1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone and lovastatin

1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone has been researched along with lovastatin in 2 studies

Compound Research Comparison

Studies (1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone)	Trials (1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone)	Recent Studies (post-2010) (1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone)	Studies (lovastatin)	Trials (lovastatin)	Recent Studies (post-2010) (lovastatin)
23	1	0	4,828	698	873

Protein Interaction Comparison

Protein	Taxonomy	lovastatin (IC50)
Chain A, Antigen Cd11a (p180)	Homo sapiens (human)	2.4
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Homo sapiens (human)	0.0261
Integrin beta-2	Homo sapiens (human)	3.09
Intercellular adhesion molecule 1	Homo sapiens (human)	3.78
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	8.753
ATP-dependent translocase ABCB1	Homo sapiens (human)	10
Neutrophil elastase	Homo sapiens (human)	0.027
Insulin receptor	Rattus norvegicus (Norway rat)	0.02
Integrin alpha-L	Homo sapiens (human)	3.09
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	8.753
Prostaglandin G/H synthase 2	Homo sapiens (human)	0.02
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Rattus norvegicus (Norway rat)	0.0529

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Afonso, A; Burnett, DA; Clader, JW; Davis, HR; Huynh, T; Rosenblum, SB; Yumibe, N	1
Bays, H; Cuffie-Jackson, C; Davidson, MH; Dujovne, CA; Goldberg, AC; Hunninghake, DB; Jones, P; Knopp, R; Lipka, LJ; Stein, EA	1

Trials

1 trial(s) available for 1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone and lovastatin

Article	Year
Reduction of LDL cholesterol in patients with primary hypercholesterolemia by SCH 48461: results of a multicenter dose-ranging study. Journal of clinical pharmacology, 2001, Volume: 41, Issue:1 Topics: Anticholesteremic Agents; Apolipoprotein A-I; Azetidines; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Placebos; Triglycerides	2001

Article

Year

Reduction of LDL cholesterol in patients with primary hypercholesterolemia by SCH 48461: results of a multicenter dose-ranging study.

Journal of clinical pharmacology, 2001, Volume: 41, Issue:1

Topics: Anticholesteremic Agents; Apolipoprotein A-I; Azetidines; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Placebos; Triglycerides

2001

Other Studies

1 other study(ies) available for 1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone and lovastatin

Article	Year
Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption. Journal of medicinal chemistry, 1998, Mar-12, Volume: 41, Issue:6 Topics: Animals; Anticholesteremic Agents; Azetidines; Cholesterol; Cricetinae; Drug Design; Ezetimibe; Liver; Structure-Activity Relationship	1998

Article

Year

Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption.

Journal of medicinal chemistry, 1998, Mar-12, Volume: 41, Issue:6

Topics: Animals; Anticholesteremic Agents; Azetidines; Cholesterol; Cricetinae; Drug Design; Ezetimibe; Liver; Structure-Activity Relationship

1998