1,4-dihydropyridine has been researched along with dihydropyridines in 1063 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 182 (17.12) | 18.7374 |
| 1990's | 384 (36.12) | 18.2507 |
| 2000's | 255 (23.99) | 29.6817 |
| 2010's | 210 (19.76) | 24.3611 |
| 2020's | 32 (3.01) | 2.80 |
| Authors | Studies |
|---|---|
| Cherksey, B; Llinás, R; Sugimori, M; Usowicz, MM | 1 |
| Brenner, R; Ellis, SB; Feldman, DH; Harpold, MM; McCue, AF; Velicelebi, G; Williams, ME | 1 |
| Artalejo, CR; Fox, AP; Perlman, RL | 1 |
| Reider, N; Zernig, G | 1 |
| Glossmann, H; Haugland, RP; Kang, HC; Knaus, HG; Moshammer, T | 1 |
| Armstrong, DN; Ballantyne, GH; Modlin, IM | 1 |
| Chin, H; Kim, H; Kim, HL; Smith, MA | 1 |
| Christen, MO; Feron, O; Godfraind, T; Wibo, M | 1 |
| Bernheim, L; Hille, B; Mathie, A | 1 |
| Marmé, D; Woscholski, R | 1 |
| Carrier, GO; Ikeda, SR | 1 |
| Levis, R; Ríos, E; Shirokov, R; Shirokova, N | 1 |
| Fekete, Z; Liu, J; Slomiany, A; Slomiany, BL; Yao, P | 1 |
| Chin, H; Kim, H; Kim, HL; Kozak, CA; Mock, B | 1 |
| Barrett, PQ; Isales, CM; Lewicki, JA; Nee, JJ | 1 |
| Kokubun, S; Nishimura, S; Takahashi, M; Takeshima, H; Yoshida, A | 1 |
| Beam, KG; Mynlieff, M | 1 |
| Abe, T; Hatanaka, Y; Ide-Yamada, T; Kanaoka, Y; Kuniyasu, A; Nakayama, H; Oka, K | 1 |
| Dooley, DJ | 1 |
| Marks, AR | 1 |
| Bilodeau, L; Durroux, T; Gallo-Payet, N; Payet, MD | 1 |
| Howlett, SE; Nicholl, PA | 1 |
| Bick, IR; Felix, JP; Garcia, ML; Kaczorowski, GJ; King, VF; Shevell, JL; Slaughter, RS | 1 |
| Abe, T; Anzai, K; Kirino, Y; Tokumaru, H | 1 |
| Fekete, Z; Liu, J; Murty, VL; Slomiany, A; Slomiany, BL | 1 |
| Brodie, SG; Chambers, JP; Kumar, P; Menendez-Pelaez, A; Reiter, RJ; Vaughan, MK | 1 |
| Medvedev, OS; Medvedeva, NA; Sheffer, R | 1 |
| Chin, H; Kim, HL; Kozak, CA; Krall, M; Mock, B | 1 |
| Zernig, G | 1 |
| Cherksey, BD; Llinás, R; Protti, DA; Sanchez, V; Sugimori, M; Uchitel, OD | 1 |
| Cullen, MH; Ferry, DR; Russell, MA | 1 |
| Kotlikoff, MI; Kume, H; Tomasic, M | 1 |
| Bodi, I; Itagaki, K; Klöckner, U; Koch, WJ; Schwartz, A; Slish, DF | 1 |
| Goldmann, S; Stoltefuss, J; Triggle, DJ; Zheng, W | 1 |
| Brayden, JE; Nelson, MT | 1 |
| Baumgarten, LB; Toscas, K; Villereal, ML | 1 |
| Ambroz, C; Catt, KJ | 1 |
| Taglietti, V; Toselli, M | 1 |
| Dolphin, AC; Sweeney, MI | 1 |
| Latifpour, J; Weiss, RM; Yoshida, M | 1 |
| Benterbusch, R; Herberg, FW; Melzer, W; Thieleczek, R | 1 |
| Coburn, RA; Mager, PP; Rothe, H; Solo, AJ; Triggle, DJ | 1 |
| Adams, ME; Cohen, CJ; Ertel, EA; Leibowitz, MD; Smith, MM; Venema, VJ | 1 |
| Bladen, C; Dunn, SM | 2 |
| Sullivan, JP; Tipton, KF | 1 |
| Somasundaram, B; Tregear, RT; Trentham, DR | 1 |
| Hess, P; Plummer, MR | 1 |
| Ketchum, KA; Poole, RJ | 1 |
| Flanagan, JL; Friedman, PA | 1 |
| Hayashi, T; Miyabo, S; Nakai, T | 1 |
| Dobrota, D; Drgová, A; Lehotský, J; Mézesová, V | 1 |
| Biel, M; Dascal, N; Flockerzi, V; Freundner, S; Hofmann, F; Hullin, R; Singer, D | 1 |
| Gregg, RG; Hogan, K; Lalley, PA; Liao, M; Powers, PA | 1 |
| Catterall, WA; Glossmann, H; Kanaoka, Y; Nakayama, H; Striessnig, J; Taki, M | 1 |
| Campbell, KP; Jay, SD; Pragnell, M; Sakamoto, J | 1 |
| Gollasch, M; Hescheler, J; Offermanns, S; Rosenthal, W; Schmidt, A; Schultz, G; Spicher, K | 1 |
| Bork, P; Rohde, K | 1 |
| Frey, MJ; Lanoce, V; Liang, BT; Manning, DR; Marzo, KP; Molinoff, PB; Wilson, JR | 1 |
| Bravo, G; Godfraind, T; Wibo, M | 1 |
| Little, HJ | 2 |
| Mironneau, C; Mironneau, J; Rakotoarisoa, L; Sayet, I | 1 |
| Ashcroft, FM | 1 |
| Astier, H; Bulant, M; Hollande, F; Roussel, JP | 1 |
| Ciardo, A; Meldolesi, J | 1 |
| Birnbaumer, L; Codina, J; Frank, R; Gausepohl, H; Hescheler, J; Hinsch, KD; Klinz, FJ; Offermanns, S; Schmidt, A; Spicher, K | 1 |
| Shen, KZ; Surprenant, A | 1 |
| Hescheler, J; Krautwurst, D; Meyer, R; Plant, S; Rosenthal, W; Schultz, G | 1 |
| Cuccaro, ML; Jacobs, LS; Lorenson, MY | 1 |
| Furukawa, T; Katsuragi, T; Ogawa, S; Shirakabe, K; Soejima, O | 1 |
| Brennan, CH; Littleton, JM | 1 |
| Bacskai, BJ; Friedman, PA | 1 |
| Tanabe, T | 1 |
| Kunze, DL; Ritchie, AK | 1 |
| Peers, C | 1 |
| Fox, AP; Hirning, LD; Miller, RJ | 1 |
| Florio, T; Grimaldi, M; Landolfi, E; Meucci, O; Schettini, G; Scorziello, A; Ventra, C | 1 |
| Dubyak, GR; Jones, SW; Marks, TN | 1 |
| Fox, AP; Scroggs, RS | 1 |
| Singer, JJ; Vivaudou, MB; Walsh, JV | 1 |
| Regan, LJ | 1 |
| Lory, P; Schultz, D; Schwartz, A; Varadi, G; Varadi, M | 1 |
| Brocklehurst, KW; Ceña, V; Pollard, HB; Rojas, E | 1 |
| Homaidan, FR; Nowak, LM; Sharp, GW | 1 |
| Suszkiw, JB; Tomsig, JL | 1 |
| Lin, F; Moran, O; Sciancalepore, M; Zegarra-Moran, O | 1 |
| Drímal, J | 1 |
| Rose, U | 1 |
| Dubur, GIa; Germane, SK; Glebov, RN; Karpova, MN; Klusha, VE; Pankov, OIu | 1 |
| Rudin, M; Sauter, A | 1 |
| Bezáková, G; Krizanová, O; Lehotský, J; Mézesová, V | 1 |
| Fujimoto, M; Mihara, S | 1 |
| Dunn, MJ; Simonson, MS | 1 |
| Godfraind, T; Noël, F; Wibo, M | 1 |
| Ebata, H; Mitsuhashi, T; Natsume, T; Yaginuma, T | 1 |
| Bean, BP; Regan, LJ; Sah, DW | 1 |
| Campbell, KP; Harpold, MM; Jay, SD; Kahl, SD; Sharp, AH; Vedvick, TS | 1 |
| Fill, M; Mejía-Alvarez, R; Stefani, E | 1 |
| Brunk, UT; Yin, DZ | 1 |
| Bittar, EE; Nwoga, J | 1 |
| George, PR; Harrison, TM; Kowalski, MT; Norman, RI; Wray, DW | 1 |
| Cutler, NR; Gandhi, DK; Heller, AH; Kurtz, NM; Lynch, TE; Pourdihimi Zolnouni, P; Sramek, JJ | 1 |
| Kiue, A; Kohno, K; Kuwano, M; Takano, H; Watanabe, Y | 1 |
| Ashimori, A; Eda, M; Fujino, Y; Inoue, Y; Kido, H; Morimoto, S; Ogura, Y; Ohtaki, Y; Ono, T; Uchida, T | 1 |
| Baillie, TA; Boddy, AV; Lepage, F; Levy, RH; Slatter, JG; Tombret, F; Zhang, K | 1 |
| Ebata, H; Johnson, JD; Mills, JS; Nemcek, K | 1 |
| Nord, EP; Sidell, N; Verity, MA | 1 |
| McDonald, TF; Pelzer, D; Pelzer, S | 1 |
| Fitzpatrick, LA; Jones, JI | 1 |
| Beam, KG; Mikami, A; Numa, S; Tanabe, T | 1 |
| Koch, WJ; McKenna, E; Schwartz, A; Slish, DF | 1 |
| Fujimoto, Y; Nakamura, T; Takahashi, M; Takisawa, H; Yoshida, A | 1 |
| Glossmann, H; Knaus, HG; Romanin, C; Scheffauer, F; Schindler, HG | 1 |
| Ahlijanian, MK; Catterall, WA; Westenbroek, RE | 2 |
| Marban, E; Yue, DT | 1 |
| Barker, JL; Eiden, LE; Lewis, DL; Rausch, DM | 1 |
| Hess, P; Pietrobon, D | 1 |
| Dunn, MJ; Osanai, T; Simonson, MS | 1 |
| Dale, N; Edmonds, B; Kandel, ER; Klein, M | 1 |
| Langs, DA; Strong, PD; Triggle, DJ | 1 |
| McCarty, NA; O'Neil, RG | 1 |
| Cognard, C; Duport, G; Raymond, G; Rideau, Y; Rivet, M | 1 |
| Guengerich, FP; Kim, DH | 1 |
| Hosey, MM; McMahon, KK; Ptasienski, J | 1 |
| Carpenter, CL; Cooper, EC; Greenberg, DA | 1 |
| Lee, HR; Roeske, WR; Watson, M; Yamamura, HI | 1 |
| Brown, AM; Dumont, L; Grupp, G; Grupp, IL; Hamilton, S; Schwartz, A; Vaghy, PL; Williams, JS; Yatani, A | 1 |
| Schramm, M; Towart, R | 1 |
| Litzinger, MJ; Nelson, PG; Pun, RY | 1 |
| Cognard, C; Lazdunski, M; Romey, G | 1 |
| Creba, JA; Karobath, M | 1 |
| Glossmann, H; Goll, A; Moosburger, K; Striessnig, J | 1 |
| Ferry, DR; Glossmann, H; Goll, A; Striessnig, J; Zernig, G | 1 |
| Callewaert, G; Droogmans, G | 1 |
| Kongsamut, S; Miller, RJ | 1 |
| Barhanin, J; Borsotto, M; Coppola, T; Lazdunski, M; Schmid, A | 1 |
| Ribeiro, JA; Sebastião, AM | 1 |
| Bean, BP; Hermsmeyer, K; Puga, A; Sturek, M | 1 |
| Bean, BP; Hess, P; Lansman, JB; Nilius, B; Nowycky, MC; Tsien, RW | 1 |
| Brown, AM; Hamilton, SL; Yatani, A | 1 |
| Miller, RJ; Murphy, SN; Thayer, SA | 1 |
| Becker, C; Kokubun, S; Porzig, H; Prod'hom, B; Reuter, H | 1 |
| Hoffmeister, F; Tettenborn, D | 1 |
| Chin, JH | 1 |
| Chernow, B; Ives, N; King, JW; Roth, BL | 1 |
| Barhanin, J; Cooper, CL; Fosset, M; Hosey, MM; Lazdunski, M; Vandaele, S | 1 |
| Azimi-Zonooz, A; Cruz, LJ; Galyean, R; Gray, WR; McIntosh, JM; Olivera, BM; Rivier, J | 1 |
| Decker, N; Grima, M; Schwartz, J | 1 |
| Gurney, AM; Nerbonne, JM | 1 |
| Atwal, KS; Bergey, JL; Hedberg, A; Moreland, S | 1 |
| Baldwin, JJ; Claremon, DA; Faison, EP; Kaczorowski, GJ; Lumma, PK; McClure, DE; Rosenthal, SA; Smith, GM; Trumble, MJ; Winquist, RJ | 1 |
| Brown, AM; Brush, K; Hamilton, SL; Schwartz, A; Yatani, A | 1 |
| Allen, J; Brown, AM; Seidel, CL; Yatani, A | 1 |
| Coronado, R; Gillespie, GY; Malouf, NN; McMahon, D; Meissner, G | 1 |
| Brennan, CH; Charles, S; Hudspith, MJ; Littleton, JM | 1 |
| Scriabine, A | 1 |
| Challoner-Hue, L; Steele, TH | 1 |
| Epstein, M; Horton, C; Loutzenhiser, R | 1 |
| Federmann, A; Garthoff, B; Hirth, C; Kazda, S; Stasch, JP | 1 |
| Hosey, MM; Maan, AC | 1 |
| Froehner, SC; Morton, ME | 2 |
| Dunlap, K; Holz, GG; Rane, SG | 1 |
| Bacher, J; Bolger, GT; Isaac, L; Weissman, BA | 1 |
| Janis, RA; Luchowski, E; Rampe, D; Rutledge, A; Triggle, DJ | 1 |
| Catterall, WA; Takahashi, M | 1 |
| Atchison, WD; O'Leary, SM | 1 |
| Skattebøl, A; Triggle, DJ | 1 |
| Fossheim, R | 1 |
| Brisac, AM; Champeroux, P; Gerard, P; Huguet, F; Laurent, S; Lucet, B; Montastruc, JL; Narcisse, G; Schmitt, H | 1 |
| Dunlap, K; Holz, GG; Kream, RM | 1 |
| Catterall, WA; Seagar, MJ; Takahashi, M | 1 |
| Oswald, RE; Simasko, SM; Weiland, GA | 1 |
| Askanas, V; Desnuelle, C; Engel, WK | 1 |
| Cadet, JL; Freed, WJ; Taylor, E | 1 |
| Bacciottini, L; Carlà, V; Moroni, F; Pellegrini-Giampietro, DE | 1 |
| Knepel, W; Meier, K; Schöfl, C | 1 |
| Hess, P; Pietrobon, D; Prod'hom, B | 2 |
| Chernyuk, NN; Dudkin, SM; Gnedoj, SN; Soldatov, NM | 1 |
| Birnbaumer, L; Brown, AM; Codina, J; Hamilton, SL; Imoto, Y; Yatani, A | 1 |
| Warbanow, W; Will-Shahab, L | 1 |
| Hawthorn, M; Hruska, RE; Skattebøl, A; Triggle, DJ | 1 |
| Beam, KG; Knudson, CM | 1 |
| Massieu, L; Tapia, R | 1 |
| Dunn, SM | 1 |
| Bergamaschi, S; Cominetti, P; Govoni, S; Parenti, M; Trabucchi, M | 1 |
| Bihoreau, C; Clauser, H; Drouva, SV; Kordon, C; Laplante, E; Rasolonjanahary, R; Rerat, E | 1 |
| Catt, KJ; Hausdorff, WP | 1 |
| Bogónez, E; Martínez-Serrano, A; Satrústegui, J; Vitórica, J | 1 |
| Froehner, SC | 1 |
| Boyd, RA; Giacomini, JC; Giacomini, KM | 1 |
| Dunér-Engström, M; Fredholm, BB | 1 |
| Lacerda, AE; Poder, TC; Silberberg, SD | 1 |
| Bean, B | 2 |
| Brown, AM; Skattebøl, A; Triggle, DJ | 1 |
| Anderson, EG; Scroggs, RS | 1 |
| Birnbaumer, L; Brown, AM; Codina, J; Imoto, Y; Mattera, R; Yatani, A | 1 |
| Olsen, R; Powis, G; Seewald, M | 1 |
| Imoto, K; Mikami, A; Mori, Y; Narumiya, S; Niidome, T; Numa, S; Takeshima, H; Tanabe, T | 1 |
| Birnbaumer, L; Brown, AM; Campbell, KP; Horne, W; Kim, HS; Lacerda, AE; Perez-Reyes, E; Rampe, D; Wei, XY | 1 |
| Al-Dahan, MI; Thalmann, RH | 1 |
| Aaronson, PI; Bolton, TB; Lang, RJ; MacKenzie, I | 1 |
| Jones, SW; Marks, TN | 1 |
| Collins, F; Lile, JD | 1 |
| Caffrey, JM; Farach-Carson, MC | 1 |
| Ashcroft, FM; Rorsman, P; Smith, PA | 1 |
| Castillo, CJ; Fonteríz, RI; García, AG; López, MG; Rosenheck, K | 1 |
| Eriksson, H; Heilbronn, E | 1 |
| Watkins, WD; Whorton, AR; Xuan, YT | 1 |
| Höltje, HD | 1 |
| Catterall, WA; Nunoki, K; Seagar, MJ; Takahashi, M | 1 |
| Burgess, AJ; Harrison, TM; Norman, RI | 1 |
| Fosset, M; Kazazoglou, T; Lazdunski, M; Renaud, JF; Schmid, A | 1 |
| Ohya, Y; Sperelakis, N | 1 |
| Wibo, M | 1 |
| Aizawa, T; Komatsu, M; Nagasawa, Y; Takeda, T; Yamada, T; Yokokawa, N | 1 |
| Hirata, H | 1 |
| McDonald, T; Pelzer, D; Trautwein, W | 1 |
| Brush, K; Chang, RJ; Cook, R; Hamilton, SL; Hawkes, MJ; Smilowitz, HM | 1 |
| Alvarez, RM; Brush, KL; Fill, M; Hamilton, SL; Hawkes, MJ; Schilling, WP; Stefani, E | 1 |
| Lemos, JR; Nowycky, MC | 1 |
| Hess, P; Logothetis, DE; Plummer, MR | 1 |
| Akiyama, S; Cornwell, MM; Kikuchi, J; Kiue, A; Kohno, K; Kuwano, M; Nogae, I; Pastan, I; Suzuki, K; Yoshida, Y | 1 |
| Carbone, E; Swandulla, D | 1 |
| Goldin, SM; Turner, TJ | 1 |
| Freedman, SB; Kongsamut, S; Miller, RJ | 1 |
| Aragonés, MD; Catalán, RE; Encabo, P; Hernández, F; Martínez, AM | 1 |
| Barker, JL; Meyers, DE | 1 |
| Dillon, JS; Gu, XH; Nayler, WG | 1 |
| Amoroso, S; Annunziato, L; Canzoniero, LM; Di Renzo, GF; Fatatis, A; Taglialatela, M | 1 |
| Kanngiesser, U; Nalik, P; Pongs, O | 1 |
| Brown, AM; Caffrey, JM; Rampe, D; Schneider, MD | 1 |
| Bode-Greuel, KM; Singer, W | 1 |
| Coburn, RA; Solo, AJ; Suto, MJ; Triggle, AM; Triggle, DJ; Wierzba, M | 1 |
| Hosey, MM; O'Callahan, CM | 1 |
| Soldatov, NM | 1 |
| Florio, T; Grimaldi, M; Landolfi, E; Magri, G; Meucci, O; Schettini, G | 1 |
| Hanbauer, I; Sanna, E | 1 |
| Brisac, AM; Champeroux, P; Laurent, S; Schmitt, H | 1 |
| Kostiuk, PG; Rozhmanova, OM; Soldatov, NM; Stel'makh, LN; Voronina, SG | 1 |
| Benham, CD; Tsien, RW | 1 |
| Bolger, GT; Rafferty, MF; Skolnick, P | 1 |
| Quirion, R | 1 |
| Fujiwara, T; Noguchi, H; Tokuma, Y | 1 |
| Arrowsmith, JE; Blackburn, KJ; Burges, RA; Campbell, SF; Cross, PE; Gardiner, DG; Stubbs, JK | 1 |
| Gerard, P; Huchet, AM; Huguet, F; Narcisse, G | 1 |
| Burnett, JC; Ritter, SG; Strong, CG; Zachariah, PK | 1 |
| Barhanin, J; Henning, R; Lazdunski, M; Lerch, U; Oekonomopulos, R; Qar, J; Romey, G; Urbach, H | 1 |
| Schilling, WP | 1 |
| Chhabra, A; Fairhurst, AS; Thayer, SA; Welcome, M | 1 |
| Glossmann, H; Striessnig, J; Zernig, G | 1 |
| Herbette, LG; Rhodes, DG; Sarmiento, JG | 1 |
| Dubur, GJ; Gendvilienè, VI; Kimenis, AA; Macianskiene, RA; Narusevicius, EV; Selga, MJ; Simkhovich, BZ; Velena, AH; Vitolina, RO; Zarinsh, GV | 1 |
| Brandt, NR; Caswell, AH; Kawamoto, RM | 2 |
| Barhanin, J; Borsotto, M; Fosset, M; Lazdunski, M | 1 |
| Ford, RM; Lal, S; Nair, NP; Olivier, A; Quirion, R; Stratford, JG | 1 |
| Bassett, A; Brandt, N | 1 |
| Barrett, JE; Bolger, GT; Lueddens, H; Paul, SM; Skolnick, P; Weissman, BA; Witkin, J | 1 |
| Campbell, KP; Kahl, SD; Sharp, A; Strom, M | 1 |
| Snyder, SH | 1 |
| Bäärnhielm, C; Hansson, G | 1 |
| Reynolds, IJ; Snowman, AM; Snyder, SH | 1 |
| Chambers, JP; Dungan, J; Rael, ED; Valdes, JJ; Wayner, MJ | 1 |
| Fairhurst, AS; Minaskanian, G; Pham, DH; Schultz, CM; Thayer, SA | 1 |
| Miller, RJ; Murphy, SN; Shangold, GA | 1 |
| Adelstein, RS; Ambudkar, IS; Movsesian, MA; Shamoo, AE | 1 |
| Bowling, N; Conery, BG; Hayes, JS; Kauffman, RF | 1 |
| You, KS | 1 |
| Cillero, FJ; Fau de Casa-Juana, M; Ortega, MP; Priego, JG; Sunkel, CE | 1 |
| Barlier, S; Colin, DA; Couraud, F; Dayanithi, G; Kretz-Zaepfel, M; Martin-Moutot, N; Nordmann, JJ | 1 |
| Cimiraglia, R; Hofmann, HJ | 1 |
| Böcker, RH; Guengerich, FP | 1 |
| Glossmann, H; Zernig, G | 1 |
| Bodor, N; Raghavan, KS; Shek, E | 1 |
| Dagnino, L; Knaus, EE; Li-Kwong-Ken, MC; Wolowyk, MW; Wynn, H | 1 |
| Boerth, LW; Kazanjian, PH; Kemmerich, B; Marsh, JD; Pennington, JE | 1 |
| Bäärnhielm, C; Westerlund, C | 1 |
| Bolger, GT; Crawley, JN; Paul, SM; Rafferty, MF; Skolnick, P | 1 |
| Gjörstrup, P; Hårding, H; Isaksson, R; Westerlund, C | 1 |
| De Matteis, F; Gibbs, AH | 1 |
| Giacomini, JC; Giacomini, KM; Nelson, WL; Zobrist, RH | 1 |
| Marangos, PJ; Verma, A | 1 |
| Battaglia, M; Diglio, CA; Honn, KV; Neagos, G; Onoda, JM; Pampalona, K; Sloane, BF; Taylor, JD | 1 |
| Balicki, R; Fiszer-Maliszewska, L; Kaczmarek, L; Mordarski, M; Nantka-Namirski, P; Wieczorek, J | 1 |
| Aizawa, M; Kawamatsu, Y; Meguro, K; Nagaoka, A; Sohda, T | 1 |
| Janis, RA; Triggle, DJ | 1 |
| Cavero, I; Spedding, M | 1 |
| Kass, RS; Sanguinetti, MC | 1 |
| Jones, H; Khandwala, A; Van Inwegen, RG; Weinryb, I | 1 |
| Ferry, DR; Gadow, C; Glossmann, H; Goll, A | 1 |
| Kostiuk, PG | 1 |
| Triggle, DJ | 2 |
| Ferry, DR; Glossmann, H; Goll, A; Rombusch, M | 1 |
| Hildebrandt, J; Lauschke, G; Schmidt, J; Sinkwitz, KD | 1 |
| Hondeghem, LM; Katzung, BG | 1 |
| Bolger, G; Fraser, CM; Jung, CY; Schaber, JS; Triggle, DJ; Venter, JC | 1 |
| Ferry, DR; Glossmann, H; Linn, T; Rombusch, M | 1 |
| Freedman, SB; Miller, RJ | 1 |
| Diumaev, KM; Smirnov, LD | 1 |
| Altura, BM; Altura, BT | 1 |
| Luu, MD; Martin, JV; Mendelson, WB; Paul, SM; Skolnic, P; Wagner, R | 1 |
| Bodor, N; Farag, HH | 1 |
| Liu, J; Rutledge, A; Triggle, DJ | 1 |
| Sze, PY; Yu, BH | 1 |
| Canda, A; Sze, PY; Yu, BH | 1 |
| Gizinski, MJ; Schumaker, KS | 3 |
| de Boland, AR; Vazquez, G | 1 |
| Bagó, A; Deák, F; Hunyady, L; Rohács, T; Spät, A | 1 |
| Gomis, A; Gutierrez, LM; Reig, JA; Sala, F; Viniegra, S | 1 |
| Campbell, KP; De Waard, M; Mori, Y; Pragnell, M; Snutch, TP; Tanabe, T | 1 |
| Dockrell, ME; Haynes, WG; Olverman, HJ; Waugh, CJ; Webb, DJ; Williams, BC | 1 |
| Gøtzsche, LS; Pedersen, EM | 1 |
| Mizusawa, H; Omote, M | 1 |
| Hettrick, DA; Pagel, PS; Warltier, DC | 1 |
| Browaeys-Poly, E; Guilbault, P; Ouadid, H; Vilain, JP | 1 |
| Albillos, A; Artalejo, AR; Carbone, E; Gandía, L; García, AG; López, MG | 1 |
| Croxton, TL; Farley, LS; Hirshman, CA; Vannier, C | 1 |
| Berger, AJ; Umemiya, M | 1 |
| Miras-Portugal, MT; Rodriguez-Pascual, F; Torres, M | 1 |
| Beam, KG; Dirksen, RT | 1 |
| Burnett, JC; Canzanello, VJ; Gores, G; Hay, E; Krom, R; Porayko, M; Romero, JC; Taler, SJ; Textor, SC; Wiesner, R | 1 |
| Berrow, N; Brickley, K; Campbell, V; Dolphin, AC; Page, K; Wade, R | 1 |
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| Liu, L; Qian, Y; Song, Y; Wang, Z; Zhang, H; Zhang, S | 1 |
| Babu, R; Božić, N; Djokic, L; Jeremic, S; Lončar, N; Nikodinovic-Runic, J; Opsenica, IM; Senthamaraikannan, R; Simić, S; Vujčić, Z | 1 |
| Bajpai, A; Mishra, AP; Rai, AK | 1 |
| Asgharnasl, S; Eivazzadeh-Keihan, R; Maleki, A; Radinekiyan, F | 1 |
| Jiang, X; Malone, DC; Manini, TM; Pepine, C; Solberg, LM; Vouri, SM; Winterstein, AG | 1 |
| Bloch, SC; Chumber, NM; Farrow, MA; King, M; Lacy, DB; Moton-Melancon, K; Shupe, J; Spiller, BW; Washington, MK | 1 |
| Akhtar, S; Ghosh, R; Kumar Mandal, T; Maiti, P; Manna, D; Mondal, S | 1 |
| Bonet, A; Borges, F; Daniel, S; Ismaili, L; Jóźwiak, K; Maj, M; Marco-Contelles, J; Martin, H; Pachòn Angona, I; Refouvelet, B; Silva, TB; Wnorowski, A | 1 |
| Lamberth, C | 1 |
| Bisenieks, E; Bruvere, I; Domracheva, I; Duburs, G; Kanepe-Lapsa, I; Turovska, B; Velena, A; Vilskersts, R | 1 |
| Ferreira, RJ; Hadizadeh, F; Mollazadeh, S | 1 |
| He, L; Liu, R; Lu, Z; Ma, S; Sun, X; Yu, Q | 1 |
| Esterhuizen, TM; Mugendi, GA; Mutua, FM; Natale, P; Strippoli, GF | 1 |
| Auria-Luna, F; Fernández-Moreira, V; Gimeno, MC; Herrera, RP; Marqués-López, E; Marzo, I; Romanos, E | 1 |
| Anaikutti, P; Makam, P | 1 |
| Gao, S; Yan, N | 1 |
| Cai, Y; Cao, S; Du, Y; Hou, YN; Huang, K; Lee, CS; Lee, HC; Li, WH; Wang, QW; Wang, S; Xie, XJ; Zhang, H; Zhao, YJ; Zhao, ZY; Zhu, WJ | 1 |
| Kumar, L; Sai Chebrolu, T; Verma, R | 1 |
| El-Bastawissy, E; El-Moselhy, TF; Salama, AA; Sidhom, PA | 1 |
| Bisenieks, E; Dišlere, K; Duburs, G; Paramonova, N; Rostoka, E; Sjakste, N | 1 |
| Hu, C; Huang, C; Jiang, Z; Li, Y; Wu, Q; Yang, C; Zhen, S | 1 |
| Du, J; Li, R; Li, Y; Lv, J; Qi, S; Shan, Y; Xue, L; Yang, Q | 1 |
| Li, Y; Sun, D; Wu, L; Xu, H; Xue, L; Yang, Q; Zhang, H | 1 |
| Karthick, R; Karthikeyan, S; Pachamuthu, MP; Velraj, G | 1 |
| Abdelmajed, MA; Attia, TZ; El-Din, KMB; Omar, MA | 1 |
| Azumaya, I; Isomura, S; Okayasu, M; Okuno, Y; Sato, Y; Suzuki, A; Watanabe, M | 1 |
| Zhang, JY; Zhu, XQ | 1 |
| Abourehab, MAS; Belal, A; El-Hamamsy, MH; El-Moselhy, TF; Mehany, ABM; S El-Din, N; Saad, MH; Tawfik, HO | 1 |
| Elso, O; Liñares, GG; Sülsen, V | 1 |
| Acosta-García, LM; Alvarez de la Rosa, D; Aranda, MT; González-Muñiz, R; Martín-Martínez, M; Passeri, D; Pellicciari, R; Pérez de Vega, MJ; Pérez-Gordillo, FL; Serrano-Morillas, N | 1 |
| Bakr, EA; El-Kemary, M; El-Nahass, MN; Fayed, TA; Hamada, WM; Noser, AA; Salem, MM | 1 |
83 review(s) available for 1,4-dihydropyridine and dihydropyridines
| Article | Year |
|---|---|
Calcium channels expressed in vascular smooth muscle.
Topics: Amino Acid Sequence; Angiotensin II; Calcium; Calcium Channels; Cell Membrane; Dihydropyridines; DNA; Gene Expression; Gene Expression Regulation; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Fluid; Muscle Contraction; Muscle, Smooth, Vascular; Receptors, Cell Surface; Receptors, Cholinergic; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Ryanodine Receptor Calcium Release Channel | 1992 |
Muscarinic regulation of membrane ion channels in airway smooth muscle cells.
Topics: Animals; Dihydropyridines; Guanosine Triphosphate; Humans; Ion Channels; Membrane Potentials; Methacholine Chloride; Muscle, Smooth; Parasympathomimetics; Respiratory System | 1992 |
The role of neuronal calcium channels in dependence on ethanol and other sedatives/hypnotics.
Topics: Alcoholism; Animals; Barbiturates; Benzodiazepines; Binding Sites; Calcium Channels; Dihydropyridines; Ethanol; Humans; Narcotics; Neurons | 1991 |
Ca2+ channels and excitation-contraction coupling.
Topics: Action Potentials; Animals; Caffeine; Calcium; Calcium Channels; CHO Cells; Cricetinae; Dihydropyridines; Genes; Humans; Malignant Hyperthermia; Mammals; Mice; Mice, Mutant Strains; Muscle Contraction; Muscle Proteins; Muscular Diseases; Myocardial Contraction; Organ Specificity; Protein Engineering; Receptors, Nicotinic; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Signal Transduction | 1991 |
Mechanisms that may underlie the behavioural effects of ethanol.
Topics: Alcoholic Intoxication; Animals; Aspartic Acid; Behavior; Behavior, Animal; Calcium; Calcium Channels; Cell Membrane; Dihydropyridines; Drug Tolerance; Ethanol; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Ion Channel Gating; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Synaptic Transmission | 1991 |
[Structure and function of the receptor for calcium channel blockers from skeletal muscle].
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium Channels; Cloning, Molecular; Dihydropyridines; DNA; Membrane Potentials; Molecular Sequence Data; Muscle Contraction; Muscles; Receptors, Nicotinic; RNA | 1990 |
Properties and regulation of calcium channels in muscle cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Cloning, Molecular; Dihydropyridines; Humans; Magnesium; Muscles; Permeability | 1990 |
Toward an understanding of the dihydropyridine-sensitive calcium channel.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calcium Channels; Dihydropyridines; Membrane Proteins; Molecular Sequence Data; Muscle, Smooth; Muscles; Terminology as Topic | 1990 |
Modulation of calcium channel function by drugs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Electric Conductivity; Heart Rate; Homeostasis; Humans; Ion Channels; Membrane Potentials; Nifedipine; Pyridines; Receptors, Cell Surface; Structure-Activity Relationship | 1985 |
Calcium channels and calcium channel drugs: recent biochemical and biophysical findings.
Topics: Adenosine; Affinity Labels; Animals; Autoradiography; Buffers; Calcium Channel Blockers; Dihydropyridines; Erythrocyte Membrane; Humans; Indicators and Reagents; Ion Channels; Photochemistry; Pyridines | 1985 |
Adenosine receptors and calcium: basis for proposing a third (A3) adenosine receptor.
Topics: Adenosine; Adenylyl Cyclases; Animals; Binding, Competitive; Calcium; Cyclic AMP; Dihydropyridines; Evoked Potentials; Heart; Ion Channels; Muscles; Neuromuscular Junction; Neurons; Neurotransmitter Agents; Potassium; Pyridines; Receptors, Cell Surface; Receptors, Purinergic; Sodium; Synaptic Transmission | 1986 |
Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic beta-Agonists; Animals; Calcium; Dihydropyridines; In Vitro Techniques; Ion Channels; Isoproterenol; Kinetics; Models, Biological; Nifedipine; Phosphorylation; Pyridines; Receptors, Adrenergic, beta | 1986 |
Differential sensitivity of calcium channels to dihydropyridines. The modulated receptor hypothesis.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Humans; Ion Channels; Pyridines; Receptors, Nicotinic | 1986 |
Comparative pharmacology of 1,4-dihydropyridines and other Ca2+ channel ligands.
Topics: Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Humans; Ion Channels; Pyridines | 1987 |
Molecular properties of dihydropyridine-sensitive calcium channels in skeletal muscle.
Topics: Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Ion Channels; Muscles | 1988 |
Calcium currents in embryonic and neonatal mammalian skeletal muscle.
Topics: Animals; Animals, Newborn; Barium; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Electrophysiology; Embryo, Mammalian; Embryo, Nonmammalian; Ion Channels; Isradipine; Muscles; Oxadiazoles; Stereoisomerism | 1988 |
New insights into the molecular structure of the dihydropyridine-sensitive calcium channel.
Topics: Animals; Calcium Channels; Dihydropyridines; Muscles; Protein Conformation | 1988 |
More than a Ca2+ channel?
Topics: Animals; Calcium Channels; Dihydropyridines; Receptors, Nicotinic | 1989 |
Direct G-protein regulation of Ca2+ channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channels; Cattle; Dihydropyridines; Electric Conductivity; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Humans; Isoproterenol; Thionucleotides | 1989 |
Molecular properties of dihydropyridine-sensitive calcium channels.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Glycosylation; Immunosorbent Techniques; Macromolecular Substances; Muscles; Receptors, Nicotinic | 1989 |
Monoclonal antibodies against calcium channels.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Antigens; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Glycosylation; Macromolecular Substances; Rabbits | 1989 |
Appearance and function of voltage-dependent Ca2+ channels during pre- and postnatal development of cardiac and skeletal muscles.
Topics: Animals; Calcium Channels; Chick Embryo; Cyclic AMP; Denervation; Dihydropyridines; Heart; Isoproterenol; Muscle Development; Muscles | 1989 |
Mode of action of calcium antagonists: voltage-dependence and kinetics of drug-receptor interaction.
Topics: Animals; Aorta; Arteries; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; Kinetics; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Potassium; Rats; Receptors, Nicotinic | 1989 |
Neuronal calcium channels: kinetics, blockade and modulation.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cations; Dihydropyridines; GTP-Binding Proteins; Humans; Ion Channel Gating; Kinetics; Ligands; Neurons; Neurotoxins; Neurotransmitter Agents; Signal Transduction | 1989 |
Neuronal receptors.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Calcium Channels; Dihydropyridines; Guanine Nucleotides; Isoenzymes; Ligands; Monoamine Oxidase; Nervous System; Peptides; Pyridines; Rabbits; Radioligand Assay; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Receptors, Nicotinic; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Sodium | 1986 |
Stereospecificity for nicotinamide nucleotides in enzymatic and chemical hydride transfer reactions.
Topics: Adenosine Monophosphate; Catalysis; Coenzymes; Crystallography; Dihydropyridines; Fluorescence; Glycosides; Hydrogen; Magnetic Resonance Spectroscopy; Molecular Conformation; NAD; NADP; Niacinamide; Nucleotides; Oxidation-Reduction; Protein Binding; Pyridines; Substrate Specificity; Terminology as Topic | 1985 |
The 1,4-dihydropyridine receptor: a regulatory component of the Ca2+ channel.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Chemical Phenomena; Chemistry; Dihydropyridines; Humans; Ion Channels; Muscle, Smooth; Organ Specificity; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship | 1984 |
"Calcium antagonists": a class of drugs with a bright future. Part II. Determination of basic pharmacological properties.
Topics: Animals; Barium; Calcium; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Electrophysiology; Heart Rate; Ion Channels; Lanthanum; Methods; Muscle, Smooth; Myocardial Contraction; Nifedipine; Potassium; Pyridines; Receptors, Adrenergic, alpha; Stereoisomerism; Verapamil | 1984 |
[Calcium ion channels in the cell membrane].
Topics: Animals; Brachyura; Calcium; Cations, Divalent; Cations, Monovalent; Cattle; Decapodiformes; Dihydropyridines; Fluorides; In Vitro Techniques; Ion Channels; Kinetics; Membrane Potentials; Mice; Mollusca; Neurons; Organ Specificity; Pyridines; Rats; Species Specificity; Verapamil | 1984 |
Antiarrhythmic agents: the modulated receptor mechanism of action of sodium and calcium channel-blocking drugs.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Biotransformation; Calcium Channel Blockers; Cardiac Complexes, Premature; Dihydropyridines; Drug Interactions; Electrophysiology; Humans; Hydrogen-Ion Concentration; Ion Channels; Pyridines; Receptors, Drug; Sodium; Structure-Activity Relationship; Tachycardia | 1984 |
Are dihydropyridine binding sites voltage sensitive calcium channels?
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Dihydropyridines; Ion Channels; Muscle, Smooth; Muscles; Myocardium; Neurons; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Pyridines | 1984 |
[Current trends in the search for membrane-active compounds and membrane-active compound-based drugs].
Topics: Antioxidants; Antiviral Agents; Cardiovascular Agents; Cell Membrane Permeability; Dihydropyridines; Flavonoids; Pharmacology; Phenols; Polymers; Polyphenols; Psychotropic Drugs; Pyridines; Pyrimidines; Research; Vitamin E | 1984 |
Microcirculatory actions and uses of naturally-occurring (magnesium) and novel synthetic calcium channel blockers.
Topics: Anesthesia; Animals; Arterioles; Blood Pressure; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cerebrovascular Circulation; Cerebrovascular Disorders; Coronary Disease; Diabetes Mellitus; Dihydropyridines; Female; Humans; Hypertension; Ketamine; Magnesium; Magnesium Deficiency; Microcirculation; Muscle, Smooth, Vascular; Muscles; Nifedipine; Nisoldipine; Nitrendipine; Nutritional Requirements; Pentobarbital; Pre-Eclampsia; Pregnancy; Pyridines; Rats; Vasoconstrictor Agents; Vasodilator Agents; Venules | 1984 |
Nifedipine. Dose-related increase in mortality in patients with coronary heart disease.
Topics: Angina Pectoris; Arrhythmias, Cardiac; Calcium Channel Blockers; Confidence Intervals; Coronary Disease; Depression, Chemical; Dihydropyridines; Dose-Response Relationship, Drug; Hemorrhage; Humans; Hypotension; Myocardial Contraction; Myocardial Ischemia; Nifedipine; Odds Ratio; Renin-Angiotensin System; Sympathetic Nervous System; Time Factors | 1995 |
Membrane interaction of calcium channel antagonists modulated by cholesterol. Implications for drug activity.
Topics: Animals; Biological Availability; Calcium Channel Blockers; Calcium Channels; Cardiovascular System; Cell Membrane; Cholesterol; Dihydropyridines; Humans; Lipid Bilayers; Models, Molecular; Phosphatidylcholines; Receptors, Drug | 1993 |
Short acting dihydropyridine (vasodilating) calcium channel blockers for hypertension: is there a risk?
Topics: Calcium Channel Blockers; Case-Control Studies; Clinical Trials as Topic; Dihydropyridines; Humans; Hypertension; Myocardial Ischemia; Nifedipine; Sensitivity and Specificity | 1996 |
Clinical relevance of 24 h blood pressure control by 1,4-dihydropyridines.
Topics: Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Coronary Disease; Dihydropyridines; Humans | 1996 |
Identification of binding sites for calcium channel antagonists.
Topics: Affinity Labels; Benzazepines; Binding Sites; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Drug Interactions; Humans; Muscle, Skeletal; Thiazepines; Verapamil | 1996 |
Dihydropyridine calcium antagonists: beneficial or adverse effects in the setting of myocardial ischaemia/reperfusion?
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Vessels; Dihydropyridines; Dogs; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardial Stunning; Nisoldipine; Vasoconstriction | 1997 |
Complementary actions and risk reduction: the rationale for combination of an angiotensin converting enzyme inhibitor with a non-dihydropyridine calcium antagonist.
Topics: Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Clinical Trials as Topic; Dihydropyridines; Drug Therapy, Combination; Humans; Hypertension | 1997 |
Contributions of electron microscopy and single-particle techniques to the determination of the ryanodine receptor three-dimensional structure.
Topics: Animals; Calmodulin; Calsequestrin; Carrier Proteins; Dihydropyridines; DNA-Binding Proteins; Heat-Shock Proteins; Image Processing, Computer-Assisted; Microscopy, Electron; Models, Molecular; Muscle Proteins; Muscle, Skeletal; Protein Binding; Protein Conformation; Ryanodine Receptor Calcium Release Channel; Tacrolimus; Tacrolimus Binding Proteins | 1998 |
Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Dogs; Guinea Pigs; Hypertension; Nifedipine; Rats; Rats, Inbred SHR; Structure-Activity Relationship | 1998 |
Dihydropyridine calcium-channel blockers for the treatment of hypertensive diabetic patients.
Topics: Amlodipine; Calcium Channel Blockers; Diabetic Angiopathies; Dihydropyridines; Enalapril; Fosinopril; Humans; Hypertension; Randomized Controlled Trials as Topic | 2000 |
Pharmacologic management of atrial fibrillation: current therapeutic strategies.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Atrial Fibrillation; Calcium Channel Blockers; Chronic Disease; Digoxin; Dihydropyridines; Drug Administration Routes; Electrocardiography; Embolism; Heart Rate; Humans; Practice Guidelines as Topic; Prognosis; Propranolol; Secondary Prevention; Tachycardia, Paroxysmal; Verapamil | 2001 |
Pranidipine, a 1,4-dihydropyridine calcium channel blocker that enhances nitric oxide-induced vascular relaxation.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Cyclic GMP; Dihydropyridines; Drug Synergism; Endothelium, Vascular; Humans; Muscle, Smooth, Vascular; Myocardial Contraction; Nitric Oxide; Vasodilation; Vasodilator Agents | 2001 |
Treatment advances for cocaine-induced ischemic stroke: focus on dihydropyridine-class calcium channel antagonists.
Topics: Brain Ischemia; Calcium Channel Blockers; Cocaine-Related Disorders; Dihydropyridines; Humans; Isradipine; Stroke; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Vasospasm, Intracranial | 2001 |
[Calcium channel blockers in the treatment of cardiovascular disease].
Topics: Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Humans | 2001 |
Laragh's lessons in pathophysiology and clinical pearls for treating hypertension.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Calcium Channel Blockers; Cardiology; Dihydropyridines; Drug Therapy, Combination; Education, Medical, Continuing; Heart Diseases; Humans; Hypertension; Nitroprusside; Renin; Renin-Angiotensin System; Vasoconstriction | 2001 |
Angiotensin converting enzyme inhibition and dihydropyridine calcium channel blockade in the treatment of left ventricular hypertrophy in arterial hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Diuretics; Drug Therapy, Combination; Enalapril; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Meta-Analysis as Topic; Nifedipine; Prognosis; Prospective Studies; Randomized Controlled Trials as Topic; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Sodium Chloride Symporter Inhibitors; Time Factors; Ventricular Dysfunction, Left | 2002 |
Pharmacogenetics of cytotoxic drugs.
Topics: Antineoplastic Agents; Arylamine N-Acetyltransferase; Cytochrome P-450 Enzyme System; Cytotoxins; Dihydropyridines; Glucuronosyltransferase; Humans; Methyltransferases; Neoplasms; Oxidoreductases; Pharmacogenetics; Polymorphism, Genetic | 2001 |
[Innovative molecular transformation using optically active alpha-amino acids].
Topics: Acetals; Amines; Amino Acids; Aminobutyrates; Catalysis; Chemistry, Organic; Dihydropyridines; Imines; Ketones; Molecular Conformation; Organic Chemistry Phenomena; Proline; Silanes; Stereoisomerism | 2002 |
Atheroprotective effects of long-acting dihydropyridine-type calcium channel blockers: evidence from clinical trials and basic scientific research.
Topics: Arteriosclerosis; Calcium Channel Blockers; Delayed-Action Preparations; Dihydropyridines; Humans; In Vitro Techniques; Models, Cardiovascular; Randomized Controlled Trials as Topic; Time Factors | 2003 |
1,4-Dihydropyridines as calcium channel ligands and privileged structures.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cardiovascular System; Cell Membrane; Dihydropyridines; Humans; Ligands; Molecular Conformation; Molecular Structure; Receptors, Cell Surface | 2003 |
Dihydropyridine calcium channel blockers: basic pharmacological similarities but fundamental therapeutic differences.
Topics: Calcium Channel Blockers; Dihydropyridines; Humans; Hypertension | 2004 |
Drug treatment of essential hypertension: the case for initial combination therapy.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Cardiovascular Diseases; Dihydropyridines; Diuretics; Drug Therapy, Combination; Humans; Hypertension; Middle Aged; Renin-Angiotensin System; Sodium | 2004 |
Fused 1,4-dihydropyridines as potential calcium modulatory compounds.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Humans; Ion Channel Gating; Models, Molecular | 2006 |
Cancer cell permeability-glycoprotein as a target of MDR reverters: possible role of novel dihydropyridine derivatives.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Dihydropyridines; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasms; Permeability | 2006 |
Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Dihydropyridines; Dioxanes; Humans; Piperazines; Quinazolines; Receptors, Adrenergic, alpha-1; Structure-Activity Relationship; Substrate Specificity | 2007 |
Are differences in calcium antagonists relevant across all stages of nephropathy or only proteinuric nephropathy?
Topics: Albuminuria; Angiotensins; Animals; Antihypertensive Agents; Blood Pressure; Calcium; Calcium Channel Blockers; Clinical Trials as Topic; Dihydropyridines; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Proteinuria | 2007 |
[Hypertension as a source of cognitive regression, or dementia].
Topics: Aged; Aging; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cognition; Dementia; Dihydropyridines; Humans; Hypertension | 2007 |
Effective management of hypertension with dihydropyridine calcium channel blocker-based combination therapy in patients at high cardiovascular risk.
Topics: Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Hypertension; Practice Guidelines as Topic | 2008 |
Natural and synthetic antioxidants: an updated overview.
Topics: Animals; Antioxidants; Carbolines; Dihydropyridines; Humans; Oxidative Stress; Plant Preparations; Selenium Compounds; Tea; Tocopherols | 2010 |
Use of dihydropyridine calcium channel blockers in the management of hypertension in Eastern Asians: a scientific statement from the Asian Pacific Heart Association.
Topics: Asia, Eastern; Calcium Channel Blockers; Dihydropyridines; Humans; Hypertension; Randomized Controlled Trials as Topic; Societies, Medical; Treatment Outcome | 2011 |
Reciprocal dihydropyridine and ryanodine receptor interactions in skeletal muscle activation.
Topics: Animals; Calcium; Dihydropyridines; Humans; Muscle, Skeletal; Ryanodine Receptor Calcium Release Channel | 2011 |
1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 1): action in ion channels and GPCRs.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Chemistry, Pharmaceutical; Dihydropyridines; Humans; Ion Channels; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2011 |
[Derivatives of 1,4-dihydropyridines as "priviledged structures" and their pharmacological potential].
Topics: Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Humans; Hypertension; Structure-Activity Relationship | 2011 |
1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 2): action in other targets and antitargets.
Topics: Alzheimer Disease; Animals; Antitubercular Agents; Atherosclerosis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydropyridines; Drug Resistance, Multiple; Humans; Platelet Activating Factor; Tuberculosis | 2012 |
Stabilizers of neuronal and mitochondrial calcium cycling as a strategy for developing a medicine for Alzheimer's disease.
Topics: Alzheimer Disease; Apoptosis; Calcineurin; Calcium; Calcium Channels; Calpain; Dihydropyridines; Free Radicals; Humans; Mitochondria; Neurons; Polyphenols; Sodium | 2012 |
Efficacy and safety of dual calcium channel blockade for the treatment of hypertension: a meta-analysis.
Topics: Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Randomized Controlled Trials as Topic; Treatment Outcome | 2013 |
Pharmacoperones and the calcium sensing receptor: exogenous and endogenous regulators.
Topics: Allosteric Regulation; Animals; Calcium; Dihydropyridines; Drug Discovery; Gene Expression Regulation; Glutathione; Humans; Mutation; Protein Biosynthesis; Protein Folding; Protein Transport; Receptors, Calcium-Sensing | 2014 |
4-isoxazolyl-1,4-dihydropyridines: a tale of two scaffolds.
Topics: ATP Binding Cassette Transporter, Subfamily B; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Humans; Isoxazoles; Molecular Conformation; Structure-Activity Relationship | 2014 |
[24-hour perfect BP-lowering therapy using long-acting dihydropyridine calcium channel blockers].
Topics: Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Circadian Rhythm; Dihydropyridines; Humans; Hypertension | 2014 |
Collaborating with Alexander Scriabine and the Miles Institute for Preclinical Pharmacology.
Topics: Academies and Institutes; Animals; Arachidonic Acids; Brain; Calcium Channels; Cooperative Behavior; Dihydropyridines; Drug Discovery; Endocannabinoids; History, 20th Century; History, 21st Century; Humans; Ligands; Polyunsaturated Alkamides; Potassium Channels; Research; United States | 2015 |
1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues-Model Compounds Targeting Oxidative Stress.
Topics: Amlodipine; Animals; Antioxidants; Azetidinecarboxylic Acid; Calcium Channel Blockers; Cattle; Dihydropyridines; Epithelial Cells; Humans; Hydrogen; Lipoproteins, LDL; Mice; Microsomes; Mitochondria; Niacinamide; Nifedipine; Nitrobenzenes; Oxidants; Oxidative Stress; Piperazines | 2016 |
Atypical 1,4-dihydropyridine derivatives, an approach to neuroprotection and memory enhancement.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Humans; Memory; Nervous System Diseases; Neuroprotection; Neurotransmitter Agents | 2016 |
Molecular Mechanism of Dihydropyridine Ca
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Dihydropyridines; Disease Models, Animal; Disease Progression; Humans; Hypertension, Pulmonary; Molecular Targeted Therapy; Muscle, Smooth, Vascular; Nicardipine; Pulmonary Artery; Rats; Receptors, Calcium-Sensing; Up-Regulation; Vascular Remodeling; Vasoconstriction | 2016 |
How to Improve Effectiveness and Adherence to Antihypertensive Drug Therapy: Central Role of Dihydropyridinic Calcium Channel Blockers in Hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Essential Hypertension; Humans; Medication Adherence; Nifedipine; Risk Factors; Treatment Outcome; Vasodilator Agents | 2018 |
Calcium channel blockers for primary and secondary Raynaud's phenomenon.
Topics: Calcium Channel Blockers; Dihydropyridines; Humans; Nifedipine; Pain Management; Placebos; Publication Bias; Randomized Controlled Trials as Topic; Raynaud Disease; Severity of Illness Index | 2017 |
Effects of Long- and Intermediate-Acting Dihydropyridine Calcium Channel Blockers in Hypertension: A Systematic Review and Meta-Analysis of 18 Prospective, Randomized, Actively Controlled Trials.
Topics: Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Randomized Controlled Trials as Topic; Treatment Outcome | 2018 |
1,4-Dihydropyridine: A Dependable Heterocyclic Ring with the Promising and the Most Anticipable Therapeutic Effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antihypertensive Agents; Antineoplastic Agents; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Heterocyclic Compounds; Neoplasms; Ulcer | 2019 |
Multicomponent reactions in crop protection chemistry.
Topics: Agrochemicals; Alternaria; Animals; Antifungal Agents; Crop Protection; Dihydropyridines; Helminthosporium; Insecticides; Molecular Structure; Spodoptera | 2020 |
Calcium channel blockers for people with chronic kidney disease requiring dialysis.
Topics: Adult; Antihypertensive Agents; Bias; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Humans; Hypertension; Hypotension; Randomized Controlled Trials as Topic; Renal Dialysis; Renal Insufficiency, Chronic | 2020 |
Current Status on 1,4-Dihydropyridine Derivatives against Human Pathogenic Parasites.
Topics: Animals; Antiparasitic Agents; Dihydropyridines; Drug Development; Humans; Parasites | 2023 |
22 trial(s) available for 1,4-dihydropyridine and dihydropyridines
| Article | Year |
|---|---|
Losartan potassium as initial therapy in patients with severe hypertension.
Topics: Adolescent; Adult; Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Atenolol; Biphenyl Compounds; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Renin-Angiotensin System; Tetrazoles; Treatment Outcome | 1995 |
Association of circulating endothelium and noradrenaline with increased calcium-channel binding sites in the placental bed in pre-eclampsia.
Topics: Adult; Autoradiography; Binding Sites; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Endothelin-1; Female; Humans; Norepinephrine; Placenta; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Third | 1998 |
Power spectral analysis of the heart rate in hypertensive patients with and without left ventricular hypertrophy: the effect of a left ventricular mass reduction.
Topics: Adolescent; Adult; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Dihydropyridines; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Heart Rate; Heart Ventricles; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Organ Size | 1998 |
Systolic Hypertension in Europe (Syst-Eur) trial phase 2: objectives, protocol, and initial progress. Systolic Hypertension in Europe Investigators.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Determination; Calcium Channel Blockers; Dihydropyridines; Drug Administration Schedule; Drug Therapy, Combination; Enalapril; Europe; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Male; Nifedipine; Prognosis; Survival Rate; Treatment Outcome | 1999 |
Isradipine, a dihydropyridine-class calcium channel antagonist, attenuates some of d-methamphetamine's positive subjective effects: a preliminary study.
Topics: Adrenergic Agents; Adult; Affect; Calcium Channel Blockers; Cross-Over Studies; Dihydropyridines; Double-Blind Method; Drug Antagonism; Female; Humans; Isradipine; Male; Methamphetamine; Middle Aged; Reinforcement, Psychology; Reward; Substance-Related Disorders | 1999 |
The effect of pravastatin on renal function and lipid metabolism in patients with renal dysfunction with hypertension and hyperlipidemia. Pravastatin and Renal Function Research Group.
Topics: Blood Urea Nitrogen; Calcium Channel Blockers; Cholesterol; Creatinine; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypertension; Kidney Diseases; Male; Middle Aged; Pravastatin; Treatment Outcome | 1999 |
Effects of isradipine, a dihydropyridine-class calcium channel antagonist, on D-methamphetamine-induced cognitive and physiological changes in humans.
Topics: Adult; Amphetamine-Related Disorders; Calcium Channel Blockers; Cardiovascular Physiological Phenomena; Cognition; Cross-Over Studies; Dihydropyridines; Double-Blind Method; Female; Humans; Isradipine; Male; Methamphetamine; Middle Aged; Nootropic Agents | 2000 |
Pilot study to evaluate a water displacement technique to compare effects of diuretics and ACE inhibitors to alleviate lower extremity edema due to dihydropyridine calcium antagonists.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Body Water; Calcium Channel Blockers; Dihydropyridines; Diuretics; Drug Therapy, Combination; Edema; Female; Humans; Leg; Male; Middle Aged; Pilot Projects; Treatment Outcome | 2001 |
Dihydropyridine calcium-channel blockers for antihypertensive treatment in older patients--evidence from the Systolic Hypertension in Europe Trial.
Topics: Aged; Alcohol Drinking; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Double-Blind Method; Europe; Female; Humans; Hypertension; Male; Middle Aged; Nitrendipine; Prognosis; Smoking; Treatment Outcome | 2001 |
Impact of an ACE inhibitor and calcium antagonist on microalbuminuria and lipid subfractions in type 2 diabetes: a randomised, multi-centre pilot study.
Topics: Aged; Albuminuria; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Apolipoproteins; Apoprotein(a); Benzazepines; Calcium Channel Blockers; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Type 2; Dihydropyridines; Female; Humans; Lipoprotein(a); Male; Middle Aged; Pilot Projects; Triglycerides | 2002 |
Heart rate in hypertensive patients treated with ACE inhibitors and long-acting dihydropyridine calcium antagonists.
Topics: Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged | 2002 |
Acute and sustained effects of dihydropyridine-type calcium channel antagonists on oxidative stress in systemic sclerosis.
Topics: Adult; Aged; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Male; Malondialdehyde; Middle Aged; Oxidation-Reduction; Oxidative Stress; Scleroderma, Systemic; Sulfhydryl Compounds; Time Factors | 2004 |
Effects of immediate versus delayed antihypertensive therapy on outcome in the Systolic Hypertension in Europe Trial.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus; Dihydropyridines; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Enalapril; Europe; Female; Follow-Up Studies; Heart Failure; Humans; Hydrochlorothiazide; Hypertension; Incidence; Linear Models; Male; Myocardial Infarction; Nitrendipine; Stroke; Survival Rate; Time Factors; Treatment Outcome | 2004 |
BENEDICT in the treatment of hypertension.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Creatinine; Diabetes Mellitus, Type 2; Dihydropyridines; Double-Blind Method; Drug Therapy, Combination; Follow-Up Studies; Glycated Hemoglobin; Humans; Hypertension; Indoles; Treatment Outcome; Verapamil | 2005 |
The relationship between magnitude of proteinuria reduction and risk of end-stage renal disease: results of the African American study of kidney disease and hypertension.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Black or African American; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Disease Progression; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Hypertension; Kidney Failure, Chronic; Male; Metoprolol; Middle Aged; Prognosis; Proteinuria; Ramipril; Risk Factors; Treatment Outcome; United States | 2005 |
Does the MOSES trial establish superiority of AT1-receptor blockers over dihydropyridine/calcium antagonists in secondary stroke prevention?
Topics: Angiotensin II Type 1 Receptor Blockers; Apoptosis; Blood Pressure; Calcium; Cardiovascular Diseases; Dihydropyridines; Humans; Prevalence; Recurrence; Risk; Stroke; Time Factors; Treatment Outcome | 2006 |
Randomized study of angiotensin II type 1 receptor blocker vs dihydropiridine calcium antagonist for the treatment of paroxysmal atrial fibrillation in patients with hypertension.
Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Atrial Fibrillation; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Dihydropyridines; Humans; Hypertension; Secondary Prevention; Tetrazoles | 2006 |
[Hypotensive efficacy and tolerability of combination of dihydropyridine and non-dihydropyridine calcium antagonists in the treatment of patients with arterial hypertension].
Topics: Adult; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dihydropyridines; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Nifedipine; Obesity; Treatment Outcome; Verapamil | 2007 |
Rationale, study design and implementation of the COLM study: the combination of OLMesartan and calcium channel blocker or diuretic in high-risk elderly hypertensive patients.
Topics: Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Diuretics; Double-Blind Method; Drug Therapy, Combination; Endpoint Determination; Female; Humans; Hypertension; Imidazoles; Japan; Male; Prospective Studies; Risk; Tetrazoles | 2009 |
Dihydropyridine calcium channel blockers inhibit non-esterified-fatty-acid-induced endothelial and rheological dysfunction.
Topics: Adult; Antioxidants; Calcium Channel Blockers; Cell Line; Cross-Over Studies; Dihydropyridines; Double-Blind Method; Endothelium, Vascular; Fatty Acids, Nonesterified; Hemorheology; Humans; Leukocytes; Male; Oxidative Stress; Phosphorylation; Transcription Factor RelA; Young Adult | 2013 |
Effects of combination of perindopril, indapamide, and calcium channel blockers in patients with type 2 diabetes mellitus: results from the Action In Diabetes and Vascular Disease: Preterax and Diamicron Controlled Evaluation (ADVANCE) trial.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dihydropyridines; Drug Combinations; Drug Therapy, Combination; Female; Gliclazide; Humans; Hypertension; Hypoglycemic Agents; Indapamide; Male; Middle Aged; Perindopril; Proportional Hazards Models | 2014 |
Antiplatelet effect of clopidogrel can be reduced by calcium-channel blockers.
Topics: Aged; Aged, 80 and over; Blood Platelets; Calcium Channel Blockers; Clopidogrel; Dihydropyridines; Drug Interactions; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
958 other study(ies) available for 1,4-dihydropyridine and dihydropyridines
| Article | Year |
|---|---|
P-type calcium channels in the somata and dendrites of adult cerebellar Purkinje cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channels; Dendrites; Dihydropyridines; Electric Stimulation; Electrophysiology; Evoked Potentials; Female; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Purkinje Cells | 1992 |
Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype.
Topics: Amino Acid Sequence; Animals; Calcium Channels; Cloning, Molecular; Dihydropyridines; DNA; Gene Expression; Humans; Macromolecular Substances; Molecular Sequence Data; Neurons; Nucleic Acid Hybridization; Oocytes; Polymerase Chain Reaction; RNA, Messenger; Tissue Distribution; Transcription, Genetic; Xenopus laevis | 1992 |
Omega-conotoxin GVIA blocks a Ca2+ current in bovine chromaffin cells that is not of the "classic" N type.
Topics: Adrenal Glands; Animals; Calcium Channel Blockers; Calcium Channels; Cattle; Cells, Cultured; Chromaffin System; Dihydropyridines; Electric Conductivity; Membrane Potentials; Nisoldipine; omega-Conotoxin GVIA; Peptides, Cyclic; Potassium | 1992 |
Ion dependence of the partially purified mitochondrial dihydropyridine Ca2+ antagonist receptor.
Topics: Animals; Anions; Binding Sites; Calcium Channels; Cations; Dihydropyridines; Guinea Pigs; Kinetics; Mitochondria, Liver; Nitrendipine; Receptors, Nicotinic; Tritium | 1992 |
A unique fluorescent phenylalkylamine probe for L-type Ca2+ channels. Coupling of phenylalkylamine receptors to Ca2+ and dihydropyridine binding sites.
Topics: Animals; Binding Sites; Calcium; Calcium Channels; Chromatography, Affinity; Dihydropyridines; Fluorescent Dyes; Kinetics; Microsomes; Muscles; Nitriles; Phenethylamines; Rabbits; Radioligand Assay | 1992 |
Erythromycin stimulates ileal motility by activation of dihydropyridine-sensitive calcium channels.
Topics: Animals; Blood Gas Analysis; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Erythromycin; Gastrointestinal Motility; Ileum; Ion Channel Gating; Rabbits | 1992 |
Expression of dihydropyridine-sensitive brain calcium channels in the rat central nervous system.
Topics: Amino Acid Sequence; Animals; Brain; Calcium Channels; Dihydropyridines; Immunohistochemistry; Molecular Sequence Data; Nucleic Acid Hybridization; Rats; RNA, Messenger | 1992 |
Interaction of pinaverium (a quaternary ammonium compound) with 1,4-dihydropyridine binding sites in rat ileum smooth muscle.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; Diltiazem; Ileum; In Vitro Techniques; Isradipine; Kinetics; Morpholines; Muscle, Smooth; Parasympatholytics; Rats; Receptors, Nicotinic; Saponins | 1992 |
Inhibition of N- and L-type calcium channels by muscarinic receptor activation in rat sympathetic neurons.
Topics: Animals; Calcium Channels; Dihydropyridines; Electric Conductivity; Ganglia, Sympathetic; Male; Neurons; Norepinephrine; Oxotremorine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Muscarinic | 1992 |
Dihydropyridine binding of the calcium channel complex from skeletal muscle is modulated by subunit interaction.
Topics: Animals; Calcium Channels; Chromatography, Affinity; Digitonin; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Muscle Proteins; Protein Binding; Protein Conformation; Rabbits; Receptors, Nicotinic | 1992 |
TTX-sensitive Na+ channels and Ca2+ channels of the L- and N-type underlie the inward current in acutely dispersed coeliac-mesenteric ganglia neurons of adult rats.
Topics: Action Potentials; Animals; Calcium Channels; Dihydropyridines; Ganglia, Sympathetic; Ion Channel Gating; Male; Mesentery; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Sodium; Sodium Channels; Tetrodotoxin | 1992 |
Two classes of gating current from L-type Ca channels in guinea pig ventricular myocytes.
Topics: Animals; Biological Transport; Calcium; Calcium Channels; Cell Membrane Permeability; Cells, Cultured; Dihydropyridines; Electric Conductivity; Gallopamil; Guinea Pigs; Heart Ventricles; Ion Channel Gating; Membrane Potentials; Muscle, Smooth, Vascular; Sodium; Sodium Channels; Ventricular Function | 1992 |
Modulation of dihydropyridine-sensitive gastric mucosal calcium channels by GM1-ganglioside.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Cell Membrane; Dihydropyridines; G(M1) Ganglioside; Gastric Mucosa; Isradipine; Lanthanum; Liposomes; Male; Osmolar Concentration; Phosphatidylcholines; Rats; Rats, Inbred Strains | 1992 |
The gene for the dihydropyridine-sensitive calcium channel alpha 2 subunit (CCHL2A) maps to the proximal region of mouse chromosome 5.
Topics: Animals; Calcium Channels; Chromosome Mapping; Cricetinae; Crosses, Genetic; Dihydropyridines; DNA; DNA Probes; Hybrid Cells; Mice; Nucleic Acid Hybridization | 1992 |
ANP-(7-23) stimulates a DHP-sensitive Ca2+ conductance and reduces cellular cAMP via a cGMP-independent mechanism.
Topics: Aldosterone; Animals; Atrial Natriuretic Factor; Calcium; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dihydropyridines; Electric Conductivity; Intracellular Membranes; Peptide Fragments; Zona Glomerulosa | 1992 |
Cyclic AMP-dependent phosphorylation and regulation of the cardiac dihydropyridine-sensitive Ca channel.
Topics: Animals; Calcium Channels; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dihydropyridines; Immunoblotting; Kinetics; Myocardium; Phosphorylation; Precipitin Tests; Rabbits | 1992 |
Characterization of voltage-dependent calcium currents in mouse motoneurons.
Topics: Amiloride; Animals; Barium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Electrophysiology; Female; Mice; Motor Neurons; Nicotinic Acids; omega-Conotoxins; Oxadiazoles; Peptides, Cyclic; Pregnancy; Synaptic Transmission | 1992 |
Structural characterization of the dihydropyridine receptor-linked calcium channel from porcine heart.
Topics: Animals; Antibodies; Calcium Channels; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Myocardium; Phosphorylation; Precipitin Tests; Protein Kinases; Swine | 1992 |
Unaltered hippocampal dihydropyridine and omega-conotoxin GVIA binding sites after repeated electroconvulsive shock in rats.
Topics: Animals; Arousal; Calcium Channel Blockers; Calcium Channels; Dihydroalprenolol; Dihydropyridines; Electroshock; Hippocampus; Male; omega-Conotoxin GVIA; Peptides, Cyclic; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Neurotransmitter | 1992 |
Background calcium permeable channels in glomerulosa cells from adrenal gland.
Topics: Aldosterone; Animals; Biological Transport; Calcium; Calcium Channels; Cattle; Cell Membrane Permeability; Cells, Cultured; Dihydropyridines; Electric Conductivity; Membrane Potentials; Nifedipine; Rats; Zona Glomerulosa | 1992 |
Density of 1,4-dihydropyridine receptors decreases in the hearts of aging hamsters.
Topics: Aging; Allosteric Site; Animals; Calcium Channels; Cricetinae; Dihydropyridines; Diltiazem; In Vitro Techniques; Kinetics; Male; Myocardium; Nifedipine; Verapamil | 1992 |
Bis(benzylisoquinoline) analogs of tetrandrine block L-type calcium channels: evidence for interaction at the diltiazem-binding site.
Topics: Alkaloids; Animals; Benzylisoquinolines; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Fluspirilene; Gallopamil; Isoquinolines; Isradipine; Kinetics; Molecular Conformation; Molecular Structure; Myocardium; Sarcolemma; Swine | 1992 |
Purification of the cardiac 1,4-dihydropyridine receptor using immunoaffinity chromatography with a monoclonal antibody against the alpha 2 delta subunit of the skeletal muscle dihydropyridine receptor.
Topics: Animals; Binding Sites; Calcium Channels; Chromatography, Affinity; Dihydropyridines; Myocardium; Rabbits; Sarcolemma; Swine | 1992 |
Activation of dihydropyridine-sensitive parotid salivary gland calcium channels by epidermal growth factor.
Topics: Animals; Calcium; Calcium Channels; Calcium Radioisotopes; Cell Membrane; Dihydropyridines; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Isradipine; Lanthanum; Liposomes; Male; Parotid Gland; Phosphorylation; Rats; Rats, Sprague-Dawley; Tyrosine | 1992 |
Testosterone sensitive dihydropyridine binding in the Harderian gland of the male hamster.
Topics: Animals; Calcium; Calcium Channels; Cricetinae; Dihydropyridines; Female; Harderian Gland; Ion Channel Gating; Kinetics; Male; Mesocricetus; Orchiectomy; Protein Binding; Sex Factors; Testosterone | 1992 |
[Two-phase effect of endothelin-1 on resistance of coronary vessels in anesthesized rats with intact chest].
Topics: Animals; Calcium Channels; Coronary Circulation; Coronary Vessels; Dihydropyridines; Endothelins; Male; Rats; Rats, Sprague-Dawley; Vascular Resistance; Vasodilation | 1992 |
The gene for the alpha 1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (Cchl1a3) maps to mouse chromosome 1.
Topics: Animals; Blotting, Southern; Calcium Channels; Chromosome Mapping; Cricetinae; Dihydropyridines; DNA; DNA Probes; Female; Haplotypes; Hybrid Cells; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Muscles | 1992 |
Photoaffinity labeling of the partially purified mitochondrial phenylalkylamine calcium antagonist receptor.
Topics: Affinity Labels; Azides; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Mitochondria; Verapamil | 1992 |
P-type voltage-dependent calcium channel mediates presynaptic calcium influx and transmitter release in mammalian synapses.
Topics: Action Potentials; Animals; Arginine; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Dihydropyridines; Electric Stimulation; Evoked Potentials; Magnesium; Male; Mice; Neuromuscular Junction; Neurotoxins; Neurotransmitter Agents; omega-Conotoxins; Peptides, Cyclic; Phrenic Nerve; Polyamines; Potassium; Purkinje Cells; Spermidine; Synapses; Synaptosomes | 1992 |
P-glycoprotein possesses a 1,4-dihydropyridine-selective drug acceptor site which is alloserically coupled to a vinca-alkaloid-selective binding site.
Topics: Allosteric Site; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Drug Resistance; Humans; Kinetics; Lung Neoplasms; Membrane Glycoproteins; Tumor Cells, Cultured; Vinblastine | 1992 |
Native-type DHP-sensitive calcium channel currents are produced by cloned rat aortic smooth muscle and cardiac alpha 1 subunits expressed in Xenopus laevis oocytes and are regulated by alpha 2- and beta-subunits.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta; Calcium Channels; Cloning, Molecular; Dihydropyridines; Electric Conductivity; Female; Gene Expression Regulation; Muscle, Smooth, Vascular; Myocardium; Oocytes; Rabbits; Rats; Xenopus laevis | 1992 |
Pharmacologic and radioligand binding studies of 1,4-dihydropyridines in rat cardiac and vascular preparations: stereoselectivity and voltage dependence of antagonist and activator interactions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Arteries; Binding, Competitive; Calcium Channel Blockers; Dihydropyridines; Drug Antagonism; Heart; In Vitro Techniques; Isradipine; Male; Muscle Contraction; Nifedipine; Radioligand Assay; Rats | 1992 |
Regulation of arterial tone by activation of calcium-dependent potassium channels.
Topics: Animals; Arteries; Calcium; Cerebral Arteries; Charybdotoxin; Dihydropyridines; Electric Conductivity; Membrane Potentials; Muscle, Smooth, Vascular; Nimodipine; Peptides; Potassium Channels; Rabbits; Scorpion Venoms; Tetraethylammonium; Tetraethylammonium Compounds; Vasoconstriction | 1992 |
Dihydropyridine-sensitive L-type Ca2+ channels in human foreskin fibroblast cells. Characterization of activation with the growth factor Lys-bradykinin.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcium Channels; Cells, Cultured; Dihydropyridines; Fibroblasts; Fura-2; Humans; Ion Channel Gating; Kallidin; Nitrendipine | 1992 |
Angiotensin II receptor-mediated calcium influx in bovine adrenal glomerulosa cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Calcium; Calcium Channels; Cattle; Cells, Cultured; Dihydropyridines; GTP-Binding Proteins; Imidazoles; Lanthanum; Losartan; Pertussis Toxin; Receptors, Angiotensin; Tetrazoles; Virulence Factors, Bordetella; Zona Glomerulosa | 1992 |
Kinetic and pharmacological properties of high- and low-threshold calcium channels in primary cultures of rat hippocampal neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amiloride; Animals; Calcium Channel Blockers; Calcium Channels; Cell Membrane Permeability; Cells, Cultured; Dihydropyridines; Electrophysiology; Hippocampus; Kinetics; Neurons; Nickel; omega-Conotoxin GVIA; Peptides, Cyclic; Rats | 1992 |
1,4-Dihydropyridines modulate GTP hydrolysis by Go in neuronal membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Baclofen; Calcium Channels; Cell Membrane; Cerebral Cortex; Dihydropyridines; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Immune Sera; Male; Neurons; Rats; Rats, Inbred Strains | 1992 |
Evidence for the presence of regional differences in the calcium antagonist receptors in lower urinary tract smooth muscle.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Carbachol; Dihydropyridines; Drug Interactions; Female; Isradipine; Muscle Contraction; Muscle, Smooth; Nifedipine; Rabbits; Urinary Tract | 1992 |
Excitation-contraction coupling in a pre-vertebrate twitch muscle: the myotomes of Branchiostoma lanceolatum.
Topics: Animals; Blotting, Western; Calcium; Calcium-Transporting ATPases; Cell Membrane; Cell Movement; Chordata, Nonvertebrate; Dihydropyridines; Membrane Potentials; Microsomes; Muscle Contraction; Nifedipine; Ryanodine; Verapamil | 1992 |
QSAR, diagnostic statistics and molecular modelling of 1,4-dihydropyridine calcium antagonists: a difficult road ahead.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Models, Molecular; Molecular Conformation; Structure-Activity Relationship | 1992 |
High affinity block of myocardial L-type calcium channels by the spider toxin omega-Aga-toxin IIIA: advantages over 1,4-dihydropyridines.
Topics: Agatoxins; Animals; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Felodipine; Guinea Pigs; Heart Atria; In Vitro Techniques; Ion Channel Gating; Male; Myocardium; Spider Venoms; Substrate Specificity | 1992 |
Low-affinity binding sites for 1,4-dihydropyridines in skeletal muscle transverse tubule membranes revealed by changes in the fluorescence of felodipine.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Cations; Cell Membrane; Dihydropyridines; Felodipine; Fluorescent Dyes; Isradipine; Kinetics; Muscles; Rabbits; Spectrometry, Fluorescence | 1992 |
Interactions of the neurotoxin MPTP and its demethylated derivative (PTP) with monoamine oxidase-B.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cattle; Dihydropyridines; Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction | 1992 |
GTP gamma S causes contraction of skinned frog skeletal muscle via the DHP-sensitive Ca2+ channels of sealed T-tubules.
Topics: Animals; Binding Sites; Binding, Competitive; Caffeine; Calcium Channels; Dihydropyridines; Egtazic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Microtubules; Muscle Contraction; Nicardipine; Pertussis Toxin; Photolysis; Rana pipiens; Rana temporaria; Virulence Factors, Bordetella | 1991 |
Kinetics of binding of dihydropyridine calcium channel ligands to skeletal muscle membranes: evidence for low-affinity sites and for the involvement of G proteins.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Isradipine; Kinetics; Ligands; Membrane Proteins; Microsomes; Muscles; Nitrendipine; Oxadiazoles; Rabbits; Receptors, Nicotinic; Stereoisomerism; Thionucleotides | 1991 |
Reversible uncoupling of inactivation in N-type calcium channels.
Topics: Animals; Barium; Calcium Channels; Dihydropyridines; Electric Conductivity; Ganglia, Sympathetic; Ion Channel Gating; Kinetics; Neurons; omega-Conotoxins; Peptides, Cyclic; Rats | 1991 |
Cytosolic calcium regulates a potassium current in corn (Zea mays) protoplasts.
Topics: Biological Transport, Active; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cytosol; Dihydropyridines; Isotopes; Lanthanum; Membrane Potentials; Plants; Potassium; Protoplasts; Zea mays | 1991 |
Parathyroid hormone-stimulated cadmium accumulation in Madin-Darby canine kidney cells.
Topics: Animals; Cadmium; Calcium Channels; Cells, Cultured; Dihydropyridines; Dogs; Kidney; Membrane Potentials; Parathyroid Hormone; Stimulation, Chemical | 1991 |
Glucocorticoids increase Ca2+ uptake and [3H]dihydropyridine binding in A7r5 vascular smooth muscle cells.
Topics: Amiloride; Analysis of Variance; Androstanols; Animals; Calcium; Calcium Channels; Cell Count; Cell Line; Cycloheximide; Dactinomycin; Dexamethasone; Dihydropyridines; Electric Conductivity; Glucocorticoids; Indomethacin; Kinetics; Muscle, Smooth, Vascular; Potassium; Proteins; Rats; Receptors, Glucocorticoid; Spironolactone; Water | 1991 |
Effects of denervation on the contents of cholesterol and membrane systems involved in muscle contraction in rabbit fast-twitch sarcotubular system.
Topics: Acetylcholinesterase; Animals; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Calsequestrin; Chemical Fractionation; Cholesterol; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Male; Muscle Contraction; Muscle Denervation; Muscles; Organ Size; Rabbits; Sarcoplasmic Reticulum; Sodium-Potassium-Exchanging ATPase | 1991 |
Tissue-specific expression of high-voltage-activated dihydropyridine-sensitive L-type calcium channels.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Calcium Channels; Cell Line; Cloning, Molecular; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Molecular Sequence Data; Nucleic Acid Hybridization; Organ Specificity; Polymerase Chain Reaction; Rabbits; RNA Probes; RNA, Messenger; Transcription Factors | 1991 |
Assignment of the human gene for the alpha 1 subunit of the cardiac DHP-sensitive Ca2+ channel (CCHL1A1) to chromosome 12p12-pter.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium Channels; Chromosome Mapping; Chromosomes, Human, Pair 12; Cricetinae; Cricetulus; Dihydropyridines; Genes; Genes, Lethal; Humans; Hybrid Cells; Mice; Mice, Mutant Strains; Molecular Sequence Data; Muscular Diseases; Myocardium; Polymerase Chain Reaction; Rabbits; Sequence Homology, Nucleic Acid; Species Specificity | 1991 |
Identification of 1,4-dihydropyridine binding regions within the alpha 1 subunit of skeletal muscle Ca2+ channels by photoaffinity labeling with diazipine.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Antibodies; Azirines; Calcium Channels; Cell Membrane; Dihydropyridines; Lipid Bilayers; Macromolecular Substances; Models, Structural; Molecular Sequence Data; Muscles; Peptides; Protein Conformation; Rabbits; Receptors, Nicotinic | 1991 |
Cloning and tissue-specific expression of the brain calcium channel beta-subunit.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Calcium Channels; Cloning, Molecular; Cricetinae; Dihydropyridines; Gene Expression; Humans; Molecular Sequence Data; Rabbits; Rats; Receptors, Nicotinic; Sequence Homology, Nucleic Acid; Sheep | 1991 |
Inhibition of voltage-dependent Ca2+ currents and activation of pertussis toxin-sensitive G-proteins via muscarinic receptors in GH3 cells.
Topics: Affinity Labels; Animals; Azides; Calcium Channels; Carbachol; Cell Line; Dihydropyridines; Electric Conductivity; GTP-Binding Proteins; Guanosine Triphosphate; Molecular Weight; Pertussis Toxin; Photochemistry; Pituitary Gland; Prolactin; Rats; Receptors, Muscarinic; Virulence Factors, Bordetella | 1991 |
More von Willebrand factor type A domains? Sequence similarities with malaria thrombospondin-related anonymous protein, dihydropyridine-sensitive calcium channel and inter-alpha-trypsin inhibitor.
Topics: Amino Acid Sequence; Animals; Calcium Channels; Dihydropyridines; Humans; Molecular Sequence Data; Platelet Membrane Glycoproteins; Protozoan Proteins; Receptors, Nicotinic; Sequence Alignment; Thrombospondins; Trypsin Inhibitors; von Willebrand Factor | 1991 |
Beta-adrenergic receptor-G protein-adenylate cyclase complex in experimental canine congestive heart failure produced by rapid ventricular pacing.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Catecholamines; Dihydropyridines; Dobutamine; Dogs; Electric Stimulation; GTP-Binding Proteins; Heart Failure; Heart Rate; Hemodynamics; Pertussis Toxin; Receptors, Adrenergic, beta; Virulence Factors, Bordetella | 1991 |
Postnatal maturation of excitation-contraction coupling in rat ventricle in relation to the subcellular localization and surface density of 1,4-dihydropyridine and ryanodine receptors.
Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Dihydropyridines; Heart Ventricles; Isradipine; Myocardial Contraction; Myocardium; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Cholinergic; Ryanodine; Ryanodine Receptor Calcium Release Channel; Subcellular Fractions; Ventricular Function | 1991 |
Modulation of [3H]dihydropyridine binding by activation of protein kinase C in vascular smooth muscle.
Topics: Aluminum; Animals; Binding Sites; Calcium Channels; Dihydropyridines; Enzyme Activation; Fluorine; Horses; In Vitro Techniques; Isradipine; Membrane Potentials; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phorbol Esters; Phosphorylation; Portal Vein; Potassium Chloride; Protein Kinase C; Tritium | 1991 |
A prepro-TRH connecting peptide (prepro-TRH 160-169) potentiates TRH-induced TSH release from rat perifused pituitaries by stimulating dihydropyridine- and omega-conotoxin-sensitive Ca2+ channels.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Male; omega-Conotoxins; Peptide Fragments; Peptides, Cyclic; Perfusion; Pituitary Gland; Protein Precursors; Rats; Rats, Inbred Strains; Thyrotropin; Thyrotropin-Releasing Hormone; Virulence Factors, Bordetella | 1991 |
Regulation of intracellular calcium in cerebellar granule neurons: effects of depolarization and of glutamatergic and cholinergic stimulation.
Topics: Acetylcholine; Animals; Animals, Newborn; Calcium; Calcium Channels; Cells, Cultured; Cerebellum; Dihydropyridines; Egtazic Acid; Electrophysiology; Glutamates; Glutamic Acid; Neurons; Potassium; Rats; Receptors, N-Methyl-D-Aspartate | 1991 |
Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insulin-secreting cell line (RINm5F).
Topics: Animals; Calcium; Clonidine; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Epinephrine; GTP-Binding Proteins; Hormones; Insulin; Insulin Secretion; Insulinoma; Membrane Potentials; Pertussis Toxin; Rats; Somatostatin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1991 |
Noradrenaline, somatostatin and opioids inhibit activity of single HVA/N-type calcium channels in excised neuronal membranes.
Topics: Animals; Calcium Channels; Cell Membrane; Dihydropyridines; Enkephalin, Methionine; Guinea Pigs; In Vitro Techniques; Neurons; Norepinephrine; Somatostatin | 1991 |
Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Calcium Channel Blockers; Cholera Toxin; Clone Cells; Dihydropyridines; Electric Conductivity; GTP-Binding Proteins; Heart; In Vitro Techniques; Microscopy, Electron; Myocardium; NAD; Pertussis Toxin; Rats; Virulence Factors, Bordetella | 1991 |
Calcium release from pituitary secretory granules: modulation by thiols, disulfides, and dihydropyridine calcium channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Cattle; Cysteine; Cystine; Cytoplasmic Granules; Dihydropyridines; Disulfides; Dithiothreitol; Glutathione; Hydrogen-Ion Concentration; Mercaptoethanol; Nifedipine; Nimodipine; Pituitary Gland; Potassium Chloride; Sulfhydryl Compounds | 1990 |
Involvement of dihydropyridine-sensitive Ca2+ channels in adenosine-evoked inhibition of acetylcholine release from guinea pig ileal preparation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Acetylcholine; Adenosine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Calcium Channels; Chromatography, High Pressure Liquid; Dihydropyridines; Electric Stimulation; Guinea Pigs; Ileum; Male; Muscle, Smooth; Nifedipine; Physostigmine; Tetrodotoxin; Theophylline | 1990 |
Second messengers involved in genetic regulation of the number of calcium channels in bovine adrenal chromaffin cells in culture.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Glands; Animals; Calcium Channels; Cattle; Cells, Cultured; Chromaffin System; Dihydropyridines; Gene Expression; Inositol Phosphates; Kinetics; Pertussis Toxin; Phorbol Esters; Second Messenger Systems; Up-Regulation; Virulence Factors, Bordetella | 1990 |
Activation of latent Ca2+ channels in renal epithelial cells by parathyroid hormone.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Absorption; Animals; Biological Transport; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Dihydropyridines; Epithelium; Exocytosis; Kidney Tubules, Distal; Kinetics; Mice; Microtubules; Nifedipine; Parathyroid Hormone; Peptide Fragments | 1990 |
Multiple conductance levels of the dihydropyridine-sensitive calcium channel in GH3 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcium Channels; Cell Line; Dihydropyridines; Electric Conductivity; Humans; Nimodipine; Pituitary Gland, Anterior | 1990 |
Hypoxic suppression of K+ currents in type I carotid body cells: selective effect on the Ca2(+)-activated K+ current.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cadmium; Calcium; Calcium Channel Blockers; Carotid Body; Dihydropyridines; Electrophysiology; Hypoxia; Nifedipine; Potassium; Rats | 1990 |
Inhibition of calcium currents in cultured myenteric neurons by neuropeptide Y: evidence for direct receptor/channel coupling.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channels; Cells, Cultured; Dihydropyridines; Fura-2; Membrane Potentials; Myenteric Plexus; Neurons; Neuropeptide Y; Nitrendipine; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Neuropeptide Y; Receptors, Neurotransmitter; Virulence Factors, Bordetella | 1990 |
Dihydropyridine modulation of voltage-activated calcium channels in PC12 cells: effect of pertussis toxin pretreatment.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Gland Neoplasms; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophysiology; Nicardipine; Pertussis Toxin; Pheochromocytoma; Potassium; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1991 |
Calcium currents in the A7r5 smooth muscle-derived cell line.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta; Biological Transport; Calcium; Calcium Channels; Cell Line; Colforsin; Cytosol; Dihydropyridines; Electric Conductivity; Fluorescence; Isoproterenol; Ligands; Muscle, Smooth, Vascular; Nifedipine; Potassium | 1990 |
Distribution of dihydropyridine and omega-conotoxin-sensitive calcium currents in acutely isolated rat and frog sensory neuron somata: diameter-dependent L channel expression in frog.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium Channels; Dihydropyridines; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Kinetics; Membrane Potentials; Mollusk Venoms; Neurons, Afferent; Nimodipine; omega-Conotoxin GVIA; Peptides, Cyclic; Ranidae; Rats; Species Specificity | 1991 |
Multiple types of Ca2+ channels in visceral smooth muscle cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Bufo marinus; Calcium Channels; Dihydropyridines; Electric Conductivity; Gastric Mucosa; In Vitro Techniques; Kinetics; Muscle, Smooth; Stomach | 1991 |
Voltage-dependent calcium currents in Purkinje cells from rat cerebellar vermis.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Barium; Calcium Channels; Cell Separation; Dihydropyridines; Electric Conductivity; Electrophysiology; Nickel; Nimodipine; Nitrendipine; Purkinje Cells; Rats | 1991 |
Acceleration of activation and inactivation by the beta subunit of the skeletal muscle calcium channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Binding Sites; Calcium Channels; Cell Line; Cell Membrane; Dihydropyridines; DNA; Electric Conductivity; Gene Expression; Ion Channel Gating; Isradipine; Kinetics; L Cells; Macromolecular Substances; Muscles; Oxadiazoles; Rabbits; Receptors, Nicotinic; Transfection | 1991 |
Pertussis toxin stimulation of catecholamine release from adrenal medullary chromaffin cells: mechanism may be by direct activation of L-type and G-type calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Cadmium; Calcium Channel Blockers; Calcium Channels; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Dihydropyridines; Electric Conductivity; Membrane Potentials; Nifedipine; Pertussis Toxin; Verapamil; Virulence Factors, Bordetella | 1991 |
Galanin inhibits a dihydropyridine-sensitive Ca2+ current in the RINm5f cell line.
Topics: Animals; Calcium; Calcium Channels; Dihydropyridines; Dose-Response Relationship, Drug; Electric Conductivity; Galanin; In Vitro Techniques; Insulinoma; Islets of Langerhans; Membrane Potentials; Peptides; Rats; Tumor Cells, Cultured | 1991 |
Permeation of Pb2+ through calcium channels: fura-2 measurements of voltage- and dihydropyridine-sensitive Pb2+ entry in isolated bovine chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Calcium Channels; Cattle; Cell Membrane Permeability; Cell Separation; Dihydropyridines; Fura-2; Lead; Membrane Potentials; Nifedipine | 1991 |
Voltage dependent calcium channels in cerebellar granule cell primary cultures.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcium Channels; Cells, Cultured; Cerebellum; Dihydropyridines; Electrophysiology | 1991 |
The beta-adrenergic receptor-regulated 1,4-dihydropyridine calcium channel receptor sites in coronary artery smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding Sites; Calcium Channels; Cell Membrane; Cyclic AMP; Dihydropyridines; Dogs; Guanosine Triphosphate; Isoproterenol; Isradipine; Male; Microsomes; Muscle, Smooth, Vascular; Receptors, Adrenergic, beta | 1991 |
Dihydropyridine-induced release of catecholamines in cardiac tissue.
Topics: Animals; Catecholamines; Dihydropyridines; Electric Stimulation; Guinea Pigs; Heart; In Vitro Techniques; Myocardial Contraction; Myocardium | 1991 |
[Anti-epileptic effect of the new calcium channel blocker IOS-1.1212].
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Dihydropyridines; Epilepsy; Male; Penicillins; Pentylenetetrazole; Rats; Rats, Inbred Strains; Strychnine | 1991 |
Prevention of stroke and brain damage with calcium antagonists in animals.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain Damage, Chronic; Calcium Channel Blockers; Cerebrovascular Disorders; Dihydropyridines; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Isradipine; Male; Prognosis; Pyridines; Rats; Rats, Inbred SHR | 1991 |
Denervation induced changes in level of Ca-antagonists binding cytosolic protein from white skeletal muscle.
Topics: Animals; Calcium Channel Blockers; Cytosol; Denervation; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Isradipine; Microsomes; Muscles; Oxadiazoles; Rabbits; Receptors, Cholinergic | 1991 |
Effect of S-312, a new calcium channel blocker, on the 1,4-dihydropyridine binding sites in porcine basilar blood vessels and rat aortic smooth muscle cells.
Topics: Animals; Aorta; Basilar Artery; Binding Sites; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Isradipine; Muscle, Smooth, Vascular; Nicardipine; Nitrendipine; Oxadiazoles; Rats; Swine | 1991 |
Ca2+ signaling by distinct endothelin peptides in glomerular mesangial cells.
Topics: Animals; Calcium; Calcium Channels; Dihydropyridines; Down-Regulation; Endothelins; Glomerular Mesangium; In Vitro Techniques; Male; Peptides; Protein Kinase C; Protein Precursors; Rats; Rats, Inbred Strains; Signal Transduction; Viper Venoms | 1991 |
Distribution of alpha 1 and alpha 2 (Na+,K+)-ATPase isoforms between the junctional (t-tubular) and non-junctional sarcolemmal domains of rat ventricle.
Topics: 5'-Nucleotidase; Animals; Binding Sites; Cell Fractionation; Dihydropyridines; Heart Ventricles; Isoenzymes; Microsomes; Ouabain; Quinuclidinyl Benzilate; Rats; Sarcolemma; Sodium-Potassium-Exchanging ATPase | 1991 |
Reduced calcium sensitivity of dihydropyridine binding to calcium channels in spontaneously hypertensive rats.
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Isradipine; Male; Microsomes; Muscles; Myocardium; Oxadiazoles; Rats; Rats, Inbred SHR | 1991 |
Ca2+ channels in rat central and peripheral neurons: high-threshold current resistant to dihydropyridine blockers and omega-conotoxin.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Central Nervous System; Differential Threshold; Dihydropyridines; Drug Resistance; Electrophysiology; Kinetics; Neurons; Nitrendipine; omega-Conotoxin GVIA; Osmolar Concentration; Peptides, Cyclic; Peripheral Nerves; Rats | 1991 |
Structural characterization of the dihydropyridine-sensitive calcium channel alpha 2-subunit and the associated delta peptides.
Topics: Animals; Blotting, Western; Calcium Channels; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Glycosylation; Hydrogen-Ion Concentration; Microsomes; Muscles; Peptides; Rabbits | 1991 |
Voltage-dependent inactivation of T-tubular skeletal calcium channels in planar lipid bilayers.
Topics: Animals; Calcium Channels; Dihydropyridines; In Vitro Techniques; Kinetics; Lipid Bilayers; Membrane Potentials; Microsomes; Models, Biological; Muscles; Rabbits; Rats | 1991 |
Microfluorometric and fluorometric lipofuscin spectral discrepancies: a concentration-dependent metachromatic effect?
Topics: Aging; Animals; Dihydropyridines; Evaluation Studies as Topic; Humans; Lipid Peroxidation; Lipofuscin; Malondialdehyde; Microscopy, Fluorescence; Schiff Bases; Spectrometry, Fluorescence | 1991 |
An investigation of the sensitivity of the ouabain-insensitive sodium efflux in single barnacle muscle fibers to pentachlorophenol.
Topics: Animals; Cadmium; Calcium; Calcium Channel Blockers; Cobalt; Cytosol; Dihydropyridines; Egtazic Acid; Gallic Acid; Hydrogen-Ion Concentration; Kinetics; Muscles; Osmolar Concentration; Ouabain; Pentachlorophenol; Ryanodine; Sodium; Stimulation, Chemical; Thoracica; Verapamil | 1991 |
Effects of anti-calcium channel alpha 2-subunit antibodies on calcium flux and 1,4-dihydropyridine binding.
Topics: Animals; Antibodies, Monoclonal; Aorta; Calcium; Calcium Channels; Cells, Cultured; Dihydropyridines; Female; Macromolecular Substances; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Receptors, Nicotinic | 1990 |
Arrhythmia due to hypervagotonia in a fit pharmacology volunteer.
Topics: Adult; Arrhythmias, Cardiac; Dihydropyridines; Drug Evaluation; Eligibility Determination; Humans; Male; Reference Values; Vagus Nerve | 1990 |
Potentiation of etoposide and vincristine by two synthetic 1,4-dihydropyridine derivatives in multidrug-resistant and atypical multidrug-resistant human cancer cells.
Topics: Antineoplastic Agents; Cell Survival; Dihydropyridines; Dioxins; Drug Resistance; Drug Synergism; Etoposide; Humans; Intracellular Fluid; Neoplasms; Tritium; Tumor Cells, Cultured; Vincristine | 1991 |
Novel 1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive activity of 3-[4-(substituted amino)phenylalkyl]ester derivatives.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Male; Rats; Rats, Inbred SHR | 1991 |
In vitro and in vivo investigations of dihydropyridine-based chemical delivery systems for anticonvulsants.
Topics: Animals; Anticonvulsants; Biological Availability; Brain; Dihydropyridines; Dioxolanes; Drug Design; In Vitro Techniques; Liver; Male; Rats; Rats, Inbred Strains | 1991 |
Calcium binding to extracellular sites of skeletal muscle calcium channels regulates dihydropyridine binding.
Topics: Animals; Binding Sites; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Cell Membrane; Dihydropyridines; Edetic Acid; Egtazic Acid; Isradipine; Magnesium; Microsomes; Muscles; Myocardium; Oxadiazoles; Rabbits; Sarcolemma | 1990 |
Menthol blocks dihydropyridine-insensitive Ca2+ channels and induces neurite outgrowth in human neuroblastoma cells.
Topics: Acetylcholinesterase; Axons; Benzofurans; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Division; Cyclohexanols; Dihydropyridines; Fluorescent Dyes; Fura-2; Humans; Menthol; Neuroblastoma; Terpenes; Tumor Cells, Cultured | 1990 |
Binding of [125I]iodipine to parathyroid cell membranes: evidence of a dihydropyridine-sensitive calcium channel.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; Iodine Radioisotopes; Iodobenzenes; Kinetics; Ligands; Nicotinic Acids; Nifedipine; Oxadiazoles; Parathyroid Glands; Stereoisomerism | 1990 |
Cardiac-type excitation-contraction coupling in dysgenic skeletal muscle injected with cardiac dihydropyridine receptor cDNA.
Topics: Animals; Calcium; Calcium Channels; Dihydropyridines; DNA; Electrophysiology; Mice; Muscle Contraction; Muscles; Muscular Diseases; Myocardial Contraction; Myocardium; Receptors, Nicotinic; Sarcoplasmic Reticulum; Transfection | 1990 |
Molecular characterization of 1,4-dihydropyridine-sensitive calcium channels of chick heart and skeletal muscle.
Topics: Animals; Antibodies, Monoclonal; Antigens; Calcium Channels; Chickens; Cross Reactions; Dihydropyridines; Molecular Weight; Muscles; Myocardium; Phosphorylation; Precipitin Tests; Protein Conformation | 1990 |
Heparin binds with high affinity to voltage-dependent L-type Ca2+ channels. Evidence for an agonistic action.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Calcium Channels; Carps; Cell Membrane; Cerebral Cortex; Dihydropyridines; Diltiazem; Electric Conductivity; Guinea Pigs; Heparin; Isradipine; Molecular Sequence Data; Muscles; Myocardium; Nicotinic Antagonists; Oxadiazoles; Polyelectrolytes; Polymers; Rabbits; Receptors, Nicotinic; Stereoisomerism; Verapamil | 1990 |
Subunit structure and localization of dihydropyridine-sensitive calcium channels in mammalian brain, spinal cord, and retina.
Topics: Animals; Antibodies, Monoclonal; Brain; Calcium Channels; Dihydropyridines; Female; Fluorescent Antibody Technique; Immunoenzyme Techniques; Macromolecular Substances; Membrane Proteins; Mice; Mice, Inbred BALB C; Muscles; Neurons; Rabbits; Rats; Rats, Inbred Strains; Retina; Spinal Cord | 1990 |
Permeation in the dihydropyridine-sensitive calcium channel. Multi-ion occupancy but no anomalous mole-fraction effect between Ba2+ and Ca2+.
Topics: Animals; Barium; Calcium; Calcium Channels; Cations, Divalent; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Myocardium; Permeability | 1990 |
Functional expression of dihydropyridine-insensitive calcium channels during PC12 cell differentiation by nerve growth factor (NGF), oncogenic ras, or src tyrosine kinase.
Topics: Animals; Calcium Channels; Cell Differentiation; Cell Line; Dihydropyridines; Genes, ras; Nerve Growth Factors; Neurons; Oncogene Protein p21(ras); Oncogene Protein pp60(v-src); Oncogenes; Rats; RNA, Messenger | 1990 |
Novel mechanism of voltage-dependent gating in L-type calcium channels.
Topics: Action Potentials; Animals; Barium; Calcium Channels; Cations, Divalent; Cell Membrane; Dihydropyridines; Electric Conductivity; Heart; Ion Channel Gating; Kinetics; Membrane Potentials; Rats | 1990 |
Clustering of L-type Ca2+ channels at the base of major dendrites in hippocampal pyramidal neurons.
Topics: Animals; Antibodies, Monoclonal; Calcium Channels; Dendrites; Dihydropyridines; Hippocampus; Immunoenzyme Techniques; Immunosorbent Techniques; Isradipine; Neurons; omega-Conotoxins; Oxadiazoles; Peptides, Cyclic; Rats; Rats, Inbred Strains; Synaptic Membranes | 1990 |
Endothelin isopeptides evoke Ca2+ signaling and oscillations of cytosolic free [Ca2+] in human mesangial cells.
Topics: Calcium; Calcium Channels; Cells, Cultured; Dihydropyridines; Endothelins; Glomerular Mesangium; Humans; Protein Kinase C; Signal Transduction; Viper Venoms | 1990 |
Contributions of two types of calcium channels to synaptic transmission and plasticity.
Topics: Action Potentials; Animals; Aplysia; Cadmium; Calcium Channels; Cells, Cultured; Dihydropyridines; Electric Conductivity; FMRFamide; Motor Neurons; Neuronal Plasticity; Neurons, Afferent; Neuropeptides; Nifedipine; Serotonin; Synapses; Synaptic Transmission | 1990 |
Receptor model for the molecular basis of tissue selectivity of 1, 4-dihydropyridine calcium channel drugs.
Topics: Amino Acid Sequence; Binding Sites; Calcium Channel Blockers; Calcium Channels; Computer Simulation; Dihydropyridines; Drug Design; Models, Molecular; Molecular Conformation; Molecular Structure; Nifedipine; Receptors, Nicotinic; Structure-Activity Relationship; X-Ray Diffraction | 1990 |
Dihydropyridine-sensitive cell volume regulation in proximal tubule: the calcium window.
Topics: Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Female; In Vitro Techniques; Intracellular Membranes; Kidney Tubules; Lanthanum; Rabbits; Time Factors | 1990 |
Calcium currents in normal and dystrophic human skeletal muscle cells in culture.
Topics: Calcium; Cells, Cultured; Dihydropyridines; Dystrophin; Humans; Ion Channel Gating; Kinetics; Male; Membrane Potentials; Muscles; Muscular Dystrophies | 1990 |
In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids.
Topics: Aflatoxins; Chamomile; Chromatography, High Pressure Liquid; Dihydropyridines; Felodipine; Flavanones; Flavins; Flavonoids; Gene Expression Regulation; Hesperidin; Humans; In Vitro Techniques; Kaempferols; Microsomes, Liver; Oils, Volatile; Plants, Medicinal; Quercetin; Transcriptional Activation | 1990 |
High and low affinity states of the dihydropyridine and phenylalkylamine receptors on the cardiac calcium channel and their interconversion by divalent cations.
Topics: Animals; Calcium; Cations, Divalent; Chickens; Dihydropyridines; Heart; Ion Channels; Isradipine; Magnesium; Myocardium; Nifedipine; Nitrendipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1985 |
Stimulation of calcium uptake in PC12 cells by the dihydropyridine agonist BAY K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Gland Neoplasms; Animals; Calcium; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Nifedipine; Nitrendipine; Pheochromocytoma; Pyridines; Rats | 1985 |
Decreased [3H]nitrendipine binding in the brainstem of deoxycorticosterone-NaCl hypertensive rats.
Topics: Animals; Brain Stem; Calcium; Desoxycorticosterone; Dihydropyridines; Hypertension; Ion Channels; Kidney; Kinetics; Male; Myocardium; Nephrectomy; Nifedipine; Nitrendipine; Organ Size; Pyridines; Rats; Sodium Chloride | 1985 |
Profile of the oppositely acting enantiomers of the dihydropyridine 202-791 in cardiac preparations: receptor binding, electrophysiological, and pharmacological studies.
Topics: Animals; Binding, Competitive; Calcium; Dihydropyridines; Dogs; Electric Conductivity; Guinea Pigs; Heart; Ion Channels; Myocardial Contraction; Myocardium; Nifedipine; Nitrendipine; Papillary Muscles; Pyridines; Sarcolemma; Stereoisomerism; Ventricular Function | 1985 |
Effects of nitrendipine on the voltage-sensitive calcium channel in mammalian sensory neurons.
Topics: Action Potentials; Animals; Cells, Cultured; Dihydropyridines; Electric Stimulation; Ethanol; Ganglia, Spinal; Ion Channels; Mice; Nerve Growth Factors; Neurons, Afferent; Nifedipine; Nitrendipine; Pharmaceutical Vehicles; Pyridines; Reaction Time; Temperature | 1985 |
Different types of Ca2+ channels in mammalian skeletal muscle cells in culture.
Topics: Animals; Barium; Calcium; Cells, Cultured; Cobalt; Dihydropyridines; Electric Conductivity; Ion Channels; Membrane Potentials; Muscles; Pyridines; Rats; Tetrodotoxin | 1986 |
The effect of dihydropyridine calcium agonists and antagonists on neuronal voltage sensitive calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aminoquinolines; Animals; Brain Chemistry; Calcium; Calcium Channel Blockers; Cell Line; Dihydropyridines; Electric Stimulation; Glioma; In Vitro Techniques; Ion Channels; Neuroblastoma; Neurons; Nifedipine; Potassium; Pyridines; Rats; Synaptosomes; Verapamil | 1986 |
Purified calcium channels have three allosterically coupled drug receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allosteric Regulation; Amines; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Guinea Pigs; Ion Channels; Isradipine; Muscles; Nifedipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1986 |
Ca2+-channel current and its modification by the dihydropyridine agonist BAY k 8644 in isolated smooth muscle cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Barium; Barium Compounds; Cell Membrane; Cesium; Chlorides; Dihydropyridines; Guinea Pigs; Ileum; In Vitro Techniques; Ion Channels; Membrane Potentials; Muscle, Smooth; Nifedipine; Pyridines | 1986 |
Nerve growth factor modulates the drug sensitivity of neurotransmitter release from PC-12 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bucladesine; Calcium; Cell Differentiation; Dihydropyridines; Nerve Growth Factors; Nifedipine; Nitrendipine; Norepinephrine; Pheochromocytoma; Potassium; Pyridines; Rats; Secretory Rate | 1986 |
Immunochemical analysis of subunit structures of 1,4-dihydropyridine receptors associated with voltage-dependent Ca2+ channels in skeletal, cardiac, and smooth muscles.
Topics: Animals; Antigen-Antibody Complex; Calcium; Calcium Channels; Colon; Dihydropyridines; Immune Sera; Intracellular Membranes; Ion Channels; Kinetics; Macromolecular Substances; Microsomes; Molecular Weight; Muscle, Smooth; Muscles; Myocardium; Pyridines; Rabbits; Receptors, Nicotinic | 1986 |
Calcium channels in muscle cells isolated from rat mesenteric arteries: modulation by dihydropyridine drugs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Dihydropyridines; Ion Channels; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Nitrendipine; Pyridines; Rats | 1986 |
Diphenylhydantoin blocks cardiac calcium channels and binds to the dihydropyridine receptor.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Guinea Pigs; Heart Ventricles; Ion Channels; Myocardium; Phenytoin; Pyridines; Receptors, Nicotinic | 1986 |
Widespread distribution of dihydropyridine-sensitive calcium channels in the central nervous system.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Calcium; Cells, Cultured; Cytosol; Dihydropyridines; Hippocampus; Ion Channels; Mice; Mice, Inbred C57BL; Neurons; Organ Specificity; Pyridines; Rats; Rats, Inbred Strains | 1986 |
Studies on Ca channels in intact cardiac cells: voltage-dependent effects and cooperative interactions of dihydropyridine enantiomers.
Topics: Aging; Animals; Animals, Newborn; Calcium; Cells, Cultured; Dihydropyridines; Heart; Ion Channels; Kinetics; Pyridines; Rats; Stereoisomerism; Structure-Activity Relationship | 1986 |
Calcium agonists and antagonists of the dihydropyridine type: antinociceptive effects, interference with opiate-mu-receptor agonists and neuropharmacological actions in rodents.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aggression; Analgesics; Animals; Anticonvulsants; Behavior, Animal; Calcium Channel Blockers; Dihydropyridines; Female; Motor Activity; Pain Measurement; Postural Balance; Pyridines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1986 |
BAY k 8644, a calcium channel agonist, reverses hypotension in endotoxin-shocked rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Blood Pressure; Dihydropyridines; Dose-Response Relationship, Drug; Male; Microsomes; Myocardium; Nitrendipine; Pyridines; Rats; Rats, Inbred Strains; Shock, Septic | 1986 |
Purification and characterization of the dihydropyridine-sensitive voltage-dependent calcium channel from cardiac tissue.
Topics: Animals; Antigen-Antibody Complex; Avian Proteins; Calcium; Chickens; Dihydropyridines; Immune Sera; Iodoacetamide; Ion Channels; Kinetics; Membrane Proteins; Mercaptoethanol; Myocardium; Pyridines | 1987 |
Neuronal calcium channel inhibitors. Synthesis of omega-conotoxin GVIA and effects on 45Ca uptake by synaptosomes.
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Chickens; Chromatography, High Pressure Liquid; Dihydropyridines; Ion Channels; Mice; Mollusk Venoms; omega-Conotoxin GVIA; Pyridines; Sodium; Synaptosomes | 1987 |
Inhibition of some new cardiotonic agents by tetrodotoxin.
Topics: Animals; Cardiotonic Agents; Dihydropyridines; Dose-Response Relationship, Drug; Guinea Pigs; Heart Atria; Imidazoles; In Vitro Techniques; Ion Channels; Isoproterenol; Milrinone; Myocardial Contraction; Protoveratrines; Pyridines; Pyridones; Quinazolines; Tetrodotoxin | 1986 |
Blockade of Ca2+ and K+ currents in bag cell neurons of Aplysia californica by dihydropyridine Ca2+ antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aplysia; Calcium; Calcium Channel Blockers; Dihydropyridines; Ion Channels; Kinetics; Mathematics; Neurons; Nifedipine; Nisoldipine; Potassium; Pyridines | 1987 |
Synthesis and biological activity of novel calcium channel blockers: 2,5-dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic acid esters and 2,5-dihydro-4-methyl-2-phenyl-1,5-benzodiazepine-3-carboxylic acid esters.
Topics: Action Potentials; Animals; Aorta; Benzodiazepines; Calcium Channel Blockers; Calcium Channels; Carboxylic Acids; Chemical Phenomena; Chemistry; Dihydropyridines; Diltiazem; Guinea Pigs; Ion Channels; Pyridines; Rabbits; Receptors, Nicotinic; Structure-Activity Relationship; Thiazepines | 1987 |
Diethyl 3,6-dihydro-2,4-dimethyl-2,6-methano-1,3-benzothiazocine-5,11- dicarboxylates as calcium entry antagonists: new conformationally restrained analogues of Hantzsch 1,4-dihydropyridines related to nitrendipine as probes for receptor-site conformation
Topics: Animals; Aorta; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Dihydropyridines; Dose-Response Relationship, Drug; Heterocyclic Compounds; Ion Channels; Male; Nitrendipine; Protein Binding; Pyridines; Rats; Rats, Inbred Strains; Sarcolemma; Structure-Activity Relationship; Swine; Terpenes | 1987 |
A comparison between the binding and electrophysiological effects of dihydropyridines on cardiac membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Heart; Ion Channels; Isradipine; Kinetics; Membrane Potentials; Membranes; Myocardium; Nicotinic Acids; Nimodipine; Nitrendipine; Oxadiazoles; Pyridines; Stereoisomerism; Structure-Activity Relationship | 1987 |
Whole-cell and single-channel calcium currents of isolated smooth muscle cells from saphenous vein.
Topics: Animals; Calcium; Differential Threshold; Dihydropyridines; Dogs; Electrophoresis; Female; In Vitro Techniques; Ion Channels; Male; Muscle, Smooth, Vascular; Pyridines; Saphenous Vein | 1987 |
Monoclonal antibody specific for the transverse tubular membrane of skeletal muscle activates the dihydropyridine-sensitive Ca2+ channel.
Topics: Animals; Antibodies, Monoclonal; Calcium; Dihydropyridines; Immunoglobulin G; Ion Channels; Male; Mice; Mice, Inbred BALB C; Muscles; Pyridines; Rabbits; Sarcoplasmic Reticulum | 1987 |
Dihydropyridine-sensitive Ca2+ channels and inositol phospholipid metabolism in ethanol physical dependence.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alcoholism; Animals; Cerebral Cortex; Dihydropyridines; Hydroxydopamines; In Vitro Techniques; Inositol Phosphates; Ion Channels; Male; Muscle Contraction; Muscle, Smooth; Nitrendipine; Oxidopamine; Pyridines; Rats; Rats, Inbred Strains; Sugar Phosphates; Vas Deferens | 1987 |
Renal effects of dihydropyridine-type calcium antagonists.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Humans; Kidney; Pyridines | 1987 |
Dihydropyridine calcium antagonists and agonists in the isolated perfused Dahl rat kidney.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Glomerular Filtration Rate; Hypertension, Renal; In Vitro Techniques; Ion Channels; Kidney; Male; Nitrendipine; Perfusion; Pyridines; Rats; Rats, Inbred Strains; Renal Circulation; Sodium Chloride; Verapamil | 1987 |
Modification by dihydropyridine-type calcium antagonists of the renal hemodynamic response to vasoconstrictors.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Drug Interactions; Glomerular Filtration Rate; In Vitro Techniques; Male; Perfusion; Pyridines; Rats; Rats, Inbred Strains; Renal Circulation; Vasoconstrictor Agents | 1987 |
Renal effects of 1,4-dihydropyridines in animal models of hypertension and renal failure.
Topics: Acute Kidney Injury; Animals; Calcium Channel Blockers; Creatinine; Dihydropyridines; Diuretics; Hypertension; Kidney; Male; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Renin | 1987 |
Analysis of the properties of binding of calcium-channel activators and inhibitors to dihydropyridine receptors in chick heart membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Cations, Divalent; Chickens; Dihydropyridines; Ion Channels; Kinetics; Ligands; Membranes; Myocardium; Pyridines; Receptors, Cell Surface; Temperature | 1987 |
Monoclonal antibody identifies a 200-kDa subunit of the dihydropyridine-sensitive calcium channel.
Topics: Animals; Antibodies, Monoclonal; Calcium; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Ion Channels; Isradipine; Macromolecular Substances; Molecular Weight; Muscles; Oxadiazoles; Pyridines; Rabbits | 1987 |
Dihydropyridine inhibition of neuronal calcium current and substance P release.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Chickens; Dihydropyridines; Electric Stimulation; Ganglia, Spinal; Ion Channels; Kinetics; Neurons; Nifedipine; Pyridines; Substance P | 1987 |
Calcium antagonist binding in cat brain tolerant to electroconvulsive shock.
Topics: Animals; Binding Sites; Brain; Cats; Cerebellum; Cerebral Cortex; Dihydropyridines; Electroshock; Female; Hippocampus; Ion Channels; Male; Nitrendipine; Pyridines; Tissue Distribution | 1987 |
Comparative aspects and temperature dependence of [3H]1,4-dihydropyridine Ca2+ channel antagonist and activator binding to neuronal and muscle membranes.
Topics: Animals; Brain; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Ion Channels; Kinetics; Male; Membranes; Microsomes; Muscle, Smooth; Muscles; Myocardium; Neurons; Rats; Synaptosomes; Thermodynamics | 1987 |
Dihydropyridine-sensitive calcium channels in cardiac and skeletal muscle membranes: studies with antibodies against the alpha subunits.
Topics: Animals; Antibodies; Antigen-Antibody Complex; Calcium; Cattle; Cell Membrane; Dihydropyridines; Heart Ventricles; Ion Channels; Macromolecular Substances; Muscles; Myocardium; Rabbits; Sarcolemma | 1987 |
BAY K 8644 increases release of acetylcholine at the murine neuromuscular junction.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Action Potentials; Animals; Dihydropyridines; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Neuromuscular Junction; Nimodipine; Rats; Rats, Inbred Strains | 1987 |
Regional distribution of calcium channel ligand (1,4-dihydropyridine) binding sites and 45Ca2+ uptake processes in rat brain.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Calcium; Calcium Channels; Caudate Nucleus; Cell Membrane; Cerebellum; Cerebral Cortex; Dihydropyridines; Hippocampus; Male; Nimodipine; Olfactory Bulb; Potassium; Rats; Receptors, Nicotinic; Synaptosomes; Tissue Distribution | 1987 |
Crystal structure of a 1,4-dihydropyridine with enantiomers showing opposite effects on calcium channels: structural features of calcium channel agonists and antagonists.
Topics: Calcium Channel Blockers; Crystallization; Dihydropyridines; Ion Channels; Molecular Conformation; Stereoisomerism; X-Ray Diffraction | 1987 |
Central interactions between dihydropyridines and cholinergic systems in the control of blood pressure in rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Atropine Derivatives; Blood Pressure; Cerebral Ventricles; Dihydropyridines; Hemicholinium 3; Hexamethonium; Hexamethonium Compounds; Hippocampus; In Vitro Techniques; Male; Nicardipine; Potassium; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Reference Values; Species Specificity | 1987 |
Characterization of the electrically evoked release of substance P from dorsal root ganglion neurons: methods and dihydropyridine sensitivity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Chick Embryo; Dihydropyridines; Electric Stimulation; Ganglia, Spinal; Nifedipine; Substance P | 1988 |
Pharmacological characterization of two calcium currents in GH3 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cadmium; Calcium; Cell Line; Dihydropyridines; Electrophysiology; Ion Channels; Nitrendipine; Osmolar Concentration; Pituitary Gland; Rats | 1988 |
Dihydropyridine-sensitive Ca2+ channel in aneurally cultured human muscles. Relationship between high-affinity binding site and inhibition of calcium uptake.
Topics: Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Cells, Cultured; Dihydropyridines; Electrophysiology; Humans; Ion Channels; Isradipine; Muscles; Nitrendipine; Oxadiazoles; Potassium | 1988 |
The iminodipropionitrile (IDPN)-induced dyskinetic syndrome in mice: antagonism by the calcium channel antagonist nifedipine.
Topics: Animals; Binding Sites; Brain; Calcium; Dihydropyridines; Dyskinesia, Drug-Induced; Female; Ion Channels; Mice; Nifedipine; Nitriles | 1988 |
Morphine withdrawal in cortical slices: suppression by Ca2+-channel inhibitors of abstinence-induced [3H]-noradrenaline release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Cerebral Cortex; Dihydropyridines; Disease Models, Animal; In Vitro Techniques; Ion Channels; Morphine; Naloxone; Nimodipine; Norepinephrine; Rats; Substance Withdrawal Syndrome; Tritium | 1988 |
Potassium depolarization elevates cytosolic free calcium concentration in rat anterior pituitary cells through 1,4-dihydropyridine-sensitive, omega-conotoxin-insensitive calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzofurans; Calcium; Calcium Channel Blockers; Cytosol; Dihydropyridines; Fluorescent Dyes; Fura-2; Ion Channels; Magnesium; Male; Membrane Potentials; Mollusk Venoms; omega-Conotoxins; Pituitary Gland, Anterior; Potassium; Rats; Rats, Inbred Strains | 1988 |
Conformational changes associated with ion permeation in L-type calcium channels.
Topics: Animals; Avian Proteins; Calcium; Cations, Monovalent; Cell Line; Dihydropyridines; Guinea Pigs; Ion Channels; Kinetics; Membrane Proteins; Myocardium; Protein Conformation | 1988 |
1,4-Dihydropyridine receptor associated with Ca2+ channels in human embryonic fibroblasts.
Topics: Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Embryo, Mammalian; Fibroblasts; Humans; Ion Channels; Kinetics; Receptors, Nicotinic | 1988 |
The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenylyl Cyclases; Calcium; Cell Membrane; Cholera Toxin; Cyclic AMP; Dihydropyridines; Electric Conductivity; Erythrocytes; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Ion Channels; Lipid Bilayers; Muscles; Myocardium; Phosphorylation; Protein Kinases; Thionucleotides | 1988 |
Altered effect of BAY K 8644 after exposure of the rat aorta to IBMX or Db cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta; Bucladesine; Cyclic AMP; Dihydropyridines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium Chloride; Rats; Rats, Inbred Strains; Theophylline | 1988 |
Kainic acid lesions decrease striatal dopamine receptors and 1,4-dihydropyridine sites.
Topics: Animals; Binding Sites; Calcium Channels; Choline O-Acetyltransferase; Corpus Striatum; Dihydropyridines; Ion Channels; Kainic Acid; Male; Nimodipine; Rats; Receptors, Dopamine; Receptors, Nicotinic; Spiperone | 1988 |
Relationship of dihydropyridine binding sites with calcium-dependent neurotransmitter release in synaptosomes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Aminopyridines; Animals; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; gamma-Aminobutyric Acid; Ion Channels; Isradipine; Lanthanum; Male; Mice; Neurotransmitter Agents; Nifedipine; Nitrendipine; Oxadiazoles; Potassium; Receptors, Nicotinic; Ruthenium Red; Synaptosomes | 1988 |
Multiple calcium channels in synaptosomes: voltage dependence of 1,4-dihydropyridine binding and effects on function.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Dihydropyridines; Ion Channels; Isradipine; Kinetics; Male; Nitrendipine; Oxadiazoles; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Synaptosomes; Verapamil | 1988 |
Direct coupling of a G-protein to dihydropyridine binding sites.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding Sites; Calcium Channels; Cerebral Cortex; Dihydropyridines; GTP-Binding Proteins; Guanosine Triphosphate; Male; Pertussis Toxin; Protein Binding; Rats; Rats, Inbred Strains; Synaptic Membranes; Virulence Factors, Bordetella | 1988 |
Dihydropyridine-sensitive calcium channel activity related to prolactin, growth hormone, and luteinizing hormone release from anterior pituitary cells in culture: interactions with somatostatin, dopamine, and estrogens.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channels; Calcium Radioisotopes; Cells, Cultured; Dihydropyridines; Dopamine; Estradiol; Female; Growth Hormone; Luteinizing Hormone; Male; Nitrendipine; Pituitary Gland, Anterior; Pituitary Hormones, Anterior; Potassium; Prolactin; Rats; Rats, Inbred Strains; Sex Characteristics; Somatostatin | 1988 |
Activation of dihydropyridine-sensitive calcium channels and biphasic cytosolic calcium responses by angiotensin II in rat adrenal glomerulosa cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Calcium; Calcium Channels; Cattle; Cytosol; Dihydropyridines; Ethers; Ionomycin; Kinetics; Male; Nifedipine; Potassium; Rats; Rats, Inbred Strains; Species Specificity; Spectrometry, Fluorescence; Zona Glomerulosa | 1988 |
Reduction of K+-stimulated 45Ca2+ influx in synaptosomes with age involves inactivating and noninactivating calcium channels and is correlated with temporal modifications in protein dephosphorylation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aging; Animals; Calcium; Calcium Channels; Calcium Radioisotopes; Dihydropyridines; Kinetics; Male; Molecular Weight; Nifedipine; Phosphoproteins; Phosphorylation; Potassium; Rats; Rats, Inbred Strains; Synaptosomes | 1989 |
Species differences in the negative inotropic response of 1,4-dihydropyridine calcium channel blockers in myocardium.
Topics: Animals; Calcium Channel Blockers; Depression, Chemical; Dihydropyridines; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Papillary Muscles; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1988 |
Evidence that prejunctional adenosine receptors regulating acetylcholine release from rat hippocampal slices are linked to an N-ethylmaleimide-sensitive G-protein, but not to adenylate cyclase or dihydropyridine-sensitive Ca2+-channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenylyl Cyclases; Animals; Calcium Channel Blockers; Carrier Proteins; Cyclic AMP; Dihydropyridines; Electric Stimulation; Ethylmaleimide; GTP-Binding Proteins; Hippocampus; Male; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Neurotransmitter; Receptors, Purinergic | 1988 |
Endothelin increases single-channel calcium currents in coronary arterial smooth muscle cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channels; Coronary Vessels; Dihydropyridines; Electric Conductivity; Endothelins; Endothelium, Vascular; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Peptides; Second Messenger Systems; Swine | 1989 |
Homologous regulation of voltage-dependent calcium channels by 1,4-dihydropyridines.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcium; Calcium Channels; Cell Line; Dihydropyridines; Kinetics; Membrane Potentials; Pheochromocytoma; Radioligand Assay; Rats; Receptors, Nicotinic | 1989 |
Serotonin modulates calcium-dependent plateau of action potentials recorded from bull frog A-type sensory neurons which is omega-conotoxin GVIA-sensitive, but dihydropyridine-insensitive.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Dihydropyridines; Ganglia, Spinal; In Vitro Techniques; Mollusk Venoms; Neurons, Afferent; Nifedipine; omega-Conotoxin GVIA; Rana catesbeiana; Serotonin; Tetraethylammonium Compounds | 1989 |
Contribution of external and internal Ca2+ to changes in intracellular free Ca2+ produced by mitogens in Swiss 3T3 fibroblasts: the role of dihydropyridine sensitive Ca2+ channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Cell Line; Cytosol; Dihydropyridines; Extracellular Space; Fibroblasts; Mice; Mitogens; Nifedipine; Platelet-Derived Growth Factor | 1989 |
Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amino Acid Sequence; Animals; Calcium Channels; Dihydropyridines; DNA; Electric Conductivity; Female; Gene Expression Regulation; Molecular Sequence Data; Molecular Weight; Muscles; Myocardium; Oocytes; Rabbits; Receptors, Nicotinic; RNA, Messenger; Sequence Homology, Nucleic Acid; Xenopus | 1989 |
Induction of calcium currents by the expression of the alpha 1-subunit of the dihydropyridine receptor from skeletal muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Affinity Labels; Animals; Calcium Channels; Cloning, Molecular; Dihydropyridines; DNA; Electric Conductivity; Gene Expression Regulation; Immunoblotting; L Cells; Macromolecular Substances; Mice; Molecular Weight; Muscles; Receptors, Nicotinic; Transfection; Transformation, Genetic | 1989 |
Effects of dihydropyridine calcium channel ligands on rat brain gamma-aminobutyric acidB receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Baclofen; Binding, Competitive; Calcium Channels; Dihydropyridines; Male; Nifedipine; Rats; Receptors, GABA-A | 1989 |
Calcium currents in single isolated smooth muscle cells from the rabbit ear artery in normal-calcium and high-barium solutions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcium; Calcium Channels; Dihydropyridines; Ear; Electric Conductivity; Membrane Potentials; Muscle, Smooth, Vascular; Nifedipine; Rabbits | 1988 |
Calcium currents in bullfrog sympathetic neurons. I. Activation kinetics and pharmacology.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Cadmium; Calcium Channel Agonists; Calcium Channels; Dihydropyridines; Ganglia, Sympathetic; Kinetics; Membrane Potentials; Neurons; Nifedipine; Rana catesbeiana; Saxitoxin; Second Messenger Systems | 1989 |
The role of dihydropyridine-sensitive voltage-gated calcium channels in potassium-mediated neuronal survival.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Count; Cell Survival; Cells, Cultured; Chick Embryo; Dihydropyridines; Membrane Potentials; Neurons; Potassium | 1989 |
Vitamin D3 metabolites modulate dihydropyridine-sensitive calcium currents in clonal rat osteosarcoma cells.
Topics: 24,25-Dihydroxyvitamin D 3; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcifediol; Calcitriol; Calcium; Calcium Channels; Cell Line; Dihydropyridines; Kinetics; Membrane Potentials; Osteosarcoma; Rats; Tumor Cells, Cultured | 1989 |
Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic beta-cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Dihydropyridines; Electric Conductivity; Glucose; In Vitro Techniques; Islets of Langerhans; Membrane Potentials; Mice | 1989 |
(+)-PN200-110 and ouabain binding sites in purified bovine adrenomedullary plasma membranes and chromaffin cells.
Topics: Adrenal Medulla; Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Cattle; Cell Membrane; Chromaffin System; Dihydropyridines; Isradipine; Kinetics; Ouabain; Oxadiazoles; Stereoisomerism | 1989 |
Extracellularly applied ATP alters the calcium flux through dihydropyridine-sensitive channels in cultured chick myotubes.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Cells, Cultured; Chickens; Cytosol; Dihydropyridines; Egtazic Acid; Kinetics; Muscles | 1989 |
Inhibition by nicardipine of endothelin-mediated inositol phosphate formation and Ca2+ mobilization in smooth muscle cell.
Topics: Animals; Benzofurans; Calcium Channels; Cell Line; Dihydropyridines; Endothelins; Endothelium, Vascular; Fluorescent Dyes; Fura-2; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Muscle, Smooth, Vascular; Nicardipine; Peptides; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Rats; Sugar Phosphates | 1989 |
Molecular modelling of the interaction of dihydropyridine drugs with their receptors.
Topics: Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Drug Design; Models, Molecular; Molecular Conformation; Receptors, Nicotinic; Structure-Activity Relationship | 1989 |
Mechanisms of interaction of permeant ions and protons with dihydropyridine-sensitive calcium channels.
Topics: Animals; Barium; Calcium; Calcium Channels; Cations, Divalent; Cations, Monovalent; Cell Membrane Permeability; Cesium; Dihydropyridines; Electric Conductivity; Guinea Pigs; Kinetics; Potassium; Protons; Sodium | 1989 |
Fast Na+ and slow Ca2+ channels in single uterine muscle cells from pregnant rats.
Topics: Animals; Barium; Calcium Channels; Cells, Cultured; Dihydropyridines; Electric Conductivity; Evoked Potentials; Female; Membrane Potentials; Myometrium; Potassium; Pregnancy; Pregnancy, Animal; Rats; Sodium; Sodium Channels; Tetrodotoxin; Uterus | 1989 |
Pharmacological characterization of the voltage-dependent calcium channel of pancreatic B-cell.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophysiology; Glucose; Insulin; Islets of Langerhans; Male; Mollusk Venoms; Nifedipine; omega-Conotoxin GVIA; Osmolar Concentration; Potassium; Potassium Chloride; Rats; Rats, Inbred Strains; Time Factors | 1989 |
[Voltage-operated Ca2+ channel--its molecular structure and Ca2+ permeation].
Topics: Animals; Calcium; Calcium Channels; Cell Membrane Permeability; Dihydropyridines; Electricity; Mice; Muscles; Phospholipids; Protein Binding; Protein Conformation; Proteins | 1989 |
Dual action (stimulation, inhibition) of D600 on contractility and calcium channels in guinea-pig and cat heart cells.
Topics: Animals; Binding Sites; Calcium Channels; Cats; Dihydropyridines; Epinephrine; Gallopamil; Guinea Pigs; Myocardial Contraction; Myocardium; Stimulation, Chemical | 1989 |
Subunit composition of the purified dihydropyridine binding protein from skeletal muscle.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cell Membrane; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Microsomes; Muscles; Rabbits; Receptors, Cell Surface; Solubility | 1989 |
[3H]PN200-110 and [3H]ryanodine binding and reconstitution of ion channel activity with skeletal muscle membranes.
Topics: Alkaloids; Animals; Calcium Channel Blockers; Calcium Channels; Chloride Channels; Chlorides; Dihydropyridines; Electrophoresis; Isradipine; Lipid Bilayers; Membrane Proteins; Membranes; Muscles; Oxadiazoles; Potassium Channels; Rabbits; Ryanodine; Sarcoplasmic Reticulum; Tritium | 1989 |
Two types of calcium channels coexist in peptide-releasing vertebrate nerve terminals.
Topics: Action Potentials; Animals; Calcium; Calcium Channels; Dihydropyridines; Ion Channel Gating; Male; Nerve Endings; Oxytocin; Pituitary Gland, Posterior; Rats; Vasopressins | 1989 |
Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons.
Topics: Acetylcholine; Animals; Calcium; Calcium Channels; Dihydropyridines; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Ion Channel Gating; Mollusk Venoms; Neurons; omega-Conotoxins; Pheochromocytoma; Rats; Thionucleotides; Tumor Cells, Cultured | 1989 |
The alpha 1 and alpha 2 polypeptides of the dihydropyridine-sensitive calcium channel differ in developmental expression and tissue distribution.
Topics: Animals; Antibodies, Monoclonal; Calcium; Calcium Channels; Dihydropyridines; Gene Expression Regulation; Mice; Mice, Inbred BALB C; Muscle Development; Muscles; Organ Specificity; Receptors, Nicotinic | 1989 |
Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of P-glycoprotein.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Drug Resistance; Humans; Membrane Glycoproteins; Photolysis; Structure-Activity Relationship; Tumor Cells, Cultured; Vincristine; Vindesine | 1989 |
Calcium channels in rat brain synaptosomes: identification and pharmacological characterization. High affinity blockade by organic Ca2+ channel blockers.
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Ion Channels; Male; Nifedipine; Nitrendipine; Norepinephrine; Potassium; Pyridines; Rats; Rats, Inbred Strains; Synaptosomes | 1985 |
Dihydropyridine sensitive calcium channels in a smooth muscle cell line.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cadmium; Calcium; Cell Line; Cobalt; Dihydropyridines; Ion Channels; Muscle, Smooth, Vascular; Nifedipine; Nitrendipine; Potassium; Pyridines; Rats | 1985 |
Role of calcium on protein phosphorylation in collagen-stimulated platelets. Effect of a new dihydropyridine derivative.
Topics: Animals; Blood Platelets; Calcium; Collagen; Dihydropyridines; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits | 1989 |
Whole-cell patch-clamp analysis of voltage-dependent calcium conductances in cultured embryonic rat hippocampal neurons.
Topics: Animals; Calcium; Cells, Cultured; Dihydropyridines; Embryo, Mammalian; Hippocampus; Membrane Potentials; Rats | 1989 |
The effect of hypoxia and of energy depletion on 1,4-dihydropyridine binding sites in rat cardiac membrane fragments.
Topics: 2,4-Dinitrophenol; Allosteric Site; Animals; Dihydropyridines; Dinitrophenols; Energy Metabolism; In Vitro Techniques; Male; Myocardium; Oxidative Phosphorylation; Oxygen; Perfusion; Phosphates; Rats; Rats, Inbred Strains; Uncoupling Agents | 1989 |
Cobalt-sensitive and dihydropyridine-insensitive stimulation of dopamine release from tuberoinfundibular neurons by high extracellular concentrations of barium ions.
Topics: Animals; Barium; Cations, Divalent; Cobalt; Dihydropyridines; Dopamine; Female; Hypothalamus; Nitrendipine; Rats; Rats, Inbred Strains | 1989 |
Purification and affinity labeling of dihydropyridine receptor from rabbit skeletal muscle membranes.
Topics: Affinity Labels; Animals; Calcium Channels; Centrifugation, Density Gradient; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Macromolecular Substances; Membranes; Molecular Weight; Muscles; Photochemistry; Rabbits; Receptors, Nicotinic | 1988 |
Control of expression of the 1,4-dihydropyridine receptor in BC3H1 cells.
Topics: Animals; Binding, Competitive; Calcium Channels; Cell Differentiation; Cell Line; Dihydropyridines; Isradipine; Mice; Muscles; Oxadiazoles; Peptides; Receptors, Nicotinic; Transforming Growth Factors | 1988 |
Developmental changes of the distribution of binding sites for organic Ca2+-channel blockers in cat visual cortex.
Topics: Aging; Animals; Autoradiography; Binding Sites; Calcium Channel Blockers; Calcium Channels; Cats; Dihydropyridines; Image Processing, Computer-Assisted; Isradipine; Oxadiazoles; Receptors, Nicotinic; Visual Cortex | 1988 |
1,4-Dihydropyridine antagonist activities at the calcium channel: a quantitative structure-activity relationship approach.
Topics: Animals; Calcium Channels; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Mathematics; Muscle Contraction; Structure-Activity Relationship | 1988 |
Multiple phosphorylation sites in the 165-kilodalton peptide associated with dihydropyridine-sensitive calcium channels.
Topics: Animals; Binding Sites; Calcium Channels; Dihydropyridines; In Vitro Techniques; Muscles; Phosphorylation; Protein Kinases; Rabbits; Receptors, Nicotinic | 1988 |
[Photoactivated radioactive analogs of calcium antagonists of 1,4-dihydropyridine series: synthesis and covalent labeling of the receptor in rabbit skeletal muscle].
Topics: Affinity Labels; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Muscles; Photochemistry; Rabbits; Radioligand Assay; Receptors, Nicotinic | 1988 |
Role of G-proteins in mediating dihydropyridine receptor coupling with voltage sensitive calcium channels.
Topics: Animals; Calcium Channels; Cell Line; Dihydropyridines; GTP-Binding Proteins; Marine Toxins; Nicardipine; Oxocins; Rats; Receptors, Nicotinic; Verapamil; Virulence Factors, Bordetella | 1988 |
Voltage-dependent Ca2+ channels in primary cultures of cerebellar granule cells: modulatory action by an endogenous ligand.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebellum; Dihydropyridines; Nitrendipine; Rats; Receptors, Nicotinic; Veratridine | 1988 |
Endogenous opiate system and dihydropyridine-induced central regulation of sympathetic tone in rats.
Topics: Animals; Blood Pressure; Dihydropyridines; Endorphins; Hydroxydopamines; Hypotension; Male; Naloxone; Nicardipine; Oxidopamine; Rats; Rats, Inbred SHR; Receptors, Opioid; Sympathetic Nervous System | 1988 |
[Reconstruction of a purified and functionally active dihydropyridine-sensitive calcium channel into liposomes].
Topics: Animals; Biological Transport; Calcium Channels; Dihydropyridines; In Vitro Techniques; Liposomes; Nitrendipine; Rabbits; Receptors, Nicotinic | 1988 |
Noradrenaline modulation of calcium channels in single smooth muscle cells from rabbit ear artery.
Topics: Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Dose-Response Relationship, Drug; Evoked Potentials; Guanosine Triphosphate; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Rabbits; Receptors, Adrenergic | 1988 |
Phencyclidine increases the affinity of dihydropyridine calcium channel antagonist binding in rat brain.
Topics: Animals; Binding Sites; Brain; Calcium; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Kinetics; Magnesium; Male; Nifedipine; Nitrendipine; Phencyclidine; Pyridines; Rats; Rats, Inbred Strains | 1985 |
Characterization of binding sites for two classes of calcium channel antagonists in human forebrain.
Topics: Aniline Compounds; Autoradiography; Binding Sites; Brain; Calcium Channel Blockers; Dihydropyridines; Humans; In Vitro Techniques; Isradipine; Kinetics; Membranes; Oxadiazoles; Pyridines | 1985 |
Combined capillary column gas chromatography/electron capture negative ion chemical ionization mass spectrometry of dihydropyridine calcium antagonists.
Topics: Body Fluids; Calcium Channel Blockers; Chromatography, Gas; Dihydropyridines; Humans; Mass Spectrometry; Oxidation-Reduction; Pyridines | 1986 |
Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents.
Topics: Amlodipine; Animals; Biological Assay; Biological Availability; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Dihydropyridines; Dogs; Guinea Pigs; Hemodynamics; Kinetics; Male; Nifedipine; Pyridines; Rats; Vasoconstriction | 1986 |
Characterization of dihydropyridine binding sites in the rat brain: hypertension and age-dependent modulation of [3H](+)-PN 200-110 binding.
Topics: Aging; Animals; Binding Sites; Brain; Calcium Channel Blockers; Dihydropyridines; Hypertension; Isradipine; Male; Oxadiazoles; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Tritium | 1987 |
Atrial natriuretic peptide in human essential hypertension.
Topics: Adult; Aged; Atrial Natriuretic Factor; Blood Pressure; Dihydropyridines; Female; Heart Rate; Humans; Hypertension; Ketanserin; Male; Middle Aged; Nitrendipine; Pyridines | 1987 |
A novel high affinity class of Ca2+ channel blockers.
Topics: Animals; Bepridil; Binding Sites; Calcium Channel Blockers; Cell Line; Dihydropyridines; Fluspirilene; Isradipine; Kinetics; Muscles; Oxadiazoles; Piperidines; Pyrrolidines; Rabbits; Rats; Structure-Activity Relationship; Thiazines; Verapamil | 1988 |
Effect of divalent cation chelation on dihydropyridine binding in isolated cardiac sarcolemma vesicles.
Topics: Animals; Calcimycin; Calcium; Cations, Divalent; Dihydropyridines; Dogs; Edetic Acid; Hydrogen-Ion Concentration; Isradipine; Magnesium; Myocardium; Nitrendipine; Ouabain; Oxadiazoles; Phosphates; Sarcolemma | 1988 |
Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Dioxanes; Gallopamil; In Vitro Techniques; Nicardipine; Nifedipine; Pyridines; Quinuclidinyl Benzilate; Rats; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Nicotinic; Stereoisomerism | 1985 |
Ca2+ antagonist receptor sites on human red blood cell membranes.
Topics: Binding Sites; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Erythrocyte Membrane; Humans; In Vitro Techniques; Nucleosides; Pyridines; Receptors, Nicotinic; Thioinosine | 1985 |
Kinetics of binding of membrane-active drugs to receptor sites. Diffusion-limited rates for a membrane bilayer approach of 1,4-dihydropyridine calcium channel antagonists to their active site.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Diffusion; Dihydropyridines; Kinetics; Ligands; Lipid Bilayers; Mathematics; Models, Biological; Myocardium; Pyridines; Receptors, Nicotinic; Sarcolemma | 1985 |
Effect of ryodipine on electromechanical parameters of heart and vessels, cAMP phosphodiesterase activity and swelling-contraction cycle of mitochondria.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anura; Calcium Channel Blockers; Cardiovascular Agents; Cattle; Dihydropyridines; Electric Stimulation; Electrophysiology; Heart; In Vitro Techniques; Mitochondria; Mitochondria, Liver; Mitochondrial Swelling; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nicardipine; Nifedipine; Pyridines; Rabbits; Rats | 1985 |
Dihydropyridine binding sites on transverse tubules isolated from triads of rabbit skeletal muscle.
Topics: Animals; Calcium; Calcium Channels; Cell Fractionation; Centrifugation, Density Gradient; Dihydropyridines; Kinetics; Microsomes; Muscles; Organoids; Ouabain; Pyridines; Rabbits; Receptors, Nicotinic; Sarcoplasmic Reticulum | 1985 |
The 1,4-dihydropyridine receptor associated with the skeletal muscle voltage-dependent Ca2+ channel. Purification and subunit composition.
Topics: Animals; Anura; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Chickens; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Isradipine; Microsomes; Molecular Weight; Muscles; Oxadiazoles; Pyridines; Rabbits; Receptors, Nicotinic; Solubility | 1985 |
Comparative autoradiographic distribution of calcium channel antagonist binding sites for 1,4-dihydropyridine and phenylalkylamine in rat, guinea pig and human brain.
Topics: Amines; Animals; Autoradiography; Binding Sites; Brain Chemistry; Calcium Channels; Dihydropyridines; Guinea Pigs; Humans; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Species Specificity | 1985 |
Separation of dihydropyridine binding sites from cardiac junctional sarcoplasmic reticulum.
Topics: Animals; Binding Sites; Calcium Channels; Cats; Dihydropyridines; In Vitro Techniques; Microsomes; Myocardium; Pyridines; Receptors, Muscarinic; Receptors, Nicotinic; Sarcoplasmic Reticulum | 1986 |
Dihydropyridine calcium channel antagonists binding in non-mammalian vertebrates: characterization and relationship to 'peripheral-type' binding sites for benzodiazepines.
Topics: Animals; Brain; Calcium Channels; Columbidae; Dihydropyridines; Female; Kinetics; Lizards; Male; Membranes; Myocardium; Nifedipine; Nitrendipine; Pyridines; Rana catesbeiana; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Nicotinic; Species Specificity; Trout | 1986 |
High-affinity antibodies to the 1,4-dihydropyridine Ca2+-channel blockers.
Topics: Animals; Antibodies; Antibody Specificity; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Nifedipine; Nitrendipine; Pyridines; Rabbits; Receptors, Nicotinic; Structure-Activity Relationship; Tritium | 1986 |
Oxidation of 1,4-dihydropyridines by prostaglandin synthase and the peroxidic function of cytochrome P-450. Demonstration of a free radical intermediate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cytochrome P-450 Enzyme System; Dihydropyridines; Electron Spin Resonance Spectroscopy; Felodipine; Free Radicals; Glutathione; In Vitro Techniques; Male; Microsomes; Nifedipine; Oxidation-Reduction; Oxygen Consumption; Peroxidases; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Inbred Strains | 1986 |
(-)-[3H] desmethoxyverapamil labels multiple calcium channel modulator receptors in brain and skeletal muscle membranes: differentiation by temperature and dihydropyridines.
Topics: Animals; Brain Chemistry; Calcium; Calcium Channels; Cell Membrane; Dihydropyridines; Female; Isradipine; Kinetics; Male; Muscles; Oxadiazoles; Pyridines; Rabbits; Receptors, Nicotinic; Stereoisomerism; Temperature; Tritium; Verapamil | 1986 |
The effects of purified Mojave toxin on rat synaptic membrane (Ca+2 + Mg+2)-ATPase and the dihydropyridine receptor.
Topics: Animals; Ca(2+) Mg(2+)-ATPase; Calcium Channel Blockers; Calcium Channels; Calcium-Transporting ATPases; Crotalid Venoms; Dihydropyridines; Pyridines; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Synaptic Membranes; Synaptosomes | 1986 |
An antibody to dihydropyridine calcium entry blockers. A comparison with the calcium channel receptor in skeletal muscle.
Topics: Antibodies; Antibody Affinity; Antibody Specificity; Antigens; Calcium Channel Blockers; Calcium Channels; Chemical Phenomena; Chemistry; Dihydropyridines; Haptens; Muscles; Nitrendipine; Pyridines; Receptors, Nicotinic | 1986 |
Gonadotropin-releasing hormone-induced Ca2+ transients in single identified gonadotropes require both intracellular Ca2+ mobilization and Ca2+ influx.
Topics: Animals; Calcium; Cells, Cultured; Dihydropyridines; Female; Gonadotropin-Releasing Hormone; Nitrendipine; Pituitary Gland, Anterior; Potassium; Rats; Rats, Inbred Strains | 1988 |
Stimulation of canine cardiac sarcoplasmic reticulum Ca2+ uptake by dihydropyridine Ca2+ antagonists.
Topics: Animals; Ca(2+) Mg(2+)-ATPase; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Calmodulin; Dihydropyridines; Dogs; In Vitro Techniques; Male; Myocardium; Pyridines; Sarcoplasmic Reticulum | 1985 |
Phosphorylation of ventricular sarcolemmal membranes does not alter binding properties of nitrendipine.
Topics: Alamethicin; Animals; Cats; Dihydropyridines; Dose-Response Relationship, Drug; Female; Heart Ventricles; Isoproterenol; Male; Myocardial Contraction; Myocardium; Nifedipine; Nitrendipine; Phosphorylation; Protein Kinases; Pyridines; Sarcolemma; Time Factors | 1985 |
Effects of mercaptans upon dihydropyridine binding sites on transverse tubules isolated from triads of rabbit skeletal muscle.
Topics: Animals; Digoxin; Dihydropyridines; Dithiothreitol; Glutathione; Glutathione Disulfide; Muscles; Nifedipine; Nitrendipine; Ouabain; Pyridines; Rabbits; Sulfhydryl Compounds | 1985 |
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
Topics: Animals; Cats; Collagen; Dihydropyridines; Humans; Kinetics; Male; Mice; Nitrendipine; Platelet Aggregation; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thrombosis | 1988 |
The calcium channel antagonist omega-conotoxin inhibits secretion from peptidergic nerve terminals.
Topics: Animals; Arginine Vasopressin; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Electric Stimulation; In Vitro Techniques; Kinetics; Male; Mollusk Venoms; Nerve Endings; Nicardipine; omega-Conotoxin GVIA; Pituitary Gland, Posterior; Potassium; Rats; Reference Values; Verapamil | 1988 |
Conformation of 1,4-dihydropyridine--planar or boat-like?
Topics: Dihydropyridines; Molecular Conformation; Molecular Structure | 1988 |
Cytochrome P-450-catalyzed dehydrogenation of 1,4-dihydropyridines.
Topics: Algorithms; Animals; Cytochrome P-450 Enzyme System; Dihydropyridines; Humans; Kinetics; Microsomes, Liver; Models, Chemical; Rats; Structure-Activity Relationship | 1988 |
A novel 1,4-dihydropyridine-binding site on mitochondrial membranes from guinea-pig heart, liver and kidney.
Topics: Animals; Binding Sites; Centrifugation, Density Gradient; Dihydropyridines; Diltiazem; Guinea Pigs; Intracellular Membranes; Kidney; Mitochondria; Mitochondria, Heart; Mitochondria, Liver; Nitrendipine; Osmolar Concentration; Subcellular Fractions; Verapamil | 1988 |
Improved delivery through biological membranes. XXX. Synthesis and biological aspects of a 1,4-dihydropyridine based chemical delivery system for brain-sustained delivery of hydroxy CCNU.
Topics: Animals; Brain; Delayed-Action Preparations; Dihydropyridines; Lomustine; Male; Oxidation-Reduction; Pharmaceutical Vehicles; Rats; Rats, Inbred Strains; Solubility | 1987 |
Novel dihydropyridine calcium channel antagonists: structural features which extend duration of action.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Pyridines; Structure-Activity Relationship | 1987 |
Verapamil impairs human neutrophil chemotaxis by a non-calcium-mediated mechanism.
Topics: Calcium; Cell Membrane; Cell Movement; Cell Survival; Chemotaxis, Leukocyte; Cytosol; Dihydropyridines; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pyridines | 1986 |
Quantitative relationships between structure and microsomal oxidation rate of 1,4-dihydropyridines.
Topics: Animals; Antihypertensive Agents; Biotransformation; Dihydropyridines; Dogs; Half-Life; Hypertension; Male; Microsomes, Liver; Molecular Conformation; Oxidation-Reduction; Pyridines; Rats; Rats, Mutant Strains; Structure-Activity Relationship | 1986 |
Effects of calcium antagonists on phencyclidine behaviors.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Drug Interactions; Male; Mice; Motor Activity; Motor Skills; Nifedipine; Phencyclidine; Prazosin; Pyridines; Verapamil | 1986 |
The enantiomers of the dihydropyridine derivative H 160/51 show opposite effects of stimulation and inhibition.
Topics: Animals; Cats; Depression, Chemical; Dihydropyridines; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Muscles; Papillary Muscles; Portal Vein; Pyridines; Stereoisomerism; Stimulation, Chemical | 1986 |
Isomeric composition of N-alkylated protoporphyrins produced by substituted dihydropyridines in vivo and in vitro.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Dihydropyridines; In Vitro Techniques; Kinetics; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Porphyrins; Protoporphyrins; Pyridines; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
The interaction of phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine binding site.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Dihydropyridines; Heart; Kinetics; Male; Nifedipine; Nitrendipine; Pyridines; Rats; Rats, Inbred Strains; Receptors, Drug; Structure-Activity Relationship; Verapamil | 1986 |
Nitrobenzylthioinosine binding in brain: an interspecies study.
Topics: Animals; Brain; Calcium Channel Blockers; Cerebral Cortex; Dihydropyridines; Dogs; Guinea Pigs; Humans; Inosine; Kinetics; Mice; Pyridines; Rats; Rats, Inbred Strains; Species Specificity; Thioinosine | 1985 |
Inhibition by dihydropyridine class calcium channel blockers of tumor cell-platelet-endothelial cell interactions in vitro and metastasis in vivo.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Adhesion; Cell Communication; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Endothelium; Female; Male; Mice; Neoplasm Metastasis; Platelet Aggregation; Pyridines; Rats | 1985 |
Biological activity of 1,4-dihydropyridine derivatives.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antineoplastic Agents; Bacteria; Dihydropyridines; Drug Evaluation, Preclinical; Fungi; Leukemia L1210; Leukemia P388; Melanoma; Mice; Pyridines; Species Specificity; Structure-Activity Relationship | 1985 |
New 1,4-dihydropyridine derivatives with potent and long-lasting hypotensive effect.
Topics: Animals; Antihypertensive Agents; Chemical Phenomena; Chemistry; Dihydropyridines; Male; Piperazines; Pyridines; Rats; Rats, Inbred SHR | 1985 |
Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists.
Topics: Animals; Binding Sites; Cattle; Dihydropyridines; Electrophysiology; Heart Conduction System; Ion Channels; Membrane Potentials; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Purkinje Fibers; Pyridines; Verapamil | 1984 |
Comparative structure-activity relationships for dihydropyridines as inhibitors of [3H]-nitrendipine binding vs cyclic nucleotide phosphodiesterases.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Binding, Competitive; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Kinetics; Male; Myocardium; Nifedipine; Nitrendipine; Pyridines; Rats; Structure-Activity Relationship | 1984 |
(-)-3H-desmethoxyverapamil labelling of putative calcium channels in brain: autoradiographic distribution and allosteric coupling to 1,4-dihydropyridine and diltiazem binding sites.
Topics: Animals; Autoradiography; Benzazepines; Binding Sites; Brain; Dihydropyridines; Diltiazem; Guinea Pigs; Hippocampus; In Vitro Techniques; Ion Channels; Kinetics; Membranes; Pyridines; Stereoisomerism; Verapamil | 1984 |
Cellular calcium metabolism: activation and antagonism.
Topics: Allosteric Regulation; Asthma; Binding Sites; Calcium; Calcium Channel Blockers; Cell Membrane; Chemical Phenomena; Chemistry; Dihydropyridines; Humans; Ion Channels; Muscle, Smooth; Phospholipids; Pyridines | 1984 |
The identification of cytoplasmic membrane calcium-entry channels by ligand-binding studies.
Topics: Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Ion Channels; Metalloproteins; Pyridines; Receptors, Drug | 1984 |
[Therapy of acute poisoning with orthograde intestinal lavage].
Topics: Amitriptyline; Barbiturates; Diazepam; Dihydropyridines; Glyburide; Humans; Intestines; Mushroom Poisoning; Phenobarbital; Poisoning; Posture; Pyridines; Suicide, Attempted; Therapeutic Irrigation | 1983 |
Molecular properties of the slow inward calcium channel. Molecular weight determinations by radiation inactivation and covalent affinity labeling.
Topics: Affinity Labels; Animals; Calcium; Dihydropyridines; Guinea Pigs; Ion Channels; Methods; Molecular Weight; Muscles; Nifedipine; Nitrendipine; Pyridines | 1983 |
Temperature-dependent regulation of d-cis-[3H]diltiazem binding to Ca2+ channels by 1,4-dihydropyridine channel agonists and antagonists.
Topics: Animals; Benzazepines; Calcium; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Guinea Pigs; Ion Channels; Kinetics; Microsomes; Muscles; Pyridines; Stereoisomerism; Structure-Activity Relationship; Temperature | 1983 |
Diazepam-stimulated increases in the synaptosomal uptake of 45Ca2+: reversal by dihydropyridine calcium channel antagonists.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Chloride; Calcium Radioisotopes; Cerebral Cortex; Diazepam; Dihydropyridines; In Vitro Techniques; Male; Nifedipine; Nitrendipine; Pyridines; Rats; Synaptosomes | 1984 |
Improved delivery through biological membranes. 13. Brain-specific delivery of dopamine with a dihydropyridine in equilibrium with pyridinium salt type redox delivery system.
Topics: Animals; Blood-Brain Barrier; Dihydropyridines; Dopamine; Female; Half-Life; Male; Oxidation-Reduction; Pituitary Gland, Anterior; Prolactin; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred Strains | 1983 |
Short-term regulation of neuronal calcium channels by depolarization.
Topics: Animals; Blotting, Northern; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Down-Regulation; Homeostasis; Ion Channel Gating; Isradipine; Membrane Potentials; Membrane Proteins; Models, Biological; N-Methylscopolamine; Neurons; Potassium; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives; Up-Regulation | 1995 |
Glucocorticoid actions on synaptic plasma membranes: modulation of dihydropyridine-sensitive calcium channels.
Topics: Adenosine Triphosphate; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Membrane; Cerebral Cortex; Cyclic AMP; Dihydropyridines; Glucocorticoids; Isradipine; Kinetics; Male; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Steroids; Synapses; Synaptosomes | 1995 |
Biochemical characterization of ethanol actions on dihydropyridine-sensitive calcium channels in brain synaptosomes.
Topics: Adenosine Triphosphate; Alcoholism; Animals; Binding Sites; Brain; Calcium Channel Blockers; Calcium Channels; Cyclic AMP; Dihydropyridines; Ethanol; Isradipine; Magnesium; Male; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Synaptosomes; Tritium | 1995 |
Cytokinin stimulates dihydropyridine-sensitive calcium uptake in moss protoplasts.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Biological Transport; Calcium; Calcium Channels; Cell Differentiation; Cells, Cultured; Dihydropyridines; In Vitro Techniques; Ion Channel Gating; Plant Cells; Plant Growth Regulators; Plant Physiological Phenomena; Potassium | 1993 |
"Stimulation of dihydropyridine-sensitive Ca2+ influx in cultured myoblasts by 1,25(OH)2-vitamin D3".
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Calcitriol; Calcium Channels; Cells, Cultured; Chick Embryo; Dihydropyridines; Egtazic Acid; Muscles; Nifedipine; Rats; Rats, Wistar | 1993 |
Dihydropyridine-sensitive initial component of the ANG II-induced Ca2+ response in rat adrenal glomerulosa cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Calcium; Calcium Channels, L-Type; Dihydropyridines; Female; Manganese; Membrane Potentials; Muscle Proteins; Nifedipine; Potassium; Rats; Rats, Wistar; Zona Glomerulosa | 1994 |
Ruthenium red inhibits selectively chromaffin cell calcium channels.
Topics: Animals; Calcium Channel Blockers; Cattle; Cell Membrane; Dihydropyridines; Enterochromaffin Cells; Iodine Radioisotopes; Nitrendipine; Norepinephrine; omega-Conotoxin GVIA; Peptides; Ruthenium Red; Tritium | 1994 |
Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Calcium Channels; Calcium Channels, L-Type; Cloning, Molecular; Cytoplasm; Dihydropyridines; Epitopes; Molecular Sequence Data; Muscle Proteins; omega-Conotoxin GVIA; Peptides; Rabbits; Rats; Recombinant Fusion Proteins; Sequence Analysis | 1994 |
Modulators of calcium and potassium channels: their effects on endothelin-1 binding to cardiac membranes.
Topics: Animals; Benzopyrans; Calcium Channels; Cromakalim; Dihydropyridines; Endothelins; Heart; In Vitro Techniques; Male; Membranes; Myocardium; Nifedipine; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley | 1993 |
Dose-dependent cardiotoxic effect of amiodarone in cardioplegic solutions correlates with loss of dihydropyridine binding sites: in vitro evidence for a potentially lethal interaction with procaine.
Topics: Amiodarone; Animals; Binding Sites; Calcium; Calcium Channels; Cardioplegic Solutions; Dihydropyridines; Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Heart; Hemodynamics; In Vitro Techniques; Injections, Intravenous; Microscopy, Electron; Myocardial Contraction; Myocardium; Procaine; Receptors, Adrenergic, beta; Swine | 1994 |
Effects of cyclopiazonic acid on phenylephrine-induced contractions in the rabbit ear artery.
Topics: Animals; Arteries; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Charybdotoxin; Dihydropyridines; Ear; Electrophysiology; Endothelium, Vascular; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Phenylephrine; Potassium Channel Blockers; Rabbits; Sarcoplasmic Reticulum; Scorpion Venoms | 1994 |
Left ventricular mechanical consequences of dihydropyridine calcium channel modulation in conscious and anesthetized chronically instrumented dogs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Anesthesia; Anesthetics; Animals; Autonomic Nerve Block; Autonomic Nervous System; Calcium Channels; Consciousness; Diastole; Dihydropyridines; Dogs; Drug Interactions; Halothane; Hemodynamics; Isoflurane; Myocardial Contraction; Nifedipine; Systole; Ventricular Function, Left | 1994 |
Endogenous DHP-sensitive Ca(2+) channels in Pleurodeles oocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcium; Calcium Channels; Dihydropyridines; Membrane Potentials; Mollusk Venoms; Nifedipine; omega-Conotoxin GVIA; Oocytes; Peptides; Pleurodeles | 1994 |
Calcium channel subtypes in cat chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Barium; Calcium Channels; Cats; Cell Membrane Permeability; Cells, Cultured; Dihydropyridines; Female; Ion Channel Gating; Male; Membrane Potentials; Nisoldipine; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides | 1994 |
Inhibition of dihydropyridine-sensitive calcium entry in hypoxic relaxation of airway smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bronchi; Calcium; Calcium Channel Blockers; Carbachol; Dihydropyridines; Female; Hypoxia; Male; Muscle Relaxation; Muscle, Smooth; Nifedipine; Potassium Chloride; Swine | 1995 |
Single-channel properties of four calcium channel types in rat motoneurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium Channels; Dihydropyridines; Hypoglossal Nerve; Motor Neurons; Nerve Tissue Proteins; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Rats; Rats, Sprague-Dawley; Spider Venoms | 1995 |
Modulation of the dihydropyridine-insensitive Ca2+ influx by 8-bromo-guanosine-3':5'-monophosphate, cyclic (8-Br-cGMP) in bovine adrenal chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Bucladesine; Calcium; Calcium Channels; Cattle; Cells, Cultured; Cyclic GMP; Dihydropyridines; Neomycin; Nerve Tissue Proteins; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Potassium Chloride; Second Messenger Systems; Spider Venoms | 1994 |
Single calcium channel behavior in native skeletal muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium Compounds; Cadmium; Cadmium Chloride; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Chlorides; Dihydropyridines; Electrophysiology; Isradipine; Lanthanum; Mice; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Patch-Clamp Techniques | 1995 |
Urinary endothelin and renal vasoconstriction with cyclosporine or FK506 after liver transplantation.
Topics: Cyclosporine; Dihydropyridines; Eicosanoids; Endothelins; Female; Hemodynamics; Humans; Liver Diseases; Liver Transplantation; Male; Middle Aged; Radioimmunoassay; Renal Circulation; Retrospective Studies; Tacrolimus; Vasoconstriction | 1995 |
Voltage-dependent calcium channel beta-subunits in combination with alpha 1 subunits, have a GTPase activating effect to promote the hydrolysis of GTP by G alpha o in rat frontal cortex.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amino Acid Sequence; Animals; Binding Sites; Calcium Channels; Cell Membrane; Dihydropyridines; Enzyme Activation; Frontal Lobe; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Molecular Sequence Data; Peptide Fragments; Rats | 1995 |
Multiple calcium channel subtypes in isolated rat chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Barium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Catecholamines; Cells, Cultured; Dihydropyridines; Female; Ion Channel Gating; Ion Transport; Male; Membrane Potentials; omega-Agatoxin IVA; omega-Conotoxin GVIA; omega-Conotoxins; Patch-Clamp Techniques; Peptides; Rats; Species Specificity; Spider Venoms | 1995 |
Novel 2-amino-1,4-dihydropyridine calcium antagonists. I. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having nitroxy-alkoxycarbonyl groups at 3- and/or 5-position.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Hypertension; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred SHR; Structure-Activity Relationship | 1995 |
Novel 2-amino-1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having N,N-dialkylaminoalkoxycarbonyl groups at 3- and/or 5-position.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Hypertension; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred SHR; Structure-Activity Relationship | 1995 |
N-alkylated 1,4-dihydropyridines: new agents to overcome multidrug resistance.
Topics: Alkylation; Animals; Chemical Phenomena; Chemistry, Physical; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Leukemia P388; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; Verapamil; Vincristine | 1995 |
Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. II. Modulation of high-voltage-activated calcium currents.
Topics: Animals; Anticonvulsants; Calcium Channels; Carbamazepine; Cell Separation; Cerebral Cortex; Corpus Striatum; Dihydropyridines; Glutamates; Male; Neural Pathways; Nifedipine; Oxcarbazepine; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Presynaptic; Synaptic Transmission | 1995 |
1,4-Dihydropyridine binding sites in moss plasma membranes. Properties of receptors for a calcium channel antagonist.
Topics: Azides; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cations, Divalent; Cell Membrane; Cytokinins; Dihydropyridines; Hydrogen-Ion Concentration; Kinetics; Oxidation-Reduction; Plant Development; Plants; Sulfhydryl Reagents; Temperature | 1995 |
Regulation of dihydropyridine-sensitive Ca++ channels during opioid tolerance and supersensitivity in rats.
Topics: Analgesics, Opioid; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Drug Synergism; Drug Tolerance; Ion Transport; Male; Nimodipine; Rats; Rats, Wistar; Sufentanil | 1995 |
Dihydropyridine-like effects of amiodarone and desethylamiodarone on thyrotropin secretion and intracellular calcium concentration in rat pituitary.
Topics: Amiodarone; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Drug Synergism; Male; Nifedipine; Peptide Fragments; Pituitary Gland; Protein Precursors; Rats; Rats, Wistar; Thyrotropin; Thyrotropin-Releasing Hormone; Triiodothyronine | 1995 |
Molecular determinants of cardiac Ca2+ channel pharmacology. Subunit requirement for the high affinity and allosteric regulation of dihydropyridine binding.
Topics: Allosteric Regulation; Animals; Calcium Channels; Cell Line; Dihydropyridines; Diltiazem; DNA, Complementary; Female; Kinetics; Ligands; Molecular Structure; Muscle, Skeletal; Myocardium; Nisoldipine; Oocytes; Protein Conformation; Rabbits; Transfection; Xenopus | 1995 |
Block of non-L-, non-N-type Ca2+ channels in rat insulinoma RINm5F cells by omega-agatoxin IVA and omega-conotoxin MVIIC.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electric Stimulation; Insulinoma; Kinetics; Nifedipine; omega-Agatoxin IVA; omega-Conotoxins; Pancreatic Neoplasms; Peptides; Rats; Spider Venoms; Tumor Cells, Cultured | 1995 |
Coordination of Ca2+ by the pore region glutamates is essential for high-affinity dihydropyridine binding to the cardiac Ca2+ channel alpha 1 subunit.
Topics: Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Benzylisoquinolines; Binding Sites; Calcium Channel Blockers; Calcium Channels; Carps; Cell Line; Cell Membrane; Chlorocebus aethiops; Dihydropyridines; DNA Primers; Female; Kidney; Kinetics; Macromolecular Substances; Membrane Potentials; Models, Structural; Molecular Sequence Data; Muscle, Skeletal; Mutagenesis, Site-Directed; Myocardium; Oocytes; Protein Structure, Secondary; Recombinant Proteins; Transfection; Xenopus laevis | 1995 |
Calcium binding in the pore of L-type calcium channels modulates high affinity dihydropyridine binding.
Topics: Amino Acid Sequence; Barium; Binding Sites; Cadmium; Calcium; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Glutamic Acid; Ion Channel Gating; Membranes; Models, Biological; Models, Chemical; Molecular Sequence Data; Mutation; Protein Conformation; Radioligand Assay | 1995 |
Effects of tetrandrine on left ventricle hypertrophy in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Alkaloids; Animals; Antihypertensive Agents; Benzylisoquinolines; Binding, Competitive; Blood Pressure; Body Weight; Calcium; Desoxycorticosterone; Dihydropyridines; Disease Models, Animal; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Isradipine; Male; Mitochondria, Heart; Organ Size; Radioligand Assay; Random Allocation; Rats; Rats, Sprague-Dawley | 1995 |
[Comment on the information by the Federal Drug and Medical Products Institute on "calcium channel blockers of the 1,4-dihydropyridine class"].
Topics: Calcium Channel Blockers; Coronary Disease; Delayed-Action Preparations; Dihydropyridines; Drug Approval; Germany; Humans; Hypertension; Structure-Activity Relationship | 1995 |
Identification of a novel calcium antagonist binding site in rat brain by SR 33557.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding Sites; Calcium Channel Blockers; Cations, Divalent; Cations, Monovalent; Cecum; Cerebral Cortex; Dihydropyridines; Female; Guinea Pigs; Indolizines; Male; Muscle Contraction; Muscle, Smooth; Phenethylamines; Rats; Rats, Sprague-Dawley | 1993 |
Effects of nifedipine and Bay-K-8644 on the release of catecholamines from the dog adrenal gland in response to splanchnic nerve stimulation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Glands; Anesthesia; Animals; Calcium Channels; Dihydropyridines; Dogs; Electric Stimulation; Epinephrine; Female; Male; Nifedipine; Norepinephrine; Sensitivity and Specificity; Splanchnic Nerves | 1993 |
Two high-voltage-activated, dihydropyridine-sensitive Ca2+ channel currents with distinct electrophysiological and pharmacological properties in cultured rat aortic myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta; Barium; Calcium Channels; Cell Membrane Permeability; Cells, Cultured; Dihydropyridines; Electric Conductivity; Electrophysiology; Male; Muscle, Smooth, Vascular; Nicardipine; Rats; Rats, Wistar | 1993 |
Blockade by funnel web toxin of a calcium current in the intermediate pituitary of the rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cadmium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Ion Channel Gating; Male; Mollusk Venoms; Nickel; Peptides; Pituitary Gland; Polyamines; Rats; Rats, Sprague-Dawley; Spider Venoms | 1993 |
The involvement of dihydropyridine-sensitive calcium channels in phorbol ester-induced luteinizing hormone and growth hormone release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Calcium; Calcium Channels; Dihydropyridines; Female; Growth Hormone; Ion Channel Gating; Isoquinolines; Luteinizing Hormone; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine | 1993 |
1,4-Dihydropyridines containing R-NNO-azoxy moieties.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Structure-Activity Relationship | 1995 |
Differential effects of NGF and BDNF on voltage-gated calcium currents in embryonic basal forebrain neurons.
Topics: Action Potentials; Animals; Brain-Derived Neurotrophic Factor; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Culture Media, Serum-Free; Dihydropyridines; Embryo, Mammalian; Kinetics; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Prosencephalon; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Altered muscle calcium channel binding kinetics in autoimmune motoneuron disease.
Topics: Amyotrophic Lateral Sclerosis; Calcium Channels; Dihydropyridines; Humans; Ion Channel Gating; Motor Neuron Disease; Muscles; Neuromuscular Diseases | 1995 |
Contribution of L- and N-type calcium currents to exocytosis in rat adrenal medullary chromaffin cells.
Topics: Adrenal Medulla; Animals; Cadmium; Calcium Channel Blockers; Calcium Channels; Catecholamines; Cell Membrane; Chromaffin System; Dihydropyridines; Electrophysiology; Exocytosis; Fura-2; In Vitro Techniques; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Rats; Rats, Sprague-Dawley | 1995 |
Cloning and expression of a novel truncated calcium channel from non-excitable cells.
Topics: Acetamides; Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Calcium Channels; Calcium Channels, L-Type; Cell Differentiation; Cloning, Molecular; Dihydropyridines; DNA, Complementary; Leukemia, Erythroblastic, Acute; Mice; Molecular Sequence Data; Muscle Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Tumor Cells, Cultured; Xenopus laevis | 1995 |
Fibroblast growth factor-induced increases in calcium currents in the PC12 pheochromocytoma cell line are tyrosine phosphorylation dependent.
Topics: Animals; Barium; Biological Transport; Calcium; Calcium Channels; Dihydropyridines; Fibroblast Growth Factor 2; Genistein; Isoflavones; Neoplasm Proteins; omega-Conotoxin GVIA; Patch-Clamp Techniques; PC12 Cells; Peptides; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rats; Signal Transduction; Up-Regulation | 1994 |
Regulation of Ca2+ entry in rat aortic smooth muscle cells in primary culture.
Topics: Animals; Aorta; Calcium; Calcium Channels; Calcium Radioisotopes; Cells, Cultured; Dihydropyridines; Endothelins; Enzyme Activation; Fluorescence; Fura-2; Ion Channel Gating; Kinetics; Male; Manganese; Muscle, Smooth, Vascular; Protein Kinases; Rats; Rats, Inbred WKY | 1994 |
Dihydropyridine-sensitive calcium currents in freshly isolated human and monkey retinal pigment epithelial cells.
Topics: Adult; Animals; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Separation; Cells, Cultured; Dihydropyridines; Fetus; Humans; Macaca mulatta; Membrane Potentials; Patch-Clamp Techniques; Pigment Epithelium of Eye | 1995 |
Synthesis and evaluation of a redox chemical delivery system for brain-enhanced dopamine containing an activated carbamate-type ester.
Topics: Acylation; Alkylation; Animals; Brain; Carbamates; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dihydropyridines; Dopamine; Drug Delivery Systems; Drug Stability; Esters; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Motor Activity; Niacin; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1994 |
Effects of funnel web spider toxin on Ca2+ currents in neurohypophysial terminals.
Topics: Alkaloids; Animals; Benzylisoquinolines; Calcium Channel Blockers; Dihydropyridines; Male; Membrane Potentials; Mollusk Venoms; Nerve Endings; omega-Conotoxin GVIA; Peptides; Pituitary Gland, Posterior; Polyamines; Rats; Spider Venoms | 1994 |
Autocrine production of endothelin-1 participates in the glucocorticoid-induced Ca2+ influx into vascular smooth muscle cells.
Topics: Animals; Aorta; Azepines; Biological Transport; Calcium; Carbon Radioisotopes; Cell Line; Dexamethasone; Dihydropyridines; Endothelin Receptor Antagonists; Endothelins; Indoles; Isradipine; Kinetics; Muscle, Smooth, Vascular; Rats; Receptors, Endothelin | 1995 |
Alpha 2-adrenoceptors activate dihydropyridine-sensitive calcium channels via Gi-proteins and protein kinase C in rat portal vein myocytes.
Topics: Animals; Calcium Channels; Dihydropyridines; Enzyme Activation; Oxymetazoline; Phenylephrine; Portal Vein; Prazosin; Protein Kinase C; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Ryanodine | 1994 |
Dual activation of the cardiac Ca2+ channel alpha 1C-subunit and its modulation by the beta-subunit.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chloride Channels; Dihydropyridines; Electric Conductivity; Female; Ion Channel Gating; Kinetics; Macromolecular Substances; Myocardium; Nifedipine; Nisoldipine; Oocytes; Structure-Activity Relationship; Xenopus laevis | 1995 |
Assignment of the human gene for the alpha 1 subunit of the skeletal muscle DHP-sensitive Ca2+ channel (CACNL1A3) to chromosome 1q31-q32.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium Channels; Chromosome Mapping; Chromosomes, Human, Pair 1; Cricetinae; Cricetulus; Dihydropyridines; DNA; Humans; Hybrid Cells; Molecular Sequence Data; Muscles; Rabbits; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid | 1993 |
Complex molecular mechanism for dihydropyridine binding to L-type Ca(2+)-channels as revealed by fluorescence resonance energy transfer.
Topics: Animals; Calcium Channels; Dihydropyridines; Energy Transfer; Fluorescent Dyes; Kinetics; Ligands; Models, Biological; Muscle, Skeletal; Phenethylamines; Rabbits; Solvents; Spectrometry, Fluorescence | 1994 |
Calcium channels: the beta-subunit increases the affinity of dihydropyridine and Ca2+ binding sites of the alpha 1-subunit.
Topics: Animals; Binding Sites; Calcium; Calcium Channels; Cell Line; Dihydropyridines; DNA, Complementary; Gene Expression; Kinetics; Myocardium; Transfection | 1994 |
Mechanisms of vasoconstriction induced by endothelin-1 in smooth muscle of rabbit mesenteric artery.
Topics: Animals; Calcium; Calcium Channels; Contractile Proteins; Dihydropyridines; Endothelins; GTP-Binding Proteins; In Vitro Techniques; Ion Channel Gating; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Myosins; Phosphorylation; Protein Kinase C; Rabbits; Receptors, Endothelin; Vasoconstriction | 1994 |
In vivo reversal of multidrug resistance by two new dihydropyridine derivatives, S16317 and S16324.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Calcium Channels; Colonic Neoplasms; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Drug Synergism; Felodipine; Female; Humans; Leukemia P388; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Tumor Cells, Cultured; Vincristine | 1994 |
Dihydropyridine ligands influence the evoked release of oxytocin and vasopressin dependent on stimulation conditions.
Topics: Animals; Calcium Channel Agonists; Calcium Channel Blockers; Dihydropyridines; Electric Stimulation; Electrophysiology; Female; Ligands; Nicotinic Acids; Nitrendipine; Oxadiazoles; Oxytocin; Pituitary Gland, Posterior; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Vasopressins | 1994 |
The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebellum; Cyclic AMP; Cycloleucine; Dihydropyridines; Glutamic Acid; GTP-Binding Proteins; Mice; Neurotoxins; Nifedipine; Pertussis Toxin; Protein Kinases; Receptors, Metabotropic Glutamate; Second Messenger Systems; Up-Regulation; Virulence Factors, Bordetella | 1994 |
Canine myocardial dihydropyridine binding sites: a positron emission tomographic study with the calcium channel inhibitor 11C-S11568.
Topics: Animals; Binding Sites; Blood Pressure; Calcium Channel Blockers; Carbon Radioisotopes; Coronary Vessels; Dihydropyridines; Dogs; Female; Heart; Heart Rate; Isradipine; Myocardium; Tomography, Emission-Computed | 1994 |
L-type calcium channels: asymmetrical intramembrane binding domain revealed by variable length, permanently charged 1,4-dihydropyridines.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrochemistry; Guinea Pigs; Heart Ventricles; Lipid Bilayers; Ventricular Function | 1994 |
Mechanism of Ca(2+)-sensitive inactivation of L-type Ca2+ channels.
Topics: Animals; Barium; Calcium; Calcium Channels; Cells, Cultured; Dihydropyridines; Heart; Ion Channel Gating; Mathematics; Membrane Potentials; Models, Biological; Probability; Rats; Signal Transduction; Time Factors | 1994 |
Double-pulse facilitation of smooth muscle alpha 1-subunit Ca2+ channels expressed in CHO cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Carrier Proteins; CHO Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Dihydropyridines; DNA, Complementary; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine Diphosphate; Intracellular Signaling Peptides and Proteins; Ion Channel Gating; Membrane Potentials; Muscle, Smooth; Phosphorylation; Protein Kinase C; Thionucleotides | 1994 |
Modulation of L-type Ca2+ channels in clonal rat pituitary cells by membrane depolarization.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line; Dihydropyridines; Down-Regulation; Isradipine; Kinetics; Membrane Potentials; Pituitary Gland, Anterior; Rats | 1994 |
Fluoride reversibly blocks HVA calcium current in mammalian thalamic neurones.
Topics: Animals; Cadmium; Calcium; Calcium Channels; Cells, Cultured; Cesium; Dihydropyridines; Electric Stimulation; Fluorides; Ion Channel Gating; Membrane Potentials; Neurons; Rats; Rats, Wistar; Thalamus | 1994 |
Reevaluation of Ca2+ channel types and their modulation in bullfrog sympathetic neurons.
Topics: Animals; Barium; Calcium Channels; Dihydropyridines; Electric Conductivity; Ganglia, Sympathetic; Membrane Potentials; Neurons; Norepinephrine; omega-Conotoxin GVIA; Peptides; Rana catesbeiana | 1994 |
Decreased density of binding sites for the Ca2+ channel antagonist [3H]isradipine after denervation of rat vas deferens.
Topics: Animals; Binding Sites; Calcium Channels; Denervation; Dihydropyridines; Isradipine; Male; Muscle Contraction; Potassium Chloride; Rats; Rats, Wistar; Vas Deferens | 1994 |
Erythrocyte membrane calcium transport in patients with primary hyperparathyroidism.
Topics: Biological Transport; Ca(2+) Mg(2+)-ATPase; Calcium; Dihydropyridines; Erythrocyte Membrane; Female; Humans; Hyperparathyroidism; Male; Middle Aged; Nitrendipine; Strontium | 1994 |
Blockers of Ca2+ channels in the plasmalemma of perfused Characeae cells.
Topics: Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Chlorophyta; Dihydropyridines; Membrane Potentials; Nifedipine; Nitrendipine; Perfusion; Pyridines | 1994 |
Temporal differences in the induction of dihydropyridine receptor subunits and ryanodine receptors during skeletal muscle development.
Topics: Animals; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Dihydropyridines; Gene Expression Regulation; Muscle Development; Muscle Proteins; Muscles; Protein Conformation; Rats; RNA, Messenger; Ryanodine; Ryanodine Receptor Calcium Release Channel; Time Factors | 1994 |
Increased 1,4-dihydropyridine binding sites in serum-stimulated cardiomyocyte hypertrophy.
Topics: Animals; Binding Sites; Blood; Calcium; Calcium Channels; Cardiomegaly; Cells, Cultured; Dihydropyridines; In Vitro Techniques; Ion Channel Gating; Myocardium; Rats; Rats, Sprague-Dawley | 1994 |
Protein kinase C-mediated regulation of L-type Ca channels from skeletal muscle requires phosphorylation of the alpha 1 subunit.
Topics: Animals; Brain; Calcium Channels; Cell Membrane; Chickens; Dihydropyridines; Liposomes; Macromolecular Substances; Muscles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Rabbits | 1994 |
Cloning and functional expression of a neuronal calcium channel beta subunit from house fly (Musca domestica).
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Calcium Channels; Cloning, Molecular; Dihydropyridines; Diptera; DNA Primers; Electric Conductivity; Larva; Molecular Sequence Data; Nerve Tissue Proteins; Recombinant Proteins; Sequence Homology, Amino Acid; Solubility | 1994 |
Dihydropyridine ligand binding decreases earlier in adolescent than in infant swine after global cerebral ischemia.
Topics: Aging; Animals; Blood Pressure; Brain Ischemia; Calcium Channels; Caudate Nucleus; Cerebral Cortex; Dihydropyridines; Hippocampus; Isradipine; Ligands; Membrane Proteins; Nitrendipine; Protein Binding; Swine; Synaptosomes; Time Factors | 1994 |
Ryanodine and dihydropyridine binding patterns and ryanodine receptor mRNA levels in myopathic hamster heart.
Topics: Animals; Calcium; Calcium Channels; Cardiomyopathies; Cricetinae; Dihydropyridines; Doxorubicin; Electrophysiology; Isradipine; Membrane Proteins; Muscle Proteins; Myocardium; RNA, Messenger; Ryanodine; Ryanodine Receptor Calcium Release Channel | 1994 |
Heterologous desensitization and reduced G protein ADP-ribosylation following exposure to alpha 2-adrenoceptor and muscarinic receptor agonists.
Topics: Adenosine Diphosphate Ribose; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Calcium; Calcium Channels; Cells, Cultured; Dihydropyridines; Ganglia, Spinal; GTP-Binding Proteins; Parasympathomimetics; Pertussis Toxin; Receptors, Muscarinic; Spinal Cord; Virulence Factors, Bordetella | 1993 |
In-vivo binding of (+)-[3H]PN 200-110 to peripheral tissues and brain of spontaneously hypertensive rats: effect of lacidipine.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Aorta, Thoracic; Binding Sites; Brain; Calcium Channel Blockers; Cerebral Cortex; Dihydropyridines; Dose-Response Relationship, Drug; Drug Interactions; Heart; Ileum; Injections, Intravenous; Isradipine; Male; Myocardium; Rats; Rats, Inbred SHR; Tritium; Urinary Bladder | 1993 |
Taking the beta test.
Topics: Animals; Binding Sites; Calcium; Calcium Channels; Dihydropyridines; Ion Channel Gating; Myocardium; Oocytes; Xenopus | 1994 |
Differential effects of non-peptidic tachykinin receptor antagonists on Ca2+ channels.
Topics: Animals; Calcium Channels; Dihydropyridines; In Vitro Techniques; Isradipine; Muscles; Rats; Receptors, Tachykinin; Verapamil | 1994 |
Voltage-dependent Ca2+ channels in resistance arteries from spontaneously hypertensive rats.
Topics: Animals; Arteries; Blood Pressure; Body Weight; Calcium Channels; Dihydropyridines; Electrophysiology; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance | 1993 |
Voltage dependent ionic currents in frog cultured skeletal myocytes.
Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Dihydropyridines; Electric Conductivity; Embryo, Nonmammalian; Kinetics; Membrane Potentials; Muscles; Potassium; Potassium Channels; Rana temporaria; Sodium; Sodium Channels; Tetrodotoxin | 1993 |
Voltage-operated calcium channels in fresh and cultured rat retinal pigment epithelial cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Membrane Potentials; omega-Conotoxin GVIA; Peptides; Pigment Epithelium of Eye; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Retinal Degeneration | 1993 |
T-type Ca2+ channels are required for adrenocorticotropin-stimulated cortisol production by bovine adrenal zona fasciculata cells.
Topics: Adrenocorticotropic Hormone; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cattle; Cells, Cultured; Cyclic AMP; Dihydropyridines; Hydrocortisone; Insulin-Like Growth Factor I; Male; Penfluridol; Pimozide; Signal Transduction; Zona Fasciculata | 1993 |
A homologous series of permanently charged 1,4-dihydropyridines: novel probes designed to localize drug binding sites on ion channels.
Topics: Animals; Binding Sites; Calcium Channels; Chemical Phenomena; Chemistry, Physical; Dihydropyridines; Electrochemistry; Guinea Pigs; Molecular Structure; Myocardium; Rats; Structure-Activity Relationship | 1993 |
Calcium channel subtypes controlling serotonin release from human small cell lung carcinoma cell lines.
Topics: Autoantibodies; Base Sequence; Calcium Channel Blockers; Calcium Channels; Calcium-Transporting ATPases; Carcinoma, Small Cell; Dihydropyridines; DNA Primers; Fura-2; Humans; Ionomycin; Lambert-Eaton Myasthenic Syndrome; Lung Neoplasms; Molecular Sequence Data; omega-Conotoxin GVIA; Peptides; Potassium Chloride; Serotonin; Terpenes; Thapsigargin; Tritium; Tumor Cells, Cultured | 1993 |
Effect of periodontal treatment on gingival overgrowth among cyclosporine A-treated renal transplant recipients.
Topics: Adult; Cyclosporine; Dihydropyridines; Female; Gingival Hyperplasia; Gingivectomy; Humans; Kidney Transplantation; Male; Periodontitis; Risk Factors | 1993 |
Hemodynamic and electrophysiologic effects of first- and second-generation calcium antagonists.
Topics: Amlodipine; Calcium Channel Blockers; Cardiac Output; Dihydropyridines; Electrophysiology; Female; Heart Failure; Heart Rate; Hemodynamics; Humans; Hypertension; Male; Myocardial Contraction; Myocardial Ischemia; Ventricular Function, Left | 1994 |
Insect calcium channels. Molecular cloning of an alpha 1-subunit from housefly (Musca domestica) muscle.
Topics: Amino Acid Sequence; Animals; Calcium Channels; Cloning, Molecular; Dihydropyridines; DNA, Complementary; Gene Expression; Houseflies; In Situ Hybridization; Larva; Molecular Sequence Data; Muscles; RNA, Messenger; Sequence Analysis; Sequence Homology; Tissue Distribution | 1994 |
Concurrent nimodipine attenuates the withdrawal signs and the increase of cerebral dihydropyridine binding after chronic morphine treatment in rats.
Topics: Animals; Brain; Dihydropyridines; Male; Morphine; Morphine Dependence; Motor Activity; Nimodipine; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1993 |
Isolation, identification and synthesis of an endogenous arachidonic amide that inhibits calcium channel antagonist 1,4-dihydropyridine binding.
Topics: Animals; Arachidonic Acids; Calcium Channel Blockers; Cattle; Cerebral Cortex; Chemical Fractionation; Chromatography, High Pressure Liquid; Dihydropyridines; Dose-Response Relationship, Drug; Endocannabinoids; Heart Ventricles; Magnetic Resonance Spectroscopy; Mass Spectrometry; Polyunsaturated Alkamides; Rats | 1993 |
The effect of 1,4-dihydropyridine and 1,4-dihydroindeno[1,2-b]pyridine derivatives on glutathione S-transferase activity in vitro.
Topics: Animals; Cattle; Dihydropyridines; Glutathione Transferase; Liver; Pyridines | 1993 |
Synthesis and antihypertensive activities of new 1,4-dihydropyridine derivatives containing nitrooxyalkylester moieties at the 3- and 5-positions.
Topics: Animals; Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Dihydropyridines; Dogs; Female; Heart Rate; Magnetic Resonance Spectroscopy; Male; Spectrophotometry, Infrared; Structure-Activity Relationship | 1993 |
Structure-activity study of antihypertensive 1,4-dihydropyridine derivatives having nitrooxyalkyl moieties at the 3 and 5 positions.
Topics: Animals; Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Chromatography; Dihydropyridines; Dogs; Female; Heart Rate; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Spectrophotometry, Infrared; Structure-Activity Relationship | 1993 |
Activation of gastric mucosal calcium channels by epidermal growth factor.
Topics: Animals; Calcium; Calcium Channels; Calcium Radioisotopes; Chromatography, Affinity; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Gastric Mucosa; In Vitro Techniques; Isradipine; Male; Phosphorylation; Rats; Rats, Sprague-Dawley; Tritium | 1993 |
Dihydropyridine binding and Ca(2+)-channel characterization in clonal calcitonin-secreting cells.
Topics: Alkaloids; Animals; Barium; Benzylisoquinolines; Binding, Competitive; Calcitonin; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line; Cell Membrane; Dihydropyridines; Electric Conductivity; Kinetics; Microelectrodes; Rats; Subcellular Fractions | 1993 |
Imaging terminals of Aplysia sensory neurons demonstrates role of enhanced Ca2+ influx in presynaptic facilitation.
Topics: Action Potentials; Animals; Aplysia; Calcium; Calcium Channels; Dihydropyridines; Motor Neurons; Neuronal Plasticity; Neurons, Afferent; Nitrendipine; Potassium Channels; Serotonin; Synapses | 1993 |
Dihydropyridine- and omega-conotoxin-sensitive Ca2+ currents in cerebellar neurons: persistent block of L-type channels by a pertussis toxin-sensitive G-protein.
Topics: Animals; Cadmium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebellum; Dihydropyridines; Electric Conductivity; Evoked Potentials; Gadolinium; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Mice; Neurons; omega-Conotoxins; Peptides, Cyclic; Pertussis Toxin; Time Factors; Virulence Factors, Bordetella | 1993 |
Calcium influx and protein phosphorylation mediate the metabolic stabilization of synaptic acetylcholine receptors in muscle.
Topics: Alkaloids; Animals; Bucladesine; Calcium; Calcium Channels; Cyclic AMP; Dibutyryl Cyclic GMP; Dihydropyridines; Electric Stimulation; Ethers, Cyclic; Kinetics; Male; Marine Toxins; Motor Endplate; Muscle Denervation; Muscles; Okadaic Acid; Organ Culture Techniques; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Staurosporine; Synapses; Tetrodotoxin; Time Factors | 1993 |
Pertussis toxin treatment increases glutamate release and dihydropyridine binding sites in cultured rat cerebellar granule neurons.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Animals; Baclofen; Barium; Binding Sites; Calcium; Calcium Channels; Cells, Cultured; Cerebellum; Cyclic AMP; Dihydropyridines; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamine; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Membrane Potentials; NAD; Neurons; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Virulence Factors, Bordetella | 1993 |
Functional diversity of L-type calcium channels in rat cerebellar neurons.
Topics: Animals; Calcium Channels; Cerebellum; Dihydropyridines; Electrophysiology; Ion Channel Gating; Myocardium; Neurons; Rats | 1993 |
Calcitonin stimulates calcium transport in distal convoluted tubule cells.
Topics: Animals; Biological Transport; Calcitonin; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Cycloheximide; Dihydropyridines; Dose-Response Relationship, Drug; Kidney Tubules, Distal; Membrane Potentials; Mice; Nifedipine; Parathyroid Hormone; Time Factors | 1993 |
Functional expression of a rapidly inactivating neuronal calcium channel.
Topics: Animals; Calcium Channels; Cerebral Cortex; Cloning, Molecular; Dihydropyridines; In Vitro Techniques; Membrane Potentials; Mollusk Venoms; Neurons; Nickel; omega-Agatoxin IVA; omega-Conotoxin GVIA; omega-Conotoxins; Oocytes; Peptides; Peptides, Cyclic; Rabbits; Rats; Skates, Fish; Spider Venoms; Xenopus | 1993 |
PAF and thrombin actions in platelets are selectively affected by a new 1,4-dihydropyridine derivative.
Topics: Animals; Arachidonic Acid; Blood Platelets; Diglycerides; Dihydropyridines; Phosphatidylinositols; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thrombin; Type C Phospholipases | 1993 |
Identification of 1,4-dihydropyridine binding domains within the primary structure of the alpha 1 subunit of the skeletal muscle L-type calcium channel.
Topics: Affinity Labels; Animals; Azides; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Muscle Proteins; Muscles; Peptide Fragments; Photochemistry; Rabbits; Tritium | 1993 |
Activity of dihydrothienopyridine S312 enantiomers on L-type Ca2+ channels in isolated rat aorta and cerebral microvessels.
Topics: Animals; Binding Sites; Brain; Calcium; Calcium Channel Blockers; Dihydropyridines; Male; Muscle, Smooth, Vascular; Potassium Chloride; Rats; Rats, Wistar; Stereoisomerism; Vasoconstriction; Vasodilator Agents | 1993 |
Neomycin blocks dihydropyridine-insensitive Ca2+ influx in bovine adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Calcium; Calcium Channel Blockers; Cattle; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Epinephrine; Neomycin; Norepinephrine; Potassium | 1993 |
The beta 1-subunit is essential for modulation by protein kinase C of an human and a non-human L-type Ca2+ channel.
Topics: Animals; Barium; Base Sequence; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; Dihydropyridines; Electric Conductivity; Humans; Molecular Sequence Data; Oligodeoxyribonucleotides; Oocytes; Protein Kinase C; Rabbits; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Xenopus | 1995 |
Effects of cerebral ischemia on N-methyl-D-aspartate and dihydropyridine-sensitive calcium currents. An electrophysiological study in the rat hippocampus in situ.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electric Impedance; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Agonists; Hippocampus; Ion Channels; Iontophoresis; Ischemic Attack, Transient; Male; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Reperfusion | 1996 |
Transfer of 1,4-dihydropyridine sensitivity from L-type to class A (BI) calcium channels.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Carps; Dihydropyridines; Ion Channel Gating; Isradipine; Molecular Sequence Data; omega-Agatoxin IVA; omega-Conotoxins; Peptide Fragments; Peptides; Protein Structure, Tertiary; Pyrroles; Rabbits; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Spider Venoms | 1996 |
Characterization of the type of calcium channel primarily regulating GABA exocytosis from brain nerve endings.
Topics: Animals; Brain; Cadmium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Exocytosis; gamma-Aminobutyric Acid; Male; Mice; Mollusk Venoms; Nerve Endings; Nickel; Nitrendipine; omega-Agatoxin IVA; omega-Conotoxins; Peptides; Spider Venoms | 1995 |
cAMP signaling inhibits dihydropyridine-sensitive Ca2+ influx in vascular smooth muscle cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Size; Cells, Cultured; Cyclic AMP; Dihydropyridines; Enzyme Inhibitors; Ion Transport; Isoquinolines; Muscle, Smooth, Vascular; Rats; Rats, Inbred BN; Signal Transduction; Sulfonamides | 1996 |
Molecular determinants of high affinity dihydropyridine binding in L-type calcium channels.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cloning, Molecular; Dihydropyridines; Isradipine; Kinetics; Macromolecular Substances; Models, Structural; Molecular Sequence Data; Muscle, Skeletal; Mutagenesis, Site-Directed; Point Mutation; Protein Structure, Secondary; Rabbits; Radioligand Assay; Recombinant Proteins; Structure-Activity Relationship; Tritium | 1996 |
Calcium store depletion potentiates a phosphodiesterase inhibitor- and dibutyryl cGMP-evoked calcium influx in rat pituitary GH3 cells.
Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Dibutyryl Cyclic GMP; Dihydropyridines; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Pituitary Gland; Rats; Terpenes; Thapsigargin | 1996 |
Actions of 1,4-dihydropyridines in isolated mesenteric vascular beds.
Topics: Animals; Arginine; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Male; Mesenteric Arteries; Nifedipine; Nitrendipine; Nitric Oxide; Nitroarginine; Vasodilation | 1995 |
Heart period variability in patients with variant angina.
Topics: Aged; Angina Pectoris, Variant; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Electrocardiography, Ambulatory; Female; Heart Conduction System; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Sympathetic Nervous System | 1996 |
G-protein modulation of neuronal class E (alpha 1E) calcium channel expressed in GH3 cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Carbachol; Cell Line; Dihydropyridines; Electric Conductivity; Gene Expression; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Neurons; omega-Agatoxin IVA; omega-Conotoxin GVIA; omega-Conotoxins; Peptides; Pertussis Toxin; Pituitary Gland, Anterior; Rats; Somatostatin; Spider Venoms; Virulence Factors, Bordetella | 1996 |
Conotoxin-sensitive and conotoxin-resistant Ca2+ currents in fish retinal ganglion cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Agatoxins; Animals; Barium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Dihydropyridines; Goldfish; Membrane Potentials; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Retinal Ganglion Cells; Spider Venoms | 1996 |
A novel hydrophobic omega-conotoxin blocks molluscan dihydropyridine-sensitive calcium channels.
Topics: Amino Acid Sequence; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Lymnaea; Membrane Potentials; Molecular Probes; Molecular Sequence Data; omega-Conotoxins; Peptides | 1996 |
T-type Ca2+ channels and alpha1E expression in spermatogenic cells, and their possible relevance to the sperm acrosome reaction.
Topics: Acrosome; Animals; Base Sequence; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; DNA Primers; Gene Expression; Male; Mice; Molecular Sequence Data; Patch-Clamp Techniques; Polymerase Chain Reaction; Spermatozoa; Testis | 1996 |
G proteins regulate dihydropyridine binding to moss plasma membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Binding Sites; Bryopsida; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; GTP-Binding Proteins; Guanine Nucleotides; Nifedipine | 1996 |
Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors.
Topics: Adenylyl Cyclase Inhibitors; Animals; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Cerebral Cortex; CHO Cells; Cricetinae; Dihydropyridines; Enzyme Inhibitors; Guinea Pigs; Humans; Isradipine; Molecular Structure; Purinergic P1 Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P1; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship | 1996 |
[A new synthesis of 1,4-dihydropyridines: cyclocondensation of aldimines].
Topics: Dihydropyridines; Imines; Indicators and Reagents; Molecular Structure | 1996 |
Depolarization-evoked increases in cytosolic calcium concentration in isolated smooth muscle cells of rat portal vein.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Cadmium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Cytophotometry; Cytosol; Dihydropyridines; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nimodipine; Patch-Clamp Techniques; Portal Vein; Rats; Rats, Sprague-Dawley; Ryanodine; Tetraethylammonium; Tetraethylammonium Compounds | 1996 |
Activation of nucleotide receptors inhibits high-threshold calcium currents in NG108-15 neuronal hybrid cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine; Adenylyl Cyclases; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Hybrid Cells; Mice; Mollusk Venoms; Neuroblastoma; Neurons; Nifedipine; omega-Conotoxin GVIA; Peptides; Pertussis Toxin; Rats; Receptors, Cell Surface; Virulence Factors, Bordetella | 1996 |
Lipofuscin-like pigments by autoxidation of polyunsaturated fatty acids in the presence of amine neurotransmitters: the role of malondialdehyde.
Topics: Arachidonic Acid; Biogenic Monoamines; Chromatography, High Pressure Liquid; Dihydropyridines; Fluorescent Dyes; Lipid Peroxidation; Lipofuscin; Malondialdehyde; Neurotransmitter Agents | 1996 |
Calcium channel blockers. Lessons learned from MIDAS and other clinical trials.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arteriosclerosis; Calcium Channel Blockers; Cardiovascular Diseases; Clinical Trials as Topic; Confounding Factors, Epidemiologic; Dihydropyridines; Humans; Hypertension | 1996 |
Role of tyrosine kinase on Ca2+ entry and refilling of agonist-sensitive Ca2+ stores in vascular smooth muscles.
Topics: Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Dihydropyridines; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Genistein; Imidazoles; Isoflavones; Mesenteric Arteries; Muscle, Smooth, Vascular; Phenylephrine; Potassium; Protein-Tyrosine Kinases; Vasoconstrictor Agents | 1996 |
Pharmacological analysis of voltage-dependent potassium currents in cultured skeletal myocytes of the frog Rana temporaria.
Topics: 4-Aminopyridine; Animals; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Electric Conductivity; Embryo, Nonmammalian; Membrane Potentials; Muscle, Skeletal; Nifedipine; Patch-Clamp Techniques; Potassium Channels; Quinidine; Rana temporaria; Time Factors; Verapamil | 1995 |
Helothermine, a lizard venom toxin, inhibits calcium current in cerebellar granules.
Topics: Animals; Calcium Channel Blockers; Cerebellum; Dihydropyridines; Lizards; Mollusk Venoms; Neurons; Neurotoxins; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Spider Venoms; Venoms | 1996 |
The effect of oxygen free radicals on calcium current and dihydropyridine binding sites in guinea-pig ventricular myocytes.
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophysiology; Free Radicals; Fumarates; Guinea Pigs; Heart Ventricles; Isradipine; Myocardium; Patch-Clamp Techniques; Ventricular Function | 1996 |
Expression of calcium channel subunits in the normal and diseased human myocardium.
Topics: Amino Acid Sequence; Binding Sites; Calcium Channels; Calcium Channels, L-Type; Cardiomyopathy, Hypertrophic; Dihydropyridines; Humans; Molecular Sequence Data; Myocardium | 1996 |
Dihydropyridine and ryanodine binding in ventricles from rat, trout, dogfish and hagfish.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Dogfish; Female; Hagfishes; Heart Ventricles; Isradipine; Muscle Proteins; Myocardial Contraction; Myocardium; Oncorhynchus mykiss; Rats; Rats, Wistar; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Tritium | 1996 |
The structure of the gene encoding the human skeletal muscle alpha 1 subunit of the dihydropyridine-sensitive L-type calcium channel (CACNL1A3).
Topics: Base Sequence; Calcium Channels; Dihydropyridines; DNA Primers; Humans; Molecular Sequence Data; Muscle, Skeletal | 1996 |
Polar localization of a dihydropyridine receptor on living Fucus zygotes.
Topics: Calcium; Calcium Channels; Calcium Channels, L-Type; Cell Membrane; Cell Polarity; Cytochalasin B; Dihydropyridines; Fluorescent Dyes; Phaeophyceae | 1996 |
Conditional differentiation of heart- and smooth muscle-derived cells transformed by a temperature-sensitive mutant of SV40 T antigen.
Topics: Animals; Antigens, Polyomavirus Transforming; Aorta, Thoracic; Calcium; Calcium Channels; Cell Differentiation; Cell Line; Cell Transformation, Viral; Cells, Cultured; Dihydropyridines; Fluorescent Antibody Technique, Indirect; Heart; Lac Operon; Microscopy, Immunoelectron; Muscle, Smooth; Mutation; Myocardium; Patch-Clamp Techniques; Promoter Regions, Genetic; Rats; Receptors, Thrombin; RNA, Messenger; Thermosensing; Thymidine; Transfection; Tritium | 1996 |
Novel omega-conotoxins block dihydropyridine-insensitive high voltage-activated calcium channels in molluscan neurons.
Topics: Amino Acid Sequence; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; In Vitro Techniques; Lymnaea; Membrane Potentials; Molecular Sequence Data; Mollusk Venoms; Neurons; Nimodipine; omega-Conotoxins; Sequence Homology, Amino Acid; Structure-Activity Relationship | 1996 |
Cyclic AMP-dependent protein kinase but not protein kinase C regulates the cardiac Ca2+ channel through phosphorylation of its alpha 1 subunit.
Topics: Animals; Azides; Calcium; Calcium Channel Blockers; Calcium Channels; Cattle; Cyclic AMP-Dependent Protein Kinases; Dihydropyridines; Heart Ventricles; Membrane Potentials; Membrane Proteins; Molecular Weight; Myocardium; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinase C; Proteolipids; Sarcolemma | 1996 |
Dihydropyridine-sensitive and -insensitive voltage-operated calcium channels participate in the control of glucose-induced insulin release from human pancreatic beta cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adult; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Glucose; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Mollusk Venoms; Nitrendipine; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides | 1996 |
I.v. anaesthetic agents inhibit dihydropyridine binding to L-type voltage-sensitive Ca2+ channels in rat cerebrocortical membranes.
Topics: Anesthetics, Intravenous; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Culture Techniques; Dihydropyridines; Dose-Response Relationship, Drug; Female; Rats; Rats, Wistar | 1996 |
Dihydropyridine block of omega-agatoxin IVA- and omega-conotoxin GVIA-sensitive Ca2+ channels in rat pituitary melanotropic cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Male; Melanophores; Nimodipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Pituitary Gland; Rats; Rats, Wistar; Spider Venoms | 1996 |
Subunit composition is a major determinant in high affinity binding of a Ca2+ channel blocker.
Topics: Aniline Compounds; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cations, Divalent; COS Cells; Dihydropyridines; Isradipine; Kinetics; Macromolecular Substances; Muscle, Skeletal; Stimulation, Chemical; Transfection | 1996 |
Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system.
Topics: Animals; Anticonvulsants; Biotransformation; Brain; Calcium Channel Blockers; Dihydropyridines; Felodipine; Male; Mice; Oxidation-Reduction; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Sodium Chloride | 1996 |
Opioid inhibition of Ca2+ channel subtypes in bovine chromaffin cells: selectivity of action and voltage-dependence.
Topics: Animals; Calcium Channel Blockers; Cattle; Cells, Cultured; Chromaffin Cells; Dihydropyridines; Enkephalin, Methionine; GTP-Binding Proteins; Kinetics; Mollusk Venoms; Naloxone; Narcotic Antagonists; omega-Conotoxins; Patch-Clamp Techniques; Peptides | 1996 |
1,4-Dihydropyridines versus beta-blockers for hypertension: are either safe for the heart?
Topics: Adrenergic beta-Antagonists; Adult; Aged; Calcium Channel Blockers; Coronary Disease; Dihydropyridines; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine; Sympathetic Nervous System | 1996 |
Dihydropyridine-sensitive, voltage-gated Ca2+ channels contribute to the resting intracellular Ca2+ concentration of hippocampal CA1 pyramidal neurons.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Hippocampus; Nimodipine; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 1996 |
1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Dihydropyridines; Female; Guinea Pigs; Heart; Lidoflazine; Male; Myocardial Contraction; Vasodilator Agents | 1996 |
Two amino acid residues in the IIIS5 segment of L-type calcium channels differentially contribute to 1,4-dihydropyridine sensitivity.
Topics: Amino Acid Sequence; Animals; Calcium Channel Blockers; Calcium Channels; Carrier Proteins; Dihydropyridines; Insulin-Like Growth Factor Binding Proteins; Ion Channel Gating; Membrane Glycoproteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Rabbits; Structure-Activity Relationship; Xenopus laevis | 1996 |
The role of voltage-dependent calcium channels in angiotensin-stimulated glomerulosa cells.
Topics: Angiotensin II; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Radioisotopes; Cytoplasm; Dihydropyridines; Diltiazem; Electrophysiology; Inositol 1,4,5-Trisphosphate Receptors; Manganese; Membrane Potentials; Potassium; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Zona Glomerulosa | 1996 |
A new type of Ca-channel modulation by a novel class of 1,4-dihydropyridines.
Topics: Action Potentials; Animals; Aorta; Calcium Channel Agonists; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Heart; In Vitro Techniques; Muscle Contraction; Rabbits | 1997 |
Voltage-gated calcium channel currents in human coronary myocytes. Regulation by cyclic GMP and nitric oxide.
Topics: Adult; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Coronary Vessels; Cyclic GMP; Dihydropyridines; Electric Conductivity; Evoked Potentials; Heart Transplantation; Humans; Ion Channel Gating; Male; Middle Aged; Muscle Tonus; Muscles; Nitric Oxide; Patch-Clamp Techniques; Signal Transduction | 1997 |
Motif III S5 of L-type calcium channels is involved in the dihydropyridine binding site. A combined radioligand binding and electrophysiological study.
Topics: Amino Acid Sequence; Animals; Barium; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Female; Humans; Membrane Potentials; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Point Mutation; Radioligand Assay; Recombinant Fusion Proteins; Xenopus laevis | 1997 |
Meiosis reinitiation of mussel oocytes involves L-type voltage-gated calcium channel.
Topics: Animals; Binding Sites; Bivalvia; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Membrane; Dihydropyridines; Dose-Response Relationship, Drug; Ion Channel Gating; Isradipine; Meiosis; Oocytes; Potassium Chloride; Tritium | 1997 |
Metabolic inhibitors affect the conductance of low voltage-activated calcium channels in brain capillary endothelial cells.
Topics: 2,4-Dinitrophenol; Action Potentials; Amiloride; Animals; Antimetabolites; Brain; Calcium; Calcium Channels; Capillaries; Cell Hypoxia; Cells, Cultured; Charybdotoxin; Dihydropyridines; Endothelium, Vascular; Energy Metabolism; Ion Channel Gating; Ion Transport; Nickel; Patch-Clamp Techniques; Potassium; Potassium Channels; Rats; Sodium Cyanide; Tetrodotoxin | 1996 |
Two stable cell lines for screening of calcium channel blockers.
Topics: Benzimidazoles; Calcium Channel Blockers; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fura-2; Heart; Mibefradil; Muscle, Smooth, Vascular; Myocardium; Nisoldipine; Patch-Clamp Techniques; Polymerase Chain Reaction; Potassium; Structure-Activity Relationship; Tetrahydronaphthalenes; Transfection | 1995 |
Dihydropyridine- and neurotoxin-sensitive and -insensitive calcium currents in acutely dissociated neurons of the rat central amygdala.
Topics: Amygdala; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Female; Neurons; Neurotoxins; Pregnancy; Rats; Rats, Sprague-Dawley; Time Factors | 1997 |
Reconstitution of the skeletal muscle dihydropyridine receptor. Functional interaction among alpha 1, beta, gamma and alpha 2 delta subunits.
Topics: Animals; Calcium Channels; Calcium Channels, L-Type; COS Cells; Dihydropyridines; Gene Expression; Muscle Proteins; Muscle, Skeletal | 1996 |
Pharmacological characterization and autoradiographic localization of dihydropyridine-type calcium channels in the kidney of spontaneously hypertensive rats.
Topics: Animals; Autoradiography; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Kidney; Kinetics; Male; Nicardipine; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1995 |
Reducing extracellular Cl- suppresses dihydropyridine-sensitive Ca2+ currents and synaptic transmission in amphibian photoreceptors.
Topics: Ambystoma; Animals; Calcium Channel Blockers; Chlorides; Dihydropyridines; Evoked Potentials; Glutamic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Light; Necturus; Neurons; Photoreceptor Cells; Synaptic Transmission | 1997 |
Different contributions of L- and Q-type Ca2+ channels to Ca2+ signals and secretion in chromaffin cell subtypes.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cattle; Chromaffin System; Cytosol; Dihydropyridines; Epinephrine; Norepinephrine; omega-Conotoxin GVIA; omega-Conotoxins; Osmolar Concentration; Peptides; Potassium; Signal Transduction | 1997 |
Dihydropyridine-sensitive calcium current mediates neurotransmitter release from retinal bipolar cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Goldfish; In Vitro Techniques; Membrane Potentials; Neurons; Neurotransmitter Agents; Retina | 1993 |
Sympathetic modulation of the effect of nifedipine on myocardial contraction and Ca current in the rat.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atenolol; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Heart Ventricles; Hypertension; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardial Reperfusion; Nifedipine; Patch-Clamp Techniques; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, beta; Sympatholytics; Sympathomimetics; Ventricular Function | 1997 |
Global ischemia increases the density of voltage-dependent calcium channels in porcine cardiac sarcolemma.
Topics: 5'-Nucleotidase; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Heart Ventricles; In Vitro Techniques; Isradipine; Myocardial Ischemia; Myocardium; Sarcolemma; Swine | 1997 |
Venodilator effects of pranidipine, a 1,4-dihydropyridine Ca2+ channel antagonist, in rats: comparison with nifedipine and amlodipine.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Dihydropyridines; Injections, Intravenous; Male; Nifedipine; Rats; Rats, Sprague-Dawley; Venous Pressure | 1997 |
Action and binding of calcium channel blockers on the putative calcium channel of synaptosomal plasma membrane from the electric organ of Narke japonica.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electric Organ; Kinetics; Membrane Potentials; omega-Conotoxin GVIA; Peptides; Skates, Fish; Synaptic Membranes; Synaptosomes | 1993 |
Depolarization and activation of dihydropyridine-sensitive Ca2+ channels stimulate inositol phosphate accumulation in photoreceptor-enriched chick retinal cell cultures.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chick Embryo; Dihydropyridines; Electric Stimulation; Estrenes; Inositol Phosphates; Membrane Potentials; Nifedipine; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phosphodiesterase Inhibitors; Photoreceptor Cells; Potassium; Pyrrolidinones; Type C Phospholipases; Virulence Factors, Bordetella | 1997 |
Characterization of voltage-sensitive calcium channels in growth plate chondrocytes.
Topics: Animals; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chickens; Dihydropyridines; Growth Plate; Ion Transport; Membrane Potentials; Potassium | 1997 |
cAMP-dependent enhancement of dihydropyridine-sensitive calcium channel availability in hippocampal neurons.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cyclic AMP; Dihydropyridines; Hippocampus; Rats; Rats, Sprague-Dawley | 1997 |
Role of dihydropyridine sensitive calcium channels in glucose transport in skeletal muscle.
Topics: Animals; Biological Transport; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electric Stimulation; Glucose; Insulin; Male; Muscle Contraction; Muscle, Skeletal; Nifedipine; Rats; Rats, Sprague-Dawley | 1997 |
Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonists.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding, Competitive; Brain; Calcium; Calcium Channel Blockers; Calmodulin; Cattle; Cyclic Nucleotide Phosphodiesterases, Type 1; Dihydropyridines; Felodipine; Isoenzymes; Molecular Weight; Nicardipine; Phosphodiesterase Inhibitors | 1997 |
L-type calcium channel activation controls the in vivo transduction of the neuralizing signal in the amphibian embryos.
Topics: Aequorin; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Carrier Proteins; Dihydropyridines; Ectoderm; Gastrula; Ion Transport; Nervous System; Nimodipine; Pleurodeles; Proteins; Signal Transduction | 1997 |
Osmo-mechanically sensitive phosphatidylinositol signaling regulates a Ca2+ influx channel in renal epithelial cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Carbamates; Cells, Cultured; Dihydropyridines; Enzyme Inhibitors; Epithelium; In Vitro Techniques; Kidney Cortex; Kinetics; Male; Nifedipine; Phenylcarbamates; Phosphatidylinositols; Rabbits; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Water-Electrolyte Balance | 1997 |
Involvement of both calcium influx and calcium mobilization in growth hormone-induced [Ca2+]i increases in Chinese hamster ovary cells.
Topics: Animals; Calcium; Calcium Channels; CHO Cells; Cricetinae; Dihydropyridines; Growth Hormone; Intracellular Fluid; Patch-Clamp Techniques; Rabbits; Thapsigargin; Verapamil | 1997 |
Mechanisms for stimulation of rat anterior pituitary cells by arginine and other amino acids.
Topics: Adrenocorticotropic Hormone; Amino Acids; Animals; Arginine; Calcium; Calcium Channels; Calcium Channels, L-Type; Cell Membrane; Cells, Cultured; Cytosol; Dihydropyridines; Follicle Stimulating Hormone; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Wistar; Tetrodotoxin; Thyrotropin | 1997 |
Dissection of functional domains of the voltage-dependent Ca2+ channel alpha2delta subunit.
Topics: Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Dihydropyridines; Humans; Isradipine; Kinetics; Protein Biosynthesis; Protein Conformation; Transcription, Genetic; Transfection | 1997 |
Regulation of mouse skeletal muscle L-type Ca2+ channel by activation of the insulin-like growth factor-1 receptor.
Topics: Adenosine Triphosphate; Animals; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Insulin-Like Growth Factor I; Mice; Mice, Inbred C57BL; Molecular Weight; Muscle, Skeletal; Phosphorylation; Protein Kinase C; Receptor, IGF Type 1 | 1997 |
Modulation of the dihydropyridine-sensitive calcium channels in Drosophila by a phospholipase C-mediated pathway.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Diglycerides; Dihydropyridines; Drosophila; Enzyme Inhibitors; Female; Larva; Male; Muscles; Mutation; Protein Kinase C; Type C Phospholipases | 1997 |
Electrochemical generation and reactivity of free radical redox intermediates from ortho- and meta-nitro substituted 1,4-dihydropyridines.
Topics: Animals; Cysteamine; Dihydropyridines; Electrochemistry; Free Radicals; Glutathione; Hydrogen-Ion Concentration; Kinetics; Nitro Compounds; Oxidation-Reduction; Trypanosoma cruzi | 1997 |
Molecular studies on the voltage dependence of dihydropyridine action on L-type Ca2+ channels. Critical involvement of tyrosine residues in motif IIIS6 and IVS6.
Topics: Animals; Barium; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Female; Isoleucine; Membrane Potentials; Mutagenesis, Site-Directed; Myocardium; Oocytes; Point Mutation; Polymerase Chain Reaction; Rabbits; Stereoisomerism; Xenopus laevis | 1997 |
Are calcium antagonists proarrhythmic?
Topics: Arrhythmias, Cardiac; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Heart; Humans; Myocardial Ischemia; Prospective Studies; Risk Factors | 1997 |
Diversity in the renal hemodynamic effects of dihydropyridine calcium blockers in spontaneously hypertensive rats.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Hemodynamics; Infusions, Intravenous; Kidney; Kidney Tubules; Rats; Rats, Inbred SHR | 1997 |
Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: II. Effects on myocyte contractile processes.
Topics: Analysis of Variance; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzazepines; Calcium Channels; Calcium Channels, L-Type; Calcium-Binding Proteins; Calcium-Transporting ATPases; Cardiac Pacing, Artificial; Cell Membrane; Cells, Cultured; Dihydropyridines; Heart Failure; Myocardial Contraction; Myocardium; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System; Sarcoplasmic Reticulum; Sodium-Potassium-Exchanging ATPase; Swine; Tetrazoles; Valine; Valsartan; Ventricular Function, Left | 1997 |
Nine L-type amino acid residues confer full 1,4-dihydropyridine sensitivity to the neuronal calcium channel alpha1A subunit. Role of L-type Met1188.
Topics: Amino Acid Sequence; Amino Acids; Animals; Calcium Channels; Dihydropyridines; Molecular Sequence Data; Mutagenesis; Neurons; Protein Binding; Rabbits; Recombinant Fusion Proteins; Xenopus laevis | 1997 |
Transfer of the high affinity dihydropyridine sensitivity from L-type To non-L-type calcium channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amino Acid Sequence; Calcium Channel Blockers; Calcium Channels; Cell Line; Dihydropyridines; Humans; Isradipine; Molecular Sequence Data; Mutagenesis, Site-Directed | 1997 |
Brain pharmacokinetics and in vivo receptor binding of 1,4-dihydropyridine calcium channel antagonists.
Topics: Animals; Area Under Curve; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Dihydropyridines; Male; Mice; Myocardium; Receptors, Drug | 1997 |
Distribution, splicing and glucocorticoid-induced expression of cardiac alpha 1C and alpha 1D voltage-gated Ca2+ channel mRNAs.
Topics: Amino Acid Sequence; Animals; Calcium Channel Blockers; Calcium Channels; Dexamethasone; Dihydropyridines; Female; Glucocorticoids; Heart; Heart Atria; Heart Ventricles; Membrane Potentials; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; RNA Splicing; RNA, Messenger | 1997 |
Construction of a high-affinity receptor site for dihydropyridine agonists and antagonists by single amino acid substitutions in a non-L-type Ca2+ channel.
Topics: Amino Acid Substitution; Amino Acids; Binding Sites; Calcium Channels; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Humans | 1997 |
Arachidonylethanolamide (anandamide) binds with low affinity to dihydropyridine binding sites in brain membranes.
Topics: Amides; Amidohydrolases; Animals; Arachidonic Acids; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Dihydropyridines; Endocannabinoids; Ethanolamines; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Tosyl Compounds | 1997 |
Voltage-dependent calcium currents in bulbospinal neurons of neonatal rat rostral ventrolateral medulla: modulation by alpha2-adrenergic receptors.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Brimonidine Tartrate; Calcium; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Fluorescent Dyes; Ion Channel Gating; Medulla Oblongata; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Prazosin; Propranolol; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Spider Venoms; Tyrosine 3-Monooxygenase | 1998 |
Formation of a dihydropyridine derivative as a potential cross-link derived from malondialdehyde in physiological systems.
Topics: Cross-Linking Reagents; Dihydropyridines; Lysine; Malondialdehyde; Propylamines | 1998 |
Molecular pharmacology of UK-118, 434-05, a permanently charged amlodipine analog.
Topics: Amlodipine; Binding Sites; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Gene Expression; Humans; Kidney; Membrane Potentials; Muscle, Smooth, Vascular; Myocardium; Structure-Activity Relationship | 1997 |
L-type and dihydropyridine-resistant calcium channel trigger exocytosis with similar efficacy in single rat pancreatic beta cells.
Topics: Animals; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Drug Resistance; Electric Conductivity; Exocytosis; Islets of Langerhans; Nicardipine; Rats; Rats, Sprague-Dawley | 1998 |
Endogenous pacemaker activity of rat tumour somatotrophs.
Topics: Action Potentials; Animals; Antisense Elements (Genetics); Apamin; Barium; Biological Clocks; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Charybdotoxin; Computer Simulation; Cytosol; Dihydropyridines; Growth Hormone; Growth Hormone-Releasing Hormone; Nickel; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Pituitary Neoplasms; Potassium; Rats; Ryanodine Receptor Calcium Release Channel; Sodium; Spider Venoms; Tetraethylammonium; Tetrodotoxin; Tumor Cells, Cultured | 1998 |
Alternative splicing of exons in the alpha1 subunit of the rat testis L-type voltage-dependent calcium channel generates germ line-specific dihydropyridine binding sites.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Exons; Gene Expression Regulation; Male; Molecular Sequence Data; Muscle, Skeletal; Myocardium; Organ Specificity; Rabbits; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sequence Analysis, DNA; Spermatozoa; Testis | 1998 |
L-type calcium channel expression depends on the differentiated state of vascular smooth muscle cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Actins; Animals; Aorta; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Differentiation; Cell Line; Culture Media; Dihydropyridines; Kinetics; Membrane Potentials; Muscle, Smooth, Vascular; Myosin Heavy Chains; Nimodipine; Patch-Clamp Techniques; Rats; Tretinoin | 1998 |
Effects of azelnidipine, a dihydropyridine calcium antagonist, on myocardial stunning in dogs.
Topics: Animals; Atropine; Azetidinecarboxylic Acid; Calcium Channel Blockers; Dihydropyridines; Dogs; Female; Heart; Hemodynamics; Male; Myocardial Contraction; Myocardial Ischemia; Propranolol | 1998 |
Synthesis and radioprotective effects of adamantyl substituted 1,4-dihydropyridine derivatives.
Topics: Adamantane; Animals; Cell Line; Cricetinae; Cricetulus; Dihydropyridines; Magnetic Resonance Spectroscopy; Male; Mice; Radiation-Protective Agents | 1998 |
Voltage-gated calcium channels in Pleurodeles oocytes: classification, modulation and functional roles.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Breeding; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Dihydropyridines; Electric Stimulation; Ion Channel Gating; Ion Transport; Meiosis; Membrane Potentials; Nickel; Nifedipine; omega-Conotoxin GVIA; Oocytes; Peptides; Phosphorylation; Pleurodeles; Progesterone; Protein Processing, Post-Translational; Seasons; Second Messenger Systems | 1998 |
Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents.
Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Calcium Channel Blockers; CHO Cells; Cricetinae; Cytotoxins; Dihydropyridines; Drug Resistance, Multiple; Fibroblasts; Nicardipine; Nimodipine; Nitrendipine; Protein Binding; Verapamil; Vinblastine | 1998 |
Effects of lemildipine, a new calcium channel blocker, on renal microcirculation in SHR.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Glomerular Filtration Rate; Hemodynamics; Kidney; Kidney Tubules, Proximal; Loop of Henle; Male; Microcirculation; Perfusion; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation | 1998 |
Prostaglandins induce calcium influx in human spermatozoa.
Topics: Acrosome; Adult; Alprostadil; Angiotensin II; Atrial Natriuretic Factor; Body Fluids; Calcium; Calcium Channel Blockers; Calcium Channels; Culture Media; Cyclic AMP; Dihydropyridines; Dinoprost; Dinoprostone; Drug Interactions; Endothelin-1; Female; Humans; Infertility, Male; Ion Transport; Male; Ovarian Follicle; Pentoxifylline; Pertussis Toxin; Progesterone; Sperm Capacitation; Sperm-Ovum Interactions; Spermatozoa; Virulence Factors, Bordetella | 1998 |
Ca2+ channel modulation alters halothane-induced depression of ventricular myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Anesthetics, Inhalation; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Drug Synergism; Halothane; Heart Ventricles; Isradipine; Myocardial Contraction; Myocardium; Nifedipine; Rats; Rats, Wistar; Sarcolemma; Verapamil | 1998 |
Life-threatening interaction of mibefradil and beta-blockers with dihydropyridine calcium channel blockers.
Topics: Adrenergic beta-Antagonists; Aged; Benzimidazoles; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dihydropyridines; Drug Interactions; Female; Half-Life; Humans; Mibefradil; Mixed Function Oxygenases; Shock, Cardiogenic; Sinoatrial Node; Tetrahydronaphthalenes | 1998 |
Growth hormone regulates the distribution of L-type calcium channels in rat adipocyte membranes.
Topics: Adipocytes; Adipose Tissue; Animals; Calcium; Calcium Channels; Calcium Channels, L-Type; Cell Membrane; Cells, Cultured; Cytosol; Dihydropyridines; Epididymis; Growth Hormone; Isradipine; Kinetics; Male; Microsomes; Rats; Rats, Inbred Strains | 1998 |
Antioxidant effects of 1,4-dihydropyridine and nitroso aryl derivatives on the Fe+3/ascorbate-stimulated lipid peroxidation in rat brain slices.
Topics: Animals; Antioxidants; Ascorbic Acid; Brain; Calcium Channel Blockers; Dihydropyridines; Ferric Compounds; In Vitro Techniques; Lipid Peroxidation; Nisoldipine; Nitroso Compounds; Oxygen; Rats; Rats, Wistar; Time Factors | 1998 |
Dihydropyridine type calcium channel blocker-induced turbid dialysate in patients undergoing peritoneal dialysis.
Topics: Calcium Channel Blockers; Chylous Ascites; Data Collection; Diagnosis, Differential; Dialysis Solutions; Dihydropyridines; Female; Humans; Japan; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Peritonitis | 1998 |
Combinatorial synthesis and screening of a chemical library of 1,4-dihydropyridine calcium channel blockers.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Dihydropyridines; Drug Evaluation, Preclinical; In Vitro Techniques; Nitrendipine; Radioligand Assay; Rats | 1998 |
Molecular cloning and functional expression of a skeletal muscle dihydropyridine receptor from Rana catesbeiana.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium; Calcium Channels; Calcium Channels, L-Type; Cloning, Molecular; Dihydropyridines; DNA, Complementary; Molecular Sequence Data; Muscle, Skeletal; Polymerase Chain Reaction; Protein Binding; Rabbits; Rana catesbeiana; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus | 1998 |
Passive transfer of Lambert-Eaton myasthenic syndrome induces dihydropyridine sensitivity of ICa in mouse motor nerve terminals.
Topics: Animals; Autoantibodies; Binding, Competitive; Calcium; Calcium Channel Blockers; Dihydropyridines; Immunization, Passive; Lambert-Eaton Myasthenic Syndrome; Male; Mice; Mice, Inbred ICR; Motor Neurons; Nifedipine; omega-Agatoxin IVA; omega-Conotoxins; Peptides; Plasma; Potassium Channel Blockers; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Spider Venoms; Synaptosomes; Tetraethylammonium; Verapamil | 1998 |
cAMP-dependent phosphorylation sites and macroscopic activity of recombinant cardiac L-type calcium channels.
Topics: Alanine; Amino Acid Substitution; Barium; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dihydropyridines; Humans; Kidney; Membrane Proteins; Muscle Proteins; Mutagenesis, Site-Directed; Myocardium; Patch-Clamp Techniques; Phosphorylation; Recombinant Proteins; Serine; Transfection | 1998 |
Two types of calcium currents of the mouse bipolar cells recorded in the retinal slice preparation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cobalt; Dihydropyridines; Membrane Potentials; Mice; Mice, Inbred Strains; omega-Conotoxin GVIA; Organ Culture Techniques; Patch-Clamp Techniques; Peptides; Retina; Tetraethylammonium | 1998 |
Molecular mechanism of diltiazem interaction with L-type Ca2+ channels.
Topics: Alanine; Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Diltiazem; DNA Mutational Analysis; Electric Conductivity; Electrophysiology; Ion Channel Gating; Isradipine; Muscle, Skeletal; Mutagenesis | 1998 |
Functional interaction between benzothiazepine- and dihydropyridine binding sites of cardiac L-type Ca2+ channels.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cell Line; Dihydropyridines; Diltiazem; Membrane Potentials; Myocardium; Nitrendipine; Patch-Clamp Techniques; Temperature; Thiazepines; Time Factors | 1998 |
Selective cardiodepressant activity of fluodipine, a fluorenone-1,4-dihydropyridine derivative.
Topics: Anesthesia; Animals; Aorta; Atrial Function; Binding, Competitive; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Dicarboxylic Acids; Dihydropyridines; Electrophysiology; Female; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Male; Membrane Potentials; Myocardial Contraction; Myocardium; Nifedipine; Pacemaker, Artificial; Patch-Clamp Techniques; Rabbits; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sinoatrial Node; Vasoconstriction; Vasodilator Agents | 1998 |
Inhibition by local anesthetics of Ca2+ channels in rat anterior pituitary cells.
Topics: Anesthetics, Local; Animals; Bupivacaine; Calcium Channel Blockers; Clone Cells; Dihydropyridines; Dose-Response Relationship, Drug; Lidocaine; Membrane Potentials; Nicardipine; Patch-Clamp Techniques; Pituitary Gland, Anterior; Rats | 1998 |
Complexes of the alpha1C and beta subunits generate the necessary signal for membrane targeting of class C L-type calcium channels.
Topics: Base Sequence; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Cell Membrane; Dihydropyridines; DNA Primers; Humans; Isomerism; Mutagenesis; Palmitic Acid; Signal Transduction | 1999 |
"Atypical" neuromodulatory profile of glutapyrone, a representative of a novel 'class' of amino acid-containing dipeptide-mimicking 1,4-dihydropyridine (DHP) compounds: in vitro and in vivo studies.
Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium Channel Blockers; Dihydropyridines; Dipeptides; Glutamates; Male; Mice; Mice, Inbred ICR; Motor Activity; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Reserpine | 1998 |
Increases in neuronal Ca2+ flux after withdrawal from chronic barbiturate treatment.
Topics: Animals; Barbiturates; Calcium; Calcium Radioisotopes; Cerebral Cortex; Dihydropyridines; Hippocampus; In Vitro Techniques; Male; Mice; Neurons; Radioligand Assay; Substance Withdrawal Syndrome; Synaptosomes; Time Factors | 1999 |
Modulation of neurotransmitter release by dihydropyridine-sensitive calcium channels involves tyrosine phosphorylation.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Adhesion Molecules; Cerebellum; Dihydropyridines; Electrophysiology; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Membrane Potentials; Nerve Tissue Proteins; Nifedipine; omega-Conotoxins; Peptides; Phosphorylation; Potassium; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Time Factors; Tritium; Tyrosine; Vanadates; Vinculin | 1999 |
Effects of morphine in rats withdrawn from repeated nifedipine administration.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Calcium Channel Blockers; Catalepsy; Dihydropyridines; Dopamine; Drug Interactions; In Vitro Techniques; Male; Morphine; Nifedipine; Pain Measurement; Rats; Serotonin; Substance Withdrawal Syndrome; Time Factors | 1999 |
Regional expression and functional characterization of the L-type Ca2+-channel in myocardium from patients with end-stage heart failure and in non-failing human hearts.
Topics: Adolescent; Adult; Aged; Binding Sites; Blotting, Northern; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calsequestrin; Cardiomyopathy, Dilated; Dihydropyridines; Dose-Response Relationship, Drug; Female; Heart; Heart Failure; Humans; Male; Middle Aged; Myocardium; Nifedipine; Tissue Distribution | 1999 |
L-type calcium channels but not N-methyl-D-aspartate receptor channels mediate rhythmic activity induced by cholinergic agonist in motoneurons from turtle spinal cord slices.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cholinergic Fibers; Dihydropyridines; Excitatory Amino Acid Agonists; Magnesium; Motor Neurons; Muscarine; Muscarinic Agonists; N-Methylaspartate; Nicotinic Antagonists; Nifedipine; Organ Culture Techniques; Periodicity; Receptors, N-Methyl-D-Aspartate; Serotonin; Spinal Cord; Tetrodotoxin; Tubocurarine; Turtles | 1999 |
[The effect of membrane channel agonists and antagonists on hemodynamics and vascular tonus].
Topics: Animals; Calcium Channel Agonists; Calcium Channel Blockers; Dihydropyridines; Hemodynamics; Ion Channels; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Vascular Resistance | 1999 |
Arteriolar and venular vasodilating properties of benidipine hydrochloride, a 1,4-dihydropyridine Ca2+ antagonist with long-lasting action, assessed in rat mesenteric microcirculation.
Topics: Adenosine Diphosphate; Analysis of Variance; Animals; Arterioles; Blood Flow Velocity; Blood Vessels; Calcium Channel Blockers; Dihydropyridines; Male; Mesentery; Microcirculation; Platelet Aggregation; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents; Venules | 1999 |
Micellar electrokinetic chromatography as a fast screening method for the determination of 1,4-dihydropyridine calcium antagonists.
Topics: Acetonitriles; Buffers; Calcium Channel Blockers; Chromatography, Micellar Electrokinetic Capillary; Dihydropyridines; Hydrogen-Ion Concentration; Indicators and Reagents; Solutions | 1999 |
Synthesis of antihypertensive agents via coupling reaction of benzothiazepinone and 1,4-dihydropyridine derivatives.
Topics: Antihypertensive Agents; Dihydropyridines; Magnetic Resonance Spectroscopy; Thiazepines | 1994 |
Effects of long-acting versus short-acting calcium channel blockers among older survivors of acute myocardial infarction.
Topics: Aged; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Female; Humans; Male; Myocardial Infarction; Nicardipine; Nifedipine; Proportional Hazards Models; Retrospective Studies; Risk; Survival Analysis; Survivors; Verapamil | 1999 |
Reconstruction of the dihydropyridine site in a non-L-type calcium channel: the role of the IS6 segment.
Topics: Animals; Calcium Channels; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Electrophysiology; Inhibitory Concentration 50; Isradipine; Mutagenesis; Recombinant Fusion Proteins | 1999 |
Effects of L-type voltage-sensitive calcium channel modulators on the discriminative stimulus effects of ethanol in rats.
Topics: Animals; Calcium Channel Blockers; Conditioning, Operant; Dihydropyridines; Discrimination Learning; Ethanol; Feeding Behavior; Isradipine; Male; Nifedipine; Rats; Taste | 1999 |
Stereoselective characterization of the 1,4-dihydropyridine binding site at L-type calcium channels in the resting state and the opened/inactivated state.
Topics: Binding Sites; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Ion Channel Gating; Models, Molecular; Molecular Conformation; Stereoisomerism | 1999 |
Modulation of dihydropyridine-sensitive calcium channels in Drosophila by a cAMP-mediated pathway.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cesium; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dihydropyridines; Drosophila; Enzyme Inhibitors; Isoquinolines; Larva; Membrane Potentials; Muscles; Mutagenesis; Nervous System; Phosphodiesterase Inhibitors; Sulfonamides | 1999 |
Conformational flexibility of voltage gated dihydropyridine sensitive calcium channel in hydrated DMPC bilayer.
Topics: Amino Acid Sequence; Animals; Calcium Channels; Dihydropyridines; Dimyristoylphosphatidylcholine; Ion Channel Gating; Lipid Bilayers; Membrane Potentials; Molecular Conformation; Molecular Sequence Data; Rabbits | 1998 |
Expression of the L-type Ca(2+) channel in AtT-20 cells is regulated by cyclic AMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenocorticotropic Hormone; Animals; Anti-Bacterial Agents; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Corticotropin-Releasing Hormone; Cyclic AMP; Dactinomycin; Dihydropyridines; Gene Expression; Genetic Vectors; Kinetics; Pituitary Gland, Anterior; Radioimmunoassay; Rats; Ribonucleases; RNA, Messenger; Transcription, Genetic | 1999 |
Dexamethasone-mediated inhibition of calcium transients and ACTH release in a pituitary cell line (AtT-20).
Topics: Adrenocorticotropic Hormone; Animals; Calcium; Calcium Channel Blockers; Cell Line; Corticotropin-Releasing Hormone; Dexamethasone; Dihydropyridines; Membrane Potentials; Mice; omega-Agatoxin IVA; Patch-Clamp Techniques; Pituitary Gland; Radioimmunoassay; Spider Venoms; Tumor Cells, Cultured | 1999 |
Effects of prolonged exposure to ethanol in vivo on functional parameters and sensitivity to nitrendipine in the isolated rat heart.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Drug Interactions; Ethanol; Heart; Male; Myocardium; Nitrendipine; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1999 |
1,4-Dihydropyridine calcium channel blockers inhibit plasma and LDL oxidation and formation of oxidation-specific epitopes in the arterial wall and prolong survival in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Apolipoproteins B; Arteries; Calcium Channel Blockers; Cerebrovascular Disorders; Dihydropyridines; Epitopes; Genetic Predisposition to Disease; Immunohistochemistry; Lipoproteins, LDL; Male; Oxidation-Reduction; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reference Values; Vitamin E | 1999 |
Volume regulatory decrease in UMR-106.01 cells is mediated by specific alpha1 subunits of L-type calcium channels.
Topics: Animals; Bone Neoplasms; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Size; Dihydropyridines; Hypotonic Solutions; Nifedipine; Oligonucleotides, Antisense; Osmolar Concentration; Osteoblasts; Osteosarcoma; Patch-Clamp Techniques; Protein Isoforms; Rats; Tumor Cells, Cultured | 1999 |
Cardiac inotropic vs. chronotropic selectivity of isradipine, nifedipine and clevidipine, a new ultrashort-acting dihydropyridine.
Topics: Animals; Calcium Channel Blockers; Cardiotonic Agents; Coronary Circulation; Dihydropyridines; Heart Atria; Heart Block; Heart Rate; Isradipine; Male; Myocardial Contraction; Nifedipine; Pyridines; Rats; Rats, Sprague-Dawley; Systole; Ventricular Function, Left; Ventricular Pressure | 1999 |
Dihydropyridine-sensitive ion currents and charge movement in vesicles derived from frog skeletal muscle plasma membranes.
Topics: Algorithms; Animals; Barium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Membrane; Dihydropyridines; Electrophysiology; In Vitro Techniques; Ion Channels; Magnesium; Membrane Potentials; Muscle, Skeletal; Patch-Clamp Techniques; Ranidae | 1999 |
Synthesis, calcium channel antagonist activity, and anticonvulsant activity of 3-ethyl 5-methyl 1,4-dihydro-2-[(2-hydroxyethoxy) methyl]-6-methyl-4-(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate coupled to a 1-methyl-1,4-dihydropyridyl-3-carbonyl chemical
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Dihydropyridines; Felodipine; Guinea Pigs; Mice; Muscle, Smooth; Nimodipine | 1999 |
Synthesis and X-ray crystal structure of the calcium channel antagonist: dimethyl 1,4-dihydro-2,6-dimethyl-4-[4'-(4H-4-oxo-1-benzopyran-2-yl)phenyl]- 3,5-pyridine dicarboxylate.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Female; Male; Molecular Conformation; Rats; X-Ray Diffraction | 1999 |
Derivatives of 1,4-dihydropyridines as modulators of ascorbate-induced lipid peroxidation and high-amplitude swelling of mitochondria, caused by ascorbate, sodium linoleate and sodium pyrophosphate.
Topics: Animals; Antioxidants; Ascorbic Acid; Calcium Channel Blockers; Dihydropyridines; Diphosphates; Linoleic Acid; Lipid Peroxidation; Male; Mitochondrial Swelling; Molecular Structure; Rats; Rats, Wistar | 1999 |
Role of neuropeptide-sensitive L-type Ca(2+) channels in histamine release in gastric enterochromaffin-like cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenylate Cyclase Toxin; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; DNA Primers; Enterochromaffin-like Cells; Galanin; Gastric Acid; Gastric Mucosa; Gastrins; Gene Expression; GTP-Binding Proteins; Histamine; Histamine Release; Membrane Potentials; Neuropeptides; Neurotransmitter Agents; omega-Conotoxin GVIA; Peptide YY; Pertussis Toxin; Pituitary Adenylate Cyclase-Activating Polypeptide; Potassium; Rabbits; Rats; Receptors, Histamine H2; Somatostatin; Stomach; Tetraethylammonium; Virulence Factors, Bordetella | 1999 |
Vasorelaxation by new hybrid compounds containing dihydropyridine and pinacidil-like moieties.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; CHO Cells; Cricetinae; Dihydropyridines; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mesenteric Arteries; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Spectrophotometry, Infrared; Vasodilator Agents | 1999 |
Calcium channel activation and self-biting in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aggression; Animals; Behavior, Animal; Bites and Stings; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Diltiazem; Ion Channel Gating; Mice; Mice, Inbred C57BL; Nifedipine; Nimodipine; Nitrendipine; Pyrroles; Self-Injurious Behavior | 1999 |
Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials.
Topics: 2-Amino-5-phosphonovalerate; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Barium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calmodulin; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Dihydropyridines; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression; Hippocampus; Ion Channel Gating; N-Methylaspartate; Phosphorylation; Pyramidal Cells; Rats | 2000 |
Photoaffinity labeling and purification of ZG-16p, a high-affinity dihydropyridine binding protein of rat pancreatic zymogen granule membranes that regulates a K(+)-selective conductance.
Topics: Adenosine Triphosphate; Affinity Labels; Animals; Benzophenones; Binding Sites; Dihydropyridines; Enzyme Precursors; In Vitro Techniques; Lectins; Male; Pancreas; Photosensitizing Agents; Potassium Channel Blockers; Rats; Rats, Wistar | 2000 |
Dihydropyridine-sensitive calcium currents in bipolar cells of salamander retina are inhibited by reductions in extracellular chloride.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Ambystoma; Animals; Barium; Calcium Channels, L-Type; Chlorides; Dihydropyridines; Gluconates; In Vitro Techniques; Larva; Membrane Potentials; Nisoldipine; Nystatin; Patch-Clamp Techniques; Photoreceptor Cells, Vertebrate; Retina | 2000 |
Vasorelaxant effect of harman.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Blood Pressure; Brain; Dihydropyridines; Dose-Response Relationship, Drug; Endothelium, Vascular; Harmine; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; Nitric Oxide; Phenylephrine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Serotonin; Serotonin; Vasodilation | 2000 |
Altered L-type Ca(2+) channel currents in vascular smooth muscle cells from experimental diabetic rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Arteries; Bucladesine; Calcium Channels, L-Type; Cells, Cultured; Cyclic AMP; Diabetes Mellitus, Experimental; Dihydropyridines; Electric Conductivity; Glucose; Male; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Tail | 2000 |
Arterial responses in vitro and plasma digoxin immunoreactivity after losartan and enalapril treatments in experimental hypertension.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Cardiomegaly; Digoxin; Dihydropyridines; Enalapril; Heart; Hypertension; Losartan; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Organ Size; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sodium-Potassium-Exchanging ATPase; Tunica Media | 2000 |
High-performance liquid chromatography with amperometric detection applied to the screening of 1,4-dihydropyridines in human plasma.
Topics: Calcium Channel Blockers; Calibration; Chromatography, High Pressure Liquid; Dihydropyridines; Drug Stability; Electrochemistry; Humans; Reproducibility of Results; Sensitivity and Specificity | 2000 |
Oxidative reactivity of S-nitrosoglutathione with Hantzsch 1,4-dihydropyridine.
Topics: Chemistry, Organic; Dihydropyridines; Glutathione; Nitro Compounds; Oxidation-Reduction; Structure-Activity Relationship | 2000 |
Conserved Ca2+-antagonist-binding properties and putative folding structure of a recombinant high-affinity dihydropyridine-binding domain.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Bacterial Proteins; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Cell Membrane; Dihydropyridines; Humans; Models, Molecular; Molecular Sequence Data; Potassium Channels; Protein Binding; Protein Folding; Protein Structure, Tertiary; Rabbits; Recombinant Fusion Proteins; Sequence Alignment; Stereoisomerism; Substrate Specificity; Thermodynamics | 2000 |
Characterization of calcium-mobilizing, purinergic P2Y(2) receptors in human ovarian cancer cells.
Topics: Adenosine Triphosphate; Calcium; Calcium Channel Blockers; Cell Division; Dihydropyridines; Enzyme Activation; Enzyme Inhibitors; Female; Glycerophospholipids; Humans; Nifedipine; Ovarian Neoplasms; Phospholipase D; Potassium; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Thapsigargin; Tumor Cells, Cultured; Uridine Triphosphate | 2000 |
Sodium fluoride increases intracellular calcium in rat renal epithelial cell line NRK-52E.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Transporting ATPases; Cells, Cultured; Chloride Channels; Dihydropyridines; Endoplasmic Reticulum; Enzyme Activation; Epithelium; Kidney; Parathyroid Hormone; Rats; Sodium Fluoride; Type C Phospholipases | 2000 |
Enantiomeric separation of a group of chiral dihydropyridines by electrokinetic chromatography.
Topics: Chromatography, Micellar Electrokinetic Capillary; Cyclodextrins; Dihydropyridines; gamma-Cyclodextrins; Molecular Structure | 2000 |
Managing hypertension in patients with renal disease and diabetes.
Topics: Calcium Channel Blockers; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Dihydropyridines; Humans; Hypertension | 2000 |
Managing hypertension in patients with renal disease and diabetes.
Topics: Calcium Channel Blockers; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Dihydropyridines; Humans; Hypertension | 2000 |
State- and isoform-dependent interaction of isradipine with the alpha1C L-type calcium channel.
Topics: Alternative Splicing; Barium; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Humans; Ion Transport; Isradipine; Membrane Potentials; Muscle, Smooth; Mutagenesis, Site-Directed; Myocardium; Patch-Clamp Techniques; Protein Isoforms; Transfection | 2000 |
Mibefradil, an I(Ca,T) blocker, effectively blocks I(Ca,L) in rabbit sinus node cells.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Female; Mibefradil; Nifedipine; Rabbits; Sinoatrial Node | 2000 |
In vivo specific binding characteristics and pharmacokinetics of a 1,4-dihydropyridine calcium channel antagonist in the senescent mouse brain.
Topics: Aging; Animals; Brain; Calcium Channel Blockers; Dihydropyridines; Isradipine; Male; Mice; Myocardium | 2000 |
Serine residue in the IIIS5-S6 linker of the L-type Ca2+ channel alpha 1C subunit is the critical determinant of the action of dihydropyridine Ca2+ channel agonists.
Topics: Amino Acid Sequence; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cricetinae; Dihydropyridines; Molecular Sequence Data; Point Mutation; Protein Conformation; Protein Subunits; Rats; Serine; Structure-Activity Relationship | 2000 |
Hypotonic swelling increases L-type calcium current in smooth muscle cells of the human stomach.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Barium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Size; Cells, Cultured; Dihydropyridines; Electric Conductivity; Fluorometry; Gastric Mucosa; Humans; Hypotonic Solutions; Muscle, Smooth, Vascular; Osmotic Pressure; Patch-Clamp Techniques; Stomach | 2000 |
Role of dihydropyridine-sensitive calcium channels in meiosis and fertilization in the bivalve molluscs Ruditapes philippinarum and Crassostrea gigas.
Topics: Animals; Bivalvia; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Female; Fertilization; Male; Meiosis; Metaphase; Oocytes; Prophase; Serotonin | 2000 |
The differential time courses of the vasodilator effects of various 1,4-dihydropyridines in isolated human small arteries are correlated to their lipophilicity.
Topics: Adipose Tissue; Adolescent; Adult; Arterioles; Breast; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Linear Models; Middle Aged; Reaction Time; Skin; Vascular Resistance; Vasodilation | 2000 |
Novel cationic amphiphilic 1,4-dihydropyridine derivatives for DNA delivery.
Topics: Animals; Buffers; Cations; Cell Line; Dihydropyridines; DNA; Drug Design; Electrophoresis, Agar Gel; Fatty Acids, Monounsaturated; Galactosidases; Genetic Therapy; Glycerophospholipids; Liposomes; Molecular Structure; Particle Size; Phosphatidylethanolamines; Plasmids; Quaternary Ammonium Compounds; Structure-Activity Relationship; Surface-Active Agents; Transfection | 2000 |
A new synthesis of indoloquinolizines by Pictet-Spengler reaction of tryptamine type 1,2-dihydropyridines utilizing sec-nitrodienamine.
Topics: Butadienes; Dihydropyridines; Indoles; Nitro Compounds; Quinolizines; Tryptamines | 2000 |
Calcium/calmodulin-dependent protein kinase type IV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons.
Topics: Animals; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Cerebellum; Cyclic AMP Response Element-Binding Protein; Dihydropyridines; Genes, Dominant; Mice; Models, Biological; Mutation; Neurons; Neuroprotective Agents; Nifedipine; Phosphorylation; Potassium; Protein Processing, Post-Translational | 2001 |
Calcium channel isoforms underlying synaptic transmission at embryonic Xenopus neuromuscular junctions.
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Electric Stimulation; Excitatory Postsynaptic Potentials; In Vitro Techniques; Neuromuscular Junction; omega-Conotoxins; Patch-Clamp Techniques; Protein Isoforms; Synaptic Transmission; Xenopus | 2001 |
Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcium Channel Agonists; Calcium Channels; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Electric Conductivity; Glutathione Transferase; GTP-Binding Proteins; Humans; Neurons; Protein Isoforms; Recombinant Fusion Proteins | 2001 |
Gadolinium prevents stretch-mediated contractile dysfunction in isolated papillary muscles.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Gadolinium; Guinea Pigs; Heart Failure; Hypoxia; In Vitro Techniques; Ion Channel Gating; Muscle Contraction; Nifedipine; Oxygen; Papillary Muscles | 2001 |
Activation of purified cardiac ryanodine receptors by dihydropyridine agonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Dogs; Membrane Potentials; Myocardium; Nicotinic Acids; Nifedipine; Oxadiazoles; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Stereoisomerism | 2001 |
Chronic nicotine alters NO signaling of Ca(2+) channels in cerebral arterioles.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Arterioles; Barium; Calcium; Calcium Channels; Calcium Channels, L-Type; Cerebral Arteries; Cerebrovascular Circulation; Cyclic GMP; Dihydropyridines; Electric Stimulation; Female; Membrane Potentials; Muscle, Smooth, Vascular; Nicotine; Nifedipine; Nitric Oxide; Nitroprusside; Potassium Channels; Rats; Rats, Inbred WKY; Signal Transduction; Time Factors; Tyrphostins | 2001 |
Abnormality of calcium channel inhibitor released from fetal membranes in preterm labor.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding, Competitive; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Extraembryonic Membranes; Female; Guinea Pigs; Humans; Isradipine; Obstetric Labor, Premature; Organ Specificity; Placenta; Pregnancy; Random Allocation; Rats; Rats, Wistar; Uterine Contraction | 2001 |
Mechanism of dihydropyridine interaction with critical binding residues of L-type Ca2+ channel alpha 1 subunits.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Female; Isoleucine; Isradipine; Kinetics; Methionine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Phenylalanine; Protein Structure, Secondary; Protein Subunits; Recombinant Proteins; Valine; Xenopus laevis | 2001 |
Nifedipine-activated Ca(2+) permeability in newborn rat cortical collecting duct cells in primary culture.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Biological Transport; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cells, Cultured; Cytosol; Dihydropyridines; Diltiazem; Egtazic Acid; Gadolinium; Hydrogen Peroxide; Isradipine; Kidney Cortex; Kidney Tubules, Collecting; Kinetics; Lanthanum; Nifedipine; Protamines; Rats; Rats, Sprague-Dawley; Thapsigargin; Verapamil | 2001 |
Ca(2+) entry into primary cultured pig coronary smooth muscle cells after previous store depletion by repetitive P2Y purinoceptor stimulation.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cations, Divalent; Cells, Cultured; Coronary Vessels; Dihydropyridines; Fura-2; Hydroquinones; Intracellular Fluid; Magnesium; Manganese; Muscle, Smooth, Vascular; Receptors, Purinergic P2; Sarcolemma; Swine | 2001 |
Inhibition of ATP-induced surfactant exocytosis by dihydropyridine (DHP) derivatives: a non-stereospecific, photoactivated effect and independent of L-type Ca2+ channels.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Drug Interactions; Exocytosis; Fura-2; In Vitro Techniques; Light; Male; Molecular Conformation; Photochemistry; Pulmonary Alveoli; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Strontium; Surface-Active Agents | 2001 |
Contribution of the plasmalemma to Ca2+ homeostasis in hair cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium-Transporting ATPases; Cell Membrane; Cell Separation; Cilia; Dihydropyridines; Eosine Yellowish-(YS); Fluorescent Dyes; Guinea Pigs; Hair Cells, Auditory; Homeostasis; Immunohistochemistry; In Vitro Techniques; Membrane Potentials; Organelles; Patch-Clamp Techniques; Potassium | 2001 |
Comparative study on the vasorelaxant effects of three harmala alkaloids in vitro.
Topics: Animals; Aorta, Thoracic; Calcium Channels, L-Type; Cells, Cultured; Dihydropyridines; Endothelium, Vascular; Harmaline; Harmine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Vasodilator Agents | 2001 |
Influence of treatment with Ca(2+) antagonists on cerebral vasculature of spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain; Calcium Channel Blockers; Cerebrovascular Circulation; Dihydropyridines; Hydralazine; Hypertension; Male; Nimodipine; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Wistar | 2001 |
Fundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the major Ca2+ entry pathway.
Topics: Adenosine Triphosphate; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cell Differentiation; Cells, Cultured; Dendritic Cells; Dihydropyridines; Immunophenotyping; Ion Channel Gating; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Thapsigargin | 2001 |
Comparative effects of selective T- and L-type calcium channel blockers in the remnant kidney model.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Homeostasis; Kidney; Male; Mibefradil; Models, Biological; Rats; Rats, Sprague-Dawley | 2001 |
Studies on agents with mixed NO-dependent and calcium channel antagonistic vasodilating activities.
Topics: Animals; Aorta; Calcium Channel Blockers; Cardiovascular Agents; Dihydropyridines; Dose-Response Relationship, Drug; Male; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2001 |
Protein kinase C-mediated calcium entry dependent upon dihydropyridine sensitive channels: a T cell receptor-coupled signaling pathway involved in IL-4 synthesis.
Topics: Calcium; Calcium Channels, L-Type; Dihydropyridines; Humans; In Vitro Techniques; Interleukin-4; Phosphorylation; Protein Kinase C; Receptors, Antigen, T-Cell; Th1 Cells; Th2 Cells; Tyrosine | 2001 |
Functional expression and characterization of a voltage-gated CaV1.3 (alpha1D) calcium channel subunit from an insulin-secreting cell line.
Topics: Androstadienes; Animals; Barium; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Female; Gene Expression; GTP-Binding Proteins; Ion Channel Gating; Isradipine; Myocardium; Neurons; Oocytes; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Receptors, Opioid, mu; Tetradecanoylphorbol Acetate; Wortmannin; Xenopus laevis | 2001 |
Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alternative Splicing; Animals; Barium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Humans; Kidney; Membrane Potentials; Molecular Sequence Data; Nimodipine; Oocytes; Patch-Clamp Techniques; Protein Subunits; Rats; Signal Transduction; Transfection; Xenopus | 2001 |
Searching for balanced hybrid NO-donor 1,4-dihydropyridines with basic properties.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Nicardipine; Nitric Oxide; Nitric Oxide Donors; Rats; Vasodilation | 2001 |
Mechanism of action of angiotensin II in human isolated subcutaneous resistance arteries.
Topics: Amlodipine; Angiotensin II; Arteries; Benzimidazoles; Biphenyl Compounds; Calcium; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Flavonoids; Genistein; Humans; In Vitro Techniques; Nickel; Norepinephrine; Potassium; Ryanodine; Skin; Tetrazoles; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents | 2001 |
Expression of L-type calcium channels associated with postnatal development of skeletal muscle function in mouse.
Topics: Aging; Animals; Animals, Newborn; Boron Compounds; Calcium; Calcium Channels, L-Type; Dihydropyridines; Fluorescent Dyes; Gene Expression Regulation, Developmental; Glycolysis; Intracellular Membranes; Mice; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle Proteins; Muscle, Skeletal; Oxidation-Reduction; Oxygen Consumption; Succinate Dehydrogenase | 2001 |
Torquoselectivity induced by lone-pair conjugation in the electrocyclic reactions of 1-azapolyenes.
Topics: Aza Compounds; Calcium Channel Blockers; Dihydropyridines; Electrons; Models, Molecular; Polyenes; Thermodynamics | 2001 |
3-Methyl 5-isopropyl 2-methoxyiminomethyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.
Topics: Calcium Channel Agonists; Calcium Channel Blockers; Crystallography, X-Ray; Dihydropyridines; Molecular Structure; Nitro Compounds | 2001 |
Dihydropyridine calcium channel blockers and peripheral side effects.
Topics: Calcium Channel Blockers; Dihydropyridines; Edema; Erythema; Exanthema; Humans; Hyperpigmentation; Hypertension; Male; Middle Aged; Nifedipine | 2001 |
Potentiation of the cardiac L-type Ca(2+) channel (alpha(1C)) by dihydropyridine agonist and strong depolarization occur via distinct mechanisms.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Electrophysiology; Heart; Membrane Potentials; Mice; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction | 2001 |
A component of excitation-contraction coupling triggered in the absence of the T671-L690 and L720-Q765 regions of the II-III loop of the dihydropyridine receptor alpha(1s) pore subunit.
Topics: Amino Acid Sequence; Animals; Calcium; Calcium Channels, L-Type; Cells, Cultured; Dihydropyridines; DNA, Complementary; Electrophysiology; Gene Deletion; Heterozygote; Kinetics; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Sequence Data; Muscle, Skeletal; Muscles; Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Transfection | 2001 |
A prokaryotic voltage-gated sodium channel.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Bacillus; Bacterial Proteins; Calcium; Calcium Channel Blockers; Calcium Channels; CHO Cells; COS Cells; Cricetinae; Dihydropyridines; Genes, Bacterial; Ion Channel Gating; Membrane Potentials; Molecular Sequence Data; Molecular Weight; Open Reading Frames; Patch-Clamp Techniques; Protein Structure, Tertiary; Recombinant Proteins; Sodium; Sodium Channels; Tetrodotoxin; Transfection | 2001 |
The learned symmetry concept in revealing quantitative structure-activity relationships with artificial neural networks.
Topics: Calcium Channel Blockers; Dihydropyridines; Hallucinogens; Models, Chemical; Neural Networks, Computer; Structure-Activity Relationship | 2001 |
Effect of acyl chain length and branching on the enantioselectivity of Candida rugosa lipase in the kinetic resolution of 4-(2-difluoromethoxyphenyl)-substituted 1,4-dihydropyridine 3,5-diesters.
Topics: Binding Sites; Candida; Carboxylic Acids; Catalysis; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Dihydropyridines; Esters; Hydrolases; Hydrolysis; Kinetics; Lipase; Magnetic Resonance Spectroscopy; Molecular Structure; Stereoisomerism; Substrate Specificity | 2002 |
Role of dihydropyridine-sensitive calcium channels in the regulation of norepinephrine release in hypertension.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Dose-Response Relationship, Drug; Hypertension; Male; Mesenteric Arteries; Nicardipine; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2001 |
Calcium involvement in the luminescence control of three ophiuroid species (Echinodermata).
Topics: Animals; Barium; Benzodiazepines; Cadmium; Calcium; Calcium Channel Blockers; Carrier Proteins; Cobalt; Dihydropyridines; Echinodermata; Ion Channel Gating; Luminescence; Neurons; Nickel; Seawater; Species Specificity; Strontium; Trifluoperazine | 2002 |
Enhanced vascular effects of the Ca(2+) channel agonist Bay K 8644 in pregnant rabbits.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 6-Ketoprostaglandin F1 alpha; Anesthesia; Animals; Aorta; Blood Pressure; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cardiac Output; Consciousness; Dihydropyridines; Female; Heart Rate; Muscle, Smooth, Vascular; Nifedipine; Pregnancy; Pregnancy, Animal; Rabbits; Thromboxane B2; Tritium | 2002 |
The effect of ionizing radiation on some derivatives of 1,4-dihydropyridine in the solid state.
Topics: Beta Particles; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Radiation; Gamma Rays | 2002 |
Independent modulation of L-type Ca2+ channel in guinea pig ventricular cells by nitrendipine and isoproterenol.
Topics: Adrenergic beta-Agonists; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Colforsin; Dihydropyridines; Electrophysiology; Evoked Potentials; Guinea Pigs; Heart Ventricles; Isoproterenol; Nitrendipine; Patch-Clamp Techniques; Phosphorylation | 2001 |
A novel water-soluble Hantzsch 1,4-dihydropyridine compound that functions in biological processes through NADH regeneration.
Topics: Chemistry, Organic; Dihydropyridines; Escherichia coli; Membranes; Molecular Structure; NAD; Structure-Activity Relationship | 2002 |
A spectroscopic investigation of hydrogen bond patterns in crystalline and amorphous phases in dihydropyridine calcium channel blockers.
Topics: Calcium Channel Blockers; Crystallization; Dihydropyridines; Hydrogen Bonding; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman | 2002 |
The effect of temperature on hydrogen bonding in crystalline and amorphous phases in dihydropyrine calcium channel blockers.
Topics: Calcium Channel Blockers; Cold Temperature; Crystallization; Dihydropyridines; Hot Temperature; Hydrogen Bonding; Temperature | 2002 |
Extracellular and intracellular factors influencing gene transfection mediated by 1,4-dihydropyridine amphiphiles.
Topics: Animals; Cell Line; Dihydropyridines; DNA; Extracellular Space; Haplorhini; Intracellular Fluid; Liposomes; Surface-Active Agents; Transfection | 2002 |
Streptomyces serine protease (DHP-A) as a new biocatalyst capable of forming chiral intermediates of 1,4-dihydropyridine calcium antagonists.
Topics: Amino Acid Sequence; Catalysis; Cloning, Molecular; Dihydropyridines; Gene Expression; Hydrolysis; Molecular Conformation; Molecular Sequence Data; Sequence Homology, Amino Acid; Serine Endopeptidases; Streptomyces; Substrate Specificity | 2002 |
Face-selective addition to a cation-pi complex of a pyridinium salt: synthesis of chiral 1,4-dihydropyridines.
Topics: Cations; Crystallography, X-Ray; Dihydropyridines; Magnetic Resonance Spectroscopy; Pyridinium Compounds; Stereoisomerism | 2002 |
Passive transfer of Lambert-Eaton syndrome to mice induces dihydropyridine sensitivity of neuromuscular transmission.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Diaphragm; Dihydropyridines; Humans; Immunization, Passive; Lambert-Eaton Myasthenic Syndrome; Male; Mice; Mice, Inbred ICR; Motor Neurons; Neuromuscular Junction; Synaptic Transmission | 2002 |
Comparison of losartan with ACE inhibitors and dihydropyridine calcium channel antagonists: a pilot study of prescription-event monitoring in Japan.
Topics: Aged; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Chi-Square Distribution; Cohort Studies; Cough; Dihydropyridines; Drug Monitoring; Exanthema; Female; Humans; Japan; Losartan; Male; Middle Aged; Pilot Projects; Surveys and Questionnaires | 2002 |
The L-type voltage-dependent Ca2+ channel EGL-19 controls body wall muscle function in Caenorhabditis elegans.
Topics: Action Potentials; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Locomotion; Muscle Proteins; Muscles; Mutation; Patch-Clamp Techniques; Sodium Chloride | 2002 |
Gas chromatography/mass spectrometric study of non-commercial C-4-substituted 1,4-dihydropyridines and their oxidized derivatives.
Topics: Calcium Channel Blockers; Dihydropyridines; Electrolysis; Gas Chromatography-Mass Spectrometry; Molecular Structure; Oxidation-Reduction | 2002 |
Inhibition of cAMP signalling cascade-mediated Ca2+ influx by a prothoracicostatic peptide (Mas-MIP I) via dihydropyridine-sensitive Ca2+ channels in the prothoracic glands of the silkworm, Bombyx mori.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bombyx; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cells, Cultured; Colforsin; Cyclic AMP; Dihydropyridines; Exocrine Glands; Kinetics; Larva; Signal Transduction | 2003 |
Pharmacological characterization of a 1,4-dihydropyridine analogue, 9-(3,4-dichlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione (A-184209) as a novelK(ATP) channel inhibitor.
Topics: Acridines; Animals; Aorta, Thoracic; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley | 2003 |
Location of ryanodine and dihydropyridine receptors in frog myocardium.
Topics: Animals; Calcium Channels, L-Type; Cryoultramicrotomy; Dihydropyridines; Heart Atria; Heart Ventricles; In Vitro Techniques; Microscopy, Electron, Scanning; Myocardium; Rana temporaria; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Statistics as Topic; Tissue Distribution | 2003 |
Functional interaction of auxiliary subunits and synaptic proteins with Ca(v)1.3 may impart hair cell Ca2+ current properties.
Topics: Animals; Botulinum Toxins; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Hair Cells, Auditory; Humans; Ion Channel Gating; Kidney; Membrane Potentials; Membrane Proteins; Nerve Tissue Proteins; Qa-SNARE Proteins; R-SNARE Proteins; Rana catesbeiana; Recombinant Proteins; Synapses; Synaptosomal-Associated Protein 25; Transfection | 2003 |
Reactivity of 1,4-dihydropyridines toward alkyl, alkylperoxyl radicals, and ABTS radical cation.
Topics: Benzothiazoles; Cations; Chromans; Dihydropyridines; Free Radical Scavengers; Free Radicals; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Kinetics; Nisoldipine; Peroxides; Spectrophotometry, Ultraviolet; Sulfonic Acids; Vitamin E | 2003 |
Modulation of cardiac Ca(V)1.2 channels by dihydropyridine and phosphatase inhibitor requires Ser-1142 in the domain III pore loop.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Calcium Channel Agonists; Calcium Channels; Calcium Channels, L-Type; Cell Line; Cell Membrane; Cricetinae; Dihydropyridines; Electrophysiology; Enzyme Inhibitors; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Okadaic Acid; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rabbits; Serine; Threonine; Time Factors; Transfection | 2003 |
Ca v 1.3 is preferentially coupled to glucose-stimulated insulin secretion in the pancreatic beta-cell line INS-1.
Topics: Calcium Channels, L-Type; Cell Line; Dihydropyridines; Glucose; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Protein Structure, Tertiary | 2003 |
Effects of UV and visible light on cyanobacteria at the cellular level.
Topics: Cyanobacteria; Dihydropyridines; Sunlight | 2002 |
New carrier for specific delivery of drugs to the brain.
Topics: Animals; Blood-Brain Barrier; Brain; Dihydropyridines; Drug Carriers; Drug Design; Drug Stability; Half-Life; Humans; Hydrogen-Ion Concentration; Hydrolysis; Oxidation-Reduction; Phenethylamines; Rabbits; Tissue Distribution; Tryptamines | 2003 |
Nature and expression of dihydropyridine-sensitive and -insensitive calcium currents in hair cells of frog semicircular canals.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Gene Expression Regulation; Hair Cells, Auditory; Membrane Potentials; Rana esculenta; Semicircular Canals | 2003 |
Modulation of L-type Ca2+ channels in neonatal rat heart by a novel Ca2+ channel agonist.
Topics: Animals; Animals, Newborn; Azocines; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Myocytes, Cardiac; Patch-Clamp Techniques; Rats | 2003 |
The L-type Ca2+-channel subunits alpha1C and beta2 are not downregulated in atrial myocardium of patients with chronic atrial fibrillation.
Topics: Animals; Atrial Fibrillation; Binding Sites; Calcium Channels, L-Type; Chronic Disease; Dihydropyridines; Down-Regulation; Humans; Protein Binding; Rabbits | 2003 |
Potentiated L-type Ca2+ channels rectify.
Topics: Animals; Calcium Channels, L-Type; Dihydropyridines; DNA, Complementary; Electrophysiology; Gene Expression Regulation; Ion Channel Gating; Magnesium; Mice; Muscle Fibers, Skeletal | 2003 |
Enantiomeric separation by HPLC of 1,4-dihydropyridines with vancomycin as chiral selector.
Topics: Amlodipine; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Dihydropyridines; Models, Molecular; Molecular Conformation; Stereoisomerism; Vancomycin | 2003 |
[125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Dihydropyridines; Guinea Pigs; Heart; Iodine Radioisotopes; Kinetics; Male; Membrane Proteins; Myocardium; Potassium Channels; Pyridines; Radioligand Assay; Radiopharmaceuticals; Thiophenes; Urinary Bladder | 2003 |
Modulation of manganese currents by 1, 4-dihydropyridines, isoproterenol and forskolin in rabbit ventricular cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic beta-Agonists; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Colforsin; Cyclic AMP; Dihydropyridines; Electrophysiology; Heart Ventricles; In Vitro Techniques; Ion Channel Gating; Ion Channels; Isoproterenol; Manganese; Membrane Potentials; Myocardium; Myocytes, Cardiac; Nitrendipine; Patch-Clamp Techniques; Rabbits; Signal Transduction | 2003 |
Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amino Acid Sequence; Barium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Cloning, Molecular; Dihydropyridines; Humans; Ion Channel Gating; Isradipine; Kidney; Molecular Sequence Data; Patch-Clamp Techniques; Protein Subunits; Sequence Homology, Amino Acid; Transfection | 2003 |
Key roles of Phe1112 and Ser1115 in the pore-forming IIIS5-S6 linker of L-type Ca2+ channel alpha1C subunit (CaV 1.2) in binding of dihydropyridines and action of Ca2+ channel agonists.
Topics: Alanine; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Isradipine; Phenylalanine; Point Mutation; Protein Subunits; Pyrroles; Rats; Repetitive Sequences, Nucleic Acid; Serine | 2003 |
DHP-insensitive L-type-like Ca channel of ascidian acquires sensitivity to DHP with single amino acid change in domain III P-region.
Topics: Amino Acid Substitution; Animals; Barium; Base Sequence; Calcium Channels, L-Type; Dihydropyridines; Electrophysiology; Humans; Larva; Mammals; Molecular Sequence Data; Protein Structure, Tertiary; Protein Subunits; Urochordata | 2003 |
Modified cardiovascular L-type channels in mice lacking the voltage-dependent Ca2+ channel beta3 subunit.
Topics: Animals; Aorta; Blood Pressure; Blotting, Western; Calcium; Calcium Channels; Calcium Channels, L-Type; Cardiovascular System; CHO Cells; Cricetinae; Dihydropyridines; Dose-Response Relationship, Drug; Electrophysiology; Green Fluorescent Proteins; Immunohistochemistry; Kinetics; Luminescent Proteins; Mice; Mice, Transgenic; Myocardium; Protein Binding; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
L-type calcium channel activation up-regulates the mRNAs for two different sodium channel alpha subunits (Nav1.2 and Nav1.3) in rat pituitary GH3 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Drug Interactions; Gene Expression Regulation; NAV1.2 Voltage-Gated Sodium Channel; NAV1.3 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Nimodipine; Nucleic Acid Amplification Techniques; Pituitary Gland; Protein Subunits; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Sodium Channels; Up-Regulation | 2003 |
Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dihydropyridines; Disease Models, Animal; Enzyme Inhibitors; Glycogen Phosphorylase; Hypoglycemic Agents; Mice | 2003 |
Synthesis and anticonvulsant activity of novel 1-substituted-1,2-dihydro-pyridazine-3,6-diones.
Topics: Animals; Anticonvulsants; Dihydropyridines; Female; Male; Mice; Pyridazines; Seizures; Structure-Activity Relationship | 2003 |
Clinical and economic consequences of reference pricing for dihydropyridine calcium channel blockers.
Topics: Aged; Aged, 80 and over; British Columbia; Calcium Channel Blockers; Cost Sharing; Costs and Cost Analysis; Dihydropyridines; Drug Costs; Female; Health Services for the Aged; Humans; Income; Male; Pharmacoepidemiology | 2003 |
Synthesis, in vitro and in vivo evaluation of a delivery system for targeting anticancer drugs to the brain.
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain; Dihydropyridines; Drug Carriers; Male; Molecular Structure; Oxidation-Reduction; Rats; Rats, Wistar | 2003 |
Hypothyroidism does not affect the dihydropyridine sensitivity of precontracted murine uterus.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Differentiation; Dihydropyridines; Female; Hypothyroidism; In Vitro Techniques; Isradipine; Mice; Mice, Inbred C57BL; Muscle, Smooth; Thyroid Hormones; Uterine Contraction; Uterus | 2003 |
Characteristics of treated hypertension in incident hemodialysis and peritoneal dialysis patients.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Cardiovascular Diseases; Cause of Death; Cohort Studies; Comorbidity; Diabetes Mellitus; Dihydropyridines; Drug Prescriptions; Drug Utilization; Female; Humans; Hypertension; Kidney Failure, Chronic; Logistic Models; Lung Diseases; Male; Middle Aged; Peritoneal Dialysis; Prospective Studies; Renal Dialysis | 2003 |
Polyphenolic antioxidants mimic the effects of 1,4-dihydropyridines on neurotensin receptor function in PC3 cells.
Topics: Antioxidants; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electron-Transferring Flavoproteins; Flavonoids; Humans; Male; Oxidation-Reduction; Oxidoreductases; Phenols; Polyphenols; Potassium; Receptors, Neurotensin; Sodium; Sulfhydryl Compounds; Tumor Cells, Cultured | 2004 |
Dihydropyridine neuropeptide Y Y1 receptor antagonists 2. bioisosteric urea replacements.
Topics: Caco-2 Cells; Cell Membrane Permeability; Cells, Cultured; Dihydropyridines; Drug Evaluation, Preclinical; Guanidines; Humans; Phenylurea Compounds; Receptors, Neuropeptide Y; Stereoisomerism; Structure-Activity Relationship; Urea | 2004 |
Inhibition of type A GABA receptors by L-type calcium channel blockers.
Topics: 4-Butyrolactone; Animals; Benzodiazepines; Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Humans; Hypothalamus; Kidney; Mutagenesis, Site-Directed; Nitrendipine; Picrotoxin; Protein Structure, Tertiary; Rats; Receptors, GABA-A; Recombinant Proteins; Solvents; Species Specificity; Zinc | 2004 |
Disruption of intestinal motility by a calcium channel-stimulating autoantibody in type 1 diabetes.
Topics: Adult; Aged; Animals; Autoantibodies; Binding Sites; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Colon; Diabetes Mellitus, Type 1; Dihydropyridines; Female; Gastrointestinal Motility; Humans; Intestinal Diseases; Male; Mice; Middle Aged; Myoelectric Complex, Migrating; Vas Deferens | 2004 |
Cloning of the Cav 1.3 (alpha1D) L-type Ca2+ channel from mouse and its expression in the liver.
Topics: Alternative Splicing; Animals; Brain; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cloning, Molecular; Dihydropyridines; DNA, Complementary; Female; Humans; Liver; Mice; Mice, Inbred BALB C; Models, Genetic; Open Reading Frames; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA | 2004 |
Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates.
Topics: Alkaloids; Amines; Dihydropyridines; Isoquinolines; Magnetic Resonance Spectroscopy; Molecular Structure; Reference Standards | 2004 |
HPLC enantiomer separation of a chiral 1,4-dihydropyridine monocarboxylic acid.
Topics: Carboxylic Acids; Chromatography, High Pressure Liquid; Dihydropyridines; Stereoisomerism | 2004 |
Decoration of dihydropyrimidine and dihydropyridine scaffolds with sugars via Biginelli and Hantzsch multicomponent reactions: an efficient entry to a collection of artificial nucleosides.
Topics: Carbohydrates; Dihydropyridines; Glycosylation; Nifedipine; Nucleosides; Pyrimidines; Stereoisomerism; Thiones | 2003 |
Structural effects on the reactivity 1,4-dihydropyridines with alkylperoxyl radicals and ABTS radical cation.
Topics: Benzothiazoles; Cations; Dihydropyridines; Free Radicals; Mass Spectrometry; Peroxides; Spectrophotometry, Ultraviolet; Sulfonic Acids | 2004 |
Dihydropiridines mechanism of action in striatal isolated nerve endings: comparison with omega-agatoxin IVA.
Topics: Animals; Calcium Channel Blockers; Corpus Striatum; Dihydropyridines; In Vitro Techniques; Kinetics; Male; Nerve Endings; omega-Agatoxin IVA; Rats; Rats, Wistar | 2004 |
The SYST-EUR study and beyond: immediate versus delayed treatment of isolated systolic hypertension.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Europe; Follow-Up Studies; Humans; Hypertension; Randomized Controlled Trials as Topic; Stroke; Survival Rate | 2004 |
MRS study of the interaction of dihydropyridines with lipid molecules in phosphatidylcholine vesicles.
Topics: Dihydropyridines; Dimyristoylphosphatidylcholine; Lipid Metabolism; Lipids; Liposomes; Magnetic Resonance Spectroscopy; Molecular Structure; Nifedipine | 2003 |
Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook.
Topics: Animals; Asteraceae; Biomarkers; Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Dihydropyridines; DNA; DNA Adducts; Male; Mass Spectrometry; Microsomes, Liver; Plant Extracts; Pyrrolizidine Alkaloids; Rats | 2004 |
Molecular mechanisms of vasoselectivity of the 1,4-dihydropyridine lercanidipine.
Topics: Animals; Calcium Channels, L-Type; CHO Cells; Cricetinae; Dihydropyridines; Dose-Response Relationship, Drug; Endothelium, Vascular; Protein Isoforms; Rabbits | 2004 |
Marrubenol interacts with the phenylalkylamine binding site of the L-type calcium channel.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Diterpenes; Furans; Ileum; In Vitro Techniques; Isradipine; Male; Membranes; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Radioligand Assay; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 2004 |
Synthesis and biological evaluation of 1,4-dihydropyridine calcium channel modulators having a diazen-1-ium-1,2-diolate nitric oxide donor moiety for the potential treatment of congestive heart failure.
Topics: Animals; Azo Compounds; Dihydropyridines; Drug Evaluation, Preclinical; Guinea Pigs; Heart Failure; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Muscle, Smooth; Nitric Oxide Donors; Spectrophotometry, Infrared | 2004 |
Application of ab initio theory to QSAR study of 1,4-dihydropyridine-based calcium channel blockers using GA-MLR and PC-GA-ANN procedures.
Topics: Algorithms; Calcium Channel Blockers; Computational Biology; Dihydropyridines; Linear Models; Neural Networks, Computer; Predictive Value of Tests; Quantitative Structure-Activity Relationship | 2004 |
Screening for dihydropyridine calcium channel blockers in plasma by automated solid-phase extraction and liquid chromatography/tandem mass spectrometry.
Topics: Automation; Calcium Channel Blockers; Calcium Channels; Chromatography, Liquid; Dihydropyridines; Mass Spectrometry; Molecular Structure; Reproducibility of Results | 2004 |
Proliferation of cultured human gingival fibroblasts caused by isradipine, a dihydropyridine-derivative calcium antagonist.
Topics: Calcium; Calcium Channel Blockers; Cell Division; Cell Line; Collagen Type I; Culture Media; Dihydropyridines; Fibroblast Growth Factors; Fibroblasts; Gingiva; Humans; Isradipine | 2004 |
Dioleoyl phosphatidylethanolamine and PEG-lipid conjugates modify DNA delivery mediated by 1,4-dihydropyridine amphiphiles.
Topics: Cell Line; Dihydropyridines; DNA; Genetic Vectors; Humans; Liposomes; Molecular Structure; Phosphatidylethanolamines; Polyethylene Glycols; Surface-Active Agents; Transfection | 2004 |
Effects of benidipine, a dihydropyridine-Ca2+ channel blocker, on expression of cytokine-induced adhesion molecules and chemoattractants in human aortic endothelial cells.
Topics: Antioxidants; Aorta; Calcium Channel Blockers; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Chemokine CCL2; Chemotactic Factors; Cytokines; Dihydropyridines; Dose-Response Relationship, Drug; Endothelial Cells; Gene Expression; Humans; Intercellular Adhesion Molecule-1; Interleukin-1; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stereoisomerism; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2004 |
1,4-dihydropyridines: reactivity of nitrosoaryl and nitroaryl derivatives with alkylperoxyl radicals and ABTS radical cation.
Topics: Benzothiazoles; Cations; Chromatography, High Pressure Liquid; Dihydropyridines; Free Radicals; Gas Chromatography-Mass Spectrometry; Molecular Structure; Nitro Compounds; Peroxides; Sulfonic Acids | 2004 |
Opposite effects of a single IIIS5 mutation on phenylalkylamine and dihydropyridine interaction with L-type Ca2+ channels.
Topics: Animals; Brain; Calcium; Calcium Channels; Calcium Channels, L-Type; Carrier Proteins; Cell Membrane; Dihydropyridines; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Gallopamil; Homozygote; In Situ Hybridization; Isradipine; Kinetics; Mice; Mice, Transgenic; Microsomes; Models, Biological; Mutation; Oocytes; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; RNA, Complementary; Steroid Isomerases; Tyrosine; Verapamil; Xenopus laevis | 2004 |
Isosteric N-arylpiperazine replacements in a series of dihydropyridine NPY1 receptor antagonists.
Topics: Biomimetic Materials; Chlorides; Dihydropyridines; Drug Evaluation, Preclinical; Molecular Structure; Piperazines; Piperidines; Receptors, Neuropeptide Y; Structure-Activity Relationship; Zinc Compounds | 2004 |
Applying pattern recognition methods and structure property correlations to determine drug carrier potential of nicotinic acid and analogize to dihydropyridine.
Topics: Dihydropyridines; Drug Carriers; Nicotinic Acids; Pattern Recognition, Automated; Structure-Activity Relationship | 2005 |
Quantitative structure-activity relationship studies on some series of calcium channel blockers.
Topics: Animals; Aorta; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Hydrogen Bonding; Inhibitory Concentration 50; Models, Chemical; Potassium; Quantitative Structure-Activity Relationship; Rabbits | 2004 |
Case studies in hypertension. Dihydropyridine/nondihydropyridine calcium channel blocker combination therapy.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Drug Therapy, Combination; Female; Humans; Hypertension; Lisinopril; Male; Middle Aged; Nifedipine; Verapamil | 2005 |
Emergence of a R-type Ca2+ channel (CaV 2.3) contributes to cerebral artery constriction after subarachnoid hemorrhage.
Topics: Animals; Blood; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, R-Type; Cerebral Arteries; Cisterna Magna; Dihydropyridines; Diltiazem; Disease Models, Animal; Drug Resistance; Injections; Ion Transport; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Rabbits; Spider Venoms; Subarachnoid Hemorrhage; Vasoconstriction; Vasospasm, Intracranial | 2005 |
Intraglomerular inhibition: signaling mechanisms of an olfactory microcircuit.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Bicuculline; Cadmium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Signaling; Chelating Agents; Dendrites; Diagnostic Imaging; Dihydropyridines; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Neural Conduction; Neural Inhibition; Neural Networks, Computer; Neurons; Nickel; Nimodipine; Olfactory Bulb; Patch-Clamp Techniques; Phosphinic Acids; Potassium; Propanolamines; Pyrimidines; Rats; Rats, Sprague-Dawley; Signal Transduction; Synapses; Synaptic Transmission; Tetrodotoxin; Time Factors; Valine | 2005 |
Hantzsch 1,4-dihydropyridines containing a diazen-1-ium-1,2-diolate nitric oxide donor moiety to study calcium channel antagonist structure-activity relationships and nitric oxide release.
Topics: Animals; Azo Compounds; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Magnetic Resonance Spectroscopy; Mass Spectrometry; Nitric Oxide; Nitric Oxide Donors; Structure-Activity Relationship | 2005 |
Substituted thiazolamide coupled to a redox delivery system: a new gamma-secretase inhibitor with enhanced pharmacokinetic profile.
Topics: Alzheimer Disease; Amides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Biological Availability; Blood-Brain Barrier; Dihydropyridines; Drug Delivery Systems; Endopeptidases; Enzyme Inhibitors; Humans; Male; Molecular Structure; Nicotinic Acids; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Thiazoles | 2005 |
Evaluation of a simple carrier molecule to enhance drug penetration of dermal layers by utilizing multivariate methods, structure property correlations, and continuous system modeling.
Topics: Administration, Topical; Anti-Bacterial Agents; Cluster Analysis; Dihydropyridines; Drug Carriers; Models, Biological; Models, Chemical; Molecular Structure; Niacin; Permeability; Skin; Structure-Activity Relationship | 2004 |
An approach for measuring in vivo cerebral redox states using the oxidative conversion of dihydropyridine to pyridinium ion and the metabolic trapping principle.
Topics: Animals; Brain; Dihydropyridines; Free Radicals; Glutathione; Magnetic Resonance Spectroscopy; Mice; Oxidation-Reduction; Pyridinium Compounds; Spectrophotometry, Ultraviolet | 2005 |
1,4-Dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Female; Flavones; Guinea Pigs; Heart Atria; Nifedipine; Vasodilator Agents | 2005 |
Effect of compression on interaction between 1,4-dihydropyridine compounds and lactose monohydrate.
Topics: Compressive Strength; Dihydropyridines; Drug Interactions; Lactose; Temperature | 2005 |
Biomimetic oxidation of Hantzsch 1,4-dihydropyridines with tetra-n-butylammonium periodate catalyzed by tetraphenylporphyrinatomanganese(III) chloride [Mn(TPP)Cl].
Topics: Biomimetics; Catalysis; Dihydropyridines; Metalloporphyrins; Oxidation-Reduction; Periodic Acid | 2005 |
Cerebrocrast promotes the cotransport of H+ and Cl- in rat liver mitochondria.
Topics: Adenosine Diphosphate; Analysis of Variance; Animals; Biological Transport; Chlorides; Dihydropyridines; Dimyristoylphosphatidylcholine; Intracellular Membranes; Lipid Bilayers; Lipids; Male; Membrane Potentials; Mitochondria; Mitochondria, Liver; Models, Chemical; Protons; Rats; Rats, Wistar; Spectrometry, Fluorescence; Temperature; Thermodynamics | 2005 |
PHARMAC responds to Stewart Mann on dihydropyridine calcium channel antagonists.
Topics: Calcium Channel Blockers; Dihydropyridines; Drug Costs; Drug Industry; Drugs, Generic; Humans; New Zealand; Therapeutic Equivalency | 2005 |
HPLC method for analysis of a new 1,4-dihydropyridine: application to pharmacokinetic study in rabbit.
Topics: Acetonitriles; Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Dihydropyridines; Drug Stability; Male; Photochemistry; Rabbits; Reproducibility of Results; Temperature; Water | 2006 |
Antihypertensive 1,4-dihydropyridines as correctors of the cystic fibrosis transmembrane conductance regulator channel gating defect caused by cystic fibrosis mutations.
Topics: Animals; Antihypertensive Agents; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dihydropyridines; Electrophysiology; Ion Channel Gating; Mice; Mutation; Rats; Rats, Inbred F344; Thyroid Gland; Transfection | 2005 |
A 1,4-dihydropyridine derivative reduces DNA damage and stimulates DNA repair in human cells in vitro.
Topics: Cell Culture Techniques; Dihydropyridines; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Kinetics; Lymphocytes; Niacin | 2005 |
Parallel, solution phase synthesis of dihydropyridine miticides via a versatile multicomponent reaction.
Topics: Agrochemicals; Animals; Chemistry, Agricultural; Combinatorial Chemistry Techniques; Dihydropyridines; Insecticides; Mites; Solutions; Structure-Activity Relationship; Tick Control | 2005 |
Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Dihydropyridines; Formaldehyde; Molecular Structure; Pain; Pain Measurement; Rats; Structure-Activity Relationship | 2006 |
Rapid and efficient oxidation of Hantzsch 1,4-dihydropyridines with sodium periodate catalyzed by manganese (III) Schiff base complexes.
Topics: Catalysis; Dihydropyridines; Manganese; Oxidation-Reduction; Periodic Acid; Schiff Bases | 2006 |
Substantial reaction between histamine and malondialdehyde: a new observation of carbonyl stress.
Topics: Chromatography, High Pressure Liquid; Dihydropyridines; Histamine; Malondialdehyde; Neurotoxins; Nitrogen Compounds; Protein Carbonylation | 2005 |
Instability of calcium channel antagonists during sample preparation for LC-MS-MS analysis of serum samples.
Topics: Calcium Channel Blockers; Dihydropyridines; Drug Stability; Gas Chromatography-Mass Spectrometry; Humans; Molecular Structure; Photolysis; Specimen Handling; Spectrometry, Mass, Electrospray Ionization | 2006 |
The L-type calcium channel blockers, hantzsch 1,4-dihydropyridines, are not peroxyl radical-trapping, chain-breaking antioxidants.
Topics: Acridines; Antioxidants; Benzene Derivatives; Biphenyl Compounds; Calcium Channel Blockers; Calcium Channels, L-Type; Chromans; Dihydropyridines; Free Radicals; Hydrazines; Kinetics; Nifedipine; Nimodipine; Oxidation-Reduction; Peroxides; Picrates; Styrene | 2006 |
Mild and efficient oxidation of Hantzsch 1,4-dihydropyridines with sodium periodate catalyzed by a new polystyrene-bound Mn(TPP)Cl.
Topics: Catalysis; Crystallography, X-Ray; Dihydropyridines; Organometallic Compounds; Oxidation-Reduction; Periodic Acid; Polystyrenes; Porphyrins | 2006 |
Nitro radical anion formation from nitrofuryl substituted 1,4-dihydropyridine derivatives in mixed and non-aqueous media.
Topics: Anions; Dihydropyridines; Electrochemistry; Free Radicals; Hydrogen-Ion Concentration; Molecular Structure; Niacin; Nitro Compounds; Nitrofurans; Quaternary Ammonium Compounds | 2006 |
Solid phase synthesis of a redox delivery system with the aim of targeting peptides into the brain.
Topics: Amino Acid Sequence; Biochemistry; Borohydrides; Brain; Dihydropyridines; Drug Delivery Systems; Humans; Molecular Sequence Data; NAD; Neuropeptides; Oxidation-Reduction; Quinolines; Quinolinium Compounds; Spectrophotometry, Ultraviolet | 2006 |
The cGMP/protein kinase G pathway contributes to dihydropyridine-sensitive calcium response and cytokine production in TH2 lymphocytes.
Topics: Animals; Calcium; CD4-Positive T-Lymphocytes; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytokines; Dihydropyridines; Guanylate Cyclase; Interleukin-4; Mice; Mice, Inbred BALB C; Mice, Transgenic; NFATC Transcription Factors; Nitric Acid; Th2 Cells | 2006 |
QSAR study of 1,4-dihydropyridine calcium channel antagonists based on gene expression programming.
Topics: Algorithms; Artificial Intelligence; Calcium Channel Blockers; Dihydropyridines; Drug Evaluation, Preclinical; Gene Expression; Quantitative Structure-Activity Relationship | 2006 |
Cocrystals of diastereoisomers of 1,4-dihydropyridine derivatives.
Topics: Crystallization; Crystallography, X-Ray; Dihydropyridines; Models, Molecular; Molecular Structure; Stereoisomerism | 2006 |
Biological evaluation of bishydroxymethyl-substituted cage dimeric 1,4-dihydropyridines as a novel class of p-glycoprotein modulating agents in cancer cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Proliferation; Dihydropyridines; Dimerization; Hydroxylation; Methylation; Mice; Molecular Structure; Neoplasms; Structure-Activity Relationship | 2006 |
Design, synthesis, and calcium channel antagonist activity of new 1,4-dihydropyridines containing 4-(5)-chloro-2-ethyl-5-(4)-imidazolyl substituent.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Drug Design; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Male; Molecular Structure; Muscle Relaxation; Muscle, Smooth; Nifedipine; Structure-Activity Relationship | 2006 |
Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process.
Topics: Adrenergic alpha-Antagonists; Benzofurans; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Glyburide; GTP-Binding Proteins; Humans; Hypoglycemic Agents; Imidazoles; Imidazolines; Insulin-Secreting Cells; RNA, Messenger; Transcription, Genetic | 2006 |
The effect of ionizing radiation of 1,4-dihydropyridine derivatives in the solid state.
Topics: Calcium Channel Blockers; Dihydropyridines; Electron Spin Resonance Spectroscopy; Felodipine; Gamma Rays; Humans; Hypertension; Models, Molecular; Molecular Conformation; Myocardial Ischemia; Nifedipine; Nimodipine | 2007 |
The actions of azelnidipine, a dihydropyridine-derivative Ca antagonist, on voltage-dependent Ba2+ currents in guinea-pig vascular smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Azetidinecarboxylic Acid; Barium; Calcium Channel Blockers; Dihydropyridines; Female; Guinea Pigs; Ion Channel Gating; Male; Muscle, Smooth, Vascular | 2006 |
Switch between charge transfer and local excited states in 4-aminophenyl-substituted Hantzsch 1,4-dihydropyridine induced by pH change and transition metal ions.
Topics: Aminophenols; Cations; Dihydropyridines; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Metals; Spectrometry, Fluorescence | 2006 |
Physicochemical characteristics of novel P-glycoprotein inhibitors of the cage dimeric 1,4-dihydropyridine type.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Dihydropyridines; Dimerization; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Structure-Activity Relationship | 2006 |
Maturation of rat cerebellar Purkinje cells reveals an atypical Ca2+ channel current that is inhibited by omega-agatoxin IVA and the dihydropyridine (-)-(S)-Bay K8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebellar Cortex; Dihydropyridines; Male; Membrane Potentials; omega-Agatoxin IVA; Patch-Clamp Techniques; Purkinje Cells; Rats; Rats, Wistar | 2007 |
A convenient and efficient protocol for oxidative aromatization of Hantzsch 1,4-dihydropyridines using benzyltriphenylphosphonium peroxymonosulfate under almost neutral reaction conditions.
Topics: Acylation; Benzyl Compounds; Bismuth; Chromatography, Thin Layer; Cyclization; Dihydropyridines; Heterocyclic Compounds; Indicators and Reagents; Organophosphorus Compounds; Oxidation-Reduction | 2007 |
Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Calcium; Calcium Channels; Cell Proliferation; Cells, Cultured; Dihydropyridines; Eels; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Neuroblastoma; Neuroprotective Agents; Structure-Activity Relationship; Tacrine | 2006 |
G1 cell cycle arrest by amlodipine, a dihydropyridine Ca2+ channel blocker, in human epidermoid carcinoma A431 cells.
Topics: Amlodipine; Calcium Channel Blockers; Carcinoma, Squamous Cell; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinases; Dihydropyridines; G1 Phase; Humans; Nuclear Proteins; Phosphorylation; Repressor Proteins; Tumor Cells, Cultured | 2007 |
Analyses by GC-MS and GC-MS-MS of the Hantzsch synthesis products using hydroxy- and methoxy-aromatic aldehydes.
Topics: Aldehydes; Calcium Channel Blockers; Dihydropyridines; Gas Chromatography-Mass Spectrometry; Molecular Structure; Tandem Mass Spectrometry | 2007 |
Ultrasound-assisted photochemical oxidation of unsymmetrically substituted 1,4-dihydropyridines.
Topics: Chloroform; Chromatography, Thin Layer; Dihydropyridines; Oxidation-Reduction; Oxygen; Photochemistry; Ultrasonics; Ultraviolet Rays | 2008 |
One-step synthesis of heterocyclic privileged medicinal scaffolds by a multicomponent reaction of malononitrile with aldehydes and thiols.
Topics: Aldehydes; Chemistry, Organic; Combinatorial Chemistry Techniques; Dihydropyridines; Heterocyclic Compounds; Molecular Structure; Nitriles; Pyridines; Sulfhydryl Compounds; Technology, Pharmaceutical | 2007 |
Oxidation of C4-hydroxyphenyl 1,4-dihydropyridines in dimethylsulfoxide and its reactivity towards alkylperoxyl radicals in aqueous medium.
Topics: Dihydropyridines; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Free Radicals; Gas Chromatography-Mass Spectrometry; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Water | 2007 |
Oxidative aromatization of Hantzsch 1,4-dihydropyridines in the presence of mixed-addenda vanadomolybdophosphate heteropolyacid, H6PMo9V3O40.
Topics: Calcium Channel Blockers; Dihydropyridines; Humans; Hydrocarbons, Aromatic; Models, Chemical; Molybdenum; Organophosphorus Compounds; Oxidation-Reduction; Stereoisomerism; Vanadium Compounds | 2007 |
Structure-activity relationship of 1,4-dihydropyridines as potentiators of the cystic fibrosis transmembrane conductance regulator chloride channel.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chloride Channels; Cystic Fibrosis Transmembrane Conductance Regulator; Dihydropyridines; Rats; Rats, Inbred F344; Structure-Activity Relationship | 2007 |
Calcicludine binding to the outer pore of L-type calcium channels is allosterically coupled to dihydropyridine binding.
Topics: Alanine; Allosteric Regulation; Amino Acid Sequence; Amino Acid Substitution; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Disulfides; Elapid Venoms; Humans; Kinetics; Patch-Clamp Techniques | 2007 |
Autocrine activation of ion currents in the two-cell mouse embryo.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Autocrine Communication; Blastocyst; Calcium; Calcium Channel Blockers; Chorionic Gonadotropin; Dihydropyridines; Embryo, Mammalian; Female; Ion Transport; Membrane Potentials; Mice; Mice, Inbred C57BL; Platelet Activating Factor; Zygote | 2007 |
Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death.
Topics: Calcium; Calcium Channels; Cell Death; Cell Line, Tumor; Dihydropyridines; Humans; Hydrogen Peroxide; Lactic Acid; Neurons; Neuroprotective Agents; Oxidoreductases; Potassium | 2008 |
Evaluation of anticancer effects of newly synthesized dihydropyridine derivatives in comparison to verapamil and doxorubicin on T47D parental and resistant cell lines in vitro.
Topics: Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Proliferation; Dihydropyridines; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Inhibitory Concentration 50; Time Factors; Verapamil | 2008 |
Domino reaction of 3-(2-formylphenoxy)propenoates and amines: a novel synthesis of 1,4-dihydropyridines from salicaldehydes, ethyl propiolate, and amines.
Topics: Aldehydes; Alkynes; Amines; Aniline Compounds; Benzaldehydes; Dihydropyridines; Propionates | 2007 |
Synthesis, QSAR and calcium channel antagonist activity of new 1,4-dihydropyridine derivatives containing 1-methyl-4,5-dichloroimidazolyl substituents.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Models, Molecular; Molecular Structure; Muscle Contraction; Muscle, Smooth; Quantitative Structure-Activity Relationship; Spectrophotometry, Infrared | 2007 |
N-methyl-(R)-3-(tert-butyl)-sulfinyl-1,4-dihydropyridine: a novel NADH model compound.
Topics: Dihydropyridines; Models, Molecular; NAD; Sulfoxides | 2007 |
9-phenyl-10-methylacridinium: a highly efficient and reusable organocatalyst for mild aromatization of 1,4-dihydropyridines by molecular oxygen.
Topics: Acridines; Catalysis; Dihydropyridines; Molecular Structure; Oxygen; Perchlorates; Stereoisomerism | 2007 |
Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis.
Topics: Administration, Oral; Amlodipine; Animals; Antiprotozoal Agents; Dihydropyridines; Leishmania donovani; Leishmaniasis, Visceral; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Parasitic Sensitivity Tests; Treatment Outcome | 2008 |
Hantzsch synthesis of 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(o-methoxyphenyl)-1,4-dihydropyridine; a novel cyclisation leading to an unusual formation of 1-amino-2-methoxy-carbonyl-3,5-bis(o-methoxyphenyl)-4-oxa-cyclohexan-1-ene.
Topics: Crystallization; Cyclization; Cyclohexanes; Dihydropyridines; Molecular Structure | 2007 |
Calcium channels blockers and progression of kidney disease.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Disease Progression; Female; Humans; Kidney Diseases; Male; Middle Aged; Prospective Studies; Proteinuria | 2007 |
Relationship between lipophilicities of 1,4-dihydropyridine derivatives and pharmacokinetic interaction strengths with grapefruit juice.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Chemical Phenomena; Chemistry, Physical; Citrus paradisi; Dihydropyridines; Food-Drug Interactions; Humans; Structure-Activity Relationship | 2008 |
Inclusion of patients who overdose with dihydropyridine calcium channel blockers would potentially increase clinical utility of hyperglycemia.
Topics: Calcium Channel Blockers; Dihydropyridines; Diltiazem; Drug Overdose; Heart Rate; Humans; Hyperglycemia; Patient Selection; Verapamil | 2008 |
Analysis of dihydropyridine calcium channel blockers using negative ion photoionization mass spectrometry.
Topics: Calcium Channel Blockers; Dihydropyridines; Mass Spectrometry; Molecular Structure; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2008 |
A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity.
Topics: Adrenalectomy; Aldosterone; Animals; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Epithelial Sodium Channels; Male; Mineralocorticoid Receptor Antagonists; Models, Molecular; Mutation; Nimodipine; Protein Binding; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid | 2008 |
Synthesis of unsymmetrical substituted 1,4-dihydropyridines through thermal and microwave assisted [4+2] cycloadditions of 1-azadienes and allenic esters.
Topics: Alkadienes; Aza Compounds; Butadienes; Crystallography, X-Ray; Cyclization; Dihydropyridines; Esters; Hot Temperature; Microwaves; Models, Molecular; Molecular Conformation; Thermodynamics | 2008 |
Imidazo[2,1-b]thiazole system: a scaffold endowing dihydropyridines with selective cardiodepressant activity.
Topics: Animals; Binding Sites; Computer Simulation; Dihydropyridines; Drug Design; Drug Evaluation, Preclinical; Guinea Pigs; Heart; Heart Rate; Imidazoles; Ligands; Models, Molecular; Molecular Structure; Muscle, Smooth, Vascular; Myocardial Contraction; Myocytes, Cardiac; Small Molecule Libraries; Structure-Activity Relationship; Thiazoles | 2008 |
Structure-activity relationships of receptor binding of 1,4-dihydropyridine derivatives.
Topics: Animals; Binding Sites; Brain; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; KATP Channels; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Adrenergic; Receptors, Nicotinic; Receptors, Purinergic; Structure-Activity Relationship | 2008 |
Sulfonic acid functionalized silica: an efficient heterogeneous catalyst for a three-component synthesis of 1,4-dihydropyridines under solvent-free conditions.
Topics: Catalysis; Dihydropyridines; Esters; Indicators and Reagents; Silicon Dioxide; Solvents; Spectrometry, Mass, Fast Atom Bombardment; Sulfonic Acids | 2008 |
The solvent-free synthesis of 1,4-dihydropyridines under ultrasound irradiation without catalyst.
Topics: Catalysis; Chromatography, Liquid; Dihydropyridines; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Ultrasonics | 2008 |
A genetic screen for dihydropyridine (DHP)-resistant worms reveals new residues required for DHP-blockage of mammalian calcium channels.
Topics: Amino Acid Sequence; Animals; Caenorhabditis elegans; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Conserved Sequence; Dihydropyridines; Drug Evaluation, Preclinical; Drug Resistance; Electrophysiology; Models, Animal; Molecular Sequence Data; Mutation, Missense; Polymorphism, Genetic; Rats; Sequence Alignment | 2008 |
L-type Ca2+ channel function is linked to dystrophin expression in mammalian muscle.
Topics: Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Dystrophin; Female; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Microscopy, Confocal; Muscle Fibers, Skeletal; Muscular Dystrophy, Duchenne; Myosins; Signal Transduction | 2008 |
One-pot synthesis of highly functionalized pyridines via a rhodium carbenoid induced ring expansion of isoxazoles.
Topics: Dihydropyridines; Hot Temperature; Isoxazoles; Molecular Structure; Nitrogen; Oxygen; Pyridines; Rhodium | 2008 |
Dihydropiridine calcium-channel blockers and perioperative mortality in aortic aneurysm surgery.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Aortic Aneurysm; Calcium Channel Blockers; Dihydropyridines; Drug Administration Schedule; Epidemiologic Methods; Female; Humans; Hungary; Male; Middle Aged; Perioperative Care; Postoperative Complications | 2008 |
[Interaction of 1,4-dihydropyridines with ion channels].
Topics: Calcium Channel Blockers; Calcium Channels; Dihydropyridines | 2008 |
Dihydropyridine inhibition of the glycine receptor: subunit selectivity and a molecular determinant of inhibition.
Topics: Amino Acid Sequence; Analysis of Variance; Binding Sites; Biophysical Phenomena; Calcium Channel Blockers; Cell Line, Transformed; Dihydropyridines; Dose-Response Relationship, Drug; Electric Stimulation; GABA Antagonists; Humans; Membrane Potentials; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Picrotoxin; Protein Subunits; Receptors, Glycine; Sesterterpenes; Structure-Activity Relationship | 2009 |
The structure-activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Dihydropyridines; Humans; Rats; Solubility; Structure-Activity Relationship; Water | 2008 |
Calcium channel blockers, beta-blockers, and perioperative cardiovascular stability.
Topics: Adrenergic beta-Antagonists; Aortic Aneurysm; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Humans; Perioperative Care; Postoperative Complications | 2008 |
Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1).
Topics: Animals; Apraxia, Ideomotor; Cells, Cultured; Dihydropyridines; Ganglia, Spinal; Mice; Molecular Structure; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2008 |
A highly efficient biomimetic aromatization of Hantzsch-1,4-dihydropyridines with t-butylhydroperoxide, catalysed by iron(III) phthalocyanine chloride.
Topics: Biomimetic Materials; Catalysis; Chlorides; Dihydropyridines; Indoles; Iron Compounds; Isoindoles; Molecular Structure; Oxidants; Oxidation-Reduction; Solvents; tert-Butylhydroperoxide | 2008 |
Sustainable synthetic methods: domino construction of dihydropyridin-4-ones and beta-amino esters in aqueous ethanol.
Topics: Catalysis; Dihydropyridines; Esters; Ethanol; Green Chemistry Technology; Water | 2008 |
Calcium-channel blockers reduce the antiplatelet effect of clopidogrel.
Topics: Aged; Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Dihydropyridines; Drug Interactions; Female; Flow Cytometry; Humans; Logistic Models; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Reference Values; Risk Assessment; Sensitivity and Specificity; Statistics, Nonparametric; Ticlopidine; Treatment Outcome | 2008 |
Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms.
Topics: Amino Acid Motifs; Animals; Brain; Calcium Channels, L-Type; Dihydropyridines; Female; Gene Expression; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Isoforms | 2009 |
Differential sensitivities of CaV1.2 IIS5-S6 mutants to 1,4-dihydropyridine analogs.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Mutant Proteins; Nicardipine; Point Mutation; Protein Structure, Tertiary; Pyridines; Rats; Substrate Specificity | 2009 |
How to extend the use of grid-based interaction energy maps from chemistry to biotopics.
Topics: Amino Acid Substitution; Arylsulfotransferase; Bacillus anthracis; Computational Biology; Databases, Factual; Dihydropyridines; Models, Molecular; Mutagenesis, Site-Directed; Potassium Channels, Voltage-Gated; Protein Structure, Tertiary; Software; Sulfotransferases; Thermodynamics | 2009 |
1-Malonyl-1,4-dihydropyridine as a novel carrier for specific delivery of drugs to the brain.
Topics: Animals; Antidepressive Agents; Blood-Brain Barrier; Brain; Dihydropyridines; Drug Carriers; Drug Delivery Systems; Drug Stability; Isoniazid; Male; Malonates; Mice; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Rats, Wistar; Tissue Distribution | 2009 |
Evidence for regulation of mitochondrial function by the L-type Ca2+ channel in ventricular myocytes.
Topics: Actins; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocytes, Cardiac; NAD; Patch-Clamp Techniques; Potassium Chloride; Superoxides | 2009 |
Expression of voltage-activated calcium channels in the early zebrafish embryo.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Embryo, Nonmammalian; Embryonic Development; Gene Expression Regulation, Developmental; Ion Channel Gating; Zebrafish; Zebrafish Proteins | 2009 |
Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers.
Topics: Aged; Alleles; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Female; Humans; Hypertension; Male; Middle Aged; Polymorphism, Single Nucleotide | 2009 |
[Perspectives of inhibition of multidrug resistance during cancer chemotherapy, in vitro and in vivo experiments].
Topics: Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cytomegalovirus; Dihydropyridines; Disease Progression; Diterpenes; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; HSP90 Heat-Shock Proteins; Humans; Mice; Mice, Inbred DBA; Phenothiazines; Phenotype; Propylamines; Tylosin; Verapamil | 2009 |
The regio- and stereoselective synthesis of trans-2,3-dihydropyridine N-oxides and piperidines.
Topics: Dihydropyridines; Oxides; Piperidines; Stereoisomerism | 2009 |
Dihydropyridine- and voltage-sensitive Ca2+ entry in human parathyroid cells.
Topics: Barium; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Humans; Parathyroid Glands; Patch-Clamp Techniques | 2009 |
Isolation and pharmacological characterization of fatty acids from saw palmetto extract.
Topics: Animals; Calcium Channels; Cholestenone 5 alpha-Reductase; Chromatography, High Pressure Liquid; Dihydropyridines; Fatty Acids; Male; Plant Extracts; Prostatic Hyperplasia; Rats; Receptors, Adrenergic, alpha-1; Receptors, Muscarinic; Serenoa; Urologic Diseases | 2009 |
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Butyrylcholinesterase; Calcium; Calcium Channel Blockers; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytosol; Dihydropyridines; Humans; Hydrogen Peroxide; Kinetics; Ligands; Models, Molecular; Peptide Fragments; Permeability; Tacrine | 2009 |
Five different profiles of dihydropyridines in blocking T-type Ca(2+) channel subtypes (Ca(v)3.1 (alpha(1G)), Ca(v)3.2 (alpha(1H)), and Ca(v)3.3 (alpha(1I))) expressed in Xenopus oocytes.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Dihydropyridines; Dose-Response Relationship, Drug; Gene Expression; Humans; Membrane Potentials; Oocytes; Structure-Activity Relationship; Xenopus | 2009 |
Synthesis and docking studies of new 1,4-dihydropyridines containing 4-(5)-Chloro-2-ethyl-5-(4)-imidazolyl substituent as novel calcium channel agonist.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Binding Sites; Calcium Channel Agonists; Calcium Channels; Computer-Aided Design; Databases, Protein; Dihydropyridines; Drug Design; Ligands; Models, Molecular; Molecular Structure; Protein Conformation; Software; Structure-Activity Relationship | 2009 |
Structural model for dihydropyridine binding to L-type calcium channels.
Topics: Amino Acid Sequence; Binding Sites; Calcium; Calcium Channels, L-Type; Dihydropyridines; Hydrogen Bonding; Ions; Ligands; Models, Chemical; Molecular Conformation; Molecular Sequence Data; Monte Carlo Method; Protein Conformation; Structure-Activity Relationship; Tyrosine | 2009 |
Assessment and use of two silicon carbide multi-well plates for library synthesis and proteolytic digests using microwave heating.
Topics: Amines; Animals; Carbon Compounds, Inorganic; Cattle; Combinatorial Chemistry Techniques; Dihydropyridines; Equipment Design; Esters; Hydrocarbons, Aromatic; Insulin; Microwaves; Proteomics; Silicon Compounds; Small Molecule Libraries; Temperature; Trypsin | 2009 |
Oxidative aromatization of 1,4-dihydropyridines and pyrazolines using HbA-H(2)O(2): An efficient biomimetic catalyst system providing metabolites of drug candidates.
Topics: Animals; Biomimetics; Catalysis; Chemistry, Pharmaceutical; Cytochrome P-450 Enzyme System; Dihydropyridines; Drug Design; Heme; Hemoglobin A; Humans; Hydrogen Peroxide; Models, Chemical; Oxidation-Reduction; Oxygen; Phosphates; Pyrazoles | 2009 |
Synthesis of new tripodal Hantzsch 1,4-dihydropyridines under solvent-free condition and their conversion to the corresponding tripodal pyridines.
Topics: Catalysis; Cyclization; Dihydropyridines; Models, Biological; Molecular Conformation; Oxidation-Reduction; Pyridines; Solvents; Stereoisomerism | 2010 |
Dihydropyridine C-glycoconjugates by organocatalytic Hantzsch cyclocondensation. Stereoselective synthesis of alpha-threofuranose C-nucleoside enantiomers.
Topics: Aldehydes; Catalysis; Cyclization; Dihydropyridines; Glycoconjugates; Glycosylation; Molecular Structure; Nucleosides; Polysaccharides; Seaweed; Stereoisomerism; Tetroses | 2009 |
Effects of 5-acetyl(carbamoyl)-6-methylsulfanyl-1,4-dihydropyridine-5-carbonitriles on rat liver mitochondrial function.
Topics: Animals; Antioxidants; Dihydropyridines; Energy Metabolism; Male; Mitochondria, Liver; Nitriles; Oxidative Stress; Permeability; Rats; Rats, Wistar | 2009 |
Prediction of photosensitivity of 1,4-dihydropyridine antihypertensives by quantitative structure-property relationship.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Kinetics; Photolysis; Quantitative Structure-Activity Relationship; Spectrum Analysis | 2009 |
Exploring catalyst and solvent effects in the multicomponent synthesis of pyridine-3,5-dicarbonitriles.
Topics: Acetonitriles; Aldehydes; Amines; Catalysis; Dihydropyridines; Ethanol; Ions; Nitriles; Oxidants; Oxidation-Reduction; Oxygen; Pyridines; Pyridinium Compounds; Quaternary Ammonium Compounds; Solvents; Sulfhydryl Compounds | 2009 |
Aryl bridged 1-hydroxypyridin-2-one: effect of the bridge on the Eu(III) sensitization process.
Topics: Crystallography, X-Ray; Dihydropyridines; Europium; Hydrogen-Ion Concentration; Infrared Rays; Ligands; Luminescence; Molecular Structure; Spectrometry, Fluorescence | 2009 |
[H2O2 oxidation of 1,4-dihydropyridines over Mg2+ ion exchanged clinoptilolite and solventless solid state acid decomposition of ester to 3,5-pyridinedicarboxylic acid].
Topics: Cations, Divalent; Chemistry, Organic; Dihydropyridines; Esters; Hydrogen Peroxide; Ion Exchange; Magnesium; Organic Chemistry Phenomena; Oxidation-Reduction; Pyridines; Solvents; Zeolites | 2009 |
Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker.
Topics: Administration, Oral; Amines; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Cyclohexanecarboxylic Acids; Dihydropyridines; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Male; Models, Animal; Nifedipine; omega-Conotoxins; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 2009 |
L-proline-catalyzed synthesis of highly functionalized multisubstituted 1,4-dihydropyridines.
Topics: Catalysis; Crystallography, X-Ray; Dihydropyridines; Models, Molecular; Molecular Structure; Proline; Stereoisomerism | 2009 |
Synthesis and biological evaluation of N-aryl-1,4-dihydropyridines as novel antidyslipidemic and antioxidant agents.
Topics: Animals; Catalysis; Dihydropyridines; Free Radical Scavengers; Hypolipidemic Agents; Iodine; Lipids; Lipolysis; Male; Rats | 2010 |
Design, multicomponent synthesis, and bioactivities of novel neonicotinoid analogues with 1,4-dihydropyridine scaffold.
Topics: Animals; Aphids; Dihydropyridines; Insecticides; Magnetic Resonance Spectroscopy; Mass Spectrometry; Nicotine | 2010 |
Synthesis and biological activity of the calcium modulator (R) and (S)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.
Topics: Animals; Calcium; Calcium Channels, L-Type; Cerebral Cortex; Dicarboxylic Acids; Dihydropyridines; Myocardium; Protein Binding; Rats; Stereoisomerism | 2010 |
A region of N-type Ca(2+) channel critical for blockade by the dihydropyridine amlodipine.
Topics: Amino Acid Sequence; Amino Acid Substitution; Amlodipine; Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels, N-Type; Dihydropyridines; Dose-Response Relationship, Drug; Electrophysiology; Female; Lysine; Microelectrodes; Oocytes; Patch-Clamp Techniques; Xenopus | 2010 |
Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cell Membrane; Cerebral Arteries; Cerebrovascular Circulation; Dihydropyridines; Male; Myocytes, Smooth Muscle; Rats; Rats, Wistar; Vasoconstriction | 2010 |
Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with beta-amyloid, acetylcholine, and butyrylcholine esterases.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computer Simulation; Dihydropyridines; Kinetics; Models, Molecular; Structure-Activity Relationship | 2010 |
Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors.
Topics: Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cell Line; Dihydropyridines; Drug Design; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation | 2010 |
Flutamide inhibits nifedipine- and interleukin-1 beta-induced collagen overproduction in gingival fibroblasts.
Topics: Androgen Antagonists; Calcium Channel Blockers; Case-Control Studies; Cell Culture Techniques; Cells, Cultured; Collagen; Collagen Type I; Collagen Type I, alpha 1 Chain; Connective Tissue Growth Factor; Culture Media, Conditioned; Dihydropyridines; Drug Synergism; Female; Fibroblasts; Flutamide; Gingiva; Gingival Overgrowth; Humans; Interleukin-1beta; Male; Middle Aged; Nifedipine; Receptors, Androgen; Time Factors | 2010 |
Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Dicarboxylic Acids; Dihydropyridines; Humans; Inhibitory Concentration 50; Molecular Structure; Nifedipine | 2010 |
L-type calcium channel blockers and Parkinson disease in Denmark.
Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Community Health Planning; Denmark; Dihydropyridines; Female; Humans; Logistic Models; Male; Middle Aged; Outpatients; Parkinson Disease; Prescription Drugs; Registries; Retrospective Studies | 2010 |
PAC1hop receptor activation facilitates catecholamine secretion selectively through 2-APB-sensitive Ca(2+) channels in PC12 cells.
Topics: Animals; Boron Compounds; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Signaling; Cattle; Dihydropyridines; Inositol Phosphates; Norepinephrine; PC12 Cells; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Isoforms; Rats; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; Ryanodine | 2010 |
Facile and efficient aromatization of 1,4-dihydropyridines with M(NO3)2.XH2O, TNCB, TBAP and HMTAI and preparation of deuterium labeled dehydronifedipine from nifedipine-d3.
Topics: Calcium Channel Blockers; Deuterium; Dihydropyridines; Humans; Metals; Methenamine; Nifedipine; Nitrates; Quaternary Ammonium Compounds; Radiopharmaceuticals; Vasodilator Agents | 2010 |
Delayed diagnosis of primary hyperaldosteronism.
Topics: Adult; Aldosterone; Calcium Channel Blockers; Delayed Diagnosis; Dihydropyridines; Drug Resistance; Female; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Male; Middle Aged; Potassium; Renin | 2010 |
Synthesis and biological evaluation of novel hybrid chalcone derivatives as vasorelaxant agents.
Topics: Animals; Aorta; Chalcone; Dihydropyridines; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Vasodilator Agents | 2010 |
Synthesis of a library of 5,6-unsubstituted 1,4-dihydropyridines based on a one-pot 4CR/elimination process and their application to the generation of structurally diverse fused nitrogen heterocycles.
Topics: Aluminum Oxide; Catalysis; Combinatorial Chemistry Techniques; Dihydropyridines; Ethanol; Heterocyclic Compounds; Indium; Molecular Structure; Stereoisomerism | 2010 |
Novel structure-activity relationships and selectivity profiling of cage dimeric 1,4-dihydropyridines as multidrug resistance (MDR) modulators.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mice; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Structure-Activity Relationship | 2010 |
Ultrasound-enhanced one-pot synthesis of 3-(Het)arylmethyl-4-hydroxycoumarins in water.
Topics: Benzenesulfonates; Coumarins; Dihydropyridines; Sonication; Surface-Active Agents; Water | 2011 |
Insertion of pyridine into the calcium allyl bond: regioselective 1,4-dihydropyridine formation and C-H bond activation.
Topics: Allyl Compounds; Calcium; Dihydropyridines; Hydrogen Bonding; Molecular Structure; Organometallic Compounds; Pyridines; Stereoisomerism | 2010 |
Synthesis, structural and conformational properties, and gas phase reactivity of 1,4-dihydropyridine ester and ketone derivatives.
Topics: Crystallography, X-Ray; Dihydropyridines; Esters; Gases; Hydrogen Bonding; Ketones; Models, Molecular; Molecular Structure; Protons | 2010 |
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.
Topics: Animals; Biological Clocks; Brain; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Cyclophilins; Dihydropyridines; Dopamine; Gene Deletion; Ion Channels; Iridoid Glycosides; Iridoids; Male; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Proteins; Neurons; Oncogene Proteins; Oxidative Stress; Parkinson Disease; Peptidyl-Prolyl Isomerase F; Peroxiredoxins; Protein Deglycase DJ-1; Purines; Superoxides; Uncoupling Protein 1 | 2010 |
Catalytic asymmetric synthesis of both enantiomers of 4‑substituted 1,4-dihydropyridines with the use of bifunctional thiourea-ammonium salts bearing different counterions.
Topics: Aldehydes; Dihydropyridines; Molecular Structure; Quaternary Ammonium Compounds; Stereoisomerism; Thiourea | 2010 |
Identification of dihydropyridines that reduce cellular tau levels.
Topics: Cyclization; Dihydropyridines; Humans; Molecular Structure; Oxidation-Reduction; Stereoisomerism; Structure-Activity Relationship; tau Proteins; Tumor Cells, Cultured | 2011 |
Anti-breast cancer activity of some novel 1,2-dihydropyridine, thiophene and thiazole derivatives.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Dihydropyridines; Humans; Inhibitory Concentration 50; Structure-Activity Relationship; Thiazoles; Thiophenes | 2011 |
Brain-specific delivery of naproxen using different carrier systems.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Body Fluids; Brain; Cyclooxygenase Inhibitors; Dihydropyridines; Drug Carriers; Humans; Hydrolysis; Naproxen; Prodrugs; Solutions | 2010 |
Effect of a dihydropyridine-type calcium channel blocker on vascular remodeling after experimental balloon angioplasty.
Topics: Angioplasty, Balloon; Animals; Calcium Channel Blockers; Carotid Arteries; Carotid Artery Diseases; Carotid Artery Injuries; Cell Proliferation; Cholesterol, Dietary; Constriction, Pathologic; Dihydropyridines; Hyperplasia; Neointima; Rabbits; Tunica Intima | 2011 |
Synthesis and anticoagulant activity of a new series of 1,4-dihydropyridine derivatives.
Topics: Anticoagulants; Blood Coagulation; Dihydropyridines; Humans; Molecular Structure; Reference Values; Stereoisomerism | 2011 |
Comparative study of taurine and tauropyrone: GABA receptor binding, mitochondrial processes and behaviour.
Topics: Animals; Behavior, Animal; Bicuculline; Diazepam; Dihydropyridines; Energy Metabolism; Ethanol; Hydrophobic and Hydrophilic Interactions; Male; Mice; Mice, Inbred ICR; Mitochondria; Motor Activity; Muscle Tonus; Protein Binding; Rats; Rats, Wistar; Receptors, GABA-A; Rotarod Performance Test; Seizures; Structure-Activity Relationship; Taurine | 2011 |
Calcium inhibits dihydropyridine-stimulated increases in opening and unitary conductance of a plant Ca²+ channel.
Topics: Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; Lipid Bilayers; Membrane Potentials; Membranes, Artificial; Nicotinic Acids; Nifedipine; Oxadiazoles; Plant Roots; Triticum | 2011 |
Two 1,4-dihydropyridine derivatives with potential calcium-channel antagonist activity.
Topics: Calcium Channel Blockers; Crystallography, X-Ray; Cyclopentanes; Dihydropyridines; Hydrogen Bonding; Molecular Conformation; Molecular Structure; Pyridines; Stereoisomerism | 2011 |
Enantioselective organocatalytic aza-ene-type domino reaction leading to 1,4-dihydropyridines.
Topics: Aldehydes; Alkenes; Aza Compounds; Catalysis; Dihydropyridines; Stereoisomerism; Substrate Specificity | 2011 |
Synthesis, antibacterial and antimycobacterial activities of some new 4-aryl/heteroaryl-2,6-dimethyl-3,5-bis-N-(aryl)-carbamoyl-1,4-dihydropyridines.
Topics: Antitubercular Agents; Dihydropyridines; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Stereoisomerism; Structure-Activity Relationship | 2011 |
Application of electron conformational-genetic algorithm approach to 1,4-dihydropyridines as calcium channel antagonists: pharmacophore identification and bioactivity prediction.
Topics: Algorithms; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Drug Design; Electrons; Models, Chemical; Models, Theoretical; Molecular Conformation; Quantitative Structure-Activity Relationship; Receptors, Drug | 2012 |
Mechanism underlying the block of human Cav3.2 T-type Ca2+ channels by benidipine, a dihydropyridine Ca2+ channel blocker.
Topics: Calcium Channel Blockers; Calcium Channels, T-Type; Dihydropyridines; HEK293 Cells; Humans; Ion Channel Gating | 2011 |
Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier.
Topics: Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Dihydropyridines; Female; Humans; Memory; Mice; Peptide Fragments; Spatial Behavior; Transcytosis | 2011 |
New evidence of a dihydropyridine-activated cationic channel in the MDCK cell line.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cations; Cell Line; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Kidney; Membrane Potentials; Nifedipine | 2011 |
Asymmetric synthesis and biological evaluations of (+)- and (-)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels.
Topics: Animals; Calcium Channels, N-Type; Carboxylic Acids; Cell Line, Tumor; Dihydropyridines; Humans; Methyl Ethers; Molecular Structure; Protein Binding; Rats; Stereoisomerism; Structure-Activity Relationship | 2011 |
Molecular docking studies and in vitro screening of new dihydropyridine derivatives as human MRP1 inhibitors.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Insecta; Protein Binding | 2011 |
Tetrodotoxin-, dihydropyridine-, and riluzole-resistant persistent inward current: novel sodium channels in rodent spinal neurons.
Topics: Action Potentials; Animals; Animals, Newborn; Dihydropyridines; Mice; Mice, Transgenic; Motor Neurons; Rats; Rats, Sprague-Dawley; Riluzole; Sodium Channels; Spinal Cord; Tetrodotoxin | 2011 |
Growth modulation of human cells in vitro by mild oxidative stress and 1,4-dihydropyridine derivative antioxidants.
Topics: Aldehydes; Antioxidants; Cell Growth Processes; Cell Line, Tumor; Copper Sulfate; Dihydropyridines; Humans; Lipid Peroxidation; Oxidative Stress; Reactive Oxygen Species | 2011 |
Effect of 4-aryl-2-methyl-5-nitro-1,4-dihydropyridine-3-carboxylates on the guinea pig papillary muscle and isolated human vena saphena magna that is used for coronary artery bypass grafting.
Topics: Animals; Coronary Artery Bypass; Dihydropyridines; Guinea Pigs; Humans; In Vitro Techniques; Muscle, Smooth, Vascular; Saphenous Vein | 2011 |
Influence of dihydropyridine calcium antagonist nitrendipine on benzo(a)pyrene-induced oxidative stress.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Benzo(a)pyrene; Brain; Calcium Channel Blockers; Dihydropyridines; Glutathione; Hazardous Substances; Liver; Liver Function Tests; Lung; Male; Nitrendipine; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2011 |
Synthesis and biological evaluation of some novel N-aryl-1,4-dihydropyridines as potential antitubercular agents.
Topics: Antitubercular Agents; Chemistry Techniques, Synthetic; Dihydropyridines; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Stereoisomerism; Structure-Activity Relationship | 2011 |
Distinct properties of amlodipine and nicardipine block of the voltage-dependent Ca2+ channels Cav1.2 and Cav2.1 and the mutant channels Cav1.2/dihydropyridine insensitive and Cav2.1/dihydropyridine sensitive.
Topics: Amino Acid Sequence; Amlodipine; Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Dihydropyridines; HEK293 Cells; Humans; Molecular Sequence Data; Mutation; Nicardipine; Protein Conformation | 2011 |
Intramolecular C-H···O hydrogen bonding in 1,4-dihydropyridine derivatives.
Topics: Dihydropyridines; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Conformation; Structure-Activity Relationship | 2011 |
[4 + 2] Cyclocondensation reactions of tungsten-dihydropyridine complexes and the generation of tri- and tetrasubstituted piperidines.
Topics: Cyclization; Dihydropyridines; Molecular Structure; Organometallic Compounds; Piperidines; Stereoisomerism; Tungsten | 2011 |
Hantzsch reaction: synthesis and characterization of some new 1,4-dihydropyridine derivatives as potent antimicrobial and antioxidant agents.
Topics: Animals; Anti-Infective Agents; Bacteria; Behavior, Animal; Biphenyl Compounds; Chemistry Techniques, Synthetic; Dihydropyridines; Female; Free Radical Scavengers; Fungi; Mice; Picrates | 2011 |
Design and synthesis of some novel hydrazide, 1,2-dihydropyridine, chromene derivatives carrying biologically active sulfone moieties with potential anticancer activity.
Topics: Antineoplastic Agents; Benzopyrans; Breast Neoplasms; Cell Line, Tumor; Dihydropyridines; Drug Design; Drug Screening Assays, Antitumor; Female; Humans; Hydrazines; Indicators and Reagents; Magnetic Resonance Spectroscopy; Spectrophotometry, Infrared; Structure-Activity Relationship; Sulfones | 2011 |
Calcium channel antagonist exposures reported to the Poisons Information Center Erfurt.
Topics: Adolescent; Adult; Age Distribution; Aged; Calcium Channel Blockers; Child; Dihydropyridines; Diltiazem; Drug Overdose; Drug Synergism; Germany; Humans; Infant; Middle Aged; Poison Control Centers; Retrospective Studies; Verapamil; Young Adult | 2011 |
Synthesis of 5-alkylated barbituric acids and 3-alkylated indoles via microwave-assisted three-component reactions in solvent-free conditions using Hantzsch 1,4-dihydropyridines as reducing agents.
Topics: Alkylation; Barbiturates; Dihydropyridines; Indoles; Microwaves; Oxidation-Reduction | 2012 |
Dihydropyridine calcium channel blockers and the progression of parkinsonism.
Topics: Aged; Aged, 80 and over; Calcium Channel Blockers; Cohort Studies; Dihydropyridines; Disease Progression; Female; Humans; Hypertension; Male; Parkinsonian Disorders; Retrospective Studies | 2012 |
How do dihydropyridine and nondihydropyridine CCBs differ?
Topics: Calcium Channel Blockers; Dihydropyridines; Drug Interactions; Heart Conduction System; Humans; Nifedipine | 2012 |
Nitric oxide inhibits androgen receptor-mediated collagen production in human gingival fibroblasts.
Topics: Aged; Case-Control Studies; Cells, Cultured; Collagen Type I; Dihydropyridines; Fibroblasts; Gingiva; Gingival Overgrowth; Humans; Interleukin-1beta; Middle Aged; Nifedipine; Nitric Oxide; Nitric Oxide Synthase Type II; Receptors, Androgen; Statistics, Nonparametric | 2012 |
Remarkably fast and selective aromatization of Hantzsch esters with MoOCl4 and MoCl5: a chemical model for possible biologically relevant properties of molybdenum-containing enzymes.
Topics: Aldehyde Oxidase; Chlorides; Dihydropyridines; Esters; Models, Chemical; Molybdenum; Xanthine Oxidase | 2012 |
Discovery and evaluation of selective N-type calcium channel blockers: 6-unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives.
Topics: Administration, Oral; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Carboxylic Acids; Dihydropyridines; Drug Evaluation, Preclinical; Formaldehyde; Pain Measurement; Rats; Structure-Activity Relationship | 2012 |
Facile photoreduction of graphene oxide by an NAD(P)H model: Hantzsch 1,4-dihydropyridine.
Topics: Dihydropyridines; Graphite; Models, Molecular; NADP; Oxides; Particle Size; Photochemical Processes; Surface Properties | 2012 |
Elucidating the pre- and post-nuclear intracellular processing of 1,4-dihydropyridine based gene delivery carriers.
Topics: Biological Transport; Cell Line; Cell Nucleolus; Dihydropyridines; DNA; Endocytosis; Endosomes; Gene Expression; Gene Transfer Techniques; Humans; Plasmids; Retinal Pigment Epithelium; RNA, Messenger; Transfection; Transgenes | 2012 |
Enantiomeric recognition of racemic 4-aryl-1,4-dihydropyridine derivatives via chiralpak AD-H stationary phases.
Topics: Amylose; Dihydropyridines; Hydrogen Bonding; Methylation; Molecular Structure; Phenylcarbamates; Stereoisomerism | 2012 |
Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells.
Topics: Animals; Cell Differentiation; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Down-Regulation; Embryonic Stem Cells; Epidermal Growth Factor; HEK293 Cells; Humans; Membrane Glycoproteins; Mice; Mice, Knockout; Molecular Weight; Myocytes, Cardiac; Neoplasm Proteins; Protein Serine-Threonine Kinases; Proteolysis; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Structure-Activity Relationship | 2012 |
Diversity-oriented synthesis of 1-substituted 4-aryl-6-oxo-1,6-dihydropyridine-3-carboxamides.
Topics: Amides; Carboxylic Acids; Combinatorial Chemistry Techniques; Cyclization; Dihydropyridines | 2012 |
Ligand-based design, in silico ADME-Tox filtering, synthesis and biological evaluation to discover new soluble 1,4-DHP-based CFTR activators.
Topics: Absorption; Animals; Calcium Channel Blockers; Chemistry Techniques, Synthetic; Computational Biology; Cystic Fibrosis Transmembrane Conductance Regulator; Dihydropyridines; Drug Design; Humans; Ligands; Models, Molecular; Mutation; Protein Conformation; Quantitative Structure-Activity Relationship; Rats; Solubility | 2012 |
Design, solvent free synthesis, and antimicrobial evaluation of 1,4 dihydropyridines.
Topics: Anti-Bacterial Agents; Dihydropyridines; Dose-Response Relationship, Drug; Drug Design; Escherichia coli; Hydrogen Bonding; Klebsiella pneumoniae; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2012 |
Genotoxic and antigenotoxic assessment of four newly synthesized dihydropyridine derivatives.
Topics: Aminacrine; Dihydropyridines; Escherichia coli; Methylnitronitrosoguanidine; Mutagenicity Tests; Mutagens; Salmonella typhimurium | 2014 |
A facile four component protocol for the synthesis of dihydropyridine derivatives.
Topics: Alkadienes; Aniline Compounds; Dihydropyridines; Models, Molecular; Molecular Structure; Stereoisomerism | 2012 |
Benidipine persistently inhibits delayed rectifier K(+)-channel currents in murine thymocytes.
Topics: Animals; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Kv1.3 Potassium Channel; Male; Membrane Potentials; Mice; Nifedipine; Thymocytes | 2013 |
Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling.
Topics: Activins; Animals; Calcium; Cell Differentiation; Cells, Cultured; Dihydropyridines; Embryonic Stem Cells; Humans; Mice; Molecular Structure; Myocytes, Cardiac; Protein Binding; Protein Serine-Threonine Kinases; Quinolones; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta | 2012 |
Biological activities of eco-friendly synthesized Hantzsch adducts.
Topics: Antineoplastic Agents; Catalysis; Cell Line, Tumor; Cell Proliferation; Citric Acid; Dihydropyridines; Free Radical Scavengers; Humans; Lactic Acid; Molecular Structure; Reactive Nitrogen Species; Reactive Oxygen Species | 2013 |
Development of small-molecule P-gp inhibitors of the N-benzyl 1,4-dihydropyridine type: novel aspects in SAR and bioanalytical evaluation of multidrug resistance (MDR) reversal properties.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Survival; Daunorubicin; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mice; Neoplasms; Structure-Activity Relationship | 2013 |
SMILES-based QSAR models for the calcium channel-antagonistic effect of 1,4-dihydropyridines.
Topics: Calcium Channel Blockers; Dihydropyridines; Drug Design; Models, Chemical; Molecular Structure; Monte Carlo Method; Reproducibility of Results; Software; Structure-Activity Relationship | 2013 |
Discovery of novel 1,4-dihydropyridine-based PDE4 inhibitors.
Topics: Crystallography, X-Ray; Dihydropyridines; Drug Discovery; Phosphodiesterase 4 Inhibitors; Structure-Activity Relationship | 2013 |
Bilayer properties of giant magnetic liposomes formed by cationic pyridine amphiphile and probed by active deformation under magnetic forces.
Topics: Dihydropyridines; Hydrophobic and Hydrophilic Interactions; Lipid Bilayers; Liposomes; Magnetic Fields; Mechanical Phenomena | 2013 |
Detection of dihydropyridine- and voltage-sensitive intracellular Ca(2+) signals in normal human parathyroid cells.
Topics: Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Signaling; Dihydropyridines; Humans; Nicardipine; Parathyroid Glands | 2013 |
Characterization of the anxiolytic and sedative profile of JM-20: a novel benzodiazepine-dihydropyridine hybrid molecule.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Diazepam; Dihydropyridines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Female; Hypnotics and Sedatives; Male; Mice; Niacin; Rats | 2013 |
Antagonism of L-type Ca2+ channels CaV1.3 and CaV1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics.
Topics: Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; HEK293 Cells; Humans; Inhibitory Concentration 50; Molecular Mimicry; Molecular Structure; Protein Binding; Pyrans | 2013 |
15N NMR of 1,4-dihydropyridine derivatives.
Topics: Dihydropyridines; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Quantum Theory | 2013 |
Synthesis, antibacterial and antifungal evaluation of novel 1,4-dihydropyridine derivatives.
Topics: Anti-Bacterial Agents; Antifungal Agents; Bacteria; Cyclohexanones; Dihydropyridines; Fungi; Microbial Sensitivity Tests; Oxazoles | 2013 |
Effect of bis-1,4-dihydropyridine in the kidney of diabetic rats.
Topics: Albuminuria; Animals; Body Weight; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dihydropyridines; In Vitro Techniques; Kidney; Male; Organ Size; Perfusion; Proteinuria; Rats; Rats, Wistar; Streptozocin; Vasodilation | 2013 |
Multicomponent synthesis of antibacterial dihydropyridin and dihydropyran embelin derivatives.
Topics: Anti-Bacterial Agents; Benzoquinones; Dihydropyridines; Molecular Structure; Pyrans; Stereoisomerism | 2013 |
Ruthenium-catalyzed transfer-hydrogenative cyclization of 1,6-diynes with hantzsch 1,4-dihydropyridine as a H2 surrogate.
Topics: Catalysis; Cyclization; Cycloparaffins; Dihydropyridines; Diynes; Hydrogenation; Molecular Structure; Organometallic Compounds; Ruthenium | 2013 |
C-terminal alternative splicing of CaV1.3 channels distinctively modulates their dihydropyridine sensitivity.
Topics: Alternative Splicing; Animals; Brain Chemistry; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; HEK293 Cells; Humans; Protein Isoforms; Rats | 2013 |
Rate-dependent Ca2+ signalling underlying the force-frequency response in rat ventricular myocytes: a coupled electromechanical modeling study.
Topics: Animals; Biomechanical Phenomena; Calcineurin; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Cyclic AMP; Cyclic GMP; Dihydropyridines; Electrophysiological Phenomena; Heart Ventricles; Intracellular Space; Kinetics; Models, Biological; Myocardial Contraction; Myocytes, Cardiac; Rats; Receptors, Adrenergic, beta; Ryanodine Receptor Calcium Release Channel; Sarcomeres; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction | 2013 |
Small molecules intercept Notch signaling and the early secretory pathway.
Topics: Amyloid Precursor Protein Secretases; Animals; Dihydropyridines; Endoplasmic Reticulum; Golgi Apparatus; HeLa Cells; Humans; Molecular Structure; Receptors, Notch; Secretory Pathway; Signal Transduction; Structure-Activity Relationship; Zebrafish | 2013 |
Synthesis and evaluation of 1,4-dihydropyridine derivatives with calcium channel blocking activity.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; HEK293 Cells; Humans; Rats; Structure-Activity Relationship | 2014 |
Synthesis and antimicrobial activity of some novel hydrazide, benzochromenone, dihydropyridine, pyrrole, thiazole and thiophene derivatives.
Topics: Anti-Bacterial Agents; Antifungal Agents; Benzopyrans; Candida albicans; Dihydropyridines; Dose-Response Relationship, Drug; Escherichia coli; Hydrazones; Microbial Sensitivity Tests; Molecular Structure; Pyrroles; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Thiophenes | 2013 |
Evidence-based triple antihypertensive therapy yields lower mortality in older patients with diabetes mellitus.
Topics: Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dihydropyridines; Drug Combinations; Female; Gliclazide; Humans; Hypertension; Indapamide; Male; Perindopril | 2014 |
JM-20, a novel benzodiazepine–dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro.
Topics: Animals; Benzodiazepines; Brain Ischemia; Calcium; Cell Death; Cerebellum; Cytochromes c; Dihydropyridines; Glutamic Acid; Hydrogen Peroxide; Hydrolysis; Liver; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Proton-Translocating ATPases; Mitochondrial Swelling; Neurons; Neuroprotective Agents; Niacin; Oxidative Stress; PC12 Cells; Pentylenetetrazole; Phosphates; Potassium Cyanide; Rats; Stroke | 2014 |
Synthesis and 3D-QSAR study of 1,4-dihydropyridine derivatives as MDR cancer reverters.
Topics: Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Quantitative Structure-Activity Relationship | 2014 |
Urban-rural disparity of generics prescription in Taiwan: the example of dihydropyridine derivatives.
Topics: Calcium Channel Blockers; Dihydropyridines; Drugs, Generic; Healthcare Disparities; Humans; Prescription Drugs; Rural Health Services; Taiwan; Urban Health Services | 2014 |
Inhibitors of Alzheimer's BACE-1 with 3,5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridine structure.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Crystallography, X-Ray; Dihydropyridines; Enzyme Inhibitors; Humans; Structure-Activity Relationship | 2015 |
The rational design of a highly sensitive and selective fluorogenic probe for detecting nitric oxide.
Topics: Animals; Cell Line, Tumor; Coumarins; Dihydropyridines; Electron Transport; Fluorescent Dyes; Hydrogen-Ion Concentration; Mice; Microscopy, Fluorescence; Niacin; Nitric Oxide; Reactive Nitrogen Species; Reactive Oxygen Species; Spectrometry, Fluorescence | 2014 |
Glechoma hederacea Suppresses RANKL-mediated Osteoclastogenesis.
Topics: Acid Phosphatase; Animals; Bone Marrow Cells; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cell Differentiation; Cells, Cultured; Cytosol; Dihydropyridines; Dose-Response Relationship, Drug; Giant Cells; Isoenzymes; Lamiaceae; Macrophages; Mice; Mice, Inbred C57BL; NFATC Transcription Factors; Osteoclasts; Plant Extracts; RANK Ligand; Tartrate-Resistant Acid Phosphatase | 2014 |
1,4-Dihydropyridine derivatives with T-type calcium channel blocking activity attenuate inflammatory and neuropathic pain.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cell Line; Dihydropyridines; Humans; Inflammation; Ion Channel Gating; Mice; Mice, Inbred C57BL; Neuralgia; Small Molecule Libraries | 2015 |
Batch and continuous flow preparation of Hantzsch 1,4-dihydropyridines under microwave heating and simultaneous real-time monitoring by Raman spectroscopy. An exploratory study.
Topics: Dihydropyridines; Heating; Hot Temperature; Microwaves; Solvents; Spectrum Analysis, Raman | 2014 |
DNA-binding studies of AV-153, an antimutagenic and DNA repair-stimulating derivative of 1,4-dihydropiridine.
Topics: Animals; Antimutagenic Agents; Binding Sites; Dihydropyridines; DNA; DNA Repair; Liver; Molecular Structure; Niacin; Rats; Spectroscopy, Fourier Transform Infrared | 2014 |
Development of dual inhibitors against Alzheimer's disease using fragment-based QSAR and molecular docking.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Binding Sites; Combinatorial Chemistry Techniques; Dihydropyridines; GPI-Linked Proteins; Humans; Models, Molecular; Molecular Docking Simulation; Protein Binding; Quantitative Structure-Activity Relationship | 2014 |
Copper-mediated hydroxylation of arenes and heteroarenes directed by a removable bidentate auxiliary.
Topics: Benzamides; Benzene Derivatives; Catalysis; Copper; Dihydropyridines; Hydroxylation; Ligands; Molecular Structure; Phenols | 2014 |
Lewis acid catalysis and Green oxidations: sequential tandem oxidation processes induced by Mn-hyperaccumulating plants.
Topics: Acyclic Monoterpenes; Alcohols; Aldehydes; Biodegradation, Environmental; Catalysis; Cymenes; Dihydropyridines; Gas Chromatography-Mass Spectrometry; Green Chemistry Technology; Hydrogen-Ion Concentration; Ketones; Lewis Acids; Magnetic Resonance Spectroscopy; Magnoliopsida; Manganese; Monoterpenes; New Caledonia; Oxidation-Reduction | 2015 |
Synthesis and evaluation of novel triazoles and mannich bases functionalized 1,4-dihydropyridine as angiotensin converting enzyme (ACE) inhibitors.
Topics: Angiotensin-Converting Enzyme Inhibitors; Cell Line, Tumor; Cell Survival; Dihydropyridines; Enzyme Activation; HEK293 Cells; Humans; Mannich Bases; Peptidyl-Dipeptidase A; Protein Binding; Triazoles | 2014 |
Oxidative activation of dihydropyridine amides to reactive acyl donors.
Topics: Amides; Biomimetics; Dihydropyridines; Oxidation-Reduction; Phenethylamines | 2015 |
Basal and β-adrenergic regulation of the cardiac calcium channel CaV1.2 requires phosphorylation of serine 1700.
Topics: Adaptation, Physiological; Adrenergic beta-Agonists; Amino Acid Substitution; Animals; Arrhythmias, Cardiac; Barium; Calcium; Calcium Channels, L-Type; Cardiomyopathy, Hypertrophic; Casein Kinase II; Dihydropyridines; Exercise Tolerance; Heart Failure; Ion Transport; Isoproterenol; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Models, Molecular; Mutation, Missense; Myocardial Contraction; Myocytes, Cardiac; Phosphorylation; Phosphoserine; Point Mutation; Protein Conformation; Protein Processing, Post-Translational; Receptors, Adrenergic, beta; Signal Transduction; Transfection | 2014 |
Cytotoxic and multidrug resistance reversal activities of novel 1,4-dihydropyridines against human cancer cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Calcium Channels; Cell Line, Tumor; Dihydropyridines; Doxorubicin; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; Molecular Structure; Neoplasm Proteins; Neoplasms; Stereoisomerism; Structure-Activity Relationship | 2015 |
Design, Synthesis, and Biological Evaluation of 1,4-dihydropyridine Derivatives as Potent Antitubercular Agents.
Topics: Animals; Antitubercular Agents; Chlorocebus aethiops; Dihydropyridines; Drug Design; Imidazoles; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Structure-Activity Relationship; Vero Cells | 2015 |
The novel synthesis of magnetically chitosan/carbon nanotube composites and their catalytic applications.
Topics: Catalysis; Chitosan; Dihydropyridines; Magnetic Phenomena; Magnetometry; Nanocomposites; Nanotubes, Carbon; Solvents; Spectrometry, X-Ray Emission; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; Vibration; X-Ray Diffraction | 2015 |
Glucopyranosyl-1,4-dihydropyridine as a new fluorescent chemosensor for selective detection of 2,4,6-trinitrophenol.
Topics: Dihydropyridines; Environmental Monitoring; Fluorescent Dyes; Glucosides; Limit of Detection; Picrates; Rivers; Seawater; Spectrometry, Fluorescence; Water Pollutants, Chemical | 2015 |
One-pot multi-component synthesis of 1,4-dihydropyridines using Zn(2+) @KSF and evaluating their antibacterial and antioxidant activities.
Topics: Anti-Bacterial Agents; Antioxidants; Ascorbic Acid; Bacteria; Biphenyl Compounds; Carbon-13 Magnetic Resonance Spectroscopy; Catalysis; Dihydropyridines; Disk Diffusion Antimicrobial Tests; Drug Design; Green Chemistry Technology; Molecular Structure; Picrates; Proton Magnetic Resonance Spectroscopy; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Zinc | 2015 |
Bio-activation of 4-alkyl analogs of 1,4-dihydropyridine mediated by cytochrome P450 enzymes.
Topics: Biocatalysis; Cytochrome P-450 Enzyme System; Dihydropyridines; Molecular Structure; Quantum Theory | 2015 |
Trends in the precipitation and crystallization behavior of supersaturated aqueous solutions of poorly water-soluble drugs assessed using synchrotron radiation.
Topics: Calcium Channel Blockers; Chemical Precipitation; Crystallization; Dihydropyridines; Hydrophobic and Hydrophilic Interactions; Polymers; Solubility; Solutions; Synchrotrons; Water; X-Ray Diffraction | 2015 |
Design, synthesis and 3D-QSAR studies of novel 1,4-dihydropyridines as TGFβ/Smad inhibitors.
Topics: Chemistry Techniques, Synthetic; Dihydropyridines; Drug Design; HEK293 Cells; Humans; Models, Molecular; Protein Conformation; Quantitative Structure-Activity Relationship; Smad Proteins; Transforming Growth Factor beta | 2015 |
Hantzsch dihydropyridines: Privileged structures for the formation of well-defined gold nanostars.
Topics: Dihydropyridines; Gold; Nanostructures; Nanotechnology; Reducing Agents | 2015 |
A Novel 1,4-Dihydropyridine Derivative Improves Spatial Learning and Memory and Modifies Brain Protein Expression in Wild Type and Transgenic APPSweDI Mice.
Topics: Amyloid beta-Peptides; Animals; Anti-Anxiety Agents; Blood-Brain Barrier; Brain; Carrier Proteins; Dihydropyridines; Glutamate Decarboxylase; Gyrus Cinguli; Hippocampus; Homer Scaffolding Proteins; Humans; Male; Memory; Mice, Inbred C57BL; Mice, Transgenic; Spatial Learning; Time Factors | 2015 |
Management of periodontal disease in patients using calcium channel blockers - gingival overgrowth, prescribed medications, treatment responses and added treatment costs.
Topics: Adult; Aged; Aged, 80 and over; Calcium Channel Blockers; Chronic Periodontitis; Dihydropyridines; Drug Combinations; Drug Substitution; Female; Follow-Up Studies; Gingival Overgrowth; Health Care Costs; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Oral Hygiene; Recurrence; Renin-Angiotensin System; Retreatment; Tooth Loss; Treatment Outcome | 2015 |
Expedient Access to 2,3-Dihydropyridines from Unsaturated Oximes by Rh(III)-Catalyzed C-H Activation.
Topics: Alkenes; Catalysis; Dihydropyridines; Hydrogenation; Oximes; Rhodium; Stereoisomerism | 2015 |
Activation of the phosphatidylinositol 3-kinase pathway plays important roles in reduction of cerebral infarction by cilnidipine.
Topics: Animals; Brain; Cerebral Infarction; Dihydropyridines; Disease Models, Animal; Hypertension; Male; Phosphatidylinositol 3-Kinases; Rats, Sprague-Dawley; Signal Transduction | 2015 |
Molecular simulations study of novel 1,4-dihydropyridines derivatives with a high selectivity for Cav3.1 calcium channel.
Topics: Calcium Channels, T-Type; Dihydropyridines; Drug Discovery; Humans; Molecular Dynamics Simulation | 2015 |
Analgesic effect of a broad-spectrum dihydropyridine inhibitor of voltage-gated calcium channels.
Topics: Analgesics; Animals; Calcium Channel Blockers; Calcium Channels; Cell Line; Dihydropyridines; Humans; Neuralgia; Rats | 2015 |
Synthesis and Cytotoxic Evaluation of Pyran, Dihydropyridine and Thiophene Derivatives of 3-Acetylcoumarin.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Coumarins; Dihydropyridines; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Pyrans; Structure-Activity Relationship; Thiophenes | 2015 |
New Organocatalytic Asymmetric Synthesis of Highly Substituted Chiral 2-Oxospiro-[indole-3,4'- (1',4'-dihydropyridine)] Derivatives.
Topics: Catalysis; Dihydropyridines; Indoles; Molecular Structure; Spiro Compounds; Stereoisomerism | 2015 |
Relationship between calcium channel blocker class and mortality in dialysis.
Topics: Calcium Channel Blockers; Cohort Studies; Comorbidity; Dihydropyridines; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Medicaid; Medicare; Middle Aged; Renal Dialysis; Retrospective Studies; Survival Analysis; United States | 2015 |
Synthesis of ent-ketorfanol via a C-H alkenylation/torquoselective 6π electrocyclization cascade.
Topics: Alkenes; Analgesics, Opioid; Catalysis; Cyclization; Dihydropyridines; Models, Molecular; Oxidation-Reduction; Rhodium; Stereoisomerism | 2015 |
Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates.
Topics: Amines; Carboxylic Acids; Catalysis; Dihydropyridines; Esters; Solvents | 2015 |
Photodegradation studies of 1,4-dihydropyridine compounds by MCR analysis on UV spectral data.
Topics: Dihydropyridines; Drug Stability; Kinetics; Light; Photolysis; Spectrophotometry, Ultraviolet | 2016 |
Multicomponent Reactions of Acetoacetanilide Derivatives with Aromatic Aldehydes and Cyanomethylene Reagents to Produce 4H-Pyran and 1,4-Dihydropyridine Derivatives with Antitumor Activities.
Topics: Acetanilides; Aldehydes; Antineoplastic Agents; Cell Proliferation; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fibroblasts; Humans; Hydrocarbons, Aromatic; Molecular Structure; Nitriles; Pyrans; Structure-Activity Relationship | 2015 |
1,4-Dihydropyridine derivatives without Ca2+-antagonist activity up-regulate Psma6 mRNA expression in kidneys of intact and diabetic rats.
Topics: Animals; Diabetes Mellitus, Type 1; Dihydropyridines; Female; Humans; Kidney; Male; Proteasome Endopeptidase Complex; Rats; Up-Regulation | 2016 |
New 1,4-Dihydropyridines Down-regulate Nitric Oxide in Animals with Streptozotocin-induced Diabetes Mellitus and Protect Deoxyribonucleic Acid against Peroxynitrite Action.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dihydropyridines; DNA; Down-Regulation; Kidney; Liver; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Protective Agents; Rats; Rats, Wistar; Reactive Nitrogen Species; Reactive Oxygen Species; Xanthine Dehydrogenase | 2016 |
Binding mechanisms of 1,4-dihydropyridine derivatives to L-type calcium channel Cav1.2: a molecular modeling study.
Topics: Amino Acid Sequence; Binding Sites; Calcium Channels, L-Type; Dihydropyridines; Humans; Hydrogen Bonding; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Protein Structure, Secondary; Structural Homology, Protein; Thermodynamics | 2016 |
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Dihydropyridines; Enzyme Activation; Humans; Male; Mice; Mitochondria; Neoplasms; Signal Transduction; Sirtuin 1; Skin; Wound Healing | 2016 |
Synthesis and Utility of Dihydropyridine Boronic Esters.
Topics: Boronic Acids; Dihydropyridines; Esters; Molecular Structure; Quantum Theory | 2016 |
Repetition priming-induced changes in sensorimotor transmission.
Topics: Action Potentials; Animals; Aplysia; Calcium; Calcium Channel Blockers; Dihydropyridines; Ganglia, Invertebrate; Long-Term Potentiation; Motor Neurons; Neurons, Afferent; Neuropeptides; Nifedipine; Repetition Priming; Synaptic Transmission | 2016 |
Synthesis, Evaluation of Pharmacological Activity, and Molecular Docking of 1,4-Dihydropyridines as Calcium Antagonists.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Male; Molecular Docking Simulation; Nifedipine; Proton Magnetic Resonance Spectroscopy | 2016 |
In search of the mutual relationship between the structure, solid-state spectroscopy and molecular dynamics in selected calcium channel blockers.
Topics: Calcium Channel Blockers; Crystallization; Dihydropyridines; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Nifedipine; Nimodipine; Nitrendipine; Quantum Theory; Spectrophotometry, Infrared; X-Ray Diffraction | 2016 |
Photostabilization studies of antihypertensive 1,4-dihydropyridines using polymeric containers.
Topics: Antihypertensive Agents; Dihydropyridines; Drug Packaging; Drug Stability; Drug Storage; Felodipine; Glass; Light; Pharmaceutical Solutions; Photolysis; Polyethylene Terephthalates; Polymers; Time Factors | 2016 |
Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Cell Line, Tumor; Dendritic Spines; Dihydropyridines; Disease Models, Animal; Gene Expression Regulation; Heat-Shock Proteins; Humans; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neuroblastoma; Neuroprotective Agents; Presenilin-1; tau Proteins | 2016 |
Enantioselective N-heterocyclic carbene-catalyzed synthesis of saccharine-derived dihydropyridinones with cis-selectivity.
Topics: Catalysis; Cyclization; Dihydropyridines; Methane; Saccharin; Stereoisomerism | 2016 |
Memory-enhancing and brain protein expression-stimulating effects of novel calcium antagonist in Alzheimer's disease transgenic female mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Anxiety Agents; Blood-Brain Barrier; Calcium; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Female; GABAergic Neurons; Glutamate Decarboxylase; Gyrus Cinguli; Hippocampus; Male; Maze Learning; Memory; Mice; Mice, Transgenic; Neuronal Plasticity; Up-Regulation; Vesicular Inhibitory Amino Acid Transport Proteins | 2016 |
Photochemistry of 1,4-Dihydropyridine Derivatives: Diradical Formation, Delocalization and Trapping as a Route to Novel Tricyclic and Tetracyclic Nitrogen Heterocyclic Ring Systems.
Topics: Crystallography, X-Ray; Cycloaddition Reaction; Dihydropyridines; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 4 or More Rings; Models, Molecular; Molecular Structure; Nitrogen; Photochemical Processes; Photochemistry | 2016 |
Enantioselective isothiourea-catalysed trans-dihydropyridinone synthesis using saccharin-derived ketimines: scope and limitations.
Topics: Catalysis; Chemistry Techniques, Synthetic; Dihydropyridines; Imines; Nitriles; Saccharin; Stereoisomerism; Thiourea | 2016 |
Pilot Trial of Intravenous Lipid Emulsion Treatment for Severe Nifedipine-Induced Shock.
Topics: Animals; Blood Glucose; Blood Pressure; Bradycardia; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Fat Emulsions, Intravenous; Female; Heart Arrest, Induced; Humans; Metabolome; Myocardial Contraction; Nifedipine; Pilot Projects; Shock; Swine; Tachycardia | 2016 |
Solid dispersions of efonidipine hydrochloride ethanolate with improved physicochemical and pharmacokinetic properties prepared with microwave treatment.
Topics: Animals; Area Under Curve; Calorimetry, Differential Scanning; Dihydropyridines; Dogs; Drug Carriers; Hot Temperature; Magnetic Resonance Spectroscopy; Male; Methylcellulose; Microwaves; Nitrophenols; Organic Chemicals; Organophosphorus Compounds; Solubility; Solvents; Urea; X-Ray Diffraction | 2016 |
Involvement of dihydropyridine-sensitive calcium channels in high asynchrony of transmitter release in neuromuscular synapses of newborn rats.
Topics: Acetylcholine; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Dose-Response Relationship, Drug; In Vitro Techniques; Ion Channel Gating; Neurogenesis; Neuromuscular Junction; Neurotransmitter Agents; Rats; Rats, Wistar; Synaptic Transmission | 2016 |
Design, synthesis, anticancer, antimicrobial activities and molecular docking studies of novel quinoline bearing dihydropyridines.
Topics: Anti-Infective Agents; Antineoplastic Agents; Dihydropyridines; Drug Design; Molecular Docking Simulation; Quinolines | 2016 |
Design and Synthesis of 1,4-dihydropyridine Derivatives as Anti-cancer Agent.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dihydropyridines; Drug Screening Assays, Antitumor; Humans; Neoplasms; Structure-Activity Relationship | 2017 |
Molecular dynamics simulation and molecular docking studies of 1,4-Dihydropyridines as P-glycoprotein's allosteric inhibitors.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Dihydropyridines; Hydrogen Bonding; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Protein Conformation | 2018 |
Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.
Topics: Amino Acid Sequence; Animals; Benzoxazines; Dihydropyridines; Drug Discovery; Humans; Ligands; Macrolides; Mineralocorticoid Receptor Antagonists; Models, Molecular; Oxazolidinones; Peptides; Pyrazoles; Pyrroles; Receptors, Mineralocorticoid; Structure-Activity Relationship; Sulfonamides | 2017 |
Synthesis and characterization of a novel series of 1,4-dihydropyridine analogues for larvicidal activity against Anopheles arabiensis.
Topics: Animals; Anopheles; Crystallography, X-Ray; Dihydropyridines; Insecticides; Larva; Magnetic Resonance Spectroscopy; Molecular Conformation; Structure-Activity Relationship | 2017 |
Docking and QSAR Studies of 1,4-Dihydropyridine Derivatives as Anti- Cancer Agent.
Topics: Antineoplastic Agents; Dihydropyridines; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Least-Squares Analysis; Linear Models; Models, Molecular; Molecular Docking Simulation; Neoplasms; Quantitative Structure-Activity Relationship | 2017 |
[The Effectiveness of Combination Antihypertensive Therapy in Women With Hypothyroidism and the Metabolic Syndrome].
Topics: Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Dihydropyridines; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Hypothyroidism; Imidazoles; Losartan; Metabolic Syndrome; Middle Aged | 2016 |
Enthalpy-driven interaction between dihydropyrimidine compound and bovine serum albumin: a spectroscopic and computational approach.
Topics: Animals; Binding Sites; Cattle; Dihydropyridines; Models, Molecular; Protein Binding; Serum Albumin, Bovine; Spectrum Analysis | 2018 |
Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Crystallography, X-Ray; Dihydropyridines; Dimerization; Drug Resistance, Multiple; Humans; Isoxazoles; Mice; Molecular Docking Simulation; Protein Binding | 2017 |
Synergy between azoles and 1,4-dihydropyridine derivative as an option to control fungal infections.
Topics: Antifungal Agents; ATP-Binding Cassette Transporters; Candida albicans; Candidiasis; Dihydropyridines; Drug Resistance, Fungal; Drug Synergism; Fluconazole; Fungal Proteins; Gene Expression Regulation, Fungal; Humans; Microbial Sensitivity Tests; Mutation; Sterol 14-Demethylase | 2017 |
Comparison of lercanidipine plus hydrochlorothiazide vs. lercanidipine plus enalapril on micro and macrocirculation in patients with mild essential hypertension.
Topics: Adult; Aged; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Enalapril; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged | 2017 |
Synthesis and in vitro evaluation of Ca
Topics: Animals; Calcium Channel Blockers; Cell Line; Cell Line, Tumor; Dihydropyridines; Humans; Leishmania mexicana; MCF-7 Cells; Mice; NIH 3T3 Cells; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Late-Stage C-H Alkylation of Heterocycles and 1,4-Quinones via Oxidative Homolysis of 1,4-Dihydropyridines.
Topics: Alkylating Agents; Alkylation; Dihydropyridines; Heterocyclic Compounds; Oxidation-Reduction; Quinones | 2017 |
Synthesis and photodegradation studies of analogues of muscle relaxant 1,4-dihydropyridine compounds.
Topics: Animals; Dihydropyridines; In Vitro Techniques; Light; Muscle, Smooth; Neuromuscular Agents; Photolysis; Rabbits; Structure-Activity Relationship | 2017 |
Dihydropyridine-derived BODIPY probe for detecting exogenous and endogenous nitric oxide in mitochondria.
Topics: Animals; Boron Compounds; Cell Survival; Dihydropyridines; Fluorescent Dyes; Hep G2 Cells; Humans; Mice; Mitochondria; Nitric Oxide; Organophosphorus Compounds; RAW 264.7 Cells | 2018 |
Synthesis, Docking Simulation, Biological Evaluations and 3D-QSAR Study of 1,4-Dihydropyridines as Calcium Channel Blockers.
Topics: Animals; Arcobacter; Bacterial Proteins; Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Inhibitory Concentration 50; Molecular Docking Simulation; Protein Structure, Tertiary; Quantitative Structure-Activity Relationship; Rabbits | 2017 |
Taming photo-induced oxidation degradation of dihydropyridine drugs through cocrystallization.
Topics: Calcium Channel Blockers; Crystallization; Dihydropyridines; Molecular Conformation; Niacinamide; Nifedipine; Oxidation-Reduction; Photochemical Processes; Thermodynamics | 2017 |
Benzofuran-dihydropyridine hybrids: A new class of potential bone anabolic agents.
Topics: Administration, Oral; Anabolic Agents; Animals; Benzofurans; Bone Morphogenetic Protein 2; Bone Regeneration; Dihydropyridines; Dose-Response Relationship, Drug; Female; Models, Molecular; Molecular Structure; Osteoblasts; Osteogenesis; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2017 |
Microwave Mediated Synthesis and Analytical Method Development for the Estimation of Novel 1,4-Dihydropyridines in Bulk by RP-HPLC.
Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Dihydropyridines; Microwaves | 2018 |
Selective anticancer activity of the novel steroidal dihydropyridine spirooxindoles against human esophageal EC109 cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Line, Tumor; Dihydropyridines; Drug Resistance; Esophageal Neoplasms; G2 Phase Cell Cycle Checkpoints; Humans; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Small Molecule Libraries | 2017 |
The inhibitor of connexin Cx36 channels, mefloquine, inhibits voltage-dependent Ca
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Connexins; Dihydropyridines; Gap Junction delta-2 Protein; Glucose; Insulin Secretion; Insulin-Secreting Cells; Ion Channel Gating; Mefloquine; Mice; Nisoldipine; Potassium Chloride; Tolbutamide | 2018 |
Anti-cancer activity of a new dihydropyridine derivative, VdiE-2N, in head and neck squamous cell carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dihydropyridines; Gene Expression Regulation, Neoplastic; Genes, myc; Head and Neck Neoplasms; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondrial Size; Neoplasm Invasiveness; Neovascularization, Pathologic; Squamous Cell Carcinoma of Head and Neck; Xenograft Model Antitumor Assays | 2018 |
Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dihydropyridines; Dose-Response Relationship, Drug; Electrophorus; Horses; Molecular Docking Simulation; Molecular Structure; Prodrugs; Pyridinium Compounds; Salts; Structure-Activity Relationship | 2018 |
Screening of illegally adulterated 1,4-dihydropyridine calcium antagonists in traditional Chinese medicines by a high-performance liquid chromatography electrospray ionization in-source collision-induced dissociation triple quadrupole mass spectrometric m
Topics: Calcium; Chromatography, High Pressure Liquid; Dihydropyridines; Drug Contamination; Drugs, Chinese Herbal; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2018 |
Synthesis and DFT Study on Hantzsch Reaction to Produce Asymmetrical Compounds of 1,4-Dihydropyridine Derivatives for P-Glycoprotein Inhibition as Anticancer Agent.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Chemistry, Pharmaceutical; Dihydropyridines; Humans; Stereoisomerism | 2018 |
Discovery of Novel Enhancers of Isoniazid Toxicity in
Topics: Antitubercular Agents; Bacterial Proteins; Dihydropyridines; Isoniazid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Structure-Activity Relationship | 2018 |
The uricosuric effects of dihydropyridine calcium channel blockers in vivo using urate under-excretion animal models.
Topics: Animals; Calcium Channel Blockers; Creatinine; Dihydropyridines; DNA-Binding Proteins; Male; Mice, Inbred ICR; Models, Animal; Organic Anion Transporters; Uric Acid; Uricosuric Agents | 2018 |
Magnetic guanidinylated chitosan nanobiocomposite: A green catalyst for the synthesis of 1,4-dihydropyridines.
Topics: Catalysis; Chitosan; Dihydropyridines; Magnetics; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanocomposites; Solvents; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; X-Ray Diffraction | 2018 |
Binding mechanism investigations guiding the synthesis of novel condensed 1,4-dihydropyridine derivatives with L-/T-type calcium channel blocking activity.
Topics: Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Dose-Response Relationship, Drug; Humans; Molecular Structure; Structure-Activity Relationship | 2018 |
Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Dihydropyridines; Drug Evaluation, Preclinical; Fungi; Humans; Immunologic Factors; Magnetite Nanoparticles; Microbial Sensitivity Tests | 2018 |
Regioselective four-component synthesis of new tetrazolo[1,5-a]quinoline-based 2-amino-1,4-dihydropyridine and pyridin-2(1H)-one derivatives using nano-ZnO catalysis.
Topics: Catalysis; Chemistry Techniques, Synthetic; Dihydropyridines; Nanostructures; Pyridones; Quinolines; Stereoisomerism; Tetrazoles; Zinc Oxide | 2018 |
Access to Highly Enantioenriched Donepezil-like 1,4-Dihydropyridines as Promising Anti-Alzheimer Prodrug Candidates via Enantioselective Tsuji Allylation and Organocatalytic Aza-Ene-Type Domino Reactions.
Topics: Alzheimer Disease; Catalysis; Cyclization; Dihydropyridines; Donepezil; Prodrugs; Stereoisomerism | 2018 |
Structural basis for the hepatoprotective effects of antihypertensive 1,4-dihydropyridine drugs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antihypertensive Agents; Calcium Channel Blockers; Chemical and Drug Induced Liver Injury; Dihydropyridines; HEK293 Cells; Humans; Liver; Male; Mice; Mice, Knockout; Models, Molecular; Protein Conformation; RNA-Binding Proteins | 2018 |
Novel 1,4-dihydropyridine induces apoptosis in human cancer cells through overexpression of Sirtuin1.
Topics: A549 Cells; Apoptosis; Dihydropyridines; Gene Expression Regulation, Neoplastic; HeLa Cells; Hep G2 Cells; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms; Oncogene Protein v-akt; Sirtuin 1; Survivin | 2018 |
Molecular Studies on Novel Antitumor Bis 1,4-Dihydropyridine Derivatives Against Lung Carcinoma and their Limited Side Effects on Normal Melanocytes.
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Carbon-13 Magnetic Resonance Spectroscopy; Cell Cycle Checkpoints; Cell Proliferation; Dihydropyridines; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; MCF-7 Cells; Melanocytes; Molecular Docking Simulation; Proton Magnetic Resonance Spectroscopy | 2018 |
First Organocatalytic Asymmetric Synthesis of 1-Benzamido-1,4-Dihydropyridine Derivatives.
Topics: Calcium Channel Blockers; Catalysis; Dihydropyridines; Heterocyclic Compounds; Hydrazones; Hydroxyquinolines; Molecular Structure; Quinuclidines; Stereoisomerism | 2018 |
Benzimidazoles as Metal-Free and Recyclable Hydrides for CO
Topics: Benzimidazoles; Carbon Dioxide; Dihydropyridines; Electrochemistry; Formates; Models, Molecular; Molecular Conformation; Salts; Solvents | 2019 |
Cardiovascular Profile of Xanthone-Based 1,4 Dihydropyridines Bearing a Lidoflazine Pharmacophore Fragment.
Topics: Animals; Calcium Channels, L-Type; Dihydropyridines; Female; Guinea Pigs; Lidoflazine; Male; Myocardial Contraction; Myocardium; Xanthones | 2018 |
The impact of dihydropyridine derivatives on the cerebral blood flow response to somatosensory stimulation and spreading depolarization.
Topics: Animals; Calcium Channel Blockers; Cerebrovascular Circulation; Dihydropyridines; Male; Rats; Rats, Sprague-Dawley; Somatosensory Cortex | 2019 |
Toward Second-Generation Cardiomyogenic and Anti-cardiofibrotic 1,4-Dihydropyridine-Class TGFβ Inhibitors.
Topics: Animals; Cell Differentiation; Dihydropyridines; Drug Design; Humans; Induced Pluripotent Stem Cells; Myocardial Infarction; Myocytes, Cardiac; Rats; Receptors, Transforming Growth Factor beta; Smad Proteins; Solubility; Structure-Activity Relationship; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta | 2019 |
Urapidil, but not dihydropyridine calcium channel inhibitors, preserves the hypoxic pulmonary vasoconstriction: an experimental study in pig arteries.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Dihydropyridines; Endothelium, Vascular; Hypoxia; Lung; Piperazines; Pulmonary Artery; Swine; Vasoconstriction | 2019 |
Amine-functionalized graphene oxide nanosheets (AFGONs): an efficient bifunctional catalyst for selective formation of 1,4-dihydropyridines, acridinediones and polyhydroquinolines.
Topics: Amines; Catalysis; Chemistry Techniques, Synthetic; Dihydropyridines; Graphite; Hydroquinones; Molecular Structure; Nanostructures; Quinolines; Spectrum Analysis | 2020 |
Direct Enantiomeric Resolution of Seventeen Racemic 1,4-Dihydropyridine-Based Hexahydroquinoline Derivatives by HPLC.
Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Dihydropyridines; Quinolines; Stereoisomerism; Thermodynamics | 2019 |
Regioselective Single-Electron Tsuji-Trost Reaction of Allylic Alcohols: A Photoredox/Nickel Dual Catalytic Approach.
Topics: Catalysis; Diethyl Pyrocarbonate; Dihydropyridines; Electrons; Kinetics; Nickel; Oxidation-Reduction; Phenanthrolines; Photochemistry; Propanols; Stereoisomerism | 2019 |
Dually Acting Nonclassical 1,4-Dihydropyridines Promote the Anti-Tuberculosis (Tb) Activities of Clofazimine.
Topics: Antitubercular Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clofazimine; Dihydropyridines; Drug Synergism; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Spectrum Analysis | 2019 |
Synthesis, in silico and in vitro studies of new 1,4-dihydropiridine derivatives for antitumor and P-glycoprotein inhibitory activity.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Cell Proliferation; Computer Simulation; Dihydropyridines; Doxorubicin; Drug Resistance, Neoplasm; Humans; In Vitro Techniques; Stomach Neoplasms; Tumor Cells, Cultured | 2019 |
Discovery of Michael acceptor containing 1,4-dihydropyridines as first covalent inhibitors of L-/T-type calcium channels.
Topics: Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cysteine; Dihydropyridines; Drug Discovery; Glutathione; Humans; Models, Molecular; Protein Conformation | 2019 |
Multi-target 1,4-dihydropyridines showing calcium channel blockade and antioxidant capacity for Alzheimer's disease therapy.
Topics: Alzheimer Disease; Antioxidants; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Humans; Melatonin; Neuroblastoma; Nimodipine; Tumor Cells, Cultured | 2019 |
Synthesis, Cytotoxicity and Molecular Docking Simulation of Novel bis-1,4-Dihydropyridines Linked to Aliphatic or Arene Core via Amide or Ester-Amide Linkages.
Topics: Amides; Antineoplastic Agents; Binding Sites; Catalytic Domain; Cell Line, Tumor; Cell Survival; Dihydropyridines; Esters; Humans; Inhibitor of Apoptosis Proteins; Molecular Docking Simulation; Structure-Activity Relationship | 2020 |
Synthesis, Biological Evaluation and Molecular Docking Studies of Novel Di-hydropyridine Analogs as Potent Antioxidants.
Topics: Animals; Antioxidants; Chelating Agents; Computer Simulation; Dihydropyridines; Hemolysis; Molecular Docking Simulation; Structure-Activity Relationship | 2019 |
1,4-Dihydropyridine (DHP) suppresses against oxidative stress in nucleus pulposus via activating sirtuin-1.
Topics: Adult; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Humans; Male; Nucleus Pulposus; Oxidative Stress; Sirtuin 1 | 2020 |
Development of an efficient biocatalytic system based on bacterial laccase for the oxidation of selected 1,4-dihydropyridines.
Topics: Bacillus; Biocatalysis; Dihydropyridines; Enzymes, Immobilized; Hydrogen-Ion Concentration; Laccase; Oxidation-Reduction; Temperature | 2020 |
Preparation of a novel magnetic bionanocomposite based on factionalized chitosan by creatine and its application in the synthesis of polyhydroquinoline, 1,4-dyhdropyridine and 1,8-dioxo-decahydroacridine derivatives.
Topics: Acridines; Catalysis; Chitosan; Creatine; Dihydropyridines; Magnetite Nanoparticles; Magnetometry; Nanocomposites; Quinolines; Spectrometry, X-Ray Emission; Spectroscopy, Fourier Transform Infrared; Temperature; Thermogravimetry; Vibration; X-Ray Diffraction | 2020 |
Magnitude of and Characteristics Associated With the Treatment of Calcium Channel Blocker-Induced Lower-Extremity Edema With Loop Diuretics.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Cohort Studies; Dihydropyridines; Drug Therapy, Combination; Edema; Female; Humans; Hypertension; Leg; Male; Middle Aged; Young Adult | 2019 |
Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of
Topics: Actin Cytoskeleton; Animals; Anti-Infective Agents; Bacterial Toxins; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Clostridioides difficile; Cytokines; Dihydropyridines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glucosyltransferases; Humans; Kinetics; Mice; NADPH Oxidases; Necrosis; Reactive Oxygen Species; Virulence Factors | 2020 |
Anticancer activity of a 1,4-dihydropyridine in DMBA-induced mouse skin tumor model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Calcium Channel Blockers; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Dihydropyridines; Male; Mice; Organ Size; Skin Neoplasms; Tumor Cells, Cultured | 2020 |
Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels.
Topics: Alzheimer Disease; Antioxidants; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line, Tumor; Dihydropyridines; Humans; Ligands; Monoamine Oxidase Inhibitors; Neuroprotection; Neuroprotective Agents; Nimodipine | 2020 |
4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action.
Topics: Animals; Calcium; Dihydropyridines; Humans; Ion Transport; Rats; Tumor Cells, Cultured | 2020 |
Theoretical studies on 1,4-dihydropyridine derivatives as P-glycoprotein allosteric inhibitors: insights on symmetry and stereochemistry.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Molecular Docking Simulation | 2021 |
Dihydropyridine-coumarin-based fluorescent probe for imaging nitric oxide in living cells.
Topics: Animals; Cell Survival; Cells, Cultured; Coumarins; Dihydropyridines; Dose-Response Relationship, Drug; Fluorescent Dyes; Mice; Molecular Structure; Nitric Oxide; Optical Imaging; RAW 264.7 Cells | 2020 |
Novel ureido-dihydropyridine scaffolds as theranostic agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dihydropyridines; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Structure-Activity Relationship; Urea | 2020 |
Dual active 1, 4-dihydropyridine derivatives: Design, green synthesis and in vitro anti-cancer and anti-oxidant studies.
Topics: Antineoplastic Agents; Antioxidants; Biphenyl Compounds; Cell Proliferation; Dihydropyridines; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Picrates; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Ca
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amlodipine; Binding Sites; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cryoelectron Microscopy; Dihydropyridines; Molecular Dynamics Simulation; Nanostructures; Protein Structure, Tertiary; Stereoisomerism | 2021 |
Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate.
Topics: Animals; Armadillo Domain Proteins; Cryoelectron Microscopy; Cytoskeletal Proteins; Dihydropyridines; Drug Evaluation, Preclinical; Fluorescent Dyes; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Neurons; Neuroprotection; Pharmaceutical Preparations | 2021 |
Lacidipine: review of analytical methods developed for pharmaceutical dosage forms and biological fluids.
Topics: Calcium Channel Blockers; Dihydropyridines; Pharmaceutical Preparations; Spectrophotometry, Ultraviolet | 2021 |
Revisiting ageless antiques; synthesis, biological evaluation, docking simulation and mechanistic insights of 1,4-Dihydropyridines as anticancer agents.
Topics: Antineoplastic Agents; Cell Line; Cell Proliferation; Dihydropyridines; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship | 2021 |
1,4-dihydropyridine derivatives increase mRNA expression of
Topics: Animals; Dihydropyridines; Kidney; Proteasome Endopeptidase Complex; Rats; RNA, Messenger | 2021 |
One-component nano-metal-organic frameworks with superior multienzyme-mimic activities for 1,4-dihydropyridine metabolism.
Topics: Catalysis; Dihydropyridines; Hydrogen Peroxide; Metal-Organic Frameworks | 2022 |
A novel mitochondrial-targeting fluorescent probe based on 1,4-dihydropyridine to visualize and monitor the viscosity of live cells and mice
Topics: Animals; Dihydropyridines; Fluorescent Dyes; HeLa Cells; Humans; Mice; Mitochondria; Viscosity | 2021 |
A novel fluorescent probe with aggregation induced emission (AIE) effect based on 1,4-dihydropyridine and its applications.
Topics: Dihydropyridines; Fluorescent Dyes; HeLa Cells; Humans; Spectrometry, Fluorescence | 2022 |
Synthesis, spectroscopic, DFT, and molecular docking studies on 1,4-dihydropyridine derivative compounds: a combined experimental and theoretical study.
Topics: Calcium Channel Blockers; Chemistry Techniques, Synthetic; Density Functional Theory; Dihydropyridines; Ligands; Molecular Docking Simulation; Molecular Structure; Spectrum Analysis; Structure-Activity Relationship | 2021 |
Selective Spectrofluorimetric Protocol for Determination of Commonly Used Gram-negative Bactericidal Drug in Combined Pharmaceutical Dosage Forms and Human Plasma.
Topics: Anti-Bacterial Agents; Buffers; Dihydropyridines; Dosage Forms; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Molecular Structure; Polymyxin B; Spectrometry, Fluorescence; Temperature | 2022 |
Selective Synthesis of the Aminobutadiene Intermediate and Mechanistic Analysis of 1,4-Dihydropyridine Formation Reaction in Water.
Topics: Amines; Cyclization; Dihydropyridines; Water | 2022 |
Comparison between 1,2-Dihydropyridine and 1,4-Dihydropyridine on Hydride-Donating Ability and Activity.
Topics: Dihydropyridines; Kinetics; Thermodynamics | 2022 |
Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis,
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Dihydropyridines; Humans; Molecular Docking Simulation; Nitriles; Structure-Activity Relationship | 2022 |
Novel 1,4-Dihydropyridine Derivatives as Mineralocorticoid Receptor Antagonists.
Topics: Aldosterone; Calcium Channel Blockers; Dihydropyridines; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid | 2023 |
Simple dihydropyridine-based colorimetric chemosensors for heavy metal ion detection, biological evaluation, molecular docking, and ADMET profiling.
Topics: Colorimetry; Dihydropyridines; Ions; Metals, Heavy; Molecular Docking Simulation; Proto-Oncogene Proteins c-akt | 2023 |
Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Asparagine; Calcium; Cryoelectron Microscopy; Dihydropyridines; Isoleucine; Nitrogen Dioxide; Sodium Channels | 2023 |