Page last updated: 2024-08-18

1,3-ditolylguanidine and pentazocine

1,3-ditolylguanidine has been researched along with pentazocine in 80 studies

Research

Studies (80)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (2.50)	18.7374
1990's	59 (73.75)	18.2507
2000's	11 (13.75)	29.6817
2010's	4 (5.00)	24.3611
2020's	4 (5.00)	2.80

Authors

Authors	Studies
de Andrés, L; Estrada Valencia, M; Herrera-Arozamena, C; Laurini, E; Morales-García, JA; Pérez, C; Pérez-Castillo, A; Pricl, S; Ramos, E; Rodríguez-Franco, MI; Romero, A; Viña, D; Yáñez, M	1
Mamolo, MG; Menegazzi, R; Romano, M; Zampieri, D	1
Börgel, F; Catapano, CV; Civenni, G; Friedland, K; Holtschulte, C; Humpf, HU; Kopp, N; Laurini, E; Lehmkuhl, K; Pricl, S; Schepmann, D; Wünsch, B	1
Kronenberg, E; Schepmann, D; Weber, F; Wünsch, B	1
Bechthold, E; Daniliuc, C; Ritter, N; Schepmann, D; Schreiber, JA; Seebohm, G; Wünsch, B	1
Amata, E; Dichiara, M; Fortuna, S; Mamolo, MG; Marrazzo, A; Pasquinucci, L; Romano, M; Turnaturi, R; Zampieri, D	1
Bowen, WD; DeCosta, B; Goldstein, SR; Hohmann, AG; Patrick, SL; Roberts, AH; Walker, JM	1
DeHaven-Hudkins, DL; Fleissner, LC	1
Chavkin, C; Connor, MA	1
Codd, EE; Shank, RP	1
Carr, DJ; DeCosta, BR; Mayo, S; Woolley, TW	1
DeHaven-Hudkins, DL; Hudkins, RL	1
Gillard, J; Knight, AR; Middlemiss, DN; Wong, EH	1
Brent, PJ	1
Connick, JH; Fox, PK; France, L; Hanlon, GM; Nicholson, CD	1
Bowen, WD; Hellewell, SB	1
Bowen, WD; Goldstein, SR; Matsumoto, RR; Patrick, RL; Thompson, TL; Walker, JM	1
Bowen, WD; de Costa, BR; Hellewell, SB; Jacobson, AE; Rice, KC; Thurkauf, A; Walker, JM	1
Brent, PJ; Dunkley, PR; Haynes, H; Jarvie, PE; Mudge, L; Sim, AT	1
DeHaven-Hudkins, DL; Hudkins, RL; Mailman, RB	1
Appleyard, SM; Chavkin, C; Connor, M; Patterson, TA	1
DeCoster, MA; Klette, KL; Knight, ES; Tortella, FC	1
Matsunaga, KH; Matsuno, K; Mita, S	1
De Costa, BR; Martin, WJ; Walker, JM	1
Hasegawa, T; Hiramatsu, M; Itoh, J; Kameyama, T; Maurice, T; Nabeshima, T	1
Hohmann, AG; Leitner, ML; Patrick, SL; Walker, JM	1
Kamei, H; Kameyama, T; Nabeshima, T	1
Barg, J; Eilam, Y; Ela, C; Hasin, Y; Vogel, Z	1
Nishikawa, T; Shirayama, Y; Takahashi, K	1
Barg, J; Belcheva, MM; Bem, WT; Ho, AM; Johnson, FE; McHale, RJ; McLachlan, JA; Parnes, MD; Thomas, GE; Tolman, KC	1
Bergeron, R; de Montigny, C; Debonnel, G; Gronier, B; Monnet, FP	1
Chaki, S; Muramatsu, M; Otomo, S; Tanaka, M	1
Basile, AS; DeCosta, B; Paul, IA	1
Ator, MA; DeHaven-Hudkins, DL; Ford-Rice, FY; Lanyon, LF	1
Basile, AS; De Costa, B; Kuijpers, GA; Paul, IA; Pollard, HB; Rojas, E; Skolnick, P; Youdim, MB	1
Lockwood, M; Patrick, RL; Patrick, SL; Perkel, JM; Walker, JM	1
Chiodo, LA; Freeman, AS; Junien, JL; Wettstein, JG; Zhang, J	1
DeHaven-Hudkins, DL; Fleissner, LC; Ford-Rice, FY; Fritz, PM; Luttinger, D	1
Kovács, KJ; Larson, AA	2
Barg, J; Eilam, Y; Ela, C; Hasin, Y; Novakova, M; Vogel, Z	1
Gudelsky, GA	2
Brum, JM; Estafanous, FG; Murray, PA; Schubert, A; Tsuchida, H	1
Barfknecht, CF; Schoenwald, RD; Shirolkar, S; Xia, E	1
Kobayashi, T; Matsuno, K; Mita, S	1
Bowen, WD; Torrence-Campbell, C	1
Bowen, WD; de Costa, BR; Monnet, FP	1
Christie, MJ; Johnston, GA; Kassiou, M; Nguyen, VH	1
Kobayashi, T; Matsuno, K; Mita, S; Tanaka, MK	1
Baine, Y; Daubert, JD; DeHaven-Hudkins, DL; Sawutz, DG; Tiberio, L	1
Ha, BK; Saini, P; Whitlock, BB; Wolfe, SA	1
Bouchard, P; Quirion, R	1
Bergeron, R; Debonnel, G	1
Bergeron, R; de Montigny, C; Debonnel, G	2
Fang, H; Helmeste, DM; Li, M; Tang, SW	1
Matsuno, K; Mita, S; Senda, T	1
Fujimura, K; In, Y; Ishida, T; Kawashima, Y; Kobayashi, T; Matsumoto, J; Niwa, M	1
Fei, YJ; Ganapathy, V; Huang, W; Leibach, FH; Li, HW; Seth, P	1
Cazin, L; Mei, YA; Roman, F; Soriani, O; Vaudry, H	1
Christie, MJ; Ingram, SL; Kassiou, M; Nguyen, VH	1
Debonnel, G; Gronier, B	1
Bucolo, C; Cacciaguerra, S; Campana, G; Di Toro, R; Spampinato, S	1
Bowen, WD; de Costa, BR; Houk, JC; Matsumoto, RR	1
Kamei, J	1
Donald, A; Kassiou, M; Mardon, K	1
Hide, I; Ichimoto, H; Inoue, A; Nakata, Y; Shoji, H; Sugita, S	1
Furukawa, S; Hiramatsu, M; Kameyama, T; Karasawa, K; Mamiya, T; Nabeshima, T; Noda, A; Noda, Y; Yamada, K	1
Ishii, D; Kawashima, K; Oka, M; Shimizu, I	2
Berardi, F; Colabufo, NA; Ferorelli, S; Leopoldo, M; Perrone, R; Tortorella, V	1
Cuevas, J; Zhang, H	1
Ishiwata, K; Kawamura, K; Kobayashi, T; Matsuno, K	1
Bowen, WD; Gebreselassie, D	1
Abate, C; Berardi, F; Colabufo, NA; Contino, M; Niso, M; Perrone, R; Tortorella, V	1
Allmon, RL; Gustafson, JL; Lever, JR; Lever, SZ; Xu, R	1
Cuevas, J; Guerrero, WR; Herrera, Y; Katnik, C; Pennypacker, KR	1
Behensky, A; Cuevas, J; Deng, W; Katnik, C	1
Abdelazeem, AH; Hiranita, T; Katz, JL; Kopajtic, TA; McCurdy, CR; Mesangeau, C; Narayanan, S; Rice, KC	1

Reviews

1 review(s) available for 1,3-ditolylguanidine and pentazocine

Article	Year
[Possible role of sigma-receptors in the regulation of cough reflex, gastrointestinal and retinal function]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1999, Volume: 114, Issue:1 Topics: Animals; Anti-Ulcer Agents; Antitussive Agents; Carbazoles; Guanidines; Haloperidol; Humans; Ligands; Pentazocine; Phenazocine; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Retinal Diseases	1999

Other Studies

79 other study(ies) available for 1,3-ditolylguanidine and pentazocine

Article	Year
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease. European journal of medicinal chemistry, 2018, Aug-05, Volume: 156 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Donepezil; Enzyme Inhibitors; Flavonoids; Humans; Indans; Lipoxygenase Inhibitors; Male; Mice, Inbred BALB C; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurogenesis; Neuroprotective Agents; Piperidines; Receptors, sigma; Sigma-1 Receptor	2018
New piperidine-based derivatives as sigma receptor ligands. Synthesis and pharmacological evaluation. Bioorganic & medicinal chemistry letters, 2018, 10-15, Volume: 28, Issue:19 Topics: Cell Line, Tumor; Humans; Ligands; Piperidines; Receptors, sigma	2018
Novel σ European journal of medicinal chemistry, 2021, Jan-15, Volume: 210 Topics: Amination; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclohexanes; Humans; Male; Mice; Prostatic Neoplasms; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship	2021
Synthesis and RSC medicinal chemistry, 2021, Mar-04, Volume: 12, Issue:2 Topics:	2021
Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil. European journal of medicinal chemistry, 2022, Jul-05, Volume: 237 Topics: Ligands; Piperidines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tropanes	2022
Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands. Bioorganic & medicinal chemistry letters, 2022, 09-15, Volume: 72 Topics: Haloperidol; Ligands; Piperidines; Quinolines; Receptors, sigma; Structure-Activity Relationship	2022
Autoradiographic distribution of [3H](+)-pentazocine and [3H]1,3-di-o-tolylguanidine (DTG) binding sites in guinea pig brain: a comparative study. Brain research, 1992, May-22, Volume: 581, Issue:1 Topics: Animals; Autoradiography; Brain Chemistry; Guanidines; Guinea Pigs; Male; Pentazocine; Receptors, Opioid; Receptors, sigma; Stereoisomerism; Tritium	1992
Competitive interactions at [3H]1,3-di(2-tolyl)guanidine (DTG)-defined sigma recognition sites in guinea pig brain. Life sciences, 1992, Volume: 50, Issue:9 Topics: Animals; Antipsychotic Agents; Binding, Competitive; Carbazoles; Dopamine Agents; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Kinetics; Male; Pentazocine; Piperidines; Radioligand Assay; Receptors, Opioid; Receptors, sigma	1992
Ionic zinc may function as an endogenous ligand for the haloperidol-sensitive sigma 2 receptor in rat brain. Molecular pharmacology, 1992, Volume: 42, Issue:3 Topics: Animals; Binding, Competitive; Brain; Cations, Divalent; Copper; Electric Stimulation; Guanidines; Haloperidol; Hippocampus; Hydrogen-Ion Concentration; Kinetics; Male; Membranes; Pentazocine; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sensitivity and Specificity; Tritium; Zinc	1992
1,3-Di(2-[5-3H]tolyl)guanidine labels more than one site in rat forebrain. European journal of pharmacology, 1992, Jul-07, Volume: 217, Issue:2-3 Topics: Animals; Binding Sites; Binding, Competitive; Carbamazepine; Guanidines; Haloperidol; Male; Pentazocine; Phenytoin; Piperidines; Prosencephalon; Rats; Rats, Wistar; Receptors, sigma; Stereoisomerism	1992
Immunoregulatory properties of (+)-pentazocine and sigma ligands. Immunology, 1992, Volume: 77, Issue:4 Topics: Animals; Cell Line; Cytotoxicity, Immunologic; Female; Guanidines; Immune Tolerance; Immunoglobulin G; Immunoglobulin M; In Vitro Techniques; Killer Cells, Natural; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Pentazocine; Pokeweed Mitogens; Receptors, sigma; Spleen	1992
Binding of dexetimide and levetimide to [3H](+)pentazocine- and [3H]1,3-di(2-tolyl)guanidine-defined sigma recognition sites. Life sciences, 1991, Volume: 49, Issue:18 Topics: Animals; Binding, Competitive; Cerebral Cortex; Dexetimide; Guanidines; Guinea Pigs; Male; Myocardium; Pentazocine; Radioligand Assay; Receptors, Muscarinic; Receptors, Opioid; Receptors, sigma	1991
The human sigma site, which resembles that in NCB20 cells, may correspond to a low-affinity site in guinea pig brain. Neuroscience letters, 1991, Oct-14, Volume: 131, Issue:2 Topics: Animals; Brain Chemistry; Cells, Cultured; Cerebral Cortex; Cricetinae; Cricetulus; Dopamine Agents; Guanidines; Guinea Pigs; Humans; Kinetics; Male; Mice; Neuroblastoma; Pentazocine; Phenazocine; Piperidines; Radioligand Assay; Receptors, Opioid; Receptors, sigma; Stereoisomerism; Tumor Cells, Cultured	1991
Similar behavioural effects of sigma agonists and PCP-like non-competitive NMDA antagonists in guinea-pigs. Psychopharmacology, 1991, Volume: 105, Issue:3 Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzamides; Dizocilpine Maleate; Dopamine Agents; Dopamine Antagonists; Ergolines; Female; Guanidines; Guinea Pigs; Haloperidol; Ketamine; Male; Motor Activity; N-Methylaspartate; Pentazocine; Phenazocine; Phencyclidine; Quinpirole; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma; Remoxipride	1991
The lack of utility of the rat vas deferens as a functional bioassay for sigma ligands. European journal of pharmacology, 1991, Feb-07, Volume: 193, Issue:2 Topics: Animals; Binding Sites; Biological Assay; Electric Stimulation; Guanidines; Guinea Pigs; Haloperidol; Male; Muscle Contraction; Pentazocine; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Vas Deferens	1991
A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain. Brain research, 1990, Sep-17, Volume: 527, Issue:2 Topics: Adrenal Gland Neoplasms; Affinity Labels; Animals; Benzomorphans; Binding, Competitive; Brain; Cell Differentiation; Cell Line; Cell Membrane; Guanidines; Guinea Pigs; Haloperidol; Kinetics; Nerve Growth Factors; Pentazocine; Pheochromocytoma; Rats; Receptors, Opioid; Receptors, sigma	1990
Motor effects of two sigma ligands mediated by nigrostriatal dopamine neurons. Synapse (New York, N.Y.), 1989, Volume: 4, Issue:3 Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Guanidines; Hydroxydopamines; Male; Oxidopamine; Pentazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Stereotyped Behavior; Substantia Nigra	1989
Synthesis and evaluation of optically pure [3H]-(+)-pentazocine, a highly potent and selective radioligand for sigma receptors. FEBS letters, 1989, Jul-17, Volume: 251, Issue:1-2 Topics: Animals; Apomorphine; Binding, Competitive; Brain; Cell Membrane; Chemical Phenomena; Chemistry; Dopamine Agents; Guanidines; Guinea Pigs; Hydroxides; Molecular Structure; Pentazocine; Phencyclidine; Piperidines; Potassium; Potassium Compounds; Receptors, Dopamine; Receptors, Opioid; Receptors, sigma; Tritium	1989
Phosphorylation of synapsin I and dynamin in rat forebrain synaptosomes: modulation by sigma (sigma) ligands. Neuroscience letters, 1995, May-19, Volume: 191, Issue:1-2 Topics: Animals; Anticonvulsants; Dynamins; GTP Phosphohydrolases; Guanidines; Haloperidol; In Vitro Techniques; Microtubules; Pentazocine; Phenazocine; Phosphorylation; Prosencephalon; Rats; Receptors, sigma; Synapsins; Synaptosomes	1995
RLH-033, a novel, potent and selective ligand for the sigma 1 recognition site. European journal of pharmacology, 1994, Dec-12, Volume: 271, Issue:1 Topics: Animals; Anticonvulsants; Cyclopentanes; Guanidines; Guinea Pigs; In Vitro Techniques; Ligands; Pentazocine; Piperidines; Radioligand Assay; Receptors, sigma	1994
Oocytes from Xenopus laevis contain an intrinsic sigma 2-like binding site. Neuroscience letters, 1994, Oct-24, Volume: 180, Issue:2 Topics: Animals; Binding Sites; Binding, Competitive; Carbazoles; Dextromethorphan; Female; Guanidines; Haloperidol; Liver; Mazindol; Oocytes; Pentazocine; Phenazocine; Piperazines; Piperidines; Radioligand Assay; Rats; Receptors, sigma; Xenopus laevis; Zinc	1994
Sigma receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures. Brain research, 1995, Feb-06, Volume: 671, Issue:1 Topics: Animals; Calcium; Cells, Cultured; Cyclazocine; Cyclopentanes; Dextromethorphan; Glutamic Acid; Guanidines; Haloperidol; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Pentazocine; Phenazocine; Piperidines; Rats; Receptors, sigma	1995
Acute effects of sigma ligands on the extracellular DOPAC level in rat frontal cortex and striatum. Neurochemical research, 1995, Volume: 20, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anticonvulsants; Antipsychotic Agents; Carbazoles; Corpus Striatum; Extracellular Space; Frontal Lobe; Guanidines; Kinetics; Ligands; Male; Microdialysis; Pentazocine; Phenazocine; Piperidines; Rats; Rats, Wistar; Receptors, sigma; Time Factors	1995
Effects of sigma ligands on rat cerebellar Purkinje neuron firing: an iontophoretic study. Brain research bulletin, 1994, Volume: 35, Issue:4 Topics: Animals; Ethylamines; Guanidines; Iontophoresis; Levallorphan; Male; Pentazocine; Piperidines; Purkinje Cells; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, sigma	1994
Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice. Psychopharmacology, 1994, Volume: 114, Issue:3 Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Guanidines; Male; Memory; Mice; Mice, Inbred Strains; Motor Activity; Pentazocine; Phenazocine; Pyrimidines; Receptors, sigma; Space Perception	1994
Regional variation in the ratio of sigma 1 to sigma 2 binding in rat brain. European journal of pharmacology, 1994, Jun-23, Volume: 259, Issue:1 Topics: Animals; Binding Sites; Brain; Brain Chemistry; Guanidines; Male; Pentazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma	1994
SKF-10,047 reverses stress-induced motor suppression: interaction with dopaminergic system. European journal of pharmacology, 1994, Jul-21, Volume: 260, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anticonvulsants; Apomorphine; Dopamine; Electroshock; Guanidines; Male; Methamphetamine; Mice; Mice, Inbred Strains; Motor Activity; Oxidopamine; Pentazocine; Phenazocine; Pimozide; Pyrimidines; Receptors, sigma; Stress, Psychological	1994
Sigma receptor ligands modulate contractility, Ca++ influx and beating rate in cultured cardiac myocytes. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:3 Topics: Animals; Calcium; Cells, Cultured; GTP-Binding Proteins; Guanidines; Haloperidol; Heart Rate; Myocardial Contraction; Pentazocine; Piperidines; Rats; Receptors, sigma; Sarcoplasmic Reticulum	1994
Differential effects of repeated dl-pentazocine treatment on sigma binding sites in discrete brain areas of the rat. Neuroscience letters, 1994, Jan-03, Volume: 165, Issue:1-2 Topics: Animals; Anticonvulsants; Brain Chemistry; Dextroamphetamine; Guanidines; Haloperidol; Kinetics; Male; Methamphetamine; Pentazocine; Rats; Rats, Wistar; Receptors, sigma; Stereoisomerism	1994
In vitro and in vivo expression of opioid and sigma receptors in rat C6 glioma and mouse N18TG2 neuroblastoma cells. Journal of neurochemistry, 1994, Volume: 63, Issue:2 Topics: Animals; Binding, Competitive; Cell Line; Cell Membrane; Convulsants; Enkephalin, Leucine-2-Alanine; Glioma; Guanidines; Kinetics; Male; Mice; Mice, Nude; Neuroblastoma; Pentazocine; Rats; Receptors, Opioid; Receptors, sigma; Transplantation, Heterologous; Tumor Cells, Cultured	1994
The effects of sigma ligands and of neuropeptide Y on N-methyl-D-aspartate-induced neuronal activation of CA3 dorsal hippocampus neurones are differentially affected by pertussin toxin. British journal of pharmacology, 1994, Volume: 112, Issue:2 Topics: Animals; Anticonvulsants; Cinnamates; Cyclopropanes; Drug Synergism; GTP-Binding Proteins; Guanidines; Haloperidol; Hippocampus; Ligands; Male; N-Methylaspartate; Neurons; Neuropeptide Y; Pentazocine; Pertussis Toxin; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, sigma; Virulence Factors, Bordetella	1994
NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain. European journal of pharmacology, 1994, Jan-04, Volume: 251, Issue:1 Topics: Animals; Anisoles; Binding, Competitive; Brain; Guanidines; Guinea Pigs; In Vitro Techniques; Ligands; Pentazocine; Propylamines; Receptors, sigma	1994
Multiple [3H]DTG binding sites in guinea pig cerebellum: evidence for the presence of non-specific binding. European journal of pharmacology, 1994, Feb-03, Volume: 252, Issue:2 Topics: Animals; Anticonvulsants; Binding, Competitive; Cerebellum; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Levallorphan; Liver; Male; Membranes; Models, Biological; Pentazocine; Receptors, sigma	1994
sigma recognition sites in brain and peripheral tissues. Characterization and effects of cytochrome P450 inhibitors. Biochemical pharmacology, 1994, Mar-29, Volume: 47, Issue:7 Topics: Animals; Binding Sites; Brain; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Guanidines; Guinea Pigs; Heart; Isoenzymes; Liver; Male; Pentazocine; Rats; Subcellular Fractions; Testis	1994
Sigma receptors modulate nicotinic receptor function in adrenal chromaffin cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1993, Volume: 7, Issue:12 Topics: Adrenal Medulla; Animals; Calcium; Catecholamines; Cattle; Cells, Cultured; Guanidines; Nicotine; Pentazocine; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Receptors, sigma	1993
Increases in rat striatal extracellular dopamine and vacuous chewing produced by two sigma receptor ligands. European journal of pharmacology, 1993, Feb-09, Volume: 231, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dialysis; Dopamine; Extracellular Space; Guanidines; Homovanillic Acid; Male; Pentazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stereotyped Behavior	1993
Repeated administration of Sigma ligands alters the population activity of rat midbrain dopaminergic neurons. Synapse (New York, N.Y.), 1993, Volume: 13, Issue:3 Topics: Animals; Cinnamates; Cyclopropanes; Dopamine; Guanidines; Ligands; Male; Mesencephalon; Neurons; Pentazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma; Time Factors	1993
Sigma receptor binding affinity and inhibition of apomorphine-induced climbing. European journal of pharmacology, 1993, Apr-28, Volume: 235, Issue:2-3 Topics: Animals; Apomorphine; Behavior, Animal; Dose-Response Relationship, Drug; Guanidines; Male; Mice; Pentazocine; Radioligand Assay; Receptors, sigma	1993
Discrepancies in characterization of sigma sites in the mouse central nervous system. European journal of pharmacology, 1995, Oct-16, Volume: 285, Issue:2 Topics: Animals; Brain Chemistry; Central Nervous System; Cerebellum; Cerebral Cortex; Guanidines; In Vitro Techniques; Ligands; Male; Membranes; Mice; Narcotics; Pentazocine; Radioligand Assay; Receptors, sigma; Spinal Cord	1995
Inotropic action of sigma receptor ligands in isolated cardiac myocytes from adult rats. European journal of pharmacology, 1995, Nov-03, Volume: 286, Issue:1 Topics: Animals; Binding Sites; Calcium; Guanidines; In Vitro Techniques; Ligands; Myocardial Contraction; Myocardium; Pentazocine; Piperidines; Rats; Receptors, sigma; Stimulation, Chemical	1995
Effects of sigma receptor ligands on the extracellular concentration of dopamine in the striatum and prefrontal cortex of the rat. European journal of pharmacology, 1995, Nov-24, Volume: 286, Issue:3 Topics: Animals; Benzomorphans; Corpus Striatum; Dopamine; Guanidines; Ligands; Male; Pentazocine; Piperazines; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stereoisomerism	1995
Sigma receptor activation does not mediate fentanyl-induced attenuation of muscarinic coronary contraction. Anesthesia and analgesia, 1996, Volume: 82, Issue:5 Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Coronary Vessels; Cyclazocine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fentanyl; Guanidines; Haloperidol; Muscarine; Muscarinic Agonists; Narcotic Antagonists; Narcotics; Pentazocine; Phencyclidine; Piperidines; Potassium Channel Blockers; Receptors, Dopamine; Receptors, sigma; Signal Transduction; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents	1996
The effects of sigma ligands on protein release from lacrimal acinar cells: a potential agonist/antagonist assay. Life sciences, 1995, Mar-03, Volume: 56, Issue:15 Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Eye Proteins; Guanidines; Haloperidol; In Vitro Techniques; Lacrimal Apparatus; Pentazocine; Phenethylamines; Pyrimidines; Rabbits; Receptors, sigma	1995
Involvement of sigma-receptors in the increase in contraction of mouse vas deferens induced by exogenous ATP. The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:1 Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Anticonvulsants; Antipsychotic Agents; Carbazoles; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Guanidines; Haloperidol; Ligands; Male; Mice; Muscle Contraction; Muscle, Smooth; Pentazocine; Phenazocine; Piperidines; Receptors, sigma; Regression Analysis; Structure-Activity Relationship; Vas Deferens	1996
Differential solubilization of rat liver sigma 1 and sigma 2 receptors: retention of sigma 2 sites in particulate fractions. European journal of pharmacology, 1996, May-23, Volume: 304, Issue:1-3 Topics: Animals; Binding, Competitive; Cell Fractionation; Cell Membrane; Cholic Acids; Detergents; Guanidines; Haloperidol; In Vitro Techniques; Liver; Male; Pentazocine; Phenazocine; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Solubility; Subcellular Fractions	1996
Differentiation of sigma ligand-activated receptor subtypes that modulate NMDA-evoked [3H]-noradrenaline release in rat hippocampal slices. British journal of pharmacology, 1996, Volume: 119, Issue:1 Topics: Animals; Anisoles; Anticonvulsants; Antipsychotic Agents; Cyclohexylamines; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Ligands; Male; N-Methylaspartate; Narcotics; Norepinephrine; Pentazocine; Propylamines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Tritium	1996
Comparison of binding parameters of sigma 1 and sigma 2 binding sites in rat and guinea pig brain membranes: novel subtype-selective trishomocubanes. European journal of pharmacology, 1996, Sep-12, Volume: 311, Issue:2-3 Topics: Analgesics, Opioid; Animals; Anticonvulsants; Binding Sites; Binding, Competitive; Brain; Bridged-Ring Compounds; Female; Guanidines; Guinea Pigs; Male; Membranes; Pentazocine; Rats; Receptors, sigma; Structure-Activity Relationship	1996
Sigma 1 receptor subtype is involved in the relief of behavioral despair in the mouse forced swimming test. European journal of pharmacology, 1996, Oct-03, Volume: 312, Issue:3 Topics: Animals; Anisoles; Cinnamates; Cyclopropanes; Guanidines; Male; Mice; Mice, Inbred Strains; Motor Activity; Pentazocine; Piperazines; Propylamines; Receptors, sigma; Stress, Physiological	1996
[3H]1,3-di(2-tolyl) guanidine binds to a sigma 2 receptor on Jurkat cell membranes, but sigma compounds fail to influence immunomodulatory events in human peripheral blood lymphocytes. Immunopharmacology, 1996, Volume: 35, Issue:1 Topics: Binding, Competitive; Cell Membrane; Guanidines; Haloperidol; Humans; Interleukin-2; Jurkat Cells; Lymphocyte Activation; Narcotics; Pentazocine; Protein Binding; Receptors, sigma; T-Lymphocytes	1996
Differential localization of three distinct binding sites for sigma receptor ligands in rat spleen. Journal of neuroimmunology, 1997, Volume: 72, Issue:1 Topics: Analgesics, Opioid; Animals; Anticonvulsants; Antipsychotic Agents; Autoradiography; Binding Sites; Dopamine Agonists; Dopamine Antagonists; Female; Guanidines; Haloperidol; Image Processing, Computer-Assisted; Ligands; Male; Naltrexone; Narcotic Antagonists; Pentazocine; Phenazocine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Spleen; Tritium	1997
[3H]1,3-di(2-tolyl)guanidine and [3H](+)pentazocine binding sites in the rat brain: autoradiographic visualization of the putative sigma1 and sigma2 receptor subtypes. Neuroscience, 1997, Volume: 76, Issue:2 Topics: Analgesics, Opioid; Animals; Anticonvulsants; Autoradiography; Brain; Brain Chemistry; Guanidines; Locomotion; Male; Pentazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma	1997
Effects of low and high doses of selective sigma ligands: further evidence suggesting the existence of different subtypes of sigma receptors. Psychopharmacology, 1997, Volume: 129, Issue:3 Topics: Animals; Cinnamates; Cyclohexylamines; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Excitatory Amino Acid Agonists; Guanidines; Hippocampus; Ligands; Male; N-Methylaspartate; Neurons; Pentazocine; Piperidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, sigma	1997
Effect of short-term and long-term treatments with sigma ligands on the N-methyl-D-aspartate response in the CA3 region of the rat dorsal hippocampus. British journal of pharmacology, 1997, Volume: 120, Issue:7 Topics: Animals; Cinnamates; Cyclopropanes; Guanidines; Haloperidol; Hippocampus; Male; N-Methylaspartate; Pentazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma	1997
Multiple [3H]-nemonapride binding sites in calf brain. Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Benzamides; Binding, Competitive; Brain; Cattle; Cerebellum; Cerebral Cortex; Corpus Striatum; Dioxanes; Dopamine Agonists; Dopamine Antagonists; Guanidines; Haloperidol; In Vitro Techniques; Isotope Labeling; Narcotic Antagonists; Pentazocine; Piperidines; Propylamines; Pyrrolidines; Receptors, Dopamine D2; Receptors, sigma; Sulpiride; Tritium	1997
The presence of sigma receptor subtypes in bovine retinal membranes. Experimental eye research, 1997, Volume: 64, Issue:5 Topics: Animals; Binding, Competitive; Cattle; Guanidines; Ligands; Pentazocine; Receptors, sigma; Retina	1997
Synthesis, structure and quantitative structure-activity relationships of sigma receptor ligands, 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl) piperazines. Bioorganic & medicinal chemistry, 1997, Volume: 5, Issue:8 Topics: Analgesics, Opioid; Anticonvulsants; Crystallography, X-Ray; Guanidines; Ligands; Molecular Weight; Pentazocine; Piperazines; Receptors, sigma; Structure-Activity Relationship	1997
Cloning and functional characterization of a sigma receptor from rat brain. Journal of neurochemistry, 1998, Volume: 70, Issue:3 Topics: Amino Acid Sequence; Animals; Anticonvulsants; Antidepressive Agents; Base Sequence; Binding, Competitive; Brain Chemistry; Choriocarcinoma; Cloning, Molecular; Clorgyline; DNA, Complementary; Dopamine Antagonists; Gene Expression; Gene Library; Guanidines; Haloperidol; HeLa Cells; Humans; Kinetics; Liver; Molecular Sequence Data; Narcotics; Pentazocine; Phenytoin; Placenta; Rats; Receptors, sigma; RNA, Messenger; Steroids	1998
Sigma ligands stimulate the electrical activity of frog pituitary melanotrope cells through a G-protein-dependent inhibition of potassium conductances. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1 Topics: Action Potentials; Animals; Cells, Cultured; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanidines; Male; Pentazocine; Pituitary Gland; Potassium Channel Blockers; Rana ridibunda; Receptors, sigma	1998
Up-regulation of [3H]DTG but not [3H](+)-pentazocine labeled sigma sites in mouse spinal cord by chronic morphine treatment. European journal of pharmacology, 1998, May-29, Volume: 350, Issue:1 Topics: Analysis of Variance; Animals; Cerebral Cortex; Drug Tolerance; Guanidines; Male; Mice; Morphine; Morphine Dependence; Narcotics; Pentazocine; Receptors, sigma; Spinal Cord	1998
Sigma-binding site ligands inhibit K+ currents in rat locus coeruleus neurons in vitro. European journal of pharmacology, 1998, Nov-13, Volume: 361, Issue:1 Topics: Action Potentials; Animals; Anticonvulsants; Binding Sites; Binding, Competitive; Cell Membrane; Dextromethorphan; Dopamine Antagonists; Enkephalin, Methionine; Excitatory Amino Acid Antagonists; Guanidines; Haloperidol; In Vitro Techniques; Ligands; Locus Coeruleus; Male; Narcotics; Neurons; Pentazocine; Potassium Channels; Rats; Rats, Sprague-Dawley	1998
Involvement of sigma receptors in the modulation of the glutamatergic/NMDA neurotransmission in the dopaminergic systems. European journal of pharmacology, 1999, Mar-05, Volume: 368, Issue:2-3 Topics: Analgesics, Opioid; Animals; Caudate Nucleus; Cinnamates; Cyclopropanes; Dopamine; Electrophysiology; Excitatory Amino Acids; Glutamic Acid; Guanidines; Kainic Acid; Male; N-Methylaspartate; Neurons; Nucleus Accumbens; Pentazocine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, sigma; Sigma-1 Receptor; Spiro Compounds; Substantia Nigra; Synaptic Transmission; Thiazoles; Ventral Tegmental Area	1999
Sigma1 recognition sites in rabbit iris-ciliary body: topical sigma1-site agonists lower intraocular pressure. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:3 Topics: Animals; Anisoles; Antipsychotic Agents; Binding, Competitive; Cell Membrane; Ciliary Body; Functional Laterality; Guanidines; Intraocular Pressure; Iris; Kinetics; Lens, Crystalline; Male; Pentazocine; Phenazocine; Propylamines; Rabbits; Receptors, sigma; Retina; Tritium	1999
Relationship between modulation of the cerebellorubrospinal system in the in vitro turtle brain and changes in motor behavior in rats: effects of novel sigma ligands. Brain research bulletin, 1999, Mar-15, Volume: 48, Issue:5 Topics: Animals; Anticonvulsants; Binding, Competitive; Dystonia; Ethylenediamines; Evoked Potentials, Motor; Guanidines; Ligands; Male; Motor Neurons; Narcotic Antagonists; Pentazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma; Red Nucleus; Species Specificity; Turtles	1999
Pregnancy reduces brain sigma receptor function. British journal of pharmacology, 1999, Volume: 127, Issue:8 Topics: Action Potentials; Adjuvants, Immunologic; Analgesics, Opioid; Animals; Anticonvulsants; Dehydroepiandrosterone; Female; Guanidines; Hippocampus; Ovariectomy; Pentazocine; Postpartum Period; Pregnancy; Progesterone; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma	1999
Biphasic effect of sigma receptor ligands on the extracellular concentration of dopamine in the striatum of the rat. Journal of neural transmission (Vienna, Austria : 1996), 1999, Volume: 106, Issue:9-10 Topics: Analgesics, Opioid; Animals; Anticonvulsants; Corpus Striatum; Dopamine; Excitatory Amino Acid Antagonists; Guanidines; Ligands; Male; Microdialysis; Pentazocine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, sigma	1999
Effects of streptozotocin-induced diabetes on neuronal sigma receptors in the rat brain. Life sciences, 1999, Oct-29, Volume: 65, Issue:23 Topics: Analgesics, Opioid; Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental; Glycosuria; Guanidines; Haloperidol; Kinetics; Male; Pentazocine; Rats; Rats, Wistar; Receptors, sigma	1999
Repeated haloperidol treatment decreases sigma(1) receptor binding but does not affect its mRNA levels in the guinea pig or rat brain. European journal of pharmacology, 2000, Aug-11, Volume: 401, Issue:3 Topics: Animals; Antipsychotic Agents; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Haloperidol; Male; Pentazocine; Radioligand Assay; Rats; Rats, Wistar; Receptors, sigma; RNA, Messenger; Tritium	2000
Effects of sigma receptor agonists on the impairment of spontaneous alternation behavior and decrease of cyclic GMP level induced by nitric oxide synthase inhibitors in mice. Neuropharmacology, 2000, Volume: 39, Issue:12 Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Behavior, Animal; Brain Chemistry; Cyclic GMP; Enzyme Inhibitors; Guanidines; Indazoles; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pentazocine; Phenazocine; Pyrimidines; Receptors, sigma	2000
Effects of (+)-pentazocine and 1,3-di-o-tolylguanidine (DTG), sigma (sigma) ligands, on micturition in anaesthetized rats. British journal of pharmacology, 2000, Volume: 131, Issue:3 Topics: Anesthesia; Animals; Anticonvulsants; Electric Stimulation; Guanidines; Ligands; Male; Muscle Contraction; Narcotic Antagonists; Pentazocine; Pertussis Toxin; Rats; Rats, Wistar; Receptors, sigma; Syncope; Urinary Bladder; Virulence Factors, Bordetella	2000
A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites. Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:5 Topics: Animals; Binding Sites; Brain; Calcium Channels, L-Type; Carrier Proteins; Dizocilpine Maleate; Guanidines; Guinea Pigs; In Vitro Techniques; Inhibitory Concentration 50; Ligands; Liver; Pentazocine; Piperidines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Structure-Activity Relationship	2001
Effects of AH-9700, (+)-pentazocine, DTG and oxybutynin on micturition in anesthetized rats with acetone-induced cystitis. Life sciences, 2001, Aug-24, Volume: 69, Issue:14 Topics: Acetone; Anesthesia; Animals; Cystitis; Disease Models, Animal; Fumarates; Guanidines; Male; Mandelic Acids; Naphthalenes; Pentazocine; Rats; Rats, Wistar; Urination	2001
Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons. Journal of neurophysiology, 2002, Volume: 87, Issue:6 Topics: Analgesics, Opioid; Animals; Anticonvulsants; Calcium; Calcium Channels; Cells, Cultured; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Ganglia, Parasympathetic; Gene Expression; Guanidines; Guanosine Diphosphate; Guanosine Triphosphate; Haloperidol; Ibogaine; Ion Channel Gating; Membrane Potentials; Microdialysis; Neurons; Pentazocine; Rats; Receptors, sigma; RNA, Messenger; Signal Transduction; Superior Cervical Ganglion; Thionucleotides	2002
Age-related changes of the binding of [3h]SA4503 to sigma1 receptors in the rat brain. Annals of nuclear medicine, 2003, Volume: 17, Issue:1 Topics: Aging; Animals; Brain; Carbon Radioisotopes; Cell Membrane; Dose-Response Relationship, Drug; Guanidines; In Vitro Techniques; Male; Pentazocine; Piperazines; Protein Binding; Radiopharmaceuticals; Rats; Rats, Inbred F344; Receptors, sigma; Sexual Abstinence; Sigma-1 Receptor	2003
Sigma-2 receptors are specifically localized to lipid rafts in rat liver membranes. European journal of pharmacology, 2004, Jun-16, Volume: 493, Issue:1-3 Topics: Animals; Cell Membrane; Cholic Acids; Endothelial Cells; Guanidines; Humans; Immunoblotting; Levallorphan; Liver; Liver Extracts; Male; Membrane Microdomains; Membrane Proteins; National Institutes of Health (U.S.); Nerve Tissue Proteins; Octoxynol; Pentazocine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor; Tritium; United States	2004
Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines. Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 370, Issue:2 Topics: Animals; Anisoles; Antineoplastic Agents; Binding, Competitive; Brain; Cell Line, Tumor; Guanidines; Guinea Pigs; Haloperidol; Humans; In Vitro Techniques; Ligands; Liver; Membranes; Pentazocine; Piperazines; Propylamines; Pyridines; Radioligand Assay; Rats; Receptors, sigma; Sigma-1 Receptor	2004
Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse (New York, N.Y.), 2006, Volume: 59, Issue:6 Topics: Animals; Autoradiography; Binding, Competitive; Brain; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluorine Radioisotopes; Guanidines; Guinea Pigs; Haloperidol; Inhibitory Concentration 50; Ligands; Male; Narcotic Antagonists; Pentazocine; Piperazines; Protein Binding; Radioligand Assay; Radiopharmaceuticals; Receptors, sigma; Structure-Activity Relationship	2006
Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:3 Topics: Analgesics, Opioid; Animals; Brain Ischemia; Calcium; Calcium Signaling; Cerebral Cortex; Cyclopentanes; Cytophotometry; Enzyme Inhibitors; Ethylenediamines; Female; Guanidines; Morpholines; Neurons; Pentazocine; Phencyclidine; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Sodium Azide; Sodium Channel Agonists; Tetrodotoxin	2006
Afobazole modulates neuronal response to ischemia and acidosis via activation of sigma-1 receptors. The Journal of pharmacology and experimental therapeutics, 2011, Volume: 339, Issue:1 Topics: Acidosis; Animals; Anti-Anxiety Agents; Benzimidazoles; Brain Ischemia; Calcium; Cell Survival; Cerebral Cortex; Ethylenediamines; Female; Guanidines; Indicators and Reagents; L-Lactate Dehydrogenase; Membrane Potentials; Morpholines; Narcotics; Neurons; Patch-Clamp Techniques; Pentazocine; Phencyclidine; Piperazines; Pregnancy; Rats; Receptors, sigma; Sigma-1 Receptor	2011
Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists. The Journal of pharmacology and experimental therapeutics, 2016, Volume: 358, Issue:1 Topics: Animals; Behavior, Animal; Brain; Cocaine; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; In Vitro Techniques; Ligands; Male; Morpholines; Pentazocine; Protein Binding; Radioligand Assay; Rats, Sprague-Dawley; Receptors, sigma; Self Administration	2016