine; Propionates; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Phosphoinositide hydrolysis in vivo with group I metabotropic glutamate receptor agonists.
Topics: Amino Acids; Animals; Brain Chemistry; Cerebellum; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Hydrolysis; Injections, Intraventricular; Male; Neuroprotective Agents; Phenylacetates; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Tritium; Type C Phospholipases; Xanthenes | 1999 |
Differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 after excitotoxicity in a rat model of Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Cycloleucine; Excitatory Amino Acid Agonists; Huntington Disease; Kainic Acid; Male; Neostriatum; Nerve Growth Factors; Neuroprotective Agents; Neurotrophin 3; Quinolinic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1998 |
The effects of excitatory amino acids on isolated gut segments of the rat.
Topics: Animals; Aspartic Acid; Cycloleucine; Digestive System; Digestive System Physiological Phenomena; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Female; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; N-Methylaspartate; Neuroprotective Agents; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Cardiovascular responses to microinjections of excitatory amino acids into the area postrema of the rat.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Intravenous; Animals; Blood Pressure; Bradycardia; Cerebral Ventricles; Cycloleucine; Decerebrate State; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Male; Microinjections; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Wistar; Tachycardia; Urethane | 1999 |
Intracerebral administration of metabotropic glutamate receptor agonists disrupts prepulse inhibition of acoustic startle in Sprague-Dawley rats.
Topics: Acoustic Stimulation; Amino Acids, Dicarboxylic; Animals; Cycloleucine; Dopamine; Excitatory Amino Acid Agonists; Glutamine; Inhibition, Psychological; Male; Neuroprotective Agents; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reflex, Startle; Visual Cortex | 1999 |
Evidence that a novel metabotropic glutamate receptor mediates the induction of long-term potentiation at CA1 synapses in the hippocampus.
Topics: Animals; Benzoates; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Rats; Receptors, Metabotropic Glutamate; Resorcinols; Synapses | 1999 |
Group I metabotropic glutamate receptors mediate phospholipase D stimulation in rat cultured astrocytes.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Astrocytes; Benzoates; Carcinogens; Cerebellum; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Enzyme Activation; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Neurons; Neuroprotective Agents; Norepinephrine; Phospholipase D; Phosphorus Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sympathomimetics; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1999 |
Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia.
Topics: Animals; Astrocytes; Benzoates; Brain; Brain Chemistry; Calcium; Cells, Cultured; Cycloleucine; DNA Primers; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gene Expression; Glutamic Acid; Glycine; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Microglia; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 1999 |
Reduced function of L-AP4-sensitive metabotropic glutamate receptors in human epileptic sclerotic hippocampus.
Topics: Action Potentials; Adult; Aminobutyrates; Cycloleucine; Dentate Gyrus; Electrophysiology; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Humans; Neuroprotective Agents; Perforant Pathway; Propionates; Receptors, Metabotropic Glutamate; Sclerosis; Synaptic Transmission | 1999 |
Effects of varying the expression level of recombinant human mGlu1alpha receptors on the pharmacological properties of agonists and antagonists.
Topics: Animals; CHO Cells; Cricetinae; Cycloleucine; Humans; Immunohistochemistry; Inositol Phosphates; Isopropyl Thiogalactoside; Pyruvic Acid; Quisqualic Acid; Receptors, Metabotropic Glutamate; Recombinant Proteins | 1999 |
Glutamate regulates IP3-type and CICR stores in the avian cochlear nucleus.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alanine; Animals; Benzoates; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Chelating Agents; Chick Embryo; Cochlear Nucleus; Cyclic AMP; Cycloleucine; Cysteine; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Gallic Acid; Glutamic Acid; Glycine; Ibotenic Acid; Inositol 1,4,5-Trisphosphate Receptors; Ion Channel Gating; Neurons; Neuroprotective Agents; Neurotransmitter Agents; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Receptors, Cytoplasmic and Nuclear; Ryanodine; Second Messenger Systems; Thionucleotides | 1999 |
Group I mGlu receptor modulation of dopamine release in the rat striatum in vivo.
Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cycloleucine; Dopamine; Drug Interactions; Electrochemistry; Female; Microdialysis; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Visual Cortex | 1999 |
Group I and II metabotropic glutamate receptor expression in cultured rat spinal cord astrocytes.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Astrocytes; Calcium; Cells, Cultured; Cycloleucine; Excitatory Amino Acid Antagonists; Fura-2; Gene Expression Regulation; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Spinal Cord | 1999 |
Design and models for estimating antagonist potency (pA2, Kd and IC50) following the detection of antagonism observed in the presence of intrinsic activity.
Topics: Amino Acids, Dicarboxylic; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; Gene Library; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Humans; Kinetics; Models, Neurological; Models, Statistical; Neuroprotective Agents; Organization and Administration; Receptors, Metabotropic Glutamate; Recombinant Proteins; Sulfur Radioisotopes; Transfection | 1999 |
Pharmacological characterization of an unusual mGluR-evoked neuronal hyperpolarization mediated by activation of GIRK channels.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; G Protein-Coupled Inwardly-Rectifying Potassium Channels; In Vitro Techniques; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, GABA-B; Receptors, Metabotropic Glutamate; Songbirds; Vocalization, Animal | 1999 |
ACPD-mediated slow-onset potentiation is associated with cell death in the rat CA1 region in vivo.
Topics: Animals; Benzoates; Cell Death; Cell Survival; Cycloleucine; Evoked Potentials; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; Male; Neuronal Plasticity; Neuroprotective Agents; Rats; Rats, Wistar | 1999 |
Cardiovascular response to group I metabotropic glutamate receptor activation in NTS.
Topics: Animals; Baroreflex; Benzoates; Blood Pressure; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Kynurenic Acid; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sympathetic Nervous System | 1999 |
Activation of NMDA receptors protects against glutamate neurotoxicity in the retina: evidence for the involvement of neurotrophins.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Growth Factors; Neuroprotective Agents; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptors, N-Methyl-D-Aspartate; Receptors, Nerve Growth Factor; Retina | 1999 |
Differential effects of metabotropic glutamate receptor antagonists on bursting activity in the amygdala.
Topics: Amygdala; Animals; Benzoates; Cycloleucine; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Kindling, Neurologic; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Synapses | 1999 |
Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino-cyclopentyl-1,3- dicarboxylate impacts on long-term potentiation in the dentate gyrus in the rat: analysis of age-related changes.
Topics: Aging; Animals; Arachidonic Acid; Cycloleucine; Dentate Gyrus; Drug Synergism; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glutamic Acid; Long-Term Potentiation; Male; Mitogen-Activated Protein Kinase 1; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1999 |
Group I mGluR activation causes voltage-dependent and -independent Ca2+ rises in hippocampal pyramidal cells.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Cycloleucine; Guinea Pigs; Hippocampus; In Vitro Techniques; Ion Channel Gating; Membrane Potentials; Methoxyhydroxyphenylglycol; Patch-Clamp Techniques; Pyramidal Cells; Receptors, Metabotropic Glutamate | 1999 |
Gating of BDNF-induced synaptic potentiation by cAMP.
Topics: Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cells, Cultured; Cyclic AMP; Cycloleucine; Excitatory Postsynaptic Potentials; Indoles; Nerve Growth Factors; Neuronal Plasticity; Neurons; Neurotrophin 3; Okadaic Acid; Patch-Clamp Techniques; Pyrroles; Signal Transduction; Synapses; Synaptic Transmission; Thionucleotides; Xenopus | 1999 |
Metabotropic glutamate receptor modulation of excitotoxicity in the neostriatum: role of calcium channels.
Topics: Animals; Barium; Brain Edema; Cadmium; Calcium Channel Blockers; Calcium Channels; Cycloleucine; Excitatory Amino Acid Agonists; Glycine; Membrane Potentials; Methoxyhydroxyphenylglycol; Microscopy, Video; N-Methylaspartate; Neostriatum; Neuroprotective Agents; Neurotoxins; omega-Conotoxin GVIA; Organ Culture Techniques; Patch-Clamp Techniques; Peptides; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1999 |
Metabotropic glutamate receptor agonists protect from oxygen-glucose deprivation- and colchicine-induced apoptosis in primary cultures of cerebellar granule cells.
Topics: Animals; Apoptosis; Cell Hypoxia; Cells, Cultured; Cerebellum; Colchicine; Cycloleucine; Cyclopropanes; Glucose; Glycine; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1999 |
Glutamate-triggered events inducing corticostriatal long-term depression.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Cycloleucine; Electric Stimulation; Electrophysiology; Glutamic Acid; Hydroxylamine; In Vitro Techniques; Male; Membrane Potentials; Neuronal Plasticity; Neurons; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Sulpiride; Synaptic Transmission; Time Factors | 1999 |
(2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties.
Topics: Animals; Cycloleucine; Cyclopropanes; Glycerophospholipids; Glycine; Hippocampus; In Vitro Techniques; Phospholipase D; Rats; Receptors, Metabotropic Glutamate; Stereoisomerism; Type C Phospholipases | 1999 |
Activation of N-methyl-D-aspartate receptors reverses desensitization of metabotropic glutamate receptor, mGluR5, in native and recombinant systems.
Topics: Animals; Brain; Cycloleucine; Electrophysiology; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neuroprotective Agents; Oocytes; Phosphoprotein Phosphatases; Phosphorylation; Rats; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Xenopus | 1999 |
Modulation of a slowly inactivating potassium current, I(D), by metabotropic glutamate receptor activation in cultured hippocampal pyramidal neurons.
Topics: Action Potentials; Animals; Cells, Cultured; Cycloleucine; Electric Conductivity; GTP-Binding Proteins; Membrane Potentials; Mice; Patch-Clamp Techniques; Potassium Channels; Pyramidal Cells; Receptors, Metabotropic Glutamate; Time Factors | 1999 |
Effects of metabotropic glutamate receptor activation in auditory thalamus.
Topics: Animals; Auditory Pathways; Cycloleucine; Electric Conductivity; Electric Impedance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; In Vitro Techniques; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sodium; Sodium-Calcium Exchanger; Thalamus | 1999 |
Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Phenylacetates; Pyridines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Thalamus | 1999 |
Entire course and distinct phases of day-lasting depression of miniature EPSC amplitudes in cultured Purkinje neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Cycloleucine; Evoked Potentials; Fetus; Kinetics; Neuroprotective Agents; Patch-Clamp Techniques; Potassium; Purkinje Cells; Rats; Rats, Wistar; Reaction Time | 1999 |
Synaptic depression induced by pharmacological activation of metabotropic glutamate receptors in the perirhinal cortex in vitro.
Topics: Animals; Cycloleucine; Cyclopropanes; Electric Stimulation; Entorhinal Cortex; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Glycine; Hippocampus; Male; Neocortex; Neuronal Plasticity; Organ Culture Techniques; Propionates; Rats; Rats, Inbred Strains; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Synaptic Transmission; Temporal Lobe | 1999 |
Functional activation of punch-cultured magnocellular neuroendocrine cells by glutamate receptor subtypes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine Vasopressin; Calcium; Cell Culture Techniques; Cells, Cultured; Cycloleucine; Excitatory Amino Acid Agonists; Fetus; Kainic Acid; N-Methylaspartate; Neurons; Neurophysins; Neurosecretory Systems; Patch-Clamp Techniques; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Supraoptic Nucleus | 1999 |
Study of adenosine A2 receptors in membrane preparations from optic tectum of chicks.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Membrane; Chickens; Cyclic AMP; Cycloleucine; In Vitro Techniques; Phenethylamines; Radioligand Assay; Rats; Receptors, Purinergic P1; Superior Colliculi | 1999 |
On the synchronizing mechanisms of tetanically induced hippocampal oscillations.
Topics: Action Potentials; Animals; Bicuculline; Cycloleucine; Electric Stimulation; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Models, Neurological; Oscillometry; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A; Synapses; Synaptic Transmission | 1999 |
Possible modulatory role of voltage-activated Ca(2+) currents determining the membrane properties of isolated pyramidal neurones of the rat dorsal cochlear nucleus.
Topics: Animals; Antibody Specificity; Baclofen; Calcium Channel Blockers; Calcium Channels; Cochlear Nucleus; Cycloleucine; GABA Agonists; Immunochemistry; In Vitro Techniques; Membrane Potentials; Nifedipine; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1999 |
NMDA and non-NMDA receptor-mediated excitotoxicity are potentiated in cultured striatal neurons by prior chronic depolarization.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Corpus Striatum; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Fetus; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Potassium Chloride; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Differential coupling of G-protein-linked receptors to Ca2+ mobilization through inositol(1,4,5)trisphosphate or ryanodine receptors in cerebellar granule cells in primary culture.
Topics: Animals; Binding, Competitive; Calcium; Calcium Channels; Carbachol; Cells, Cultured; Cerebellum; Cycloleucine; Fluorescent Dyes; Fura-2; GTP-Binding Proteins; Histamine; Inositol 1,4,5-Trisphosphate Receptors; Muscarinic Agonists; Norepinephrine; Rats; Receptors, Cytoplasmic and Nuclear; Ryanodine Receptor Calcium Release Channel; Virulence Factors, Bordetella | 1999 |
Group I metabotropic glutamate receptors mediate an inward current in rat substantia nigra dopamine neurons that is independent from calcium mobilization.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Chromones; Cycloleucine; Egtazic Acid; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Microscopy, Fluorescence; Neurons; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Resorcinols; Substantia Nigra; Tetrodotoxin; Thapsigargin | 1999 |
Endogenous activation of metabotropic glutamate receptors in neocortical development causes neuronal calcium oscillations.
Topics: Animals; Calcium; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Lysine; Mice; Microscopy, Fluorescence; N-Methylaspartate; Neocortex; Neuroglia; Neurons; Neuroprotective Agents; Protein Isoforms; Receptors, Metabotropic Glutamate; Time Factors | 1999 |
Evaluation of agonists and antagonists acting at Group I metabotropic glutamate receptors in the thalamus in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Phospholipid Ethers; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Thalamus | 1999 |
Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzophenanthridines; Calcium; Cycloleucine; Drug Synergism; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Membrane Potentials; Motor Neurons; N-Methylaspartate; Phenanthridines; Phenylacetates; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Spinal Cord | 1999 |
Regulation of NMDA-stimulated [14C]GABA and [3H]acetylcholine release by striatal glutamate and dopamine receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Carbon Radioisotopes; Corpus Striatum; Cycloleucine; Dopamine Agonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; N-Methylaspartate; Proline; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
The retention deficit induced by (RS)-alpha-methyl-4-carboxyphenylglycine in a lever-press learning task is blocked by selective agonists of either group I or group II metabotropic glutamate receptors.
Topics: Animals; Benzoates; Bridged Bicyclo Compounds; Cycloleucine; Dose-Response Relationship, Drug; Eating; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Learning; Male; Memory Disorders; Mice; Mice, Inbred Strains; Neuroprotective Agents; Protein Isoforms; Receptors, Metabotropic Glutamate; Resorcinols; Retention, Psychology; Time Factors | 1999 |
Regulation of substantia nigra pars reticulata neuronal activity by excitatory amino acids.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Substantia Nigra | 1999 |
Dopamine receptors and groups I and II mGluRs cooperate for long-term depression induction in rat prefrontal cortex through converging postsynaptic activation of MAP kinases.
Topics: Animals; Benzoates; Cycloleucine; Dopamine; Electric Stimulation; Enzyme Activation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Indans; Kinetics; Male; Mitogen-Activated Protein Kinases; Models, Neurological; Neuronal Plasticity; Phosphoserine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Metabotropic Glutamate | 1999 |
Activation of tyrosine receptor kinase plays a role in expression of long-term potentiation in the rat dentate gyrus.
Topics: Animals; Calcium; Cerebral Ventricles; Cycloleucine; Dentate Gyrus; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Injections, Intraventricular; Long-Term Potentiation; Male; Neuroprotective Agents; Phosphorylation; Potassium Chloride; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Synaptosomes; Tyrphostins | 1999 |
Potentiation of glutamatergic agonist-induced inositol phosphate formation by basic fibroblast growth factor is related to developmental features in hippocampal cultures: neuronal survival and glial cell proliferation.
Topics: Animals; Antimetabolites, Antineoplastic; Benzoates; Cell Division; Cell Survival; Cells, Cultured; Cellular Senescence; Cycloleucine; Cytarabine; Epidermal Growth Factor; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Fibroblast Growth Factor 2; Glutamic Acid; Glycine; Hippocampus; Inositol Phosphates; Neuroglia; Neurons; Neuroprotective Agents; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Type C Phospholipases | 1999 |
Chronic exposure to ammonia alters pathways modulating phosphorylation of microtubule-associated protein 2 in cerebellar neurons in culture.
Topics: Ammonia; Animals; Calcimycin; Calcineurin; Calcium; Cells, Cultured; Cerebellum; Cycloleucine; Drug Administration Schedule; Electrophoresis, Gel, Two-Dimensional; Excitatory Amino Acid Agonists; Ion Transport; Ionophores; Microtubule-Associated Proteins; Neurons; Phosphorylation; Protein Processing, Post-Translational; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 1999 |
Defense reaction induced by a metabotropic glutamate receptor agonist microinjected into the dorsal periaqueductal gray of rats.
Topics: Animals; Cycloleucine; Defense Mechanisms; Escape Reaction; Male; Microinjections; Neuroprotective Agents; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1999 |
Correlation of glutamate-induced apoptosis with caspase activities in cultured rat cerebral cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Caspase 1; Caspase 3; Caspases; Cell Death; Cells, Cultured; Cerebral Cortex; Chromatin; Cycloleucine; Cysteine Proteinase Inhibitors; Embryo, Mammalian; Enzyme Precursors; Excitatory Amino Acid Agonists; Glutamic Acid; Kinetics; L-Lactate Dehydrogenase; Neurons; Rats; Time Factors | 1999 |
Doc2alpha is an activity-dependent modulator of excitatory synaptic transmission.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Behavior, Animal; Calcium-Binding Proteins; Cells, Cultured; Cycloleucine; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Targeting; Hippocampus; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Neuronal Plasticity; Neuroprotective Agents; Protein Isoforms; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission | 1999 |
Long-lasting increase in cellular excitability associated with the priming of LTP induction in rat hippocampus.
Topics: Adrenergic beta-Agonists; Animals; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Indicators and Reagents; Isoproterenol; Long-Term Potentiation; Male; Microelectrodes; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1999 |
Induction of NMDA receptor-dependent long-term depression in visual cortex does not require metabotropic glutamate receptors.
Topics: Amino Acids; Animals; Cycloleucine; Depression, Chemical; Excitatory Amino Acid Antagonists; Hydrolysis; In Vitro Techniques; Methoxyhydroxyphenylglycol; Mice; Mice, Knockout; Neuronal Plasticity; Phosphatidylinositols; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Visual Cortex; Xanthenes | 1999 |
Ca2+ store-dependent potentiation of Ca2+-activated non-selective cation channels in rat hippocampal neurones in vitro.
Topics: Animals; Calcium; Cations; Cells, Cultured; Cycloleucine; Cytoplasm; Electrophysiology; Excitatory Postsynaptic Potentials; Hippocampus; Image Processing, Computer-Assisted; Inositol 1,4,5-Trisphosphate; Ion Channels; Mitochondria; Neurons; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1999 |
Locomotor activity and accumbens Fos expression driven by ventral hippocampal stimulation require D1 and D2 receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Benzazepines; Brain Chemistry; Cycloleucine; Dextroamphetamine; Dopamine Agents; Dopamine Antagonists; Excitatory Amino Acid Agonists; Genes, Immediate-Early; Glutamic Acid; Haloperidol; Hippocampus; Kainic Acid; Lidocaine; Locomotion; Male; N-Methylaspartate; Neural Pathways; Neuroprotective Agents; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1999 |
Presynaptic group 1 metabotropic glutamate receptors may contribute to the expression of long-term potentiation in the hippocampal CA1 region.
Topics: Animals; Azetidinecarboxylic Acid; Calcium; Cycloleucine; Dicarboxylic Acids; Diglycerides; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hippocampus; Long-Term Potentiation; Male; Neuroprotective Agents; Neurotransmitter Uptake Inhibitors; Presynaptic Terminals; Pyrrolidines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Synaptosomes | 1999 |
Age-related changes in synaptic function: analysis of the effect of dietary supplementation with omega-3 fatty acids.
Topics: Aging; Animals; Arachidonic Acid; Cycloleucine; Dentate Gyrus; Docosahexaenoic Acids; Eating; Excitatory Postsynaptic Potentials; Fatty Acids, Omega-3; Glutamic Acid; Long-Term Potentiation; Male; Neurons; Neuroprotective Agents; Perforant Pathway; Potassium Chloride; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Synaptosomes | 1999 |
Contribution of Ca(2+)-permeable AMPA/KA receptors to glutamate-induced Ca(2+) rise in embryonic lumbar motoneurons in situ.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channel Blockers; Cycloleucine; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Lumbosacral Region; Motor Neurons; Neurotoxins; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Spider Venoms; Spinal Cord | 2000 |
Neuroprotective action of group I metabotropic glutamate receptor agonists against oxygen-glucose deprivation-induced neuronal death.
Topics: Animals; Cell Death; Cell Hypoxia; Cells, Cultured; Cerebellum; Cycloleucine; Electrophoresis, Agar Gel; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glucose; Glycine; In Situ Nick-End Labeling; Indans; Indoles; Maleimides; Neurons; Neuroprotective Agents; Protein Kinase C; Rats; Receptors, Metabotropic Glutamate; Resorcinols | 2000 |
Metabotropic glutamate receptors and blockade of glial Krebs cycle depress glycinergic synaptic currents of mouse hypoglossal motoneurons.
Topics: Animals; Animals, Newborn; Aspartic Acid; Citric Acid Cycle; Cycloleucine; Cyclopropanes; Excitatory Postsynaptic Potentials; Female; Glycine; Hypoglossal Nerve; Male; Membrane Potentials; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; Motor Neurons; Neuroglia; Neuroprotective Agents; Patch-Clamp Techniques; Propionates; Receptors, Metabotropic Glutamate; Synapses | 2000 |
Calcium dynamics of neocortical ventricular zone cells.
Topics: Animals; Calcium; Cerebral Ventricles; Cycloleucine; Embryo, Mammalian; Embryonic and Fetal Development; Intracellular Membranes; Mice; Neocortex; Neurons; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Ryanodine Receptor Calcium Release Channel | 2000 |
Alterations in calcium-mediated signal transduction after traumatic injury of cortical neurons.
Topics: Animals; Brain Injuries; Calcium; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Neuroglia; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Thapsigargin | 1999 |
Evaluation of the activity of a novel metabotropic glutamate receptor antagonist (+/-)-2-amino-2-(3-cis and trans-carboxycyclobutyl-3-(9-thioxanthyl)propionic acid) in the in vitro neonatal spinal cord and in an in vivo pain model.
Topics: Acetic Acid; Animals; Animals, Newborn; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Mice; Motor Neurons; Neuroprotective Agents; Nociceptors; Pain; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord; Spinal Nerve Roots; Stereoisomerism | 2000 |
Sustained behavioral stimulation following selective activation of group I metabotropic glutamate receptors in rat striatum.
Topics: Animals; Behavior, Animal; Benzazepines; Calcium; Corpus Striatum; Cycloleucine; Dantrolene; Dose-Response Relationship, Drug; Male; Methoxyhydroxyphenylglycol; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 2000 |
Group II metabotropic glutamate receptors are a common target of N-anisoyl-GABA and 1S,3R-ACPD in enhancing ACh release in the prefrontal cortex of freely moving SHRSP.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Dicarboxylic; Animals; Anisoles; Benzoates; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Indans; Male; Microdialysis; Perfusion; Prefrontal Cortex; Quinoxalines; Rats; Rats, Inbred SHR; Receptors, AMPA; Receptors, Metabotropic Glutamate; Thalamic Nuclei; Wakefulness | 2000 |
Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Cell Survival; Choline O-Acetyltransferase; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Situ Nick-End Labeling; In Vitro Techniques; Kainic Acid; Male; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord | 2000 |
Selective blockade of mGlu5 metabotropic glutamate receptors protects rat hepatocytes against hypoxic damage.
Topics: Animals; Animals, Newborn; Blotting, Western; Cell Hypoxia; Cells, Cultured; Cycloleucine; Excitatory Amino Acid Agonists; Glycine; Immunohistochemistry; Liver; Male; Neuroprotective Agents; Pyridines; Quisqualic Acid; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2000 |
Activity-dependent activation of presynaptic metabotropic glutamate receptors in locus coeruleus.
Topics: Aminobutyrates; Animals; Cycloleucine; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Feedback; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Locus Coeruleus; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Metabotropic Glutamate; Receptors, Presynaptic | 2000 |
Group I, II, and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion.
Topics: Alanine; Amino Acids, Dicarboxylic; Animals; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Ganglia, Invertebrate; In Vitro Techniques; Male; Methoxyhydroxyphenylglycol; Motor Neurons; Nephropidae; Nerve Net; Quisqualic Acid; Receptors, Metabotropic Glutamate; Stomach | 2000 |
Mobilisation of intracellular Ca2+ by mGluR5 metabotropic glutamate receptor activation in neonatal rat cultured dorsal root ganglia neurones.
Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Cells, Cultured; Cycloleucine; Cyclopropanes; Dantrolene; Fluorescence; Ganglia, Spinal; Glutamic Acid; Glycine; Indans; Phenylacetates; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Ryanodine; Ryanodine Receptor Calcium Release Channel; Stereoisomerism | 2000 |
Axonal stratification patterns and glutamate-gated conductance mechanisms in zebrafish retinal bipolar cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Axons; Chlorides; Cycloleucine; Dendrites; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glutamic Acid; In Vitro Techniques; Isoquinolines; Kainic Acid; Neurons; Picrotoxin; Retina; Strychnine; Zebrafish | 2000 |
Behavioural evidence supporting a differential role for group I and II metabotropic glutamate receptors in spinal nociceptive transmission.
Topics: Amino Acids, Dicarboxylic; Animals; Behavior, Animal; Chronic Disease; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Indans; Injections, Spinal; Nociceptors; Pain Threshold; Physical Stimulation; Receptors, Metabotropic Glutamate; Resorcinols; Sheep; Spinal Cord; Synaptic Transmission | 2000 |
(+)-MCPG induces PKCepsilon translocation in cortical synaptosomes through a PLD-coupled mGluR.
Topics: Animals; Benzoates; Cerebral Cortex; Chelating Agents; Cycloleucine; Cyclopropanes; Egtazic Acid; Enzyme Activation; Excitatory Amino Acid Antagonists; Glycine; Isoenzymes; Male; Neurons; Neuroprotective Agents; Phospholipase D; Presynaptic Terminals; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction; Synaptosomes | 2000 |
Differential expression of group I metabotropic glutamate receptors in functionally distinct hippocampal interneurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Benzoates; Cycloleucine; Excitatory Amino Acid Antagonists; GABA Antagonists; Gene Expression; Glycine; Hippocampus; Interneurons; Neuroprotective Agents; Patch-Clamp Techniques; Periodicity; Picrotoxin; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; Tetrodotoxin | 2000 |
Dendritic depolarization efficiently attenuates low-threshold calcium spikes in thalamic relay cells.
Topics: Animals; Calcium; Calcium Channels, T-Type; Carbachol; Cats; Cholinergic Agonists; Cycloleucine; Dendrites; Electrophysiology; Geniculate Bodies; In Vitro Techniques; Membrane Potentials; Neural Pathways; Neuroprotective Agents; Periodicity; Pons; Receptors, Metabotropic Glutamate; Receptors, Muscarinic | 2000 |
Descending facilitatory modulation of a behavioral nociceptive response by stimulation in the adult rat anterior cingulate cortex.
Topics: Animals; Behavior, Animal; Cycloleucine; Electric Stimulation; Gyrus Cinguli; Male; Medulla Oblongata; Microinjections; Neural Pathways; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reflex; Spinal Cord; Stimulation, Chemical | 2000 |
Reducing conditions differentially affect the functional and structural properties of group-I and -II metabotropic glutamate receptors.
Topics: Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Carbachol; Cell Membrane; Cerebellum; CHO Cells; Cholinergic Agonists; Colforsin; Cricetinae; Cyclic AMP; Cycloleucine; Cyclopropanes; Dimerization; Dithiothreitol; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Humans; Kidney; Neurons; Neuroprotective Agents; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Signal Transduction | 2000 |
Ionic mechanisms underlying repetitive high-frequency burst firing in supragranular cortical neurons.
Topics: Action Potentials; Aging; Animals; Calcium; Chelating Agents; Cycloleucine; Egtazic Acid; Female; Ferrets; In Vitro Techniques; Lidocaine; Male; Neurons; Phenytoin; Potassium; Potassium Channels; Pyramidal Cells; Sodium; Sodium Channels; Tetrodotoxin; Visual Cortex | 2000 |
Physiological activation of presynaptic metabotropic glutamate receptors increases intracellular calcium and glutamate release.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Brain Stem; Calcium; Chromones; Cycloleucine; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorometry; Glutamic Acid; Glycine Agents; GTP-Binding Proteins; In Vitro Techniques; Lampreys; Larva; Membrane Potentials; N-Methylaspartate; Neuronal Plasticity; Neuroprotective Agents; Patch-Clamp Techniques; Presynaptic Terminals; Quisqualic Acid; Receptors, Metabotropic Glutamate; Strychnine; Tetrodotoxin | 2000 |
Regional distribution and pharmacological characteristics of [3H]N-acetyl-aspartyl-glutamate (NAAG) binding sites in rat brain.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain; Brain Chemistry; Carboxypeptidases; Cold Temperature; Cycloleucine; Cyclopropanes; Dipeptides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamate Carboxypeptidase II; Glycine; Kainic Acid; Male; Nerve Tissue Proteins; Phosphoserine; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrazoles | 2001 |
Behavioural activity of (S)-3,5-DHPG, a selective agonist of group I metabotropic glutamate receptors.
Topics: Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Cycloleucine; Exploratory Behavior; Glycine; Long-Term Potentiation; Male; Motor Activity; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols | 2000 |
Dedifferentiation of intrinsic response properties of motoneurons in organotypic cultures of the spinal cord of the adult turtle.
Topics: Action Potentials; Age Factors; Animals; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cesium; Chlorides; Ciliary Neurotrophic Factor; Cycloleucine; Electrophysiology; Glial Cell Line-Derived Neurotrophic Factor; Motor Neurons; Nerve Growth Factors; Nerve Tissue Proteins; Neuroprotective Agents; Neurotrophin 3; Organ Culture Techniques; Spinal Cord; Synapses; Tetraethylammonium; Tetrodotoxin; Turtles | 2000 |
Expression of functional metabotropic glutamate receptors in primary cultured rat osteoblasts. Cross-talk with N-methyl-D-aspartate receptors.
Topics: Animals; Base Sequence; Calcium; Cells, Cultured; Cycloleucine; DNA Primers; Membrane Potentials; Osteoblasts; Rats; Receptor Cross-Talk; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Parathyroid Hormone; Reverse Transcriptase Polymerase Chain Reaction | 2000 |
Activation of group I metabotropic glutamate receptors induces long-term depression at sensory synapses in superficial spinal dorsal horn.
Topics: Animals; Cycloleucine; Depression, Chemical; Enzyme Inhibitors; Estrenes; Excitatory Postsynaptic Potentials; Female; GTP-Binding Proteins; In Vitro Techniques; Male; Nerve Fibers, Myelinated; Neuronal Plasticity; Neurons, Afferent; Patch-Clamp Techniques; Pertussis Toxin; Posterior Horn Cells; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Stereoisomerism; Synapses; Type C Phospholipases; Virulence Factors, Bordetella | 2000 |
Glutamate-mediated neuroprotection against N-methyl-D-aspartate toxicity: a role for metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cell Death; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Neuroprotective Agents; Oligodeoxyribonucleotides, Antisense; Organ Culture Techniques; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Tetrodotoxin | 2000 |
Expression of metabotropic glutamate receptors in murine thymocytes and thymic stromal cells.
Topics: Animals; Blotting, Western; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line; Cyclic AMP; Cycloleucine; Flow Cytometry; Gene Expression; Hydrolysis; Male; Mice; Mice, Inbred C57BL; Neuroimmunomodulation; Neuroprotective Agents; Phosphatidylinositol Phosphates; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stromal Cells; Thymus Gland | 2000 |
Plateau potential-dependent windup of the response to primary afferent stimuli in rat dorsal horn neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Membrane; Chelating Agents; Cycloleucine; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Male; Neuroprotective Agents; Nifedipine; Nociceptors; Organ Culture Techniques; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tetrodotoxin | 2000 |
Control of dendritic outputs of inhibitory interneurons in the lateral geniculate nucleus.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cats; Cycloleucine; Dendrites; GABA Antagonists; Geniculate Bodies; Glutamic Acid; In Vitro Techniques; Interneurons; Magnesium; Muscarinic Agonists; Neural Inhibition; Nicotinic Agonists; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tetrodotoxin | 2000 |
Involvement of metabotropic glutamate receptors in ischemia-induced taurine release in the developing and adult hippocampus.
Topics: Aging; Animals; Brain Ischemia; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamates; Glycine; Hippocampus; In Vitro Techniques; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; Neurons; Receptors, Metabotropic Glutamate; Taurine | 2000 |
Dendritic release of glutamate suppresses synaptic inhibition of pyramidal neurons in rat neocortex.
Topics: Action Potentials; Animals; Botulinum Toxins; Calcium; Cycloleucine; Dendrites; Egtazic Acid; Electrophysiology; Glutamic Acid; Guanosine Diphosphate; Interneurons; Neocortex; Neural Inhibition; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission; Thionucleotides | 2000 |
Slow synaptic inhibition mediated by metabotropic glutamate receptor activation of GIRK channels.
Topics: Amino Acids, Dicarboxylic; Animals; Baclofen; Chelating Agents; Cycloleucine; Egtazic Acid; Electrophysiology; Excitatory Amino Acid Antagonists; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GABA Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Membrane Potentials; Neural Inhibition; Neuroprotective Agents; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Metabotropic Glutamate; Songbirds; Synapses; Tetraethylammonium; Tetrodotoxin; Thionucleotides | 2000 |
Inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release evoked by metabotropic agonists and backpropagating action potentials in hippocampal CA1 pyramidal neurons.
Topics: Action Potentials; Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Chelating Agents; Cycloleucine; Dendrites; Dose-Response Relationship, Drug; Egtazic Acid; Fluorescent Dyes; Hippocampus; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Metabotropic Glutamate | 2000 |
Activation of metabotropic glutamate receptors increases extracellular adenosine in vivo.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Male; Methoxyhydroxyphenylglycol; Microdialysis; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Somatosensory Cortex | 2000 |
Differential actions of spinal analgesics on mono-versus polysynaptic Adelta-fibre-evoked field potentials in superficial spinal dorsal horn in vitro.
Topics: Action Potentials; Analgesics; Analgesics, Opioid; Animals; Clonidine; Cycloleucine; Dose-Response Relationship, Drug; In Vitro Techniques; Injections, Spinal; Morphine; Nerve Fibers, Myelinated; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Metabotropic Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synaptic Transmission | 2000 |
Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cloning, Molecular; Cycloleucine; Cytosol; Enzyme Activation; Glutathione Transferase; Hippocampus; Mutagenesis, Site-Directed; Neuroprotective Agents; Phosphorylation; Plasmids; Point Mutation; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Signal Transduction | 2001 |
Relative contribution by GABA or glycine to Cl(-)-mediated synaptic transmission on rat hypoglossal motoneurons in vitro.
Topics: Animals; Chlorides; Cycloleucine; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Hypoglossal Nerve; In Vitro Techniques; Motor Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Glycine; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrodotoxin | 2000 |
Dual modulation of excitatory synaptic transmission by agonists at group I metabotropic glutamate receptors in the rat spinal dorsal horn.
Topics: Animals; Benzoates; Bicuculline; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glycine; In Vitro Techniques; Kinetics; Magnesium; Male; Methoxyhydroxyphenylglycol; Nerve Fibers; Phenylacetates; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord; Strychnine; Substantia Gelatinosa; Synaptic Transmission | 2000 |
Activation of metabotropic glutamate receptors inhibits synapsin I phosphorylation in visceral sensory neurons.
Topics: Aminobutyrates; Animals; Cycloleucine; Exocytosis; Gene Expression Regulation; Membrane Potentials; Nerve Tissue Proteins; Neurons, Afferent; Nodose Ganglion; Patch-Clamp Techniques; Phosphorylation; Potassium Chloride; Protein Isoforms; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Synapsins | 2000 |
Slow dorsal-ventral rhythm generator in the lamprey spinal cord.
Topics: Animals; Bicuculline; Biological Clocks; Cycloleucine; GABA Antagonists; GABA-A Receptor Antagonists; In Vitro Techniques; Lampreys; Membrane Potentials; Motor Activity; Periodicity; Receptors, Glycine; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Strychnine | 2001 |
cAMP-dependent presynaptic regulation of spontaneous glycinergic IPSCs in mechanically dissociated rat spinal cord neurons.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Barium; Cadmium; Calcium; Colforsin; Cyclic AMP; Cycloleucine; Evoked Potentials; Excitatory Amino Acid Agonists; In Vitro Techniques; Neural Inhibition; Neurons; Patch-Clamp Techniques; Potassium; Presynaptic Terminals; Propionates; Rats; Rats, Wistar; Receptors, Glycine; Receptors, Metabotropic Glutamate; Spinal Cord | 2001 |
Upregulation of preprodynorphin and preproenkephalin mRNA expression by selective activation of group I metabotropic glutamate receptors in characterized primary cultures of rat striatal neurons.
Topics: Animals; Animals, Newborn; Cells, Cultured; Corpus Striatum; Cycloleucine; Dynorphins; Enkephalins; Gene Expression; Immunohistochemistry; In Situ Hybridization; Methoxyhydroxyphenylglycol; Neurons; Neuroprotective Agents; Nucleus Accumbens; Phenotype; Protein Precursors; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; RNA, Messenger | 2001 |
Sustained L-type calcium currents in dissociated deep dorsal horn neurons of the rat: characteristics and modulation.
Topics: Animals; Baclofen; Barium; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cycloleucine; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Agonists; Glycine; In Vitro Techniques; Male; Membrane Potentials; Nifedipine; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols | 2001 |
Traumatic injury of cultured astrocytes alters inositol (1,4,5)-trisphosphate-mediated signaling.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Injuries; Cells, Cultured; Cycloleucine; Estrenes; Extracellular Space; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Neomycin; Neuroprotective Agents; Phosphodiesterase Inhibitors; Protein Synthesis Inhibitors; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Stress, Mechanical; Type C Phospholipases | 2001 |
Metabotropic glutamate receptors modify ionotropic glutamate responses in neocortical pyramidal cells and interneurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Auditory Cortex; Cycloleucine; Excitatory Postsynaptic Potentials; GluK2 Kainate Receptor; Guanosine Diphosphate; Interneurons; Male; Neocortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synaptic Transmission; Thionucleotides | 2001 |
PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex.
Topics: Animals; Axons; Carbachol; Cell Differentiation; Cycloleucine; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Isoenzymes; Mice; Mice, Knockout; Neuroprotective Agents; Phosphatidylinositols; Phospholipase C beta; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Somatosensory Cortex; Synaptic Transmission; Synaptosomes; Type C Phospholipases | 2001 |
Activation of metabotropic glutamate receptors induces gamma frequency oscillations in the rat dentate gyrus in vivo.
Topics: Animals; Benzoates; Cycloleucine; Dentate Gyrus; Electroencephalography; Excitatory Amino Acid Antagonists; Glycine; Male; Rats; Receptors, Metabotropic Glutamate; Time Factors | 2001 |
Tetanic stimulation and metabotropic glutamate receptor agonists modify synaptic responses and protein kinase activity in rat auditory cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Auditory Cortex; Cyclic AMP-Dependent Protein Kinases; Cycloleucine; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Long-Term Potentiation; Male; Naphthalenes; Neural Inhibition; Neurons; Neuroprotective Agents; Phosphorylation; Protein Kinase C; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2001 |
Expression and regulation of Na pump isoforms in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Cerebellum; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Isoenzymes; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Potassium Radioisotopes; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 2001 |
The M1 receptor is required for muscarinic activation of mitogen-activated protein (MAP) kinase in murine cerebral cortical neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Carbachol; Cells, Cultured; Cerebral Cortex; Cycloleucine; Enzyme Activation; Hippocampus; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Muscarinic Agonists; Neurons; Phosphatidylinositols; Receptor, Muscarinic M1; Receptors, Muscarinic | 2001 |
The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures.
Topics: Animals; Coloring Agents; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Immunohistochemistry; In Vitro Techniques; Microtubule-Associated Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurotoxins; Propidium; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Staining and Labeling | 2001 |
Group I metabotropic glutamate receptors are expressed in the chicken retina and by cultured retinal amacrine cells.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Blotting, Western; Calcium Signaling; Cells, Cultured; Chickens; Cycloleucine; Excitatory Amino Acid Agonists; Eye Proteins; Fluorescent Antibody Technique, Indirect; gamma-Aminobutyric Acid; Glycine; Molecular Sequence Data; Molecular Weight; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Retina | 2001 |
Inhibition of choline acetyltransferase by excitatory amino acids as a possible mechanism for cholinergic dysfunction in the central nervous system.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Chick Embryo; Choline O-Acetyltransferase; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Neurons; NG-Nitroarginine Methyl Ester; Propionates; Quisqualic Acid; Retina; Signal Transduction; Tetrodotoxin; Trifluoperazine; Verapamil | 2001 |
mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C.
Topics: Animals; Calcium; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Mice; Protein Kinase C; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tetradecanoylphorbol Acetate; Xenopus laevis | 2001 |
Stimulation of Na-K-2Cl cotransporter in neurons by activation of Non-NMDA ionotropic receptor and group-I mGluRs.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Calcium; Carrier Proteins; Cells, Cultured; Chromones; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Fetus; Glycine; Neurons; Neuroprotective Agents; Phosphorylation; Potassium; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Rubidium Radioisotopes; Sodium-Potassium-Chloride Symporters | 2001 |
Potentiation of a metabotropic glutamatergic response following NMDA receptor activation in rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cycloleucine; Excitatory Amino Acid Agonists; Hippocampus; N-Methylaspartate; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1994 |
Role of metabotropic glutamate receptors in vasopressin and oxytocin release.
Topics: Aminobutyrates; Animals; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hypothalamo-Hypophyseal System; In Vitro Techniques; Indans; Male; Neurons; Neuroprotective Agents; Osmolar Concentration; Oxytocin; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Vasopressins | 2001 |
Activation of metabotropic glutamate receptor 1 accelerates NMDA receptor trafficking.
Topics: Animals; Blotting, Western; Botulinum Toxins, Type A; Cell Membrane; Cells, Cultured; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exocytosis; Fluorescent Antibody Technique; Ion Channel Gating; Membrane Potentials; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Oocytes; Patch-Clamp Techniques; Protein Transport; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptosomal-Associated Protein 25; Transfection; Xenopus | 2001 |
Ca2+-dependent regulation of synaptic delta2 glutamate receptor density in cultured rat Purkinje neurons.
Topics: Actins; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Calpain; Cells, Cultured; Cerebellum; Cycloleucine; Dendrites; Endocytosis; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Intracellular Fluid; Neuroprotective Agents; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Synaptic Membranes; Synaptic Transmission | 2001 |
Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Amino Acids; Animals; Benzoates; Bridged Bicyclo Compounds; Corticosterone; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Neuroprotective Agents; Paraventricular Hypothalamic Nucleus; Phenylacetates; Propionates; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Xanthenes | 2001 |
Activation of a latent respiratory motor pathway by stimulation of neurons in the medullary chemoreceptor area of the rat.
Topics: Animals; Carbon Dioxide; Chemoreceptor Cells; Cycloleucine; Dose-Response Relationship, Drug; Electrophysiology; Female; Medulla Oblongata; Microinjections; Neural Pathways; Neurons; Phrenic Nerve; Pulmonary Gas Exchange; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Recovery of Function; Respiration, Artificial; Respiratory Physiological Phenomena; Spinal Cord; Stimulation, Chemical; Tidal Volume; Vagotomy | 2001 |
Visualization of IP(3) dynamics reveals a novel AMPA receptor-triggered IP(3) production pathway mediated by voltage-dependent Ca(2+) influx in Purkinje cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Blood Proteins; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Cycloleucine; Cytoplasm; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Genetic Vectors; Glutamic Acid; Glycine; Green Fluorescent Proteins; Indicators and Reagents; Inositol 1,4,5-Trisphosphate; Luminescent Proteins; Membrane Potentials; Mice; Mice, Inbred ICR; Neuroprotective Agents; Patch-Clamp Techniques; Phosphoproteins; Purkinje Cells; Receptors, AMPA; Receptors, Metabotropic Glutamate; Sindbis Virus | 2001 |
Metabotropic glutamate receptors stimulate phospholipase D via different pathways in the adult and neonate rat hippocampus.
Topics: Aging; Animals; Animals, Newborn; Cycloleucine; Cyclopropanes; Glycine; Hippocampus; Kinetics; Methoxyhydroxyphenylglycol; Phospholipase D; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 2001 |
Retrograde modulation of transmitter release by postsynaptic subtype 1 metabotropic glutamate receptors in the rat cerebellum.
Topics: Animals; Cerebellum; Cycloleucine; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Male; Mice; Mice, Knockout; Nerve Fibers; Neurotransmitter Agents; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission | 2001 |
(1R,3S)-1-Aminocyclopentane-1,3-dicarboxylic acid (RS-ACPD) reduces intracellular glutamate levels in astrocytes.
Topics: Animals; Astrocytes; Biological Transport; Cell Size; Cells, Cultured; Cycloleucine; Enzyme Inhibitors; Glutamic Acid; Glutaminase; Hippocampus; Intracellular Fluid; Molecular Conformation; Neuroprotective Agents; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Potassium-Exchanging ATPase | 2001 |
Magnesium decreases arterial pressure and inhibits cardiovascular responses induced by N-methyl-D-aspartate and metabotropic glutamate receptors stimulation in rostral ventrolateral medulla.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Heart Rate; Magnesium; Magnesium Chloride; Magnesium Sulfate; Male; Medulla Oblongata; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2001 |
Development of cytotoxic cerebral edema in rats following intracaudatum injection of tACPD, an agonist of metabotropic glutamate receptors.
Topics: Animals; Brain Edema; Cycloleucine; Male; Microinjections; Rats; Receptors, Metabotropic Glutamate | 2000 |
Presynaptic inhibition of GABAergic miniature currents by metabotropic glutamate receptor in the rat CNS.
Topics: Adenylyl Cyclases; Animals; Basal Nucleus of Meynert; Calbindins; Calcium; Cell Size; Choline O-Acetyltransferase; Cycloleucine; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Ion Channels; Neural Inhibition; Neuroprotective Agents; Potassium Channel Blockers; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; S100 Calcium Binding Protein G; Synaptic Transmission | 2002 |
Neuroprotective effects of N-acetylaspartylglutamate in a neonatal rat model of hypoxia-ischemia.
Topics: Amino Acids; Animals; Animals, Newborn; Brain; Carboxypeptidases; Cyclic AMP; Cycloleucine; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate Carboxypeptidase II; Hippocampus; Hypoxia-Ischemia, Brain; Neurons; Neuroprotective Agents; Organophosphorus Compounds; Propionates; Rats; Rats, Sprague-Dawley; Xanthenes | 2002 |
Cellular mechanisms of the slow (<1 Hz) oscillation in thalamocortical neurons in vitro.
Topics: Animals; Calcium Channel Blockers; Cats; Cycloleucine; Delta Rhythm; Electroencephalography; Excitatory Amino Acid Antagonists; GABA Antagonists; Geniculate Bodies; In Vitro Techniques; Membrane Potentials; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Receptors, Metabotropic Glutamate; Sleep; Thalamus | 2002 |
Chronic ethanol treatment and withdrawal alter ACPD-evoked calcium signals in developing Purkinje neurons.
Topics: Action Potentials; Animals; Calcium Signaling; Cell Differentiation; Cells, Cultured; Central Nervous System Depressants; Cerebellum; Cycloleucine; Embryo, Mammalian; Ethanol; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Substance Withdrawal Syndrome | 2002 |
Modulation of dendritic release of dopamine by metabotropic glutamate receptors in rat substantia nigra.
Topics: Animals; Cycloleucine; Dendritic Cells; Dopamine; Excitatory Amino Acid Agonists; In Vitro Techniques; Male; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Tritium | 2002 |
Effect of ionotropic and metabotropic glutamate agonists and D-aspartate on prolactin release from anterior pituitary cells.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Agonists; Female; Pituitary Gland, Anterior; Prolactin; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Metabotropic Glutamate | 2002 |
Ionotropic glutamate receptors mediate juvenile hormone synthesis in the cockroach, Diploptera punctata.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cockroaches; Corpora Allata; Cycloleucine; Cytosol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Juvenile Hormones; Kainic Acid; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Receptors, Metabotropic Glutamate | 2002 |
Stereoselective synthesis of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid via C-H insertion of alkylidenecarbene.
Topics: Cycloleucine; Dicarboxylic Acids; Indicators and Reagents; Ketones; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Receptors, Metabotropic Glutamate; Stereoisomerism | 2002 |
Effects of excitatory modulation on intrinsic properties of turtle motoneurons.
Topics: Animals; Cycloleucine; Drug Combinations; Electrophysiology; In Vitro Techniques; Motor Neurons; Muscarine; Nifedipine; Serotonin; Spinal Cord; Turtles | 2002 |
The activation of metabotropic glutamate receptors differentially affects GABA and alpha-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats.
Topics: alpha-MSH; Animals; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycine; Hypothalamus; Indans; Male; Neuroprotective Agents; Pituitary Gland, Posterior; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 2002 |
Activation of brainstem metabotropic glutamate receptors inhibits spinal nociception in adult rats.
Topics: Analgesics; Animals; Brain Stem; Cycloleucine; Electric Stimulation; Excitatory Amino Acid Agonists; Male; Medulla Oblongata; Microinjections; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reflex; Spinal Cord; Stimulation, Chemical | 2002 |
Metabotropic and NMDA glutamate receptor interactions with osmotic stimuli in supraoptic neurons.
Topics: Animals; Calcium Signaling; Cells, Cultured; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Agonists; Female; Glycine; Image Processing, Computer-Assisted; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Neurosecretory Systems; Osmolar Concentration; Pregnancy; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Supraoptic Nucleus | 2002 |
Spatial segregation and interaction of calcium signalling mechanisms in rat hippocampal CA1 pyramidal neurons.
Topics: Action Potentials; Animals; Calcium; Calcium Signaling; Cycloleucine; Dendrites; Hippocampus; Inositol 1,4,5-Trisphosphate; Neuroprotective Agents; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2002 |
Group I metabotropic glutamate receptor-mediated enhancement of dopamine cell burst firing in rat ventral tegmental area in vitro.
Topics: Action Potentials; Animals; Apamin; Benzoates; Biological Clocks; Cycloleucine; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Resorcinols; Ventral Tegmental Area | 2002 |
Activation of glutamate receptors inhibits Na/K-ATPase of cerebellum granule cells.
Topics: Alkaloids; Animals; Benzoates; Benzophenanthridines; Cerebellum; Cycloleucine; Cysteine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Glutamates; Glycine; Male; Mice; Mice, Inbred AKR; N-Methylaspartate; Neurons; Phenanthridines; Receptors, Glutamate; Sodium-Potassium-Exchanging ATPase | 2002 |
Enantioselective synthesis of the excitatory amino acid (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid.
Topics: Cycloleucine; Excitatory Amino Acids; Molecular Structure; Stereoisomerism | 2002 |
Carbon monoxide and metabotropic glutamate receptors in rat nucleus tractus solitarii: participation in cardiovascular effect.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Carbon Monoxide; Cardiovascular System; Cycloleucine; Deuteroporphyrins; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Heme Oxygenase (Decyclizing); Hemin; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Solitary Nucleus | 2002 |
Cell type-selective expression of green fluorescent protein and the calcium indicating protein, yellow cameleon, in rat cortical primary cultures.
Topics: Animals; Antigens, Viral; Astrocytes; Calcium; Cell Culture Techniques; Cerebral Cortex; Cycloleucine; Gene Expression Regulation; Genetic Vectors; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Immediate-Early Proteins; Immunohistochemistry; Indicators and Reagents; Luminescent Proteins; Microscopy, Confocal; Neurons; Peptide Elongation Factor 1; Phosphopyruvate Hydratase; Promoter Regions, Genetic; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Transfection | 2002 |
Glutamate induces different neuronal conditioned responses than ACPD when used as a locally ionophoresed unconditioned stimulus in the cat motor cortex.
Topics: Acoustic Stimulation; Administration, Topical; Animals; Conditioning, Psychological; Cycloleucine; Discrimination, Psychological; Glutamic Acid; Humans; Iontophoresis; Motor Cortex; Neurons; Receptors, Metabotropic Glutamate | 2002 |
Effects of calcium and glutamate receptor agonists on leaf consumption by lepidopteran neonates.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Feeding Behavior; Kainic Acid; Lepidoptera; N-Methylaspartate; Plant Leaves | 2003 |
Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid.
Topics: Amino Acids; Animals; Binding, Competitive; Cerebral Cortex; Cyclization; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamates; In Vitro Techniques; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 2002 |
Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors.
Topics: Acamprosate; Animals; Binding Sites; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Taurine | 2002 |
Different roles of group I and group II metabotropic glutamate receptors on phencyclidine-induced dopamine release in the rat prefrontal cortex.
Topics: Animals; Anticonvulsants; Cycloleucine; Cyclopropanes; Dopamine; Dopamine Agents; Excitatory Amino Acid Antagonists; Extracellular Space; Glycine; Hallucinogens; Male; Microdialysis; Neuroprotective Agents; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Time Factors | 2003 |
Antagonism of glutamatergic metabotropic receptors in the NTS of awake rats does not affect the gain of the baroreflex.
Topics: Animals; Baroreflex; Benzoates; Blood Pressure; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Heart Rate; Male; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Solitary Nucleus | 2003 |
A pharmacological analysis of the contractile effects of glutamate on rat and human isolated gut smooth muscle strips.
Topics: Aged; Animals; Aspartic Acid; Cycloleucine; Evoked Potentials, Motor; Female; Gastric Fundus; Glutamic Acid; Humans; In Vitro Techniques; Intestine, Large; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Proline; Quisqualic Acid; Rats; Receptors, Glutamate; Rectum; Stomach | 2002 |
Actions of Group I and Group II metabotropic glutamate receptor ligands on 5-hydroxytryptamine release in the rat cerebral cortex in vivo: differential roles in the regulation of central serotonergic neurotransmission.
Topics: Amino Acids, Dicarboxylic; Analysis of Variance; Anesthetics, Local; Animals; Benzoates; Calcium; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Ligands; Male; Microdialysis; Potassium Chloride; Pyridines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Serotonin; Synaptic Transmission; Tetrodotoxin | 2003 |
Translation of clock rhythmicity into neural firing in suprachiasmatic nucleus requires mGluR-PLCbeta4 signaling.
Topics: Action Potentials; Animals; Biological Clocks; Cell Cycle Proteins; Circadian Rhythm; Cycloleucine; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glutamic Acid; Isoenzymes; Mice; Mice, Knockout; Mutation; Neurons; Neuroprotective Agents; Nuclear Proteins; Organ Culture Techniques; Period Circadian Proteins; Phospholipase C beta; Receptors, Metabotropic Glutamate; Signal Transduction; Suprachiasmatic Nucleus; Synaptic Transmission; Type C Phospholipases | 2003 |
Carbon monoxide mediates vasodilator effects of glutamate in isolated pressurized cerebral arterioles of newborn pigs.
Topics: Animals; Animals, Newborn; Arterioles; Brain; Carbon Monoxide; Cycloleucine; Endothelium, Vascular; Enzyme Inhibitors; Fluorescent Antibody Technique; Glutamic Acid; Heme Oxygenase (Decyclizing); In Vitro Techniques; Isoenzymes; Mesoporphyrins; Pressure; Receptors, N-Methyl-D-Aspartate; Swine; Vasodilation | 2003 |
Synaptically activated Ca2+ waves in layer 2/3 and layer 5 rat neocortical pyramidal neurons.
Topics: Action Potentials; Animals; Calcium; Carbachol; Cholinergic Agonists; Cycloleucine; Dendrites; Glycine; Heparin; In Vitro Techniques; Intracellular Membranes; Neocortex; Osmolar Concentration; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Ryanodine; Synapses; Tissue Distribution | 2003 |
Glutamate receptors regulate Na/K-ATPase in cerebellum neurons.
Topics: Animals; Cells, Cultured; Cerebellum; Cycloleucine; Glutamic Acid; Homeostasis; N-Methylaspartate; Neurons; Neurotoxins; Reactive Oxygen Species; Receptors, Glutamate; Sodium-Potassium-Exchanging ATPase | 2003 |
The role of ionotropic receptors of glutaminic acid in cardiovascular system. A. The influence of ionotropic receptor NMDA agonist - 1R,3R-ACPD and antagonist - DL-AP7 on the systemic pressure in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Chlorisondamine; Cycloleucine; Dose-Response Relationship, Drug; Heart Rate; Injections, Intravenous; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2003 |
Dual modulation of gabaergic transmission by metabotropic glutamate receptors in rat ventral tegmental area.
Topics: Anesthetics, Local; Animals; Bicuculline; Cycloleucine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Electrophysiology; Enkephalins; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Leucine; Male; Membrane Potentials; Methoxyhydroxyphenylglycol; Neural Conduction; Neural Inhibition; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrodotoxin; Ventral Tegmental Area | 2003 |
Endogenous zinc as a retinal neuromodulator: evidence from the skate (Raja erinacea).
Topics: Aminobutyrates; Animals; Cells, Cultured; Cycloleucine; Dose-Response Relationship, Drug; Drug Interactions; Electroretinography; Excitatory Amino Acid Agonists; GABA Antagonists; Histidine; Kainic Acid; Membrane Potentials; Neuroprotective Agents; Patch-Clamp Techniques; Picrotoxin; Retina; Skates, Fish; Zinc | 2003 |
Enhancement of low-voltage-activated calcium currents by group II metabotropic glutamate receptors in rat retinal ganglion cells.
Topics: Animals; Calcium; Calcium Channels; Cholera Toxin; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Genistein; GTP-Binding Proteins; Kinetics; Male; Membrane Potentials; Neuroprotective Agents; Patch-Clamp Techniques; Pertussis Toxin; Proline; Rats; Rats, Inbred Strains; Receptors, Metabotropic Glutamate; Retinal Ganglion Cells | 2003 |
Expression of group I metabotropic glutamate receptors in rat hippocampal cells in culture and their characterization by intracellular calcium ion dynamics.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Cycloleucine; Hippocampus; Intracellular Fluid; N-Methylaspartate; Rats; Rats, Wistar; Receptors, AMPA | 2003 |
Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor.
Topics: Biological Transport; Blood-Brain Barrier; Blotting, Western; Brain; Calcium; Cells, Cultured; Cycloleucine; Dizocilpine Maleate; Endothelial Cells; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Neuroprotective Agents; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
Hydroxyl radicals release in rat striatum involves metabotropic glutamate receptors.
Topics: Analysis of Variance; Animals; Corpus Striatum; Cycloleucine; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hydroxyl Radical; Male; Methoxyhydroxyphenylglycol; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Time Factors | 2003 |
Functional synaptic contacts by intranuclear axon collaterals of thalamic relay neurons.
Topics: Animals; Axons; Cats; Cells, Cultured; Cycloleucine; Excitatory Postsynaptic Potentials; Feedback, Physiological; Geniculate Bodies; Interneurons; Intralaminar Thalamic Nuclei; Neural Inhibition; Neural Pathways; Neurons; Synapses | 2003 |
Effects of a selective metabotropic glutamate receptor agonist on the micturition reflex pathway in urethane-anesthetized rats.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Cycloleucine; Electric Stimulation; Electromyography; Injections, Intravenous; Injections, Spinal; Male; Muscle Contraction; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Reflex; Signal Transduction; Urethane; Urinary Bladder; Urination | 2003 |
Nicotine recruits a local glutamatergic circuit to excite septohippocampal GABAergic neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Acyclovir; Animals; Animals, Newborn; Atropine; Bicuculline; Bungarotoxins; Carrier Proteins; Cell Count; Choline; Chromones; Cycloleucine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Electric Conductivity; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Hippocampus; Immunohistochemistry; In Vitro Techniques; Male; Membrane Potentials; Membrane Transport Proteins; Microscopy, Electron; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Parvalbumins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Resorcinols; Septum of Brain; Synapses; Tetrodotoxin; Tubocurarine; Valine; Vesicular Glutamate Transport Protein 2; Vesicular Transport Proteins | 2003 |
Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes.
Topics: Animals; Astrocytes; Calcium; Calcium Signaling; Cell Line; Cells, Cultured; Coculture Techniques; Cycloleucine; Cytosol; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Epithelial Cells; Glutamic Acid; Green Fluorescent Proteins; Humans; Indomethacin; Luminescent Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Patch-Clamp Techniques; Prostaglandins; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Transfection; Valine; Xanthones | 2003 |
Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats.
Topics: Animals; Association Learning; Avoidance Learning; Blotting, Western; Corticosterone; Cycloleucine; Female; Hippocampus; Hydrolysis; Lactation; Male; Phosphatidylinositol Phosphates; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2003 |
Expression and functional properties of group I metabotropic glutamate receptors in bovine chromaffin cells.
Topics: Adrenal Medulla; Alanine; Animals; Calcium; Calcium Channels; Calcium Signaling; Cattle; Cells, Cultured; Chromaffin Cells; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Fluid; Inositol 1,4,5-Trisphosphate; Membrane Potentials; Methoxyhydroxyphenylglycol; Nicotine; Norepinephrine; Reaction Time; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, Nicotinic | 2004 |
NMDA receptors in nucleus tractus solitarii are linked to soluble guanylate cyclase.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminoquinolines; Animals; Baroreflex; Biotransformation; Blood Pressure; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Guanylate Cyclase; In Vitro Techniques; Male; Microinjections; N-Methylaspartate; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Stereotaxic Techniques | 2004 |
NMDA receptor antagonism blocks the cardiovascular responses to microinjection of trans-ACPD into the NTS of awake rats.
Topics: Animals; Blood Pressure; Cardiovascular System; Cycloleucine; Excitatory Amino Acid Antagonists; Heart Rate; Male; Microinjections; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Wakefulness | 2004 |
Role of intracellular calcium stores on the effect of metabotropic glutamate receptors on phosphorylation of glial fibrillary acidic protein in hippocampal slices from immature rats.
Topics: Aging; Animals; Calcium; Cycloleucine; Glial Fibrillary Acidic Protein; Hippocampus; In Vitro Techniques; Neurotoxins; Phosphates; Phosphorylation; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 2004 |
Activation of metabotropic glutamate receptors inhibits high-voltage-gated calcium channel currents of chicken nucleus magnocellularis neurons.
Topics: Animals; Barium; Calcium Channel Blockers; Calcium Channels; Chick Embryo; Cochlear Nucleus; Cycloleucine; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Receptors, Metabotropic Glutamate | 2005 |
Comparison of metabotropic glutamate receptor responses at segmental and descending inputs to motoneurons in neonatal rat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Benzoates; Brain-Derived Neurotrophic Factor; Cycloleucine; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Membrane Potentials; Motor Neurons; Neurotrophin 3; Patch-Clamp Techniques; Phosphinic Acids; Rats; Receptors, Metabotropic Glutamate; Spinal Cord; Spinal Nerve Roots | 2005 |
Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arterioles; Astrocytes; Boron Compounds; Calcium Channels; Calcium Signaling; Cerebral Cortex; Cerebrovascular Circulation; Cycloleucine; Electric Stimulation; Hyperemia; In Vitro Techniques; Indans; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Microscopy, Video; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neurons; Nifedipine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Metabotropic Glutamate; Sodium Channel Blockers; Sodium Channels; Synaptic Transmission; Tetrodotoxin | 2004 |
Effects of metabotropic glutamate receptor stimulation on blood-brain barrier permeability during focal cerebral ischemia.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Capillary Permeability; Cycloleucine; Male; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 2004 |
Ca2+-dependent induction of intracellular Ca2+ oscillation in hippocampal astrocytes during metabotropic glutamate receptor activation.
Topics: Animals; Astrocytes; Calcium; Calcium Signaling; Cells, Cultured; Cycloleucine; Female; Hippocampus; Intracellular Fluid; Pregnancy; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 2005 |
Immunocytochemical and pharmacological characterization of metabotropic glutamate receptors of the vestibular end organs in the frog.
Topics: Animals; Blotting, Western; Brain; Cycloleucine; Electrophysiology; Glutamic Acid; Glycine; Hair Cells, Auditory; Immunohistochemistry; Neurons, Afferent; Neuroprotective Agents; Neurotransmitter Agents; Rana temporaria; Rats; Receptors, Metabotropic Glutamate; Semicircular Canals; Vestibular Nerve | 2005 |
Effects of glutamate transporter and receptor ligands on neuronal glutamate uptake.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ligands; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Oxepins; Rats; Rats, Wistar; Receptors, Glutamate; Tritium; Valine | 2005 |
Novel alternative splicing predicts a truncated isoform of the NMDA receptor subunit 1 (NR1) in embryonic rat brain.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Brain; Brain Chemistry; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cloning, Molecular; Cycloleucine; Female; In Situ Hybridization; Mesencephalon; Molecular Sequence Data; Pregnancy; Rats; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Long-term modulation of electrical synapses in the mammalian thalamus.
Topics: Action Potentials; Animals; Cycloleucine; Electric Conductivity; Electric Stimulation; Excitatory Postsynaptic Potentials; Gap Junctions; Glycine; In Vitro Techniques; Intralaminar Thalamic Nuclei; Membrane Potentials; Neocortex; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synapses | 2005 |
Neuronal basis of the slow (<1 Hz) oscillation in neurons of the nucleus reticularis thalami in vitro.
Topics: Action Potentials; Animals; Apamin; Cadmium; Cats; Computer Simulation; Cycloleucine; Dose-Response Relationship, Radiation; Drug Interactions; Electric Capacitance; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; In Vitro Techniques; Intralaminar Thalamic Nuclei; Models, Neurological; Neural Pathways; Neurons; Neuroprotective Agents; Nickel; Organophosphorus Compounds; Periodicity; Pyridazines; Pyrimidines; Sodium Channel Blockers; Tetrodotoxin; Time Factors | 2006 |
Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in mice.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Nociceptors; Pain; Receptors, Glutamate; Spinal Cord | 2006 |
Nucleus- and species-specific properties of the slow (<1 Hz) sleep oscillation in thalamocortical neurons.
Topics: Action Potentials; Animals; Benzoates; Cats; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Mice; Mice, Inbred C57BL; Neurons; Periodicity; Rats; Rats, Wistar; Sleep Stages; Species Specificity; Thalamic Nuclei | 2006 |
Mechanisms of glutamate receptor induced proliferation of astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Cell Count; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Cycloleucine; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycerophospholipids; Glycine; Indoles; Maleimides; Methoxyhydroxyphenylglycol; Phospholipase D; Pyridines; Rats; Rats, Wistar; Receptors, Glutamate; Tritium | 2006 |
Involvement of hippocampal metabotropic glutamate receptors in radial maze performance.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Injections, Intraventricular; Male; Maze Learning; Memory; Microinjections; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Spatial Behavior | 2007 |
The role of defensins in the excitability of the peripheral vestibular system in the frog: evidence for the presence of communication between the immune and nervous systems.
Topics: Acetylcholine; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha-Defensins; Animals; Atropine; Cholinergic Antagonists; Cycloleucine; Defensins; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Immune System; In Vitro Techniques; Inflammation; Kainic Acid; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neuroimmunomodulation; Neurons, Afferent; Rabbits; Rana temporaria; Receptors, Cholinergic; Receptors, Glutamate; Receptors, Opioid; Semicircular Canals; Synaptic Transmission; Vestibule, Labyrinth | 2007 |
Glutamate and its metabotropic receptor in Drosophila clock neuron circuits.
Topics: Animals; Animals, Genetically Modified; Behavior, Animal; Brain; Calcium; Cycloleucine; Dose-Response Relationship, Drug; Drosophila; Drosophila Proteins; Gene Expression Regulation; Glutamic Acid; Larva; Motor Activity; Nerve Net; Neurons; Neuroprotective Agents; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Effect of exogenous glutamate and N-Methyl-D-aspartic acid on spontaneous activity of isolated human ureter.
Topics: Adult; Aged; Cycloleucine; Female; Glutamic Acid; Humans; In Vitro Techniques; Kainic Acid; Male; Middle Aged; Muscle, Smooth; N-Methylaspartate; Ureter | 2007 |
Acute treatment with 17beta-estradiol attenuates astrocyte-astrocyte and astrocyte-neuron communication.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Calcium; Cell Communication; Cells, Cultured; Cycloleucine; Electric Conductivity; Estradiol; Intracellular Membranes; Male; Neurons; Osmolar Concentration; Physical Stimulation; Potassium Chloride; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2007 |
Estrogen evokes a rapid effect on intracellular calcium in neurons characterized by calcium oscillations in the arcuate nucleus.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Calcium; Calcium Channels; Calcium Signaling; Cyclic AMP-Dependent Protein Kinases; Cycloleucine; Estrogens; Female; Fura-2; In Vitro Techniques; Mice; Neurons; Receptors, Metabotropic Glutamate; Ryanodine; Sarcoplasmic Reticulum; Type C Phospholipases | 2007 |
The glutamate uptake system in presynaptic vesicles: further characterization of structural requirements for inhibitors and substrates.
Topics: Animals; Cattle; Cycloleucine; Glutamic Acid; Models, Molecular; Protein Conformation; Receptors, Glutamate; Synaptic Vesicles | 2008 |
Dendritic properties of turtle pyramidal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain; Calcium; Cycloleucine; Dendrites; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Patch-Clamp Techniques; Pyramidal Cells; Sodium; Turtles | 2008 |
Tone-dependent vascular responses to astrocyte-derived signals.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arterioles; Astrocytes; Calcium; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; In Vitro Techniques; Paracrine Communication; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2008 |
Dynamic metabotropic control of intrinsic firing in cerebellar unipolar brush cells.
Topics: Action Potentials; Amino Acids; Animals; Barium; Bee Venoms; Calbindin 2; Cerebellum; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Interneurons; Male; Mice; Neural Inhibition; Potassium Channel Blockers; Receptors, Metabotropic Glutamate; S100 Calcium Binding Protein G; Xanthenes | 2008 |
Involvement of Group II mGluRs in mossy fiber LTD.
Topics: Amino Acids; Amino Acids, Dicarboxylic; Animals; Cycloleucine; Cyclopropanes; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission; Xanthenes | 2009 |
Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction.
Topics: Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Cycloleucine; Dose-Response Relationship, Drug; Drosophila; Electrophysiology; Excitatory Postsynaptic Potentials; Glutamates; Kainic Acid; Larva; Neuromuscular Junction; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2009 |
A peripheral neuroimmune link: glutamate agonists upregulate NMDA NR1 receptor mRNA and protein, vimentin, TNF-alpha, and RANTES in cultured human synoviocytes.
Topics: Animals; Arthritis; CD11b Antigen; Cell Line, Tumor; Chemokine CCL5; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; N-Methylaspartate; Neurogenic Inflammation; Neuroimmunomodulation; Protein Kinase C; Rats; Receptors, Complement 3d; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sarcoma, Synovial; Synovial Membrane; Synovitis; Tumor Necrosis Factor-alpha; Up-Regulation; Vimentin | 2010 |
Evaluation of cannabinoid receptor 2 and metabotropic glutamate receptor 1 functional responses using a cell impedance-based technology.
Topics: Analgesics; Animals; Benzimidazoles; Biological Assay; Calcium; Cannabinoids; CHO Cells; Chromones; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Cycloleucine; Electric Impedance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Indoles; Naphthalenes; Neuroprotective Agents; Quinolines; Quisqualic Acid; Receptor, Cannabinoid, CB2; Receptors, Metabotropic Glutamate; Resorcinols; Signal Transduction; Thiazoles | 2010 |
[The protective effect of puerarin on cultured rat cerebral cortical astrocytes].
Topics: Animals; Astrocytes; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cycloleucine; Drug Antagonism; Glucose; Glutamic Acid; Isoflavones; Neuroprotective Agents; Rats; Rats, Wistar | 2001 |
Quantal amplitude at the cone ribbon synapse can be adjusted by changes in cytosolic glutamate.
Topics: Ambystoma; Animals; Cycloleucine; Cytosol; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Exocytosis; Glutamic Acid; Macrolides; Receptors, Glutamate; Retinal Cone Photoreceptor Cells; Stochastic Processes; Synapses; Synaptic Transmission; Synaptic Vesicles; Vision, Ocular | 2011 |
Astrocyte inositol triphosphate receptor type 2 and cytosolic phospholipase A2 alpha regulate arteriole responses in mouse neocortical brain slices.
Topics: Animals; Arterioles; Astrocytes; Brain; Calcium Signaling; Cycloleucine; Enzyme Activation; Female; Gene Expression Regulation; Group IV Phospholipases A2; Inositol 1,4,5-Trisphosphate Receptors; Male; Mice; Mice, Knockout; Nitric Oxide Synthase Type I; Receptors, Metabotropic Glutamate; Signal Transduction | 2012 |
In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Astrocytes; Calcium; Cycloleucine; Dextrans; Egtazic Acid; Electric Stimulation; Female; Fluorescein-5-isothiocyanate; Hypercalcemia; Inositol 1,4,5-Trisphosphate Receptors; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Neurons; Neuroprotective Agents; Signal Transduction; Time Factors; Vasodilation | 2013 |
Activation of lateral hypothalamic mGlu1 and mGlu5 receptors elicits feeding in rats.
Topics: Animals; Benzimidazoles; Benzopyrans; Cycloleucine; Dose-Response Relationship, Drug; Eating; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hypothalamus; Male; Phenylacetates; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Thiazoles; Time Factors | 2014 |
[Modulation of GABA- and kainate-activated currents by metabotropic receptors in isolated rat cortical neurons].
Topics: Animals; Baclofen; Cycloleucine; Excitatory Amino Acid Agonists; Female; GABA Antagonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Kainic Acid; Male; Neuroprotective Agents; Phosphinic Acids; Propanolamines; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-B; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2014 |
Spinal D1-like dopamine receptors modulate NMDA receptor-induced hyperexcitability and NR1 subunit phosphorylation at serine 889.
Topics: Animals; Cycloleucine; Evoked Potentials; Male; Nerve Fibers, Unmyelinated; Neuralgia; Neurons; Phosphorylation; Protein Subunits; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Serine; Spinal Cord; Spinal Cord Dorsal Horn | 2016 |
The Effect of Glutamate Receptor Agonists on Mouse Retinal Astrocyte [Ca(2+)]i.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Calcium; Cycloleucine; Excitatory Amino Acid Agonists; Fura-2; Methoxyhydroxyphenylglycol; Mice, Inbred C57BL; N-Methylaspartate; Receptors, Glutamate; Retina | 2016 |