Compounds > 1,7-phenanthroline
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1,7-phenanthroline and ascididemin

1,7-phenanthroline has been researched along with ascididemin in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (68.75)29.6817
2010's5 (31.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bailly, C; Baldeyrou, B; Banaigs, B; Bonnard, I; Dassonneville, L; Lansiaux, A; Mahieu, C; Wattez, N1
Bastide, J; Bayssade, S; Bouteillé, A; Collignon, F; Darro, F; Delfourne, E; Frydman, A; Galaup, C; Kiss, R; Le Corre, L; Lesur, B; Portefaix, P1
Barrows, LR; Biggs, J; Copp, BR; Holden, JA; Matsumoto, SS1
Brun, R; Copp, BR; Kayser, O; Kiderlen, AF1
Bastide, J; Collignon, F; Darro, F; Delfourne, E; Dujols, F; Frydman, A; Kiss, R; Le Corre, L; Lesur, B2
Bastide, J; Darro, F; Delfourne, E; Frydman, A; Kiss, R; Le Corre, L; Merza, J1
Bhattacharya, S; Debnath, B; Gayen, S; Jha, T; Samanta, S1
Dirsch, VM; Estermeier, M; Kirschke, SO; Steffan, B; Vollmar, AM1
Barrows, LR; Marshall, KM1
De Cian, A; De Pauw, E; Delfourne, E; Gabelica, V; Guittat, L; Mergny, JL; Rosu, F1
Vollmar, AM; von Schwarzenberg, K1
Crestey, F; Kristensen, JL; Petersen, IN1
Morvan, D1
Shan, N; Wang, S; Yao, ZJ; Yin, H1
Gao, RR; Hu, XC; Shi, JJ; Shi, S; Wumaier, M; Yao, TM1

Reviews

2 review(s) available for 1,7-phenanthroline and ascididemin

ArticleYear
Biological activities of pyridoacridines.
    Natural product reports, 2004, Volume: 21, Issue:6

    Topics: Acridines; Alkaloids; Antifungal Agents; Antineoplastic Agents; Antiparasitic Agents; Antiviral Agents; DNA; Phenanthrolines; Quinolines

2004
Targeting apoptosis pathways by natural compounds in cancer: marine compounds as lead structures and chemical tools for cancer therapy.
    Cancer letters, 2013, May-28, Volume: 332, Issue:2

    Topics: Alkaloids; Alkanes; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Aquatic Organisms; Biological Products; Bryostatins; Carbamates; Cell Proliferation; Depsipeptides; Dioxoles; Drug Screening Assays, Antitumor; Humans; Lactones; Macrolides; Microtubules; Models, Chemical; Neoplasms; Phenanthrolines; Phenazines; Proteasome Endopeptidase Complex; Pyrones; Pyrroles; Quinolines; Spiro Compounds; Steroids; Tetrahydroisoquinolines; Thiazoles; Trabectedin

2013

Other Studies

14 other study(ies) available for 1,7-phenanthroline and ascididemin

ArticleYear
Inhibition of topoisomerase II by the marine alkaloid ascididemin and induction of apoptosis in leukemia cells.
    Biochemical pharmacology, 2000, Aug-15, Volume: 60, Issue:4

    Topics: Alkaloids; Animals; Apoptosis; DNA Topoisomerases, Type I; HL-60 Cells; Humans; Leukemia; Oceans and Seas; Phenanthrolines; Plankton; Quinolines; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

2000
Synthesis and in vitro antitumor activity of novel ring D analogues of the marine pyridoacridine ascididemin: structure-activity relationship.
    Journal of medicinal chemistry, 2002, Aug-15, Volume: 45, Issue:17

    Topics: Acridines; Alkaloids; Animals; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Mice; Phenanthrolines; Quinolines; Structure-Activity Relationship; Tumor Cells, Cultured

2002
Mechanism of ascididemin-induced cytotoxicity.
    Chemical research in toxicology, 2003, Volume: 16, Issue:2

    Topics: Alkaloids; Animals; Antineoplastic Agents; Antioxidants; Catalase; CHO Cells; Cricetinae; DNA; DNA Damage; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Induction; Glutathione; Heme Oxygenase (Decyclizing); Metals, Heavy; Oxidation-Reduction; Phenanthrolines; Quinolines; Quinones; Reactive Oxygen Species

2003
Antiparasitic activity of marine pyridoacridone alkaloids related to the ascididemins.
    Planta medica, 2003, Volume: 69, Issue:6

    Topics: Acridines; Alkaloids; Animals; Antiprotozoal Agents; Cell Line; Leishmania donovani; Macrophages; Mice; Microbial Sensitivity Tests; Muscle, Skeletal; Myoblasts; Parasitic Sensitivity Tests; Phenanthrolines; Phytotherapy; Plasmodium falciparum; Quinolines; Rats; Structure-Activity Relationship; Trypanosoma; Trypanosoma brucei brucei; Trypanosoma cruzi; Urochordata

2003
Synthesis and in vitro antitumor activity of phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine: structure-activity relationship.
    Journal of medicinal chemistry, 2003, Jul-31, Volume: 46, Issue:16

    Topics: Alkaloids; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Humans; Hydrazones; Phenanthrolines; Quinolines; Structure-Activity Relationship

2003
Synthesis and in vitro antitumor activity of an isomer of the marine pyridoacridine alkaloid ascididemin and related compounds.
    Bioorganic & medicinal chemistry, 2003, Oct-01, Volume: 11, Issue:20

    Topics: Acridines; Alkaloids; Animals; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Isomerism; Marine Biology; Phenanthrolines; Quinolines; Structure-Activity Relationship; Urochordata

2003
QSAR study on some pyridoacridine ascididemin analogues as anti-tumor agents.
    Bioorganic & medicinal chemistry, 2003, Dec-01, Volume: 11, Issue:24

    Topics: Acridines; Alkaloids; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Electrochemistry; Humans; Inhibitory Concentration 50; Phenanthrolines; Quantitative Structure-Activity Relationship; Quinolines

2003
Apoptosis signaling triggered by the marine alkaloid ascididemin is routed via caspase-2 and JNK to mitochondria.
    Oncogene, 2004, Feb-26, Volume: 23, Issue:8

    Topics: Alkaloids; Apoptosis; Caspases; Cell Line, Tumor; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; MAP Kinase Kinase 4; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Phenanthrolines; Quinolines; Reactive Oxygen Species; Signal Transduction; Time Factors; Transfection

2004
Synthesis and in vitro antitumor activity of ring C and D-substituted phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine.
    Bioorganic & medicinal chemistry, 2004, Aug-01, Volume: 12, Issue:15

    Topics: Acridines; Alkaloids; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Phenanthrolines; Quinolines; Structure-Activity Relationship

2004
Ascididemin and meridine stabilise G-quadruplexes and inhibit telomerase in vitro.
    Biochimica et biophysica acta, 2005, Aug-05, Volume: 1724, Issue:3

    Topics: Alkaloids; Dialysis; DNA; G-Quadruplexes; Intercalating Agents; Ligands; Mass Spectrometry; Phenanthrolines; Quinolines; Spectrometry, Fluorescence; Telomerase

2005
Total synthesis of ascididemin via anionic cascade ring closure.
    Chemical communications (Cambridge, England), 2012, Sep-18, Volume: 48, Issue:72

    Topics: Alkaloids; Biological Products; Chemistry Techniques, Synthetic; Phenanthrolines; Quinolines

2012
Functional metabolomics uncovers metabolic alterations associated to severe oxidative stress in MCF7 breast cancer cells exposed to ascididemin.
    Marine drugs, 2013, Oct-11, Volume: 11, Issue:10

    Topics: Alkaloids; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Female; Humans; MCF-7 Cells; Metabolome; Metabolomics; Oxidative Stress; Phenanthrolines; Quinolines

2013
Total synthesis of ascididemin-type alkaloids using alkyne building blocks.
    The Journal of organic chemistry, 2014, Oct-17, Volume: 79, Issue:20

    Topics: Alkaloids; Alkynes; Molecular Structure; Phenanthrolines; Quinolines; Stereoisomerism

2014
G-quadruplex and duplex DNA binding studies of novel Ruthenium(II) complexes containing ascididemin ligands.
    Journal of inorganic biochemistry, 2019, Volume: 196

    Topics: Alkaloids; Coordination Complexes; DNA; Fluorescence Resonance Energy Transfer; G-Quadruplexes; Molecular Docking Simulation; Phenanthrolines; Quinolines; Ruthenium

2019