1-6-dihydroxyxanthone and piperidine

1-6-dihydroxyxanthone has been researched along with piperidine* in 1 studies

Other Studies

1 other study(ies) available for 1-6-dihydroxyxanthone and piperidine

Article	Year
Antitumor activity and DNA-binding investigations of isoeuxanthone and its piperidinyl derivative. Chemical & pharmaceutical bulletin, 2013, Volume: 61, Issue:6 The binding mode and affinity of isoeuxanthone (1,6-dihydroxyxanthone) (1) and its piperidinyl derivative (1-hydroxy-6-(2-(1-piperidinyl)ethoxy)xanthone) (2) with calf thymus DNA were studied using absorption spectroscopy, fluorescence spectroscopy, circular dichroism (CD) spectroscopy and viscosity measurements. Results indicate that the two xanthones can intercalate into the DNA base pairs by the plane of xanthone ring and the binding affinity of the piperidinylethoxy substituted xanthone 2 is stronger than 1. In addition, the cytotoxic effects of both compounds were evaluated with the human cervical cancer cell line (HeLa) and human hepatocellular liver carcinoma cell line (HepG2) using acid phosphatase assay. Analyses show that the piperidinylethoxy substituted xanthone exhibits more effective cytotoxic activity than isoeuxanthone against the two cancer cells. The effects on the inhibition of tumor cells in vitro agree with the studies of DNA-binding. Topics: Animals; Antineoplastic Agents; Cattle; Cell Survival; Circular Dichroism; DNA; HeLa Cells; Hep G2 Cells; Humans; Piperidines; Spectrophotometry, Ultraviolet; Xanthones	2013

Article

Year

Antitumor activity and DNA-binding investigations of isoeuxanthone and its piperidinyl derivative.

Chemical & pharmaceutical bulletin, 2013, Volume: 61, Issue:6

The binding mode and affinity of isoeuxanthone (1,6-dihydroxyxanthone) (1) and its piperidinyl derivative (1-hydroxy-6-(2-(1-piperidinyl)ethoxy)xanthone) (2) with calf thymus DNA were studied using absorption spectroscopy, fluorescence spectroscopy, circular dichroism (CD) spectroscopy and viscosity measurements. Results indicate that the two xanthones can intercalate into the DNA base pairs by the plane of xanthone ring and the binding affinity of the piperidinylethoxy substituted xanthone 2 is stronger than 1. In addition, the cytotoxic effects of both compounds were evaluated with the human cervical cancer cell line (HeLa) and human hepatocellular liver carcinoma cell line (HepG2) using acid phosphatase assay. Analyses show that the piperidinylethoxy substituted xanthone exhibits more effective cytotoxic activity than isoeuxanthone against the two cancer cells. The effects on the inhibition of tumor cells in vitro agree with the studies of DNA-binding.

Topics: Animals; Antineoplastic Agents; Cattle; Cell Survival; Circular Dichroism; DNA; HeLa Cells; Hep G2 Cells; Humans; Piperidines; Spectrophotometry, Ultraviolet; Xanthones

2013