1,6-bis(cyclohexyloximinocarbonyl)hexane has been researched along with tiletamine hydrochloride in 135 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (25.19) | 18.7374 |
| 1990's | 57 (42.22) | 18.2507 |
| 2000's | 32 (23.70) | 29.6817 |
| 2010's | 12 (8.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harrison, RA; Roldan, ER | 1 |
| Jolly, YC; Konrad, RJ; Major, C; Wolf, BA | 1 |
| Carroll, R; Severson, DL | 1 |
| Balsinde, J; Diez, E; Fernández, B; Solís-Herruzo, JA | 1 |
| Foreman, JC; Hayes, NA; McLeod, J | 1 |
| Hsu, YL; Kondratenko, NF; Pandol, SJ; Schoeffield-Payne, MS; Steinbach, JH | 1 |
| Allen, AC; Gammon, CM; McCarthy, KD; Morell, P; Ousley, AH | 1 |
| de Nucci, G; Mitchell, JA; Vane, JR; Warner, TD | 1 |
| Cybulsky, AV | 1 |
| Chuang, M; Hollenberg, MD; Saifeddine, M; Severson, DL; Yang, SG | 1 |
| Boarder, MR; Jones, JA; Owen, PJ | 1 |
| Bismuth, G; Colard, O; Debre, P; Le Gouvello, S; Tarantino, N; Theodorou, I | 1 |
| Bockman, RS; Rapuano, BE | 2 |
| Galatioto, LE; Rindlisbacher, B; Sidler, MA; Zahler, P | 1 |
| Burgoyne, RD; Morgan, A | 1 |
| Dickinson, KE; Hirschowitz, BI; Hokin, LE; Pruitt, RE; Sekar, MC | 1 |
| Chuang, M; Severson, DL | 1 |
| Dunn, WD; Nadler, J; Natarajan, R; Stern, N | 1 |
| Gao, G; Serrero, G | 1 |
| Judd, AM; Koike, K; MacLeod, RM | 1 |
| Hokin, LE; Sekar, MC | 1 |
| Cantwell, ME; Foreman, JC | 1 |
| Abumrad, NA; Barnela, US; Harmon, CM; Whitesell, RR | 1 |
| Kolb, HA; Somogyi, R | 1 |
| Kopp, R; Pfeiffer, A; Rochlitz, H | 1 |
| Burch, RM | 1 |
| Bicknell, R; Vallee, BL | 1 |
| Capito, K; Hansen, SE; Hedeskov, CJ; Thams, P | 1 |
| Dale, MM; Penfield, A | 1 |
| Dale, MM; Muid, RE; Twomey, B | 1 |
| Nadler, J; Natarajan, R; Stern, N | 1 |
| Levine, SD; Schlondorff, D | 1 |
| Bell, RM; Bishop, WR | 1 |
| Dale, MM; Muid, RE; Penfield, A | 1 |
| Amin, D; Jamall, IS; Kapoor, AL; Khandwala, AS; Sutherland, CA | 1 |
| Cooper, CL; Malik, KU | 1 |
| DeCandido, S; Satriano, JA; Schlondorff, D | 1 |
| Schimmel, RJ | 1 |
| Catt, KJ; Chang, JP; Morgan, RO | 1 |
| Ekman, P; Nilsson, E | 1 |
| Reist, M; Rindlisbacher, B; Zahler, P | 1 |
| Cabot, MC; Zhang, ZC | 1 |
| Camoratto, AM; Grandison, L | 1 |
| Abdel-Latif, AA; Yousufzai, SY | 1 |
| Canonico, PL; Cronin, MJ; MacLeod, RM | 1 |
| Canonico, PL; Scapagnini, U; Sortino, MA; Speciale, C | 1 |
| Chau, LY; Tai, HH | 1 |
| Bross, TE; Majerus, PW; Prescott, SM | 1 |
| Gorman, RR; Oglesby, TD | 1 |
| Burke, G; Kostelec, M; Levasseur, S | 1 |
| Dixon, JF; Hokin, LE | 1 |
| Franson, RC; Rosenblum, WI | 1 |
| Amin, D; Sutherland, CA | 1 |
| Clotz, MA; Haun, SE; Horrocks, LA; Trapp, VL | 1 |
| Barrett, KE | 1 |
| Ambs, P; Dieter, P; Fitzke, E | 1 |
| Konrad, RJ; Major, CD; Wolf, BA | 1 |
| Doherty, P; Furness, J; Walsh, FS; Williams, EJ | 1 |
| Acamovic, F; Mackie, SC; Morrison, KS; Palmer, RM; Thompson, MG | 1 |
| Chuang, M; Lee, MW; Severson, DL; Zhao, D | 1 |
| Mitchell, R; Thomson, FJ | 1 |
| Dieter, P; Fitzke, E | 1 |
| Cisar, LA; Mochan, E; Schimmel, R | 1 |
| Delfino, JM; Florin-Christensen, J; Florin-Christensen, M; Rasmussen, H | 1 |
| Hollenberg, MD; Laniyonu, A; Saifeddine, M; Yang, SG | 1 |
| Ball, SG; Murphy, MG; Vaughan, PF | 1 |
| Leonardi, P; Lombardi, G; Moroni, F | 1 |
| Burt, RP; Chapple, CR; Marshall, I | 1 |
| Akiba, S; Ishimoto, T; Sato, T | 1 |
| Brittis, PA; Doherty, P; Silver, J; Walsh, FS | 1 |
| Capito, K; Hansen, SE; Thams, P | 1 |
| Arita, Y; Hou, W; Morisset, J | 2 |
| Hollenberg, MD; Zheng, XL | 1 |
| Helliwell, RM; Large, WA | 1 |
| Pagano, RE; Salman, M | 1 |
| Kozawa, O; Oiso, Y; Shinoda, J; Suzuki, A; Uematsu, T; Watanabe-Tomita, Y | 1 |
| Capito, K; Thams, P | 1 |
| Hollenberg, MD; Mokashi, S; Zheng, XL | 1 |
| Kozawa, O; Oiso, Y; Saito, H; Shinoda, J; Suzuki, A; Watanabe-Tomita, Y | 1 |
| Kozawa, O; Oiso, Y; Shinoda, J; Suzuki, A; Watanabe-Tomita, Y | 1 |
| Hébert, RL; Kennedy, CR; Lal, MA; Proulx, PR | 1 |
| Doherty, P; Meiri, KF; Saffell, JL; Walsh, FS | 1 |
| Bixby, JL; Holt, CE; Höpker, V; Lom, B; McFarlane, S | 1 |
| Liu, L | 1 |
| Bisogno, T; De Petrocellis, L; Di Marzo, V; Melck, D | 1 |
| Honeyman, TW; Kennington, L; Kohjimoto, Y; Scheid, CR | 1 |
| Johnson, KR; Nieman, MT; Prudoff, RS; Wheelock, MJ | 1 |
| Archer, FR; Bolsover, SR; Collins, D; Doherty, P | 1 |
| Chakrabarti, R; Kumar, S | 2 |
| Freeman, EJ | 1 |
| LaBelle, EF; Polyak, E | 1 |
| Cocks, TM; Drummond, GR; Selemidis, S | 1 |
| Eker, P; Garred, O; Llorente, A; Sandvig, K; van Deurs, B | 1 |
| Ascher-Landsberg, J; Phillippe, M; Saunders, T | 1 |
| Malik, KU; Muthalif, MM; Nishimoto, AT; Parmentier, JH | 1 |
| Coats, P; Hillier, C; Johnston, F; MacDonald, J; McMurray, JJ | 1 |
| Choi, MU; Lee, SJ; Lee, SY; Park, HS | 1 |
| Bates, DO; Pocock, TM | 1 |
| Bomser, JA; Casida, JE; Quistad, GB | 1 |
| Bova, S; Cargnelli, G; Ceolotto, G; Luciani, S; Trevisi, L | 1 |
| Asbun, J; Castillo, C; Castillo, EF; Escalante, B | 1 |
| Gscheidlinger, R; Hohenegger, M; Karel, A; Weigl, L; Zidar, A | 1 |
| Fukuta, H; Kito, Y; Suzuki, H; Yamamoto, Y | 1 |
| Anderson, R; Bopape, MC; Cockeran, R; Fourie, PB; Matlola, NM; Steel, HC | 1 |
| Okada, S; Shimizu, T; Yamaguchi-Shima, N; Yokotani, K | 1 |
| Cloutier, M; Morin, C; Proteau, S; Rousseau, E | 1 |
| Campbell, WB; Endsley, MP; Falck, JR; Hillard, CJ; Isbell, MA; Iwamoto, Y; Nithipatikom, K | 1 |
| Arai, J; Okada, S; Shimizu, T; Wakiguchi, H; Yamaguchi, N; Yokotani, K | 1 |
| Ghisdal, P; Hamaide, MC; Morel, N; Vandenberg, G; Wibo, M | 1 |
| Campbell, WB; Edwards, EM; Falck, JR; Holmes, BB; Tang, X | 1 |
| Alava, MA; Anel, A; Barrio, G; Iturralde, M; Lacasa, E; Naval, J; Pardo, J; Piñeiro, A | 1 |
| Applegate, MA; Estacion, M; Jones, SW; Schilling, WP; Sinkins, WG | 1 |
| Guibert, C; Marthan, R; Rodat, L; Savineau, JP | 1 |
| Lu, L; Okada, S; Sasaki, T; Shimizu, T; Yamaguchi, N; Yokotani, K | 1 |
| Shimizu, T; Yokotani, K | 1 |
| Egertová, M; Heneghan, JF; Liu, L; Michael, GJ; Rittenhouse, AR; Stanish, LF | 1 |
| Blankman, JL; Cravatt, BF; Hoover, HS; Niessen, S | 1 |
| Bouron, A; Brinkmeier, H; Kunert-Keil, C; Lucke, S; Tu, P | 1 |
| Rubio, ME; Tzounopoulos, T; Zhao, Y | 1 |
| Gaveglio, VL; Giusto, NM; Pasquaré, SJ | 1 |
| Bisogno, T; Brussaard, AB; Burnashev, N; Canto, CB; Di Marzo, V; Heistek, TS; Lodder, JC; Mansvelder, HD; Min, R; Testa-Silva, G | 1 |
| Burrell, BD; Yuan, S | 1 |
| Ferrero, JJ; Sánchez-Prieto, J; Torres, M | 1 |
| Blat, Y; Fanslau, C; Flynn, MJ; Hunihan, L; Miranda, M; Pearce, BC; Pedicord, DL; Robertson, BJ; Westphal, RS; Yu, XC | 1 |
| Cui, Y; Georges, F; Grandes, P; Lafourcade, M; Lassalle, O; Manzoni, OJ; Puente, N; Venance, L | 1 |
| Gregg, LC; Hohmann, AG; Jung, KM; Katona, I; Mackie, K; Nyilas, R; Piomelli, D; Spradley, JM; Suplita, RL; Watanabe, M; Zimmer, A | 1 |
| Nakamura, K; Shimizu, T; Tanaka, K; Taniuchi, K; Yokotani, K | 1 |
| Jiang, W; Ma, H; Ma, L; Meng, XD; Wang, L; Wu, C; Yang, F | 1 |
| Chen, B; Chen, Z; Dai, Y; Feng, B; Hu, W; Shi, L; Tang, Y; Wang, S; Wang, Y; Wu, D; Xu, C; Zhang, X; Zhou, Y; Zhu, J | 1 |
| Bhowmick, R; Bonventre, JV; Clark, S; Leong, JM; McCormick, BA | 1 |
| Fichna, J; Krajewska, U; Lewandowska, U; Owczarek, K; Wasilewski, A | 1 |
| Fichna, J; Misicka, A; Sacharczuk, M; Wasilewski, A | 1 |
135 other study(ies) available for 1,6-bis(cyclohexyloximinocarbonyl)hexane and tiletamine hydrochloride
| Article | Year |
|---|---|
The role of diacylglycerol in the exocytosis of the sperm acrosome. Studies using diacylglycerol lipase and diacylglycerol kinase inhibitors and exogenous diacylglycerols.
Topics: Acrosome; Animals; Calcimycin; Calcium; Cyclohexanones; Diacylglycerol Kinase; Diglycerides; Exocytosis; Lipoprotein Lipase; Male; Neomycin; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphotransferases; Pyrimidinones; Sheep; Spermatozoa; Thiazoles | 1992 |
Carbachol stimulation of phospholipase A2 and insulin secretion in pancreatic islets.
Topics: Animals; Arachidonic Acid; Calcium; Carbachol; Cyclohexanones; Diglycerides; Enzyme Activation; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Lipoprotein Lipase; Lysophosphatidylcholines; Male; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Signal Transduction | 1992 |
Inhibition of myocardial lipoprotein lipase by U-57,908 (RHC 80267).
Topics: Animals; Cyclohexanones; In Vitro Techniques; Lipoprotein Lipase; Male; Myocardium; Rats; Rats, Inbred Strains; Triolein; Tritium | 1992 |
Pathways for arachidonic acid mobilization in zymosan-stimulated mouse peritoneal macrophages.
Topics: Acyltransferases; Animals; Arachidonic Acid; Cells, Cultured; Cyclohexanones; Dose-Response Relationship, Drug; Enzyme Activation; Lipoprotein Lipase; Macrophage Activation; Macrophages; Masoprocol; Mice; Peritoneum; Phospholipases A; Phospholipases A2; Serum Albumin, Bovine; Zymosan | 1992 |
Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on substance P-induced histamine release from rat peritoneal mast cells.
Topics: Animals; Ascitic Fluid; Calcium; Cyclohexanones; Female; Histamine Release; In Vitro Techniques; Male; Mast Cells; Platelet Activating Factor; Pyrimidinones; Rats; Rats, Inbred Strains; Substance P; Tetradecanoylphorbol Acetate; Thiazoles | 1990 |
Dual pathways for agonist-stimulated arachidonic acid release in pancreatic acini: roles in secretion.
Topics: Amylases; Animals; Arachidonic Acids; Cyclohexanones; Diglycerides; Fatty Acids; Guinea Pigs; In Vitro Techniques; Kinetics; Lipoprotein Lipase; Lysophosphatidylcholines; Pancreas; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Sincalide; Tetradecanoylphorbol Acetate | 1991 |
Bradykinin stimulates arachidonic acid release through the sequential actions of an sn-1 diacylglycerol lipase and a monoacylglycerol lipase.
Topics: Animals; Arachidonic Acid; Bradykinin; Cyclohexanones; Diglycerides; Fatty Acids; Lipoprotein Lipase; Lysophospholipids; Monoacylglycerol Lipases; Neurons; Phospholipids; Rats; Rats, Inbred Strains | 1992 |
Alkaline buffers release EDRF from bovine cultured aortic endothelial cells.
Topics: Animals; Arginine; Buffers; Cattle; Cells, Cultured; Cyclohexanones; Endothelium, Vascular; Epoprostenol; Hydrogen-Ion Concentration; Lipoprotein Lipase; Nitric Oxide; omega-N-Methylarginine; Platelet Activating Factor; Pyrimidinones; Thiazoles | 1991 |
Release of arachidonic acid by complement C5b-9 complex in glomerular epithelial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cells, Cultured; Complement Membrane Attack Complex; Cyclohexanones; Diglycerides; Edetic Acid; Egtazic Acid; Epithelium; Fatty Acids, Nonesterified; Kidney Glomerulus; Kinetics; Lipase; Lipoprotein Lipase; Phospholipases A; Phospholipases A2; Phospholipids; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1991 |
Diacylglycerol lipase and the contractile action of epidermal growth factor-urogastrone: evidence for distinct signal pathways in a single strip of gastric smooth muscle.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Cyclohexanones; Dinoprost; Epidermal Growth Factor; Guinea Pigs; Immunoenzyme Techniques; Lipoprotein Lipase; Muscle Contraction; Muscle, Smooth; Phospholipases A; Phospholipases A2; Signal Transduction; Transforming Growth Factor alpha | 1991 |
Influence of phorbol esters, and diacylglycerol kinase and lipase inhibitors on noradrenaline release and phosphoinositide hydrolysis in chromaffin cells.
Topics: Adrenal Medulla; Animals; Cattle; Cyclohexanones; Diacylglycerol Kinase; Hydrolysis; In Vitro Techniques; Lipoprotein Lipase; Norepinephrine; Phosphatidylinositols; Phosphotransferases; Pyrimidinones; Tetradecanoylphorbol Acetate; Thiazoles | 1990 |
CD2 triggering stimulates a phospholipase A2 activity beside the phospholipase C pathway in human T lymphocytes.
Topics: Antigens, Differentiation, T-Lymphocyte; Arachidonic Acid; Arachidonic Acids; Calcium; CD2 Antigens; CD4-Positive T-Lymphocytes; Clone Cells; Cyclic AMP; Cyclohexanones; Enzyme Activation; Humans; In Vitro Techniques; Lipoprotein Lipase; Lymphocyte Activation; Phospholipases; Phospholipases A; Phospholipases A2; Protein Kinase C; Receptors, Immunologic; Signal Transduction; Type C Phospholipases | 1990 |
Tumor necrosis factor-alpha stimulates phosphatidylinositol breakdown by phospholipase C to coordinately increase the levels of diacylglycerol, free arachidonic acid and prostaglandins in an osteoblast (MC3T3-E1) cell line.
Topics: Animals; Arachidonic Acids; Cell Line; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cyclohexanones; Diglycerides; Kinetics; Lipoprotein Lipase; Mice; Osteoblasts; Phosphates; Phosphatidylinositols; Phospholipids; Prostaglandins; Recombinant Proteins; Tumor Necrosis Factor-alpha; Type C Phospholipases | 1991 |
Arachidonic acid liberated by diacylglycerol lipase is essential for the release mechanism in chromaffin cells from bovine adrenal medulla.
Topics: Acetylcholine; Adrenal Medulla; Animals; Arachidonic Acid; Arachidonic Acids; Biomechanical Phenomena; Catecholamines; Cattle; Cell Separation; Cell Survival; Chromaffin System; Cyclohexanones; Lipoprotein Lipase; Lipoxygenase Inhibitors; Osmolar Concentration | 1990 |
Relationship between arachidonic acid release and Ca2(+)-dependent exocytosis in digitonin-permeabilized bovine adrenal chromaffin cells.
Topics: Adrenal Glands; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cattle; Cell Membrane Permeability; Chromaffin Granules; Cyclohexanones; Digitonin; Ethylmaleimide; Exocytosis; Indomethacin; Phospholipases A; Phospholipases A2; Protein Kinase C; Quinacrine; Staurosporine | 1990 |
Muscarinic receptor antagonist activity of diacylglycerol lipase and kinase inhibitors.
Topics: Animals; Brain; Cells, Cultured; Cyclic GMP; Cyclohexanes; Cyclohexanones; Guinea Pigs; Heart; Lipoprotein Lipase; Myocardium; N-Methylscopolamine; Pancreas; Parasympatholytics; Platelet Activating Factor; Pyrimidinones; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Thiazoles; Tritium | 1990 |
Inhibition of diacylglycerol metabolism in isolated cardiac myocytes by U-57 908 (RHC 80267), a diacylglycerol lipase inhibitor.
Topics: Animals; Cyclohexanones; Diacylglycerol Kinase; Diglycerides; Heart; In Vitro Techniques; Kinetics; Lipoprotein Lipase; Male; Myocardium; Phosphotransferases; Rats; Rats, Inbred Strains; Triglycerides | 1990 |
Key role of diacylglycerol-mediated 12-lipoxygenase product formation in angiotensin II-induced aldosterone synthesis.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Aldosterone; Angiotensin II; Animals; Arachidonate 12-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Cyclohexanones; Diacylglycerol Kinase; Diglycerides; Hydroxyeicosatetraenoic Acids; Lipoprotein Lipase; Male; Phosphotransferases; Pyrimidinones; Rats; Rats, Inbred Strains; Thiazoles; Zona Glomerulosa | 1990 |
Phospholipase A2 is a differentiation-dependent enzymatic activity for adipogenic cell line and adipocyte precursors in primary culture.
Topics: Adipose Tissue; Aminobenzoates; Animals; Arachidonic Acids; Cell Differentiation; Cell Line; Chlorobenzoates; Cinnamates; Cyclohexanones; Glyceraldehyde-3-Phosphate Dehydrogenases; Kinetics; ortho-Aminobenzoates; Phospholipases; Phospholipases A; Phospholipases A2; Prostaglandins; Quinacrine; Radioimmunoassay; Teratoma; Thromboxane B2 | 1990 |
A possible role of arachidonate metabolism in the mechanism of prolactin release.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cells, Cultured; Cobalt; Cyclohexanones; Dopamine; Female; Ion Channels; Marine Toxins; Neurotensin; Oxocins; Penfluridol; Phospholipids; Pituitary Gland, Anterior; Prolactin; Pyrazoles; Rats; Rats, Inbred Strains; Somatostatin; Stimulation, Chemical; Thyrotropin-Releasing Hormone | 1986 |
Inhibitors of diacylglycerol lipase and diacylglycerol kinase inhibit carbamylcholine-stimulated responses in guinea pig pancreatic minilobules.
Topics: Amylases; Animals; Carbachol; Cyclic GMP; Cyclohexanes; Cyclohexanones; Diacylglycerol Kinase; Ethers; Guinea Pigs; Inositol Phosphates; Ionomycin; Kinetics; Lipoprotein Lipase; Nitroprusside; Pancreas; Phosphotransferases; Sugar Phosphates | 1987 |
The actions of inhibitors of diacylglycerol kinase and diacylglycerol lipase on histamine release from rat peritoneal mast cells.
Topics: Animals; Cyclohexanones; Diacylglycerol Kinase; Histamine Release; In Vitro Techniques; Lipoprotein Lipase; Male; Mast Cells; Peritoneal Cavity; Phosphotransferases; Pyrimidinones; Rats; Rats, Inbred Strains; Thiazoles | 1987 |
Insulin antagonism of catecholamine stimulation of fatty acid transport in the adipocyte. Studies on its mechanism of action.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Biological Transport; Cell Membrane; Cells, Cultured; Cyclic AMP; Cyclohexanones; Epinephrine; Insulin; Kinetics; Lipolysis; Lipoprotein Lipase; Norepinephrine; Oleic Acid; Oleic Acids; Protein Kinases; Rats; Rats, Inbred Strains; Reference Values | 1988 |
A G-protein mediates secretagogue-induced gap junctional channel closure in pancreatic acinar cells.
Topics: Animals; Carbachol; Cyclohexanones; Electric Conductivity; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Intercellular Junctions; Ion Channels; Kinetics; Lipase; Male; Mice; Mice, Inbred Strains; Pancreas; Thionucleotides | 1989 |
Stimulation of inositol phosphate and diacylglycerol production by RHC 80267, a diacylglycerol-lipase inhibitor, in rat gastric parietal cells: effects on hydrogen ion secretion.
Topics: Aminopyrine; Animals; Arachidonic Acid; Arachidonic Acids; Bucladesine; Carbachol; Cyclohexanes; Cyclohexanones; Diglycerides; Gastric Acid; Glycerides; Inositol Phosphates; Parietal Cells, Gastric; Rats; Sugar Phosphates; Type C Phospholipases | 1989 |
Diacylglycerol in the synergy of bradykinin and thrombin stimulation of prostaglandin synthesis.
Topics: Animals; Bradykinin; Cyclohexanones; Diacylglycerol Kinase; Diglycerides; Dinoprostone; Drug Synergism; Fibroblasts; Glycerides; Mice; Mice, Inbred BALB C; Phosphotransferases; Pyrimidinones; Thiazoles; Thrombin; Time Factors | 1989 |
Angiogenin stimulates endothelial cell prostacyclin secretion by activation of phospholipase A2.
Topics: Angiogenesis Inducing Agents; Animals; Arachidonic Acids; Cattle; Cells, Cultured; Cyclohexanones; Dexamethasone; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Growth Substances; Humans; Kinetics; Lipoprotein Lipase; Neoplasm Proteins; Pertussis Toxin; Phospholipases; Phospholipases A; Phospholipases A2; Protein Kinase C; Quinacrine; Ribonuclease, Pancreatic; Virulence Factors, Bordetella | 1989 |
Effect of diacylglycerol lipase inhibitor RHC 80267 on pancreatic mouse islet metabolism and insulin secretion.
Topics: Adenosine Triphosphate; Animals; Cyclohexanes; Cyclohexanones; Glucose; Glycogen; Glycolysis; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Lactates; Lipids; Lipoprotein Lipase; Male; Mice; Type C Phospholipases | 1989 |
Comparison of the effects of indomethacin, RHC80267 and R59022 on superoxide production by 1,oleoyl-2,acetyl glycerol and A23187 in human neutrophils.
Topics: Angiotensin-Converting Enzyme Inhibitors; Calcimycin; Cyclohexanes; Cyclohexanones; Diglycerides; Glycerides; Humans; In Vitro Techniques; Indomethacin; Kinetics; Neutrophils; Platelet Activating Factor; Pyrimidinones; Superoxides; Thiazoles | 1987 |
The effect of inhibition of both diacylglycerol metabolism and phospholipase A2 activity on superoxide generation by human neutrophils.
Topics: Cyclohexanones; Diacylglycerol Kinase; Humans; Indomethacin; Lipoprotein Lipase; Meclofenamic Acid; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Phosphotransferases; Pyrimidinones; Sodium Fluoride; Superoxides; Thiazoles | 1988 |
Diacylglycerol provides arachidonic acid for lipoxygenase products that mediate angiotensin II-induced aldosterone synthesis.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Arachidonate 12-Lipoxygenase; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cyclohexanones; Diglycerides; Glycerides; Humans; Hydroxyeicosatetraenoic Acids; Lipase; Potassium; Second Messenger Systems; Zona Glomerulosa | 1988 |
Inhibition of vasopressin-stimulated water flow in toad bladder by phorbol myristate acetate, dioctanoylglycerol, and RHC-80267. Evidence for modulation of action of vasopressin by protein kinase C.
Topics: Animals; Anura; Biological Transport, Active; Body Water; Cyclic AMP; Cyclohexanes; Cyclohexanones; Diglycerides; Dinoprostone; Epithelium; Female; Glycerides; Lipoprotein Lipase; Mucous Membrane; Phorbols; Prostaglandins E; Protein Kinase C; Serous Membrane; Tetradecanoylphorbol Acetate; Urinary Bladder; Vasopressins | 1985 |
Attenuation of sn-1,2-diacylglycerol second messengers. Metabolism of exogenous diacylglycerols by human platelets.
Topics: Blood Platelets; Cyclohexanones; Diacylglycerol Kinase; Diglycerides; Glycerides; Humans; Lipoprotein Lipase; Phosphotransferases; Thrombin | 1986 |
The diacylglycerol kinase inhibitor, R59022, enhances the superoxide generation from human neutrophils induced by stimulation of fMet-Leu-Phe, IgG and C3b receptors.
Topics: Cyclohexanones; Diacylglycerol Kinase; Diglycerides; Humans; In Vitro Techniques; Lipoprotein Lipase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphotransferases; Protein Kinase C; Pyrimidinones; Receptors, Complement; Receptors, Complement 3b; Receptors, Fc; Receptors, Formyl Peptide; Receptors, Immunologic; Superoxides; Thiazoles | 1987 |
Inhibition of the effects of thrombin on guinea pig platelets by the diacylglycerol lipase inhibitor RHC 80267.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Carbon Radioisotopes; Cyclohexanes; Cyclohexanones; Dose-Response Relationship, Drug; Guinea Pigs; Lipoprotein Lipase; Microsomes; Platelet Aggregation; Thrombin; Type C Phospholipases | 1986 |
Evidence that bradykinin stimulates renal prostaglandin synthesis by a mechanism distinct from that of other vasoactive substances.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Arginine Vasopressin; Bradykinin; Caffeine; Calcium; Cyclohexanones; Isotonic Solutions; Kidney; Male; Muscle, Smooth, Vascular; Norepinephrine; Prostaglandins; Rats | 1987 |
Angiotensin II stimulates phospholipases C and A2 in cultured rat mesangial cells.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cyclohexanones; Diglycerides; Dinoprostone; Glomerular Mesangium; Inositol Phosphates; Lipase; Phospholipases; Phospholipases A; Phospholipases A2; Phospholipids; Prostaglandins E; Rats; Stimulation, Chemical; Trifluoperazine; Type C Phospholipases | 1987 |
The alpha 1-adrenergic transduction system in hamster brown adipocytes. Release of arachidonic acid accompanies activation of phospholipase C.
Topics: Adipose Tissue, Brown; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Colforsin; Cricetinae; Cyclohexanones; Egtazic Acid; Enzyme Activation; In Vitro Techniques; Inositol Phosphates; Insulin; Isoproterenol; Lipid Metabolism; Male; Phenylephrine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1988 |
Dependence of secretory responses to gonadotropin-releasing hormone on diacylglycerol metabolism. Studies with a diacylglycerol lipase inhibitor, RHC 80267.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclohexanes; Cyclohexanones; Diglycerides; Ethers; Female; Follicle Stimulating Hormone; Glycerides; Gonadotropin-Releasing Hormone; Ionomycin; Lipoprotein Lipase; Luteinizing Hormone; Pituitary Gland, Anterior; Rats; Tetradecanoylphorbol Acetate | 1988 |
Phosphorylation of glucokinase from rat liver in vitro by protein kinase A with a concomitant decrease of its activity.
Topics: Animals; Cyclohexanones; Electrophoresis, Polyacrylamide Gel; Glucokinase; Humans; Kinetics; Liver; Magnesium; Muscles; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Rats; Swine | 1988 |
Diacylglycerol breakdown in plasma membranes of bovine chromaffin cells is a two-step mechanism mediated by a diacylglycerol lipase and a monoacylglycerol lipase.
Topics: Acetophenones; Adrenal Medulla; Animals; Calcium; Calmodulin; Carboxylic Ester Hydrolases; Cattle; Cell Membrane; Chlorpromazine; Cyclohexanones; Diglycerides; Glycerides; Hydrogen-Ion Concentration; Lipoprotein Lipase; Monoacylglycerol Lipases | 1987 |
Modification of serum, pancreatic, and microbial lipase activities by phorbol diesters.
Topics: Animals; Cyclohexanones; Diglycerides; Dose-Response Relationship, Drug; Hydrolysis; Lipase; Pancreas; Phorbol Esters; Rats; Rhizopus; Structure-Activity Relationship; Swine; Tetradecanoylphorbol Acetate | 1987 |
Effects of RHC 80267, a diglyceride lipase inhibitor, on prolactin secretion and calcium uptake in GH3 pituitary cells.
Topics: Animals; Calcium; Cells, Cultured; Cyclohexanes; Cyclohexanones; Lipoprotein Lipase; Pituitary Gland, Anterior; Potassium; Prolactin; Rats; Type C Phospholipases | 1987 |
Effects of (1,6-di(O-carbamoyl)cyclohexanone oxime)hexane (RHC 80267) on prostaglandin biosynthesis and accumulation of diacylglycerol and arachidonic acid in rabbit iris.
Topics: Animals; Arachidonic Acids; Cattle; Cyclohexanes; Cyclohexanones; Diglycerides; Dinoprostone; Glycerides; In Vitro Techniques; Iris; Lipoprotein Lipase; Microsomes; Phospholipids; Prostaglandins; Prostaglandins E; Rabbits | 1985 |
Diacylglycerol lipase and pituitary prolactin release in vitro: studies employing RHC 80267.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclohexanones; Dose-Response Relationship, Drug; Female; Lipoprotein Lipase; Male; Pituitary Gland, Anterior; Potassium; Prolactin; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone | 1985 |
Involvement of arachidonate metabolism in neurotensin-induced prolactin release in vitro.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Cyclohexanones; Female; In Vitro Techniques; Kinetics; Lipoprotein Lipase; Neurotensin; Pituitary Gland; Prolactin; Pyrazoles; Quinacrine; Rats; Rats, Inbred Strains; Tritium | 1985 |
Diglyceride/monoglyceride lipases pathway is not essential for arachidonate release in thrombin-activated human platelets.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Carboxylic Ester Hydrolases; Cyclohexanones; Diacylglycerol Kinase; Diglycerides; Glycerides; Humans; Lipoprotein Lipase; Monoacylglycerol Lipases; Phosphotransferases; Thrombin | 1983 |
RHC 80267 does not inhibit the diglyceride lipase pathway in intact platelets.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cyclohexanones; Humans; Lipoprotein Lipase; Microsomes | 1983 |
The inhibition of arachidonic acid metabolism in human platelets by RHC 80267, a diacylglycerol lipase inhibitor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cyclohexanes; Cyclohexanones; Cyclooxygenase Inhibitors; Humans; Lipoprotein Lipase; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Thromboxane B2; Type C Phospholipases | 1984 |
RHC 80267 inhibits thyrotropin-stimulated prostaglandin release from rat thyroid lobes.
Topics: Animals; Cyclohexanes; Cyclohexanones; Diglycerides; Lipoprotein Lipase; Male; Phosphatidylinositols; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Thyroid Gland; Thyrotropin; Type C Phospholipases | 1984 |
Secretogogue-stimulated phosphatidylinositol breakdown in the exocrine pancreas liberates arachidonic acid, stearic acid, and glycerol by sequential actions of phospholipase C and diglyceride lipase.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carbon Radioisotopes; Ceruletide; Cyclohexanones; Glycerol; In Vitro Techniques; Lipase; Lipoprotein Lipase; Male; Mice; Mice, Inbred ICR; Pancreas; Phosphatidylinositols; Phospholipases; Stearic Acids; Type C Phospholipases | 1984 |
Diglyceryl lipase activity in mouse platelets.
Topics: Animals; Blood Platelets; Cyclohexanones; Humans; Lipoprotein Lipase; Mice; Phospholipases A; Rats; Species Specificity; Type C Phospholipases | 1984 |
Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Calcium; Cyclohexanes; Cyclohexanones; Dogs; Kinetics; Lipoprotein Lipase; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Aggregation; Rats; Species Specificity | 1982 |
Nordihydroguaiaretic acid and RHC 80267 potentiate astroglial injury during combined glucose-oxygen deprivation.
Topics: Animals; Animals, Newborn; Antioxidants; Arachidonic Acids; Astrocytes; Cell Death; Cell Hypoxia; Cells, Cultured; Cyclohexanones; Glucose; Immunohistochemistry; L-Lactate Dehydrogenase; Lipoprotein Lipase; Masoprocol; Protease Inhibitors; Rats; Rats, Sprague-Dawley | 1995 |
Effect of the diglyceride lipase inhibitor, RG80267, on epithelial chloride secretion induced by various agents.
Topics: Alprostadil; Analysis of Variance; Arachidonic Acid; Cell Line; Chlorides; Colforsin; Colon; Cyclohexanones; Epithelium; Humans; Kinetics; Lipoprotein Lipase; Time Factors; Vasoactive Intestinal Peptide | 1995 |
AA-release is under control of PLA2 and DAG lipase in rat liver macrophages.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium; Cyclohexanones; Fluorides; Isoenzymes; Kinetics; Kupffer Cells; Lipoprotein Lipase; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Zymosan | 1995 |
Diacylglycerol hydrolysis to arachidonic acid is necessary for insulin secretion from isolated pancreatic islets: sequential actions of diacylglycerol and monoacylglycerol lipases.
Topics: Animals; Arachidonic Acid; Cyclohexanones; Diglycerides; Fatty Acids; Insulin; Insulin Secretion; Islets of Langerhans; Male; Monoacylglycerol Lipases; Rats; Rats, Sprague-Dawley; Second Messenger Systems | 1994 |
Characterisation of the second messenger pathway underlying neurite outgrowth stimulated by FGF.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Calcium; Calcium Channel Blockers; Cells, Cultured; Cerebellum; Cyclohexanones; Fibroblast Growth Factor 2; Hydroquinones; Melitten; Mice; Neurites; Neurons; Protein-Tyrosine Kinases; Second Messenger Systems; Virulence Factors, Bordetella | 1994 |
Arachidonate activation of protein kinase C may be involved in the stimulation of protein synthesis by insulin in L6 myoblasts.
Topics: Animals; Arachidonic Acid; Cell Line; Cyclohexanones; Cyclooxygenase Inhibitors; Diglycerides; Enzyme Activation; Indoles; Insulin; Lipoprotein Lipase; Muscle Proteins; Muscles; Protein Kinase C; Pyrimidinones; Rats; Thiazoles | 1993 |
Metabolism of a long-chain diacylglycerol by permeabilized A10 smooth muscle cells.
Topics: Animals; Cell Line; Cell Membrane Permeability; Cyclohexanones; Diglycerides; Lactones; Lipoprotein Lipase; Muscle, Smooth, Vascular; Orlistat | 1993 |
Differential involvement of phospholipase A2 in phorbol ester-induced luteinizing hormone and growth hormone release from rat anterior pituitary tissue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminobenzoates; Animals; Arachidonic Acid; Aristolochic Acids; Chlorobenzoates; Cinnamates; Cyclohexanones; Cycloheximide; Enzyme Activation; Female; Growth Hormone; Indoles; Ionomycin; Isoquinolines; Luteinizing Hormone; Melitten; ortho-Aminobenzoates; Phenanthrenes; Phenothiazines; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Piperazines; Pituitary Gland, Anterior; Proestrus; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Staurosporine | 1993 |
Formation of diacylglycerol, inositol phosphates, arachidonic acid and its metabolites in macrophages.
Topics: Animals; Arachidonic Acid; Calcimycin; Cells, Cultured; Cyclohexanones; Diglycerides; Fluorides; Inositol Phosphates; Macrophages; Male; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Zymosan | 1993 |
Interleukin-1 selectively potentiates bradykinin-stimulated arachidonic acid release from human synovial fibroblasts.
Topics: Arachidonic Acid; Bradykinin; Calcium; Cells, Cultured; Cyclohexanones; Cycloheximide; Cytosol; Dactinomycin; Drug Synergism; Fibroblasts; Humans; Interleukin-1; Kinetics; Protein Kinase C; Stearic Acids; Synovial Membrane; Tetradecanoylphorbol Acetate; Tritium; Type C Phospholipases | 1993 |
New patterns of diacylglycerol metabolism in intact cells.
Topics: 3T3 Cells; Animals; Cell Membrane Permeability; Cyclohexanones; Diglycerides; Lipids; Lipolysis; Lipoprotein Lipase; Mice; Phosphatidylcholines; Phosphatidylinositols; Tumor Cells, Cultured | 1993 |
Distinct signal transduction pathways for angiotensin-II in guinea pig gastric smooth muscle: differential blockade by indomethacin and tyrosine kinase inhibitors.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Calcium; Catechols; Cyclohexanones; Dose-Response Relationship, Drug; Epidermal Growth Factor; Genistein; Guinea Pigs; Imidazoles; In Vitro Techniques; Indoles; Indomethacin; Isoflavones; Losartan; Male; Muscle, Smooth; Nitriles; Protein-Tyrosine Kinases; Pyridines; Quinacrine; Signal Transduction; Stomach; Tetrazoles; Tyrphostins | 1993 |
Effect of inhibitors of eicosanoid metabolism on release of [3H]noradrenaline from the human neuroblastoma, SH-SY5Y.
Topics: Arachidonic Acid; Calcimycin; Carbachol; Cyclohexanones; Eicosanoids; Exocytosis; Humans; Linoleic Acid; Linoleic Acids; Lipase; Lipoxygenase Inhibitors; Masoprocol; Neuroblastoma; Norepinephrine; Organic Chemicals; Potassium; Tumor Cells, Cultured | 1993 |
Metabotropic glutamate receptors, transmitter output and fatty acids: studies in rat brain slices.
Topics: Acetophenones; Animals; Arachidonic Acid; Aspartic Acid; Corpus Striatum; Cyclohexanones; Cycloleucine; Cyclooxygenase Inhibitors; Fatty Acids; Glutamic Acid; In Vitro Techniques; Indomethacin; Lipoprotein Lipase; Male; Masoprocol; Membrane Potentials; Neurotoxins; Oleic Acids; Parietal Lobe; Phospholipases A; Phospholipases A2; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Serum Albumin; Stearic Acids | 1996 |
The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens.
Topics: Animals; Calcium; Carcinogens; Cyclohexanones; Diglycerides; Lipoprotein Lipase; Male; Naphthalenes; Norepinephrine; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Staurosporine; Thiazoles; Vas Deferens | 1996 |
Importance of the phospholipase D-initiated sequential pathway for arachidonic acid release and prostaglandin D2 generation by rat peritoneal mast cells.
Topics: Adenosine Diphosphate Ribose; ADP-Ribosylation Factors; Animals; Arachidonic Acid; Brain; Cattle; Choline; Cyclohexanones; Dinitrophenols; Enzyme Activation; Enzyme Inhibitors; Ethanol; GTP-Binding Proteins; Inositol; Inositol Phosphates; Ionomycin; Kinetics; Lipoprotein Lipase; Lysophosphatidylcholines; Male; Mast Cells; Melitten; Peritoneal Cavity; Phospholipase D; Propranolol; Prostaglandin D2; Rats; Rats, Wistar; Receptors, IgE; Serum Albumin, Bovine | 1996 |
Fibroblast growth factor receptor function is required for the orderly projection of ganglion cell axons in the developing mammalian retina.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Axons; Cell Adhesion Molecules; Cyclohexanones; Eye Proteins; Fetal Proteins; Mammals; Mice; Rats; Receptors, Fibroblast Growth Factor; Retina; Retinal Ganglion Cells; Signal Transduction | 1996 |
Production of [3H]choline-labelled metabolites from endogenously 3H-labelled phosphatidylcholine in mouse pancreatic islets.
Topics: Animals; Carbachol; Cells, Cultured; Choline; Cyclohexanones; Diazoxide; Glucose; Glycerylphosphorylcholine; Insulin; Insulin Secretion; Islets of Langerhans; Isoproterenol; Kinetics; Lysophosphatidylcholines; Male; Mice; Mice, Inbred Strains; Phosphatidylcholines; Potassium Chloride; Radioisotope Dilution Technique; Rats; Sodium Fluoride; Succinates; Tetradecanoylphorbol Acetate; Tolbutamide; Tritium | 1996 |
Caerulein-stimulated arachidonic acid release in rat pancreatic acini: a diacylglycerol lipase affair.
Topics: Androstadienes; Animals; Arachidonic Acid; Aristolochic Acids; Carbachol; Cells, Cultured; Ceruletide; Cyclohexanones; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Estrenes; Kinetics; Lipoprotein Lipase; Lipoxygenase Inhibitors; Male; Pancreas; Phenanthrenes; Phospholipase D; Phospholipases A; Phospholipases A2; Pyrrolidinones; Quinacrine; Rats; Rats, Sprague-Dawley; Wortmannin | 1996 |
Tyrosine kinase inhibitor-sensitive contractile action of ethanol in gastric smooth muscle: comparison with the action of epidermal growth factor.
Topics: 1-Propanol; Animals; Calcium; Catechols; Cyclohexanones; Enzyme Inhibitors; Epidermal Growth Factor; Ethanol; Fomepizole; Genistein; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Indomethacin; Isoflavones; Male; Maleimides; Methanol; Muscle Contraction; Muscle, Smooth; Nitriles; Protein-Tyrosine Kinases; Pyrazoles; Quinazolines; Signal Transduction; Stomach; Tyrphostins | 1997 |
Alpha 1-adrenoceptor activation of a non-selective cation current in rabbit portal vein by 1,2-diacyl-sn-glycerol.
Topics: Alkaloids; Animals; Benzophenanthridines; Carcinogens; Cyclohexanones; Diglycerides; Enzyme Inhibitors; Estrenes; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Inositol 1,4,5-Trisphosphate; Lipoprotein Lipase; Norepinephrine; Phenanthridines; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors; Portal Vein; Pyrrolidinones; Rabbits; Receptors, Adrenergic, alpha-1; Thionucleotides; Type C Phospholipases | 1997 |
Endogenous arachidonic acid release and pancreatic amylase secretion.
Topics: Amylases; Animals; Arachidonic Acid; Aristolochic Acids; Carbachol; Cyclohexanones; Enzyme Inhibitors; In Vitro Techniques; Lipoprotein Lipase; Male; Melitten; Pancreas; Phenanthrenes; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Sprague-Dawley | 1997 |
Use of a fluorescent analog of CDP-DAG in human skin fibroblasts: characterization of metabolism, distribution, and application to studies of phosphatidylinositol turnover.
Topics: 4-Chloro-7-nitrobenzofurazan; Cells, Cultured; Chromatography, Thin Layer; Cyclohexanones; Cytidine Diphosphate Diglycerides; Enzyme Inhibitors; Fibroblasts; Fluorescent Dyes; Humans; Interleukin-1; Lipoprotein Lipase; Membrane Lipids; Microscopy, Fluorescence; Oleic Acid; Palmitic Acid; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylinositols; Platelet-Derived Growth Factor; Propranolol; Pyrimidinones; Thiazoles | 1997 |
Mechanism of angiotensin II-induced arachidonic acid metabolite release in aortic smooth muscle cells: involvement of phospholipase D.
Topics: Angiotensin II; Animals; Aorta; Arachidonic Acid; Calcium; Cyclohexanones; Epoprostenol; Extracellular Space; Genistein; Isoflavones; Male; Muscle, Smooth, Vascular; Phospholipase D; Propranolol; Protease Inhibitors; Rats; Rats, Sprague-Dawley | 1997 |
Protein kinase C-independent activation of a novel nonspecific phospholipase C pathway by phorbol myristate acetate releases arachidonic acid for prostaglandin synthesis in MC3T3-E1 osteoblasts.
Topics: Animals; Arachidonic Acid; Carcinogens; Cell Line; Cyclohexanones; Diglycerides; Dinoprostone; Down-Regulation; Eicosanoids; Enzyme Activation; Lipoprotein Lipase; Membrane Lipids; Mice; Osteoblasts; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phospholipid Ethers; Phospholipids; Prostaglandins; Protease Inhibitors; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Type C Phospholipases | 1997 |
Inhibition of glucose-induced insulin secretion by the diacylglycerol lipase inhibitor RHC 80267 and the phospholipase A2 inhibitor ACA through stimulation of K+ permeability without diminution by exogenous arachidonic acid.
Topics: Animals; Arachidonic Acid; Cinnamates; Cyclohexanones; Diazoxide; Enzyme Inhibitors; Glucose; In Vitro Techniques; Insulin; Islets of Langerhans; Lipoprotein Lipase; Male; Mice; ortho-Aminobenzoates; Phospholipases A; Phospholipases A2; Potassium Channels; Rubidium Radioisotopes | 1997 |
Contractile action of ethanol in guinea pig gastric smooth muscle: inhibition by tyrosine kinase inhibitors and comparison with the contractile action of epidermal growth factor-urogastrone.
Topics: Animals; Calcium; Cyclohexanones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Ethanol; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Quinacrine; Stomach; Type C Phospholipases | 1997 |
Mechanism of thrombin-induced arachidonic acid release in osteoblast-like cells.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Cyclohexanones; Dinoprostone; Enzyme Inhibitors; Estrenes; Lipoprotein Lipase; Mice; Osteoblasts; Phosphatidate Phosphatase; Phospholipases A; Phospholipases A2; Propranolol; Pyrrolidinones; Quinacrine; Thrombin; Type C Phospholipases | 1997 |
Arachidonic acid release induced by extracellular ATP in osteoblasts: role of phospholipase D.
Topics: Adenosine Triphosphate; Adrenergic beta-Antagonists; Arachidonic Acid; Cell Line; Cyclohexanones; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Lipoprotein Lipase; Osteoblasts; Phosphatidylcholines; Phospholipase D; Propranolol | 1997 |
Bradykinin-stimulated cPLA2 phosphorylation is protein kinase C dependent in rabbit CCD cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Cells, Cultured; Cyclohexanones; Cytosol; Enzyme Inhibitors; Kidney Cortex; Kidney Tubules, Collecting; Kinetics; Phospholipases A; Phospholipases A2; Phosphorylation; Protease Inhibitors; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1997 |
Neurite outgrowth stimulated by neural cell adhesion molecules requires growth-associated protein-43 (GAP-43) function and is associated with GAP-43 phosphorylation in growth cones.
Topics: 3T3 Cells; Animals; Antibodies; Cells, Cultured; Coculture Techniques; Cyclohexanones; Fibroblast Growth Factors; GAP-43 Protein; Growth Cones; Mice; Mice, Knockout; Neural Cell Adhesion Molecules; Neurites; Phosphorylation; Receptors, Fibroblast Growth Factor; Recombinant Fusion Proteins; Signal Transduction; Transfection | 1998 |
Fibroblast growth factor receptor signaling in Xenopus retinal axon extension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Brain-Derived Neurotrophic Factor; Cadherins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Size; Cells, Cultured; Cyclohexanones; Fibroblast Growth Factor 2; Growth Cones; Isoenzymes; Lipoprotein Lipase; Neurites; Phospholipase C gamma; Receptors, Fibroblast Growth Factor; Retina; Second Messenger Systems; Transfection; Type C Phospholipases; Xenopus laevis | 1998 |
Regulation of lung surfactant secretion by phospholipase A2.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcimycin; Cells, Cultured; Cinnamates; Cyclohexanones; Diglycerides; Enzyme Inhibitors; Lipoprotein Lipase; Male; ortho-Aminobenzoates; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Pulmonary Alveoli; Pulmonary Surfactants; Rats; Rats, Sprague-Dawley; Terbutaline; Tetradecanoylphorbol Acetate | 1999 |
Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cyclohexanones; Diglycerides; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hydrolysis; Ionomycin; Ionophores; Lipoprotein Lipase; Mice; Neuroblastoma; Phosphatidic Acids; Phospholipase D; Phosphoric Monoester Hydrolases; Prodrugs; Protease Inhibitors; Tumor Cells, Cultured; Type C Phospholipases | 1999 |
Role of phospholipase A2 in the cytotoxic effects of oxalate in cultured renal epithelial cells.
Topics: Anesthetics, Local; Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Cell Line; Cyclohexanones; Dibucaine; Diglycerides; Dogs; Enzyme Inhibitors; Epithelial Cells; Free Radicals; Kidney Tubules, Distal; Oleic Acid; Oxalates; Phospholipases A; Phospholipases A2; Protease Inhibitors; Quinacrine; Tritium | 1999 |
N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression.
Topics: beta Catenin; Blotting, Western; Breast Neoplasms; Cadherins; Cell Movement; Cell Size; Coculture Techniques; Cyclohexanones; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression; Humans; Lipoprotein Lipase; Models, Biological; Neoplasm Invasiveness; Receptors, Fibroblast Growth Factor; Signal Transduction; Trans-Activators; Transfection; Tumor Cells, Cultured | 1999 |
CAMs and FGF cause a local submembrane calcium signal promoting axon outgrowth without a rise in bulk calcium concentration.
Topics: Animals; Axons; Barium; Calcium; Calcium Channels, L-Type; Calcium Channels, N-Type; Calcium Signaling; Cell Adhesion Molecules; Cells, Cultured; Cyclohexanones; Fibroblast Growth Factor 2; Ganglia, Spinal; Growth Cones; Ionophores; Leukocyte L1 Antigen Complex; Lipoprotein Lipase; Membrane Glycoproteins; Mice; Neural Cell Adhesion Molecules; Neurons, Afferent; Potassium Chloride; Protease Inhibitors; Rats; Valinomycin | 1999 |
[8-(Diethylamino)octyl-3,4,5-trimethoxybenzoate, HCl], the inhibitor of intracellular calcium mobilization, blocked mitogen-induced T cell proliferation by interfering with the sustained phase of protein kinase C activation.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Division; Concanavalin A; Cyclohexanones; Diglycerides; Enzyme Activation; Gallic Acid; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Ionomycin; Mice; Mice, Inbred BALB C; Naphthalenes; Protein Kinase C; Receptors, Cytoplasmic and Nuclear; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2000 |
The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Animals; Aorta; Cell Division; Cells, Cultured; Cyclohexanones; Diglycerides; Ethanol; Kinetics; Lipoprotein Lipase; Muscle, Smooth, Vascular; Phosphatidic Acids; Phospholipase D; Propranolol; Rats; Signal Transduction; Thymidine | 2000 |
Activation of cPLA2 in vascular smooth muscle.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arteries; Cyclohexanones; Enzyme Activation; Enzyme Inhibitors; Estrenes; In Vitro Techniques; Isoenzymes; Lipoprotein Lipase; Muscle, Smooth, Vascular; Naphthalenes; Norepinephrine; Phospholipases A; Pyrones; Pyrrolidinones; Rats; Terpenes; Type C Phospholipases | 1999 |
Apamin-sensitive, non-nitric oxide (NO) endothelium-dependent relaxations to bradykinin in the bovine isolated coronary artery: no role for cytochrome P450 and K+.
Topics: Animals; Apamin; Arachidonic Acid; Arachidonic Acids; Biological Factors; Bradykinin; Cattle; Coronary Vessels; Cromakalim; Cyclohexanones; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Ouabain; Oxazines; Potassium; Potassium Chloride; Protease Inhibitors | 2000 |
Apical endocytosis of ricin in MDCK cells is regulated by the cyclooxygenase pathway.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Line; Cell Polarity; Cyclic AMP-Dependent Protein Kinases; Cyclohexanones; Cyclooxygenase Inhibitors; Dogs; Endocytosis; Enzyme Activation; Enzyme Inhibitors; Heterotrimeric GTP-Binding Proteins; Intercellular Signaling Peptides and Proteins; Ionomycin; Lipoprotein Lipase; Lipoxygenase Inhibitors; Organophosphonates; Peptides; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Kinase C; Ricin; Signal Transduction; Tetradecanoylphorbol Acetate; Wasp Venoms | 2000 |
The role of diacylglycerol as a modulator of oxytocin-stimulated phasic contractions in myometrium from pregnant and nonpregnant rats.
Topics: Animals; Cyclohexanones; Diacylglycerol Kinase; Diglycerides; Enzyme Inhibitors; Female; Lipoprotein Lipase; Myometrium; Oxytocin; Pregnancy; Pregnancy, Animal; Pyrimidinones; Rats; Rats, Sprague-Dawley; Reference Values; Thiazoles; Uterine Contraction | 2000 |
Diacylglycerol mediates the T-cell receptor-driven Ca(2+) influx in T cells by a novel mechanism independent of protein kinase C activation.
Topics: Animals; Calcium Signaling; Cyclohexanones; Diglycerides; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Lipoprotein Lipase; Mice; Mice, Inbred BALB C; Naphthalenes; Nickel; Protein Kinase C; Pyrimidinones; Receptors, Antigen, T-Cell; T-Lymphocytes; Thiazoles | 2000 |
20-Hydroxyeicosatetraenoic acid mediates angiotensin ii-induced phospholipase d activation in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Arachidonic Acids; Cells, Cultured; Ceramides; Cyclohexanones; Enzyme Inhibitors; Glycerophospholipids; Hydroxyeicosatetraenoic Acids; Isoenzymes; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Oligonucleotides, Antisense; Organophosphonates; Phospholipase D; Propranolol; Rabbits | 2001 |
Signalling mechanisms underlying the myogenic response in human subcutaneous resistance arteries.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aged; Analysis of Variance; Arteries; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Transporting ATPases; Cyclohexanones; Enzyme Inhibitors; Estrenes; Female; Humans; In Vitro Techniques; Indoles; Lipoprotein Lipase; Male; Middle Aged; Muscle, Smooth, Vascular; Naphthalenes; Nifedipine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrrolidinones; Ryanodine; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Type C Phospholipases; Vascular Resistance | 2001 |
Melittin exerts multiple effects on the release of free fatty acids from L1210 cells: lack of selective activation of phospholipase A2 by melittin.
Topics: Animals; Arachidonic Acid; Calcium; Cell Line; Cell Membrane Permeability; Cyclohexanones; Digitonin; Enzyme Activation; Enzyme Inhibitors; Estrenes; Ethidium; Fatty Acids, Nonesterified; Humans; Leukemia L1210; Lipoprotein Lipase; Melitten; Mice; Palmitic Acid; Phospholipases A; Phospholipases A2; Pyrrolidinones; Type C Phospholipases | 2001 |
In vivo mechanisms of vascular endothelial growth factor-mediated increased hydraulic conductivity of Rana capillaries.
Topics: Adenosine Triphosphate; Animals; Capillaries; Capillary Permeability; Cyclohexanones; Endothelial Growth Factors; Enzyme Inhibitors; Estrenes; Indoles; Isoenzymes; Lipoprotein Lipase; Lymphokines; Male; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphodiesterase Inhibitors; Phospholipase C gamma; Phosphorylation; Protease Inhibitors; Protein Kinase C; Pyrrolidinones; Rana temporaria; Type C Phospholipases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Chlorpyrifos oxon potentiates diacylglycerol-induced extracellular signal-regulated kinase (ERK 44/42) activation, possibly by diacylglycerol lipase inhibition.
Topics: Animals; Cell Line; Cell Membrane Permeability; Chlorpyrifos; CHO Cells; Cricetinae; Cyclohexanones; Diglycerides; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Lipoprotein Lipase; Mitogen-Activated Protein Kinases; Phosphorylation; Protease Inhibitors; Pseudomonas; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors | 2002 |
Endothelin-1-induced arachidonic acid release by cytosolic phospholipase A2 activation in rat vascular smooth muscle via extracellular signal-regulated kinases pathway.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arteries; Carrier Proteins; Cyclohexanones; Drug Interactions; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Norepinephrine; Phospholipases A; Phospholipases A2; Phosphorylation; Rats; Rats, Wistar; Tail; Tritium | 2002 |
Arachidonic acid mobilization by phospholipase D in the contraction induced by phenylephrine in rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Abdominal; Aorta, Thoracic; Arachidonic Acid; Cyclohexanones; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Phospholipase D; Rats; Rats, Wistar | 2002 |
Store operated Ca2+ influx by selective depletion of ryanodine sensitive Ca2+ pools in primary human skeletal muscle cells.
Topics: Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Cyclohexanones; Diglycerides; Humans; Lipoprotein Lipase; Magnesium; Muscle Cells; Muscle, Skeletal; Nifedipine; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; Ryanodine; Ryanodine Receptor Calcium Release Channel; Time Factors; Type C Phospholipases | 2003 |
Effects of RHC-80267, an inhibitor of diacylglycerol lipase, on excitation of circular smooth muscle of the guinea-pig gastric antrum.
Topics: Acetylcholine; Animals; Cyclohexanones; Electric Impedance; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Lipoprotein Lipase; Male; Muscle, Smooth; Nervous System Physiological Phenomena; Pyloric Antrum; Reaction Time; Refractory Period, Electrophysiological | 2002 |
Antimicrobial activity of clofazimine is not dependent on mycobacterial C-type phospholipases.
Topics: Anti-Infective Agents; Arachidonic Acid; Clofazimine; Cyclohexanones; Gene Deletion; Hydrolysis; Lipoprotein Lipase; Mycobacterium smegmatis; Mycobacterium tuberculosis; Rubidium Radioisotopes; Type C Phospholipases | 2004 |
Brain phospholipase C-diacylglycerol lipase pathway is involved in vasopressin-induced release of noradrenaline and adrenaline from adrenal medulla in rats.
Topics: Adrenal Medulla; Animals; Brain; Catecholamines; Cyclohexanones; Dose-Response Relationship, Drug; Epinephrine; Estrenes; Injections, Intraventricular; Lipoprotein Lipase; Male; Neomycin; Norepinephrine; Phospholipases A; Phospholipases A2; Pyrrolidinones; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Time Factors; Type C Phospholipases; Vasopressins | 2004 |
Capsazepine, a vanilloid antagonist, abolishes tonic responses induced by 20-HETE on guinea pig airway smooth muscle.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Bronchi; Calcium; Calcium Channels; Capsaicin; Cyclohexanones; Cytochrome P-450 CYP4A; Female; Guinea Pigs; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Intracellular Membranes; Lipoprotein Lipase; Male; Muscle Contraction; Muscle, Smooth; Protease Inhibitors; Receptors, Drug; Time Factors; Trachea | 2005 |
2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion.
Topics: Androgens; Arachidonic Acids; Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases; Cyclohexanones; Endocannabinoids; Glycerides; Humans; Hydrolysis; Lipoprotein Lipase; Male; Neoplasm Invasiveness; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptor, Cannabinoid, CB1 | 2004 |
Brain phospholipase C/diacylglycerol lipase are involved in bombesin BB2 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.
Topics: Adrenal Medulla; Animals; Arachidonic Acid; Bombesin; Brain; Cyclohexanones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Estrenes; Gastrin-Releasing Peptide; Injections, Intraventricular; Lipoprotein Lipase; Male; Neurokinin B; Norepinephrine; Peptides, Cyclic; Phospholipases A; Phospholipases A2; Pyrrolidinones; Quinacrine; Rats; Rats, Wistar; Receptors, Bombesin; Sympathetic Nervous System; Type C Phospholipases | 2005 |
The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action.
Topics: Acetylcholine; Animals; Biological Factors; Cholinesterase Inhibitors; Cholinesterases; Cromakalim; Cyclohexanones; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Lipoprotein Lipase; Male; Mesenteric Arteries; Naphthalenes; Neostigmine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Norepinephrine; Penicillamine; Phospholipases A; Protein Kinase C; Rats; Rats, Inbred WKY; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
Role of phospholipase C and diacylglyceride lipase pathway in arachidonic acid release and acetylcholine-induced vascular relaxation in rabbit aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Carbamates; Cells, Cultured; Cyclohexanones; Diazomethane; Endothelium, Vascular; Estrenes; In Vitro Techniques; Indomethacin; Isoenzymes; Lipoprotein Lipase; Methacholine Chloride; Nitroarginine; Phospholipases A; Phospholipases A2; Pyrrolidinones; Rabbits; Type C Phospholipases; Vasodilation | 2006 |
Characterization of the lipolytic pathways that mediate free fatty acid release during Fas/CD95-induced apoptosis.
Topics: Apoptosis; Arachidonic Acids; Bridged-Ring Compounds; Cyclohexanones; Endocannabinoids; Enzyme Inhibitors; fas Receptor; Fatty Acids, Nonesterified; Glycerides; Humans; Jurkat Cells; Ketones; Lipid Metabolism; Lipolysis; Lipoprotein Lipase; Models, Biological; Norbornanes; Palmitic Acid; Phosphatidic Acids; Phosphatidylcholines; Thiocarbamates; Thiones; Type C Phospholipases | 2005 |
Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability.
Topics: Calcium; Cell Line; Cell Membrane Permeability; Cyclohexanones; Diglycerides; Electrophysiology; Estrenes; Humans; Kidney; Membrane Potentials; Models, Biological; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Potassium; Protease Inhibitors; Pyrrolidinones; Signal Transduction; Sodium; TRPC Cation Channels; TRPC6 Cation Channel | 2006 |
Effect of chronic hypoxia on voltage-independent calcium influx activated by 5-HT in rat intrapulmonary arteries.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Chronic Disease; Cyclohexanones; Drug Resistance; Electrophysiology; Gadolinium; Hypoxia; In Vitro Techniques; Intracellular Membranes; Lipoprotein Lipase; Male; Myocytes, Smooth Muscle; Nitrendipine; Pulmonary Artery; Rats; Rats, Wistar; Serotonin; TRPC Cation Channels; Vasoconstriction; Vasoconstrictor Agents | 2007 |
Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats.
Topics: Adrenal Medulla; Animals; Arachidonic Acid; Brain; Bridged-Ring Compounds; Cyclohexanones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Estrenes; Histamine; Injections, Intraventricular; Lipoprotein Lipase; Male; Norbornanes; Norepinephrine; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phospholipases A; Phospholipases A2; Phospholipid Ethers; Pyrrolidinones; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Thiocarbamates; Thiones; Time Factors | 2007 |
Bidirectional roles of the brain 2-arachidonoyl-sn-glycerol in the centrally administered vasopressin-induced adrenomedullary outflow in rats.
Topics: Adrenal Medulla; Animals; Arachidonic Acids; Arginine Vasopressin; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Catecholamines; Cyclohexanones; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Epinephrine; Glycerides; Indoles; Injections, Intraventricular; Male; Morpholines; Naphthalenes; Norepinephrine; Organophosphonates; Piperidines; Pyrazoles; Rats; Rats, Wistar | 2008 |
L- and N-current but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity.
Topics: Animals; Arachidonic Acids; Calcium Channels, L-Type; Calcium Channels, N-Type; Cells, Cultured; Cyclohexanones; Humans; In Situ Hybridization; Lipoprotein Lipase; Muscarinic Agonists; Neurons; Oxotremorine; Patch-Clamp Techniques; Pertussis Toxin; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Muscarinic M1; Recombinant Proteins; Superior Cervical Ganglion | 2008 |
Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling.
Topics: Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Cyclohexanones; Endocannabinoids; Glycerides; Humans; Isoenzymes; Lactones; Lipase; Molecular Structure; Orlistat; Receptor, Cannabinoid, CB1; Serine Proteinase Inhibitors | 2008 |
Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons.
Topics: Aniline Compounds; Animals; Bridged Bicyclo Compounds; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebral Cortex; Cyclohexanones; Diglycerides; Embryo, Mammalian; Enzyme Inhibitors; Fura-2; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Phloroglucinol; Potassium Chloride; Second Messenger Systems; Sodium; Terpenes; TRPC Cation Channels; Xanthenes | 2009 |
Distinct functional and anatomical architecture of the endocannabinoid system in the auditory brainstem.
Topics: Animals; Animals, Newborn; Auditory Pathways; Benzoxazines; Biophysics; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cochlear Nucleus; Cyclohexanones; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; In Vitro Techniques; Lipoprotein Lipase; Membrane Potentials; Mice; Mice, Inbred ICR; Microscopy, Immunoelectron; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Protease Inhibitors; Pyrazoles; Receptor, Cannabinoid, CB1; Synaptic Potentials; Time Factors | 2009 |
Age-related changes in the metabolization of phosphatidic acid in rat cerebral cortex synaptosomes.
Topics: Aging; Animals; Ceramides; Cerebral Cortex; Cyclohexanones; Diglycerides; Glycerol; Lipid Metabolism; Lipoprotein Lipase; Lysophospholipids; Male; Monoglycerides; Phosphatidate Phosphatase; Protease Inhibitors; Rats; Rats, Wistar; Sphingosine; Synaptosomes | 2009 |
Diacylglycerol lipase is not involved in depolarization-induced suppression of inhibition at unitary inhibitory connections in mouse hippocampus.
Topics: Animals; Animals, Newborn; Benzoxazines; Cyclohexanones; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Antagonists; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lipoprotein Lipase; Lysine; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Neocortex; Neural Inhibition; Neurons; Pyridazines; Quinoxalines; Receptor, Cannabinoid, CB1; Valine | 2010 |
Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor.
Topics: Animals; Cannabinoid Receptor Modulators; Cyclohexanones; Electrophysiology; Endocannabinoids; Leeches; Lipoprotein Lipase; Long-Term Synaptic Depression; Nociceptors; Protease Inhibitors; Synapses; TRPV Cation Channels | 2010 |
Inhibitors of diacylglycerol metabolism reduce time to the onset of glutamate release potentation by mGlu7 receptors.
Topics: Animals; Cerebral Cortex; Cyclohexanones; Diacylglycerol Kinase; Diglycerides; Glutamic Acid; In Vitro Techniques; Mice; Receptors, Metabotropic Glutamate; Synaptosomes; Time Factors | 2011 |
Molecular characterization and identification of surrogate substrates for diacylglycerol lipase α.
Topics: Catalysis; Cell Membrane; Chromogenic Compounds; Cyclohexanones; Fluorescence; HEK293 Cells; Humans; Lactones; Lipoprotein Lipase; Mutation; Orlistat; Substrate Specificity | 2011 |
Polymodal activation of the endocannabinoid system in the extended amygdala.
Topics: Animals; Arachidonic Acids; Biophysics; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cannabinoid Receptor Modulators; Chromones; Cyclohexanones; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycerides; In Vitro Techniques; Long-Term Synaptic Depression; Neurons; Nimodipine; Patch-Clamp Techniques; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Septal Nuclei; Signal Transduction; Synapses; Time Factors; TRPV Cation Channels | 2011 |
Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia.
Topics: Analgesia; Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cyclohexanones; Dose-Response Relationship, Drug; Electroconvulsive Therapy; Endocannabinoids; Excitatory Amino Acid Antagonists; Glycerides; Lipoprotein Lipase; Male; Methoxyhydroxyphenylglycol; Mice; Microscopy, Immunoelectron; Pain; Periaqueductal Gray; Piperidines; Protease Inhibitors; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rimonabant; RNA, Messenger; RNA, Small Interfering; Synapses; Tandem Mass Spectrometry | 2012 |
Brain phospholipase C, diacylglycerol lipase and monoacylglycerol lipase are involved in (±)-epibatidine-induced activation of central adrenomedullary outflow in rats.
Topics: Adrenal Medulla; Animals; Arachidonic Acids; Benzodioxoles; Brain; Bridged Bicyclo Compounds, Heterocyclic; Catecholamines; Cyclohexanones; Esterases; Estrenes; Lipoprotein Lipase; Male; Monoacylglycerol Lipases; Neurons; Nicotinic Agonists; Organophosphonates; Paraventricular Hypothalamic Nucleus; Piperidines; Pyridines; Pyrrolidinones; Rats; Rats, Wistar; Type C Phospholipases | 2012 |
Disease-modifying effects of RHC80267 and JZL184 in a pilocarpine mouse model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Benzodioxoles; Cyclohexanones; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Exploratory Behavior; Hindlimb Suspension; Hippocampus; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Piperidines | 2014 |
Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling.
Topics: Aging; Animals; Benzoxazines; Cannabinoid Receptor Antagonists; Cyclohexanones; Gene Expression Regulation; Hippocampus; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Lipoprotein Lipase; Mice; Mice, Knockout; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Small Interfering; Seizures; Seizures, Febrile; Signal Transduction; Tissue Culture Techniques | 2016 |
Cytosolic Phospholipase A
Topics: Animals; Arachidonic Acid; Bacteremia; Cell Line, Tumor; Chemotactic Factors; Chlorobenzoates; Cinnamates; Cyclohexanones; Enzyme Inhibitors; Epithelial Cells; Group IV Phospholipases A2; Host-Pathogen Interactions; Humans; Lung; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophil Infiltration; Neutrophils; ortho-Aminobenzoates; Pneumococcal Infections; Pneumonia, Bacterial; Streptococcus pneumoniae; Survival Analysis; Transendothelial and Transepithelial Migration | 2017 |
Fatty acid amide hydrolase (FAAH) inhibitor PF-3845 reduces viability, migration and invasiveness of human colon adenocarcinoma Colo-205 cell line: an in vitro study.
Topics: Adenocarcinoma; Amidohydrolases; Antineoplastic Agents; Benzodioxoles; Cell Line, Tumor; Cell Movement; Cell Survival; Colonic Neoplasms; Cyclohexanones; Enzyme Inhibitors; Humans; Piperidines; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2017 |
Modulation of the endocannabinoid system by the fatty acid amide hydrolase, monoacylglycerol and diacylglycerol lipase inhibitors as an attractive target for secretory diarrhoea therapy.
Topics: Amidohydrolases; Animals; Benzodioxoles; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanones; Diarrhea; Endocannabinoids; Enzyme Inhibitors; Indoles; Lipoprotein Lipase; Male; Mice; Monoglycerides; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2017 |