1,4-dihydro-2,6-dimethyl-4-phenyl-3,5-pyridinecarboxylic acid dimethyl ester has been researched along with nifedipine in 5 studies
| Studies (1,4-dihydro-2,6-dimethyl-4-phenyl-3,5-pyridinecarboxylic acid dimethyl ester) | Trials (1,4-dihydro-2,6-dimethyl-4-phenyl-3,5-pyridinecarboxylic acid dimethyl ester) | Recent Studies (post-2010) (1,4-dihydro-2,6-dimethyl-4-phenyl-3,5-pyridinecarboxylic acid dimethyl ester) | Studies (nifedipine) | Trials (nifedipine) | Recent Studies (post-2010) (nifedipine) |
|---|---|---|---|---|---|
| 10 | 0 | 3 | 16,024 | 2,496 | 1,505 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coburn, RA; Solo, AJ; Suto, MJ; Triggle, AM; Triggle, DJ; Wierzba, M | 1 |
| Böcker, RH; Guengerich, FP | 1 |
| Fossheim, R; Mostad, A; Rømming, C; Shefter, E; Svarteng, K; Triggle, DJ | 1 |
| Schleifer, KJ | 1 |
| Caron, G; Ermondi, G; Galietta, L; Medana, C; Pedemonte, N; Visentin, S | 1 |
5 other study(ies) available for 1,4-dihydro-2,6-dimethyl-4-phenyl-3,5-pyridinecarboxylic acid dimethyl ester and nifedipine
| Article | Year |
|---|---|
1,4-Dihydropyridine antagonist activities at the calcium channel: a quantitative structure-activity relationship approach.
Topics: Animals; Calcium Channels; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Mathematics; Muscle Contraction; Structure-Activity Relationship | 1988 |
Oxidation of 4-aryl- and 4-alkyl-substituted 2,6-dimethyl-3,5-bis(alkoxycarbonyl)-1,4-dihydropyridines by human liver microsomes and immunochemical evidence for the involvement of a form of cytochrome P-450.
Topics: Chemical Phenomena; Chemistry; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Microsomes, Liver; NADP; Nifedipine; Oxidation-Reduction | 1986 |
Crystal structures and pharmacological activity of calcium channel antagonists: 2,6-dimethyl-3,5-dicarbomethoxy-4-(unsubstituted, 2-methyl-, 4-methyl-, 3-nitro-, 4-nitro-, and 2,4-dinitrophenyl)-1,4-dihydropyridine.
Topics: Calcium Channel Blockers; Chemical Phenomena; Chemistry; Dihydropyridines; Models, Molecular; Molecular Conformation; Nifedipine; Phosphorylcholine; Pyridines; Structure-Activity Relationship; X-Ray Diffraction | 1982 |
Stereoselective characterization of the 1,4-dihydropyridine binding site at L-type calcium channels in the resting state and the opened/inactivated state.
Topics: Binding Sites; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Ion Channel Gating; Models, Molecular; Molecular Conformation; Stereoisomerism | 1999 |
Ligand-based design, in silico ADME-Tox filtering, synthesis and biological evaluation to discover new soluble 1,4-DHP-based CFTR activators.
Topics: Absorption; Animals; Calcium Channel Blockers; Chemistry Techniques, Synthetic; Computational Biology; Cystic Fibrosis Transmembrane Conductance Regulator; Dihydropyridines; Drug Design; Humans; Ligands; Models, Molecular; Mutation; Protein Conformation; Quantitative Structure-Activity Relationship; Rats; Solubility | 2012 |