1,3-ditolylguanidine has been researched along with dizocilpine maleate in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.54) | 18.7374 |
| 1990's | 20 (76.92) | 18.2507 |
| 2000's | 3 (11.54) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hudzik, TJ | 1 |
| Brent, PJ | 1 |
| Lipton, P; Lobner, D | 2 |
| Dragunow, M; Faull, RL; Jansen, K; Robertson, GS; Robertson, HA | 1 |
| Boksa, P; Chaudieu, I; Mount, H; Quirion, R | 1 |
| Kim, HS; Lehmann, J; Martin, LL; Rao, TS; Wood, PL | 1 |
| Kesingland, AC; Singh, L; Tricklebank, MD; Wong, EH | 1 |
| Nielsen, M; Wong, EH | 1 |
| Denavit-Saubié, M; Foutz, AS | 1 |
| Contreras, ML; Contreras, PC; Lair, CC; O'Donohue, TL | 1 |
| Sonsalla, PK; Terleckyj, I | 1 |
| Fischer, JB; Kirk, CJ; Knapp, AG; McBurney, RN; Reddy, NL; Wolcott, TC | 1 |
| Larson, AA; Sun, X | 1 |
| Hasegawa, T; Hiramatsu, M; Itoh, J; Kameyama, T; Maurice, T; Nabeshima, T | 2 |
| Hashimoto, K; London, ED; Mantione, CR; Neumeyer, JL; Spada, MR | 1 |
| McCann, DJ; Su, TP; Weissman, AD | 1 |
| Burge, LJ; Scalzo, FM | 1 |
| Chiodo, LA; Freeman, AS; Zhang, J | 1 |
| Rückert, NG; Schmidt, WJ | 1 |
| Furukawa, H; Hasegawa, T; Kitaichi, K; Nabeshima, T; Noda, Y | 1 |
| Borowicz, KK; Czuczwar, SJ; Kleinrok, Z | 1 |
| Auerbach, EA; Duncan-Smith, MK; George, JR; Graves, WW; Turgeon, SM | 1 |
| Berardi, F; Colabufo, NA; Ferorelli, S; Leopoldo, M; Perrone, R; Tortorella, V | 1 |
| Aoki, K; Narita, M; Nomura, M; Suzuki, T; Yoshizawa, K | 1 |
26 other study(ies) available for 1,3-ditolylguanidine and dizocilpine maleate
| Article | Year |
|---|---|
Sigma ligand-induced emesis in the pigeon.
Topics: Animals; Apomorphine; Columbidae; Dextromethorphan; Dizocilpine Maleate; Dopamine Agents; Guanidines; Haloperidol; Male; Pentobarbital; Phenazocine; Piperidines; Propranolol; Psychotropic Drugs; Pyrimidines; Receptors, Opioid; Receptors, sigma; Vomiting | 1992 |
Similar behavioural effects of sigma agonists and PCP-like non-competitive NMDA antagonists in guinea-pigs.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzamides; Dizocilpine Maleate; Dopamine Agents; Dopamine Antagonists; Ergolines; Female; Guanidines; Guinea Pigs; Haloperidol; Ketamine; Male; Motor Activity; N-Methylaspartate; Pentazocine; Phenazocine; Phencyclidine; Quinpirole; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma; Remoxipride | 1991 |
Sigma-ligands and non-competitive NMDA antagonists inhibit glutamate release during cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cyclazocine; Dizocilpine Maleate; Glutamates; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Ketamine; Kynurenic Acid; Male; Models, Neurological; Phencyclidine; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma | 1990 |
D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons.
Topics: Animals; Benzamides; Benzazepines; Corpus Striatum; Dizocilpine Maleate; Dopamine Antagonists; Guanidines; Haloperidol; Male; N-Methylaspartate; Neurons; Oncogene Proteins v-fos; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma | 1990 |
Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Binding Sites; Cells, Cultured; Dioxolanes; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Guanidines; Mesencephalon; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Phencyclidine; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Sigma Factor; Tritium | 1990 |
Selective activation of dopaminergic pathways in the mesocortex by compounds that act at the phencyclidine (PCP) binding site: tentative evidence for PCP recognition sites not coupled to N-methyl-D-aspartate (NMDA) receptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Carbazoles; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Guanidines; Ligands; Male; Neural Pathways; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stereoisomerism | 1990 |
Evidence against an involvement of the haloperidol-sensitive sigma recognition site in the discriminative stimulus properties of (+)-N-allylnormetazocine ((+)-SKF 10,047).
Topics: Animals; Aspartic Acid; Binding, Competitive; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Guanidines; Haloperidol; Male; Mice; N-Methylaspartate; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures | 1990 |
The N-methyl-D-aspartate receptor channel complex and the sigma site have different target sizes.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Guanidines; In Vitro Techniques; Ion Channels; Membranes; Molecular Weight; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Differentiation of phencyclidine and sigma receptor types affecting the central inspiratory termination mechanism in cat.
Topics: Animals; Brain Stem; Cats; Decerebrate State; Dextrorphan; Dibenzocycloheptenes; Dizocilpine Maleate; Guanidines; Phencyclidine; Phrenic Nerve; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Respiration | 1989 |
Biochemical and behavioral effects of sigma and PCP ligands.
Topics: Animals; Anticonvulsants; Binding, Competitive; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Guanidines; Kinetics; Ligands; Male; Membranes; Narcotics; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Stereotyped Behavior | 1988 |
The sigma receptor ligand (+/-)-BMY 14802 prevents methamphetamine-induced dopaminergic neurotoxicity via interactions at dopamine receptors.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Brain Diseases; Butaclamol; Carbazoles; Dizocilpine Maleate; Dopamine; Dopamine Agents; Drug Interactions; Drug Synergism; Guanidines; Ligands; Male; Methamphetamine; Mice; MPTP Poisoning; Neostriatum; Piperidines; Psychotropic Drugs; Pyrimidines; Receptors, Dopamine; Receptors, sigma; Stereoisomerism; Tyrosine 3-Monooxygenase | 1994 |
In vitro neuroprotection by substituted guanidines with varying affinities for the N-methyl-D-aspartate receptor ionophore and for sigma sites.
Topics: Animals; Cells, Cultured; Dizocilpine Maleate; Glutamic Acid; Guanidines; Ion Channels; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Structure-Activity Relationship | 1994 |
Regulation of sigma activity by the amino-terminus of substance P in the mouse spinal cord: involvement of phencyclidine (PCP) sites not linked to N-methyl-D-aspartate (NMDA) activity.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Drug Synergism; Guanidines; Haloperidol; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Peptide Fragments; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Receptors, sigma; Spinal Cord; Substance P; Up-Regulation | 1993 |
Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Guanidines; Male; Memory; Mice; Mice, Inbred Strains; Motor Activity; Pentazocine; Phenazocine; Pyrimidines; Receptors, sigma; Space Perception | 1994 |
Further characterization of [3H]ifenprodil binding in rat brain.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brain; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Guanidines; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Piperazines; Piperidines; Rats; Rats, Inbred F344; Receptors, sigma | 1994 |
Sigma-1 and sigma-2 sites in rat brain: comparison of regional, ontogenetic, and subcellular patterns.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Dizocilpine Maleate; Female; Guanidines; In Vitro Techniques; Male; Membranes; Phenazocine; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, sigma; Subcellular Fractions | 1994 |
Behavioral evidence for a modulating role of sigma ligands in memory processes. I. Attenuation of dizocilpine (MK-801)-induced amnesia.
Topics: Amnesia; Animals; Behavior, Animal; Dizocilpine Maleate; Guanidines; Ligands; Male; Memory; Mice; Receptors, sigma | 1994 |
The role of NMDA and sigma systems in the behavioral effects of phencyclidine in preweanling rats.
Topics: Animals; Animals, Suckling; Anticonvulsants; Ataxia; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Guanidines; Male; Motor Activity; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1994 |
Intracellular calcium levels and calcium fluxes in the CA1 region of the rat hippocampal slice during in vitro ischemia: relationship to electrophysiological cell damage.
Topics: Amiloride; Animals; Calcium; Dizocilpine Maleate; Ethers, Cyclic; Guanidines; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Kinetics; Male; Microscopy, Electron; Okadaic Acid; Pyramidal Tracts; Quinoxalines; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Effects of phencyclidine, MK-801 and 1,3-di(2-tolyl)guanidine on non-dopaminergic midbrain neurons.
Topics: Action Potentials; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Guanidines; Injections, Intravenous; Male; Mesencephalon; Neurons; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1993 |
The sigma receptor ligand 1,3-di-(2-tolyl)guanidine in animal models of schizophrenia.
Topics: Amphetamine; Animals; Behavior, Animal; Binding Sites; Dizocilpine Maleate; Guanidines; Male; Models, Biological; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, sigma; Schizophrenia | 1993 |
In vivo functional interaction between phencyclidine binding sites and sigma receptors to produce head-weaving behavior in rats.
Topics: Animals; Anisoles; Behavior, Animal; Binding Sites; Dizocilpine Maleate; Guanidines; Male; Phenazocine; Piperidines; Propylamines; Pyrimidines; Rats; Rats, Wistar; Receptors, Phencyclidine; Receptors, sigma | 1996 |
Influence of 3-PPP, a sigma receptor ligand, on the anticonvulsive action of conventional antiepileptic drugs.
Topics: Animals; Anticonvulsants; Avoidance Learning; Dizocilpine Maleate; Female; Guanidines; Mice; Phenobarbital; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Valproic Acid | 1999 |
The delayed effects of DTG and MK-801 on latent inhibition in a conditioned taste-aversion paradigm.
Topics: Animals; Conditioning, Psychological; Dizocilpine Maleate; Drug Interactions; Eating; Excitatory Amino Acid Antagonists; Food Preferences; Guanidines; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sucrose; Taste | 2000 |
A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites.
Topics: Animals; Binding Sites; Brain; Calcium Channels, L-Type; Carrier Proteins; Dizocilpine Maleate; Guanidines; Guinea Pigs; In Vitro Techniques; Inhibitory Concentration 50; Ligands; Liver; Pentazocine; Piperidines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Structure-Activity Relationship | 2001 |
Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine.
Topics: Animals; Dextromethorphan; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Guanidines; Ketamine; Ligands; Male; Phencyclidine; Piperazines; Piperidines; Protein Subunits; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 2001 |