Page last updated: 2024-08-18

1,3-ditolylguanidine and haloperidol

1,3-ditolylguanidine has been researched along with haloperidol in 147 studies

Research

Studies (147)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (3.40)	18.7374
1990's	77 (52.38)	18.2507
2000's	27 (18.37)	29.6817
2010's	32 (21.77)	24.3611
2020's	6 (4.08)	2.80

Authors

Authors	Studies
Bowen, W; de Costa, BR; Dominguez, C; He, XS; Radesca, L; Williams, W	1
Campbell, BG; Kimes, AS; London, ED; Scheffel, U; Wilson, AA	1
el-Ashmawy, M; Fischer, JB; Glennon, RA; Herndon, JL; Howie, KJ; Ismaiel, AM; Server, AC; Smith, JD; Yousif, M	1
Dannals, RF; Ravert, HT; Sonders, MS; Wagner, HN; Weber, E; Wilson, AA	1
Meier, E; Moltzen, EK; Perregaard, J; Sánchez, C	1
Meier, E; Moltzen, EK; Perregaard, J	1
Bowen, WD; John, CS; Vilner, BJ	1
DeHaven-Hudkins, DL; Hudkins, RL; Mailman, RB	1
Bowen, WD; Cutts, J; de Costa, BR; Dominguez, C; He, XS; Williams, W	1
Bowen, WD; de Costa, BR; Dominguez, C; Gu, ZQ; He, XS; Linders, JT; Williams, W	1
Berardi, F; Colabufo, NA; Giudice, G; Govoni, S; Lucchi, L; Perrone, R; Tortorella, V	1
Maier, CA; Wünsch, B	1
Brasili, L; Costantino, L; Franchini, S; Gandolfi, F; Leonardi, A; Poggesi, E; Prezzavento, O; Ronsisvalle, G; Sorbi, C; Vittorio, F	1
Fiechtner, B; Glossmann, H; Hoffmann, RD; Laggner, C; Langer, T; Moebius, FF; Poles, G; Schieferer, C	1
Bramanti, V; Cagnotto, A; Campisi, A; Cannavò, G; Ientile, R; Li Volti, G; Marrazzo, A; Mennini, T; Prezzavento, O; Ronsisvalle, G; Ronsisvalle, S; Vanella, L	1
Weigl, M; Wünsch, B	1
Abate, C; Berardi, F; Colabufo, NA; Contino, M; Ferorelli, S; Inglese, C; Perrone, R	1
Schepmann, D; Schläger, T; Wünsch, B; Würthwein, EU	1
Azzolina, O; Collina, S; Florio, C; Grazia Mamolo, M; Laurini, E; Rossi, D; Vio, L; Zampieri, D; Zanette, C	1
Bedürftig, S; Wünsch, B	1
Diaz, JL; Holenz, J; Oberdorf, C; Schepmann, D; Vela, JM; Wünsch, B	1
Bednarski, PJ; Grünert, R; Holl, R; Schepmann, D; Wünsch, B	2
Bednarski, PJ; Fröhlich, R; Grünert, R; Holl, R; Schepmann, D; Wünsch, B	1
Brust, P; Fischer, S; Grosse Maestrup, E; Hiller, A; Schepmann, D; Scheunemann, M; Wiese, C; Wünsch, B	1
Fermeglia, M; Florio, C; Laurini, E; Mamolo, MG; Paneni, MS; Posocco, P; Pricl, S; Vio, L; Zampieri, D; Zanette, C	1
Buschmann, H; Holenz, J; Jasper, A; Lehmkuhl, K; Schepmann, D; Vela, JM; Wünsch, B	2
Brust, P; Deuther-Conrad, W; Fischer, S; Hiller, A; Maestrup, EG; Schepmann, D; Steinbach, J; Wiese, C; Wünsch, B	1
Englberger, W; Geiger, C; Lehmkuhl, K; Schepmann, D; Wünsch, B; Zelenka, C	1
Frehland, B; Schepmann, D; Schmidtke, KU; Tewes, B; Winckler, T; Wünsch, B	1
Aricò, G; Cobos, EJ; Colabufo, NA; Contino, M; González, LG; Marrazzo, A; Marrazzo, G; Parenti, C; Pasquinucci, L; Prezzavento, O; Ronsisvalle, G; Ronsisvalle, S; Scoto, GM	1
Buschmann, H; Holenz, J; Lehmkuhl, K; Schepmann, D; Schläger, T; Vela, JM; Wünsch, B	1
Buschmann, H; Holenz, J; Oberdorf, C; Schepmann, D; Vela, JM; Wünsch, B	1
Kitamura, Y; Kozaka, T; Miwa, D; Ogawa, K; Shiba, K; Uno, I	1
Dal Col, V; Itami, K; Laurini, E; Meyer, C; Pricl, S; Schepmann, D; Wünsch, B; Yamaguchi, J; Yanagisawa, S	1
Itami, K; Meyer, C; Neue, B; Schepmann, D; Wünsch, B; Würthwein, EU; Yamaguchi, J; Yanagisawa, S	1
Amanlou, M; Arjmand, M; Daha, FJ; Ghandi, M; Hasani Bozcheloie, A; Sadeghzadeh, M; Sheibani, S	1
Harel, D; Schepmann, D; Wünsch, B	1
Bednarski, PJ; Brune, S; Dal Col, V; Korpis, K; Laurini, E; Pricl, S; Schepmann, D; Weber, F; Wünsch, B	1
Chen, Y; Lan, Y; Liu, BF; Liu, S; Liu, X; Qiu, Y; Xu, X; Zhang, G	1
Miyata, K; Möller, G; Schepmann, D; Wünsch, B	1
Harel, D; Laurini, E; Marson, D; Pricl, S; Schepmann, D; Schmidt, TJ; Wünsch, B	1
Bonifazi, A; Gawaskar, S; Schepmann, D; Wünsch, B	1
Cacciatore, I; Cataldi, A; Di Giacomo, V; Di Stefano, A; Fiorito, J; Marinelli, L; Marrazzo, A; Pacella, S; Parenti, C; Rescifina, A; Sozio, P; Turkez, H	1
Bonifazi, A; Gawaskar, S; Robaa, D; Schepmann, D; Sippl, W; Wünsch, B	1
Dey, S; Schepmann, D; Wünsch, B	2
Lütnant, I; Schepmann, D; Wünsch, B	1
Alirezapour, B; Ghandi, M; Sadeghzadeh, M; Sherafat, F	1
Bednarski, PJ; Börgel, F; Brune, S; Fermeglia, M; Korpis, K; Lange, C; Laurini, E; Pricl, S; Schepmann, D; Weber, F; Wünsch, B	1
Fermeglia, M; Laurini, E; Mamolo, MG; Pricl, S; Romano, M; Schepmann, D; Vio, L; Wünsch, B; Zampieri, D	1
Knappmann, I; Schepmann, D; Wünsch, B	1
Dey, S; Frehland, B; Lehmkuhl, K; Schepmann, D; Schreiber, JA; Seebohm, G; Strutz-Seebohm, N; Temme, L; Wünsch, B	1
Bracher, F; Fanter, L; Müller, C; Schepmann, D; Wünsch, B	1
Rath, S; Schepmann, D; Wünsch, B	1
Kitamura, M; Schepmann, D; Shuto, Y; Temme, L; Thum, S; Wünsch, B	1
Mamolo, MG; Menegazzi, R; Romano, M; Zampieri, D	1
Iyamu, ID; Lv, W; Malik, N; Mishra, RK; Schiltz, GE	1
Calabretti, A; Collina, S; Fortuna, S; Mamolo, MG; Menegazzi, R; Romano, M; Schepmann, D; Wünsch, B; Zampieri, D; Zanon, D	1
Baumeister, S; Schepmann, D; Wünsch, B	1
Calabretti, A; Fortuna, S; Mamolo, MG; Menegazzi, R; Romano, M; Schepmann, D; Wünsch, B; Zampieri, D	1
Börgel, F; Catapano, CV; Civenni, G; Friedland, K; Holtschulte, C; Humpf, HU; Kopp, N; Laurini, E; Lehmkuhl, K; Pricl, S; Schepmann, D; Wünsch, B	1
Almansa, C; Álvarez, I; Caamaño, AM; Cendán, CM; de la Puente, B; Díaz, JL; Enjo, J; García, M; Lorente, A; Maldonado, R; Martín, M; Montero, A; Port, A; Sicre, C; Torrens, A; Vela, JM; Vidal-Torres, A; Yeste, S	1
Bechthold, E; Daniliuc, C; Ritter, N; Schepmann, D; Schreiber, JA; Seebohm, G; Wünsch, B	1
Amata, E; Dichiara, M; Fortuna, S; Mamolo, MG; Marrazzo, A; Pasquinucci, L; Romano, M; Turnaturi, R; Zampieri, D	1
Bickford, PC; Kim, M	1
Elliot, M; Jansen, KL; Leslie, RA	1
DeHaven-Hudkins, DL; Fleissner, LC	1
Hudzik, TJ	1
Chavkin, C; Connor, MA	2
Blier, P; de Montigny, C; Debonnel, G; Monnet, FP	1
Codd, EE; Shank, RP	1
Hitosugi, H; Iwamoto, Y; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M	1
de Montigny, C; Debonnel, G; Fournier, A; Monnet, FP	1
Ross, SB	1
Musacchio, JM; Zhou, GZ	1
Itzhak, Y; Stein, I	1
Karbon, EW; Naper, K; Pontecorvo, MJ	1
Balestra, B; Candura, SM; Coccini, T; Costa, LG; Iapadre, N; Manzo, L; Tonini, M	1
Brent, PJ	1
Lipton, P; Lobner, D	1
Dragunow, M; Faull, RL; Jansen, K; Robertson, GS; Robertson, HA	1
Connick, JH; Fox, PK; France, L; Hanlon, GM; Nicholson, CD	1
Brown, JE; Middlemiss, DN; Reynolds, GP	1
Kesingland, AC; Singh, L; Tricklebank, MD; Wong, EH	1
De Montigny, C; Debonnel, G; Junien, JL; Monnet, FP	1
Bowen, WD; Hellewell, SB	1
Defaux, JP; Junien, JL; Pascaud, X; Rozé, C	1
Holtzman, SG	1
Chavkin, C; Neumaier, JF	1
Bobker, DH; Shen, KZ; Surprenant, A; Williams, JT	1
McLean, S; Weber, E	1
Battaglia, G; De Souza, EB; Jaffe, JH; Kulsakdinun, C; Wolfe, SA	1
Bastianetto, S; Perrault, G; Sanger, DJ	1
Brent, PJ; Dunkley, PR; Haynes, H; Jarvie, PE; Mudge, L; Sim, AT	1
Larson, AA; Sun, X	1
Appleyard, SM; Chavkin, C; Connor, M; Patterson, TA	1
DeCoster, MA; Klette, KL; Knight, ES; Tortella, FC	1
Baulieu, EE; Mahé, V; Monnet, FP; Robel, P	1
Shibata, S; Watanabe, S; Yamamoto, Y	1
Bailey, MA; Karbon, EW	1
Kest, B; Liebeskind, J; Mogil, JS; Pechnick, RN; Sternberg, WF	1
Barg, J; Eilam, Y; Ela, C; Hasin, Y; Vogel, Z	1
Hara, H; Harada, Y; Sukamoto, T	2
Nishikawa, T; Shirayama, Y; Takahashi, K	1
Bergeron, R; de Montigny, C; Debonnel, G; Gronier, B; Monnet, FP	1
De Costa, BR; Hudzik, TJ; McMillan, DE	1
Basile, AS; DeCosta, B; Paul, IA	1
Hara, H; Harada, Y; Sukamoto, T; Tanaka, K	1
Barfknecht, CF; Cheng, B; Ignace, CC; Iwai, Y; Newton, RE; Schoenwald, RD; Shirolkar, S; Vidvauns, S; Xia, E	1
Enomoto, R; Ogita, K; Yoneda, Y	1
Franklin, PH; Murray, TF; Roth, JE	1
Barfknecht, CF; Newton, RE; Schoenwald, RD; Xia, E	1
Bergeron, R; de Montigny, C; Debonnel, G	2
Brum, JM; Estafanous, FG; Murray, PA; Schubert, A; Tsuchida, H	1
Barfknecht, CF; Schoenwald, RD; Shirolkar, S; Xia, E	1
Kobayashi, T; Matsuno, K; Mita, S	1
Barrett, TW; Chang, S; Ha, BK; Liu, Y; Saini, P; Whitlock, BB; Wolfe, SA	1
Bowen, WD; Torrence-Campbell, C	1
Hornfeldt, CS; Kitto, KF; Larson, AA	1
Bowen, WD; de Costa, BR; Monnet, FP	1
Baine, Y; Daubert, JD; DeHaven-Hudkins, DL; Sawutz, DG; Tiberio, L	1
Ha, BK; Saini, P; Whitlock, BB; Wolfe, SA	1
Akiyama, K; Kuroda, S; Okumura, K; Ujike, H	1
Earley, B; Faherty, CJ; Leonard, BE	1
Fang, H; Helmeste, DM; Li, M; Tang, SW	1
Fei, YJ; Ganapathy, V; Huang, W; Leibach, FH; Li, HW; Seth, P	1
de Costa, BR; Matsumoto, RR; Tran, TT	1
Christie, MJ; Ingram, SL; Kassiou, M; Nguyen, VH	1
Hayashi, T; Kagaya, A; Nishida, A; Shimizu, M; Su, TP; Yamawaki, S	1
Maurice, T; Nabeshima, T; Noda, Y; Phan, VL; Privat, A; Yamada, K	1
Kamei, J	1
Donald, A; Kassiou, M; Mardon, K	1
Booze, RM; Mactutus, CF; Wallace, DR	1
John, C; Leyton, J; Moody, TW	1
Bräutigam, M; Gudermann, T; Habenicht, UF; Schaefer, M	1
Hillefors, M; von Euler, G	1
Hide, I; Ichimoto, H; Inoue, A; Nakata, Y; Shoji, H; Sugita, S	1
Higuchi, H; Sato, K; Shimizu, T; Takahashi, H; Yoshida, K	1
Cuevas, J; Zhang, H	1
Cagnotto, A; De Deurwaerdère, P; Marrazzo, A; Mennini, T; Moison, D; Prezzavento, O; Ronsisvalle, G; Spampinato, U	1
Abate, C; Berardi, F; Colabufo, NA; Contino, M; Niso, M; Perrone, R; Tortorella, V	1
Allmon, RL; Gustafson, JL; Lever, JR; Lever, SZ; Xu, R	1

Reviews

1 review(s) available for 1,3-ditolylguanidine and haloperidol

Article	Year
[Possible role of sigma-receptors in the regulation of cough reflex, gastrointestinal and retinal function]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1999, Volume: 114, Issue:1 Topics: Animals; Anti-Ulcer Agents; Antitussive Agents; Carbazoles; Guanidines; Haloperidol; Humans; Ligands; Pentazocine; Phenazocine; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Retinal Diseases	1999

Other Studies

146 other study(ies) available for 1,3-ditolylguanidine and haloperidol

Article	Year
Synthesis and biological evaluation of conformationally restricted 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylenediam ines as sigma receptor ligands. 1. Pyrrolidine, piperidine, homopiperidine, and tetrahydroisoquinoline classes. Journal of medicinal chemistry, 1992, Nov-13, Volume: 35, Issue:23 Topics: Animals; Ethylenediamines; Guinea Pigs; Isoquinolines; Molecular Conformation; Piperidines; Pyrrolidines; Receptors, sigma; Stereoisomerism; Structure-Activity Relationship	1992
Radiosynthesis, cerebral distribution, and binding of [125I]-1-(p-iodophenyl)-3-(1-adamantyl)guanidine, a ligand for sigma binding sites. Journal of medicinal chemistry, 1992, Dec-11, Volume: 35, Issue:25 Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Guanidines; Guinea Pigs; Iodobenzenes; Male; Mice; Receptors, sigma; Tissue Distribution	1992
Binding of substituted and conformationally restricted derivatives of N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane at sigma-receptors. Journal of medicinal chemistry, 1991, Volume: 34, Issue:6 Topics: Animals; Brain; Guinea Pigs; Microsomes; Phencyclidine; Propylamines; Radioligand Assay; Receptors, Opioid; Receptors, sigma; Substrate Specificity	1991
Radiosynthesis of sigma receptor ligands for positron emission tomography: 11C- and 18F-labeled guanidines. Journal of medicinal chemistry, 1991, Volume: 34, Issue:6 Topics: Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Fluorine Radioisotopes; Guanidines; Guinea Pigs; Magnetic Resonance Spectroscopy; Receptors, Opioid; Receptors, sigma; Tomography, Emission-Computed	1991
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. Journal of medicinal chemistry, 1995, May-26, Volume: 38, Issue:11 Topics: Animals; Binding Sites; Indoles; Ligands; Male; Piperidines; Rats; Rats, Wistar; Receptors, sigma; Sensitivity and Specificity; Structure-Activity Relationship	1995
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 2. Spiro-joined benzofuran, isobenzofuran, and benzopyran piperidines. Journal of medicinal chemistry, 1995, May-26, Volume: 38, Issue:11 Topics: Animals; Benzofurans; Benzopyrans; Binding Sites; Binding, Competitive; Brain; Male; Piperidines; Rats; Rats, Wistar; Receptors, sigma; Sensitivity and Specificity; Structure-Activity Relationship	1995
Synthesis and characterization of [125I]-N-(N-benzylpiperidin-4-yl)-4- iodobenzamide, a new sigma receptor radiopharmaceutical: high-affinity binding to MCF-7 breast tumor cells. Journal of medicinal chemistry, 1994, Jun-10, Volume: 37, Issue:12 Topics: Animals; Benzamides; Binding Sites; Breast Neoplasms; Guinea Pigs; Humans; Iodine Radioisotopes; Piperidines; Radionuclide Imaging; Receptors, sigma; Tumor Cells, Cultured	1994
Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds. Journal of medicinal chemistry, 1994, Jun-24, Volume: 37, Issue:13 Topics: Animals; Binding Sites; Brain; Cyclopentanes; Guinea Pigs; Molecular Weight; Piperazines; Piperidines; Radioligand Assay; Receptors, Dopamine; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma	1994
A new approach to the design of sigma-2-selective ligands: synthesis and evaluation of N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamine-related polyamines at sigma-1 and sigma-2 receptor subtypes. Journal of medicinal chemistry, 1994, Jan-21, Volume: 37, Issue:2 Topics: Animals; Binding Sites; Brain; Drug Design; Ethylamines; Guinea Pigs; In Vitro Techniques; Ligands; Liver; Male; Molecular Structure; Polyamines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, sigma	1994
Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamines at sigma receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds. Journal of medicinal chemistry, 1993, Aug-06, Volume: 36, Issue:16 Topics: Animals; Brain; Ethylamines; Guinea Pigs; Receptors, sigma; Structure-Activity Relationship	1993
New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives. Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1 Topics: Analgesics, Opioid; Animals; Binding Sites; Brain; Guinea Pigs; Magnetic Resonance Spectroscopy; Male; Pentazocine; Phencyclidine; Piperazines; Propylamines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Phencyclidine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Receptors, sigma; Serotonin; Serotonin Receptor Agonists; Structure-Activity Relationship; Tetrahydronaphthalenes	1996
Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1. Journal of medicinal chemistry, 2002, Jan-17, Volume: 45, Issue:2 Topics: Acetals; Animals; Binding, Competitive; Brain; Guinea Pigs; In Vitro Techniques; Ligands; Liver; Piperidines; Pyrones; Radioligand Assay; Rats; Receptors, sigma; Sigma-1 Receptor; Spiro Compounds; Structure-Activity Relationship	2002
Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. Journal of medicinal chemistry, 2005, Jan-13, Volume: 48, Issue:1 Topics: Animals; Binding Sites; Biochemistry; Cells, Cultured; Drug Evaluation, Preclinical; Guinea Pigs; Humans; Inhibitory Concentration 50; Ligands; Piperazines; Piperidines; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma; Serotonin 5-HT1 Receptor Agonists; Sigma-1 Receptor; Structure-Activity Relationship	2005
Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. Journal of medicinal chemistry, 2005, Jul-28, Volume: 48, Issue:15 Topics: Animals; Carrier Proteins; Databases, Factual; Guinea Pigs; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Isomerism; Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Radioligand Assay; Receptors, sigma; Saccharomyces cerevisiae; Sigma-1 Receptor; Steroid Isomerases	2005
Novel sigma receptor ligands: synthesis and biological profile. Journal of medicinal chemistry, 2007, Mar-08, Volume: 50, Issue:5 Topics: Animals; Astrocytes; Brain; Caspase 3; Cells, Cultured; Cyclopropanes; DNA Fragmentation; GTP-Binding Proteins; Guinea Pigs; In Vitro Techniques; Ligands; Piperidines; Protein Glutamine gamma Glutamyltransferase 2; Radioligand Assay; Rats; Rats, Wistar; Receptors, sigma; Stereoisomerism; Structure-Activity Relationship; Transglutaminases	2007
Synthesis of bridged piperazines with sigma receptor affinity. European journal of medicinal chemistry, 2007, Volume: 42, Issue:10 Topics: Cross-Linking Reagents; Molecular Structure; Piperazine; Piperazines; Receptors, sigma	2007
Tritium radiolabelling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization. Bioorganic & medicinal chemistry letters, 2008, Mar-15, Volume: 18, Issue:6 Topics: Animals; Binding Sites; Binding, Competitive; Cell Membrane; Liver; Molecular Structure; Piperazines; Radioligand Assay; Rats; Receptors, sigma; RNA, Messenger; Tritium	2008
Synthesis and structure-affinity relationships of novel spirocyclic sigma receptor ligands with furopyrazole structure. Bioorganic & medicinal chemistry, 2008, Mar-15, Volume: 16, Issue:6 Topics: Cyclization; Ligands; Pyrazoles; Radioligand Assay; Receptors, sigma; Spiro Compounds; Structure-Activity Relationship	2008
Substituted benzo[d]oxazol-2(3H)-one derivatives with preference for the sigma1 binding site. European journal of medicinal chemistry, 2009, Volume: 44, Issue:1 Topics: Animals; Benzoxazoles; Binding Sites; Binding, Competitive; Ligands; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship	2009
1,4-Diazepanes derived from (S)-serine--homopiperazines with improved sigma(1) (sigma) receptor affinity and selectivity. European journal of medicinal chemistry, 2009, Volume: 44, Issue:2 Topics: Azepines; Piperazine; Piperazines; Protein Binding; Receptors, sigma; Structure-Activity Relationship	2009
Thiophene bioisosteres of spirocyclic sigma receptor ligands. 1. N-substituted spiro[piperidine-4,4'-thieno[3,2-c]pyrans]. Journal of medicinal chemistry, 2008, Oct-23, Volume: 51, Issue:20 Topics: Alkylation; Animals; Cyclization; Ligands; Mice; Models, Molecular; Molecular Structure; Oxidation-Reduction; Pain; Piperidines; Protein Binding; Pyrans; Rats; Receptors, sigma; Spiro Compounds; Structure-Activity Relationship; Thiophenes	2008
Relationships between the structure of 6-allyl-6,8-diazabicyclo[3.2.2]nonane derivatives and their sigma receptor affinity and cytotoxic activity. Bioorganic & medicinal chemistry, 2009, Jan-15, Volume: 17, Issue:2 Topics: Alkanes; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclization; Humans; Piperazines; Protein Binding; Receptors, sigma; Small Cell Lung Carcinoma; Stereoisomerism; Structure-Activity Relationship	2009
Relationships between the structure of 6-substituted 6,8-diazabicyclo[3.2.2]nonan-2-ones and their sigma receptor affinity and cytotoxic activity. Bioorganic & medicinal chemistry, 2009, Feb-15, Volume: 17, Issue:4 Topics: Alkanes; Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Growth Processes; Cell Line, Tumor; Drug Screening Assays, Antitumor; Guinea Pigs; Humans; Ketones; Protein Binding; Rats; Receptors, sigma; Stereoisomerism; Structure-Activity Relationship	2009
Dancing of the second aromatic residue around the 6,8-diazabicyclo[3.2.2]nonane framework: influence on sigma receptor affinity and cytotoxicity. Journal of medicinal chemistry, 2009, Apr-09, Volume: 52, Issue:7 Topics: Animals; Antineoplastic Agents; Azabicyclo Compounds; Brain; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Guinea Pigs; Humans; In Vitro Techniques; Liver; Models, Molecular; Molecular Conformation; Radioligand Assay; Rats; Receptors, sigma; Stereoisomerism	2009
Synthesis of spirocyclic sigma1 receptor ligands as potential PET radiotracers, structure-affinity relationships and in vitro metabolic stability. Bioorganic & medicinal chemistry, 2009, May-15, Volume: 17, Issue:10 Topics: Animals; Cytochrome P-450 Enzyme System; Drug Stability; Guinea Pigs; Humans; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Receptors, sigma; Sigma-1 Receptor; Spiro Compounds; Structure-Activity Relationship	2009
Synthesis, biological evaluation, and three-dimensional in silico pharmacophore model for sigma(1) receptor ligands based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives. Journal of medicinal chemistry, 2009, Sep-10, Volume: 52, Issue:17 Topics: Animals; Benzene; Computational Biology; Ligands; Models, Molecular; Molecular Conformation; Oxazoles; Rats; Receptors, sigma; Sigma-1 Receptor	2009
Synthesis of sigma receptor ligands with unsymmetrical spiro connection of the piperidine moiety. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Animals; Guinea Pigs; Molecular Structure; Piperidines; Protein Binding; Rats; Receptors, sigma; Spiro Compounds; Structure-Activity Relationship	2009
Evaluation of spirocyclic 3-(3-fluoropropyl)-2-benzofurans as sigma1 receptor ligands for neuroimaging with positron emission tomography. Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19 Topics: Animals; Benzofurans; Biotransformation; Brain; Female; Fluorine Radioisotopes; Ligands; Mice; Microsomes, Liver; Neurons; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Rats; Receptors, sigma; Sigma-1 Receptor	2009
Conformationally constrained kappa receptor agonists: stereoselective synthesis and pharmacological evaluation of 6,8-diazabicyclo[3.2.2]nonane derivatives. Journal of medicinal chemistry, 2010, May-27, Volume: 53, Issue:10 Topics: Animals; Azabicyclo Compounds; Cell Line; Guinea Pigs; Humans; In Vitro Techniques; Molecular Conformation; Radioligand Assay; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship	2010
Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. Bioorganic & medicinal chemistry, 2010, Nov-15, Volume: 18, Issue:22 Topics: Analgesics; Animals; Benzazepines; Humans; Mice; Microsomes, Liver; Neuralgia; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship	2010
Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties. Journal of medicinal chemistry, 2011, May-26, Volume: 54, Issue:10 Topics: Animals; Cell Line, Tumor; Chemistry, Pharmaceutical; Cyclopropanes; Drug Design; Humans; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Muscle Contraction; Piperidines; Protein Binding; Receptors, Opioid, delta; Time Factors	2011
Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with high σ₁ receptor affinity. Journal of medicinal chemistry, 2011, Oct-13, Volume: 54, Issue:19 Topics: Analgesics; Animals; Brain; Guinea Pigs; Hyperalgesia; In Vitro Techniques; Liver; Mice; Pyrans; Pyrazoles; Radioligand Assay; Rats; Receptors, Opioid, delta; Spiro Compounds; Structure-Activity Relationship; Touch	2011
Thiophene bioisosteres of spirocyclic σ receptor ligands: relationships between substitution pattern and σ receptor affinity. Journal of medicinal chemistry, 2012, Jun-14, Volume: 55, Issue:11 Topics: Animals; Brain; Guinea Pigs; Ligands; Liver; Models, Molecular; Piperidines; Pyrans; Radioligand Assay; Rats; Receptors, sigma; Spiro Compounds; Structure-Activity Relationship; Thiophenes	2012
Microwave assisted synthesis of spirocyclic pyrrolidines -σ1 receptor ligands with modified benzene-N-distance. European journal of medicinal chemistry, 2012, Volume: 53 Topics: Animals; Benzene; Chemistry Techniques, Synthetic; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Humans; Ligands; Microwaves; Nitrogen; Pyrrolidines; Receptors, sigma; Spiro Compounds; Substrate Specificity	2012
Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT). Bioorganic & medicinal chemistry, 2012, Aug-15, Volume: 20, Issue:16 Topics: Animals; Male; Molecular Structure; Piperidines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, sigma; Vesicular Acetylcholine Transport Proteins	2012
Pd-catalyzed direct C-H bond functionalization of spirocyclic σ1 ligands: generation of a pharmacophore model and analysis of the reverse binding mode by docking into a 3D homology model of the σ1 receptor. Journal of medicinal chemistry, 2012, Sep-27, Volume: 55, Issue:18 Topics: Catalysis; Drug Design; Hydrogen Bonding; Ligands; Molecular Docking Simulation; Palladium; Protein Binding; Receptors, sigma; Reproducibility of Results; Sequence Homology, Amino Acid; Sigma-1 Receptor; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship	2012
Improvement of σ1 receptor affinity by late-stage C-H-bond arylation of spirocyclic lactones. Bioorganic & medicinal chemistry, 2013, Apr-01, Volume: 21, Issue:7 Topics: Animals; Guinea Pigs; Hydrophobic and Hydrophilic Interactions; Lactones; Protein Binding; Rats; Receptors, sigma; Sigma-1 Receptor; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Thiophenes	2013
Synthesis and receptor binding studies of novel 4,4-disubstituted arylalkyl/arylalkylsulfonyl piperazine and piperidine-based derivatives as a new class of σ1 ligands. European journal of medicinal chemistry, 2013, Volume: 64 Topics: Animals; Binding Sites; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Guinea Pigs; Ligands; Male; Molecular Conformation; Piperazine; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Structure-Activity Relationship	2013
New combination of pharmacophoric elements of potent σ₁ ligands: design, synthesis and σ receptor affinity of aminoethyl substituted tetrahydrobenzothiophenes. European journal of medicinal chemistry, 2013, Volume: 69 Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Design; Guinea Pigs; Ligands; Liver; Molecular Structure; Rats; Receptors, sigma; Structure-Activity Relationship; Thiophenes	2013
Synthesis, pharmacological evaluation, and σ1 receptor interaction analysis of hydroxyethyl substituted piperazines. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Antineoplastic Agents; Apoptosis; Brain; Chromatography, Thin Layer; Guinea Pigs; Humans; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Neoplasms; Piperazines; Protein Binding; Receptors, sigma; Structure-Activity Relationship; Tumor Cells, Cultured	2014
Synthesis and biological evaluation of a novel sigma-1 receptor antagonist based on 3,4-dihydro-2(1H)-quinolinone scaffold as a potential analgesic. European journal of medicinal chemistry, 2014, May-22, Volume: 79 Topics: Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Formaldehyde; Guinea Pigs; Hydroquinones; Mice; Mice, Inbred Strains; Molecular Structure; Nociceptive Pain; Pain Measurement; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship	2014
Pyridine analogues of spirocyclic σ₁ receptor ligands. Bioorganic & medicinal chemistry, 2014, Aug-01, Volume: 22, Issue:15 Topics: Animals; Brain; Cyclization; Guinea Pigs; Ligands; Liver; Protein Binding; Protein Isoforms; Pyrans; Pyridines; Rats; Receptors, sigma; Spiro Compounds; Structure-Activity Relationship	2014
Identification, pharmacological evaluation and binding mode analysis of novel chromene and chromane based σ1 receptor ligands. European journal of medicinal chemistry, 2014, Aug-18, Volume: 83 Topics: Chromans; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Protein Binding; Protein Conformation; Receptors, sigma	2014
Synthesis, GluN2B affinity and selectivity of benzo[7]annulen-7-amines. Bioorganic & medicinal chemistry, 2014, Dec-01, Volume: 22, Issue:23 Topics: Benzocycloheptenes; Dose-Response Relationship, Drug; Humans; Molecular Structure; Piperazines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship	2014
Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells. European journal of medicinal chemistry, 2015, Jan-27, Volume: 90 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glioma; Haloperidol; Molecular Structure; Prodrugs; Rats; Structure-Activity Relationship; Tumor Cells, Cultured	2015
Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position. Bioorganic & medicinal chemistry letters, 2015, Dec-15, Volume: 25, Issue:24 Topics: Amines; Binding Sites; Molecular Docking Simulation; Phenols; Piperidines; Protein Binding; Protein Structure, Tertiary; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship	2015
Role of the phenolic OH moiety of GluN2B-selective NMDA antagonists with 3-benzazepine scaffold. Bioorganic & medicinal chemistry letters, 2016, Feb-01, Volume: 26, Issue:3 Topics: Benzazepines; Binding Sites; Humans; Kinetics; Molecular Docking Simulation; Phenols; Piperidines; Protein Structure, Tertiary; Receptors, N-Methyl-D-Aspartate; Tritium	2016
Benzimidazolone bioisosteres of potent GluN2B selective NMDA receptor antagonists. European journal of medicinal chemistry, 2016, Jun-30, Volume: 116 Topics: Benzimidazoles; Drug Design; Humans; Receptors, N-Methyl-D-Aspartate	2016
One-pot synthesis and sigma receptor binding studies of novel spirocyclic-2,6-diketopiperazine derivatives. Bioorganic & medicinal chemistry letters, 2016, 06-01, Volume: 26, Issue:11 Topics: Animals; Binding Sites; Diketopiperazines; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Molecular Structure; Rats; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship	2016
Rigidity versus Flexibility: Is This an Issue in σ1 Receptor Ligand Affinity and Activity? Journal of medicinal chemistry, 2016, 06-09, Volume: 59, Issue:11 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Guinea Pigs; Heterocyclic Compounds, 2-Ring; Humans; Ligands; Models, Molecular; Molecular Structure; Piperazines; Receptors, sigma; Structure-Activity Relationship; Thermodynamics	2016
Computer-assisted design, synthesis, binding and cytotoxicity assessments of new 1-(4-(aryl(methyl)amino)butyl)-heterocyclic sigma 1 ligands. European journal of medicinal chemistry, 2016, Oct-04, Volume: 121 Topics: Antineoplastic Agents; Cell Line, Tumor; Chemistry Techniques, Synthetic; Computer-Aided Design; Heterocyclic Compounds; Humans; Ligands; Molecular Docking Simulation; Protein Conformation; Receptors, sigma; Structure-Activity Relationship	2016
Oxa-Pictet-Spengler reaction as key step in the synthesis of novel σ receptor ligands with 2-benzopyran structure. Bioorganic & medicinal chemistry, 2016, 09-15, Volume: 24, Issue:18 Topics: Animals; Benzopyrans; Guinea Pigs; Ligands; Piperidines; Rats; Receptors, sigma; Spiro Compounds	2016
Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors. European journal of medicinal chemistry, 2017, Sep-29, Volume: 138 Topics: Benzazepines; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship	2017
Chiral-pool synthesis of 1,2,4-trisubstituted 1,4-diazepanes as novel σ Bioorganic & medicinal chemistry, 2017, 09-01, Volume: 25, Issue:17 Topics: Animals; Azepines; Cholesterol; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; Kinetics; Ligands; Male; Muscle Contraction; Protein Binding; Receptors, sigma; Stereoisomerism; Structure-Activity Relationship; Yeasts	2017
Replacement of benzylic hydroxy group by vinyl or hydroxymethyl moiety at the 3-benzazepine scaffold retaining GluN2B affinity. Bioorganic & medicinal chemistry, 2017, 10-15, Volume: 25, Issue:20 Topics: Benzazepines; Dose-Response Relationship, Drug; Humans; Molecular Structure; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship	2017
2-Methyltetrahydro-3-benzazepin-1-ols - The missing link in SAR of GluN2B selective NMDA receptor antagonists. Bioorganic & medicinal chemistry, 2018, 01-15, Volume: 26, Issue:2 Topics: Benzazepines; Dose-Response Relationship, Drug; Humans; Molecular Docking Simulation; Molecular Structure; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship	2018
Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain? MedChemComm, 2017, May-01, Volume: 8, Issue:5 Topics:	2017
New piperidine-based derivatives as sigma receptor ligands. Synthesis and pharmacological evaluation. Bioorganic & medicinal chemistry letters, 2018, 10-15, Volume: 28, Issue:19 Topics: Cell Line, Tumor; Humans; Ligands; Piperidines; Receptors, sigma	2018
Discovery of a novel class of potent and selective tetrahydroindazole-based sigma-1 receptor ligands. Bioorganic & medicinal chemistry, 2019, 05-01, Volume: 27, Issue:9 Topics: Animals; Binding Sites; Indazoles; Ligands; Mice; Microsomes, Liver; Molecular Docking Simulation; Protein Structure, Tertiary; Receptors, sigma; Sigma-1 Receptor; Solubility; Structure-Activity Relationship	2019
Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents. European journal of medicinal chemistry, 2019, Oct-15, Volume: 180 Topics: Antioxidants; Benzothiazoles; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Discovery; Humans; Hydrogen Peroxide; Ligands; Models, Molecular; Molecular Structure; Neuroprotective Agents; Oxadiazoles; Oxidative Stress; Quinolones; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Structure-Activity Relationship; Sulfonic Acids	2019
Thiophene bioisosteres of GluN2B selective NMDA receptor antagonists: Synthesis and pharmacological evaluation of [7]annuleno[b]thiophen-6-amines. Bioorganic & medicinal chemistry, 2020, 01-15, Volume: 28, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; Molecular Structure; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Thiophenes	2020
Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands. ACS medicinal chemistry letters, 2020, May-14, Volume: 11, Issue:5 Topics:	2020
Novel σ European journal of medicinal chemistry, 2021, Jan-15, Volume: 210 Topics: Amination; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclohexanes; Humans; Male; Mice; Prostatic Neoplasms; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship	2021
EST64454: a Highly Soluble σ Journal of medicinal chemistry, 2020, 12-10, Volume: 63, Issue:23 Topics: Analgesics; Animals; Caco-2 Cells; Humans; Mice; Molecular Structure; Pain; Piperazines; Pyrazoles; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship	2020
Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil. European journal of medicinal chemistry, 2022, Jul-05, Volume: 237 Topics: Ligands; Piperidines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tropanes	2022
Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands. Bioorganic & medicinal chemistry letters, 2022, 09-15, Volume: 72 Topics: Haloperidol; Ligands; Piperidines; Quinolines; Receptors, sigma; Structure-Activity Relationship	2022
Electrophysiological effects of phencyclidine and the sigma agonist ditolylguanidine in the cerebellum of the rat. Neuropharmacology, 1992, Volume: 31, Issue:1 Topics: Animals; Cerebellum; Electrophysiology; Guanidines; Haloperidol; Male; Norepinephrine; Oxidopamine; Phencyclidine; Purkinje Fibers; Rats; Rats, Inbred Strains; Synaptic Transmission	1992
sigma receptors in rat brain and testes show similar reductions in response to chronic haloperidol. European journal of pharmacology, 1992, Apr-22, Volume: 214, Issue:2-3 Topics: Animals; Brain; Guanidines; Haloperidol; Kinetics; Male; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Testis	1992
Competitive interactions at [3H]1,3-di(2-tolyl)guanidine (DTG)-defined sigma recognition sites in guinea pig brain. Life sciences, 1992, Volume: 50, Issue:9 Topics: Animals; Antipsychotic Agents; Binding, Competitive; Carbazoles; Dopamine Agents; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Kinetics; Male; Pentazocine; Piperidines; Radioligand Assay; Receptors, Opioid; Receptors, sigma	1992
Sigma ligand-induced emesis in the pigeon. Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:1 Topics: Animals; Apomorphine; Columbidae; Dextromethorphan; Dizocilpine Maleate; Dopamine Agents; Guanidines; Haloperidol; Male; Pentobarbital; Phenazocine; Piperidines; Propranolol; Psychotropic Drugs; Pyrimidines; Receptors, Opioid; Receptors, sigma; Vomiting	1992
Ionic zinc may function as an endogenous ligand for the haloperidol-sensitive sigma 2 receptor in rat brain. Molecular pharmacology, 1992, Volume: 42, Issue:3 Topics: Animals; Binding, Competitive; Brain; Cations, Divalent; Copper; Electric Stimulation; Guanidines; Haloperidol; Hippocampus; Hydrogen-Ion Concentration; Kinetics; Male; Membranes; Pentazocine; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sensitivity and Specificity; Tritium; Zinc	1992
Modulation by sigma ligands of N-methyl-D-aspartate-induced [3H]noradrenaline release in the rat hippocampus: G-protein dependency. Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 346, Issue:1 Topics: Animals; Calcium; Cinnamates; Cyclopropanes; Dose-Response Relationship, Drug; Ethylmaleimide; GTP-Binding Proteins; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Norepinephrine; Pertussis Toxin; Piperidines; Rats; Rats, Inbred Strains; Spiperone; Tritium; Virulence Factors, Bordetella	1992
1,3-Di(2-[5-3H]tolyl)guanidine labels more than one site in rat forebrain. European journal of pharmacology, 1992, Jul-07, Volume: 217, Issue:2-3 Topics: Animals; Binding Sites; Binding, Competitive; Carbamazepine; Guanidines; Haloperidol; Male; Pentazocine; Phenytoin; Piperidines; Prosencephalon; Rats; Rats, Wistar; Receptors, sigma; Stereoisomerism	1992
Involvement of haloperidol-sensitive sigma-sites in antitussive effects. European journal of pharmacology, 1992, Nov-24, Volume: 224, Issue:1 Topics: Animals; Antitussive Agents; Capsaicin; Cough; Dose-Response Relationship, Drug; Drug Interactions; Guanidines; Haloperidol; Injections, Intraperitoneal; Male; Phenazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stereoisomerism	1992
Neuropeptide Y potentiates the N-methyl-D-aspartate response in the CA3 dorsal hippocampus. II. Involvement of a subtype of sigma receptor. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:3 Topics: Animals; Cinnamates; Cyclopropanes; Drug Synergism; Guanidines; Haloperidol; Hippocampus; Male; N-Methylaspartate; Neuropeptide Y; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Receptors, sigma; Spiperone	1992
Heterogeneous binding of sigma radioligands in the rat brain and liver: possible relationship to subforms of cytochrome P-450. Pharmacology & toxicology, 1991, Volume: 68, Issue:4 Topics: Animals; Brain; Cytochrome P-450 Enzyme System; Guanidines; Haloperidol; Kinetics; Ligands; Liver; Male; Phenazocine; Piperazines; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Subcellular Fractions	1991
Computer-assisted modeling of multiple dextromethorphan and sigma binding sites in guinea pig brain. European journal of pharmacology, 1991, Apr-25, Volume: 206, Issue:4 Topics: Animals; Binding Sites; Binding, Competitive; Brain; Computer Simulation; Dextromethorphan; Guanidines; Guinea Pigs; Haloperidol; Kinetics; Male; Models, Biological; Piperidines; Receptors, Opioid; Receptors, sigma; Tritium	1991
Regulation of sigma receptors and responsiveness to guanine nucleotides following repeated exposure of rats to haloperidol: further evidence for multiple sigma binding sites. Brain research, 1991, Dec-06, Volume: 566, Issue:1-2 Topics: Adenosine Triphosphate; Animals; Brain; Cell Membrane; Down-Regulation; Guanidines; Guanine Nucleotides; Guanylyl Imidodiphosphate; Haloperidol; Kinetics; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Reference Values	1991
[3H]DTG and [3H](+)-3-PPP label pharmacologically distinct sigma binding sites in guinea pig brain membranes. European journal of pharmacology, 1991, Jan-25, Volume: 193, Issue:1 Topics: Animals; Binding, Competitive; Brain; Dextromethorphan; Dopamine Agents; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Kinetics; Membranes; Phenazocine; Phenytoin; Piperidines; Receptors, Opioid; Receptors, sigma	1991
Two subtypes of enteric non-opioid sigma receptors in guinea-pig cholinergic motor neurons. European journal of pharmacology, 1991, May-30, Volume: 198, Issue:1 Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Carbazoles; Dextromethorphan; Electric Stimulation; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Male; Motor Neurons; Myenteric Plexus; Parasympathetic Nervous System; Phenazocine; Pyrimidines; Receptors, Opioid; Receptors, sigma	1991
Focal stimulation of specific pathways in the rat hippocampus causes a reduction in radioligand binding to the haloperidol-sensitive sigma receptor. Experimental brain research, 1991, Volume: 85, Issue:3 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Electric Stimulation; Guanidines; Haloperidol; Hippocampus; Male; Piperidines; Quinoxalines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma	1991
Similar behavioural effects of sigma agonists and PCP-like non-competitive NMDA antagonists in guinea-pigs. Psychopharmacology, 1991, Volume: 105, Issue:3 Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzamides; Dizocilpine Maleate; Dopamine Agents; Dopamine Antagonists; Ergolines; Female; Guanidines; Guinea Pigs; Haloperidol; Ketamine; Male; Motor Activity; N-Methylaspartate; Pentazocine; Phenazocine; Phencyclidine; Quinpirole; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma; Remoxipride	1991
Sigma-ligands and non-competitive NMDA antagonists inhibit glutamate release during cerebral ischemia. Neuroscience letters, 1990, Sep-04, Volume: 117, Issue:1-2 Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cyclazocine; Dizocilpine Maleate; Glutamates; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Ketamine; Kynurenic Acid; Male; Models, Neurological; Phencyclidine; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma	1990
D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons. Neuroscience, 1990, Volume: 37, Issue:2 Topics: Animals; Benzamides; Benzazepines; Corpus Striatum; Dizocilpine Maleate; Dopamine Antagonists; Guanidines; Haloperidol; Male; N-Methylaspartate; Neurons; Oncogene Proteins v-fos; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma	1990
The lack of utility of the rat vas deferens as a functional bioassay for sigma ligands. European journal of pharmacology, 1991, Feb-07, Volume: 193, Issue:2 Topics: Animals; Binding Sites; Biological Assay; Electric Stimulation; Guanidines; Guinea Pigs; Haloperidol; Male; Muscle Contraction; Pentazocine; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Vas Deferens	1991
[3H]ditolylguanidine binding to human brain sigma sites is diminished after haloperidol treatment. European journal of pharmacology, 1991, Mar-05, Volume: 194, Issue:2-3 Topics: Binding Sites; Brain; Guanidines; Haloperidol; Humans; Schizophrenia; Tritium	1991
Evidence against an involvement of the haloperidol-sensitive sigma recognition site in the discriminative stimulus properties of (+)-N-allylnormetazocine ((+)-SKF 10,047). British journal of pharmacology, 1990, Volume: 99, Issue:1 Topics: Animals; Aspartic Acid; Binding, Competitive; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Guanidines; Haloperidol; Male; Mice; N-Methylaspartate; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures	1990
N-methyl-D-aspartate-induced neuronal activation is selectively modulated by sigma receptors. European journal of pharmacology, 1990, Apr-25, Volume: 179, Issue:3 Topics: Animals; Aspartic Acid; Guanidines; Haloperidol; In Vitro Techniques; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Spiperone	1990
A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain. Brain research, 1990, Sep-17, Volume: 527, Issue:2 Topics: Adrenal Gland Neoplasms; Affinity Labels; Animals; Benzomorphans; Binding, Competitive; Brain; Cell Differentiation; Cell Line; Cell Membrane; Guanidines; Guinea Pigs; Haloperidol; Kinetics; Nerve Growth Factors; Pentazocine; Pheochromocytoma; Rats; Receptors, Opioid; Receptors, sigma	1990
Effect of selective sigma ligands on duodenal alkaline secretion in the rat. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3 Topics: Animals; Atropine; Bicarbonates; Dose-Response Relationship, Drug; Duodenum; Guanidines; Haloperidol; Injections, Intravenous; Intestinal Mucosa; Intestinal Secretions; Male; Naloxone; Phenazocine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Yohimbine	1990
Opioid- and phencyclidine-like discriminative effects of ditolylguanidine, a selective sigma ligand. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:3 Topics: Animals; Benzomorphans; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Generalization, Psychological; Guanidines; Haloperidol; Levorphanol; Male; Naltrexone; Narcotics; Phencyclidine; Rats; Receptors, Opioid; Receptors, sigma; Stereoisomerism	1989
Calcium-dependent displacement of haloperidol-sensitive sigma receptor binding in rat hippocampal slices following tissue depolarization. Brain research, 1989, Oct-23, Volume: 500, Issue:1-2 Topics: Animals; Calcium; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Veratridine	1989
DTG and (+)-3-PPP inhibit a ligand-activated hyperpolarization in mammalian neurons. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 251, Issue:3 Topics: Animals; Brimonidine Tartrate; Dopamine Agents; Enkephalin, Methionine; Guanidines; Haloperidol; Male; Membrane Potentials; Neurons; Norepinephrine; Piperidines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Serotonin	1989
Autoradiographic visualization of haloperidol-sensitive sigma receptors in guinea-pig brain. Neuroscience, 1988, Volume: 25, Issue:1 Topics: Animals; Autoradiography; Brain Chemistry; Guanidines; Guinea Pigs; Haloperidol; Kinetics; Receptors, Opioid; Receptors, sigma; Stereoisomerism; Substrate Specificity	1988
Initial identification and characterization of sigma receptors on human peripheral blood leukocytes. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3 Topics: Animals; Guanidines; Haloperidol; Leukocytes; Lymphocyte Activation; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Schizophrenia	1988
Pharmacological evidence for the involvement of sigma sites in DTG-induced contralateral circling in rats. Neuropharmacology, 1995, Volume: 34, Issue:1 Topics: Animals; Anticonvulsants; Behavior, Animal; Carbazoles; Dose-Response Relationship, Drug; Guanidines; Haloperidol; Injections, Spinal; Male; Motor Activity; Phenazocine; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, sigma; Salicylamides	1995
Phosphorylation of synapsin I and dynamin in rat forebrain synaptosomes: modulation by sigma (sigma) ligands. Neuroscience letters, 1995, May-19, Volume: 191, Issue:1-2 Topics: Animals; Anticonvulsants; Dynamins; GTP Phosphohydrolases; Guanidines; Haloperidol; In Vitro Techniques; Microtubules; Pentazocine; Phenazocine; Phosphorylation; Prosencephalon; Rats; Receptors, sigma; Synapsins; Synaptosomes	1995
Regulation of sigma activity by the amino-terminus of substance P in the mouse spinal cord: involvement of phencyclidine (PCP) sites not linked to N-methyl-D-aspartate (NMDA) activity. Neuropharmacology, 1993, Volume: 32, Issue:9 Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Drug Synergism; Guanidines; Haloperidol; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Peptide Fragments; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Receptors, sigma; Spinal Cord; Substance P; Up-Regulation	1993
Oocytes from Xenopus laevis contain an intrinsic sigma 2-like binding site. Neuroscience letters, 1994, Oct-24, Volume: 180, Issue:2 Topics: Animals; Binding Sites; Binding, Competitive; Carbazoles; Dextromethorphan; Female; Guanidines; Haloperidol; Liver; Mazindol; Oocytes; Pentazocine; Phenazocine; Piperazines; Piperidines; Radioligand Assay; Rats; Receptors, sigma; Xenopus laevis; Zinc	1994
Sigma receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures. Brain research, 1995, Feb-06, Volume: 671, Issue:1 Topics: Animals; Calcium; Cells, Cultured; Cyclazocine; Cyclopentanes; Dextromethorphan; Glutamic Acid; Guanidines; Haloperidol; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Pentazocine; Phenazocine; Piperidines; Rats; Receptors, sigma	1995
Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus. Proceedings of the National Academy of Sciences of the United States of America, 1995, Apr-25, Volume: 92, Issue:9 Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Female; Guanidines; Haloperidol; Hippocampus; Kinetics; N-Methylaspartate; Norepinephrine; Ovariectomy; Pertussis Toxin; Piperazines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Stereotaxic Techniques; Virulence Factors, Bordetella	1995
A role of sigma receptors on hypoxia/hypoglycemia-induced decrease in CA1 presynaptic fiber spikes in rat hippocampal slices. Brain research, 1995, Jan-30, Volume: 670, Issue:2 Topics: Action Potentials; Animals; Anisoles; Guanidines; Haloperidol; Hippocampus; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Male; Nerve Fibers; Presynaptic Terminals; Propylamines; Rats; Rats, Wistar; Receptors, sigma	1995
Haloperidol treatment differentially regulates [3H]DTG and [3H](+)-3-PPP labeled sigma binding sites. European journal of pharmacology, 1993, Aug-24, Volume: 240, Issue:2-3 Topics: Animals; Antipsychotic Agents; Binding Sites; Brain; Dopamine Agents; Drug Administration Schedule; Guanidines; Guinea Pigs; Haloperidol; Male; Phenytoin; Piperidines; Receptors, sigma	1993
Haloperidol increases pain behavior following peripheral tissue injury. Proceedings of the Western Pharmacology Society, 1994, Volume: 37 Topics: Animals; Anticonvulsants; Behavior, Animal; Formaldehyde; Guanidines; Haloperidol; Male; Mice; Pain Measurement	1994
Sigma receptor ligands modulate contractility, Ca++ influx and beating rate in cultured cardiac myocytes. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:3 Topics: Animals; Calcium; Cells, Cultured; GTP-Binding Proteins; Guanidines; Haloperidol; Heart Rate; Myocardial Contraction; Pentazocine; Piperidines; Rats; Receptors, sigma; Sarcoplasmic Reticulum	1994
Characterization of specific (+)-[3H]N-allylnormetazocine and [3H]1,3-di(2-tolyl)guanidine binding sites in porcine gastric fundic mucosa. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:3 Topics: Animals; Binding Sites; Gastric Fundus; Gastric Mucosa; Guanidines; Haloperidol; Phenazocine; Receptors, sigma; Swine	1994
Differential effects of repeated dl-pentazocine treatment on sigma binding sites in discrete brain areas of the rat. Neuroscience letters, 1994, Jan-03, Volume: 165, Issue:1-2 Topics: Animals; Anticonvulsants; Brain Chemistry; Dextroamphetamine; Guanidines; Haloperidol; Kinetics; Male; Methamphetamine; Pentazocine; Rats; Rats, Wistar; Receptors, sigma; Stereoisomerism	1994
Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain. European journal of pharmacology, 1994, May-02, Volume: 256, Issue:3 Topics: Animals; Anti-Ulcer Agents; Anticonvulsants; Binding, Competitive; Brain; Guanidines; Guinea Pigs; Haloperidol; Male; Piperazines; Receptors, sigma; Second Messenger Systems	1994
The effects of sigma ligands and of neuropeptide Y on N-methyl-D-aspartate-induced neuronal activation of CA3 dorsal hippocampus neurones are differentially affected by pertussin toxin. British journal of pharmacology, 1994, Volume: 112, Issue:2 Topics: Animals; Anticonvulsants; Cinnamates; Cyclopropanes; Drug Synergism; GTP-Binding Proteins; Guanidines; Haloperidol; Hippocampus; Ligands; Male; N-Methylaspartate; Neurons; Neuropeptide Y; Pentazocine; Pertussis Toxin; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, sigma; Virulence Factors, Bordetella	1994
Sigma receptor-mediated emetic response in pigeons: agonists, antagonists and modifiers. European journal of pharmacology, 1993, May-19, Volume: 236, Issue:2 Topics: Animals; Anti-Anxiety Agents; Antiemetics; Binding Sites; Columbidae; Drug Interactions; Emetics; Guanidines; Haloperidol; Male; Pyrimidines; Receptors, sigma; Vomiting	1993
Multiple [3H]DTG binding sites in guinea pig cerebellum: evidence for the presence of non-specific binding. European journal of pharmacology, 1994, Feb-03, Volume: 252, Issue:2 Topics: Animals; Anticonvulsants; Binding, Competitive; Cerebellum; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Levallorphan; Liver; Male; Membranes; Models, Biological; Pentazocine; Receptors, sigma	1994
Sigma receptor-mediated effects of a new antiulcer agent, KB-5492, on experimental gastric mucosal lesions and gastric alkaline secretion in rats. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:2 Topics: Animals; Anti-Ulcer Agents; Autoradiography; Carbazoles; Ethanol; Gastric Mucosa; Guanidines; Haloperidol; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stomach Ulcer; Stress, Physiological	1994
Lacrimal secretion stimulants: sigma receptors and drug implications. Journal of ocular pharmacology, 1993,Fall, Volume: 9, Issue:3 Topics: Animals; Bromhexine; Dose-Response Relationship, Drug; Eye Proteins; Female; Guanidines; Haloperidol; In Vitro Techniques; Lacrimal Apparatus; Male; Rabbits; Receptors, sigma; Secretory Rate; Spiperone; Tears	1993
Multiplicity of [3H]1,3-di-o-tolylguanidine binding sites with low affinity for haloperidol in rat brain. Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:10 Topics: Animals; Binding Sites; Brain; Guanidines; Haloperidol; Male; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, sigma	1993
The sigma receptor ligand 1,3-di(2-tolyl)guanidine is anticonvulsant in the rat prepiriform cortex. European journal of pharmacology, 1993, May-19, Volume: 236, Issue:2 Topics: Animals; Anticonvulsants; Bicuculline; Brain; Drug Interactions; Guanidines; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Receptors, sigma; Seizures	1993
The presence of sigma-receptors in the lacrimal gland. Journal of ocular pharmacology, 1993,Summer, Volume: 9, Issue:2 Topics: Animals; Binding, Competitive; Cell Membrane; Female; Guanidines; Haloperidol; Lacrimal Apparatus; Male; Rabbits; Radioligand Assay; Receptors, sigma; Spiperone	1993
Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, Feb-01, Volume: 16, Issue:3 Topics: Animals; Anisoles; Dehydroepiandrosterone; Drug Synergism; Female; Guanidines; Haloperidol; Hippocampus; Iontophoresis; Ligands; Male; N-Methylaspartate; Pertussis Toxin; Pregnenolone; Progesterone; Propylamines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Spiperone; Virulence Factors, Bordetella	1996
Sigma receptor activation does not mediate fentanyl-induced attenuation of muscarinic coronary contraction. Anesthesia and analgesia, 1996, Volume: 82, Issue:5 Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Coronary Vessels; Cyclazocine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fentanyl; Guanidines; Haloperidol; Muscarine; Muscarinic Agonists; Narcotic Antagonists; Narcotics; Pentazocine; Phencyclidine; Piperidines; Potassium Channel Blockers; Receptors, Dopamine; Receptors, sigma; Signal Transduction; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents	1996
The effects of sigma ligands on protein release from lacrimal acinar cells: a potential agonist/antagonist assay. Life sciences, 1995, Mar-03, Volume: 56, Issue:15 Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Eye Proteins; Guanidines; Haloperidol; In Vitro Techniques; Lacrimal Apparatus; Pentazocine; Phenethylamines; Pyrimidines; Rabbits; Receptors, sigma	1995
Involvement of sigma-receptors in the increase in contraction of mouse vas deferens induced by exogenous ATP. The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:1 Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Anticonvulsants; Antipsychotic Agents; Carbazoles; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Guanidines; Haloperidol; Ligands; Male; Mice; Muscle Contraction; Muscle, Smooth; Pentazocine; Phenazocine; Piperidines; Receptors, sigma; Regression Analysis; Structure-Activity Relationship; Vas Deferens	1996
Initial characterization and autoradiographic localization of a novel sigma/opioid binding site in immune tissues. Journal of neuroimmunology, 1996, Volume: 67, Issue:2 Topics: Animals; Anticonvulsants; Autoradiography; Binding Sites; Binding, Competitive; Brain Chemistry; Cytochrome P-450 Enzyme System; Dopamine Agonists; Dopamine Antagonists; Female; Guanidines; Haloperidol; Hydrogen-Ion Concentration; Kinetics; Leukocytes; Monoamine Oxidase; Naltrexone; Narcotic Antagonists; Narcotics; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Spleen; Tritium	1996
Differential solubilization of rat liver sigma 1 and sigma 2 receptors: retention of sigma 2 sites in particulate fractions. European journal of pharmacology, 1996, May-23, Volume: 304, Issue:1-3 Topics: Animals; Binding, Competitive; Cell Fractionation; Cell Membrane; Cholic Acids; Detergents; Guanidines; Haloperidol; In Vitro Techniques; Liver; Male; Pentazocine; Phenazocine; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Solubility; Subcellular Fractions	1996
Evidence that the NH2-terminus of substance P modulates N-methyl-D-aspartate-induced activity by an action involving sigma receptors. European journal of pharmacology, 1996, Jun-13, Volume: 306, Issue:1-3 Topics: Analysis of Variance; Animals; Anticonvulsants; Antipsychotic Agents; Behavior, Animal; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Guanidines; Haloperidol; Male; Mice; N-Methylaspartate; Receptors, sigma; Substance P	1996
Differentiation of sigma ligand-activated receptor subtypes that modulate NMDA-evoked [3H]-noradrenaline release in rat hippocampal slices. British journal of pharmacology, 1996, Volume: 119, Issue:1 Topics: Animals; Anisoles; Anticonvulsants; Antipsychotic Agents; Cyclohexylamines; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Ligands; Male; N-Methylaspartate; Narcotics; Norepinephrine; Pentazocine; Propylamines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Tritium	1996
[3H]1,3-di(2-tolyl) guanidine binds to a sigma 2 receptor on Jurkat cell membranes, but sigma compounds fail to influence immunomodulatory events in human peripheral blood lymphocytes. Immunopharmacology, 1996, Volume: 35, Issue:1 Topics: Binding, Competitive; Cell Membrane; Guanidines; Haloperidol; Humans; Interleukin-2; Jurkat Cells; Lymphocyte Activation; Narcotics; Pentazocine; Protein Binding; Receptors, sigma; T-Lymphocytes	1996
Differential localization of three distinct binding sites for sigma receptor ligands in rat spleen. Journal of neuroimmunology, 1997, Volume: 72, Issue:1 Topics: Analgesics, Opioid; Animals; Anticonvulsants; Antipsychotic Agents; Autoradiography; Binding Sites; Dopamine Agonists; Dopamine Antagonists; Female; Guanidines; Haloperidol; Image Processing, Computer-Assisted; Ligands; Male; Naltrexone; Narcotic Antagonists; Pentazocine; Phenazocine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Spleen; Tritium	1997
BMY-14802 reversed the sigma receptor agonist-induced neck dystonia in rats. Journal of neural transmission (Vienna, Austria : 1996), 1996, Volume: 103, Issue:10 Topics: Animals; Antipsychotic Agents; Dibenzothiepins; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dystonia; Guanidines; Haloperidol; Male; Microinjections; Nerve Tissue Proteins; Perphenazine; Piperidines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, sigma; Red Nucleus; Sulpiride; Torticollis	1996
Behavioural effects of selective serotonin reuptake inhibitors following direct micro injection into the left red nucleus of the rat. Journal of psychopharmacology (Oxford, England), 1997, Volume: 11, Issue:1 Topics: 1-Naphthylamine; Animals; Behavior, Animal; Chlorpromazine; Citalopram; Fluoxetine; Fluvoxamine; Guanidines; Haloperidol; Male; Microinjections; Motor Activity; Paroxetine; Piperidines; Posture; Rats; Rats, Sprague-Dawley; Receptors, sigma; Red Nucleus; Selective Serotonin Reuptake Inhibitors; Sertraline	1997
Effect of short-term and long-term treatments with sigma ligands on the N-methyl-D-aspartate response in the CA3 region of the rat dorsal hippocampus. British journal of pharmacology, 1997, Volume: 120, Issue:7 Topics: Animals; Cinnamates; Cyclopropanes; Guanidines; Haloperidol; Hippocampus; Male; N-Methylaspartate; Pentazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma	1997
Multiple [3H]-nemonapride binding sites in calf brain. Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Benzamides; Binding, Competitive; Brain; Cattle; Cerebellum; Cerebral Cortex; Corpus Striatum; Dioxanes; Dopamine Agonists; Dopamine Antagonists; Guanidines; Haloperidol; In Vitro Techniques; Isotope Labeling; Narcotic Antagonists; Pentazocine; Piperidines; Propylamines; Pyrrolidines; Receptors, Dopamine D2; Receptors, sigma; Sulpiride; Tritium	1997
Cloning and functional characterization of a sigma receptor from rat brain. Journal of neurochemistry, 1998, Volume: 70, Issue:3 Topics: Amino Acid Sequence; Animals; Anticonvulsants; Antidepressive Agents; Base Sequence; Binding, Competitive; Brain Chemistry; Choriocarcinoma; Cloning, Molecular; Clorgyline; DNA, Complementary; Dopamine Antagonists; Gene Expression; Gene Library; Guanidines; Haloperidol; HeLa Cells; Humans; Kinetics; Liver; Molecular Sequence Data; Narcotics; Pentazocine; Phenytoin; Placenta; Rats; Receptors, sigma; RNA, Messenger; Steroids	1998
Microinjection of sigma ligands into cranial nerve nuclei produces vacuous chewing in rats. Psychopharmacology, 1998, Volume: 137, Issue:2 Topics: Animals; Antipsychotic Agents; Ethylenediamines; Facial Nerve; Guanidines; Haloperidol; Male; Mastication; Microinjections; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Trigeminal Nucleus, Spinal	1998
Sigma-binding site ligands inhibit K+ currents in rat locus coeruleus neurons in vitro. European journal of pharmacology, 1998, Nov-13, Volume: 361, Issue:1 Topics: Action Potentials; Animals; Anticonvulsants; Binding Sites; Binding, Competitive; Cell Membrane; Dextromethorphan; Dopamine Antagonists; Enkephalin, Methionine; Excitatory Amino Acid Antagonists; Guanidines; Haloperidol; In Vitro Techniques; Ligands; Locus Coeruleus; Male; Narcotics; Neurons; Pentazocine; Potassium Channels; Rats; Rats, Sprague-Dawley	1998
Neuroleptics with differential affinities at dopamine D2 receptors and sigma receptors affect differently the N-methyl-D-aspartate-induced increase in intracellular calcium concentration: involvement of protein kinase. Synapse (New York, N.Y.), 1999, Volume: 31, Issue:1 Topics: Animals; Antipsychotic Agents; Calcium; Cells, Cultured; Chlorpromazine; Clozapine; Dopamine Antagonists; Frontal Lobe; Guanidines; Haloperidol; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, sigma; Sulpiride	1999
The attenuation of learning impairments induced after exposure to CO or trimethyltin in mice by sigma (sigma) receptor ligands involves both sigma1 and sigma2 sites. British journal of pharmacology, 1999, Volume: 127, Issue:2 Topics: Amnesia; Animals; Anticonvulsants; Avoidance Learning; Carbon Monoxide; Ethylamines; Guanidines; Haloperidol; Learning Disabilities; Ligands; Male; Memory Disorders; Mice; Pyrrolidines; Receptors, sigma; Sigma-1 Receptor; Trimethyltin Compounds	1999
Effects of streptozotocin-induced diabetes on neuronal sigma receptors in the rat brain. Life sciences, 1999, Oct-29, Volume: 65, Issue:23 Topics: Analgesics, Opioid; Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental; Glycosuria; Guanidines; Haloperidol; Kinetics; Male; Pentazocine; Rats; Rats, Wistar; Receptors, sigma	1999
Sigma binding sites identified by [(3)H] DTG are elevated in aged Fischer-344 x Brown Norway (F1) rats. Synapse (New York, N.Y.), 2000, Mar-15, Volume: 35, Issue:4 Topics: Aging; Animals; Anticonvulsants; Binding Sites; Corpus Striatum; Guanidines; Haloperidol; Male; Raclopride; Rats; Rats, Inbred BN; Rats, Inbred F344; Receptors, Dopamine D2; Receptors, sigma; Tritium	2000
Sigma ligands inhibit the growth of small cell lung cancer cells. Life sciences, 2000, Apr-07, Volume: 66, Issue:20 Topics: Animals; Benzamides; Binding, Competitive; Carcinoma, Small Cell; Cell Division; Female; Guanidines; Haloperidol; Humans; Ligands; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Piperidines; Receptors, sigma; Tumor Cells, Cultured	2000
Steroidal sigma receptor ligands affect signaling pathways in human spermatozoa. Biology of reproduction, 2000, Volume: 63, Issue:1 Topics: Acrosome Reaction; Alprostadil; Animals; Calcium; Cell Line; Estrone; Exocytosis; Fibroblasts; Guanidines; Haloperidol; Humans; Ligands; Male; Mice; Phosphatidylinositols; Pregnatrienes; Progesterone; Receptors, Progesterone; Receptors, sigma; Signal Transduction; Spermatozoa; Steroids	2000
Pharmacology of [3H]R(+)-7-OH-DPAT binding in the rat caudate-putamen. Neurochemistry international, 2001, Volume: 38, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzopyrans; Binding, Competitive; Caudate Nucleus; Clozapine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Guanidines; Guanosine Triphosphate; Haloperidol; Heterotrimeric GTP-Binding Proteins; Indans; Kinetics; Magnesium; Male; Oxazines; Protein Binding; Putamen; Quinpirole; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Remoxipride; Sodium; Specific Pathogen-Free Organisms; Sulfones; Sulpiride; Tetrahydronaphthalenes	2001
Repeated haloperidol treatment decreases sigma(1) receptor binding but does not affect its mRNA levels in the guinea pig or rat brain. European journal of pharmacology, 2000, Aug-11, Volume: 401, Issue:3 Topics: Animals; Antipsychotic Agents; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Haloperidol; Male; Pentazocine; Radioligand Assay; Rats; Rats, Wistar; Receptors, sigma; RNA, Messenger; Tritium	2000
Biperiden hydrochlorate ameliorates dystonia of rats produced by microinjection of sigma ligands into the red nucleus. Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:3 Topics: Animals; Anti-Dyskinesia Agents; Anticonvulsants; Biperiden; Disease Models, Animal; Guanidines; Haloperidol; Male; Muscarinic Antagonists; Neuroleptic Malignant Syndrome; Rats; Rats, Wistar; Receptors, sigma; Red Nucleus; Torticollis	2000
Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons. Journal of neurophysiology, 2002, Volume: 87, Issue:6 Topics: Analgesics, Opioid; Animals; Anticonvulsants; Calcium; Calcium Channels; Cells, Cultured; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Ganglia, Parasympathetic; Gene Expression; Guanidines; Guanosine Diphosphate; Guanosine Triphosphate; Haloperidol; Ibogaine; Ion Channel Gating; Membrane Potentials; Microdialysis; Neurons; Pentazocine; Rats; Receptors, sigma; RNA, Messenger; Signal Transduction; Superior Cervical Ganglion; Thionucleotides	2002
Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo. Neuropharmacology, 2003, Volume: 45, Issue:7 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Cyclopropanes; Dopamine; Dopamine Antagonists; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Male; Microinjections; Neostriatum; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma	2003
Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines. Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 370, Issue:2 Topics: Animals; Anisoles; Antineoplastic Agents; Binding, Competitive; Brain; Cell Line, Tumor; Guanidines; Guinea Pigs; Haloperidol; Humans; In Vitro Techniques; Ligands; Liver; Membranes; Pentazocine; Piperazines; Propylamines; Pyridines; Radioligand Assay; Rats; Receptors, sigma; Sigma-1 Receptor	2004
Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse (New York, N.Y.), 2006, Volume: 59, Issue:6 Topics: Animals; Autoradiography; Binding, Competitive; Brain; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluorine Radioisotopes; Guanidines; Guinea Pigs; Haloperidol; Inhibitory Concentration 50; Ligands; Male; Narcotic Antagonists; Pentazocine; Piperazines; Protein Binding; Radioligand Assay; Radiopharmaceuticals; Receptors, sigma; Structure-Activity Relationship	2006