1,4-butanediol has been researched along with 4-butyrolactone in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.44) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 24 (58.54) | 29.6817 |
| 2010's | 15 (36.59) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Bourguignon, JJ; Charlier, B; Hechler, V; Maitre, M; Schmitt, M; Schoenfelder, A; Wermuth, CG | 1 |
| Quang, LS; Shannon, M | 1 |
| Jain, AL; Swadron, SP | 1 |
| Byers, KL; Duer, WC; Martin, JV | 1 |
| Dahlén, J; Vriesman, T | 1 |
| Carter, LP; Chen, W; Coop, A; Flores, LR; France, CP; Unzeitig, AW; Wu, H | 1 |
| Coop, A; France, CP; McMahon, LR; Winger, G; Woolverton, WL | 1 |
| Baker, LE; Poling, A; Pynnonen, D | 1 |
| Coleman, SL; de Fiebre, CM; de Fiebre, NE; Forster, MJ | 1 |
| Palmer, RB | 1 |
| Morris-Kukoski, CL | 1 |
| Authier, N; Coudoré, F; Eschalier, A; Faict, TW; Ling, B; Richard, D | 1 |
| Carter, LP; Chen, W; Coop, A; France, CP; Koek, W; Lamb, RJ; Wu, H | 1 |
| Gibson, KM; Snead, OC | 1 |
| Carter, LP; Coop, A; France, CP; Koek, W; Wu, H | 1 |
| Carter, LP; France, CP; Koek, W | 1 |
| Boje, KM; Fung, HL; Paganelli, M; Page, NA | 1 |
| Ariniemi, K; Kankaanpää, A; Liukkonen, R | 1 |
| Maytum, HC; Tavassoli, B; Williams, JM | 1 |
| Ashraf, T; Clarke, S; Dargan, PI; Greene, SL; Holt, DW; Ramsey, J; Shather, Z; Trivedy, C; Warren-Gash, C; Wood, DM | 1 |
| Wax, PM; Wojtowicz, JM; Yarema, MC | 1 |
| Greter, J; Knudsen, K; Verdicchio, M | 1 |
| Baker, LE; Poling, A; Pynnonen, DM; Searcy, GD | 1 |
| Brown, PR; Gibson, KM; Goodwin, AK; Jakobs, C; Jansen, EE; Weerts, EM | 1 |
| Duketis, E; Holtmann, M; Maier, J; Poustka, F; Radeloff, D; Schirman, S; Wagner, A; Wöckel, L; Zepf, FD | 1 |
| Kerrigan, S; Simons, KD; Stout, PA | 1 |
| Dahl, SR; Olsen, KM; Strand, DH | 1 |
| Dematteis, M; Mallaret, M; Pennel, L | 1 |
| Knudsen, K; Mégarbane, B; Schep, LJ; Slaughter, RJ; Vale, JA | 1 |
| Hasselstrøm, JB; Sørensen, LK | 1 |
| Goodwin, AK; Kaminski, BJ; Weerts, EM | 1 |
| Maher, TJ; Phattanarudee, S; Towiwat, P | 1 |
| Bartolucci, G; Frediani, P; Rosi, L | 1 |
| Brunt, TM; van Amsterdam, JG; van den Brink, W | 1 |
| Cho, KH; Choi, SJ; Hong, KK; Kim, JH; Kim, JN; Lee, JC; Lee, JH; Park, HM; Shin, HK; Song, GH; Yang, YL; Yoon, JH | 1 |
| Claridge, H; Corazza, O; Corkery, JM; Elliott, S; Goodair, C; Loi, B; Schifano, F | 1 |
| Cui, XP; Shen, BH; Shi, Y; Xiang, P | 1 |
| Bosch, OG; Seifritz, E | 1 |
| Calero, P; Lennen, RM; Long, KS; Nielsen, AT; Rau, MH | 1 |
| Castro, AL; Dias, AS; Franco, JM; Melo, P; Tarelho, S; Teixeira, HM | 1 |
| Bargel, S; Bonnet, A; Boukerma, AK; Chevallier, C; Dufayet, L; Evrard, M; Guillotin, S; Loeuillet, E; Paradis, C; Pouget, AM; Reynoard, J; Vaucel, JA | 1 |
12 review(s) available for 1,4-butanediol and 4-butyrolactone
| Article | Year |
|---|---|
Gamma-hydroxybutyrate, gamma-butyrolactone, and 1,4-butanediol: a case report and review of the literature.
Topics: 4-Butyrolactone; Adjuvants, Anesthesia; Adolescent; Butylene Glycols; Emergency Medical Services; Female; Humans; Lorazepam; Seizures; Sodium Oxybate; Structure-Activity Relationship; Substance-Related Disorders; Treatment Outcome | 2000 |
Gamma-butyrolactone and 1,4-butanediol: abused analogues of gamma-hydroxybutyrate.
Topics: 4-Butyrolactone; Body Temperature Regulation; Butylene Glycols; GABA Modulators; Humans; Illicit Drugs; Seizures; Sodium Oxybate; Substance Withdrawal Syndrome; Substance-Related Disorders | 2004 |
Gamma-hydroxybutyrate: bridging the clinical-analytical gap.
Topics: 4-Butyrolactone; Butylene Glycols; Chemical Phenomena; Chemistry, Physical; Chromatography, Gas; GABA Modulators; Gas Chromatography-Mass Spectrometry; Humans; Illicit Drugs; Sodium Oxybate; Substance Abuse Detection | 2004 |
Gamma-hydroxybutyric acid.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Humans; Hydroxybutyrates; Receptors, Cell Surface; Receptors, Dopamine; Receptors, GABA; Substance Withdrawal Syndrome; Substance-Related Disorders | 2005 |
Withdrawal from gamma-hydroxybutyrate, 1,4-butanediol and gamma-butyrolactone: a case report and systematic review.
Topics: 4-Butyrolactone; Adult; Butylene Glycols; Humans; Illicit Drugs; Male; Rhabdomyolysis; Seizures; Sodium Oxybate; Substance Withdrawal Syndrome | 2008 |
[Withdrawal syndrome after abuse of GHB (Gamma-Hydroxybutyrate) and its physiological precursors - its relevance for child and adolescent psychiatrists].
Topics: 4-Butyrolactone; Acute Disease; Adolescent; Anesthetics, Intravenous; Antipsychotic Agents; Benzodiazepines; Butylene Glycols; Child; Critical Care; Delusions; Diagnosis, Differential; Drug Interactions; Humans; Psychoses, Substance-Induced; Sodium Oxybate; Substance Withdrawal Syndrome; Substance-Related Disorders | 2009 |
[Current knowledge on gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL) and 1 ,4-butanediol (1,4-BD)].
Topics: 4-Butyrolactone; Butylene Glycols; Humans; Hydroxybutyrates; Illicit Drugs; Knowledge; Models, Biological; Substance-Related Disorders | 2012 |
The clinical toxicology of γ-hydroxybutyrate, γ-butyrolactone and 1,4-butanediol.
Topics: 4-Butyrolactone; Antidotes; Butylene Glycols; Charcoal; Humans; Sodium Oxybate; Substance Withdrawal Syndrome; Therapeutic Irrigation; Tissue Distribution | 2012 |
GHB, GBL and 1,4-BD addiction.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Humans; Hydroxybutyrates; Substance-Related Disorders | 2014 |
Gamma hydroxybutyrate (GHB), gamma butyrolactone (GBL) and 1,4-butanediol (1,4-BD; BDO): A literature review with a focus on UK fatalities related to non-medical use.
Topics: 4-Butyrolactone; Butylene Glycols; Female; Humans; Male; Sodium Oxybate; Substance-Related Disorders; United Kingdom | 2015 |
The behavioural profile of gamma-hydroxybutyrate, gamma-butyrolactone and 1,4-butanediol in humans.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Central Nervous System Depressants; Circadian Rhythm; Eating; Humans; Sexual Behavior; Social Behavior; Sodium Oxybate; Substance Withdrawal Syndrome | 2016 |
Gamma-hydroxybutyrate (GHB), 1,4-butanediol (1,4BD), and gamma-butyrolactone (GBL) intoxication: A state-of-the-art review.
Topics: 4-Butyrolactone; gamma-Aminobutyric Acid; Humans; Sodium Oxybate; Substance Withdrawal Syndrome | 2023 |
29 other study(ies) available for 1,4-butanediol and 4-butyrolactone
| Article | Year |
|---|---|
Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies.
Topics: Animals; Binding Sites; Brain; Hydroxybutyrates; In Vitro Techniques; Rats; Structure-Activity Relationship | 1988 |
Gamma-hydroxybutyrate, gamma-butyrolactone, and 1,4-butanediol.
Topics: 4-Butyrolactone; Acid-Base Equilibrium; Bromides; Butylene Glycols; Coma; Humans; Prodrugs; Seizures | 2001 |
Application of a convenient extraction procedure to analyze gamma-hydroxybutyric acid in fatalities involving gamma-hydroxybutyric acid, gamma-butyrolactone, and 1,4-butanediol.
Topics: 4-Butyrolactone; Autopsy; Butylene Glycols; Chemistry Techniques, Analytical; Humans; Hydroxybutyrates; Poisoning; Solvents; Tissue Distribution | 2001 |
Simultaneous analysis of gamma-hydroxybutyric acid, gamma-butyrolactone, and 1,4-butanediol by micellar electrokinetic chromatography.
Topics: 4-Butyrolactone; Butylene Glycols; Chromatography, Micellar Electrokinetic Capillary; Hydroxybutyrates; Solvents | 2002 |
The role of GABAB receptors in the discriminative stimulus effects of gamma-hydroxybutyrate in rats: time course and antagonism studies.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Food; GABA Agonists; GABA Modulators; GABA-B Receptor Antagonists; Kinetics; Male; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology; Sodium Oxybate | 2003 |
Evaluation of the reinforcing and discriminative stimulus effects of 1,4-butanediol and gamma-butyrolactone in rhesus monkeys.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Discrimination Learning; Flumazenil; GABA Modulators; Injections, Intravenous; Macaca mulatta; Male; Midazolam; Pentobarbital; Receptors, GABA-A; Reinforcement, Psychology; Self Administration | 2003 |
Influence of reinforcer type and route of administration on gamma-hydroxybutyrate discrimination in rats.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Central Nervous System Depressants; Conditioning, Operant; Discrimination Learning; Ethanol; Food; Injections, Intraperitoneal; Intubation, Gastrointestinal; Male; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Sodium Oxybate; Solvents; Water | 2004 |
Comparison of the actions of gamma-butyrolactone and 1,4-butanediol in Swiss-Webster mice.
Topics: 4-Butyrolactone; Animals; Body Temperature; Butylene Glycols; Male; Mice; Motor Activity | 2004 |
GC/MS profiling of gamma-hydroxybutyrate and precursors in various animal tissues using automatic solid-phase extraction. Preliminary investigations of its potential interest in postmortem interval determination.
Topics: 4-Butyrolactone; Animal Structures; Animals; Butylene Glycols; Calibration; Central Nervous System; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Male; Postmortem Changes; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Sodium Oxybate; Solid Phase Extraction; Temperature; Time Factors | 2005 |
Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) in rats discriminating GHB from baclofen and diazepam.
Topics: 4-Butyrolactone; Anesthetics, Intravenous; Animals; Baclofen; Benzocycloheptenes; Benzylamines; Butylene Glycols; Diazepam; Discrimination, Psychological; Dithiothreitol; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Male; Organophosphorus Compounds; Phosphinic Acids; Rats; Rats, Sprague-Dawley; Sodium Oxybate | 2005 |
Discriminative stimulus effects of flumazenil: perceptual masking by baclofen, and lack of substitution with gamma-hydroxybutyrate and its precursors 1,4-butanediol and gamma-butyrolactone.
Topics: 4-Butyrolactone; Animals; Baclofen; Benzocycloheptenes; Butylene Glycols; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Organophosphorus Compounds; Sodium Oxybate | 2006 |
Lack of effects of GHB precursors GBL and 1,4-BD following i.c.v. administration in rats.
Topics: 4-Butyrolactone; Anesthetics, Intravenous; Animals; Baclofen; Behavior, Animal; Blood-Brain Barrier; Brain; Butylene Glycols; GABA Agonists; Injections, Intraperitoneal; Injections, Intraventricular; Male; Rats; Rats, Sprague-Dawley; Sodium Oxybate | 2006 |
An interactive lesson in acid/base and pro-drug chemistry using sodium gamma-hydroxybutyrate and commercial test coasters.
Topics: 4-Butyrolactone; Acid-Base Equilibrium; Adolescent; Adult; Anesthetics, Intravenous; Beverages; Butylene Glycols; Education, Pharmacy; Female; Humans; Male; Prodrugs; Reagent Strips; Sodium Oxybate | 2007 |
Determination of gamma-hydroxybutyrate (GHB) and its precursors in blood and urine samples: a salting-out approach.
Topics: 4-Butyrolactone; Analytic Sample Preparation Methods; Butylene Glycols; Central Nervous System Depressants; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Sodium Chloride; Sodium Oxybate; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection | 2007 |
Reduction of aldehydes and ketones by transfer hydrogenation with 1,4-butanediol.
Topics: 4-Butyrolactone; Aldehydes; Butylene Glycols; Combinatorial Chemistry Techniques; Ketones; Molecular Structure; Oxidation-Reduction | 2007 |
Medical and legal confusion surrounding gamma-hydroxybutyrate (GHB) and its precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4BD).
Topics: 4-Butyrolactone; Adult; Aged; Butylene Glycols; Emergency Medical Services; Female; Humans; Illicit Drugs; Length of Stay; Male; Middle Aged; Retrospective Studies; Sodium Oxybate; Substance-Related Disorders | 2008 |
High mortality rates among GHB abusers in Western Sweden.
Topics: 4-Butyrolactone; Adolescent; Adult; Anesthetics, Intravenous; Butylene Glycols; Cause of Death; Female; Forensic Medicine; Humans; Illicit Drugs; Male; Police; Sodium Oxybate; Substance Abuse Detection; Substance-Related Disorders; Sweden | 2008 |
Differentiating the discriminative stimulus effects of gamma-hydroxybutyrate and ethanol in a three-choice drug discrimination procedure in rats.
Topics: 4-Butyrolactone; Animals; Baclofen; Benzocycloheptenes; Butylene Glycols; Discrimination, Psychological; Ethanol; Flunitrazepam; GABA Agonists; GABA Antagonists; GABA Modulators; Ketamine; Male; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Sodium Oxybate | 2008 |
Behavioral effects and pharmacokinetics of gamma-hydroxybutyrate (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons.
Topics: 4-Butyrolactone; Animals; Area Under Curve; Behavior, Animal; Butylene Glycols; Conditioning, Operant; Dose-Response Relationship, Drug; Food; GABA Modulators; Male; Motor Skills; Papio; Prodrugs; Reward; Sodium Oxybate; Substance-Related Disorders | 2009 |
Quantitative analysis of gamma-hydroxybutyrate at endogenous concentrations in hair using liquid chromatography tandem mass spectrometry.
Topics: 3-Hydroxybutyric Acid; 4-Butyrolactone; Butylene Glycols; Chromatography, Liquid; Forensic Toxicology; Hair; Humans; Sodium Oxybate; Tandem Mass Spectrometry | 2010 |
Determination of γ-hydroxybutyrate (GHB), β-hydroxybutyrate (BHB), pregabalin, 1,4-butane-diol (1,4BD) and γ-butyrolactone (GBL) in whole blood and urine samples by UPLC-MSMS.
Topics: 3-Hydroxybutyric Acid; 4-Butyrolactone; Butylene Glycols; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Humans; Illicit Drugs; Pregabalin; Reproducibility of Results; Sensitivity and Specificity; Sodium Oxybate; Tandem Mass Spectrometry | 2012 |
A hydrophilic interaction liquid chromatography electrospray tandem mass spectrometry method for the simultaneous determination of γ-hydroxybutyrate and its precursors in forensic whole blood.
Topics: 4-Butyrolactone; Butylene Glycols; Central Nervous System Depressants; Chromatography, Liquid; Citrates; Drug Stability; Fixatives; Forensic Toxicology; Humans; Limit of Detection; Oxalates; Reproducibility of Results; Sodium Fluoride; Sodium Oxybate; Solid Phase Extraction; Specimen Handling; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2012 |
Self-administration of gamma-hydroxybutyric acid (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Cocaine; Dose-Response Relationship, Drug; Hydroxybutyrates; Injections, Intravenous; Male; Papio; Prodrugs; Reinforcement Schedule; Reinforcement, Psychology; Self Administration | 2013 |
Comparative study of equimolar doses of gamma-hydroxybutyrate (GHB), 1,4-butanediol (1,4-BD) and gamma-butyrolactone (GBL) on catalepsy after acute and chronic administration.
Topics: 4-Butyrolactone; Animals; Area Under Curve; Butylene Glycols; Catalepsy; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Sodium Oxybate; Toxicity Tests, Acute; Toxicity Tests, Chronic | 2013 |
Determination of GHB and its precursors (GBL and 1,4-BD) in dietary supplements through the synthesis of their isotopologues and analysis by GC-MS method.
Topics: 4-Butyrolactone; Butylene Glycols; Dietary Supplements; Gas Chromatography-Mass Spectrometry; Hydroxybutyrates; Prodrugs; Reproducibility of Results | 2013 |
O-Succinyl-L-homoserine-based C4-chemical production: succinic acid, homoserine lactone, γ-butyrolactone, γ-butyrolactone derivatives, and 1,4-butanediol.
Topics: 4-Butyrolactone; Bioreactors; Butylene Glycols; Escherichia coli; Fermentation; Homoserine; Hydrolysis; Solubility; Succinic Acid | 2014 |
[Analysis of GHB and Its Precursors in Urine and Their Forensic Application].
Topics: 4-Butyrolactone; Butylene Glycols; Chromatography, Liquid; Forensic Sciences; Humans; Hydroxybutyrates; Mass Spectrometry; Reproducibility of Results; Tandem Mass Spectrometry | 2015 |
Genome-wide Escherichia coli stress response and improved tolerance towards industrially relevant chemicals.
Topics: 4-Butyrolactone; Biofuels; Butanols; Butylene Glycols; Drug Tolerance; Escherichia coli; Escherichia coli Proteins; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genome, Bacterial; Mutation; Organic Chemicals; Regulon; Solvents; Stress, Physiological; Succinates; Systems Biology | 2016 |
Quantification of GHB and GHB-GLUC in an 1,4-butanediol intoxication: A case report.
Topics: 4-Butyrolactone; Adult; Butylene Glycols; Gas Chromatography-Mass Spectrometry; Humans; Hydroxybutyrates; Male | 2019 |