1-4-dihydroquinoline and quinoline

1-4-dihydroquinoline has been researched along with quinoline* in 1 studies

Other Studies

1 other study(ies) available for 1-4-dihydroquinoline and quinoline

Article	Year
Design of new hybrid template by linking quinoline, triazole and dihydroquinoline pharmacophoric groups: A greener approach to novel polyazaheterocycles as cytotoxic agents. Bioorganic & medicinal chemistry letters, 2015, Mar-01, Volume: 25, Issue:5 A new hybrid template designed by linking three pharmacophoric groups, for example, quinoline, triazole and dihydroquinoline moieties have been used for the generation of a library of molecules as potential cytotoxic agents. Synthesis of these polyazaheterocycles were carried out by using a strategy that involved one-pot sequential azidation and CuAAC in water under mild conditions. A number of 1,4-disubstituted 1,2,3-triazoles possessing quinolinylmethylene at N-1 and 1,2-dihydroquinolinyl methylene at C-4 as different substituents were synthesized and evaluated for their cytotoxic effects against various cancer cells. Some of them showed encouraging activities against lung cancer cells and one of them showed inhibition of PDE4 indicating the potential medicinal value of these novel polyazaheterocycles. Topics: Antineoplastic Agents; Aza Compounds; Azides; Cell Line, Tumor; Drug Design; Green Chemistry Technology; Humans; Molecular Docking Simulation; Neoplasms; Phosphodiesterase 4 Inhibitors; Quinolines; Triazoles	2015

Article

Year

Design of new hybrid template by linking quinoline, triazole and dihydroquinoline pharmacophoric groups: A greener approach to novel polyazaheterocycles as cytotoxic agents.

Bioorganic & medicinal chemistry letters, 2015, Mar-01, Volume: 25, Issue:5

A new hybrid template designed by linking three pharmacophoric groups, for example, quinoline, triazole and dihydroquinoline moieties have been used for the generation of a library of molecules as potential cytotoxic agents. Synthesis of these polyazaheterocycles were carried out by using a strategy that involved one-pot sequential azidation and CuAAC in water under mild conditions. A number of 1,4-disubstituted 1,2,3-triazoles possessing quinolinylmethylene at N-1 and 1,2-dihydroquinolinyl methylene at C-4 as different substituents were synthesized and evaluated for their cytotoxic effects against various cancer cells. Some of them showed encouraging activities against lung cancer cells and one of them showed inhibition of PDE4 indicating the potential medicinal value of these novel polyazaheterocycles.

Topics: Antineoplastic Agents; Aza Compounds; Azides; Cell Line, Tumor; Drug Design; Green Chemistry Technology; Humans; Molecular Docking Simulation; Neoplasms; Phosphodiesterase 4 Inhibitors; Quinolines; Triazoles

2015