1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone has been researched along with ezetimibe in 10 studies
| Studies (1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone) | Trials (1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone) | Recent Studies (post-2010) (1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone) | Studies (ezetimibe) | Trials (ezetimibe) | Recent Studies (post-2010) (ezetimibe) |
|---|---|---|---|---|---|
| 23 | 1 | 0 | 2,484 | 563 | 1,465 |
| Protein | Taxonomy | 1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone (IC50) | ezetimibe (IC50) |
|---|---|---|---|
| NPC1-like intracellular cholesterol transporter 1 | Homo sapiens (human) | 0.37 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Afonso, A; Burnett, DA; Clader, JW; Davis, HR; Huynh, T; Rosenblum, SB; Yumibe, N | 1 |
| Davis, HR; Vaccaro, WD | 1 |
| Browne, ME; Burnett, DA; Caplen, MA; Clader, JW; Davis, HR; Domalski, MS | 1 |
| Altmann, SW; Browne, ME; Burnett, DA; Caplen, MA; Clader, JW; Davis, HR; Zhau, H | 1 |
| Carreira, EM; Hauser, H; Kvaernø, L; Werder, M | 1 |
| Mehta, PD; Pathak, AK; Sengar, NP | 1 |
| Alton, KB; Compton, DS; Davis, HR; France, CF; McLeod, RL; Sybertz, EJ; Van Heek, M; Yumibe, NP | 1 |
| Corsiero, D; Girbig, F; Glombik, H; Heuer, H; Kramer, W; Petry, S; Schäfer, H; Wendler, W; Weyland, C | 1 |
| Compton, DS; Davis, HR; van Heek, M | 1 |
| Clader, JW | 1 |
2 review(s) available for 1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone and ezetimibe
| Article | Year |
|---|---|
2-Azetidinone--a new profile of various pharmacological activities.
Topics: Animals; Anti-Infective Agents; Antifungal Agents; Antiparkinson Agents; Azetidines; Humans; Hypoglycemic Agents | 2010 |
The discovery of ezetimibe: a view from outside the receptor.
Topics: Absorption; Animals; Anticholesteremic Agents; Azetidines; Cholesterol; Clinical Trials as Topic; Drug Design; Drug Therapy, Combination; Ezetimibe; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors | 2004 |
8 other study(ies) available for 1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone and ezetimibe
| Article | Year |
|---|---|
Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption.
Topics: Animals; Anticholesteremic Agents; Azetidines; Cholesterol; Cricetinae; Drug Design; Ezetimibe; Liver; Structure-Activity Relationship | 1998 |
Sugar-substituted 2-azetidinone cholesterol absorption inhibitors: enhanced potency by modification of the sugar.
Topics: Animals; Anticholesteremic Agents; Azetidines; Carbohydrates; Cholesterol; Chromatography, High Pressure Liquid; Cricetinae; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Structure-Activity Relationship | 1998 |
Synthesis of iodinated biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.
Topics: Animals; Anticholesteremic Agents; Azetidines; Cholesterol; Cricetinae; Drug Design; Ezetimibe; Intestinal Absorption; Isotope Labeling; Stereoisomerism; Structure-Activity Relationship | 2002 |
Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.
Topics: Animals; Anticholesteremic Agents; Azetidines; Catalysis; Cholesterol; Drug Design; Ezetimibe; Fluorescent Dyes; Intestinal Absorption; Male; Palladium; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship | 2002 |
Synthesis and in vitro evaluation of inhibitors of intestinal cholesterol absorption.
Topics: Animals; Anticholesteremic Agents; Azetidines; beta-Lactams; Cholesterol; Ezetimibe; Glycosides; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Microvilli; Models, Molecular; Rabbits; Structure-Activity Relationship | 2005 |
In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461.
Topics: Absorption; Animals; Anticholesteremic Agents; Azetidines; Bile; Cholesterol; Cholesterol, LDL; Dose-Response Relationship, Drug; Ezetimibe; Macaca mulatta; Male; Rats; Rats, Sprague-Dawley | 1997 |
Identification of binding proteins for cholesterol absorption inhibitors as components of the intestinal cholesterol transporter.
Topics: Animals; Anticholesteremic Agents; Azetidines; Bile Acids and Salts; Carrier Proteins; Cephalexin; Cholesterol; Drug Design; Ezetimibe; Fatty Acids; Glucose; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Microvilli; Rabbits; Structure-Activity Relationship | 2000 |
The cholesterol absorption inhibitor, ezetimibe, decreases diet-induced hypercholesterolemia in monkeys.
Topics: Animals; Anticholesteremic Agents; Azetidines; Cholesterol; Cholesterol Esters; Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Ezetimibe; Female; Hypercholesterolemia; Macaca fascicularis; Macaca mulatta; Male; Time Factors; Triglycerides | 2001 |