Page last updated: 2024-09-03

1,9-dimethylmethylene blue and methylene blue

1,9-dimethylmethylene blue has been researched along with methylene blue in 79 studies

Compound Research Comparison

Studies (1,9-dimethylmethylene blue)	Trials (1,9-dimethylmethylene blue)	Recent Studies (post-2010) (1,9-dimethylmethylene blue)	Studies (methylene blue)	Trials (methylene blue)	Recent Studies (post-2010) (methylene blue)
81	1	6	11,067	394	4,258

Protein Interaction Comparison

Protein	Taxonomy	methylene blue (IC50)
Chain E, Fibrin beta chain	Homo sapiens (human)	9.253
integrase, partial	Human immunodeficiency virus 1	1.958
lens epithelium-derived growth factor p75	Homo sapiens (human)	1.958
Apoptotic peptidase activating factor 1	Homo sapiens (human)	15.5
neutrophil cytosol factor 1	Homo sapiens (human)	0.39
caspase-9 isoform alpha precursor	Homo sapiens (human)	17
caspase-3 isoform a preproprotein	Homo sapiens (human)	17
Glutathione reductase	Plasmodium falciparum 3D7	6.4
Amyloid-beta precursor protein	Homo sapiens (human)	0.5
Microtubule-associated protein tau	Homo sapiens (human)	2.2333
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	0.5
Amine oxidase [flavin-containing] A	Homo sapiens (human)	0.07
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	0.5
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	0.5

Research

Studies (79)

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (26.58)	18.7374
1990's	31 (39.24)	18.2507
2000's	17 (21.52)	29.6817
2010's	10 (12.66)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dey, P; McDonnell, J; Moore, VL; Saphos, CA	1
Baici, A; Fehr, K; Hofer, HO; Hörler, D; Moser, B; Wagenhäuser, FJ	1
Berlinghieri, MC; De Sarro, GB; Focà, A; Liberto, MC; Matera, G	1
Baragi, VM; Jordan, H; Renkiewicz, RR	1
de Jong, JG; Liebrand-van Sambeek, R; Wevers, RA	1
Kéry, V; Orlovská, M; Risko, M; Stancíková, M; Zlnay, D	1
de Jong, JG; Hasselman, JJ; Vader, HL; van Landeghem, AA; Wevers, RA	1
Mandal, N; Pal, MK	1
Goldberg, RL; Kolibas, LM	1
Ghosh, TC; Pal, MK	1
Makovitzky, J	2
Holczinger, L; Kremmer, T; Pokorny, E	1
Draper, KA; Dutton, CM; Neglia, JP; Ridnour, MD; Whitley, CB	1
de Jong, JG; Laarakkers, C; Poorthuis, BJ; Wevers, RA	1
Brown, PA; Draper, KA; Dutton, CM; France, LA; Severson, SL; Whitley, CB	1
Das, S; Ghosh, JK; Pal, MK	1
Hanschke, M; Müller, G	2
Menage, J; Roberts, S; Urban, JP	1
Ghosh, P; Melrose, J	1
Hendriks, T; Klompmakers, AA	1
Plaas, AH; Sandy, JD	1
Barrett, AJ; Buttle, DJ; Farndale, RW	1
Catassi, C; Chiandetti, L; Coppa, GV; Dall'Amico, R; Felici, L; Naia, S; Panin, G; Zachello, F	1
Templeton, DM	1
Chandrasekhar, S; Esterman, MA; Hoffman, HA	1
Keler, T; Nowotny, A	1
Adams, ME; Ho, YA; Sabiston, P	1
Bozsóky, S; László, E; Makovitzky, J	1
Barrett, AJ; Farndale, RW; Sayers, CA	1
Nagase, H; Woessner, JF	1
Barreca, G; Berlinghieri, MC; Focà, A; Matera, G	1
Buttle, DJ; Handley, CJ	1
Coll, R; Conte, A; Grases, F; Llompart, I; March, JG	1
van de Lest, CH; van Kuppevelt, TH; Veerkamp, JH; Versteeg, EM	1
Akhtar, N; Botchway, S; Pennock, CA; Stone, JE	1
de Jong, JG; Heijs, WM; Wevers, RA	1
Kawamura, K; Miyazawa, K; Moriyama, M; Nakajima, C; Suzuki, K; Tsugawa, R	1
Mitsuhashi, H; Naruse, T; Ono, K; Tsukada, Y; Yano, S	1
Bertone, AL; McClain, H; Palmer, JL	1
Elliott, RJ; Sloan, R	1
Bader, DL; Enobakhare, BO; Lee, DA	1
Dieppe, PA; Groves, PJ; Shellis, RP	1
Iwasa, S; Iwata, S; Kokuryu, M; Kondo, N; Noma, A; Orii, T; Sasaki, T; Sukegawa, K; Yamasita, S	1
Burrow, SM; Phoenix, DA; Rice, L; Wainwright, M; Waring, J	1
Cincotta, L; Foley, JW; Robinette, D; Skripchenko, A; Wagner, SJ	1
Cincotta, L; Mallory, DA; Robinette, D; Skripchenko, A; Wagner, SJ	1
Embery, G; Hall, RC; Hughes Wassell, DT; Kamada, A; Okazaki, J; Waddington, RJ	1
Bashir, A; Burstein, D; Gray, ML; Hartke, J	1
Mohammad, T; Morrison, H	1
Abe, H; Gomez, C; Hirayama, J; Ikebuchi, K; Ikeda, H; Macdonald, VW; Sekiguchi, S; Wagner, SJ	1
Bank, RA; Barneveld, A; Brama, PA; Karssenberg, D; Tekoppele, JM; van Weeren, PR	1
Akçay, T; Konukoğlu, D	1
Cincotta, L; Foley, J; Hirayama, J; Mallory, DA; Robinette, D; Skripchenko, A; Wagner, SJ	1
Fujinaga, T; Okumura, M	1
Bank, RA; Barneveld, A; Brama, PA; Tekoppele, JM; van Weeren, PR	1
Anderson, CC; Cook, JL; Kreeger, JM; Tomlinson, JL	1
Skripchenko, AA; Wagner, SJ	1
Abe, H; Hirayama, J; Ikebuchi, K; Ikeda, H; Wagner, SJ	1
Chuang, CK; Chung, SF; Lin, SP	1
Abe, H; Hirayama, J; Ikebuchi, K; Ikeda, H; Kamo, N	1
Howard, RD; McIlwraith, CW; Takafuji, VA	1
Besselink, GA; Blokker, DE; Brand, A; De Korte, D; Korsten, HG; Lagerberg, JW; Van Engelenburg, FA; Verhoeven, AJ	1
Hurtig, MB; Keates, RA; Oke, SL; Wright, JR	1
Hurtig, MB; Keates, RA; Lumsden, JH; Oke, SL; Wright, JR	1
O'Neill, J; Wainwright, M; Wilson, M	1
Appel, TR; Linke, RP; Makovitzky, J; Richter, S	1
Baccarin, RY; de Lima, CR; Michelacci, YM	1
Bansal, PN; Entezari, V; Grinstaff, MW; Joshi, NS; Snyder, BD	1
Alonso-Fernández, JR; Colón, C; Fidalgo, J	1
Agut, M; Dai, T; Hamblin, MR; Nonell, S; Ragàs, X; Tegos, GP	1
Ao, YF; Cui, GQ; Deng, M; Hu, YL; Ju, XD; Wang, JQ; Yu, CL; Yu, JK	1
Balakrishnan, P; Cho, HJ; Chung, CW; Chung, KD; Hwang, HD; Kang, DH; Kang, JY; Kim, DD; Yoon, IS	1
Driscoll, N; Duesterdieck-Zellmer, KF; Ott, JF	1
Davies, NM; Fu, G; Gong, Y; Guo, J; Hong, J; Li, P; Li, Z; Lu, X; Zhang, H; Zhao, T	1
Levenston, ME; Zheng, CH	1
Delport, A; Harvey, BH; Petzer, A; Petzer, JP	1

Reviews

1 review(s) available for 1,9-dimethylmethylene blue and methylene blue

Article	Year
The use of dimethylmethylene blue for virus photoinactivation of red cell suspensions. Developments in biologicals, 2000, Volume: 102 Topics: Animals; Antiviral Agents; Biological Products; Erythrocytes; Humans; Methylene Blue; Photosensitizing Agents; Viruses	2000

Trials

1 trial(s) available for 1,9-dimethylmethylene blue and methylene blue

Article	Year
Mass screening test for mucopolysaccharidoses using the 1,9-dimethylmethylene blue method: positive interference from paper diapers. Clinica chimica acta; international journal of clinical chemistry, 1997, Aug-29, Volume: 264, Issue:2 Topics: Glycosaminoglycans; Humans; Infant; Infant Care; Mass Screening; Methylene Blue; Mucopolysaccharidoses; Paper; Pilot Projects	1997

Other Studies

77 other study(ies) available for 1,9-dimethylmethylene blue and methylene blue

Article	Year
Studies on the quantification of proteoglycans by the dimethylmethylene blue dye-binding method. Specificity, quantitation in synovial lavage fluid, and automation. Connective tissue research, 1992, Volume: 28, Issue:4 Topics: Animals; Autoanalysis; Coloring Agents; Deoxyribonucleases; DNA; False Negative Reactions; Glycosaminoglycans; Hyaluronic Acid; Hyaluronoglucosaminidase; Methylene Blue; Proteoglycans; Quality Control; Rabbits; Ribonucleases; RNA; Synovial Fluid; Therapeutic Irrigation	1992
Analysis of glycosaminoglycans in human serum after oral administration of chondroitin sulfate. Rheumatology international, 1992, Volume: 12, Issue:3 Topics: Administration, Oral; Arthritis, Rheumatoid; Artifacts; Chondroitin Sulfates; Digestive System; Glycosaminoglycans; Humans; Methylene Blue; Osteoarthritis	1992
Teicoplanin reduces in-vitro reactivity and murine lethality of Salmonella minnesota R595 lipopolysaccharide. The Journal of antimicrobial chemotherapy, 1992, Volume: 29, Issue:4 Topics: Animals; Anti-Bacterial Agents; Galactosamine; Glycopeptides; Limulus Test; Lipopolysaccharides; Male; Methylene Blue; Mice; Mice, Inbred C57BL; Polymyxin B; Salmonella; Teicoplanin	1992
A protocol for rapid screening of proteoglycan-degrading metalloproteinase inhibitors. Journal of pharmacological and toxicological methods, 1992, Volume: 27, Issue:2 Topics: Acrylic Resins; Animals; Cells, Cultured; Data Interpretation, Statistical; Enzyme Inhibitors; Metalloendopeptidases; Methylene Blue; Proteoglycans; Rabbits; Time Factors	1992
Measuring urinary glycosaminoglycans in the presence of protein: an improved screening procedure for mucopolysaccharidoses based on dimethylmethylene blue. Clinical chemistry, 1992, Volume: 38, Issue:6 Topics: Colorimetry; Coloring Agents; Drug Stability; Glycosaminoglycans; Humans; Methylene Blue; Mucopolysaccharidoses; Proteinuria; Reference Values	1992
Urinary glycosaminoglycan excretion in rheumatic diseases. Clinical chemistry, 1992, Volume: 38, Issue:6 Topics: Adolescent; Adult; Aged; Alcian Blue; Arthritis, Rheumatoid; Glycosaminoglycans; Humans; Methylene Blue; Middle Aged; Osteoarthritis; Rheumatic Diseases; Spectrophotometry; Spondylitis, Ankylosing	1992
The spot test is not a reliable screening procedure for mucopolysaccharidoses. Clinical chemistry, 1991, Volume: 37, Issue:4 Topics: Azure Stains; False Negative Reactions; False Positive Reactions; Glycosaminoglycans; Humans; Methylene Blue; Mucopolysaccharidoses; Reagent Strips; Reproducibility of Results	1991
Induction of metachromasia and circular dichroism in the dye 1,9-dimethyl methylene blue by ATP. Indian journal of biochemistry & biophysics, 1990, Volume: 27, Issue:2 Topics: Adenosine Triphosphate; Circular Dichroism; Methylene Blue; Molecular Conformation; Spectrophotometry	1990
An improved method for determining proteoglycans synthesized by chondrocytes in culture. Connective tissue research, 1990, Volume: 24, Issue:3-4 Topics: Animals; Cartilage, Articular; Cells, Cultured; Enzymes; Evaluation Studies as Topic; Glycosaminoglycans; Kinetics; Methylene Blue; Proteoglycans; Solubility; Spectrophotometry	1990
Induction of metachromasia and circular dichroism in the dye 1,9-dimethyl methylene blue by S. aureus wall teichoic acid. Indian journal of biochemistry & biophysics, 1990, Volume: 27, Issue:3 Topics: Circular Dichroism; Methylene Blue; Staphylococcus aureus; Teichoic Acids	1990
The study of original and induced negative charges of human lymphocyte membrane. Acta histochemica. Supplementband, 1987, Volume: 34 Topics: B-Lymphocytes; Cell Membrane; Glycosaminoglycans; Histocytochemistry; Humans; Lymphocytes; Methylene Blue; Microscopy, Polarization; RNA; Sialic Acids; Staining and Labeling; T-Lymphocytes	1987
Permanent metachromatic effect of 1,9-dimethyl-methylene blue on acidic mucopolysaccharides of mastocytes. Acta morphologica Hungarica, 1988, Volume: 36, Issue:3-4 Topics: Animals; Glycosaminoglycans; Hydrogen-Ion Concentration; Mast Cells; Methylene Blue; Mice; Staining and Labeling	1988
Diagnostic test for mucopolysaccharidosis. I. Direct method for quantifying excessive urinary glycosaminoglycan excretion. Clinical chemistry, 1989, Volume: 35, Issue:3 Topics: Bone Marrow Transplantation; Boric Acids; Carbazoles; Cetylpyridinium; Coloring Agents; Female; Glycosaminoglycans; Humans; Infant; Mass Screening; Methylene Blue; Mucopolysaccharidoses; Mucopolysaccharidosis I; Quality Control; Spectrophotometry	1989
Dimethylmethylene blue-based spectrophotometry of glycosaminoglycans in untreated urine: a rapid screening procedure for mucopolysaccharidoses. Clinical chemistry, 1989, Volume: 35, Issue:7 Topics: Adolescent; Adult; Age Factors; Centrifugation; Child; Child, Preschool; Colorimetry; Female; Glycosaminoglycans; Humans; Hydrogen-Ion Concentration; Infant; Male; Methylene Blue; Mucopolysaccharidoses; Statistics as Topic	1989
Diagnostic test for mucopolysaccharidosis. II. Rapid quantification of glycosaminoglycan in urine samples collected on a paper matrix. Clinical chemistry, 1989, Volume: 35, Issue:10 Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Data Interpretation, Statistical; Female; Glycosaminoglycans; Humans; Infant; Infant, Newborn; Male; Mass Screening; Methylene Blue; Mucopolysaccharidoses; Paper	1989
Spectrophotometric and spectrofluorometric titrations of teichoic acid. Indian journal of biochemistry & biophysics, 1989, Volume: 26, Issue:5 Topics: Acridine Orange; Methylene Blue; Spectrometry, Fluorescence; Spectrophotometry; Teichoic Acids	1989
[Indirect spectrophotometric microdetermination of sulfated glycosaminoglycans with dimethylmethylene blue]. Zeitschrift fur medizinische Laboratoriumsdiagnostik, 1989, Volume: 30, Issue:3 Topics: Animals; Glycosaminoglycans; Methylene Blue; Spectrophotometry	1989
Biochemical and structural properties of the cartilage end-plate and its relation to the intervertebral disc. Spine, 1989, Volume: 14, Issue:2 Topics: Adolescent; Adult; Body Water; Cartilage; Chemical Phenomena; Chemistry; Humans; Hydroxyproline; Intervertebral Disc; Lumbosacral Region; Methylene Blue; Proteoglycans; Radiography	1989
The quantitative discrimination of corneal type I, but not skeletal type II, keratan sulfate in glycosaminoglycan mixtures by using a combination of dimethylmethylene blue and endo-beta-D-galactosidase digestion. Analytical biochemistry, 1988, May-01, Volume: 170, Issue:2 Topics: beta-Galactosidase; Chondroitin Sulfate Proteoglycans; Cornea; Electrophoresis, Polyacrylamide Gel; Escherichia; Galactosidases; Glycosaminoglycans; Glycoside Hydrolases; Humans; Intervertebral Disc; Keratan Sulfate; Lumican; Methylene Blue; Pseudomonas; Structure-Activity Relationship	1988
A spectrophotometric microassay for sulfated glycosaminoglycans using a laser densitometer. Analytical biochemistry, 1986, Feb-15, Volume: 153, Issue:1 Topics: Animals; Chondroitin Sulfates; Densitometry; Glycosaminoglycans; Humans; Intestines; Lasers; Methylene Blue; Rabbits; Reference Standards; Spectrophotometry	1986
Age-related changes in the kinetics of release of proteoglycans from normal rabbit cartilage explants. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 1986, Volume: 4, Issue:3 Topics: Age Factors; Animals; Cartilage, Articular; Cell Aggregation; Chondroitin Sulfates; Culture Techniques; Glycosaminoglycans; Half-Life; Hyaluronic Acid; Keratan Sulfate; Kinetics; Knee Joint; Methylene Blue; Proteoglycans; Rabbits; Time Factors	1986
Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochimica et biophysica acta, 1986, Sep-04, Volume: 883, Issue:2 Topics: beta-Galactosidase; Chondroitin Lyases; Glycosaminoglycans; Glycoside Hydrolases; Methylene Blue; Spectrophotometry; Sulfates	1986
Simple spectrophotometric quantification of urinary excretion of glycosaminoglycan sulfates. Clinical chemistry, 1986, Volume: 32, Issue:11 Topics: Adolescent; Adult; Boric Acids; Carbazoles; Child; Child, Preschool; Female; Glycosaminoglycans; Humans; Infant; Male; Methylene Blue; Mucopolysaccharidosis IV; Spectrophotometry; Statistics as Topic	1986
The basis and applicability of the dimethylmethylene blue binding assay for sulfated glycosaminoglycans. Connective tissue research, 1988, Volume: 17, Issue:1 Topics: Animals; Anions; Basement Membrane; Borohydrides; Cations; Cattle; Chondroitin Sulfates; Dermatan Sulfate; Glycosaminoglycans; Hyaluronic Acid; Kidney Glomerulus; Macromolecular Substances; Methylene Blue; Solubility; Spectrophotometry; Sulfuric Acids; Uronic Acids	1988
Microdetermination of proteoglycans and glycosaminoglycans in the presence of guanidine hydrochloride. Analytical biochemistry, 1987, Feb-15, Volume: 161, Issue:1 Topics: Animals; DNA; Glycosaminoglycans; Guanidine; Guanidines; Humans; Methylene Blue; Microchemistry; Proteoglycans	1987
Metachromatic assay for the quantitative determination of bacterial endotoxins. Analytical biochemistry, 1986, Volume: 156, Issue:1 Topics: Chromatography, Ion Exchange; Colorimetry; Endotoxins; Lipopolysaccharides; Methylene Blue; Polymyxin B; Salmonella; Spectrophotometry	1986
Automation of 1,9-dimethylmethylene blue dye-binding assay for sulfated glycosaminoglycans with application to cartilage microcultures. Analytical biochemistry, 1985, Volume: 149, Issue:2 Topics: Animals; Autoanalysis; Cartilage; Cattle; Cells, Cultured; Coloring Agents; Glycosaminoglycans; Methylene Blue; Microchemistry	1985
Topo-optical reactions of the human blood platelet membrane. Histochemistry, 1983, Volume: 79, Issue:2 Topics: Blood Platelets; Carbocyanines; Cell Membrane; Glycoproteins; Histocytochemistry; Humans; Hydrolysis; Methylene Blue; Neuraminidase; Staining and Labeling; Tolonium Chloride	1983
[Components of Ehrlich ascites tumor cell surface]. Acta histochemica. Supplementband, 1984, Volume: 29 Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Membrane; Chemical Precipitation; Methylene Blue; Mice; Microscopy, Polarization; N-Acetylneuraminic Acid; Sialic Acids; Staining and Labeling	1984
A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. Connective tissue research, 1982, Volume: 9, Issue:4 Topics: Animals; Cartilage; Culture Techniques; Glycosaminoglycans; Humans; Methylene Blue; Microchemistry; Papain; Spectrophotometry; Sulfuric Acids	1982
An improved assay for proteases and polysaccharidases employing a cartilage proteoglycan substrate entrapped in polyacrylamide particles. Analytical biochemistry, 1980, Sep-15, Volume: 107, Issue:2 Topics: Acrylamides; Animals; Cartilage; Cattle; Coloring Agents; Glycoside Hydrolases; Methylene Blue; Microspheres; Nose; Peptide Hydrolases; Proteoglycans; Uronic Acids	1980
In vitro effects of novel glycopeptide antibiotics on the reactivity of the lipopolysaccharide (LPS) of S. minnesota R595. The new microbiologica, 1995, Volume: 18, Issue:3 Topics: Analysis of Variance; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Limulus Test; Lipopolysaccharides; Methylene Blue; Salmonella; Spectrophotometry; Structure-Activity Relationship; Teicoplanin	1995
Assay of proteoglycan degradation. Methods in enzymology, 1995, Volume: 248 Topics: Amino Acid Sequence; Electrophoresis, Polyacrylamide Gel; Glycosaminoglycans; Methylene Blue; Molecular Sequence Data; Peptide Fragments; Proteoglycans	1995
Glycosaminoglycans and oxalocalcic urolithiasis. Nephron, 1994, Volume: 68, Issue:4 Topics: Calcium Oxalate; Female; Glycosaminoglycans; Humans; Male; Methylene Blue; Photometry; Urinary Calculi	1994
A spectrophotometric method for the determination of heparan sulfate. Biochimica et biophysica acta, 1994, Nov-11, Volume: 1201, Issue:2 Topics: Glycosaminoglycans; Heparitin Sulfate; Humans; Hydrogen-Ion Concentration; Methylene Blue; Mucopolysaccharidoses; Proteoglycans; Sensitivity and Specificity; Serum Albumin, Bovine; Sodium Chloride; Spectrophotometry	1994
Interaction of 1,9-dimethylmethylene blue with glycosaminoglycans. Annals of clinical biochemistry, 1994, Volume: 31 ( Pt 2) Topics: Drug Storage; Glycosaminoglycans; Mass Spectrometry; Methylene Blue; Spectrophotometry, Ultraviolet	1994
Mucopolysaccharidoses screening: dimethylmethylene blue versus alcian blue. Annals of clinical biochemistry, 1994, Volume: 31 ( Pt 3) Topics: Adolescent; Adult; Alcian Blue; Child; Child, Preschool; Glycosaminoglycans; Humans; Infant; Methylene Blue; Middle Aged; Mucopolysaccharidoses; Sensitivity and Specificity	1994
[Studies on the modified dimethylmethylene-blue (DMB) method for determining glycosaminoglycans (GAG) in urine]. Hinyokika kiyo. Acta urologica Japonica, 1994, Volume: 40, Issue:7 Topics: Adult; Glycosaminoglycans; Humans; Male; Methylene Blue	1994
Urine glycosaminoglycans and heparan sulfate excretions in adult patients with glomerular diseases. Clinical nephrology, 1993, Volume: 39, Issue:5 Topics: Adult; Enzyme-Linked Immunosorbent Assay; Female; Glomerulonephritis, IGA; Glomerulonephritis, Membranous; Glycosaminoglycans; Heparitin Sulfate; Humans; Male; Methylene Blue; Nephrosis, Lipoid; Spectrophotometry; Urinalysis	1993
Assessment of glycosaminoglycan concentration in equine synovial fluid as a marker of joint disease. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 1995, Volume: 59, Issue:3 Topics: Analysis of Variance; Animals; Biomarkers; Colorimetry; Glycosaminoglycans; Horse Diseases; Horses; Hyaluronic Acid; Joint Diseases; Methylene Blue; Synovial Fluid	1995
Quantitative measurement of sulphated glycosaminoglycans in urine. Biochemical Society transactions, 1996, Volume: 24, Issue:1 Topics: Chondroitin Sulfates; Coloring Agents; Glycosaminoglycans; Heparitin Sulfate; Humans; Methylene Blue; Reference Values; Sensitivity and Specificity; Spectrophotometry	1996
Quantitative and qualitative analyses of proteoglycans in cartilage extracts by precipitation with 1,9-dimethylmethylene blue. Connective tissue research, 1996, Volume: 33, Issue:4 Topics: Animals; Cartilage, Articular; Chondroitin Sulfates; Coloring Agents; Dogs; Humerus; Methylene Blue; Proteoglycans; Sensitivity and Specificity; Staining and Labeling; Tissue Extracts	1996
Quantification of sulfated glycosaminoglycans in chondrocyte/alginate cultures, by use of 1,9-dimethylmethylene blue. Analytical biochemistry, 1996, Dec-01, Volume: 243, Issue:1 Topics: Alginates; Animals; Bacteriological Techniques; Cartilage; Cattle; Chondroitin Sulfates; Glucuronic Acid; Glycosaminoglycans; Hexuronic Acids; Hydrogen-Ion Concentration; Methylene Blue	1996
Use of polyvinyl alcohol to stabilize binding of sulfated glycosaminoglycans to dimethylmethylene blue. Analytical biochemistry, 1997, Feb-15, Volume: 245, Issue:2 Topics: Calorimetry; Dermatan Sulfate; Detergents; Glycosaminoglycans; Heparin; Hyaluronic Acid; Methylene Blue; Polyvinyl Alcohol; Sensitivity and Specificity; Serum Albumin, Bovine; Urea	1997
Increased cytotoxicity and phototoxicity in the methylene blue series via chromophore methylation. Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 40, Issue:3 Topics: Animals; Antineoplastic Agents; Darkness; Drug Screening Assays, Antitumor; Light; Methylation; Methylene Blue; Mice; Molecular Structure; Photosensitizing Agents; Tumor Cells, Cultured	1997
Factors affecting virus photoinactivation by a series of phenothiazine dyes. Photochemistry and photobiology, 1998, Volume: 67, Issue:3 Topics: Animals; Antiviral Agents; Blood-Borne Pathogens; Chlorocebus aethiops; Coloring Agents; Erythrocytes; Humans; Light; Methylene Blue; Phenothiazines; Photochemistry; Photosensitizing Agents; Vero Cells	1998
Preservation of red cell properties after virucidal phototreatment with dimethylmethylene blue. Transfusion, 1998, Volume: 38, Issue:8 Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Blood Preservation; Diarrhea Viruses, Bovine Viral; Encephalomyocarditis virus; Erythrocytes; Hemolysis; Herpesvirus 1, Suid; Humans; Light; Methylene Blue; Osmotic Fragility; Photosensitizing Agents; Potassium; Vesicular stomatitis Indiana virus; Virus Activation	1998
Adsorption of glycosaminoglycans onto hydroxyapatite using chromatography. Biomaterials, 1999, Volume: 20, Issue:4 Topics: Adsorption; Binding Sites; Biocompatible Materials; Chromatography, Liquid; Durapatite; Glycosaminoglycans; Hydrogen-Ion Concentration; Kinetics; Methylene Blue; Reproducibility of Results	1999
Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI. Magnetic resonance in medicine, 1999, Volume: 41, Issue:5 Topics: Animals; Arthroplasty, Replacement, Knee; Cartilage, Articular; Cattle; Coloring Agents; Contrast Media; Disease Progression; Feasibility Studies; Gadolinium DTPA; Glycosaminoglycans; Humans; Knee Joint; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Methylene Blue; Reproducibility of Results; Sodium	1999
Photonuclease activity of Taylor's blue. Bioorganic & medicinal chemistry letters, 1999, Aug-02, Volume: 9, Issue:15 Topics: Circular Dichroism; DNA; DNA Damage; Intercalating Agents; Methylene Blue; Photosensitizing Agents; Spectrum Analysis	1999
Virus photoinactivation in stroma-free hemoglobin with methylene blue or 1,9-dimethylmethylene blue. Photochemistry and photobiology, 2000, Volume: 71, Issue:1 Topics: Animals; Antiviral Agents; Blood Substitutes; Chlorocebus aethiops; Hemoglobins; Methylene Blue; Vero Cells; Vesicular stomatitis Indiana virus	2000
Topographical mapping of biochemical properties of articular cartilage in the equine fetlock joint. Equine veterinary journal, 2000, Volume: 32, Issue:1 Topics: Amino Acids; Animals; Biomechanical Phenomena; Biopsy; Bisbenzimidazole; Cartilage, Articular; Chromatography, High Pressure Liquid; Collagen; DNA; Extracellular Matrix; Fluorescent Dyes; Forelimb; Glycosaminoglycans; Horses; Hydroxylysine; Joints; Methylene Blue; Water	2000
Glycosaminoglycans excretion in interstitial cystitis. International urology and nephrology, 1999, Volume: 31, Issue:4 Topics: Biomarkers; Creatinine; Cystitis, Interstitial; Female; Glycosaminoglycans; Humans; Male; Methylene Blue; Middle Aged; Urothelium	1999
Evaluation of the role of keratan sulphate as a molecular marker to monitor cartilage metabolism in horses. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine, 2000, Volume: 47, Issue:2 Topics: Animals; Antibodies, Monoclonal; Biomarkers; Cartilage Diseases; Cartilage, Articular; Chondrocytes; Colorimetry; Enzyme-Linked Immunosorbent Assay; Female; Glycosaminoglycans; Horse Diseases; Horses; Insulin-Like Growth Factor I; Interleukin-1; Joint Diseases; Keratan Sulfate; Methylene Blue; Photosensitizing Agents; Statistics, Nonparametric	2000
Functional adaptation of equine articular cartilage: the formation of regional biochemical characteristics up to age one year. Equine veterinary journal, 2000, Volume: 32, Issue:3 Topics: Age Factors; Amino Acids; Animals; Animals, Newborn; Bisbenzimidazole; Cartilage, Articular; Chromatography, High Pressure Liquid; Collagen; DNA; Glycosaminoglycans; Horses; Hydroxylysine; Hydroxyproline; Joints; Methylene Blue; Statistics, Nonparametric; Water	2000
Effects of human recombinant interleukin-1beta on canine articular chondrocytes in three-dimensional culture. American journal of veterinary research, 2000, Volume: 61, Issue:7 Topics: Animals; Cartilage, Articular; Cell Culture Techniques; Chondrocytes; Collagen; Dinoprostone; Dogs; Glycosaminoglycans; Humans; Immunoenzyme Techniques; Immunohistochemistry; Interleukin-1; Matrix Metalloproteinase 3; Methylene Blue; Recombinant Proteins; Statistics, Nonparametric	2000
Inactivation of WBCs in RBC suspensions by photoactive phenothiazine dyes: comparison of dimethylmethylene blue and MB. Transfusion, 2000, Volume: 40, Issue:8 Topics: Coloring Agents; DNA Fragmentation; Erythrocytes; Flow Cytometry; Humans; Leukocytes; Leukocytes, Mononuclear; Light; Methylene Blue; Phenothiazines; Photosensitizing Agents; Propidium; Virus Activation	2000
Involvement of reactive oxygen species in hemoglobin oxidation and virus inactivation by 1,9-dimethylmethylene blue phototreatment. Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:4 Topics: Bacteriophages; Catalase; Free Radical Scavengers; Hemoglobins; Humans; Light; Methylene Blue; Oxidation-Reduction; Reactive Oxygen Species; Superoxide Dismutase	2001
Diagnostic screening for mucopolysaccharidoses by the dimethylmethylene blue method and two dimensional electrophoresis. Zhonghua yi xue za zhi = Chinese medical journal; Free China ed, 2001, Volume: 64, Issue:1 Topics: Adolescent; Adult; Child; Child, Preschool; Electrophoresis; Glycosaminoglycans; Humans; Infant; Methylene Blue; Mucopolysaccharidoses; Sensitivity and Specificity; Spectrophotometry	2001
Comparison of the effects of different antiviral treatments on the antioxidant systems of stroma-free hemoglobin. Photochemistry and photobiology, 2001, Volume: 74, Issue:3 Topics: Antioxidants; Antiviral Agents; Blood-Borne Pathogens; Hemoglobins; HIV; Hot Temperature; Humans; In Vitro Techniques; Methylene Blue; Photobiology; Photosensitizing Agents; Vesicular stomatitis Indiana virus; Viruses	2001
Effects of equine recombinant interleukin-1alpha and interleukin-1beta on proteoglycan metabolism and prostaglandin E2 synthesis in equine articular cartilage explants. American journal of veterinary research, 2002, Volume: 63, Issue:4 Topics: Animals; Cartilage, Articular; Chondrocytes; Dinoprostone; DNA; Horses; In Vitro Techniques; Interleukin-1; Methylene Blue; Proteoglycans; Random Allocation; Recombinant Proteins; Sulfates; Sulfur Radioisotopes	2002
The band III ligand dipyridamole protects human RBCs during photodynamic treatment while extracellular virus inactivation is not affected. Transfusion, 2002, Volume: 42, Issue:6 Topics: Anion Exchange Protein 1, Erythrocyte; Diarrhea Viruses, Bovine Viral; Dipyridamole; Encephalomyocarditis virus; Erythrocyte Membrane; Erythrocytes; Free Radical Scavengers; Hemolysis; Herpesvirus 1, Suid; HIV-1; Humans; Ligands; Methylene Blue; Oxidative Stress; Parvovirus, Canine; Photochemistry; Photochemotherapy; Radiation-Protective Agents; Radiation-Sensitizing Agents; Vesicular stomatitis Indiana virus; Viruses	2002
Development of a solid-phase assay for measurement of sulfated glycosaminoglycan concentrations in equine synovial fluid. American journal of veterinary research, 2003, Volume: 64, Issue:7 Topics: Animals; Densitometry; Glycosaminoglycans; Horse Diseases; Horses; Methylene Blue; Osteoarthritis; Synovial Fluid	2003
Assessment of three variations of the 1,9-dimethylmethylene blue assay for measurement of sulfated glycosaminoglycan concentrations in equine synovial fluid. American journal of veterinary research, 2003, Volume: 64, Issue:7 Topics: Animals; Glycosaminoglycans; Horse Diseases; Horses; Joint Diseases; Joints; Methylene Blue; Reproducibility of Results; Spectrophotometry; Synovial Fluid	2003
Comparative antistreptococcal activity of photobactericidal agents. Journal of chemotherapy (Florence, Italy), 2003, Volume: 15, Issue:4 Topics: In Vitro Techniques; Indoles; Methylene Blue; Organometallic Compounds; Photosensitizing Agents; Protoporphyrins; Streptococcal Infections; Streptococcus sanguis; Tolonium Chloride	2003
Histochemical and topo-optical investigations on tissue-isolated and in vitro amyloid fibrils. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2005, Volume: 12, Issue:3 Topics: Amyloid; Animals; Azo Compounds; Carbohydrate Metabolism; Carbohydrates; Congo Red; Horses; Humans; Immunohistochemistry; In Vitro Techniques; Insulin; Methylene Blue; Myoglobin; Naphthalenes; Organ Specificity; Refractometry; Staining and Labeling; Tolonium Chloride	2005
Reliability of 1,9-dimethylmethylene blue tests in comparison to agarose gel electrophoresis for quantification of urinary glycosaminoglycans. Clinica chimica acta; international journal of clinical chemistry, 2007, Volume: 378, Issue:1-2 Topics: Animals; Creatinine; Densitometry; Dogs; Electrophoresis, Agar Gel; Glycosaminoglycans; Goats; Horses; Methylene Blue; Sheep	2007
Contrast enhanced computed tomography can predict the glycosaminoglycan content and biomechanical properties of articular cartilage. Osteoarthritis and cartilage, 2010, Volume: 18, Issue:2 Topics: Animals; Cartilage, Articular; Cattle; Compressive Strength; Contrast Media; Disease Models, Animal; Glycosaminoglycans; Methylene Blue; Osteoarthritis, Knee; Tomography, X-Ray Computed	2010
Neonatal screening for mucopolysaccharidoses by determination of glycosaminoglycans in the eluate of urine-impregnated paper: preliminary results of an improved DMB-based procedure. Journal of clinical laboratory analysis, 2010, Volume: 24, Issue:3 Topics: Aging; Calibration; Chondroitin Sulfates; Creatinine; Dermatan Sulfate; Glycosaminoglycans; Heparin; Heparinoids; Humans; Hyaluronic Acid; Infant, Newborn; Methylene Blue; Mucopolysaccharidoses; Neonatal Screening; Paper; Reproducibility of Results; Sensitivity and Specificity	2010
Photodynamic inactivation of Acinetobacter baumannii using phenothiazinium dyes: in vitro and in vivo studies. Lasers in surgery and medicine, 2010, Volume: 42, Issue:5 Topics: Acinetobacter baumannii; Acinetobacter Infections; Animals; Coloring Agents; Female; Methylene Blue; Mice; Mice, Inbred BALB C; Photochemotherapy; Photosensitizing Agents; Tolonium Chloride	2010
The protective effect of tetramethylpyrazine on cartilage explants and chondrocytes. Journal of ethnopharmacology, 2010, Nov-11, Volume: 132, Issue:2 Topics: Animals; Apoptosis; Cartilage, Articular; Caspase 3; Cell Survival; Cells, Cultured; Chondrocytes; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glycosaminoglycans; Interleukin-1beta; Matrix Metalloproteinase 3; Membrane Potential, Mitochondrial; Methylene Blue; Proteoglycans; Pyrazines; Rabbits; Reactive Oxygen Species; Tissue Culture Techniques; Tissue Inhibitor of Metalloproteinase-1	2010
Interpenetrating polymer network (IPN) scaffolds of sodium hyaluronate and sodium alginate for chondrocyte culture. Colloids and surfaces. B, Biointerfaces, 2011, Dec-01, Volume: 88, Issue:2 Topics: Alginates; Animals; Calcium Chloride; Cell Differentiation; Cells, Cultured; Chondrocytes; Collagen; Glucuronic Acid; Hexuronic Acids; Hyaluronic Acid; Methylene Blue; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; Tissue Scaffolds	2011
Concentration-dependent effects of tiludronate on equine articular cartilage explants incubated with and without interleukin-1β. American journal of veterinary research, 2012, Volume: 73, Issue:10 Topics: Animals; Apoptosis; Bone Density Conservation Agents; Cartilage, Articular; Chondrocytes; Dinoprostone; Diphosphonates; Dose-Response Relationship, Drug; Down-Regulation; Glycosaminoglycans; Horse Diseases; Horses; Immunoenzyme Techniques; In Situ Nick-End Labeling; In Vitro Techniques; Interleukin-1beta; Interleukin-6; Interleukin-8; Matrix Metalloproteinases; Methylene Blue; Osteoarthritis; Recombinant Proteins	2012
Diabetes results in structural alteration of chondroitin sulfate in the urine. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2013, Volume: 16, Issue:3 Topics: Chondroitin Sulfates; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Electrophoresis, Agar Gel; Female; Heparitin Sulfate; Humans; Male; Methylene Blue; Middle Aged	2013
Fact versus artifact: avoiding erroneous estimates of sulfated glycosaminoglycan content using the dimethylmethylene blue colorimetric assay for tissue-engineered constructs. European cells & materials, 2015, Apr-19, Volume: 29 Topics: Adipose Tissue; Animals; Artifacts; Cartilage; Cattle; Cells, Cultured; Chondrocytes; Colorimetry; Glycosaminoglycans; Humans; Hyaluronic Acid; Hydrogen-Ion Concentration; Menisci, Tibial; Methylene Blue; Nucleic Acids; Reproducibility of Results; Stem Cells; Tissue Engineering	2015
The monoamine oxidase inhibition properties of selected structural analogues of methylene blue. Toxicology and applied pharmacology, 2017, 06-15, Volume: 325 Topics: Benzoxazines; Binding Sites; Dose-Response Relationship, Drug; Humans; Methylene Blue; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neutral Red; Oxazines; Protein Binding; Recombinant Proteins; Risk Assessment; Serotonin Syndrome; Structure-Activity Relationship	2017
[In process]. Mikrobiologiia, 2016, Volume: 85, Issue:4 Topics: Anti-Bacterial Agents; Biofilms; Cell Culture Techniques; Colony Count, Microbial; Gentian Violet; Glass; Gram-Negative Bacteria; Gram-Positive Bacteria; Methylene Blue; Microbial Sensitivity Tests; Plankton; Polytetrafluoroethylene; Staining and Labeling; Tetrazolium Salts	2016