1,7-dimethylxanthine has been researched along with caffeine in 246 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (16.67) | 18.7374 |
| 1990's | 64 (26.02) | 18.2507 |
| 2000's | 66 (26.83) | 29.6817 |
| 2010's | 60 (24.39) | 24.3611 |
| 2020's | 15 (6.10) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Bearne, SL; Lunn, FA; Roy, AC | 1 |
| Gonzalez, FJ; Gu, L; Kalow, W; Tang, BK | 1 |
| Fukao, K; Ishikawa, A; Iwasaki, Y; Misawa, S; Osada, A; Tanaka, E; Tsuji, K; Yamamoto, Y | 1 |
| Anders, EM; Fuhr, U; Mahr, G; Sörgel, F; Staib, AH | 1 |
| Blanchard, J; Shearer, LE; Weber, CW | 2 |
| Fuhr, U; Roots, I; Rost, KL; Staib, AH | 1 |
| Tanaka, E | 1 |
| Moncrieff, J | 1 |
| Ferre, S; Guix, T; Jane, F; Limon, A; Parra, P | 1 |
| Andén, NE; Casas, M; Ferré, S; Grabowska-Andén, M; Herrera-Marschitz, M; Ungerstedt, U | 1 |
| Arzubiaga, C; Biaggioni, I; Paul, S; Puckett, A | 1 |
| Musk, SR; Steel, GG | 1 |
| Healy, DP; Polk, RE; Schoenle, JR; Stotka, J | 1 |
| Badia, A; Casas, M; Ferré, S; Guix, T; Herrera-Marschitz, M; Jané, F; Parra, P; Sallés, J; Ungerstedt, U | 1 |
| Badcock, NR | 1 |
| Levy, G; Zhi, JG | 1 |
| Brown, DD; Hetzler, RK; Knowlton, RG; Perkins, RM; Somani, SM | 1 |
| Beitins, IZ; Kilbane, AJ; Manis, M; Silbart, LK; Weber, WW | 1 |
| Butler, MA; Kadlubar, FF; Lang, NP; Massengill, JP; Talaska, G; Teitel, CH | 1 |
| Benowitz, NL; Brown, CR; Denaro, CP; Jacob, P; Wilson, M | 1 |
| Gilboe, DP | 1 |
| Holtzman, SG | 1 |
| Chakraborty, J; Marks, V; Morgan, MY; Scott, NR; Stambuk, D | 1 |
| Hafkenscheid, JC; Hekster, YA; Nouws, JF; Vree, JB; Vree, TB | 1 |
| Healy, DP; Kanawati, L; Mooney, ML; Polk, RE; Rock, DT | 1 |
| Beer, C; Harder, S; Papenburg, A; Shah, PM; Staib, AH; Stille, W | 1 |
| Birkett, DJ; Kjellen, G; Lelo, A; Miners, JO | 1 |
| Gerok, W; Haag, K; Holstege, A; Staiger, M | 1 |
| Nakazawa, K; Tanaka, H | 1 |
| Dorrbecker, BR; Dorrbecker, SH; Kramer, PA; Raye, JR | 2 |
| Dorrbecker, BR; Dorrbecker, SH; Ferraina, RA; Kramer, PA | 1 |
| Carney, JM; Logan, L; Seale, TW | 1 |
| Birkett, DJ; Lelo, A; Miners, JO; Robson, RA | 2 |
| Grgurinovich, N | 1 |
| Chakraborty, J; Marks, V; Scott, NR | 1 |
| Randall, JL; Scott, WJ; York, RG | 1 |
| Carney, JM; Holloway, FA; Modrow, HE | 1 |
| Karlaganis, G; Renner, E; Wahlländer, A | 1 |
| Arima, M; Nakazawa, K; Tanaka, H | 1 |
| Cookman, JR; Hartley, R; Smith, IJ | 2 |
| Goshorn, C; Hinsvark, O; Park, YH | 1 |
| Bonati, M; Bortolotti, A; Gaspari, F; Jiritano, L | 1 |
| Preisig, R; Wahlländer, A; Zysset, T | 1 |
| Branfman, AR; Callahan, MM; Yesair, DW | 1 |
| Spindel, E | 1 |
| Fujii, T; Hanada, S; Nakatsuka, T | 1 |
| Arima, M; Iwasaki, S; Nakazawa, K; Tanaka, H | 1 |
| Gabel, H; Schulz, HU; Steinijans, VW | 1 |
| Dorrbecker, BR; Kramer, PA; Mercik, SH | 1 |
| Riegelman, S; Tang-Liu, DD; Williams, RL | 1 |
| Renner, HW | 1 |
| Kunitani, M; Muir, KT; Riegelman, S | 1 |
| Assenza, SP; Brown, PR; Nakano, K | 1 |
| Bonati, M; Garattini, S; Latini, R; Marzi, E | 1 |
| Braeckman, P; Moerman, E; Van Aerde, P; Van Severen, R | 1 |
| Szeto, DW; Tse, FL | 1 |
| Riegelman, S; Tang-Liu, DD | 1 |
| Farrish, HH; Wargin, WA | 1 |
| Bresnick, E; McQuilkin, SH; Nierenberg, DW | 1 |
| Chen, A; Lunte, CE | 1 |
| Fuhr, U; Rost, KL | 1 |
| Dulloo, AG; Girardier, L; Seydoux, J | 1 |
| Galteau, MM; Gueguen, R; Pontes, ZB; Siest, G; Vincent-Viry, M | 1 |
| Edwards, G; Glazier, AP; Kokwaro, GO; Szwandt, IS; Ward, SA | 1 |
| Roots, I; Rost, KL | 1 |
| Andersson, T; Birkett, DJ; McManus, ME; Miners, JO; Tassaneeyakul, W; Tukey, RH; Veronese, ME | 1 |
| Graham, TE; Sathasivam, P; Spriet, LL; Van Soeren, MH | 1 |
| Pollard, I; Wilkinson, JM | 1 |
| Fukao, K; Ishikawa, A; Iwasaki, Y; Osada, A; Tanaka, E; Tsuji, K; Yamamoto, Y | 1 |
| Gerok, W; Holstege, A; Kurz, M; Weinbeck, M | 1 |
| Benowitz, NL; Denaro, C; Jacob, P; Mayan, H | 1 |
| Ishikawa, A; Misawa, S; Tanaka, E | 1 |
| Benowitz, NL; Denaro, CP; Jacob, P; Wilson, M | 1 |
| Downing, J; Pollard, I; Scaramuzzi, R; Williamson, S | 1 |
| Norman, A; Rodopoulos, N | 1 |
| Bartsch, H; Bernucci, I; Caporaso, NE; Kadlubar, FF; Landi, MT; Malaveille, C; Shields, P; Skipper, P; Tannenbaum, S; Vineis, P; Zocchetti, C | 1 |
| Aramaki, S; Ishidaka, O; Momose, A; Suzuki, E; Umemura, K | 1 |
| Akiyama, S; Hamachi, Y; Inoue, K; Kuroda, N; Mayahara, K; Nakashima, K | 1 |
| Benchekroun, Y; Brazier, JL; Dautraix, S; Désage, M | 1 |
| Lunte, CE; Zhao, Y | 1 |
| Ishikura, C; Ishizuka, H; Kouno, Y; Samizo, K | 1 |
| Beaune, P; Belloc, C; Engelhardt, R; Fuhr, U; Grant, D; Janezic, S; Liermann, D; Meyer, UA; Rost, KL; Sachs, M; Staib, AH | 1 |
| Matthews, NS; Mealey, KL; Peck, K; Taylor, TS | 1 |
| Casley, WL; Girard, M; Larocque, L; Menzies, JA; Moon, TW; Mousseau, N; Whitehouse, LW | 1 |
| Clemens, JD; Dersimonian, R; Klebanoff, MA; Levine, RJ; Wilkins, DG | 2 |
| Connor, JD; Godfredsen, KA; Holland, DT; Page, T | 1 |
| Han, LK; Jiang, M; Kameda, K; Kimura, Y; Okuda, H | 1 |
| Jodynis-Liebert, J; Matuszewska, A | 1 |
| Bernal, ML; Fanlo, A; Juste, JL; Lanuza, J; Mayayo, E; Sáenz, MA; Sinués, B | 1 |
| Dahlqvist, R; Hägg, S; Söderström, E; Spigset, O | 2 |
| Fuhr, U; Rietbrock, S; Tantcheva-Poór, I; Zaigler, M | 1 |
| Guchelaar, HJ; Koch, JP; Koppe, JG; ten Tusscher, GW | 1 |
| Daly, JW; Shi, D | 1 |
| Condifer, KA; Folan, MM; Kirshner, MA; Pollock, BG; Sorisio, DA; Stack, JA; Thompson, DS; Wylie, M | 1 |
| Lewis, IA; Palmer, J; Pleasance, S; Scott, RJ | 1 |
| Casley, WL; Menzies, JA; Moon, TW; Whitehouse, LW | 1 |
| Eskenazi, B | 1 |
| Bohnemeier, H; Brockmöller, J; Fuhr, U; Roots, I; Rost, KL; Thomsen, T; Zaigler, M | 1 |
| Dahlqvist, R; Hägg, S; Mjörndal, T; Spigset, O | 1 |
| Huang, SL; Ou-Yang, DS; Shu, Y; Wang, W; Xie, HG; Xu, ZH; Zhou, HH | 1 |
| Horsmans, Y; Spatzenegger, M; Verbeeck, RK | 1 |
| Grant, MM; Jester, DM | 1 |
| Dericks-Tan, JS; Fuhr, U; Rietbrock, S; Staib, AH; Szymanski, J; Zaigler, M | 1 |
| Akinyinka, OO; Honeywell, R; Renwick, AG; Sowunmi, A | 2 |
| Forsyth, JT; Grünewald, RA; Lennard, MS; Rostami-Hodjegan, A; Sagar, HJ; Tucker, GT | 1 |
| Adedoyin, A; Branch, RA; Frye, RF; Romkes, M; Wilson, JW | 1 |
| Allen, DG; Hawke, TJ; Lindinger, MI | 1 |
| Castro, GD; Castro, JA; Costantini, MH; Delgado de Layño, AM | 1 |
| Fredholm, BB; Irenius, E; Kull, B; Schulte, G | 1 |
| Perlík, F; Pucelíková, T; Slanar, O | 1 |
| Dorne, JL; Renwick, AG; Walton, K | 2 |
| Bruce, MA; Gorski, JC; Haehner-Daniels, BD; Hall, SD | 1 |
| Choo, EF; Mayo, G; Shyr, Y; Sofowora, GG; Wilkinson, GR | 1 |
| Cao, XM; Ling, SS; Lu, JF; Yi, T; Zhuo, HT | 1 |
| Cao, XM; Lin, SS; Lu, JF; Yi, T; Zhuo, HT | 1 |
| Barrett, E; Coggins, M; Fasy, E; Jahn, L; Kaul, S; Lindner, J; Rattigan, S | 1 |
| Becquemont, L; Chodjania, Y; Funck-Brentano, C; Hamon, B; Jaillon, P; Nouyrigat, E; Poirier, JM; Simon, T | 1 |
| Crews, HM; Olivier, L; Wilson, LA | 1 |
| Clemens, JD; Klebanoff, MA; Levine, RJ; Wilkins, DG | 1 |
| Hammons, G; Kadlubar, FF; Lang, NP; Nowell, S; Sweeney, C | 1 |
| Buters, J; Fuhr, U; Jabrane, W; Labedzki, A | 1 |
| Gasior, M; Goldberg, SR; Jaszyna, M; Munzar, P; Witkin, JM | 1 |
| Abraham, K; Bauer, S; Brockmöller, J; Geusau, A; Helge, H; Tosun, Y | 1 |
| Conway, KJ; Orr, R; Stannard, SR | 1 |
| Li, L; Liao, J; Zhou, CX | 1 |
| Chou, CC; Vickroy, TW | 1 |
| Baer-Dubowska, W; Cichocki, M; Jodynis-Liebert, J; Matuszewska, A; Szaefer, H | 1 |
| Chen, XP; Huang, SL; Huang, Z; Ou-Yang, DS; Tan, ZR; Zhou, HH | 1 |
| Chung, WG; Ryu, SD | 1 |
| Doude van Troostwijk, LJ; Guchelaar, HJ; Koopmans, RP | 1 |
| Hinsui, Y; Lawanprasert, S; Wittayalertpanya, S | 1 |
| Bracken, MB; Grosso, L; Triche, E | 1 |
| Acheson, KJ; Fay, LB; Gay, LJ; Gremaud, G; Krebs, Y; Meirim, I; Montigon, F; Schindler, C; Schneiter, P; Tappy, L | 1 |
| Aiemsa-Ard, J; Gaysornsiri, D; Kukongviriyapan, U; Kukongviriyapan, V; Prawan, A; Senggunprai, L | 1 |
| Flieger, J; Jodynis-Liebert, J; Juszczyk, J; Matuszewska, A | 1 |
| Cihlar, T; Haefeli, WE; Lindenmaier, H; Rengelshausen, J; Walter-Sack, I; Weiss, J | 1 |
| Connor, TJ; Horrigan, LA; Kelly, JP | 1 |
| Beijnen, JH; de Jonge, ME; den Hoed, R; Hendriks, VM; Huitema, AD; Sparidans, RW; van den Brink, W; van Ree, JM; Zandvliet, AS | 1 |
| Groeneveld, GJ; Guchelaar, HJ; Kalmijn, S; Spieksma, M; van den Berg, LH; van Kan, HJ | 1 |
| Fujieda, M; Honda, G; Ishizaki, T; Kamataki, T; Kimura, M; Kiyotani, K; Nakagawa, K; Saruwatari, J; Yamazaki, H | 1 |
| Faber, MS; Fuhr, U; Jetter, A | 1 |
| Backman, JT; Granfors, MT; Laitila, J; Neuvonen, PJ | 1 |
| Bapiro, TE; Hasler, JA; Jande, M; Masimirembwa, CM; Masselle, A; Rimoy, G; Sayi, J | 1 |
| Belanger, K; Benowitz, NL; Bracken, MB; Grosso, LM; Holford, TR; Triche, EW | 1 |
| Li, J; Peng, XQ; Xu, JP; Zhang, J | 1 |
| Branch, RA; Chaves-Gnecco, D; Frye, RF; Matzke, GR; Rabinovitz, M; Shaikh, OS; Zgheib, NK | 1 |
| Asprodini, EK; Begas, E; Kouvaras, E; Papakosta, S; Tsakalof, A | 1 |
| Desbrow, B; Leveritt, M | 1 |
| Fuhr, U; Jetter, A; Kirchheiner, J | 1 |
| Clark, RS; Dixon, CE; Gillespie, DG; Jackson, EK; Kochanek, PM; Puccio, AM; Sachse, KT; Wisniewski, SR | 1 |
| Guchelaar, HJ; Ilsen, A; Koch, J; Koppe, JG; Olie, K; ten Tusscher, GW; van der Slikke, JW; Vulsma, T; Westra, M | 1 |
| Fanlo, A; Ferrandez-Longás, A; Labarta, JI; Mayayo, E; Mayayo-Sinués, E; Sinués, B; Vicente, J | 1 |
| Backman, JT; Neuvonen, PJ; Schröder, MT | 1 |
| Darwish, M; Hellriegel, ET; Kirby, M; Robertson, P | 1 |
| Boylan, SM; Cade, JE; Greenwood, DC; Hay, AW; Kirk, SF; Shires, S; Simpson, NA; White, KL; Wild, CP | 1 |
| Guerreiro, S; Hirsch, E; Marien, M; Michel, PP; Sokoloff, P; Toulorge, D | 1 |
| Arenaz, I; Carcas, C; Cebollada, A; Fanlo, A; Mayayo, E; Sinues, B; Vicente, J | 1 |
| Gressner, AM; Gressner, OA; Lahme, B; Siluschek, M | 1 |
| Gopishetty, S; Kale, Y; Louie, TM; Subramanian, M; Summers, R; Yu, CL | 1 |
| Dahl, ML; Gunes, A; Ozbey, G; Scordo, MG; Uluoglu, C; Vural, EH; Zengil, H | 1 |
| Chen, Y; Fan, L; He, YJ; Tan, ZR; Tu, JH; Wang, G; Zhang, W; Zhou, G; Zhou, HH | 1 |
| Gressner, OA | 1 |
| Jetsrisuparb, A; Kukongviriyapan, U; Kukongviriyapan, V; Senggunprai, L | 1 |
| Chen, JF; Schwarzschild, MA; Xu, K; Xu, YH | 1 |
| Fujiki, N; Ishimaru, Y; Kotorii, N; Nishino, S; Okuro, M; Sokoloff, P | 1 |
| Homma, M; Kobayashi, D; Kobayashi, T; Kohda, Y; Momo, K | 1 |
| Wang, X; Yeung, JH | 1 |
| Gómez-Martínez, LE | 1 |
| Gross, AS; McLachlan, AJ; Perera, V | 3 |
| Arnaud, MJ | 1 |
| Catov, J; Laughon, SK; Parana, S; Powers, RW; Roberts, JM | 1 |
| Bista, SR; Jahng, Y; Jeong, TC; Kang, MJ; Kang, W; Kim, E; Lee, SK; Noh, K; Seo, YM | 1 |
| Traş, B; Tumer, I; Uney, K | 1 |
| Begley, A; Buysse, DJ; Karpov, IO; Pollock, BG; Youngberg, MR | 1 |
| Gross, AS; McLachlan, AJ; Perera, V; Xu, H | 1 |
| Geyer, T; Hillebrand, O; Licha, T; Nödler, K; Sauter, M | 1 |
| Maass, S; Pinhancos, R; Ramanathan, DM | 1 |
| Chichirov, AA; Filimonova, AA; Ziganshin, AU; Ziganshina, LE | 1 |
| Kim, DH; Oh, KS; Park, SJ; Shin, JG; Shinde, DD | 1 |
| Carbó, ML; de la Torre, R; Farre, M; Langohr, K; Mathuna, BÓ; Mustata, C; Pardo, R; Perez-Mañá, C; Torrens, M; Yubero-Lahoz, S | 1 |
| Guan, H; Sharmin, S; Williams, AS; Yang, K | 1 |
| Kamataki, T; Kimura, M; Kiyotani, K; Nakagawa, K; Shimizu, M; Yamazaki, H | 1 |
| Cheng, ZN; Deng, X; Hu, Z; Wang, L; Wang, Y; Zhang, Z | 1 |
| Barodia, SK; Casado, V; Cortes, A; Ferré, S; Guitart, X; Justinova, Z; Karcz-Kubicha, M; Lluis, C; Moeller, FG; Orrú, M; Solinas, M; Zanoveli, J | 1 |
| Allan, MC; Dixon, L; Foster, L; Gurley, BJ; Hubbard, M; Khan, A; Moore, P; Williams, DK | 1 |
| Ghassabian, S; Murray, M | 1 |
| Bae, SH; Bae, SK; Choi, EJ; Jang, SM; Kwon, MJ; Lee, SJ; Lee, YS; Park, JB; Zheng, YF | 1 |
| Akamatsu, T; Chida, K; Inui, N; Karayama, M; Namiki, N; Tanaka, S; Uchida, S; Watanabe, H | 1 |
| Ait-Oudhia, S; Forrest, A; Gross, AS; Landersdorfer, CB; McLachlan, AJ; Perera, V; Xu, H | 1 |
| Litvin, AA; Novitskaia, IaG; Viglinskaia, AO; Zherdev, VP | 1 |
| Aharchi, F; De Smedt, G; Hoetelmans, RM; Kakuda, TN; Leopold, L; Onkelinx, J; Peeters, M; Stevens, T; Van Solingen-Ristea, RM | 1 |
| Fan, XR; Li, XY; Li, YF; Li, YP; Liu, YN; Yang, M; Yao, XC; Yin, YM; Yuan, M; Zhu, JB | 1 |
| De Kesel, PM; Lambert, WE; Stove, CP | 5 |
| Jarosz, M; Sawicki, W; Siuba, M; Wierzejska, R | 1 |
| Capiau, S; De Kesel, PM; Lambert, WE; Stove, CP; Stove, VV | 1 |
| Ackermann, D; Ansermot, N; Bochud, M; Burnier, M; Eap, CB; Ehret, G; Gu, Y; Guessous, I; Martin, PY; Mohaupt, M; Paccaud, F; Pechère-Berstchi, A; Pechère-Bertschi, A; Ponte, B; Pruijm, M; Staessen, J; Vogt, B; Vuistiner, P | 1 |
| Keim, SA; Klebanoff, MA | 2 |
| Ali, A; O'Donnell, JM; Rutherfurd-Markwick, KJ; Starck, C | 1 |
| Ahluwalia, N; Pao, CI; Pfeiffer, CM; Rybak, ME; Sternberg, MR | 1 |
| Lazenka, MF; Moeller, FG; Negus, SS | 1 |
| Flesch, FM; Jordan, NY; Mimpen, JY; Torano, JS; van de Meent, MH; van den Bogaard, WJ | 1 |
| Adehin, A; Bolaji, OO | 1 |
| Alharbi, O; Goodacre, R; Xu, Y | 1 |
| Baker, AM; Eichelberger, KY; Haeri, S; Strauss, RA; Stuebe, AM; Woodham, PC | 1 |
| Campbell, SC; Clark, EA; Schoen, K; Sherwin, CM; Spigarelli, MG; Stockmann, C; Tak, C; Varner, MW; Yu, T | 1 |
| Bulatov, A; Kirsanov, D; Medinskaia, K; Nikolaeva, L; Timofeeva, I | 1 |
| Chia, HY; Ho, HK; Yau, WP | 1 |
| Mitchell, EM; Mumford, SL; Perkins, NJ; Radin, RG; Schisterman, EF; Schliep, KC; Sjaarda, LA; Wactawski-Wende, J; Zarek, SM | 1 |
| Chan, SA; Lian, L; Pang, W; Song, W; Yao, B; Yin, D | 1 |
| Adamski, J; Artati, A; Bochud, M; Cornelis, MC; Eap, CB; Ehret, G; Friedrich, N; Ganna, A; Grabe, HJ; Guessous, I; Gustafsson, S; Homuth, G; Ingelsson, E; Kacprowski, T; Lind, L; Magnusson, PK; Mangino, M; Menni, C; Pedersen, NL; Pietzner, M; Pivin, E; Spector, TD; Suhre, K; Völzke, H | 1 |
| Cáceres, N; Dafouz, R; Rodríguez-Gil, JL; Valcárcel, Y | 1 |
| Stove, CP; Velghe, S | 1 |
| Anastasiadi, RM; Berti, F; Di Tommaso, D; Peressi, M; Pividori, M; Redivo, L; Resmini, M | 1 |
| Assi, N; Boeing, H; Boutron-Ruault, MC; Casagrande, C; Ferrari, P; Jenab, M; Katzke, V; Keski-Rahkonen, P; Krogh, V; Kühn, T; Mahamat-Saleh, Y; Mancini, FR; Mattiello, A; Niforou, K; Palli, D; Robinot, N; Rothwell, JA; Sacerdote, C; Scalbert, A; Trichopoulou, A; Tumino, R; Valanou, E | 1 |
| Deprez, S; Paniagua-González, L; Stove, CP; Velghe, S | 1 |
| Hu, B; Huang, Z; Li, ZM; Wu, L; Yuan, ZC | 1 |
| Chen, WL; Wu, SE | 1 |
| Amyx, M; Bever, AM; Buck Louis, GM; Gerlanc, N; Gleason, JL; Grantz, KL; Hinkle, SN; Kannan, K; Robinson, M; Smarr, MM; Sundaram, R; Tekola-Ayele, F; Vafai, Y | 1 |
| Alexander-White, C; Bury, D; Clewell, HJ; Cronin, M; Desprez, B; Detroyer, A; Efremenko, A; Firman, J; Hack, E; Hewitt, NJ; Kenna, G; Klaric, M; Lester, C; Mahony, C; Ouedraogo, G; Paini, A; Schepky, A | 1 |
| Critchley, D; Tayo, B; Thai, C | 1 |
| Goessler, W; Lajin, B; Obermayer-Pietsch, B; Schweighofer, N | 1 |
| Ackermann, D; Ansermot, N; Bochud, M; Dhayat, NA; Eap, CB; Ehret, G; Estoppey-Younès, S; Guessous, I; Martin, PY; Melgarejo, JD; Petrovic, D; Ponte, B; Pruijm, M; Staessen, JA; Stringhini, S; Thijs, L; Vogt, B; Zhang, Z | 1 |
| Kertys, M; Kmeťová, K; Maráková, K; Mokrý, J; Pršo, K; Žideková, N | 1 |
| Bileck, A; Brunmair, J; Feuerstein, ML; Gerner, C; Gotsmy, M; Janker, L; Langbauer, C; Meier-Menches, SM; Neuditschko, B; Niederstaetter, L; Slany, A; Zanghellini, J | 1 |
| Guan, W; Mumford, SL; Polinski, KJ; Purdue-Smithe, A; Robinson, SL; Schisterman, EF; Schliep, KC; Silver, RM; Yeung, EH; Zhao, SK | 1 |
| Arcega-Cabrera, F; Herrera-Silveira, J; Lamas-Cosío, E; León-Aguirre, K; Martínez-Casales, Y; Noreña-Barroso, E | 1 |
| Daali, Y; Desmeules, J; Magliocco, G; Samer, CF; Thomas, A | 1 |
| Kinzig, M; Pietrzak-Fiećko, R; Purkiewicz, A; Sörgel, F | 1 |
| Aoyama, K; Bhadhprasit, W; Kinoshita, C; Matsumura, N; Nakaki, T | 1 |
| Aoyama, K; Matsumura, N | 1 |
10 review(s) available for 1,7-dimethylxanthine and caffeine
| Article | Year |
|---|---|
Human disposition and some biochemical aspects of methylxanthines.
Topics: Caffeine; Contraceptives, Oral; Female; Humans; Intestinal Absorption; Kinetics; Male; Theobromine; Theophylline; Tissue Distribution | 1984 |
Action of the methylxanthines on the pituitary and pituitary-dependent hormones.
Topics: Adrenal Glands; Animals; Caffeine; Female; Growth Hormone; Humans; Male; Pituitary Gland; Prolactin; Theobromine; Theophylline; Thyroid Gland; Thyrotropin; Time Factors | 1984 |
Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates.
Topics: Animals; Caffeine; Cytochrome P-450 CYP1A2; Dogs; Humans; Mice; Models, Biological; Pharmacokinetics; Probability; Rabbits; Rats; Reproducibility of Results; Risk Assessment; Species Specificity; Substrate Specificity; Theobromine; Theophylline | 2001 |
Uncertainty factors for chemical risk assessment. human variability in the pharmacokinetics of CYP1A2 probe substrates.
Topics: Adult; Aged; Area Under Curve; Caffeine; Child; Cytochrome P-450 CYP1A2; Humans; Infant, Newborn; Models, Biological; Pharmacokinetics; Probability; Reproducibility of Results; Risk Assessment; Substrate Specificity; Theobromine; Theophylline; Warfarin | 2001 |
Assessment of CYP1A2 activity in clinical practice: why, how, and when?
Topics: Animals; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Enzyme Induction; Genotype; Humans; Liver; Pharmaceutical Preparations; Phenotype; Saliva; Theophylline | 2005 |
Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach.
Topics: Administration, Oral; ATP-Binding Cassette Transporters; Caffeine; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Pharmaceutical Preparations; Phenotype; Theophylline; Tolbutamide | 2007 |
Interaction profile of armodafinil with medications metabolized by cytochrome P450 enzymes 1A2, 3A4 and 2C19 in healthy subjects.
Topics: Administration, Oral; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Clinical Trials as Topic; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Half-Life; Humans; Injections, Intravenous; Male; Metabolic Clearance Rate; Midazolam; Mixed Function Oxygenases; Modafinil; Pharmaceutical Preparations; Theophylline | 2008 |
Less Smad2 is good for you! A scientific update on coffee's liver benefits.
Topics: Acetylgalactosamine; Animals; Caffeine; Carcinoma, Hepatocellular; Collagen Type I; Connective Tissue Growth Factor; Humans; Liver; Liver Neoplasms; Proteasome Endopeptidase Complex; Smad2 Protein; Theophylline; Transforming Growth Factor beta; Xanthines | 2009 |
Measurement of CYP1A2 activity: a focus on caffeine as a probe.
Topics: Animals; Breath Tests; Caffeine; Cytochrome P-450 CYP1A2; Humans; Saliva; Theobromine; Theophylline | 2012 |
Glutathione-Mediated Neuroprotective Effect of Purine Derivatives.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Brain; Caffeine; Cysteine; Excitatory Amino Acid Transporter 3; Glutathione; Humans; Neuroprotection; Neuroprotective Agents; Parkinson Disease; Purines; Receptor, Adenosine A2A; Theophylline; Uric Acid | 2023 |
36 trial(s) available for 1,7-dimethylxanthine and caffeine
| Article | Year |
|---|---|
Lack of interaction between lomefloxacin and caffeine in normal volunteers.
Topics: 4-Quinolones; Adult; Anti-Infective Agents; Caffeine; Double-Blind Method; Drug Interactions; Fluoroquinolones; Half-Life; Humans; Male; Quinolones; Theophylline | 1991 |
Dose-dependency of caffeine metabolism with repeated dosing.
Topics: Adult; Caffeine; Cardiovascular Diseases; Coffee; Dose-Response Relationship, Drug; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Random Allocation; Risk Factors; Theobromine; Theophylline | 1990 |
4-quinolones inhibit biotransformation of caffeine.
Topics: Adult; Biotransformation; Caffeine; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Interactions; Enoxacin; Humans; Male; Molecular Structure; Norfloxacin; Ofloxacin; Pipemidic Acid; Quinolones; Random Allocation; Theophylline | 1988 |
Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva.
Topics: Adult; Aged; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Molecular Probes; Oxidoreductases; Phenotype; Reference Values; Retrospective Studies; Saliva; Theophylline | 1994 |
Caffeine metabolism and epinephrine responses during exercise in users and nonusers.
Topics: Adult; Blood Glucose; Caffeine; Catecholamines; Epinephrine; Exercise; Fatty Acids, Nonesterified; Glycerol; Habituation, Psychophysiologic; Humans; Lactates; Lactic Acid; Male; Oxygen Consumption; Substance Withdrawal Syndrome; Theophylline | 1993 |
Sympathomimetic effects of paraxanthine and caffeine in humans.
Topics: Adult; Blood Pressure; Caffeine; Central Nervous System Stimulants; Epinephrine; Fatty Acids; Female; Heart Rate; Humans; Male; Middle Aged; Norepinephrine; Reference Values; Theophylline | 1995 |
Validation of urine caffeine metabolite ratios with use of stable isotope-labeled caffeine clearance.
Topics: Adult; Analysis of Variance; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Injections, Intravenous; Isotope Labeling; Male; Middle Aged; Oxidoreductases; Reference Values; Regression Analysis; Smoking; Theophylline | 1996 |
Lack of correlation between fluvoxamine clearance and CYP1A2 activity as measured by systemic caffeine clearance.
Topics: Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Drug Interactions; Fluvoxamine; Humans; Male; Selective Serotonin Reuptake Inhibitors; Theophylline | 1999 |
The paraxanthine:caffeine ratio in serum or in saliva as a measure of CYP1A2 activity: when should the sample be obtained?
Topics: Adult; Area Under Curve; Caffeine; Cytochrome P-450 CYP1A2; Humans; Male; Saliva; Specimen Handling; Theophylline | 1999 |
Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women.
Topics: Aged; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Estradiol; Estrogen Replacement Therapy; Female; Humans; Menopause; Middle Aged; Theophylline | 1999 |
Omeprazole weakly inhibits CYP1A2 activity in man.
Topics: Adult; Binding, Competitive; Biomarkers; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Omeprazole; Single-Blind Method; Theophylline | 1999 |
Effect of caffeine on clozapine pharmacokinetics in healthy volunteers.
Topics: Adult; Antipsychotic Agents; Area Under Curve; Biotransformation; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Clozapine; Cross-Over Studies; Humans; Male; Theophylline | 2000 |
Phenotypic polymorphism and gender-related differences of CYP1A2 activity in a Chinese population.
Topics: Adolescent; Adult; Caffeine; China; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Data Interpretation, Statistical; Female; Humans; Male; Metabolic Clearance Rate; Phenotype; Polymorphism, Genetic; Sex Factors; Theophylline | 2000 |
Variation of CYP1A2-dependent caffeine metabolism during menstrual cycle in healthy women.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Female; Humans; Male; Menstrual Cycle; Middle Aged; Pilot Projects; Saliva; Theophylline | 2000 |
The pharmacokinetics of caffeine in Nigerian children suffering from malaria and kwashiorkor.
Topics: Administration, Oral; Caffeine; Child; Child, Preschool; Cytochrome P-450 CYP1A2; Female; Half-Life; Humans; Infant; Kwashiorkor; Malaria; Male; Metabolic Clearance Rate; Nigeria; Theophylline | 2000 |
The effects of acute falciparum malaria on the disposition of caffeine and the comparison of saliva and plasma-derived pharmacokinetic parameters in adult Nigerians.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Animals; Caffeine; Child; Cytochrome P-450 CYP1A2; Female; Humans; Malaria, Falciparum; Male; Metabolic Clearance Rate; Nigeria; Saliva; Theophylline | 2000 |
In vivo effect of clarithromycin on multiple cytochrome P450s.
Topics: Adult; Anti-Bacterial Agents; Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Clarithromycin; Cross-Over Studies; Cytochrome P-450 Enzyme System; Female; Humans; Male; Theophylline; Tolbutamide | 2001 |
Urinary biomarkers for assessing dietary exposure to caffeine.
Topics: Adult; Arylamine N-Acetyltransferase; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Diet; Female; Humans; Liver; Male; Middle Aged; Phenotype; Theophylline; Time Factors; Uric Acid; Xanthines | 2001 |
Effect of a divided caffeine dose on endurance cycling performance, postexercise urinary caffeine concentration, and plasma paraxanthine.
Topics: Adult; Bicycling; Caffeine; Double-Blind Method; Drug Administration Schedule; Humans; Male; Osmolar Concentration; Physical Endurance; Theophylline | 2003 |
Two novel methods for the determination of CYP1A2 activity using the paraxanthine/caffeine ratio.
Topics: Adult; Area Under Curve; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Theophylline | 2003 |
Metabolic effects of caffeine in humans: lipid oxidation or futile cycling?
Topics: Adrenergic beta-Antagonists; Adult; Caffeine; Central Nervous System Stimulants; Energy Metabolism; Humans; Lipid Metabolism; Lipolysis; Male; Oxidation-Reduction; Propranolol; Theophylline | 2004 |
Salivary caffeine metabolic ratio in alcohol-dependent subjects.
Topics: Alcoholism; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Genotype; Humans; Liver Diseases; Liver Function Tests; Male; Saliva; Smoking; Theophylline | 2004 |
Serum metabolite/caffeine ratios as a test for liver function.
Topics: Adult; Caffeine; Female; Hepatitis, Chronic; Humans; Liver; Liver Cirrhosis; Liver Function Tests; Male; Metabolic Clearance Rate; Middle Aged; Theobromine; Theophylline | 2004 |
Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine.
Topics: Administration, Inhalation; Administration, Oral; Biological Availability; Caffeine; Central Nervous System Stimulants; Drug Combinations; Drug Interactions; Half-Life; Heroin; Heroin Dependence; Humans; Injections, Intravenous; Methadone; Narcotics; Population; Theobromine; Theophylline | 2005 |
Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Area Under Curve; Caffeine; Clonidine; Contraceptives, Oral, Combined; Cytochrome P-450 CYP1A2 Inhibitors; Drug Synergism; Ethinyl Estradiol; Female; Half-Life; Humans; Norpregnenes; Theophylline | 2005 |
Liver disease selectively modulates cytochrome P450--mediated metabolism.
Topics: Administration, Oral; Adult; Anticonvulsants; Antihypertensive Agents; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Isoenzymes; Liver Diseases; Male; Mephenytoin; Middle Aged; Muscle Relaxants, Central; Phosphodiesterase Inhibitors; Severity of Illness Index; Theophylline | 2006 |
Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine.
Topics: Adrenergic alpha-Agonists; Adult; Area Under Curve; Blood Pressure; Body Weight; Caffeine; Clonidine; Cytochrome P-450 CYP1A2; Drug Interactions; Female; Half-Life; Humans; Male; Sex Factors; Sleep Stages; Smoking; Theophylline | 2008 |
Caffeine and paraxanthine HPLC assay for CYP1A2 phenotype assessment using saliva and plasma.
Topics: Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Drug Stability; Humans; Least-Squares Analysis; Male; Phenotype; Reproducibility of Results; Saliva; Sensitivity and Specificity; Theophylline; Young Adult | 2010 |
Pharmacokinetics of caffeine in plasma and saliva, and the influence of caffeine abstinence on CYP1A2 metrics.
Topics: Adult; Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Clinical Enzyme Tests; Cross-Over Studies; Cytochrome P-450 CYP1A2; Humans; Inactivation, Metabolic; Male; Metabolic Clearance Rate; Reference Values; Saliva; Theophylline; Young Adult | 2011 |
Cytochrome P450 2A6 phenotyping based on dietary caffeine intake in a Japanese population of non-smokers.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP2A6; Female; Gene Deletion; Genotype; Humans; Japan; Male; Phenotype; Pilot Projects; Theophylline; Uric Acid; Xanthines; Young Adult | 2012 |
Multiple dosing of ephedra-free dietary supplements: hemodynamic, electrocardiographic, and bacterial contamination effects.
Topics: Adult; Bacillus; Blood Pressure; Caffeine; Cross-Over Studies; Dietary Supplements; Drug Contamination; Electrocardiography; Heart Rate; Humans; Male; Theophylline | 2013 |
The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects.
Topics: Adolescent; Adult; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Nitriles; Omeprazole; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Theophylline; Warfarin; Young Adult | 2014 |
The Effect of Caffeine Ingestion during Evening Exercise on Subsequent Sleep Quality in Females.
Topics: Adult; Caffeine; Contraceptives, Oral; Cross-Over Studies; Double-Blind Method; Exercise; Exercise Test; Female; Humans; Sleep; Theobromine; Theophylline; Young Adult | 2015 |
Pregnancy-induced changes in the pharmacokinetics of caffeine and its metabolites.
Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Pregnancy; Pregnancy Trimesters; Theobromine; Theophylline; Young Adult | 2016 |
Establishing population distribution of drug-metabolizing enzyme activities for the use of salivary caffeine as a dynamic liver function marker in a Singaporean Chinese population.
Topics: Adult; Asian People; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Liver; Male; Middle Aged; Saliva; Theophylline; Young Adult | 2016 |
A Phase 1 Open-Label, Fixed-Sequence Pharmacokinetic Drug Interaction Trial to Investigate the Effect of Cannabidiol on the CYP1A2 Probe Caffeine in Healthy Subjects.
Topics: Adult; Anticonvulsants; Caffeine; Cannabidiol; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Female; Humans; Male; Theophylline; Young Adult | 2021 |
200 other study(ies) available for 1,7-dimethylxanthine and caffeine
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids.
Topics: Carbon-Nitrogen Ligases; Enzyme Inhibitors; Escherichia coli; Kinetics; Methylation; Structure-Activity Relationship; Uric Acid; Xanthines | 2010 |
Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1.
Topics: Biotransformation; Caffeine; Cloning, Molecular; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; DNA; Gene Expression; Humans; Oxidoreductases; Oxidoreductases, N-Demethylating; Theobromine; Theophylline; Vaccinia virus | 1992 |
A simple useful method for the determination of hepatic function in patients with liver cirrhosis using caffeine and its three major dimethylmetabolites.
Topics: Adult; Caffeine; Evaluation Studies as Topic; Female; Humans; Liver; Liver Cirrhosis; Male; Methods; Middle Aged; Oxidation-Reduction; Theobromine; Theophylline | 1992 |
Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro.
Topics: 4-Quinolones; Anti-Infective Agents; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Microsomes, Liver; Oxidoreductases; Theophylline | 1992 |
Methylxanthine levels in breast milk of lactating women of different ethnic and socioeconomic classes.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Diet Records; Educational Status; Female; Hispanic or Latino; Humans; Milk, Human; Socioeconomic Factors; Theobromine; Theophylline; White People | 1992 |
Theophylline metabolism affected by mexiletine.
Topics: Adult; Caffeine; Humans; Male; Mexiletine; Theophylline; Uric Acid; Xanthines | 1992 |
Simultaneous determination of caffeine and its primary demethylated metabolites in human plasma by high-performance liquid chromatography.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Humans; Male; Middle Aged; Theobromine; Theophylline | 1992 |
Determination of theophylline in serum and saliva in the presence of caffeine and its metabolites.
Topics: Caffeine; Chromatography, High Pressure Liquid; Drug Interactions; Humans; Saliva; Theophylline | 1991 |
High-performance liquid chromatographic separation of caffeine, theophylline, theobromine and paraxanthine in rat brain and serum.
Topics: Animals; Brain Chemistry; Caffeine; Chromatography, High Pressure Liquid; Male; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Theobromine; Theophylline | 1991 |
Postsynaptic dopamine/adenosine interaction: II. Postsynaptic dopamine agonism and adenosine antagonism of methylxanthines in short-term reserpinized mice.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bromocriptine; Caffeine; Dopamine; Male; Mice; Motor Activity; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reserpine; Sulpiride; Synapses; Theophylline; Xanthines | 1991 |
Caffeine and theophylline as adenosine receptor antagonists in humans.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adult; Caffeine; Heart Rate; Humans; Male; Platelet Aggregation; Purinergic Antagonists; Receptors, Purinergic; Substance Withdrawal Syndrome; Theophylline | 1991 |
Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity.
Topics: Caffeine; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; In Vitro Techniques; Mitosis; Theobromine; Theophylline; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Xanthines | 1990 |
Paraxanthine displaces the binding of [3H]SCH 23390 from rat striatal membranes.
Topics: Animals; Benzazepines; Binding, Competitive; Brain; Caffeine; Corpus Striatum; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Membranes; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Theophylline | 1990 |
HPLC analysis of methylxanthines in human breast milk.
Topics: Caffeine; Chromatography, High Pressure Liquid; Female; Humans; Milk, Human; Temperature; Theobromine; Theophylline; Xanthines | 1990 |
Simpler measurement of caffeine and paraxanthine in saliva.
Topics: Autoanalysis; Caffeine; Humans; Saliva; Theophylline | 1990 |
Effect of chronic caffeine administration on theophylline concentrations required to produce seizures in rats.
Topics: Animals; Caffeine; Drug Interactions; Drug Tolerance; Kinetics; Male; Rats; Rats, Inbred Lew; Seizures; Theobromine; Theophylline | 1990 |
Effect of paraxanthine on FFA mobilization after intravenous caffeine administration in humans.
Topics: Adult; Caffeine; Fatty Acids, Nonesterified; Glycerol; Humans; Injections, Intravenous; Lipid Mobilization; Lipolysis; Male; Theophylline | 1990 |
Human N-acetylation genotype determination with urinary caffeine metabolites.
Topics: Acetylation; Caffeine; Chromatography, High Pressure Liquid; Gene Frequency; Genetics, Population; Genotype; Humans; Nitrogen; Pedigree; Phenotype; Theophylline; Time Factors; Uracil; Uric Acid; Xanthines | 1990 |
Determination of carcinogenic arylamine N-oxidation phenotype in humans by analysis of caffeine urinary metabolites.
Topics: Acetylation; Arylamine N-Acetyltransferase; Biotransformation; Caffeine; Cytochrome P-450 Enzyme System; Disease Susceptibility; Humans; Isoenzymes; Oxidation-Reduction; Phenotype; Theophylline; Uracil; Urinary Bladder Neoplasms; Xanthines | 1990 |
The mechanism of caffeine-enhanced glucose stimulation of liver glycogen synthase phosphatase activity.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Drug Interactions; Glucose; Glucose-6-Phosphate; Glucosephosphates; Liver; Male; Phosphoprotein Phosphatases; Rats; Structure-Activity Relationship; Theobromine; Theophylline; Time Factors; Xanthine; Xanthines | 1986 |
Discriminative stimulus properties of caffeine in the rat: noradrenergic mediation.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adrenergic alpha-Antagonists; Animals; Apomorphine; Avoidance Learning; Caffeine; Clonidine; Diazepam; Discrimination Learning; Male; Norepinephrine; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1986 |
The pharmacokinetics of caffeine and its dimethylxanthine metabolites in patients with chronic liver disease.
Topics: Adult; Aged; Caffeine; Female; Half-Life; Humans; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Saliva; Theobromine; Theophylline | 1989 |
Excretion and metabolism of a series of xanthines by the turtle Pseudemys scripta elegans.
Topics: Animals; Caffeine; Theobromine; Theophylline; Turtles; Uric Acid; Xanthine; Xanthines | 1989 |
Interaction between oral ciprofloxacin and caffeine in normal volunteers.
Topics: Adult; Caffeine; Ciprofloxacin; Drug Interactions; Half-Life; Humans; Male; Theophylline | 1989 |
Paraxanthine metabolism in humans: determination of metabolic partial clearances and effects of allopurinol and cimetidine.
Topics: Acetylation; Adult; Allopurinol; Caffeine; Cimetidine; Cytochrome P-450 Enzyme System; Humans; Kidney; Male; Metabolic Clearance Rate; Theophylline | 1989 |
Correlation of caffeine elimination and Child's classification in liver cirrhosis.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Caffeine; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Liver Cirrhosis; Male; Middle Aged; Theobromine; Theophylline | 1989 |
[Pharmacokinetics of caffeine and dimethylxanthines in plasma and saliva].
Topics: Adult; Caffeine; Female; Humans; Male; Middle Aged; Models, Biological; Pregnancy; Saliva; Theophylline | 1988 |
Caffeine disposition in the pregnant rabbit. I. Pharmacokinetics following administration by intravenous bolus and continuous zero-order infusion.
Topics: Animals; Caffeine; Female; Infusion Pumps; Infusions, Intravenous; Kinetics; Male; Pregnancy; Pregnancy, Animal; Rabbits; Theophylline; Time Factors | 1988 |
Caffeine disposition in the pregnant rabbit. II. Fetal distribution of caffeine and paraxanthine during chronic maternal caffeine administration.
Topics: Albumins; Amniotic Fluid; Animals; Caffeine; Female; Fetal Proteins; Fetus; Infusions, Intravenous; Male; Maternal-Fetal Exchange; Pregnancy; Pregnancy, Animal; Protein Binding; Rabbits; Serum Albumin; Theophylline; Tissue Distribution | 1988 |
Caffeine and paraxanthine pharmacokinetics in the rabbit: concentration and product inhibition effects.
Topics: Animals; Caffeine; Female; Half-Life; Kinetics; Protein Binding; Rabbits; Theophylline; Ultrafiltration | 1987 |
Inherent differences in sensitivity to methylxanthines among inbred mice.
Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Drug Resistance; Mice; Mice, Inbred Strains; Motor Activity; Species Specificity; Theobromine; Theophylline; Time Factors; Xanthines | 1986 |
Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man.
Topics: Adult; Caffeine; Humans; Kinetics; Male; Theobromine; Theophylline | 1986 |
Quantitative assessment of caffeine partial clearances in man.
Topics: Adult; Caffeine; Humans; Kinetics; Male; Theobromine; Theophylline | 1986 |
Simple and sensitive method for the simultaneous determination of enprofylline, theobromine, paraxanthine, theophylline and caffeine using high-performance liquid chromatography.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Theobromine; Theophylline; Xanthines | 1986 |
Urinary metabolites of caffeine in pregnant women.
Topics: Caffeine; Female; Humans; Pregnancy; Theophylline; Uric Acid; Xanthines | 1986 |
Teratogenicity of paraxanthine (1,7-dimethylxanthine) in C57BL/6J mice.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cleft Palate; Dose-Response Relationship, Drug; Female; Limb Deformities, Congenital; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Pregnancy; Theobromine; Theophylline | 1986 |
Discriminative stimulus properties of methylxanthines and their metabolites in rats.
Topics: Animals; Caffeine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines | 1985 |
High-performance liquid chromatographic determination of dimethylxanthine metabolites of caffeine in human plasma.
Topics: Ammonium Sulfate; Caffeine; Chromatography, High Pressure Liquid; Humans; Liver Diseases; Theobromine; Theophylline | 1985 |
The effect of caffeine ingestion on pharmacokinetics of caffeine and its metabolites after a single administration in pregnant rats.
Topics: Administration, Oral; Animals; Caffeine; Female; Injections, Intravenous; Kinetics; Pregnancy; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1985 |
Improved high-performance liquid chromatographic method for the simultaneous determination of caffeine and its N-demethylated metabolites in plasma using solid-phase extraction.
Topics: Caffeine; Chromatography, High Pressure Liquid; Dealkylation; Humans; Serum Albumin, Bovine; Theobromine; Theophylline; Xanthines | 1985 |
Two high-performance liquid chromatographic methods for quantitation of theophylline in plasma.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Spectrophotometry, Ultraviolet; Theobromine; Theophylline | 1985 |
Caffeine disposition after oral administration to pregnant rats.
Topics: Administration, Oral; Amniotic Fluid; Animals; Caffeine; Female; Fetus; Pregnancy; Rats; Theobromine; Theophylline; Time Factors | 1985 |
Evaluation of caffeine plasma levels by an automated enzyme immunoassay (EMIT) in comparison with a high-performance liquid chromatographic method.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Liver Diseases; Reagent Kits, Diagnostic; Theophylline | 1984 |
Potentiating effects of methylxanthines on teratogenicity of mitomycin C in mice.
Topics: Abnormalities, Drug-Induced; Animals; Antibiotics, Antineoplastic; Caffeine; Drug Synergism; Female; Mice; Mice, Inbred ICR; Mitomycin; Mitomycins; Pregnancy; Structure-Activity Relationship; Theobromine; Theophylline; Xanthines | 1983 |
Caffeine and its dimethylxanthines and fetal cerebral development in rat.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Caffeine; Female; Fetus; Maternal-Fetal Exchange; Pregnancy; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines | 1984 |
Differences in steady-state plasma levels between aminophylline and theophylline sustained-release micropellets after repeated circadian dosing.
Topics: Absorption; Administration, Oral; Adult; Aminophylline; Biological Availability; Caffeine; Chromatography, High Pressure Liquid; Circadian Rhythm; Delayed-Action Preparations; Double-Blind Method; Humans; Kinetics; Male; Random Allocation; Theophylline | 1984 |
Improved micro-method for the high-performance liquid chromatographic determination of caffeine and paraxanthine in biological fluids.
Topics: Animals; Body Fluids; Caffeine; Chromatography, High Pressure Liquid; Female; Fetal Blood; Pregnancy; Rabbits; Solvents; Spectrophotometry, Ultraviolet; Theophylline | 1984 |
Simultaneous determination of caffeine and its N-demethylated metabolites in umbilical cord plasma using high-performance liquid chromatography.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Dealkylation; Female; Fetal Blood; Humans; Infant; Theobromine; Theophylline | 1984 |
Disposition of caffeine and its metabolites in man.
Topics: Adult; Biotransformation; Caffeine; Female; Humans; Kinetics; Male; Theobromine; Theophylline | 1983 |
Sister chromatid exchanges induced by methylxanthines contained in coffee, tea and cocoa.
Topics: Animals; Bone Marrow; Caffeine; Coca; Coffee; Cricetinae; Cricetulus; Crossing Over, Genetic; Plants, Medicinal; Sister Chromatid Exchange; Tea; Theobromine; Theophylline; Xanthines | 1982 |
Improved high-performance liquid chromatographic assay for theophylline in plasma and saliva in the presence of caffeine and its metabolites and comparisons with three other assays.
Topics: Caffeine; Chromatography, High Pressure Liquid; Coffee; Humans; Saliva; Theophylline | 1982 |
Reversed-phase liquid chromatographic investigation of UV-absorbing low-molecular-weight compounds in saliva.
Topics: Caffeine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Molecular Weight; Saliva; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Time Factors | 1982 |
Urinary excretion of an uracilic metabolite from caffeine by rat, monkey and man.
Topics: Adult; Animals; Biotransformation; Caffeine; Humans; Macaca fascicularis; Male; Rats; Species Specificity; Theobromine; Theophylline; Uracil; Uric Acid; Xanthines | 1981 |
Determination of plasma theophylline by straight-phase high-performance liquid chromatography: elimination of interfering caffeine metabolites.
Topics: Beverages; Caffeine; Chromatography, High Pressure Liquid; Humans; Microchemistry; Theophylline | 1981 |
Reversed-phase high-performance liquid chromatographic determination of caffeine and its N-demethylated metabolites in dog plasma.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Dogs; Male; Reference Values; Theobromine; Theophylline; Time Factors | 1981 |
Metabolism of theophylline to caffeine in adults.
Topics: Adult; Biotransformation; Caffeine; Humans; Kinetics; Male; Mathematics; Theophylline | 1981 |
Separation and quantitation of theophylline and paraxanthine by reversed-phase liquid chromatography.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Quaternary Ammonium Compounds; Theophylline | 1980 |
Analysis of within-subject variation of caffeine metabolism when used to determine cytochrome P4501A2 and N-acetyltransferase-2 activities.
Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Female; Genetic Variation; Humans; Male; Middle Aged; Oxidoreductases; Phenotype; Spectrophotometry, Ultraviolet; Theophylline; Time Factors; Uracil; Xanthines | 1995 |
Microdialysis sampling coupled on-line to fast microbore liquid chromatography.
Topics: Acetaminophen; Animals; Caffeine; Chromatography, High Pressure Liquid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Theobromine; Theophylline | 1995 |
Paraxanthine (metabolite of caffeine) mimics caffeine's interaction with sympathetic control of thermogenesis.
Topics: Adipose Tissue, Brown; Animals; Body Temperature Regulation; Caffeine; Drug Combinations; Ephedrine; Male; Osmolar Concentration; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Theophylline | 1994 |
Segregation analyses of four urinary caffeine metabolite ratios implicated in the determination of human acetylation phenotypes.
Topics: Acetylation; Adolescent; Adult; Alleles; Arylamine N-Acetyltransferase; Caffeine; Child; Chromatography, High Pressure Liquid; Family; Female; Gene Frequency; Genes, Recessive; Humans; Male; Middle Aged; Models, Genetic; Models, Statistical; Phenotype; Polymorphism, Genetic; Theophylline; Uracil; Uric Acid; Xanthines | 1994 |
Metabolism of caffeine and theophylline in rats with malaria and endotoxin-induced fever.
Topics: Administration, Oral; Animals; Caffeine; Endotoxins; Fever; Injections, Intravenous; Malaria; Male; Metabolic Clearance Rate; Plasmodium berghei; Rats; Rats, Wistar; Theobromine; Theophylline | 1993 |
Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breath Tests; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Humans; Male; Mephenytoin; Middle Aged; Omeprazole; Oxidoreductases, N-Demethylating; Phenotype; Theophylline; Uric Acid | 1994 |
Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms.
Topics: Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Microsomes, Liver; Oxidoreductases; Theobromine; Theophylline; Uric Acid | 1994 |
Accumulation of theophylline, theobromine and paraxanthine in the fetal rat brain following a single oral dose of caffeine.
Topics: Animals; Biotransformation; Brain; Caffeine; Chromatography, High Pressure Liquid; Female; Pregnancy; Rats; Rats, Wistar; Theobromine; Theophylline; Xanthines | 1993 |
Comparison of hepatic drug-oxidizing activity after simultaneous administration of two probe drugs, caffeine and trimethadione, to human subjects.
Topics: Adult; Caffeine; Cytochrome P-450 Enzyme System; Drug Combinations; Drug Interactions; Half-Life; Humans; Liver; Male; Middle Aged; Oxidation-Reduction; Oxygenases; Theobromine; Theophylline; Trimethadione | 1993 |
Excretion of caffeine and its primary degradation products into bile.
Topics: Adult; Aged; Bile; Bilirubin; Caffeine; Chromatography, High Pressure Liquid; Female; Humans; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Theobromine; Theophylline; Time Factors | 1993 |
Changes in the metabolism of three model substrates catalysed by different P450 isozymes when administered as a cocktail to the carbon tetrachloride-intoxicated rat.
Topics: Animals; Biotransformation; Caffeine; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Hydantoins; Injections, Intravenous; Isoenzymes; Lidocaine; Male; Phenytoin; Rats; Rats, Sprague-Dawley; Theophylline | 1995 |
Pharmacokinetics of caffeine in the oestrogen-implanted ovariectomized ewe.
Topics: Animals; Area Under Curve; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Implants; Estradiol; Estrus Synchronization; Female; Half-Life; Injections, Intravenous; Ovariectomy; Sheep; Theobromine; Theophylline | 1996 |
Assessment of dimethylxanthine formation from caffeine in healthy adults: comparison between plasma and saliva concentrations and urinary excretion of metabolites.
Topics: Adult; Caffeine; Female; Humans; Male; Saliva; Theobromine; Theophylline | 1996 |
Cytochrome P4501A2: enzyme induction and genetic control in determining 4-aminobiphenyl-hemoglobin adduct levels.
Topics: Age Factors; Alcohol Drinking; Aminobiphenyl Compounds; Arylamine N-Acetyltransferase; Caffeine; Carcinogens; Coffee; Cytochrome P-450 CYP1A2; DNA Adducts; Drinking; Enzyme Induction; Glutathione Transferase; Hemoglobins; Humans; Male; Meat; Middle Aged; Nicotiana; Oxidation-Reduction; Phenotype; Plants, Toxic; Polymorphism, Genetic; Risk Factors; Smoking; Theophylline; Uric Acid; Urinary Bladder Neoplasms | 1996 |
Theoretical relationship between the post-administration time and plasma or urinary concentration of a metabolite and the unchanged drug. Administration of caffeine to horses.
Topics: Animals; Caffeine; Horses; Substance Abuse Detection; Theophylline | 1996 |
Use of 3-(1,8-naphthalimido)propyl-modified silyl silica gel as a stationary phase for the high-performance liquid chromatographic separation of purine derivatives.
Topics: 1-Naphthylamine; Adult; Beverages; Caffeine; Chromatography, High Pressure Liquid; Female; Humans; Indicators and Reagents; Male; Purines; Silica Gel; Silicon Dioxide; Spectrophotometry, Ultraviolet; Tablets; Theophylline | 1996 |
Isotopic effects on retention times of caffeine and its metabolites 1,3,7-trimethyluric acid, theophylline, theobromine and paraxanthine.
Topics: Animals; Caffeine; Deuterium; Gas Chromatography-Mass Spectrometry; Isotope Labeling; Kidney; Male; Rats; Rats, Wistar; Theobromine; Theophylline; Uric Acid | 1997 |
Determination of caffeine and its metabolites by micellar electrokinetic capillary electrophoresis.
Topics: Animals; Beverages; Buffers; Caffeine; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Rats; Sodium Dodecyl Sulfate; Tablets; Theobromine; Theophylline; Uric Acid | 1997 |
[Development of syringe-type off line pre-column and simultaneous quantitation of four xanthine derivatives (caffeine, theobromine, theophylline and paraxanthine) in serum].
Topics: Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Humans; Theobromine; Theophylline; Xanthines | 1997 |
Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations.
Topics: Aged; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Female; Genotype; Humans; In Vitro Techniques; Liver; Male; Metabolic Clearance Rate; Middle Aged; Phenotype; Saliva; Theophylline | 1996 |
Comparative pharmacokinetics of caffeine and three metabolites in clinically normal horses and donkeys.
Topics: Animals; Caffeine; Equidae; Female; Horses; Male; Metabolic Clearance Rate; Species Specificity; Theobromine; Theophylline; Time Factors | 1997 |
Differences in caffeine 3-demethylation activity among inbred mouse strains: a comparison of hepatic Cyp1a2 gene expression between two inbred strains.
Topics: Acetaminophen; Animals; Caffeine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; DNA, Complementary; Female; Gene Expression Regulation, Enzymologic; Immunoblotting; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Oligonucleotide Probes; Phenotype; RNA, Messenger; Sex Factors; Theophylline | 1997 |
Serum caffeine and paraxanthine as markers for reported caffeine intake in pregnancy.
Topics: Biomarkers; Blood Specimen Collection; Caffeine; Cohort Studies; Diet; Female; Humans; Mental Recall; Pregnancy; Reproducibility of Results; Theophylline | 1998 |
Simple high-performance liquid chromatography method for the simultaneous determination of serum caffeine and paraxanthine following rapid sample preparation.
Topics: Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Perchlorates; Quality Control; Reproducibility of Results; Spectrophotometry, Ultraviolet; Theophylline | 1998 |
Isolation of lipolytic substances caffeine and 1,7-dimethylxanthine from the stem and rhizome of Sinomenium actum.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Lipolysis; Male; Medicine, Chinese Traditional; Plant Stems; Plants, Medicinal; Rats; Rats, Wistar; Theophylline | 1998 |
Effect of toluidines and dinitrotoluenes on caffeine metabolic ratio in rat.
Topics: Animals; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Dealkylation; Dinitrobenzenes; Male; Rats; Rats, Wistar; Theobromine; Theophylline; Toluidines | 1999 |
Five caffeine metabolite ratios to measure tobacco-induced CYP1A2 activity and their relationships with urinary mutagenicity and urine flow.
Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Environmental Exposure; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mutagens; Rheology; Smoking; Theophylline; Time Factors; Uracil; Uric Acid; Urination; Xanthines | 1999 |
Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test.
Topics: Adult; Anthropometry; Caffeine; Coffee; Contraceptives, Oral; Cytochrome P-450 CYP1A2; Female; Humans; Male; Reference Values; Saliva; Smoking; Theophylline; White People | 1999 |
Validation of a high-performance liquid chromatography assay for quantification of caffeine and paraxanthine in human serum in the context of CYP1A2 phenotyping.
Topics: Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Phenotype; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Theophylline | 1999 |
Chronic effects of xanthines on levels of central receptors in mice.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Chemistry; Caffeine; Calcium Channels; Central Nervous System Stimulants; Cerebral Cortex; Corpus Striatum; Drug Interactions; Gene Expression Regulation; Male; Mice; Nerve Tissue Proteins; Pentoxifylline; Radioligand Assay; Receptors, Cholinergic; Receptors, Drug; Receptors, GABA; Receptors, Purinergic P1; Receptors, Serotonin; Theobromine; Theophylline; Xanthines | 1999 |
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.
Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Glucuronidase; Humans; Indicators and Reagents; Midazolam; Reproducibility of Results; Sensitivity and Specificity; Substrate Specificity; Theophylline | 1999 |
Detection of quantitative trait loci affecting caffeine metabolism by interval mapping in a genome-wide scan of C3H/HeJ x APN F(2) mice.
Topics: Animals; Breeding; Caffeine; Chromosome Mapping; Cytochrome P-450 CYP1A2; Female; Genetic Markers; Genotype; Male; Mice; Mice, Inbred C3H; Multifactorial Inheritance; Phenotype; Quantitative Trait, Heritable; Sex Factors; Theophylline | 1999 |
Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion.
Topics: Abortion, Spontaneous; Adult; Caffeine; Case-Control Studies; Female; Humans; Odds Ratio; Pregnancy; Retrospective Studies; Risk Factors; Theophylline | 1999 |
Caffeine--filtering the facts.
Topics: Abortion, Spontaneous; Breast Feeding; Caffeine; Child Development; Female; Fetus; Humans; Infant; Pregnancy; Theophylline | 1999 |
Differential activities of CYP1A isozymes in hepatic and intestinal microsomes of control and 3-methylcholanthrene-induced rats.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Induction; Enzyme Inhibitors; Injections, Intraperitoneal; Intestine, Small; Ketoconazole; Liver; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Wistar; Theobromine; Theophylline | 2000 |
Caffeine consumption and the risk of spontaneous abortions.
Topics: Abortion, Spontaneous; Caffeine; Case-Control Studies; Female; Humans; Pregnancy; Reproducibility of Results; Retrospective Studies; Risk Factors; Smoking; Theophylline | 2000 |
Parkinson's disease and CYP1A2 activity.
Topics: Adult; Aged; Aged, 80 and over; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Parkinson Disease; Reproducibility of Results; Saliva; Theophylline | 2000 |
In vivo modulation of CYP enzymes by quinidine and rifampin.
Topics: Acetylation; Administration, Oral; Adrenergic alpha-Antagonists; Adult; Anti-Arrhythmia Agents; Antibiotics, Antitubercular; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Administration Schedule; Enzyme Inhibitors; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Quinidine; Reference Values; Rifampin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline | 2000 |
Paraxanthine, a caffeine metabolite, dose dependently increases [Ca(2+)](i) in skeletal muscle.
Topics: Animals; Caffeine; Calcium; Dose-Response Relationship, Drug; Hindlimb; In Vitro Techniques; Intracellular Membranes; Male; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Osmolar Concentration; Procaine; Theobromine; Theophylline | 2000 |
Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals: analysis of its potential role in heavy alcohol drinking tumor-promoting effects.
Topics: Acetaldehyde; Alcohol Drinking; Allopurinol; Animals; Antimetabolites; Caffeine; Carcinogens; Chromatography, Gas; Cytosol; Diet; Enzyme Inhibitors; Ethanol; Free Radicals; Gas Chromatography-Mass Spectrometry; Hypoxanthine; Male; Meat; NAD; Neoplasms; Niacinamide; Phosphodiesterase Inhibitors; Prostate; Prostatic Neoplasms; Purines; Rats; Rats, Sprague-Dawley; Spin Trapping; Temperature; Theobromine; Theophylline; Time Factors; Vasodilator Agents; Xanthine; Xanthine Oxidase | 2001 |
Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells.
Topics: Adenosine; Animals; Caffeine; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Inosine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theobromine; Theophylline; Transfection | 2001 |
[Use of the paraxanthine/caffeine ratio in the saliva of patients with liver cirrhosis].
Topics: Caffeine; Female; Humans; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Saliva; Theophylline | 2001 |
In vivo inhibition of human CYP1A2 activity by oltipraz.
Topics: Adult; Antineoplastic Agents; Caffeine; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Female; Humans; Male; Methylation; Pyrazines; Theophylline; Thiones; Thiophenes | 2001 |
[Determination of caffeine metabolite for the evaluation of N-acetyltransferase, CYP1A2 and xanthine oxidase activities].
Topics: Adolescent; Adult; Aged; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines | 1997 |
[HPLC determination of five caffeine metabolites].
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Theophylline; Uracil; Uric Acid; Xanthines | 1997 |
Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment.
Topics: Adult; Albumins; Blood Flow Velocity; Blood Glucose; Blood Volume; Brachial Artery; Caffeine; Capillaries; Female; Glucose; Humans; Insulin; Lactic Acid; Male; Muscle, Skeletal; Oxygen Consumption; Theophylline; Xanthines | 2001 |
Variability of cytochrome P450 1A2 activity over time in young and elderly healthy volunteers.
Topics: Adult; Age Factors; Aged; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Female; Humans; Male; Theophylline; Time Factors | 2001 |
Maternal serum caffeine metabolites and small-for-gestational age birth.
Topics: Adult; Analysis of Variance; Caffeine; Chi-Square Distribution; Female; Humans; Infant, Newborn; Infant, Small for Gestational Age; Logistic Models; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, Third; Risk Factors; Smoking; Theophylline | 2002 |
CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk.
Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Colorectal Neoplasms; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Phenotype; Risk Factors; Theophylline; Uric Acid | 2002 |
Differences in caffeine and paraxanthine metabolism between human and murine CYP1A2.
Topics: Animals; Caffeine; Cytochrome P-450 CYP1A2; Humans; Mice; Phosphodiesterase Inhibitors; Species Specificity; Theophylline | 2002 |
Caffeine potentiates the discriminative-stimulus effects of nicotine in rats.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Differential Threshold; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Ganglionic Stimulants; Generalization, Stimulus; Male; Motor Activity; Nicotine; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Theobromine; Theophylline; Vasodilator Agents | 2002 |
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction.
Topics: Adult; Breath Tests; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Environmental Pollutants; Enzyme Induction; Female; Humans; Liver; Male; Methylation; Polychlorinated Dibenzodioxins; Smoking; Teratogens; Theophylline; Uracil; Uric Acid; Xanthines | 2002 |
[Research on the separation of caffeine and its nine analogues by micellar electrokinetic capillary chromatography].
Topics: Buffers; Caffeine; Chromatography, Micellar Electrokinetic Capillary; Hydrogen-Ion Concentration; Theophylline; Xanthines | 2002 |
Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Cerebral Cortex; Horses; Male; Neostriatum; Prosencephalon; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theobromine; Theophylline | 2003 |
Effect of naturally occurring plant phenolics on the induction of drug metabolizing enzymes by o-toluidine.
Topics: Animals; Biotransformation; Caffeine; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ellagic Acid; Enzyme Induction; Glutathione Transferase; Hydrolyzable Tannins; Hydroxybenzoates; Kidney; Liver; Male; Oxidoreductases; Rats; Rats, Wistar; Theobromine; Theophylline; Toluidines | 2003 |
Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Asian People; Aspirin; Caffeine; China; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Isoenzymes; Male; Mephenytoin; Metoprolol; Midazolam; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenotype; Reference Values; Theophylline | 2003 |
Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans.
Topics: Animals; Blotting, Western; Caffeine; Carcinogens; Cytochrome P-450 CYP1A2; Dietary Supplements; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Male; Microsomes, Liver; Obesity; Plant Extracts; Rats; Rats, Sprague-Dawley; Smoking; Theophylline | 2003 |
Paraxanthine/caffeine ratio: as an index for CYP1A2 activity in polycyclic aromatic hydrocarbons exposed subjects.
Topics: Adult; Caffeine; Carbon Dioxide; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Female; Humans; Middle Aged; Polycyclic Aromatic Hydrocarbons; Theophylline; Vehicle Emissions | 2003 |
Regarding "An unexpected distribution of sodium concentration in serum specimens stored for more than 30 years".
Topics: Abortion, Spontaneous; Adult; Bias; Caffeine; Female; Humans; Pregnancy; Risk Factors; Sodium; Specimen Handling; Theophylline; Time Factors | 2004 |
Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthine.
Topics: Animals; Caffeine; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Fluoresceins; Humans; Organic Anion Transporters; Theophylline; Xanthines | 2004 |
Caffeine suppresses TNF-alpha production via activation of the cyclic AMP/protein kinase A pathway.
Topics: Adult; Caffeine; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Female; Humans; In Vitro Techniques; Interleukin-1; Interleukin-10; Interleukin-12; Lipopolysaccharides; Theophylline; Tumor Necrosis Factor-alpha | 2004 |
Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Amyotrophic Lateral Sclerosis; Anticonvulsants; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Riluzole; Theophylline | 2005 |
Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Escherichia coli; Female; Genotype; Humans; Hydroxylation; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Theophylline | 2005 |
Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans.
Topics: Adult; Antimalarials; Antinematodal Agents; Area Under Curve; Artemisinins; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Humans; Male; Mass Spectrometry; Middle Aged; Theophylline; Thiabendazole | 2005 |
Caffeine metabolites in umbilical cord blood, cytochrome P-450 1A2 activity, and intrauterine growth restriction.
Topics: Adult; Biomarkers; Caffeine; Chi-Square Distribution; Connecticut; Cytochrome P-450 Enzyme System; Female; Fetal Blood; Fetal Growth Retardation; Humans; Massachusetts; Maternal-Fetal Exchange; Mothers; Pregnancy; Pregnancy Outcome; Risk Factors; Statistics, Nonparametric; Theobromine; Theophylline | 2006 |
[Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe].
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Female; Humans; Male; Mixed Function Oxygenases; Theophylline; Uracil; Uric Acid; Xanthines | 2006 |
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Reproducibility of Results; Sensitivity and Specificity; Smoking; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines | 2007 |
Awareness and use of caffeine by athletes competing at the 2005 Ironman Triathlon World Championships.
Topics: Adult; Awareness; Bicycling; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Female; Humans; Male; Physical Endurance; Prevalence; Running; Surveys and Questionnaires; Swimming; Theophylline | 2006 |
Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans.
Topics: Adult; Aging; Brain Injuries; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Ethanol; Female; Glasgow Coma Scale; Glasgow Outcome Scale; Humans; Male; Prospective Studies; Theobromine; Theophylline; Treatment Outcome | 2008 |
Perinatal dioxin exposure, cytochrome P-450 activity, liver functions and thyroid hormones at follow-up after 7-12 years.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Caffeine; Child; Cytochrome P-450 CYP1A2; Dioxins; Environmental Exposure; Environmental Pollutants; Female; Follow-Up Studies; Humans; Lactation; Liver; Male; Maternal-Fetal Exchange; Netherlands; Pregnancy; Theophylline; Thyrotropin; Thyroxine | 2008 |
Growth hormone does not alter CYP2A6 activity in growth hormone-deficient children.
Topics: Adolescent; Aryl Hydrocarbon Hydroxylases; Caffeine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Female; Genotype; Growth Disorders; Human Growth Hormone; Humans; Injections, Subcutaneous; Male; Mixed Function Oxygenases; Recombinant Proteins; Theophylline; Uric Acid | 2008 |
Assessing caffeine exposure in pregnant women.
Topics: Adult; Biomarkers; Caffeine; Diet Records; Feeding Behavior; Female; Humans; Pregnancy; Pregnancy Outcome; Pregnancy Trimesters; Prospective Studies; Saliva; Sensitivity and Specificity; Surveys and Questionnaires; Theophylline | 2008 |
Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels.
Topics: Animals; Apoptosis; Caffeine; Cell Death; Cell Survival; Cells, Cultured; Dopamine; Embryo, Mammalian; Fluorescent Antibody Technique, Indirect; Hydrogen-Ion Concentration; Mesencephalon; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Ryanodine; Ryanodine Receptor Calcium Release Channel; Solubility; Theophylline | 2008 |
CYP2A6 activity in a healthy Spanish population: effect of age, sex, smoking, and oral contraceptives.
Topics: Adolescent; Adult; Age Factors; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Contraceptives, Oral; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Phenotype; Risk Factors; Sex Factors; Smoking; Spain; Theophylline; Uric Acid | 2008 |
Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells.
Topics: Animals; Blotting, Western; Caffeine; Cells, Cultured; Connective Tissue Growth Factor; DNA Primers; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Hepatocytes; Inhibitory Concentration 50; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Regression Analysis; Reverse Transcriptase Polymerase Chain Reaction; Theobromine; Theophylline | 2009 |
Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5.
Topics: Caffeine; Gene Expression; Metabolic Networks and Pathways; Pseudomonas putida; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines | 2009 |
Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population.
Topics: Age Factors; Caffeine; Cytochrome P-450 CYP1A2; Enzyme Induction; Female; Genetic Variation; Genotype; Humans; Linkage Disequilibrium; Male; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Reference Values; Sequence Deletion; Smoking; Theophylline; Turkey | 2009 |
Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers.
Topics: Adolescent; Adult; Caffeine; Cardiovascular Diseases; Cytochrome P-450 CYP1A2; Enzyme Activation; Humans; Male; Phenanthrenes; Theophylline; Time Factors | 2009 |
Drug metabolizing enzyme CYP1A2 status in pediatric patients with hemoglobin E-beta thalassemia.
Topics: beta-Thalassemia; Caffeine; Case-Control Studies; Child; Confidence Intervals; Cytochrome P-450 CYP1A2; Female; Ferritins; Glutathione; Hemoglobin E; Humans; Lipid Peroxides; Liver; Male; Multivariate Analysis; Oxidative Stress; Sex Factors; Thailand; Theophylline; Transaminases | 2009 |
Neuroprotection by caffeine: time course and role of its metabolites in the MPTP model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Caffeine; Corpus Striatum; Dopamine; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease, Secondary; Theophylline; Time Factors | 2010 |
Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic mice.
Topics: Animals; Ataxin-3; Benzhydryl Compounds; Body Temperature; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Female; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Modafinil; Motor Activity; Narcolepsy; Neuropeptides; Nuclear Proteins; Orexins; Sleep; Theophylline; Transcription Factors | 2010 |
A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enoxacin; Humans; Male; Norfloxacin; Reproducibility of Results; Sensitivity and Specificity; Theophylline | 2011 |
Effects of the aqueous extract from Salvia miltiorrhiza Bunge on caffeine pharmacokinetics and liver microsomal CYP1A2 activity in humans and rats.
Topics: Administration, Oral; Animals; Area Under Curve; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochromes; Drugs, Chinese Herbal; Enzyme Inhibitors; Half-Life; Humans; Injections, Intraperitoneal; Liver; Male; Metabolic Clearance Rate; Microsomes, Liver; Plant Roots; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Substrate Specificity; Theophylline | 2010 |
Disposition kinetics of caffeine and paraxanthine in Nile tilapia (Oreochromis niloticus): characterization of the main metabolites.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cichlids; Male; Theophylline; Tissue Distribution; Water Pollutants, Chemical | 2011 |
Pharmacokinetics and metabolism of natural methylxanthines in animal and man.
Topics: Animals; Caffeine; Female; Humans; Male; Metabolic Networks and Pathways; Theobromine; Theophylline; Tissue Distribution; Xanthines | 2011 |
Caffeine and insulin resistance in pregnancy.
Topics: Birth Weight; Caffeine; Female; Homeostasis; Humans; Infant, Newborn; Insulin Resistance; Male; Pregnancy; Theophylline | 2011 |
Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Drug Interactions; Enzyme Induction; Indole Alkaloids; Quinazolines; Rats; Rats, Sprague-Dawley; Theobromine; Theophylline; Vasodilator Agents | 2011 |
Measurements of caffeine and plasma metabolite/caffeine ratios as a test for hepatic drug-oxidizing capacity in goats.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Female; Goats; Liver; Oxidation-Reduction; Reference Standards; Theobromine; Theophylline | 2011 |
Clinical and physiological correlates of caffeine and caffeine metabolites in primary insomnia.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Electroencephalography; Female; Humans; Male; Neuropsychological Tests; Polysomnography; Sleep; Sleep Initiation and Maintenance Disorders; Theophylline | 2011 |
Caffeine as an indicator for the quantification of untreated wastewater in karst systems.
Topics: Biodegradation, Environmental; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Environmental Monitoring; Germany; Groundwater; Seasons; Sewage; Tandem Mass Spectrometry; Theobromine; Theophylline; Water Movements; Water Pollutants, Chemical | 2012 |
High-resolution mass spectrometry method for the detection, characterization and quantitation of pharmaceuticals in water.
Topics: Caffeine; Chromatography, Liquid; Drinking Water; Drug Stability; Linear Models; Pharmaceutical Preparations; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Theophylline; Water Pollutants, Chemical | 2011 |
New specific marker of cytochrome P450 1A2 activity.
Topics: Algorithms; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Humans; Models, Theoretical; Phenotype; Theophylline | 2011 |
High-sensitivity liquid chromatography-tandem mass spectrometry for the simultaneous determination of five drugs and their cytochrome P450-specific probe metabolites in human plasma.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Drug Stability; Humans; Imidazoles; Linear Models; Liquid-Liquid Extraction; Losartan; Omeprazole; Pharmaceutical Preparations; Reproducibility of Results; Tandem Mass Spectrometry; Tetrazoles; Theophylline | 2012 |
Changes in CYP1A2 activity in humans after 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) administration using caffeine as a probe drug.
Topics: Adult; Area Under Curve; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Female; Half-Life; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Sex Factors; Theophylline | 2012 |
Caffeine reduces 11β-hydroxysteroid dehydrogenase type 2 expression in human trophoblast cells through the adenosine A(2B) receptor.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Analysis of Variance; Blotting, Western; Caffeine; Colforsin; Cyclic AMP; DNA Primers; Female; Gene Expression Regulation, Enzymologic; Gene Knockdown Techniques; Humans; In Vitro Techniques; Real-Time Polymerase Chain Reaction; Receptor, Adenosine A2B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Theophylline; Trophoblasts | 2012 |
Association between common CYP1A2 polymorphisms and theophylline metabolism in non-smoking healthy volunteers.
Topics: Adolescent; Asian People; Caffeine; China; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Genotype; Haplotypes; Humans; Male; Polymorphism, Single Nucleotide; Theophylline; Young Adult | 2013 |
Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Humans; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Theophylline | 2013 |
Diurnal variation in CYP1A2 enzyme activity in South Asians and Europeans.
Topics: Adult; Asian People; Caffeine; Circadian Rhythm; Cytochrome P-450 CYP1A2; Female; Humans; Male; Pharmaceutical Preparations; Saliva; Theophylline; White People; Young Adult | 2013 |
Simultaneous in vivo phenotyping of CYP enzymes.
Topics: Caffeine; Cytochrome P-450 Enzyme System; Humans; Liquid-Liquid Extraction; Phenotype; Solid Phase Extraction; Tandem Mass Spectrometry; Theophylline; Time Factors | 2013 |
Simultaneous quantification of caffeine and its three primary metabolites in rat plasma by liquid chromatography-tandem mass spectrometry.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Theobromine; Theophylline | 2013 |
Chronological effects of rifampicin discontinuation on cytochrome P450 activity in healthy Japanese volunteers, using the cocktail method.
Topics: Adult; Antibiotics, Antitubercular; Asian People; Caffeine; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Imidazoles; Losartan; Male; Midazolam; Omeprazole; Rifampin; Tetrazoles; Theophylline; Time Factors; Withholding Treatment | 2013 |
A pharmacometric approach to investigate the impact of methylxanthine abstinence and caffeine consumption on CYP1A2 activity.
Topics: Adult; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Humans; Male; Models, Biological; Theophylline; Xanthines; Young Adult | 2013 |
[Evaluation of pharmacokinetic interaction of aphobazole with CYP1A2 drug-substrate in experiments].
Topics: Administration, Oral; Animals; Animals, Outbred Strains; Anti-Anxiety Agents; Benzimidazoles; Biotransformation; Caffeine; Chromatography, Gas; Cytochrome P-450 CYP1A2; Cytochromes; Drug Administration Schedule; Drug Interactions; Male; Morpholines; Rats; Theobromine; Theophylline | 2013 |
[Effect of Tibetan medicine zuotai on the activity, protein and mRNA expression of CYP1A2 and NAT2].
Topics: Administration, Oral; Animals; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Male; Medicine, Tibetan Traditional; Rats; Rats, Sprague-Dawley; RNA, Messenger; Theophylline; Uracil; Uric Acid; Xanthines | 2014 |
Why dried blood spots are an ideal tool for CYP1A2 phenotyping.
Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Dried Blood Spot Testing; Female; Healthy Volunteers; Humans; Male; Middle Aged; Phenotype; Regression Analysis; Theophylline; Young Adult | 2014 |
CYP1A2 phenotyping in dried blood spots and microvolumes of whole blood and plasma.
Topics: Caffeine; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Humans; Plasma; Reproducibility of Results; Tandem Mass Spectrometry; Theophylline | 2014 |
Comparison of maternal and fetal blood levels of caffeine and its metabolite. A pilot study.
Topics: Adult; Caffeine; Female; Fetal Blood; Humans; Infant, Newborn; Logistic Models; Male; Pilot Projects; Poland; Pregnancy; Theophylline; Young Adult | 2014 |
Potassium-based algorithm allows correction for the hematocrit bias in quantitative analysis of caffeine and its major metabolite in dried blood spots.
Topics: Algorithms; Caffeine; Dried Blood Spot Testing; Hematocrit; Humans; Limit of Detection; Potassium; Theophylline | 2014 |
Associations of ambulatory blood pressure with urinary caffeine and caffeine metabolite excretions.
Topics: Adult; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Caffeine; Circadian Rhythm; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Middle Aged; Prevalence; Theobromine; Theophylline | 2015 |
Paraxanthine/Caffeine Concentration Ratios in Hair: An Alternative for Plasma-Based Phenotyping of Cytochrome P450 1A2?
Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Female; Hair; Humans; Male; Middle Aged; Phenotype; Theophylline; Young Adult | 2015 |
Maternal serum paraxanthine during pregnancy and offspring body mass index at ages 4 and 7 years.
Topics: Adult; Biomarkers; Body Mass Index; Caffeine; Case-Control Studies; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Logistic Models; Male; Maternal Behavior; Obesity; Pregnancy; Pregnancy Trimester, Second; Prenatal Exposure Delayed Effects; Risk Factors; Theophylline | 2015 |
Urine excretion of caffeine and select caffeine metabolites is common in the U.S. population and associated with caffeine intake.
Topics: Adolescent; Adult; Biomarkers; Black or African American; Caffeine; Child; Chromatography, Liquid; Cross-Sectional Studies; Female; Hispanic or Latino; Humans; Male; Middle Aged; Nutrition Surveys; Tandem Mass Spectrometry; Theophylline; Uracil; Uric Acid; White People; Xanthines; Young Adult | 2015 |
Effects of caffeine and its metabolite paraxanthine on intracranial self-stimulation in male rats.
Topics: Animals; Caffeine; Conditioning, Operant; Male; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Self Stimulation; Theophylline | 2015 |
Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping.
Topics: Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Linear Models; Phenotype; Reproducibility of Results; Saliva; Sensitivity and Specificity; Theophylline | 2015 |
Does volumetric absorptive microsampling eliminate the hematocrit bias for caffeine and paraxanthine in dried blood samples? A comparative study.
Topics: Blood Specimen Collection; Caffeine; Chromatography, Gas; Dried Blood Spot Testing; Healthy Volunteers; Hematocrit; Humans; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Theophylline | 2015 |
Polymorphisms of CYP1A2 and CYP2A6 activity: phenotypes and the effect of age and sex in a Nigerian population.
Topics: Adolescent; Adult; Age Factors; Algorithms; Biomarkers; Biotransformation; Caffeine; Coffee; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Food, Preserved; Humans; Male; Nigeria; Sex Characteristics; Theophylline; Uric Acid; Young Adult | 2015 |
Simultaneous multiplexed quantification of caffeine and its major metabolites theobromine and paraxanthine using surface-enhanced Raman scattering.
Topics: Caffeine; Humans; Limit of Detection; Machine Learning; Neural Networks, Computer; Spectrum Analysis, Raman; Surface Properties; Theobromine; Theophylline | 2015 |
Second-Trimester Maternal Serum Paraxanthine, CYP1A2 Activity, and the Risk of Severe Preeclampsia.
Topics: Adult; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Female; Humans; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Second; Risk Assessment; Theophylline; Young Adult | 2015 |
An optimized and validated SPE-LC-MS/MS method for the determination of caffeine and paraxanthine in hair.
Topics: Adult; Analytic Sample Preparation Methods; Caffeine; Chromatography, Liquid; Female; Hair; Humans; Male; Solid Phase Extraction; Tandem Mass Spectrometry; Theophylline; Young Adult | 2015 |
Maternal Caffeine Intake During Pregnancy and Child Cognition and Behavior at 4 and 7 Years of Age.
Topics: Adult; Caffeine; Child; Child Behavior; Child, Preschool; Coffee; Cognition; Female; Follow-Up Studies; Humans; Pregnancy; Prenatal Exposure Delayed Effects; Retrospective Studies; Risk Factors; Theophylline; Young Adult | 2015 |
Stepwise injection potentiometric determination of caffeine in saliva using single-drop microextraction combined with solvent exchange.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Liquid Phase Microextraction; Potentiometry; Saliva; Theobromine; Theophylline | 2016 |
Serum caffeine and paraxanthine concentrations and menstrual cycle function: correlations with beverage intakes and associations with race, reproductive hormones, and anovulation in the BioCycle Study.
Topics: Adult; Asian People; Caffeine; Coffee; Female; Humans; Menstrual Cycle; Ovulation; Ovulation Inhibition; Racial Groups; Risk Factors; Testosterone; Theophylline; Young Adult | 2016 |
Determination of illicit drugs in aqueous environmental samples by online solid-phase extraction coupled to liquid chromatography-tandem mass spectrometry.
Topics: Caffeine; China; Chromatography, Liquid; Cotinine; Environmental Monitoring; Illicit Drugs; Pseudoephedrine; Reproducibility of Results; Rivers; Solid Phase Extraction; Tandem Mass Spectrometry; Theophylline; Wastewater; Water Pollutants, Chemical | 2016 |
Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior.
Topics: Antigens, CD; Basic Helix-Loop-Helix Transcription Factors; Caffeine; CD83 Antigen; Coffee; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Genome-Wide Association Study; Humans; Immunoglobulins; Male; Membrane Glycoproteins; Polymorphism, Single Nucleotide; Receptors, Aryl Hydrocarbon; Theobromine; Theophylline; White People | 2016 |
Caffeine and paraxanthine in aquatic systems: Global exposure distributions and probabilistic risk assessment.
Topics: Animals; Aquatic Organisms; Caffeine; Chlorophyta; Daphnia; Fishes; Humans; Risk Assessment; Theophylline; Water Movements; Water Pollutants, Chemical | 2018 |
Evaluation of the Capitainer-B Microfluidic Device as a New Hematocrit-Independent Alternative for Dried Blood Spot Collection.
Topics: Caffeine; Calibration; Chromatography, Liquid; Dried Blood Spot Testing; Female; Hematocrit; Humans; Lab-On-A-Chip Devices; Microfluidic Analytical Techniques; Tandem Mass Spectrometry; Theophylline | 2018 |
Prediction of self-assembly of adenosine analogues in solution: a computational approach validated by isothermal titration calorimetry.
Topics: Adenosine; Caffeine; Calorimetry; Dimerization; Models, Molecular; Molecular Structure; Solvents; Structure-Activity Relationship; Surface Properties; Theophylline; Thermodynamics; Water | 2019 |
A Metabolomic Study of Biomarkers of Habitual Coffee Intake in Four European Countries.
Topics: Adult; Aged; Alkaloids; Biomarkers; Caffeine; Coffee; Europe; Female; Humans; Male; Metabolomics; Middle Aged; Prospective Studies; Theophylline | 2019 |
Evaluation of the Performance and Hematocrit Independence of the HemaPEN as a Volumetric Dried Blood Spot Collection Device.
Topics: Caffeine; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Female; Humans; Tandem Mass Spectrometry; Theophylline | 2019 |
In vivo solid-phase microextraction swab sampling of environmental pollutants and drugs in human body for nano-electrospray ionization mass spectrometry analysis.
Topics: Caffeine; Environmental Pollutants; Human Body; Humans; Imidazoles; Mouth; Nanotechnology; Nicotine; Skin; Solid Phase Microextraction; Spectrometry, Mass, Electrospray Ionization; Theobromine; Theophylline | 2020 |
Exploring the Association between Urine Caffeine Metabolites and Urine Flow Rate: A Cross-Sectional Study.
Topics: Adult; Aged; Caffeine; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Nutrition Surveys; Theobromine; Theophylline; Urination | 2020 |
Association Between Maternal Caffeine Consumption and Metabolism and Neonatal Anthropometry: A Secondary Analysis of the NICHD Fetal Growth Studies-Singletons.
Topics: Adult; Anthropometry; Biomarkers; Birth Weight; Caffeine; Female; Fetal Development; Follow-Up Studies; Gestational Age; Humans; Infant, Newborn; Male; Maternal Exposure; Pregnancy; Retrospective Studies; Theophylline | 2021 |
New framework for a non-animal approach adequately assures the safety of cosmetic ingredients - A case study on caffeine.
Topics: Animals; Caffeine; Cosmetics; Eating; Humans; Risk Assessment; Theobromine; Theophylline; Toxicity Tests; Xanthines | 2021 |
The determination of the Paraxanthine/Caffeine ratio as a metabolic biomarker for CYP1A2 activity in various human matrices by UHPLC-ESIMS/MS.
Topics: Biomarkers; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Theophylline | 2021 |
Investigating the Relations Between Caffeine-Derived Metabolites and Plasma Lipids in 2 Population-Based Studies.
Topics: Adult; Belgium; Caffeine; Cholesterol; Cholesterol, HDL; Chromatography, High Pressure Liquid; Female; Humans; Lipids; Male; Middle Aged; Switzerland; Tandem Mass Spectrometry; Theobromine; Theophylline; Triglycerides; Xanthines | 2021 |
Simultaneous determination of caffeine and its metabolites in rat plasma by UHPLC-MS/MS.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Male; Rats; Rats, Wistar; Tandem Mass Spectrometry; Theobromine; Theophylline; Uric Acid | 2021 |
Finger sweat analysis enables short interval metabolic biomonitoring in humans.
Topics: Adult; Biological Monitoring; Biotransformation; Caffeine; Chlorogenic Acid; Chromatography, Liquid; Coffee; Female; Fingers; Humans; Male; Metabolomics; Middle Aged; Principal Component Analysis; Sweat; Tandem Mass Spectrometry; Theobromine; Theophylline | 2021 |
Maternal caffeine intake and DNA methylation in newborn cord blood.
Topics: Adult; Caffeine; DNA Methylation; Epigenesis, Genetic; Female; Fetal Blood; Gestational Age; Humans; Infant, Newborn; Male; Maternal Exposure; Middle Aged; Pregnancy; Theobromine; Theophylline | 2022 |
Caffeine and Paraxanthine as Tracers of Anthropogenic Wastewater in Coastal Lagoons in Yucatan, Mexico.
Topics: Caffeine; Environmental Monitoring; Groundwater; Mexico; Theophylline; Wastewater; Water Pollutants, Chemical | 2022 |
Evaluation of CYP1A2 activity: Relationship between the endogenous urinary 6-hydroxymelatonin to melatonin ratio and paraxanthine to caffeine ratio in dried blood spots.
Topics: Caffeine; Cytochrome P-450 CYP1A2; Dried Blood Spot Testing; Humans; Melatonin; Theophylline | 2022 |
Caffeine, Paraxanthine, Theophylline, and Theobromine Content in Human Milk.
Topics: Caffeine; Chromatography, Liquid; Female; Humans; Milk, Human; Tandem Mass Spectrometry; Theobromine; Theophylline | 2022 |
A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis.
Topics: Animals; Caffeine; Cysteine; Glutathione; HEK293 Cells; Humans; Hydrogen Peroxide; Mice; Neuroblastoma; Theophylline; Uric Acid | 2023 |