1-O-Acetyllycorine and narciclasine

1-O-Acetyllycorine has been researched along with narciclasine* in 1 studies

Other Studies

1 other study(ies) available for 1-O-Acetyllycorine and narciclasine

Article	Year
Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids. Bioorganic & medicinal chemistry letters, 2009, Jun-15, Volume: 19, Issue:12 A library of natural and semi-synthetic Amaryllidaceae alkaloids was screened for cytochrome P450 3A4 (CYP3A4) inhibitory activity. Of the crinane, lycorane and galanthamine representatives examined two semi-synthetic silylated lycorane analogues, accessed via a chemoselective silylation strategy from lycorine, and the natural compound narciclasine exhibited low micromolar activities. Important pharmacological features uncovered include the lack of CYP3A4 inhibitory activity seen for galanthamine and the selective activity that is seen with narciclasine over pancratistatin. Topics: Amaryllidaceae Alkaloids; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Evaluation, Preclinical; Enzyme Inhibitors; Galantamine; Humans; Isoquinolines; Phenanthridines; Small Molecule Libraries	2009

Article

Year

Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids.

Bioorganic & medicinal chemistry letters, 2009, Jun-15, Volume: 19, Issue:12

A library of natural and semi-synthetic Amaryllidaceae alkaloids was screened for cytochrome P450 3A4 (CYP3A4) inhibitory activity. Of the crinane, lycorane and galanthamine representatives examined two semi-synthetic silylated lycorane analogues, accessed via a chemoselective silylation strategy from lycorine, and the natural compound narciclasine exhibited low micromolar activities. Important pharmacological features uncovered include the lack of CYP3A4 inhibitory activity seen for galanthamine and the selective activity that is seen with narciclasine over pancratistatin.

Topics: Amaryllidaceae Alkaloids; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Evaluation, Preclinical; Enzyme Inhibitors; Galantamine; Humans; Isoquinolines; Phenanthridines; Small Molecule Libraries

2009