1,7-phenanthroline has been researched along with antofine in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (21.43) | 29.6817 |
| 2010's | 29 (69.05) | 24.3611 |
| 2020's | 4 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Heo, YH; Lee, SK; Nam, KA | 1 |
| Kim, D; Kim, S; Lee, J; Lee, T; Park, HG | 1 |
| Fan, GJ; Kim, D; Kim, S; Lee, E; Lee, J; Lee, SK; Lee, T | 1 |
| Fürstner, A; Kennedy, JW | 1 |
| Camacho-Davila, A; Herndon, JW | 1 |
| Cheng, M; Fu, Y; Kim, S; Lee, J; Lee, SK; Lee, T; Min, HY | 1 |
| Cho, J; Fu, Y; Kim, D; Kim, S; Lee, J; Lee, T; Lee, YM; Song, Y | 1 |
| Bastow, KF; Chiang, PC; Damu, AG; Lee, KH; Morris-Natschke, SL; Su, CR; Wu, TS | 1 |
| Bastow, KF; Lee, KH; Lin, JC; Liu, YN; Shi, Q; Yang, PC; Yang, SC; Yang, X; Zhao, G | 1 |
| Kim, S; Lee, B; Lee, SK; Min, HY; Song, SH | 1 |
| Bastow, KF; Lee, KH; Shi, Q; Yang, X | 1 |
| Chung, HJ; Kim, EH; Kim, S; Lee, SK; Min, HY; Park, EJ | 1 |
| Georg, GI; Niphakis, MJ | 1 |
| Cui, M; Feng, A; Song, H; Wang, Q; Wang, Z | 1 |
| Bastow, KF; Chen, CY; Lai, CY; Lee, KH; Lin, JC; Morris-Natschke, SL; Pan, SL; Shi, Q; Teng, CM; Wu, PC; Wu, TS; Yang, PC; Yang, SC; Yang, X; Yu, SL | 1 |
| Biazzo, J; Gibson, DM; Krasnoff, SB; Milbrath, L | 1 |
| Chung, HJ; Kim, EH; Kim, S; Lee, SK; Min, HY; Park, HJ; Song, J | 1 |
| Gao, S; Xi, Z; Yu, Z; Zhang, R | 1 |
| Bastow, KF; Chen, CY; Lai, CY; Lee, KH; Ohkoshi, E; Pan, SL; Shi, Q; Teng, CM; Wang, CY; Wu, TS; Yang, PC; Yang, SC; Yang, X | 1 |
| Liu, Y; Wang, L; Wang, Q; Wang, Z; Wei, P; Xizhi, X | 1 |
| Liu, Y; Park, CM; Xu, X | 1 |
| Chung, HJ; In, J; Kim, S; Kwon, Y; Lee, B; Lee, SK; Song, H; Song, J | 1 |
| Han, G; Liu, Y; Wang, Q; Wang, Z; Wu, M | 1 |
| Huang, YF; Jow, GM; Liao, CK; Lin, JC; Wang, HS; Wu, JC | 1 |
| Chen, Y; Wu, DM; Wu, L | 1 |
| Liu, Y; Wang, Q; Zheng, Y | 1 |
| Bae, SJ; Hwang, ES; Jang, EJ; Jeong, H; Jeong, MG; Kim, HK; Kim, S; Lee, SK; Lee, YS | 1 |
| Liu, Y; Wang, Q; Wang, Z; Wei, P | 1 |
| Kim, I; Kim, S; Kwon, Y | 1 |
| Gibson, DM; Milbrath, LR; Vaughan, RH | 1 |
| Liu, Y; Wang, L; Wang, Q; Wang, Z; Wei, P; Yu, X | 1 |
| Kim, S; Kwon, Y; Lee, SK; Song, J | 1 |
| Kim, EY; Kim, S; Kwon, Y; Lee, H; Lee, K; Lee, SK; Song, J | 1 |
| Chen, Z; Hu, D; Jin, L; Li, X; Yang, S | 1 |
| Gade, AB; Patil, NT | 1 |
| Liu, GQ; Opatz, T; Reimann, M | 1 |
| Kim, GD; Kim, S; Lee, SK; Oh, J | 1 |
| Hong, LN; Jia, JM; Rong, ZJ; Wang, AH; Wang, YM; Yang, YC; Zhang, Q | 1 |
| Bonner, C; Desveaux, D; Mogg, C; Schernthaner, J; Smith, M; Subramaniam, R; Wang, L | 1 |
| Li, Z; Robeyns, K; Song, L; Tian, G; Van der Eycken, EV; Van Meervelt, L | 1 |
| Che, J; Li, L; Okwong, RO; OuYang, Q; Tao, N; Xin, Z; Zhou, J | 1 |
| Abdalla, AN; Abdullah, O; Chen, L; Fischer, PM; Guise, CP; Liu, Y; Omran, Z; Patterson, AV; Rauch, C; Sindi, IA; Smaill, JB; Wang, Q | 1 |
42 other study(ies) available for 1,7-phenanthroline and antofine
| Article | Year |
|---|---|
Cytotoxic activity and G2/M cell cycle arrest mediated by antofine, a phenanthroindolizidine alkaloid isolated from Cynanchum paniculatum.
Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Cynanchum; Drug Screening Assays, Antitumor; Humans; Indoles; Phenanthrolines; Tumor Cells, Cultured | 2003 |
First asymmetric total synthesis of (-)-antofine by using an enantioselective catalytic phase transfer alkylation.
Topics: Alkaloids; Alkylation; Catalysis; Cyclization; Indoles; Phenanthrolines; Pyrrolidines; Stereoisomerism | 2003 |
Asymmetric total syntheses of (-)-antofine and (-)-cryptopleurine using (R)-(E)-4-(tributylstannyl)but-3-en-2-ol.
Topics: Alkaloids; Alkylation; Animals; Butanols; Cyclization; Indoles; Molecular Structure; Organotin Compounds; Phenanthrolines; Piperidines; Pyrrolidines; Quinolizines; Stereoisomerism | 2004 |
Total syntheses of the tylophora alkaloids cryptopleurine, (-)-antofine, (-)-tylophorine, and (-)-ficuseptine C.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Indoles; Indolizines; Phenanthrenes; Phenanthrolines | 2006 |
Total synthesis of antofine using the net [5+5]-cycloaddition of gamma,delta-unsaturated carbene complexes and 2-alkynylphenyl ketones as a key step.
Topics: Hydrocarbons; Indoles; Ketones; Methane; Molecular Structure; Phenanthrolines | 2006 |
Synthesis and structure-activity studies of antofine analogues as potential anticancer agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Indoles; Phenanthrolines; Structure-Activity Relationship | 2007 |
Expedient syntheses of antofine and cryptopleurine via intramolecular 1,3-dipolar cycloaddition.
Topics: Alkaloids; Heterocyclic Compounds; Indoles; Isomerism; Molecular Structure; Phenanthrolines | 2007 |
Total synthesis of phenanthroindolizidine alkaloids (+/-)-antofine, (+/-)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity.
Topics: Alkaloids; Bromides; Cell Line, Tumor; Chlorides; Drug Resistance, Neoplasm; Humans; Indoles; Indolizines; Isoquinolines; KB Cells; Phenanthrolines | 2008 |
Antitumor agents 268. Design, synthesis, and mechanistic studies of new 9-substituted phenanthrene-based tylophorine analogues as potent cytotoxic agents.
Topics: Alkaloids; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Humans; Indoles; Indolizines; Models, Molecular; Molecular Conformation; NF-kappa B; Phenanthrenes; Phenanthrolines; Piperidines; Proto-Oncogene Proteins c-akt; Signal Transduction; Stereoisomerism; Structure-Activity Relationship | 2009 |
Inhibition of lipopolysaccharide-induced nitric oxide production by antofine and its analogues in RAW 264.7 macrophage cells.
Topics: Animals; Indoles; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Phenanthrolines; Structure-Activity Relationship | 2010 |
Antitumor agents. 274. A new synthetic strategy for E-ring SAR study of antofine and cryptopleurine analogues.
Topics: Alkaloids; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Indoles; Molecular Structure; Phenanthrolines; Stereoisomerism; Structure-Activity Relationship | 2010 |
Inhibition of cell growth and potentiation of tumor necrosis factor-α (TNF-α)-induced apoptosis by a phenanthroindolizidine alkaloid antofine in human colon cancer cells.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclin D1; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Indoles; Mice; Mice, Inbred BALB C; Phenanthrolines; Signal Transduction; Tumor Necrosis Factor-alpha; Wnt Proteins | 2010 |
Total syntheses of arylindolizidine alkaloids (+)-ipalbidine and (+)-antofine.
Topics: Indoles; Indolizines; Molecular Structure; Phenanthrolines; Stereoisomerism | 2010 |
Asymmetric synthesis of (R)-antofine and (R)-cryptopleurine via proline-catalyzed sequential α-aminoxylation and Horner-Wadsworth-Emmons olefination of aldehyde.
Topics: Aldehydes; Alkaloids; Catalysis; Indoles; Molecular Structure; Phenanthrolines; Proline; Stereoisomerism | 2010 |
Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents.
Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Line, Tumor; DNA Replication; Drug Design; Drug Screening Assays, Antitumor; Indoles; Mice; Neoplasm Transplantation; Phenanthrolines; S Phase; Stereoisomerism; Structure-Activity Relationship; Transplantation, Heterologous | 2011 |
Phytotoxicity of antofine from invasive swallow-worts.
Topics: Apocynum; Asclepias; Indoles; Lactuca; Phenanthrolines; Plant Extracts; Plant Weeds | 2011 |
Anti-proliferative activity and suppression of P-glycoprotein by (-)-antofine, a natural phenanthroindolizidine alkaloid, in paclitaxel-resistant human lung cancer cells.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Cell Line, Tumor; Cell Proliferation; DNA Primers; Drug Resistance, Neoplasm; Humans; Indoles; Lung Neoplasms; Paclitaxel; Phenanthrolines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction | 2012 |
Antofine analogues can inhibit tobacco mosaic virus assembly through small-molecule-RNA interactions.
Topics: Antiviral Agents; Capsid Proteins; Crystallography, X-Ray; Indoles; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Molecular Weight; Phenanthrolines; RNA, Viral; Tobacco Mosaic Virus | 2012 |
Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.
Topics: Adenocarcinoma; Alkaloids; Antineoplastic Agents; beta Catenin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Design; Drug Screening Assays, Antitumor; HSP90 Heat-Shock Proteins; Humans; Indoles; Lung Neoplasms; Phenanthrolines; Quinolizidines; Stereoisomerism; Structure-Activity Relationship | 2012 |
Design, synthesis, and antiviral activity evaluation of phenanthrene-based antofine derivatives.
Topics: Antiviral Agents; Drug Design; Indoles; Molecular Structure; Phenanthrenes; Phenanthrolines; Ribavirin; RNA, Viral; Structure-Activity Relationship; Tobacco Mosaic Virus | 2012 |
Rhodium(III)-catalyzed intramolecular annulation through C-H activation: total synthesis of (±)-antofine, (±)-septicine, (±)-tylophorine, and rosettacin.
Topics: Alkaloids; Alkynes; Carbon; Catalysis; Cyclization; Heterocyclic Compounds, 4 or More Rings; Hydrogen; Indoles; Indolizines; Isoquinolines; Phenanthrenes; Phenanthrolines; Pyridones; Rhodium; Stereoisomerism | 2012 |
Design, synthesis, and evaluation of a water-soluble antofine analogue with high antiproliferative and antitumor activity.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; G1 Phase Cell Cycle Checkpoints; HCT116 Cells; HEK293 Cells; Humans; Indoles; Lung Neoplasms; Mice; Mice, Nude; Phenanthrolines; Signal Transduction; Stereoisomerism; TOR Serine-Threonine Kinases; Transplantation, Heterologous; Water | 2013 |
Synthesis and antiviral activities of antofine analogues with different C-6 substituent groups.
Topics: Antiviral Agents; Indoles; Magnetic Resonance Spectroscopy; Phenanthrolines; RNA, Viral; Structure-Activity Relationship; Tobacco Mosaic Virus | 2013 |
Antofine-induced connexin43 gap junction disassembly in rat astrocytes involves protein kinase Cβ.
Topics: Animals; Animals, Newborn; Astrocytes; Calcium; Cell Communication; Cells, Cultured; Chelating Agents; Connexin 43; Dose-Response Relationship, Drug; Endocytosis; Enzyme Activation; Female; Gap Junctions; Indoles; Lysosomes; Male; Microscopy, Fluorescence; Phenanthrolines; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Time Factors; Vesicular Transport Proteins | 2013 |
[Preparation and anti-breast cancer activity of (-)-antofine carried with liposomes].
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Drug Carriers; Drug Compounding; Drug Stability; Female; Humans; Indoles; Liposomes; MCF-7 Cells; Mice; Mice, Nude; Nanoparticles; Particle Size; Phenanthrolines; Solubility; Xenograft Model Antitumor Assays | 2013 |
Collective asymmetric synthesis of (-)-antofine, (-)-cryptopleurine, (-)-tylophorine, and (-)-tylocrebrine with tert-butanesulfinamide as a chiral auxiliary.
Topics: Alkaloids; Butanes; Indoles; Indolizines; Isomerism; Molecular Structure; Phenanthrenes; Phenanthrolines; Stereoisomerism; Sulfonamides | 2014 |
Anti-adipogenic activity of the naturally occurring phenanthroindolizidine alkaloid antofine via direct suppression of PPARγ expression.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Apocynaceae; Biological Products; Cell Differentiation; Dose-Response Relationship, Drug; Down-Regulation; Indoles; Lipid Droplets; Mice; Phenanthrolines; Plant Roots; PPAR gamma; Structure-Activity Relationship | 2014 |
D and E rings may not be indispensable for antofine: discovery of phenanthrene and alkylamine chain containing antofine derivatives as novel antiviral agents against tobacco mosaic virus (TMV) based on interaction of antofine and TMV RNA.
Topics: Antiviral Agents; Drug Design; Indoles; Molecular Structure; Phenanthrenes; Phenanthrolines; RNA, Viral; Structure-Activity Relationship; Tobacco Mosaic Virus | 2014 |
Platinum-catalyzed synthesis of substituted phenanthrenes from biphenyl propargyl alcohols via a carbene intermediate.
Topics: Alkynes; Catalysis; Cyclization; Indoles; Methane; Molecular Structure; Phenanthrenes; Phenanthrolines; Platinum Compounds; Propanols | 2014 |
Invasive swallow-worts: an allelopathic role for -(-) antofine remains unclear.
Topics: Cynanchum; Indoles; Introduced Species; New York; Phenanthrolines; Rhizosphere; Soil; Vincetoxicum | 2015 |
Design, synthesis, antiviral activity and mode of action of phenanthrene-containing N-heterocyclic compounds inspired by the phenanthroindolizidine alkaloid antofine.
Topics: Alkaloids; Antiviral Agents; Drug Design; Heterocyclic Compounds; Indoles; Indolizines; Phenanthrenes; Phenanthrolines; Ribavirin; Structure-Activity Relationship; Tobacco Mosaic Virus | 2016 |
Antitumor activity of phenanthroindolizidine alkaloids is associated with negative regulation of Met endosomal signaling in renal cancer cells.
Topics: Alkaloids; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Endocytosis; Endosomes; Humans; Indoles; Indolizines; Kidney Neoplasms; Microscopy, Confocal; Phenanthrolines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-met; RNA Interference; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; Stereoisomerism | 2015 |
Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents.
Topics: Administration, Oral; Alkaloids; Animals; Antineoplastic Agents; Biological Availability; Cell Cycle; Cell Line, Tumor; Cell Movement; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; Female; Humans; Indoles; Male; MAP Kinase Signaling System; Mice, Inbred ICR; Mice, Nude; Molecular Structure; Nicotinamide N-Methyltransferase; Phenanthrolines; Structure-Activity Relationship; Sulfonamides | 2015 |
New Strategies and Methods to Study Interactions between Tobacco Mosaic Virus Coat Protein and Its Inhibitors.
Topics: Amino Acid Sequence; Antiviral Agents; Benzothiazoles; Capsid Proteins; Cytidine; Indoles; Molecular Sequence Data; Phenanthrolines; Protein Binding; Tobacco Mosaic Virus | 2016 |
Gold(I)-Catalyzed Hydroaminaloxylation and Petasis-Ferrier Rearrangement Cascade of Aminaloalkynes.
Topics: Alkynes; Biochemical Phenomena; Catalysis; Gold; Indoles; Molecular Structure; Phenanthrolines | 2016 |
Total Synthesis of Phenanthroindolizidine Alkaloids by Combining Iodoaminocyclization with Free Radical Cyclization.
Topics: Alkaloids; Chemistry, Organic; Cyclization; Free Radicals; Indoles; Indolizines; Isoquinolines; Magnetic Resonance Spectroscopy; Phenanthrenes; Phenanthrolines; Pyrrolidines; Stereoisomerism; Structure-Activity Relationship; Temperature | 2016 |
Antofine, a natural phenanthroindolizidine alkaloid, suppresses angiogenesis via regulation of AKT/mTOR and AMPK pathway in endothelial cells and endothelial progenitor cells derived from mouse embryonic stem cells.
Topics: AMP-Activated Protein Kinases; Angiogenesis Inhibitors; Animals; Cell Proliferation; Endothelial Progenitor Cells; Humans; Indoles; Indolizines; Mice; Mouse Embryonic Stem Cells; Neovascularization, Pathologic; Phenanthrolines; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A | 2017 |
Phytochemical and antitumor studies on
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cynanchum; Drug Screening Assays, Antitumor; Humans; Indoles; Molecular Structure; Phenanthrolines; Phytochemicals | 2020 |
Genomic Identification of the TOR Signaling Pathway as a Target of the Plant Alkaloid Antofine in the Phytopathogen Fusarium graminearum.
Topics: Fungicides, Industrial; Fusarium; Genomics; Indoles; Phenanthrolines; Plant Diseases; Signal Transduction; TOR Serine-Threonine Kinases; Triticum; Virulence | 2019 |
A Gold(I)-Catalyzed Hydroamination/Cycloisomerization Cascade: Concise Synthesis of (±)-seco-Antofine and (±)-Septicine.
Topics: Alkaloids; Amines; Catalysis; Cyclization; Gold; Indoles; Isomerism; Phenanthrolines | 2020 |
Antofine inhibits postharvest green mold due to imazalil-resistant Penicillium digitatum strain Pdw03 by triggering oxidative burst.
Topics: Imidazoles; Indoles; Penicillium; Phenanthrolines; Respiratory Burst | 2021 |
Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents.
Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; CHO Cells; Cricetulus; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Indoles; Indolizines; MCF-7 Cells; Molecular Structure; Phenanthrenes; Phenanthrolines; Prodrugs; Quaternary Ammonium Compounds; Structure-Activity Relationship; Tumor Hypoxia | 2021 |