1,3-ditolylguanidine has been researched along with ifenprodil in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Berardi, F; Colabufo, NA; Fracchiolla, G; Loiodice, F; Perrone, R; Tortorella, V | 1 |
| Abate, C; Berardi, F; Colabufo, NA; Contino, M; Ferorelli, S; Pedone, MP; Perrone, R | 2 |
| Abate, C; Berardi, F; Colabufo, NA; Ferorelli, S; Inglese, C; Niso, M; Perrone, R | 1 |
| Abate, C; Berardi, F; Colabufo, NA; de Robertis, AF; Ferorelli, S; Leopoldo, M; Niso, M; Perrone, R | 1 |
| Fermeglia, M; Florio, C; Laurini, E; Mamolo, MG; Paneni, MS; Posocco, P; Pricl, S; Vio, L; Zampieri, D; Zanette, C | 1 |
| Abate, C; Berardi, F; Colabufo, NA; Ferorelli, S; Niso, M; Perrone, R; Uricchio, V | 1 |
| Frehland, B; Schepmann, D; Schmidtke, KU; Tewes, B; Winckler, T; Wünsch, B | 1 |
| Bonifazi, A; Gawaskar, S; Schepmann, D; Wünsch, B | 1 |
| Dey, S; Frehland, B; Lehmkuhl, K; Schepmann, D; Schreiber, JA; Seebohm, G; Strutz-Seebohm, N; Temme, L; Wünsch, B | 1 |
| Dey, S; Schepmann, D; Wünsch, B | 1 |
| Kitamura, M; Schepmann, D; Shuto, Y; Temme, L; Thum, S; Wünsch, B | 1 |
| Baumeister, S; Schepmann, D; Wünsch, B | 1 |
| Calabretti, A; Fortuna, S; Mamolo, MG; Menegazzi, R; Romano, M; Schepmann, D; Wünsch, B; Zampieri, D | 1 |
| Hashimoto, K; London, ED; Mantione, CR; Neumeyer, JL; Spada, MR | 1 |
| Aoki, K; Narita, M; Nomura, M; Suzuki, T; Yoshizawa, K | 1 |
16 other study(ies) available for 1,3-ditolylguanidine and ifenprodil
| Article | Year |
|---|---|
Synthesis of chiral 1-[omega-(4-chlorophenoxy)alkyl]-4-methylpiperidines and their biological evaluation at sigma1, sigma2, and sterol delta8-delta7 isomerase sites.
Topics: Animals; Binding Sites; Guinea Pigs; Ligands; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, sigma; Stereoisomerism; Steroid Isomerases; Structure-Activity Relationship | 2003 |
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma(1) receptor.
Topics: Animals; Cell Proliferation; Methylation; Naphthalenes; Piperidines; Radioligand Assay; Rats; Receptors, sigma; Steroid Isomerases; Structure-Activity Relationship; Tumor Cells, Cultured | 2005 |
Design and evaluation of naphthol- and carbazole-containing fluorescent sigma ligands as potential probes for receptor binding studies.
Topics: Animals; Carbazoles; Competitive Bidding; Fluorescent Dyes; In Vitro Techniques; Ligands; Liver; Naphthols; Piperazines; Piperidines; Radioligand Assay; Rats; Receptors, Opioid, delta; Structure-Activity Relationship | 2007 |
Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity.
Topics: Apoptosis; Binding Sites; Cell Proliferation; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Ligands; Models, Molecular; Molecular Structure; Piperazines; Pyridines; Stereoisomerism; Steroid Isomerases; Structure-Activity Relationship; Tumor Cells, Cultured | 2008 |
Synthesis, biological evaluation, and three-dimensional in silico pharmacophore model for sigma(1) receptor ligands based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives.
Topics: Animals; Benzene; Computational Biology; Ligands; Models, Molecular; Molecular Conformation; Oxazoles; Rats; Receptors, sigma; Sigma-1 Receptor | 2009 |
Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).
Topics: Amides; Animals; Cell Line, Tumor; Cell Proliferation; Guinea Pigs; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Male; Naphthalenes; Nitrogen; Piperazines; Rats; Receptors, sigma; Steroid Isomerases; Structure-Activity Relationship | 2009 |
Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols.
Topics: Analgesics; Animals; Benzazepines; Humans; Mice; Microsomes, Liver; Neuralgia; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2010 |
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ₁ receptor ligands.
Topics: Animals; Binding Sites; Guinea Pigs; Ligands; Piperidines; Protein Binding; Radioligand Assay; Rats; Receptors, sigma; Steroid Isomerases; Structure-Activity Relationship | 2011 |
Synthesis, GluN2B affinity and selectivity of benzo[7]annulen-7-amines.
Topics: Benzocycloheptenes; Dose-Response Relationship, Drug; Humans; Molecular Structure; Piperazines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2014 |
Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors.
Topics: Benzazepines; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2017 |
2-Methyltetrahydro-3-benzazepin-1-ols - The missing link in SAR of GluN2B selective NMDA receptor antagonists.
Topics: Benzazepines; Dose-Response Relationship, Drug; Humans; Molecular Docking Simulation; Molecular Structure; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2018 |
Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain?
Topics: | 2017 |
Thiophene bioisosteres of GluN2B selective NMDA receptor antagonists: Synthesis and pharmacological evaluation of [7]annuleno[b]thiophen-6-amines.
Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; Molecular Structure; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Thiophenes | 2020 |
Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands.
Topics: | 2020 |
Further characterization of [3H]ifenprodil binding in rat brain.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brain; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Guanidines; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Piperazines; Piperidines; Rats; Rats, Inbred F344; Receptors, sigma | 1994 |
Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine.
Topics: Animals; Dextromethorphan; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Guanidines; Ketamine; Ligands; Male; Phencyclidine; Piperazines; Piperidines; Protein Subunits; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 2001 |