Compounds > 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
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1,4-bis(2-(3,5-dichloropyridyloxy))benzene and pregnenolone carbonitrile

1,4-bis(2-(3,5-dichloropyridyloxy))benzene has been researched along with pregnenolone carbonitrile in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.25)18.7374
1990's1 (6.25)18.2507
2000's3 (18.75)29.6817
2010's11 (68.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baucom, CC; Chang, TK; Lau, AJ; Rajaraman, G; Yang, G1
Kelley, M; Safe, S; Womack, J1
Gerstner, E; Heubel, F; Reuter, T1
Handschin, C; Hoffmann, K; Meyer, UA; Podvinec, M; Stöckli, J1
Felmlee, MA; Gonzalez, FJ; Lon, HK; Yu, AM1
Aleksunes, LM; Beilke, LD; Besselsen, DG; Cherrington, NJ; Dvorak, K; Klaassen, CD; Olson, ER1
Fujino, H; Kataoka, H; Kugawa, F; Moriya, N; Nishikawa, J1
Benoki, S; Kodama, S; Miyata, M; Numakura, Y; Shizu, R; Yamazoe, Y; Yoshinari, K1
Bainy, AC; Goldstone, JV; Kubota, A; Stegeman, JJ; Woodin, BR1
Aleksunes, LM; Baker, AA; Guo, GL; Richardson, JR1
Cui, JY; Klaassen, CD; Li, CY; Renaud, HJ1
Cui, JY; Klaassen, CD1
Kataoka, H; Kugawa, F; Moriya, N; Nishikawa, J1
Dempsey, JL; Fei, Q; Gu, H; Raftery, D; Siginir, G; Wang, D; Yue Cui, J1
Horiguchi, N; Kakizaki, S; Sato, K; Takizawa, D; Tojima, H; Uehara, D; Uraoka, T; Yamada, M; Yamazaki, Y1
Cui, JY; Dempsey, JL1

Other Studies

16 other study(ies) available for 1,4-bis(2-(3,5-dichloropyridyloxy))benzene and pregnenolone carbonitrile

ArticleYear
Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; Cell Line, Tumor; Cells, Cultured; Constitutive Androstane Receptor; Cyclopentanes; Furans; Ginkgolides; Hep G2 Cells; Hepatocytes; Humans; Pregnane X Receptor; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Species Specificity

2012
Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins.
    Biochemical pharmacology, 1990, Jun-15, Volume: 39, Issue:12

    Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Activation; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Oxazines; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Safrole; Testosterone

1990
Differences between induction effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and phenobarbitone.
    Biochemical pharmacology, 1989, Apr-15, Volume: 38, Issue:8

    Topics: Animals; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Induction; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Rifampin; Warfarin

1989
Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans.
    Molecular endocrinology (Baltimore, Md.), 2001, Volume: 15, Issue:9

    Topics: Animals; Avian Proteins; beta-Naphthoflavone; Cell Line; Chickens; Clotrimazole; Colforsin; Constitutive Androstane Receptor; Cyclic AMP; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; Glutethimide; Growth Inhibitors; Hormone Antagonists; Humans; Metyrapone; Mifepristone; Okadaic Acid; Pregnane X Receptor; Pregnenolone Carbonitrile; Protein Binding; Pyridines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Rifampin; Signal Transduction; Trans-Activators; Transcription Factors

2001
Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:2

    Topics: Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Humans; Male; Mice; Mice, Transgenic; Microsomes; Midazolam; Pregnenolone Carbonitrile; Pyridines; Testosterone

2008
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
    Toxicology letters, 2009, Jul-10, Volume: 188, Issue:1

    Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cholestasis, Intrahepatic; Constitutive Androstane Receptor; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Phenobarbital; Pregnenolone Carbonitrile; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiones; Thiophenes; Transcription Factors

2009
Effect of lipopolysaccharide on the xenobiotic-induced expression and activity of hepatic cytochrome P450 in mice.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:4

    Topics: Animals; Benzo(a)pyrene; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Inflammation; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; Pregnane X Receptor; Pregnenolone Carbonitrile; Pyridines; Real-Time Polymerase Chain Reaction; Receptors, Aryl Hydrocarbon; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Xenobiotics

2012
Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Animals; Cell Proliferation; Constitutive Androstane Receptor; Gene Expression Regulation; Hepatocytes; Injections, Intraperitoneal; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenobarbital; PPAR alpha; Pregnane X Receptor; Pregnenolone Carbonitrile; Primary Cell Culture; Pyridines; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Signal Transduction; Xenobiotics

2013
The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers.
    Toxicology and applied pharmacology, 2013, Oct-01, Volume: 272, Issue:1

    Topics: Animals; Biological Evolution; Cloning, Molecular; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Gene Expression Regulation, Enzymologic; Male; Models, Molecular; Organ Specificity; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Xenobiotics; Zebrafish; Zebrafish Proteins

2013
Isoform-Specific Regulation of Mouse Carboxylesterase Expression and Activity by Prototypical Transcriptional Activators.
    Journal of biochemical and molecular toxicology, 2015, Volume: 29, Issue:12

    Topics: Animals; Carboxylesterase; Gene Expression Regulation, Enzymologic; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Pregnenolone Carbonitrile; Pyridines; RNA, Messenger; Trans-Activators

2015
Age-Specific Regulation of Drug-Processing Genes in Mouse Liver by Ligands of Xenobiotic-Sensing Transcription Factors.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:7

    Topics: Age Factors; Aldehyde Dehydrogenase; Animals; Animals, Newborn; Basic Helix-Loop-Helix Transcription Factors; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Glutathione Transferase; Ligands; Liver; Male; Mice, Inbred C57BL; Organic Cation Transport Proteins; Polychlorinated Dibenzodioxins; Pregnane X Receptor; Pregnenolone Carbonitrile; Pyridines; Receptors, Aryl Hydrocarbon; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Sulfotransferases

2016
RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.
    Biochimica et biophysica acta, 2016, Volume: 1859, Issue:9

    Topics: Animals; Constitutive Androstane Receptor; Corn Oil; Gene Expression Profiling; Gene Expression Regulation; Gene Library; Gene Ontology; High-Throughput Nucleotide Sequencing; Injections, Intraperitoneal; Ligands; Liver; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Molecular Sequence Annotation; Pregnane X Receptor; Pregnenolone Carbonitrile; Pyridines; Receptors, Aryl Hydrocarbon; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Signal Transduction; Transcriptome

2016
Identification of Candidate Target Cyp Genes for microRNAs Whose Expression Is Altered by PCN and TCPOBOP, Representative Ligands of PXR and CAR.
    Biological & pharmaceutical bulletin, 2016, Aug-01, Volume: 39, Issue:8

    Topics: Animals; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Liver; Male; Mice, Inbred BALB C; MicroRNAs; Pregnenolone Carbonitrile; Pyridines; RNA, Messenger

2016
Pharmacological Activation of PXR and CAR Downregulates Distinct Bile Acid-Metabolizing Intestinal Bacteria and Alters Bile Acid Homeostasis.
    Toxicological sciences : an official journal of the Society of Toxicology, 2019, 03-01, Volume: 168, Issue:1

    Topics: Animals; Bacteria; Bile Acids and Salts; Cholesterol 7-alpha-Hydroxylase; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Down-Regulation; Gastrointestinal Microbiome; Homeostasis; Intestine, Large; Liver; Male; Mice; Mice, Inbred C57BL; Pregnane X Receptor; Pregnenolone Carbonitrile; Pyridines; Receptors, Cytoplasmic and Nuclear

2019
Constitutive androstane receptor and pregnane X receptor cooperatively ameliorate DSS-induced colitis.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2019, Volume: 51, Issue:2

    Topics: Animals; Antigens, Differentiation; Apoptosis; Colitis; Constitutive Androstane Receptor; Dextran Sulfate; Disease Models, Animal; Inflammation; Interleukin-1beta; Mice; Pregnane X Receptor; Pregnenolone Carbonitrile; Pyridines; Receptors, Cytoplasmic and Nuclear; Tumor Necrosis Factor-alpha

2019
Regulation of Hepatic Long Noncoding RNAs by Pregnane X Receptor and Constitutive Androstane Receptor Agonists in Mouse Liver.
    Drug metabolism and disposition: the biological fate of chemicals, 2019, Volume: 47, Issue:3

    Topics: Animals; Constitutive Androstane Receptor; Epigenesis, Genetic; Gene Expression Regulation; Histones; Liver; Male; Mice; Mice, Inbred C57BL; Pregnane X Receptor; Pregnenolone Carbonitrile; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Long Noncoding; Sequence Analysis, RNA; Transcriptional Activation; Xenobiotics

2019