Compounds > 1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester
Page last updated: 2024-09-04

1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester and nitrendipine

1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester has been researched along with nitrendipine in 2 studies

Compound Research Comparison

Studies
(1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester)		Trials
(1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester)		Recent Studies (post-2010)
(1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester)		Studies
(nitrendipine)		Trials
(nitrendipine)		Recent Studies (post-2010) (nitrendipine)
6012,17037883

Protein Interaction Comparison

ProteinTaxonomy1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester (IC50)nitrendipine (IC50)
G-protein coupled receptor 55Homo sapiens (human)1.4652
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.0152
Cytochrome P450 2C9 Homo sapiens (human)0.3
Voltage-dependent L-type calcium channel subunit alpha-1CRattus norvegicus (Norway rat)0.0013
Voltage-dependent L-type calcium channel subunit alpha-1DRattus norvegicus (Norway rat)0.0013
Cytochrome P450 2C19Homo sapiens (human)3
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.0152
Voltage-dependent L-type calcium channel subunit alpha-1SRattus norvegicus (Norway rat)0.0013
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)10
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.0152
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.0152
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)1.85

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cao, S; Chang, CC; Dunne, SF; Kai, L; Kang, S; Luan, CH; Pandey, P; Silverman, RB; Surmeier, DJ; Tian, X1
Caron, G; Ermondi, G; Galietta, L; Medana, C; Pedemonte, N; Visentin, S1

Other Studies

2 other study(ies) available for 1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester and nitrendipine

ArticleYear
Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2.
    Bioorganic & medicinal chemistry, 2010, May-01, Volume: 18, Issue:9

    Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Dicarboxylic Acids; Dihydropyridines; Humans; Inhibitory Concentration 50; Molecular Structure; Nifedipine

2010
Ligand-based design, in silico ADME-Tox filtering, synthesis and biological evaluation to discover new soluble 1,4-DHP-based CFTR activators.
    European journal of medicinal chemistry, 2012, Volume: 55

    Topics: Absorption; Animals; Calcium Channel Blockers; Chemistry Techniques, Synthetic; Computational Biology; Cystic Fibrosis Transmembrane Conductance Regulator; Dihydropyridines; Drug Design; Humans; Ligands; Models, Molecular; Mutation; Protein Conformation; Quantitative Structure-Activity Relationship; Rats; Solubility

2012