Compounds > 1-7-bis(4-hydroxyphenyl)-1-4-6-heptatrien-3-one

1-7-bis(4-hydroxyphenyl)-1-4-6-heptatrien-3-one and procurcumenol

1-7-bis(4-hydroxyphenyl)-1-4-6-heptatrien-3-one has been researched along with procurcumenol* in 1 studies

Other Studies

1 other study(ies) available for 1-7-bis(4-hydroxyphenyl)-1-4-6-heptatrien-3-one and procurcumenol

Article	Year
A curcuminoid and sesquiterpenes as inhibitors of macrophage TNF-alpha release from Curcuma zedoaria. Planta medica, 2001, Volume: 67, Issue:6 Tumor necrosis factor-alpha (TNF-alpha) is one of the major mediators produced in activated macrophages which contribute to the circulatory failure associated with septic shock. In the course of screening marketed oriental anti-inflammatory herbal drugs for TNF-alpha antagonistic activity, a crude methanolic extract of the rhizomes of Curcuma zedoaria exhibited significant activity. The activity-guided fractionation and repetitive chromatographic procedures with the EtOAc-soluble fraction resulted in the isolation of three active compounds. They were identified as 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (1), procurcumenol (2) and epiprocurcumenol (3) by spectral data analysis. They inhibited the production of TNF-alpha by lipopolysaccharide (LPS)-activated macrophages from the results of bioassay (IC(50) values of 1 and 2 are 12.3 and 310.5 microM, respectively) and Western blot assay. These results imply that the traditional use of C. zedoaria rhizome as anti-inflammatory drug may be explained at least in part, by the inhibition of TNF-alpha production. Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Assay; Blotting, Western; Cell Line; Cell Survival; Curcumin; Inhibitory Concentration 50; Macrophages; Magnetic Resonance Spectroscopy; Phenols; Plant Extracts; Plant Structures; Plants, Medicinal; Sesquiterpenes; Tumor Necrosis Factor-alpha; Zingiberaceae	2001

Article

Year

A curcuminoid and sesquiterpenes as inhibitors of macrophage TNF-alpha release from Curcuma zedoaria.

Planta medica, 2001, Volume: 67, Issue:6

Tumor necrosis factor-alpha (TNF-alpha) is one of the major mediators produced in activated macrophages which contribute to the circulatory failure associated with septic shock. In the course of screening marketed oriental anti-inflammatory herbal drugs for TNF-alpha antagonistic activity, a crude methanolic extract of the rhizomes of Curcuma zedoaria exhibited significant activity. The activity-guided fractionation and repetitive chromatographic procedures with the EtOAc-soluble fraction resulted in the isolation of three active compounds. They were identified as 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (1), procurcumenol (2) and epiprocurcumenol (3) by spectral data analysis. They inhibited the production of TNF-alpha by lipopolysaccharide (LPS)-activated macrophages from the results of bioassay (IC(50) values of 1 and 2 are 12.3 and 310.5 microM, respectively) and Western blot assay. These results imply that the traditional use of C. zedoaria rhizome as anti-inflammatory drug may be explained at least in part, by the inhibition of TNF-alpha production.

Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Assay; Blotting, Western; Cell Line; Cell Survival; Curcumin; Inhibitory Concentration 50; Macrophages; Magnetic Resonance Spectroscopy; Phenols; Plant Extracts; Plant Structures; Plants, Medicinal; Sesquiterpenes; Tumor Necrosis Factor-alpha; Zingiberaceae

2001