1,4-bis(2-(3,5-dichloropyridyloxy))benzene and phenobarbital

1,4-bis(2-(3,5-dichloropyridyloxy))benzene has been researched along with phenobarbital in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (19.51)	18.7374
1990's	8 (19.51)	18.2507
2000's	13 (31.71)	29.6817
2010's	12 (29.27)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Auriola, S; Honkakoski, P; Lang, MA	1
Colombo, BM; Dragani, TA; Falquerho, L; Le Cam, A; Manenti, G	1
Chistiakov, VV; Gutkina, NI; Liakhovich, VV; Mishin, VM; Pospelova, LN	1
Kelley, M; Safe, S; Womack, J	1
Della Porta, G; Dragani, TA; Manenti, G	1
Gerstner, E; Heubel, F; Reuter, T	1
Gelboin, HV; Honkakoski, P; Järvinen, P; Juvonen, R; Kojo, A; Lang, MA; Park, SS; Pelkonen, O; Raunio, H; Vähäkangas, K	1
Duzhak, TG; Gutkina, NI; Liakhovich, VV; Tsyrlov, IB	1
Fonné, R; Meyer, UA	1
Della Porta, G; Dragani, TA; Galliani, G; Manenti, G	1
Kelley, M; Lambert, I; Merrill, J; Safe, S	1
Boatman, RJ; Ebetino, FH; Glover, E; Kende, AS; Mak, I; Poland, A	1
Dragnev, KH; Jones, CR; Lubet, RA; Mellini, DW; Nims, RW; Sinclair, JF; Sinclair, PR; Thomas, PE	1
Bars, RG; Henderson, CJ; Parker, MG; Smith, G; White, R; Wolf, CR	1
Gynther, J; Honkakoski, P; Moore, R; Negishi, M	1
Honkakoski, P; Moore, R; Negishi, M; Washburn, KA	1
Egan-Hafley, M; Liang, S; Moore, DD; Wei, P; Zhang, J	1
Oliver, JD; Roberts, RA	1
Chua, SS; Huang, W; Moore, DD; Wei, P; Zhang, J	1
Duzhak, TG; Gulyaeva, LF; Lyakhovich, VV; Schwartz, EI	1
Brewer, HB; Gonzalez, FJ; Guo, GL; Kliewer, SA; Lambert, G; Negishi, M; Sinal, CJ; Ward, JM	1
Moore, DD; Qatanani, M; Zhang, J	1
Hosseinpour, F; Moore, R; Negishi, M; Sueyoshi, T	1
Gulyaeva, LF; Lebedev, AN; Lyakhovich, VV; Pustylnyak, VO; Slynko, NM	1
Horigichi, N; Horiguchi, N; Kakizaki, S; Kosone, T; Mori, M; Sato, K; Sohara, N; Takagi, H; Yamazaki, Y; Yoshinari, K	1
Beilke, LD; Besselsen, DG; Cheng, Q; Cherrington, NJ; Kulkarni, S; Slitt, AL	1
Aleksunes, LM; Beger, RD; Beilke, LD; Besselsen, DG; Cherrington, NJ; Holland, RD; Klaassen, CD	1
Braeuning, A; Huelsken, J; Sanna, R; Schwarz, M	1
Aleksunes, LM; Beilke, LD; Besselsen, DG; Cherrington, NJ; Dvorak, K; Klaassen, CD; Olson, ER	1
Breuker, C; Lakhal, L; Lumbroso, S; Maurel, P; Meyer, U; Moreau, A; Parmentier, Y; Pascussi, JM; Tamasi, V; Vilarem, MJ	1
Min, G	1
Bell, AW; Bhave, VS; Bowen, WC; Donthamsetty, S; Kang, LI; Lin, CW; Mars, WM; Michalopoulos, GK; Orr, A; Paranjpe, S	1
Braeuning, A; Columbano, A; Heubach, Y; Knorpp, T; Kowalik, MA; Schwarz, M; Templin, M	1
Halwachs, S; Honscha, W; Schaefer, I; Seibel, P	1
Benoki, S; Kodama, S; Miyata, M; Numakura, Y; Shizu, R; Yamazoe, Y; Yoshinari, K	1
Bainy, AC; Goldstone, JV; Kubota, A; Stegeman, JJ; Woodin, BR	1
Bainy, AC; Celander, MC; Goksøyr, A; Goldstone, JV; Hahn, ME; Karchner, SI; Kubota, A; Lille-Langøy, R; Stegeman, JJ	1
Negishi, M; Timsit, YE	1
Ahmed, MM; El-Shazly, SA; Fujita, S; Ibrahim, ZS; Ishizuka, M	1
Ducheix, S; Gamet-Payrastre, L; Gerbal-Chaloin, S; Goron, A; Guillou, H; Lasserre, F; Lukowicz, C; Marmugi, A; Moldes, M; Montagner, A; Mselli-Lakhal, L; Pascussi, JM; Pineau, T; Polizzi, A	1
Andersen, ME; Cowie, DE; Deisenroth, C; LeCluyse, E; Peffer, RC; Soldatow, V; Trask, OJ	1

Reviews

1 review(s) available for 1,4-bis(2-(3,5-dichloropyridyloxy))benzene and phenobarbital

Article	Year
Receptor-mediated hepatocarcinogenesis: role of hepatocyte proliferation and apoptosis. Pharmacology & toxicology, 2002, Volume: 91, Issue:1 Topics: Animals; Apoptosis; Carcinogens; Cell Division; Dieldrin; Dioxins; Hepatocytes; Liver; Liver Neoplasms; Peroxisome Proliferators; Phenobarbital; Polychlorinated Biphenyls; Pyridines; Receptors, Cytoplasmic and Nuclear; Rodentia	2002

Other Studies

40 other study(ies) available for 1,4-bis(2-(3,5-dichloropyridyloxy))benzene and phenobarbital

Article	Year
Distinct induction profiles of three phenobarbital-responsive mouse liver cytochrome P450 isozymes. Biochemical pharmacology, 1992, May-28, Volume: 43, Issue:10 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Isoenzymes; Liver; Mice; Mice, Inbred DBA; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; RNA, Messenger; Steroid Hydroxylases	1992
Expression of the pp63 gene encoding the insulin receptor tyrosine kinase inhibitor in proliferating liver and in liver tumors. Biochemical and biophysical research communications, 1991, Oct-31, Volume: 180, Issue:2 Topics: alpha-2-HS-Glycoprotein; Animals; Cell Division; Crosses, Genetic; Female; Gene Expression; Glycoproteins; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Phenobarbital; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Inbred Strains; Receptor, Insulin; RNA, Messenger	1991
[Comparison of the inducing effect of triphenyldioxan, bis-(dichloropyridyloxy)benzene and phenobarbital on the liver monooxygenase]. Biokhimiia (Moscow, Russia), 1990, Volume: 55, Issue:1 Topics: Animals; Cytochrome P-450 Enzyme System; Dioxanes; Dioxins; Enzyme Induction; Isoenzymes; Male; Microsomes, Liver; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains	1990
Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins. Biochemical pharmacology, 1990, Jun-15, Volume: 39, Issue:12 Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Activation; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Oxazines; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Safrole; Testosterone	1990
Effects of phenobarbital and 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene on differentiated functions in mouse liver. Chemico-biological interactions, 1987, Volume: 64, Issue:1-2 Topics: Animals; Cell Differentiation; Female; gamma-Glutamyltransferase; Glucocorticoids; Glucose-6-Phosphatase; Liver; Metallothionein; Mice; Mice, Inbred C3H; Phenobarbital; Pyridines; RNA; Transcription, Genetic; Tyrosine Transaminase	1987
Differences between induction effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and phenobarbitone. Biochemical pharmacology, 1989, Apr-15, Volume: 38, Issue:8 Topics: Animals; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Induction; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Rifampin; Warfarin	1989
Mouse hepatic cytochrome P-450 isozyme induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, pyrazole, and phenobarbital. Biochemical pharmacology, 1988, Nov-01, Volume: 37, Issue:21 Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Cytochrome P-450 Enzyme System; Enzyme Induction; Glutamate-Cysteine Ligase; Isoenzymes; Mice; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Phenobarbital; Pyrazoles; Pyridines	1988
[Comparison of cytochrome P-450 forms induced by phenobarbital and 1,4-bis[3,5-dichloropyridyloxy)]benzene in the mouse and rat liver]. Biokhimiia (Moscow, Russia), 1988, Volume: 53, Issue:2 Topics: Animals; Chromatography, Affinity; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Molecular Weight; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains; Species Specificity	1988
Mechanisms of phenobarbital-type induction of cytochrome P-450 isozymes. Pharmacology & therapeutics, 1987, Volume: 33, Issue:1 Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Male; Mice; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains	1987
Promoting effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene in mouse hepatocarcinogenesis. Carcinogenesis, 1985, Volume: 6, Issue:2 Topics: Adenoma; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA; Female; Liver Neoplasms, Experimental; Mice; Mice, Inbred Strains; Oxidoreductases, N-Demethylating; Oxidoreductases, O-Demethylating; Phenobarbital; Pyridines	1985
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) and related compounds as inducers of hepatic monooxygenases. Structure-activity effects. Biochemical pharmacology, 1985, Oct-01, Volume: 34, Issue:19 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Mice; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Structure-Activity Relationship	1985
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity. Molecular pharmacology, 1980, Volume: 18, Issue:3 Topics: Adipose Tissue; Animals; Enzyme Induction; Female; In Vitro Techniques; Male; Maternal-Fetal Exchange; Mice; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Pregnancy; Pyridines	1980
Dose-response relationships for the induction of P450 2B by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzne (TCPOBOP) in rat and cultured rat hepatocytes. Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:12 Topics: Animals; Base Sequence; Cells, Cultured; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; DNA Probes; Dose-Response Relationship, Drug; Enzyme Induction; Epoxide Hydrolases; Glutathione Transferase; Liver; Male; Molecular Sequence Data; Oxidoreductases; Phenobarbital; Pyridines; Rats; Rats, Inbred F344; RNA	1993
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression. The Biochemical journal, 1993, Feb-01, Volume: 289 ( Pt 3) Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Gene Expression Regulation, Enzymologic; Liver; Male; Metallothionein; Mice; Mice, Inbred DBA; Microsomes, Liver; Oxazines; Phenobarbital; Protein Biosynthesis; Proteins; Pyridines; Recombinant Fusion Proteins; Repetitive Sequences, Nucleic Acid; RNA, Messenger; Transcription, Genetic; Transfection	1993
Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes. The Journal of biological chemistry, 1996, Apr-19, Volume: 271, Issue:16 Topics: Animals; Base Sequence; Cell Nucleus; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Consensus Sequence; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; DNA Primers; Enzyme Induction; Gene Expression Regulation, Enzymologic; Introns; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Sequence Data; Organ Specificity; Oxidoreductases; Phenobarbital; Polymerase Chain Reaction; Promoter Regions, Genetic; Pyridines; Rats; Recombinant Proteins; Repetitive Sequences, Nucleic Acid; Sequence Deletion; TATA Box; Transcription, Genetic; Transfection	1996
Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene. Molecular pharmacology, 1998, Volume: 53, Issue:4 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Composition; Camphor; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enhancer Elements, Genetic; Enzyme Activation; Gene Expression Regulation; Liver; Male; Mice; Mice, Inbred C57BL; Pesticides; Phenobarbital; Polychlorinated Biphenyls; Pyridines; Solvents; Steroid Hydroxylases; Xenobiotics	1998
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature, 2000, Oct-19, Volume: 407, Issue:6806 Topics: Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Cell Line; Cocaine; Coxsackie and Adenovirus Receptor-Like Membrane Protein; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Induction; Female; Gene Expression Regulation, Enzymologic; Gene Targeting; Humans; Liver; Male; Mice; Pharmaceutical Preparations; Phenobarbital; Pyridines; Receptors, Virus; Steroid Hydroxylases; Xenobiotics; Zoxazolamine	2000
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science (New York, N.Y.), 2002, Oct-11, Volume: 298, Issue:5592 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Androstanols; Animals; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Constitutive Androstane Receptor; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Imines; Isoenzymes; Liver; Mice; Mice, Knockout; Mice, Transgenic; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Time Factors; Transcription Factors	2002
Inducer effect on the complex formation between rat liver nuclear proteins and cytochrome P450 2B gene regulatory elements. Biochemistry. Biokhimiia, 2002, Volume: 67, Issue:9 Topics: Animals; Binding, Competitive; Cytochrome P-450 CYP2B1; Dioxanes; DNA; Electrophoretic Mobility Shift Assay; Enzyme Induction; Gene Expression Regulation, Enzymologic; Liver; Male; Nuclear Proteins; Phenobarbital; Pyridines; Rats; Rats, Wistar; Regulatory Sequences, Nucleic Acid; Signal Transduction; Time Factors; Transcriptional Activation	2002
Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. The Journal of biological chemistry, 2003, Nov-14, Volume: 278, Issue:46 Topics: Animal Feed; Animals; Aryl Hydrocarbon Hydroxylases; Bile Acids and Salts; Bilirubin; Biological Transport; Blotting, Northern; Body Weight; Cell Nucleus; Cholesterol; Cloning, Molecular; Constitutive Androstane Receptor; Crosses, Genetic; Cytochrome P-450 CYP3A; DNA-Binding Proteins; Gene Deletion; Glutathione Transferase; Lipid Metabolism; Liver; Mice; Mice, Transgenic; Mitochondrial Proteins; Oxidoreductases, N-Demethylating; Phenobarbital; Phospholipids; Pregnane X Receptor; Pyridines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Time Factors; Transcription Factors; Up-Regulation	2003
Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism. Endocrinology, 2005, Volume: 146, Issue:3 Topics: Animals; Anticonvulsants; Blotting, Northern; Cell Proliferation; Constitutive Androstane Receptor; Dose-Response Relationship, Drug; Female; Humans; Immunohistochemistry; Male; Mice; Models, Biological; Mutation; Phenobarbital; Proliferating Cell Nuclear Antigen; Propylthiouracil; Pyridines; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Thyroid Hormones; Thyroid Neoplasms; Thyroxine; Transcription Factors; Triiodothyronine; Xenobiotics	2005
Serine 202 regulates the nuclear translocation of constitutive active/androstane receptor. Molecular pharmacology, 2006, Volume: 69, Issue:4 Topics: Amino Acid Sequence; Animals; Cell Line; Cell Nucleus; Constitutive Androstane Receptor; Mice; Molecular Sequence Data; Phenobarbital; Phosphorylation; Protein Transport; Pyridines; Receptors, Cytoplasmic and Nuclear; Sequence Homology, Amino Acid; Serine; Transcription Factors	2006
Comparative study of CYP2B induction in the liver of rats and mice by different compounds. Life sciences, 2007, Jan-02, Volume: 80, Issue:4 Topics: Animals; Blotting, Western; Cytochrome P-450 CYP2B1; Dioxanes; Enzyme Induction; Liver; Male; Mice; Mice, Inbred C57BL; Models, Animal; Phenobarbital; Pyridines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Species Specificity; Transcriptional Activation; Xenobiotics	2007
Gene expression profiles of drug-metabolizing enzymes and transporters with an overexpression of hepatocyte growth factor. Liver international : official journal of the International Association for the Study of the Liver, 2007, Volume: 27, Issue:1 Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Profiling; Hepatocyte Growth Factor; Liver; Male; Mice; Mice, Transgenic; Microsomes, Liver; Oligonucleotide Array Sequence Analysis; Phenobarbital; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger	2007
Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis. Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 102, Issue:1 Topics: Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholestasis, Intrahepatic; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Phenobarbital; Protective Agents; Pyrazines; Pyridines; RNA, Messenger; Symporters; Thiones; Thiophenes; Time Factors; Up-Regulation	2008
Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:5 Topics: Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Constitutive Androstane Receptor; DNA; DNA-Binding Proteins; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Probes; Phenobarbital; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Transcription Factors	2009
Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:5 Topics: Animals; beta Catenin; Blotting, Western; Constitutive Androstane Receptor; Cytochrome P-450 CYP2E1; Enzyme Induction; Female; Hepatocytes; Immunohistochemistry; Liver; Male; Mice; Mice, Knockout; NF-E2-Related Factor 2; Pharmaceutical Preparations; Phenobarbital; Pregnane X Receptor; Pyridines; Receptors, Aryl Hydrocarbon; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors; Xenobiotics	2009
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice. Toxicology letters, 2009, Jul-10, Volume: 188, Issue:1 Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cholestasis, Intrahepatic; Constitutive Androstane Receptor; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Phenobarbital; Pregnenolone Carbonitrile; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiones; Thiophenes; Transcription Factors	2009
Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3). Endocrinology, 2010, Volume: 151, Issue:4 Topics: Adult; Aged; Analysis of Variance; Animals; Blotting, Western; Cells, Cultured; Constitutive Androstane Receptor; Electrophoretic Mobility Shift Assay; Female; Gene Expression Regulation; Humans; Liver; Male; Mice; Middle Aged; Nuclear Proteins; Oximes; Phenobarbital; Promoter Regions, Genetic; Pyridines; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Transcription Factors; Transcriptional Activation; Transfection	2010
Estrogen modulates transactivations of SXR-mediated liver X receptor response element and CAR-mediated phenobarbital response element in HepG2 cells. Experimental & molecular medicine, 2010, Nov-30, Volume: 42, Issue:11 Topics: Constitutive Androstane Receptor; Corticosterone; Estrogens; Ethinyl Estradiol; Hep G2 Cells; Humans; Liver; Liver X Receptors; Orphan Nuclear Receptors; Phenobarbital; Pregnane X Receptor; Pyridines; Receptor Cross-Talk; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Response Elements; Rifampin; Transcriptional Activation	2010
Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice. Hepatology (Baltimore, Md.), 2011, Volume: 54, Issue:2 Topics: Animals; Cell Proliferation; Gene Expression Regulation; Genes, cdc; Glypicans; Hepatocytes; Hepatomegaly; Mice; Mice, Transgenic; Phenobarbital; Pyridines	2011
Gender-specific interplay of signaling through β-catenin and CAR in the regulation of xenobiotic-induced hepatocyte proliferation. Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 123, Issue:1 Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; beta Catenin; Cell Proliferation; Female; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression Regulation; Hepatocytes; Male; Mice; Mice, Knockout; Phenobarbital; Protein Array Analysis; Protein Serine-Threonine Kinases; Pyridines; Recoverin; Ribosomal Protein S6 Kinases, 90-kDa; Sex Factors; Wnt Signaling Pathway	2011
Antiepileptic drugs reduce the efficacy of methotrexate chemotherapy through accelerated degradation of the reduced folate carrier by the ubiquitin-proteasome pathway. Chemotherapy, 2011, Volume: 57, Issue:4 Topics: Animals; Anticonvulsants; Antimetabolites, Antineoplastic; Biosynthetic Pathways; Cell Line; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Drug Interactions; Half-Life; Methotrexate; Phenobarbital; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase C; Pyridines; Rats; Receptors, Cytoplasmic and Nuclear; Reduced Folate Carrier Protein; Replication Protein C; Repressor Proteins; Ubiquitin	2011
Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice. PloS one, 2013, Volume: 8, Issue:4 Topics: Animals; Cell Proliferation; Constitutive Androstane Receptor; Gene Expression Regulation; Hepatocytes; Injections, Intraperitoneal; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenobarbital; PPAR alpha; Pregnane X Receptor; Pregnenolone Carbonitrile; Primary Cell Culture; Pyridines; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Signal Transduction; Xenobiotics	2013
The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Toxicology and applied pharmacology, 2013, Oct-01, Volume: 272, Issue:1 Topics: Animals; Biological Evolution; Cloning, Molecular; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Gene Expression Regulation, Enzymologic; Male; Models, Molecular; Organ Specificity; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Xenobiotics; Zebrafish; Zebrafish Proteins	2013
Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands), 2013, Oct-15, Volume: 142-143 Topics: Alleles; Animals; Brain; Constitutive Androstane Receptor; Eye; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Order; Liver; Male; Molecular Sequence Data; Phenobarbital; Phylogeny; Pregnane X Receptor; Protein Binding; Pyridines; Receptors, Steroid; Water Pollutants, Chemical; Zebrafish	2013
Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system. PloS one, 2014, Volume: 9, Issue:5 Topics: Animals; Constitutive Androstane Receptor; Cytoplasm; Dose-Response Relationship, Drug; Heat-Shock Proteins; Heat-Shock Response; Hep G2 Cells; HSP70 Heat-Shock Proteins; Humans; Leupeptins; Ligands; Mice; Molecular Chaperones; Phenobarbital; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyridines; Receptors, Cytoplasmic and Nuclear; Transcriptional Activation; Ubiquitin; Ubiquitination	2014
Clofibric acid induces hepatic CYP 2B1/2 via constitutive androstane receptor not via peroxisome proliferator activated receptor alpha in rat. Bioscience, biotechnology, and biochemistry, 2014, Volume: 78, Issue:9 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Clofibric Acid; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B1; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Humans; Insulin; Liver; Mice; Phenobarbital; PPAR alpha; Pyridines; Rats; Receptors, Cytoplasmic and Nuclear; Steroid Hydroxylases	2014
Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way. Toxicology and applied pharmacology, 2016, 07-15, Volume: 303 Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Line; Cells, Cultured; Constitutive Androstane Receptor; Fatty Liver; Female; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Lipase; Lipogenesis; Liver; Liver X Receptors; Male; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; Nuclear Proteins; Phenobarbital; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors	2016
Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation. Toxicology in vitro : an international journal published in association with BIBRA, 2016, Volume: 36 Topics: Acetaminophen; Animals; Aryl Hydrocarbon Hydroxylases; Biological Assay; Cell Proliferation; Cell Survival; Cells, Cultured; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; DNA; Epidermal Growth Factor; Hepatocytes; Humans; Male; Membrane Proteins; Mice; Microscopy, Fluorescence; Oximes; Phenobarbital; Pyridines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Species Specificity; Steroid Hydroxylases; Thiazoles	2016