1,3-ditolylguanidine has been researched along with phencyclidine in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 12 (48.00) | 18.2507 |
| 2000's | 4 (16.00) | 29.6817 |
| 2010's | 3 (12.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Campbell, BG; Kimes, AS; London, ED; Scheffel, U; Wilson, AA | 1 |
| Weigl, M; Wünsch, B | 1 |
| Köhler, J; Utech, T; Wünsch, B | 1 |
| Amantini, C; Barocelli, E; Bertoni, S; Bonifazi, A; Cimarelli, C; Del Bello, F; Flammini, L; Mammoli, V; Nabissi, M; Pellei, M; Petrelli, R; Piergentili, A; Quaglia, W; Santoni, G; Schepmann, D; Vistoli, G; Wünsch, B | 1 |
| Bickford, PC; Kim, M | 1 |
| Friedl, A; Georg, A | 1 |
| Dragunow, M; Faull, RL; Jansen, KL; Leslie, RA | 1 |
| Brent, PJ | 1 |
| Lipton, P; Lobner, D | 1 |
| Boksa, P; Chaudieu, I; Mount, H; Quirion, R | 1 |
| Connick, JH; Fox, PK; France, L; Hanlon, GM; Nicholson, CD | 1 |
| Bueno, L; Fioramonti, J; Gue, M; Junien, JL; Pascaud, X | 1 |
| Holtzman, SG | 1 |
| Denavit-Saubié, M; Foutz, AS | 1 |
| Bowen, WD; de Costa, BR; Hellewell, SB; Jacobson, AE; Rice, KC; Thurkauf, A; Walker, JM | 1 |
| Battaglia, G; De Souza, EB; Jaffe, JH; Kulsakdinun, C; Wolfe, SA | 1 |
| Chavkin, C; Malouf, AT; Swearengen, E | 1 |
| Contreras, ML; Contreras, PC; Lair, CC; O'Donohue, TL | 1 |
| Burge, LJ; Scalzo, FM | 1 |
| Chiodo, LA; Freeman, AS; Zhang, J | 1 |
| Brum, JM; Estafanous, FG; Murray, PA; Schubert, A; Tsuchida, H | 1 |
| Aoki, K; Narita, M; Nomura, M; Suzuki, T; Yoshizawa, K | 1 |
| Cuevas, J; Zhang, H | 1 |
| Cuevas, J; Guerrero, WR; Herrera, Y; Katnik, C; Pennypacker, KR | 1 |
| Behensky, A; Cuevas, J; Deng, W; Katnik, C | 1 |
25 other study(ies) available for 1,3-ditolylguanidine and phencyclidine
| Article | Year |
|---|---|
Radiosynthesis, cerebral distribution, and binding of [125I]-1-(p-iodophenyl)-3-(1-adamantyl)guanidine, a ligand for sigma binding sites.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Guanidines; Guinea Pigs; Iodobenzenes; Male; Mice; Receptors, sigma; Tissue Distribution | 1992 |
Synthesis of bridged piperazines with sigma receptor affinity.
Topics: Cross-Linking Reagents; Molecular Structure; Piperazine; Piperazines; Receptors, sigma | 2007 |
Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists.
Topics: Animals; Brain; Dioxanes; Molecular Structure; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Stereoisomerism; Structure-Activity Relationship; Swine | 2011 |
Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring.
Topics: Analgesics; Animals; Binding Sites; Dioxanes; Drug Design; Ligands; Mice; Models, Molecular; Pain; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor | 2015 |
Electrophysiological effects of phencyclidine and the sigma agonist ditolylguanidine in the cerebellum of the rat.
Topics: Animals; Cerebellum; Electrophysiology; Guanidines; Haloperidol; Male; Norepinephrine; Oxidopamine; Phencyclidine; Purkinje Fibers; Rats; Rats, Inbred Strains; Synaptic Transmission | 1992 |
Identification and characterization of two sigma-like binding sites in the mouse neuroblastoma x rat glioma hybrid cell line NG108-15.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Glioma; Guanidines; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Phencyclidine; Rats; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Tritium; Tumor Cells, Cultured | 1991 |
Autoradiographic visualisation of [3H]DTG binding to sigma receptors, [3H]TCP binding sites, and L-[3H]glutamate binding to NMDA receptors in human cerebellum.
Topics: Autoradiography; Female; Glutamates; Glutamic Acid; Guanidines; Humans; Male; Middle Aged; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Tritium | 1991 |
Similar behavioural effects of sigma agonists and PCP-like non-competitive NMDA antagonists in guinea-pigs.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzamides; Dizocilpine Maleate; Dopamine Agents; Dopamine Antagonists; Ergolines; Female; Guanidines; Guinea Pigs; Haloperidol; Ketamine; Male; Motor Activity; N-Methylaspartate; Pentazocine; Phenazocine; Phencyclidine; Quinpirole; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma; Remoxipride | 1991 |
Sigma-ligands and non-competitive NMDA antagonists inhibit glutamate release during cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cyclazocine; Dizocilpine Maleate; Glutamates; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Ketamine; Kynurenic Acid; Male; Models, Neurological; Phencyclidine; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma | 1990 |
Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Binding Sites; Cells, Cultured; Dioxolanes; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Guanidines; Mesencephalon; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Phencyclidine; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Sigma Factor; Tritium | 1990 |
The lack of utility of the rat vas deferens as a functional bioassay for sigma ligands.
Topics: Animals; Binding Sites; Biological Assay; Electric Stimulation; Guanidines; Guinea Pigs; Haloperidol; Male; Muscle Contraction; Pentazocine; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Vas Deferens | 1991 |
Selective stimulation of colonic motor response to a meal by sigma ligands in dogs.
Topics: Animals; Cinnamates; Colon; Cyclopropanes; Dogs; Drug Antagonism; Eating; Gastrointestinal Motility; Guanidines; Injections, Intravenous; Injections, Intraventricular; Phenazocine; Phencyclidine; Receptors, Opioid; Receptors, sigma; Stereoisomerism | 1990 |
Opioid- and phencyclidine-like discriminative effects of ditolylguanidine, a selective sigma ligand.
Topics: Animals; Benzomorphans; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Generalization, Psychological; Guanidines; Haloperidol; Levorphanol; Male; Naltrexone; Narcotics; Phencyclidine; Rats; Receptors, Opioid; Receptors, sigma; Stereoisomerism | 1989 |
Differentiation of phencyclidine and sigma receptor types affecting the central inspiratory termination mechanism in cat.
Topics: Animals; Brain Stem; Cats; Decerebrate State; Dextrorphan; Dibenzocycloheptenes; Dizocilpine Maleate; Guanidines; Phencyclidine; Phrenic Nerve; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Respiration | 1989 |
Synthesis and evaluation of optically pure [3H]-(+)-pentazocine, a highly potent and selective radioligand for sigma receptors.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Cell Membrane; Chemical Phenomena; Chemistry; Dopamine Agents; Guanidines; Guinea Pigs; Hydroxides; Molecular Structure; Pentazocine; Phencyclidine; Piperidines; Potassium; Potassium Compounds; Receptors, Dopamine; Receptors, Opioid; Receptors, sigma; Tritium | 1989 |
Initial identification and characterization of sigma receptors on human peripheral blood leukocytes.
Topics: Animals; Guanidines; Haloperidol; Leukocytes; Lymphocyte Activation; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Schizophrenia | 1988 |
Comparison of the actions of phencyclidine and sigma ligands on CA1 hippocampal pyramidal neurons in the rat.
Topics: Action Potentials; Animals; Aspartic Acid; Guanidines; Hippocampus; Male; N-Methylaspartate; Neurons; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1988 |
Biochemical and behavioral effects of sigma and PCP ligands.
Topics: Animals; Anticonvulsants; Binding, Competitive; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Guanidines; Kinetics; Ligands; Male; Membranes; Narcotics; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Stereotyped Behavior | 1988 |
The role of NMDA and sigma systems in the behavioral effects of phencyclidine in preweanling rats.
Topics: Animals; Animals, Suckling; Anticonvulsants; Ataxia; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Guanidines; Male; Motor Activity; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1994 |
Effects of phencyclidine, MK-801 and 1,3-di(2-tolyl)guanidine on non-dopaminergic midbrain neurons.
Topics: Action Potentials; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Guanidines; Injections, Intravenous; Male; Mesencephalon; Neurons; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1993 |
Sigma receptor activation does not mediate fentanyl-induced attenuation of muscarinic coronary contraction.
Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Coronary Vessels; Cyclazocine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fentanyl; Guanidines; Haloperidol; Muscarine; Muscarinic Agonists; Narcotic Antagonists; Narcotics; Pentazocine; Phencyclidine; Piperidines; Potassium Channel Blockers; Receptors, Dopamine; Receptors, sigma; Signal Transduction; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine.
Topics: Animals; Dextromethorphan; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Guanidines; Ketamine; Ligands; Male; Phencyclidine; Piperazines; Piperidines; Protein Subunits; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 2001 |
sigma Receptor activation blocks potassium channels and depresses neuroexcitability in rat intracardiac neurons.
Topics: Action Potentials; Animals; Calcium; Dose-Response Relationship, Drug; Guanidines; Guanosine Diphosphate; Guanosine Triphosphate; Heart; Neurons; Phencyclidine; Potassium Channels; Rats; Receptors, sigma; Thionucleotides | 2005 |
Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia.
Topics: Analgesics, Opioid; Animals; Brain Ischemia; Calcium; Calcium Signaling; Cerebral Cortex; Cyclopentanes; Cytophotometry; Enzyme Inhibitors; Ethylenediamines; Female; Guanidines; Morpholines; Neurons; Pentazocine; Phencyclidine; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Sodium Azide; Sodium Channel Agonists; Tetrodotoxin | 2006 |
Afobazole modulates neuronal response to ischemia and acidosis via activation of sigma-1 receptors.
Topics: Acidosis; Animals; Anti-Anxiety Agents; Benzimidazoles; Brain Ischemia; Calcium; Cell Survival; Cerebral Cortex; Ethylenediamines; Female; Guanidines; Indicators and Reagents; L-Lactate Dehydrogenase; Membrane Potentials; Morpholines; Narcotics; Neurons; Patch-Clamp Techniques; Pentazocine; Phencyclidine; Piperazines; Pregnancy; Rats; Receptors, sigma; Sigma-1 Receptor | 2011 |