Page last updated: 2024-08-18

1,4-butanediol and fomepizole

1,4-butanediol has been researched along with fomepizole in 6 studies

Research

Studies (6)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (66.67)	29.6817
2010's	2 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baud, FJ; Fompeydie, D; Garnier, R; Mégarbane, B	1
Desai, MC; Maher, TJ; Quang, LS; Shannon, MW; Woolf, AD	2
Desai, MC; Kraner, JC; Maher, TJ; Quang, LS; Shannon, MW; Woolf, AD	1
Beike, J; Bender, K; Jübner, M; Käferstein, H; Lenz, D; Rothschild, MA; Wintermeyer, A	1
Benowitz, NL; Dempsey, DA; Gugelmann, H; Havel, C; Jacob, P; Liakoni, E; Wiegand, TJ	1

Trials

1 trial(s) available for 1,4-butanediol and fomepizole

Article	Year
Butanediol Conversion to Gamma-Hydroxybutyrate Markedly Reduced by the Alcohol Dehydrogenase Blocker Fomepizole. Clinical pharmacology and therapeutics, 2019, Volume: 105, Issue:5 Topics: Adult; Alcohol Dehydrogenase; Butylene Glycols; Cross-Over Studies; Double-Blind Method; Drug Monitoring; Enzyme Inhibitors; Fomepizole; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Psychotropic Drugs; Sodium Oxybate; Solvents; Treatment Outcome	2019

Article

Year

Butanediol Conversion to Gamma-Hydroxybutyrate Markedly Reduced by the Alcohol Dehydrogenase Blocker Fomepizole.

Clinical pharmacology and therapeutics, 2019, Volume: 105, Issue:5

Topics: Adult; Alcohol Dehydrogenase; Butylene Glycols; Cross-Over Studies; Double-Blind Method; Drug Monitoring; Enzyme Inhibitors; Fomepizole; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Psychotropic Drugs; Sodium Oxybate; Solvents; Treatment Outcome

2019

Other Studies

5 other study(ies) available for 1,4-butanediol and fomepizole

Article	Year
Treatment of a 1,4-butanediol poisoning with fomepizole. Journal of toxicology. Clinical toxicology, 2002, Volume: 40, Issue:1 Topics: Adult; Antidotes; Butylene Glycols; Coma; Fomepizole; Humans; Hydroxybutyrates; Infusions, Intravenous; Male; Pyrazoles; Seizures; Solvents; Substance-Related Disorders; Treatment Outcome	2002
Pretreatment of CD-1 mice with 4-methylpyrazole blocks toxicity from the gamma-hydroxybutyrate precursor, 1,4-butanediol. Life sciences, 2002, Jul-05, Volume: 71, Issue:7 Topics: Alcohol Dehydrogenase; Animals; Antidotes; Biotransformation; Butylene Glycols; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fomepizole; Male; Mice; Postural Balance; Pyrazoles; Sodium Oxybate	2002
Enzyme and receptor antagonists for preventing toxicity from the gamma-hydroxybutyric acid precursor 1,4-butanediol in CD-1 mice. Annals of the New York Academy of Sciences, 2002, Volume: 965 Topics: Animals; Antidotes; Biotransformation; Butylene Glycols; Enzyme Inhibitors; Fomepizole; gamma-Aminobutyric Acid; Male; Mice; Posture; Pyrazoles; Reflex	2002
4-methylpyrazole decreases 1,4-butanediol toxicity by blocking its in vivo biotransformation to gamma-hydroxybutyric acid. Annals of the New York Academy of Sciences, 2004, Volume: 1025 Topics: Animals; Biotransformation; Butylene Glycols; Fomepizole; Hydroxybutyrates; Male; Mice; Motor Skills; Pyrazoles; Rotarod Performance Test	2004
Inhibition of 1,4-butanediol metabolism in human liver in vitro. Naunyn-Schmiedeberg's archives of pharmacology, 2011, Volume: 383, Issue:6 Topics: Adult; Aged; Antidotes; Butylene Glycols; Cimetidine; Disulfiram; Drug Interactions; Ethanol; Female; Fomepizole; Gas Chromatography-Mass Spectrometry; Humans; Hydroxybutyrates; In Vitro Techniques; Liver; Male; Middle Aged; Pyrazoles	2011